secukinumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
human origin 4934 1229022-83-6

Description:

MoleculeDescription

Synonyms:

  • secukinumab
  • cosentyx
  • AIN-457
  • AIN457
Secukinumab is a human IgG1 monoclonal antibody that selectively binds to the interleukin-17A (IL-17A) cytokine and inhibits its interaction with the IL-17 receptor. IL-17A is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Secukinumab inhibits the release of proinflammatory cytokines and chemokines.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
10 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Dec. 26, 2014 PMDA Novartis Pharma
Jan. 21, 2015 FDA NOVARTIS PHARMS CORP
Jan. 14, 2015 EMA NOVARTIS EUROPHARM LIMITED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1156.32 16.43 17 391775 287829 89948826
Acute kidney injury 1145.27 16.43 58 391734 320329 89916326
Anaemia 1039.06 16.43 146 391646 352656 89883999
Drug interaction 1000.97 16.43 46 391746 276407 89960248
Liver injury 999.27 16.43 2249 389543 168318 90068337
Psoriasis 937.68 16.43 2012 389780 145742 90090913
Hypotension 885.80 16.43 167 391625 325230 89911425
Fibromyalgia 853.00 16.43 2382 389410 203887 90032768
Neutropenia 812.19 16.43 38 391754 224866 90011789
Type 2 diabetes mellitus 797.40 16.43 2303 389489 200941 90035714
Rheumatic fever 771.54 16.43 1904 389888 151217 90085438
Lip dry 751.72 16.43 1469 390323 99486 90137169
Facet joint syndrome 746.42 16.43 1443 390349 96946 90139709
Constipation 741.86 16.43 154 391638 280241 89956414
Musculoskeletal stiffness 737.98 16.43 2882 388910 293650 89943005
Folliculitis 686.53 16.43 2193 389599 202160 90034495
Death 662.87 16.43 599 391193 455952 89780703
Febrile neutropenia 650.72 16.43 6 391786 158343 90078312
Bursitis 632.61 16.43 1608 390184 130046 90106609
Mobility decreased 631.00 16.43 2446 389346 248288 89988367
Joint range of motion decreased 626.26 16.43 1632 390160 134011 90102644
Injury 618.05 16.43 2068 389724 195281 90041374
Inflammation 611.14 16.43 1929 389863 176663 90059992
Duodenal ulcer perforation 610.94 16.43 2224 389568 219064 90017591
Skin plaque 599.90 16.43 429 391363 9546 90227109
Gait inability 598.89 16.43 1685 390107 144771 90091884
Helicobacter infection 586.29 16.43 2232 389560 224618 90012037
Glossodynia 580.76 16.43 2840 388952 318939 89917716
Somnolence 573.66 16.43 105 391687 208979 90027676
Synovitis 570.76 16.43 2876 388916 326876 89909779
Peripheral venous disease 568.30 16.43 1174 390618 82747 90153908
Wound 561.04 16.43 2694 389098 300286 89936369
Rheumatoid arthritis 548.48 16.43 3047 388745 359567 89877088
Blood cholesterol increased 541.87 16.43 2052 389740 205960 90030695
Pemphigus 538.62 16.43 2812 388980 324052 89912603
Wound infection 536.70 16.43 1324 390468 105078 90131577
Hand deformity 532.77 16.43 2613 389179 293749 89942906
Dehydration 530.55 16.43 99 391693 194348 90042307
Systemic lupus erythematosus 524.88 16.43 3007 388785 358889 89877766
C-reactive protein abnormal 518.87 16.43 1464 390328 125965 90110690
Pericarditis 517.45 16.43 2426 389366 267725 89968930
Hyponatraemia 511.63 16.43 14 391778 133524 90103131
Night sweats 499.70 16.43 1454 390338 127312 90109343
Grip strength decreased 497.98 16.43 1181 390611 91395 90145260
Swollen joint count increased 491.87 16.43 1317 390475 109889 90126766
Disease progression 489.54 16.43 53 391739 156562 90080093
Irritable bowel syndrome 487.28 16.43 1981 389811 205467 90031188
Obesity 485.43 16.43 1268 390524 104239 90132416
Therapeutic product effect incomplete 475.74 16.43 1877 389915 192019 90044636
Osteoarthritis 475.61 16.43 1889 389903 193841 90042814
Platelet count decreased 470.09 16.43 31 391761 136938 90099717
Rheumatoid factor positive 468.37 16.43 1719 390073 169931 90066724
Haemoglobin decreased 467.16 16.43 71 391721 161885 90074770
Anti-cyclic citrullinated peptide antibody positive 462.07 16.43 2136 389656 234297 90002358
Muscle injury 456.94 16.43 1739 390053 174915 90061740
Breast cancer stage III 454.95 16.43 1078 390714 83369 90153286
White blood cell count decreased 449.67 16.43 88 391704 167021 90069634
Malignant neoplasm progression 434.64 16.43 5 391787 106865 90129790
Pancytopenia 416.33 16.43 26 391766 120237 90116418
Dyspnoea 413.39 16.43 2184 389608 878771 89357884
Device malfunction 410.75 16.43 480 391312 20497 90216158
Thrombocytopenia 409.23 16.43 195 391597 208530 90028125
Seizure 403.11 16.43 84 391708 152545 90084110
Blister 396.72 16.43 2160 389632 252838 89983817
Cardiac arrest 391.19 16.43 14 391778 104921 90131734
Hypercholesterolaemia 389.19 16.43 1137 390655 99755 90136900
Respiratory failure 386.02 16.43 34 391758 118384 90118271
Nail disorder 384.28 16.43 813 390979 58254 90178401
Tremor 383.13 16.43 95 391697 153078 90083577
Therapy interrupted 376.27 16.43 732 391060 49376 90187279
Sepsis 374.53 16.43 154 391638 179660 90056995
Dry mouth 373.71 16.43 1682 390110 182377 90054278
Nasopharyngitis 368.92 16.43 3013 388779 404091 89832564
Lung disorder 365.14 16.43 1448 390344 148435 90088220
Arthropathy 361.11 16.43 2764 389028 363478 89873177
Oxygen saturation decreased 361.07 16.43 27 391765 107456 90129199
