AI ASSISTANT
Ask DrugCentral
Explore drug properties, targets, and indications with answers grounded in DrugCentral.
Powered by DrugCentral + retrieval-augmented AIYour question
Ask in your own words. Each question is answered independently.
Explore sample questions
Select a question to fill the editor, then ask it or make it your own.
DrugCentral answer
Your answer will appear here. Open linked drug cards in a new tab to explore the source details.
About Ask DrugCentral
Ask DrugCentral helps you explore drug properties, biological targets, and indications using natural language. Sample questions offer starting points, and linked drug cards let you check the underlying records.
General architecture
- Ask a questionThe browser sends your question to the same-origin Django chat API.
- Retrieve and generateThe API forwards the question to the configured DrugCentral retrieval-augmented generation (RAG) service, which returns an AI-generated answer.
- Explore the answerThe app resolves cited drug-card names and displays the answer with links to drug records.
Using the assistant
Each request is independent; previous questions are not sent as conversation history. You can edit a sample before submitting, retry a failed request, or switch back to normal search. Drug links open in a new tab so your question and answer stay available.
Answers may contain mistakes or omit information. Verify details against DrugCentral records and original sources.
AI can make mistakes. Verify answers against the original sources before relying on them.
zuranolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids not used as glucocorticosteroids | 5738 | 1632051-40-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The mechanism of action of zuranolone in the treatment of PPD is not fully understood, but is thought to be related to its positive allosteric modulation of GABAA receptors.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | CDK5,EIF2AK3,GRK2,PDK1,PDK2,PDK4,PRKDC | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 4, 2023 | FDA | SAGE THERAP |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Somnolence | 584.41 | 78.30 | 183 | 1124 | 208901 | 90418239 |
| Dizziness | 181.60 | 78.30 | 109 | 1198 | 589175 | 90037965 |
| Sedation | 165.45 | 78.30 | 50 | 1257 | 48121 | 90579019 |
| Therapy cessation | 143.28 | 78.30 | 42 | 1265 | 36319 | 90590821 |
| Suicidal ideation | 129.06 | 78.30 | 46 | 1261 | 73809 | 90553331 |
| Feeling drunk | 93.72 | 78.30 | 20 | 1287 | 4738 | 90622402 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Somnolence | 342.65 | 85.13 | 114 | 729 | 297335 | 110291121 |
| Therapy cessation | 137.46 | 85.13 | 37 | 806 | 44820 | 110543636 |
| Dizziness | 126.29 | 85.13 | 73 | 770 | 698120 | 109890336 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AX31 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D011619 | Psychotropic Drugs |
| FDA MoA | N0000193997 | GABA A Receptor Positive Modulators |
| FDA EPC | N0000194006 | Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:35623 | anticonvulsant |
| CHEBI has role | CHEBI:50268 | GABA modulator |
Related Drugs by ATC class:
N06AX Other antidepressants 28 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Postpartum depression | indication | 58703003 | DOID:9478 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 20MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | 10172871 | April 17, 2034 | METHOD OF TREATING POSTPARTUM DEPRESSION |
| 20MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | 10342810 | April 17, 2034 | METHOD OF TREATING POSTPARTUM DEPRESSION |
| 25MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | 10172871 | April 17, 2034 | METHOD OF TREATING POSTPARTUM DEPRESSION |
| 25MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | 10342810 | April 17, 2034 | METHOD OF TREATING POSTPARTUM DEPRESSION |
| 30MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | 10172871 | April 17, 2034 | METHOD OF TREATING POSTPARTUM DEPRESSION |
| 30MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | 10342810 | April 17, 2034 | METHOD OF TREATING POSTPARTUM DEPRESSION |
| 20MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | 11884696 | Aug. 23, 2037 | METHOD OF TREATING POSTPARTUM DEPRESSION |
| 25MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | 11884696 | Aug. 23, 2037 | METHOD OF TREATING POSTPARTUM DEPRESSION |
| 30MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | 11884696 | Aug. 23, 2037 | METHOD OF TREATING POSTPARTUM DEPRESSION |
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 20MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | Oct. 31, 2028 | NEW CHEMICAL ENTITY |
| 25MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | Oct. 31, 2028 | NEW CHEMICAL ENTITY |
| 30MG | ZURZUVAE | BIOGEN | N217369 | Oct. 31, 2023 | RX | CAPSULE | ORAL | Oct. 31, 2028 | NEW CHEMICAL ENTITY |
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | ALLOSTERIC MODULATOR | EC50 | 6.37 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| GABA A receptor alpha-4/beta-3/delta | Ion channel | ALLOSTERIC MODULATOR | EC50 | 6.93 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| CHEBI:228302 | CHEBI |
| CHEMBL4105630 | ChEMBL_ID |
| C000634505 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12858 | IUPHAR_LIGAND_ID |
| DB15490 | DRUGBANK_ID |
| 4042740 | VANDF |
| C5227595 | UMLSCUI |
| 10896 | INN_ID |
| 86294073 | PUBCHEM_CID |
| 371468 | MMSL |
| 41988 | MMSL |
| d10110 | MMSL |
| 019513 | NDDF |
| D11793 | KEGG_DRUG |
| 7ZW49N180B | UNII |
| 2669905 | RXNORM |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| ZURZUVAE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64406-029 | CAPSULE | 20 mg | ORAL | NDA | 35 sections |
| ZURZUVAE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64406-029 | CAPSULE | 20 mg | ORAL | NDA | 35 sections |
| ZURZUVAE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64406-030 | CAPSULE | 25 mg | ORAL | NDA | 35 sections |
| ZURZUVAE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64406-030 | CAPSULE | 25 mg | ORAL | NDA | 35 sections |
| ZURZUVAE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64406-031 | CAPSULE | 30 mg | ORAL | NDA | 35 sections |
| ZURZUVAE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64406-031 | CAPSULE | 30 mg | ORAL | NDA | 35 sections |