Treatment failure 359.53 16.43 2397 389395 301531 89935124
Psoriatic arthropathy 359.06 16.43 1940 389852 226395 90010260
Deep vein thrombosis postoperative 358.97 16.43 883 390909 69926 90166729
Renal failure 358.80 16.43 66 391726 130941 90105714
Impaired healing 354.30 16.43 1969 389823 232230 90004425
Wheezing 351.80 16.43 1989 389803 236091 90000564
Lower respiratory tract infection 348.83 16.43 2061 389731 248598 89988057
Neuropathy peripheral 344.42 16.43 84 391708 136886 90099769
Nausea 343.95 16.43 3110 388682 1107206 89129449
Pulmonary embolism 343.40 16.43 73 391719 130747 90105908
Syncope 340.21 16.43 78 391714 132585 90104070
Cardiac failure 339.75 16.43 38 391754 109458 90127197
Intentional overdose 331.77 16.43 18 391774 93816 90142839
Hypoaesthesia 329.26 16.43 2406 389386 311804 89924851
Bradycardia 328.01 16.43 7 391785 83840 90152815
Lower limb fracture 326.84 16.43 957 390835 84056 90152599
Autoimmune disorder 326.35 16.43 896 390896 75848 90160807
Dislocation of vertebra 319.50 16.43 731 391061 55237 90181418
Drug abuse 317.78 16.43 8 391784 82339 90154316
Fall 313.67 16.43 1052 390740 480758 89755897
Road traffic accident 307.97 16.43 1095 390697 106531 90130124
Stomatitis 301.94 16.43 2128 389664 272570 89964085
Incorrect dose administered 297.20 16.43 882 390910 78048 90158607
Blepharospasm 296.63 16.43 706 391086 54739 90181916
Drug ineffective 294.17 16.43 7939 383853 1376359 88860296
Depressed level of consciousness 293.31 16.43 4 391788 72780 90163875
Urticaria 291.43 16.43 2330 389462 310404 89926251
Cardiac failure congestive 289.81 16.43 41 391751 98653 90138002
Skin exfoliation 288.86 16.43 793 390999 67120 90169535
Atrial fibrillation 288.80 16.43 108 391684 133503 90103152
Neutrophil count decreased 283.73 16.43 5 391787 71527 90165128
Sciatica 282.85 16.43 1023 390769 100359 90136296
Gastrointestinal haemorrhage 280.80 16.43 31 391761 90217 90146438
Prescribed overdose 279.10 16.43 993 390799 96632 90140023
C-reactive protein increased 277.54 16.43 1530 390262 179859 90056796
Musculoskeletal pain 276.57 16.43 1466 390326 169785 90066870
Incorrect dose administered by device 276.35 16.43 216 391576 5521 90231134
Back injury 276.21 16.43 618 391174 46004 90190651
Ill-defined disorder 275.89 16.43 1549 390243 183342 90053313
General physical health deterioration 275.41 16.43 2540 389252 352575 89884080
Swelling 275.20 16.43 2895 388897 416163 89820492
Onychomadesis 273.94 16.43 611 391181 45387 90191268
Live birth 273.55 16.43 858 390934 78249 90158406
Balance disorder 272.16 16.43 46 391746 97034 90139621
Inappropriate schedule of product administration 268.29 16.43 1321 390471 148612 90088043
Adjustment disorder with depressed mood 267.01 16.43 688 391104 56065 90180590
Joint swelling 256.17 16.43 3310 388482 499990 89736665
Sleep disorder 254.90 16.43 1596 390196 196434 90040221
Product label confusion 254.13 16.43 397 391395 22453 90214202
Hallucination 252.29 16.43 7 391785 65952 90170703
Multiple organ dysfunction syndrome 251.67 16.43 10 391782 68326 90168329
Macule 251.45 16.43 152 391640 2517 90234138
X-ray abnormal 251.25 16.43 586 391206 44838 90191817
Coma 250.48 16.43 16 391776 72616 90164039
Hypoxia 246.58 16.43 17 391775 72382 90164273
Hyperkalaemia 244.47 16.43 8 391784 64956 90171699
Cardio-respiratory arrest 244.14 16.43 6 391786 63134 90173521
Liver disorder 243.60 16.43 1105 390687 120164 90116491
Pulmonary fibrosis 238.33 16.43 1009 390783 106494 90130161
Discomfort 237.80 16.43 2011 389781 272324 89964331
Gastrointestinal disorder 237.70 16.43 1910 389882 254777 89981878
Papule 236.58 16.43 228 391564 7774 90228881
Liver function test increased 232.25 16.43 851 390941 84004 90152651
Pleural effusion 231.39 16.43 97 391695 111894 90124761
C-reactive protein 229.13 16.43 453 391339 30914 90205741
Taste disorder 227.19 16.43 683 391109 60863 90175792
Myalgia 226.00 16.43 254 391538 174871 90061784
Hepatic enzyme increased 225.95 16.43 2469 389323 358267 89878388
Hypokalaemia 225.74 16.43 144 391648 130972 90105683
Hypoglycaemia 222.43 16.43 22 391770 69826 90166829
Suicide attempt 219.79 16.43 32 391760 75367 90161288
Cognitive disorder 215.53 16.43 24 391768 69383 90167272
Interstitial lung disease 214.62 16.43 36 391756 76369 90160286
Therapeutic product effect decreased 214.36 16.43 1984 389808 275587 89961068
Agitation 214.02 16.43 21 391771 67077 90169578
Sleep disorder due to general medical condition, insomnia type 212.75 16.43 1109 390683 127585 90109070
Metabolic acidosis 212.61 16.43 6 391786 55670 90180985
Epistaxis 212.42 16.43 53 391739 85072 90151583
Vision blurred 208.60 16.43 108 391684 110185 90126470
Incorrect route of product administration 208.21 16.43 584 391208 50042 90186613
Retinitis 207.10 16.43 491 391301 37967 90198688
Drug intolerance 206.32 16.43 2892 388900 444699 89791956
Rhabdomyolysis 205.74 16.43 3 391789 51253 90185402
Finger deformity 201.54 16.43 442 391350 32455 90204200
Alopecia 201.27 16.43 3130 388662 491941 89744714
Hyperhidrosis 200.80 16.43 176 391616 136129 90100526
Renal impairment 199.72 16.43 103 391689 105318 90131337
Intentional product misuse 199.45 16.43 69 391723 89535 90147120
Abdominal discomfort 196.38 16.43 3024 388768 474304 89762351
Contraindicated product administered 194.84 16.43 2179 389613 317960 89918695
Accidental exposure to product 194.56 16.43 509 391283 41857 90194798
Arthralgia 194.54 16.43 4567 387225 773955 89462700
Lactic acidosis 194.33 16.43 5 391787 50458 90186197
Intentional product use issue 194.31 16.43 1602 390190 215290 90021365
Overdose 192.50 16.43 239 391553 157470 90079185
Pulmonary oedema 191.42 16.43 22 391770 62058 90174597
Arthritis 190.63 16.43 1308 390484 166007 90070648
International normalised ratio increased 188.94 16.43 3 391789 47313 90189342
Blood pressure decreased 184.25 16.43 48 391744 74847 90161808
Maternal exposure during pregnancy 184.20 16.43 2371 389421 357692 89878963
Hyperglycaemia 182.62 16.43 9 391783 50961 90185694
Dyspnoea exertional 182.34 16.43 44 391748 72244 90164411
Neck pain 180.10 16.43 970 390822 112993 90123662
Myocardial infarction 177.51 16.43 120 391672 105852 90130803
Encephalopathy 177.37 16.43 5 391787 46439 90190216
Injection site erythema 175.36 16.43 104 391688 98398 90138257
Heart rate increased 173.40 16.43 140 391652 112762 90123893
Loss of consciousness 172.76 16.43 211 391581 140027 90096628
Lupus vulgaris 171.94 16.43 506 391286 44553 90192102
Flushing 171.32 16.43 84 391708 88407 90148248
Onychomycosis 170.55 16.43 448 391344 36928 90199727
Multiple sclerosis relapse 170.48 16.43 15 391777 52290 90184365
Tachycardia 170.31 16.43 261 391531 157412 90079243
Deep vein thrombosis 169.89 16.43 92 391700 91528 90145127
Heart rate decreased 164.88 16.43 19 391773 53486 90183169
Blood glucose increased 164.77 16.43 104 391688 95142 90141513
Bone erosion 163.38 16.43 553 391239 52468 90184187
Off label use 162.90 16.43 3581 388211 1098671 89137984
Skin lesion 162.54 16.43 440 391352 36925 90199730
Migraine 161.86 16.43 1390 390402 189002 90047653
Therapy non-responder 161.85 16.43 1079 390713 135625 90101030
Pustular psoriasis 160.40 16.43 288 391504 18268 90218387
Mucosal inflammation 159.98 16.43 28 391764 57597 90179058
Laryngitis 157.85 16.43 531 391261 50222 90186433
Mental status changes 156.60 16.43 9 391783 44670 90191985
Inflammatory bowel disease 156.02 16.43 149 391643 5022 90231633
Thrombosis 155.29 16.43 61 391731 73190 90163465
Drug reaction with eosinophilia and systemic symptoms 154.97 16.43 7 391785 42751 90193904
Blood bilirubin increased 154.71 16.43 8 391784 43462 90193193
Device issue 154.61 16.43 373 391419 29164 90207491
Breast cancer stage II 153.62 16.43 416 391376 34918 90201737
Blood pressure fluctuation 153.33 16.43 22 391770 52391 90184264
Exostosis 152.27 16.43 541 391251 52593 90184062
Hepatic function abnormal 151.61 16.43 13 391779 46275 90190380
Neoplasm progression 149.88 16.43 11 391781 44475 90192180
Epilepsy 149.62 16.43 728 391064 81478 90155177
Enthesopathy 148.30 16.43 193 391599 9211 90227444
Blood creatinine increased 148.01 16.43 132 391660 101254 90135401
Skin haemorrhage 146.87 16.43 301 391491 21079 90215576
Acute respiratory failure 146.37 16.43 10 391782 42908 90193747
Orthostatic hypotension 144.86 16.43 9 391783 41818 90194837
Product use issue 144.78 16.43 2114 389678 327805 89908850
Aspartate aminotransferase increased 143.22 16.43 140 391652 102797 90133858
Adverse reaction 142.63 16.43 363 391429 29349 90207306
Leukopenia 142.41 16.43 135 391657 100575 90136080
Unresponsive to stimuli 142.36 16.43 5 391787 38116 90198539
Red blood cell sedimentation rate increased 142.20 16.43 720 391072 81875 90154780
Oedema 141.82 16.43 1406 390386 198889 90037766
Blood pressure increased 139.03 16.43 415 391377 196802 90039853
Alanine aminotransferase increased 138.55 16.43 185 391607 118153 90118502
Malaise 138.32 16.43 3412 388380 582574 89654081
Sinusitis 138.02 16.43 2166 389626 340922 89895733
Chronic kidney disease 138.00 16.43 25 391767 50166 90186489
Device defective 137.87 16.43 117 391675 3369 90233286
Disturbance in attention 137.28 16.43 20 391772 47089 90189566
Osteonecrosis of jaw 136.67 16.43 8 391784 39095 90197560
Pulmonary hypertension 136.43 16.43 13 391779 42510 90194145
Septic shock 136.06 16.43 99 391693 84061 90152594
Cholestasis 134.72 16.43 5 391787 36294 90200361
Chronic obstructive pulmonary disease 134.18 16.43 76 391716 73753 90162902
Plasma cell myeloma 132.28 16.43 12 391780 40816 90195839
Red blood cell count decreased 132.05 16.43 21 391771 46330 90190325
Ascites 130.79 16.43 24 391768 47716 90188939
Disorientation 130.26 16.43 18 391774 44096 90192559
Rash maculo-papular 130.05 16.43 13 391779 40920 90195735
Pallor 129.29 16.43 4 391788 34161 90202494
Dactylitis 129.17 16.43 118 391674 3755 90232900
Product use in unapproved indication 128.95 16.43 2106 389686 334130 89902525
Generalised tonic-clonic seizure 128.88 16.43 5 391787 34898 90201757
Blood potassium decreased 128.60 16.43 25 391767 47702 90188953
Melaena 128.44 16.43 5 391787 34792 90201863
Pneumonitis 128.14 16.43 19 391773 44151 90192504
Blood alkaline phosphatase increased 127.84 16.43 26 391766 48053 90188602
Cough 127.20 16.43 1003 390789 367959 89868696
Peripheral swelling 127.14 16.43 2499 389293 410607 89826048
Chills 126.37 16.43 236 391556 131745 90104910
Respiratory arrest 125.70 16.43 4 391788 33307 90203348
Urinary retention 125.28 16.43 10 391782 37734 90198921
Lupus-like syndrome 124.59 16.43 479 391313 48367 90188288
Pericardial effusion 124.40 16.43 9 391783 36824 90199831
Memory impairment 123.74 16.43 1351 390441 195893 90040762
Ear infection 123.46 16.43 613 391179 69162 90167493
Macular degeneration 123.45 16.43 11 391781 37959 90198696
Full blood count abnormal 123.44 16.43 9 391783 36588 90200067
Hypervolaemia 123.37 16.43 4 391788 32753 90203902
Toxic epidermal necrolysis 122.41 16.43 4 391788 32524 90204131
Bone marrow failure 121.12 16.43 4 391788 32217 90204438
Prescribed underdose 120.85 16.43 642 391150 74377 90162278
Product quality issue 120.47 16.43 668 391124 78657 90157998
Dyskinesia 120.37 16.43 10 391782 36524 90200131
Hypothyroidism 119.81 16.43 40 391752 53087 90183568
Altered state of consciousness 118.22 16.43 4 391788 31528 90205127
Premature delivery 116.40 16.43 15 391777 38747 90197908
Dysgeusia 116.06 16.43 41 391751 52519 90184136
Infection 115.66 16.43 2203 389589 359891 89876764
Pneumonia aspiration 115.62 16.43 19 391773 40921 90195734
Haematocrit decreased 114.66 16.43 21 391771 41811 90194844
Hypophagia 112.65 16.43 12 391780 35925 90200730
Coeliac disease 112.58 16.43 436 391356 44174 90192481
Angioedema 111.98 16.43 71 391721 64805 90171850
Liver function test abnormal 111.69 16.43 40 391752 50805 90185850
Ulcer haemorrhage 111.54 16.43 307 391485 26014 90210641
Device dislocation 111.39 16.43 6 391786 31476 90205179
Pancreatitis acute 110.95 16.43 7 391785 32108 90204547
Foetal exposure during pregnancy 110.67 16.43 25 391767 42950 90193705
Full blood count decreased 110.49 16.43 4 391788 29685 90206970
Psychotic disorder 110.35 16.43 6 391786 31224 90205431
Adverse event 110.33 16.43 877 390915 116541 90120114
Presyncope 109.67 16.43 7 391785 31798 90204857
Dyspepsia 107.20 16.43 1319 390473 196841 90039814
Lymphocyte count decreased 106.62 16.43 13 391779 35037 90201618
Blood calcium decreased 106.02 16.43 6 391786 30176 90206479
Stevens-Johnson syndrome 105.84 16.43 5 391787 29371 90207284
Drug ineffective for unapproved indication 105.66 16.43 80 391712 66564 90170091
Urinary incontinence 104.83 16.43 18 391774 37548 90199107
Product storage error 104.22 16.43 254 391538 19987 90216668
Respiratory distress 103.68 16.43 21 391771 38925 90197730
Device leakage 103.41 16.43 168 391624 9823 90226832
Shock 103.36 16.43 5 391787 28773 90207882
Pain in jaw 103.30 16.43 39 391753 47946 90188709
Neurologic neglect syndrome 102.98 16.43 157 391635 8690 90227965
Hepatotoxicity 102.53 16.43 35 391757 45807 90190848
Seborrhoeic keratosis 102.39 16.43 95 391697 3085 90233570
Cerebral haemorrhage 102.13 16.43 14 391778 34508 90202147
Hypersensitivity 101.40 16.43 2628 389164 452049 89784606
Guttate psoriasis 101.26 16.43 50 391742 541 90236114
Transient ischaemic attack 100.03 16.43 31 391761 43145 90193510
Carotid artery thrombosis 99.75 16.43 157 391635 8935 90227720
Unevaluable event 98.90 16.43 57 391735 54791 90181864
Femur fracture 98.29 16.43 38 391754 46044 90190611
Muscular weakness 98.09 16.43 1343 390449 205323 90031332
Hepatocellular injury 98.02 16.43 7 391785 28951 90207704
Haematoma 98.02 16.43 24 391768 39024 90197631
Blood creatine phosphokinase increased 97.86 16.43 15 391777 34008 90202647
Porphyria acute 97.32 16.43 230 391562 17745 90218910
Hypomagnesaemia 97.25 16.43 18 391774 35570 90201085
Haematemesis 96.71 16.43 15 391777 33711 90202944
Sinus tachycardia 96.20 16.43 7 391785 28506 90208149
Maternal exposure timing unspecified 96.03 16.43 263 391529 22220 90214435
Tubulointerstitial nephritis 95.78 16.43 3 391789 25340 90211315
Hepatic failure 94.82 16.43 27 391765 39701 90196954
Cytomegalovirus infection 94.34 16.43 5 391787 26597 90210058
Abdominal pain upper 93.54 16.43 1986 389806 330688 89905967
Arrhythmia 93.50 16.43 33 391759 42299 90194356
Eosinophilia 93.48 16.43 8 391784 28525 90208130
Blood urea increased 93.21 16.43 11 391781 30402 90206253
Intestinal obstruction 92.86 16.43 23 391769 37108 90199547
Acute respiratory distress syndrome 91.42 16.43 9 391783 28677 90207978
Lethargy 91.19 16.43 83 391709 63056 90173599
Chest discomfort 90.56 16.43 301 391491 138064 90098591
Hepatic cirrhosis 90.33 16.43 524 391268 62729 90173926
Bone pain 90.09 16.43 81 391711 61902 90174753
Subcutaneous drug absorption impaired 89.87 16.43 188 391604 13357 90223298
Jaundice 89.82 16.43 16 391776 32501 90204154
Ventricular tachycardia 89.69 16.43 4 391788 24704 90211951
Tinnitus 89.55 16.43 37 391755 43065 90193590
Adjustment disorder 88.96 16.43 154 391638 9488 90227167
Aggression 88.69 16.43 7 391785 26661 90209994
Cardiogenic shock 88.69 16.43 4 391788 24464 90212191
Rebound psoriasis 88.54 16.43 31 391761 124 90236531
Hepatic cytolysis 88.08 16.43 14 391778 30902 90205753
Premature baby 88.04 16.43 5 391787 25072 90211583
Infusion related reaction 87.73 16.43 2391 389401 414389 89822266
Back pain 87.54 16.43 912 390880 316263 89920392
Food allergy 86.70 16.43 6 391786 25472 90211183
Infusion site reaction 86.64 16.43 228 391564 18811 90217844
Hallucination, visual 86.33 16.43 3 391789 23089 90213566
Drug resistance 86.28 16.43 14 391778 30435 90206220
Wrong technique in device usage process 86.22 16.43 116 391676 5719 90230936
Blood lactate dehydrogenase increased 85.71 16.43 7 391785 25925 90210730
Delirium 84.52 16.43 754 391038 103605 90133050
Muscle twitching 84.44 16.43 5 391787 24197 90212458
Haematochezia 83.87 16.43 110 391682 70803 90165852
Drug tolerance decreased 83.51 16.43 317 391475 31813 90204842
Anti-cyclic citrullinated peptide antibody 83.04 16.43 283 391509 26938 90209717
Upper gastrointestinal haemorrhage 82.49 16.43 4 391788 22972 90213683
Device related infection 82.41 16.43 8 391784 25778 90210877
Urinary tract infection 81.84 16.43 885 390907 304747 89931908
Seronegative arthritis 81.60 16.43 217 391575 18017 90218638
Gamma-glutamyltransferase increased 81.44 16.43 31 391761 37921 90198734
Hidradenitis 81.00 16.43 97 391695 4250 90232405
Swelling face 80.96 16.43 142 391650 81210 90155445
Cholelithiasis 80.74 16.43 65 391727 52441 90184214
Coagulopathy 80.68 16.43 5 391787 23284 90213371
Obstructive airways disorder 80.17 16.43 9 391783 25860 90210795
Lentigo 79.98 16.43 44 391748 604 90236051
Electrolyte imbalance 79.63 16.43 6 391786 23739 90212916
Injection site swelling 79.12 16.43 85 391707 59754 90176901
Tachypnoea 78.86 16.43 3 391789 21306 90215349
Haemorrhage 78.61 16.43 111 391681 69258 90167397
Palpitations 78.56 16.43 314 391478 136414 90100241
Acute hepatic failure 77.69 16.43 5 391787 22556 90214099
Blood sodium decreased 77.56 16.43 13 391779 27600 90209055
Mitral valve incompetence 77.54 16.43 5 391787 22519 90214136
Injection site pruritus 77.47 16.43 71 391721 53763 90182892
Acute myocardial infarction 77.40 16.43 27 391765 34863 90201792
Procedural pain 77.20 16.43 24 391768 33336 90203319
Myelodysplastic syndrome 77.16 16.43 3 391789 20900 90215755
Transaminases increased 77.15 16.43 32 391760 37160 90199495
Weight decreased 76.89 16.43 1167 390625 378743 89857912
Needle issue 76.20 16.43 179 391613 13755 90222900
Suicidal ideation 76.17 16.43 126 391666 73729 90162926
Acute myeloid leukaemia 76.06 16.43 3 391789 20637 90216018
Device delivery system issue 75.13 16.43 62 391730 1716 90234939
Amnesia 74.96 16.43 758 391034 107747 90128908
Atelectasis 74.38 16.43 9 391783 24400 90212255
Circulatory collapse 73.91 16.43 10 391782 24894 90211761
Pustule 73.87 16.43 76 391716 2807 90233848
Cerebral infarction 73.65 16.43 13 391779 26583 90210072
Tooth disorder 72.60 16.43 22 391770 31068 90205587
Dry eye 72.55 16.43 86 391706 57845 90178810
Abnormal behaviour 72.37 16.43 7 391785 22621 90214034
Clostridium difficile infection 72.30 16.43 33 391759 36212 90200443
Chronic sinusitis 71.98 16.43 9 391783 23793 90212862
Withdrawal syndrome 71.96 16.43 7 391785 22517 90214138
Drug dependence 71.74 16.43 19 391773 29308 90207347
Diplopia 71.39 16.43 18 391774 28696 90207959
Paraesthesia oral 71.10 16.43 24 391768 31635 90205020
Pneumocystis jirovecii pneumonia 70.98 16.43 6 391786 21610 90215045
Foot deformity 70.66 16.43 471 391321 59180 90177475
Leukocytosis 70.46 16.43 23 391769 30967 90205688
Nail psoriasis 70.25 16.43 42 391750 681 90235974
Foetal death 70.17 16.43 5 391787 20718 90215937
Tonsillar ulcer 70.10 16.43 32 391760 286 90236369
Ankylosing spondylitis 69.97 16.43 167 391625 12966 90223689
Myoclonus 69.92 16.43 3 391789 19165 90217490
Vulvovaginal candidiasis 69.37 16.43 85 391707 3815 90232840
Tonsillitis 69.18 16.43 115 391677 6854 90229801
Flatulence 69.05 16.43 47 391745 41320 90195335
Blood pressure diastolic decreased 68.29 16.43 16 391776 26810 90209845
Drug tolerance 68.16 16.43 201 391591 17715 90218940
Cardiomyopathy 68.06 16.43 5 391787 20201 90216454
Metastases to liver 67.97 16.43 20 391772 28787 90207868
Normal newborn 67.89 16.43 239 391553 23123 90213532
Anaphylactic reaction 67.72 16.43 176 391616 87348 90149307
Caesarean section 67.46 16.43 3 391789 18574 90218081
Personality disorder 67.12 16.43 159 391633 12285 90224370
Heart rate irregular 66.90 16.43 12 391780 24256 90212399
Retching 66.71 16.43 4 391788 19155 90217500
Underdose 66.71 16.43 431 391361 53586 90183069
Vertigo 66.66 16.43 125 391667 69686 90166969
Adverse drug reaction 66.22 16.43 784 391008 115917 90120738
Bronchiectasis 66.19 16.43 9 391783 22321 90214334
Eye irritation 66.14 16.43 32 391760 33946 90202709
Restlessness 66.02 16.43 36 391756 35684 90200971
Irritability 65.82 16.43 36 391756 35626 90201029
Visual acuity reduced 65.80 16.43 11 391781 23399 90213256
Ataxia 65.23 16.43 3 391789 18039 90218616
Product substitution issue 65.09 16.43 3 391789 18005 90218650
Cyanosis 65 16.43 5 391787 19450 90217205
Complication associated with device 64.98 16.43 5 391787 19444 90217211
Vomiting 64.75 16.43 2768 389024 785525 89451130
Hot flush 64.66 16.43 98 391694 59390 90177265
Pain 64.62 16.43 5070 386722 991271 89245384
Pain in extremity 64.62 16.43 2469 389323 448060 89788595
Product dose omission issue 64.61 16.43 880 390912 290807 89945848
Rash vesicular 64.37 16.43 199 391593 17998 90218657
Drug-induced liver injury 64.34 16.43 635 391157 89683 90146972
Mycotic allergy 64.06 16.43 46 391746 1030 90235625
Bacteraemia 63.75 16.43 10 391782 22290 90214365
Treatment noncompliance 63.49 16.43 78 391714 51649 90185006
Renal disorder 63.21 16.43 43 391749 37816 90198839
Hypertension 63.17 16.43 2497 389295 455035 89781620
Transfusion 62.93 16.43 3 391789 17485 90219170
Cardiac murmur 62.75 16.43 4 391788 18190 90218465
Haemangioma of skin 62.71 16.43 38 391754 632 90236023
Joint stiffness 62.23 16.43 562 391230 77480 90159175
Joint dislocation 62.14 16.43 367 391425 44215 90192440
Sinus congestion 61.98 16.43 259 391533 27165 90209490
Skin laceration 61.57 16.43 18 391774 26017 90210638
Joint destruction 61.36 16.43 160 391632 13127 90223528
Dementia 61.20 16.43 14 391778 23847 90212808
Proteinuria 61.09 16.43 13 391779 23278 90213377
Sacroiliitis 61.01 16.43 83 391709 4136 90232519
Spondyloarthropathy 60.94 16.43 47 391745 1177 90235478
Ejection fraction decreased 60.55 16.43 19 391773 26234 90210421
Feeling abnormal 60.19 16.43 449 391343 166786 90069869
General symptom 60.09 16.43 169 391623 14499 90222156
Vaginal haemorrhage 60.04 16.43 30 391762 31241 90205414
Head injury 59.76 16.43 30 391762 31158 90205497
Peritonitis 58.27 16.43 8 391784 19697 90216958
Eye pain 58.11 16.43 63 391729 44105 90192550
Lymphopenia 57.55 16.43 14 391778 22867 90213788
Cytopenia 56.87 16.43 5 391787 17444 90219211
Ischaemic stroke 56.87 16.43 13 391779 22153 90214502
Hallucination, auditory 56.66 16.43 3 391789 15972 90220683
Confusional state 56.19 16.43 2120 389672 384085 89852570
Ileus 56 16.43 4 391788 16542 90220113
Blood glucose decreased 55.77 16.43 16 391776 23413 90213242
Abdominal pain 55.69 16.43 1294 390498 394427 89842228
Diarrhoea 55.63 16.43 3410 388382 935780 89300875
Bronchospasm 55.47 16.43 11 391781 20698 90215957
Poor venous access 55.28 16.43 9 391783 19518 90217137
Nightmare 55.22 16.43 13 391779 21712 90214943
Herpes zoster 55.22 16.43 216 391576 94428 90142227
Coronary artery disease 55.06 16.43 39 391753 33584 90203071
Hip arthroplasty 54.87 16.43 537 391255 75671 90160984
Contusion 54.72 16.43 1448 390344 249768 89986887
Arterial occlusive disease 54.56 16.43 147 391645 12299 90224356
Polyneuropathy 54.56 16.43 9 391783 19332 90217323
Injection site warmth 54.51 16.43 6 391786 17509 90219146
Axial spondyloarthritis 54.51 16.43 34 391758 597 90236058
Hypocalcaemia 54.02 16.43 62 391730 42306 90194349
Respiratory rate increased 53.78 16.43 4 391788 15997 90220658
Subdural haematoma 53.63 16.43 5 391787 16640 90220015
Urosepsis 53.39 16.43 13 391779 21219 90215436
Hip fracture 53.34 16.43 39 391753 33038 90203617
Metastases to bone 52.81 16.43 22 391770 25483 90211172
Blood magnesium decreased 52.52 16.43 4 391788 15689 90220966
Gangrene 52.40 16.43 148 391644 12728 90223927
Metastases to central nervous system 52.16 16.43 7 391785 17535 90219120
Hyperlipidaemia 52.11 16.43 17 391775 22899 90213756
Cardiac disorder 51.55 16.43 105 391687 56767 90179888
Haemoptysis 51.54 16.43 41 391751 33279 90203376
Anaphylactic shock 51.35 16.43 37 391755 31580 90205075
Iron deficiency anaemia 51.32 16.43 19 391773 23643 90213012
Impaired quality of life 51.19 16.43 18 391774 23126 90213529
Metastases to lung 51.00 16.43 5 391787 15986 90220669
Blood pressure systolic increased 50.97 16.43 110 391682 58235 90178420
Fracture 50.87 16.43 16 391776 22060 90214595
Lung infiltration 50.85 16.43 4 391788 15278 90221377
Cardiomegaly 50.80 16.43 10 391782 18915 90217740
Renal tubular necrosis 50.80 16.43 3 391789 14552 90222103
Sleep apnoea syndrome 50.46 16.43 38 391754 31709 90204946
Feeling cold 50.29 16.43 28 391764 27437 90209218
Accidental overdose 50.10 16.43 30 391762 28243 90208412
Uveitis 49.98 16.43 167 391625 15736 90220919
Schizophrenia 49.36 16.43 4 391788 14910 90221745
Spondylitis 49.18 16.43 154 391638 14024 90222631
Lacrimation increased 48.96 16.43 28 391764 27034 90209621
Abortion spontaneous 48.83 16.43 100 391692 53956 90182699
Restless legs syndrome 48.80 16.43 18 391774 22452 90214203
Blindness 48.77 16.43 27 391765 26541 90210114
Pruritus 48.72 16.43 2833 388959 538692 89697963
Cerebrovascular accident 48.69 16.43 323 391469 123210 90113445
Knee arthroplasty 48.59 16.43 562 391230 82620 90154035
Neutrophil count increased 48.51 16.43 12 391780 19378 90217277
Muscle spasms 48.46 16.43 1429 390363 250454 89986201
Dysphagia 48.16 16.43 286 391506 111992 90124663
Hypocholesterolaemia 48.13 16.43 94 391698 6355 90230300
Condition aggravated 48.07 16.43 3086 388706 592459 89644196
Small intestinal obstruction 47.85 16.43 16 391776 21218 90215437
Grip strength 47.76 16.43 114 391678 8851 90227804
Osteonecrosis 47.69 16.43 27 391765 26214 90210441
Toxic skin eruption 47.61 16.43 6 391786 15768 90220887
Petechiae 47.48 16.43 6 391786 15735 90220920
Generalised oedema 47.26 16.43 12 391780 19041 90217614
Rhinitis allergic 46.93 16.43 8 391784 16777 90219878
Haematuria 46.89 16.43 49 391743 34888 90201767
Tricuspid valve incompetence 46.72 16.43 8 391784 16723 90219932
Pseudomonas infection 46.50 16.43 5 391787 14860 90221795
Red blood cell sedimentation rate 46.42 16.43 77 391715 4581 90232074
Clostridium difficile colitis 46.40 16.43 29 391763 26677 90209978
Haemophagocytic lymphohistiocytosis 46.37 16.43 6 391786 15453 90221202
Anuria 46.31 16.43 5 391787 14813 90221842
Neuralgia 45.97 16.43 41 391751 31459 90205196
Hemiplegia 45.82 16.43 164 391628 15996 90220659
Proctitis 45.59 16.43 6 391786 15253 90221402
Muscle spasticity 45.57 16.43 285 391507 35037 90201618
Dermatitis psoriasiform 45.54 16.43 57 391735 2615 90234040
Rib fracture 45.52 16.43 29 391763 26406 90210249
Pelvic fracture 45.43 16.43 6 391786 15213 90221442
Palmoplantar pustulosis 45.41 16.43 30 391762 584 90236071
Radiculopathy 45.24 16.43 12 391780 18493 90218162
Supraventricular tachycardia 45.20 16.43 8 391784 16328 90220327
Eye injury 45.17 16.43 127 391665 10893 90225762
Respiratory tract congestion 45.11 16.43 236 391556 27174 90209481
Creatinine renal clearance decreased 44.81 16.43 13 391779 18886 90217769
Throat irritation 44.05 16.43 90 391702 48605 90188050
Diabetes mellitus inadequate control 44.03 16.43 13 391779 18671 90217984
Spinal fracture 43.98 16.43 20 391772 21996 90214659
Wrong technique in product usage process 43.92 16.43 160 391632 71411 90165244
Mania 43.55 16.43 5 391787 14119 90222536
Gastrooesophageal reflux disease 43.49 16.43 983 390809 165354 90071301
Sensory loss 43.45 16.43 174 391618 17901 90218754
Injection site pain 43.29 16.43 511 391281 173188 90063467
Illness 43.16 16.43 543 391249 81426 90155229
Premature labour 43.14 16.43 4 391788 13372 90223283
Blood potassium increased 42.80 16.43 18 391774 20731 90215924
Breast cancer metastatic 42.78 16.43 7 391785 15125 90221530
Troponin increased 42.76 16.43 4 391788 13277 90223378
Genital candidiasis 42.58 16.43 20 391772 192 90236463
Oedema peripheral 42.50 16.43 822 390970 257093 89979562
Swollen tongue 42.38 16.43 84 391708 45872 90190783
Decreased immune responsiveness 42.11 16.43 107 391685 8641 90228014
Sensory disturbance 41.68 16.43 8 391784 15405 90221250
Vulval disorder 41.07 16.43 39 391753 1305 90235350
Productive cough 40.54 16.43 183 391609 76880 90159775
Stress cardiomyopathy 40.51 16.43 5 391787 13350 90223305
Immune thrombocytopenia 40.39 16.43 5 391787 13321 90223334
Depressed mood 40.39 16.43 99 391693 50123 90186532
Myocardial ischaemia 39.94 16.43 6 391786 13808 90222847
Myocarditis 39.90 16.43 6 391786 13800 90222855
Eye pruritus 39.76 16.43 40 391752 28987 90207668
Swollen joint count 39.76 16.43 104 391688 8549 90228106
Product administration interrupted 39.60 16.43 4 391788 12488 90224167
Hiatus hernia 39.49 16.43 31 391761 25330 90211325
Thirst 39.02 16.43 11 391781 16284 90220371
Poisoning 38.89 16.43 9 391783 15208 90221447
Affect lability 38.81 16.43 168 391624 17895 90218760
Ear injury 38.76 16.43 22 391770 322 90236333
Psychomotor hyperactivity 38.37 16.43 5 391787 12808 90223847
Therapeutic response shortened 38.35 16.43 198 391594 22681 90213974
Injection site rash 38.33 16.43 29 391763 24144 90212511
Walking aid user 38.29 16.43 274 391518 35232 90201423
Speech disorder 38.14 16.43 88 391704 45497 90191158
Cholecystitis 38.12 16.43 13 391779 17027 90219628
Weight increased 38.05 16.43 2189 389603 415738 89820917
Gastritis 37.92 16.43 77 391715 41676 90194979
Colitis ulcerative 37.84 16.43 413 391379 59853 90176802
Hepatitis 37.84 16.43 470 391322 70269 90166386
Throat tightness 37.75 16.43 43 391749 29441 90207214
Rash erythematous 37.71 16.43 149 391643 64955 90171700
Lymphoedema 37.48 16.43 7 391785 13746 90222909
Lower respiratory tract infection viral 37.17 16.43 32 391760 940 90235715
Lipase increased 36.72 16.43 3 391789 11108 90225547
Polyarthritis 36.65 16.43 167 391625 18183 90218472
Wrist fracture 36.58 16.43 11 391781 15613 90221042
Cardiovascular disorder 36.49 16.43 7 391785 13485 90223170
Erythema multiforme 36.14 16.43 5 391787 12241 90224414
Pneumonia bacterial 35.97 16.43 6 391786 12784 90223871
Gastroenteritis 35.95 16.43 44 391748 29185 90207470
Eructation 35.79 16.43 3 391789 10879 90225776
Back disorder 35.72 16.43 211 391581 25420 90211235
Tooth extraction 35.69 16.43 4 391788 11509 90225146
Abdominal pain lower 35.48 16.43 47 391745 30130 90206525
Hypoacusis 35.24 16.43 41 391751 27809 90208846
Carpal tunnel syndrome 35.09 16.43 31 391761 23897 90212758
Therapeutic response unexpected 35.02 16.43 26 391766 21854 90214801
Impaired work ability 34.96 16.43 20 391772 19306 90217349
Dialysis 34.96 16.43 4 391788 11325 90225330
Hypogammaglobulinaemia 34.95 16.43 3 391789 10671 90225984
Blood pressure abnormal 34.59 16.43 21 391771 19624 90217031
Bone density decreased 34.27 16.43 16 391776 17329 90219326
Influenza 34.23 16.43 816 390976 138448 90098207
Incontinence 34.22 16.43 8 391784 13427 90223228
Paraesthesia 34.21 16.43 1365 390427 248961 89987694
Post procedural complication 34.03 16.43 20 391772 19022 90217633
Peripheral coldness 33.98 16.43 9 391783 13883 90222772
Faecaloma 33.97 16.43 3 391789 10428 90226227
Impaired gastric emptying 33.90 16.43 7 391785 12802 90223853
No adverse event 33.66 16.43 165 391627 67817 90168838
Muscle rigidity 33.64 16.43 10 391782 14299 90222356
Pyrexia 33.61 16.43 2430 389362 658055 89578600
Anal incontinence 33.60 16.43 14 391778 16216 90220439
Hyperthermia 33.58 16.43 3 391789 10332 90226323
Lip swelling 33.55 16.43 73 391719 38537 90198118
HLA-B*27 positive 33.44 16.43 18 391774 236 90236419
Seasonal allergy 33.44 16.43 30 391762 22953 90213702
Klebsiella infection 33.43 16.43 3 391789 10294 90226361
Heavy menstrual bleeding 33.37 16.43 24 391768 20506 90216149
Motor dysfunction 33.34 16.43 168 391624 19062 90217593
Hypermobility syndrome 33.31 16.43 29 391763 865 90235790
Facial pain 33.28 16.43 8 391784 13174 90223481
Headache 32.98 16.43 3247 388545 859499 89377156
Aspergillus infection 32.95 16.43 4 391788 10819 90225836
Hepatic enzyme 32.95 16.43 72 391720 5272 90231383
Eosinophil count increased 32.91 16.43 8 391784 13073 90223582
Dental caries 32.83 16.43 5 391787 11392 90225263
Joint ankylosis 32.76 16.43 34 391758 1269 90235386
Concomitant disease aggravated 32.75 16.43 117 391675 11401 90225254
Poor quality sleep 32.73 16.43 35 391757 24658 90211997
Polyuria 32.39 16.43 3 391789 10037 90226618
Mental impairment 32.16 16.43 16 391776 16704 90219951
Pyoderma gangrenosum 32.03 16.43 64 391728 4400 90232255
Product dose omission in error 32.00 16.43 25 391767 20478 90216177
Xerosis 31.98 16.43 36 391756 1475 90235180
Fear of injection 31.88 16.43 95 391697 8420 90228235
Chromaturia 31.75 16.43 22 391770 19165 90217490
Nerve injury 31.70 16.43 5 391787 11101 90225554
Central nervous system lesion 31.59 16.43 6 391786 11640 90225015
Cholecystitis chronic 31.53 16.43 3 391789 9823 90226832
Skin disorder 31.15 16.43 268 391524 36438 90200217
Pulmonary toxicity 31.15 16.43 6 391786 11525 90225130
Gallbladder disorder 31.09 16.43 24 391768 19779 90216876
Pharyngitis streptococcal 30.90 16.43 123 391669 12619 90224036
Hypotonia 30.75 16.43 6 391786 11420 90225235
Renal injury 30.67 16.43 4 391788 10239 90226416
Feeling jittery 30.65 16.43 14 391778 15357 90221298
Acute coronary syndrome 30.57 16.43 5 391787 10808 90225847
Glaucoma 30.31 16.43 27 391765 20728 90215927
Purpura 30.19 16.43 13 391779 14765 90221890
Embolism 30.15 16.43 3 391789 9478 90227177
Osteopenia 30.04 16.43 33 391759 22969 90213686
Increased appetite 29.98 16.43 7 391785 11758 90224897
Hypertensive crisis 29.96 16.43 20 391772 17764 90218891
Eye disorder 29.88 16.43 45 391747 27345 90209310
Tendonitis 29.82 16.43 176 391616 21196 90215459
Amenorrhoea 29.82 16.43 7 391785 11715 90224940
Haemolytic anaemia 29.73 16.43 7 391785 11690 90224965
Encephalitis 29.64 16.43 6 391786 11128 90225527
Photophobia 29.49 16.43 29 391763 21240 90215415
Tenosynovitis 29.42 16.43 133 391659 14434 90222221
Cold sweat 29.39 16.43 12 391780 14069 90222586
Pneumothorax 29.13 16.43 24 391768 19143 90217512
Fluid retention 29.13 16.43 242 391550 87849 90148806
Rash papular 29.10 16.43 27 391765 20328 90216327
Pulmonary thrombosis 28.86 16.43 4 391788 9778 90226877
Muscle tightness 28.79 16.43 11 391781 13428 90223227
Genital ulceration 28.79 16.43 29 391763 1044 90235611
Electrocardiogram abnormal 28.59 16.43 5 391787 10293 90226362
Lung adenocarcinoma stage IV 28.55 16.43 20 391772 430 90236225
Increased tendency to bruise 28.52 16.43 8 391784 11882 90224773
Pregnancy 28.50 16.43 401 391391 61646 90175009
Dysphonia 28.49 16.43 158 391634 62926 90173729
Product preparation error 28.45 16.43 5 391787 10256 90226399
Cutaneous T-cell lymphoma 28.32 16.43 35 391757 1585 90235070
Decubitus ulcer 28.24 16.43 8 391784 11805 90224850
Mental disorder 28.17 16.43 61 391731 32257 90204398
Abnormal dreams 28.09 16.43 7 391785 11250 90225405
Sneezing 27.98 16.43 223 391569 29646 90207009
Vulvovaginal erythema 27.79 16.43 22 391770 573 90236082
Intestinal ischaemia 27.76 16.43 3 391789 8880 90227775
Chronic disease 27.65 16.43 15 391777 200 90236455
Blood calcium increased 27.32 16.43 9 391783 12049 90224606
Pre-eclampsia 27.32 16.43 7 391785 11041 90225614
Foetal growth restriction 27.29 16.43 4 391788 9376 90227279
Enterocolitis 27.22 16.43 6 391786 10484 90226171
Oesophagitis 26.96 16.43 21 391771 17228 90219427
Alanine aminotransferase abnormal 26.78 16.43 67 391725 5359 90231296
Psoriasis area severity index increased 26.66 16.43 14 391778 174 90236481
Mood altered 26.64 16.43 21 391771 17123 90219532
Colitis ischaemic 26.63 16.43 10 391782 12336 90224319
Pollakiuria 26.59 16.43 65 391727 32940 90203715
Anger 26.58 16.43 13 391779 13707 90222948
Dermatitis bullous 26.56 16.43 6 391786 10310 90226345
Ecchymosis 26.55 16.43 10 391782 12313 90224342
Rash macular 26.52 16.43 57 391735 30223 90206432
Device dispensing error 26.45 16.43 14 391778 177 90236478
Multiple sclerosis 26.44 16.43 50 391742 27790 90208865
Gastric ulcer 26.33 16.43 49 391743 27399 90209256
Faeces discoloured 26.32 16.43 32 391760 21288 90215367
Foot fracture 25.96 16.43 47 391745 26559 90210096
Drug hypersensitivity 25.90 16.43 2334 389458 461275 89775380
Drug dose omission by device 25.81 16.43 100 391692 10131 90226524
Dizziness 25.61 16.43 2196 389596 587088 89649567
Multiple allergies 25.56 16.43 17 391775 15129 90221526
Glycosylated haemoglobin increased 25.55 16.43 18 391774 15544 90221111
Therapeutic product ineffective 25.54 16.43 41 391751 2373 90234282
Hyperthyroidism 25.35 16.43 25 391767 18285 90218370
Haemorrhoids 25.32 16.43 48 391744 26654 90210001
Escherichia infection 25.29 16.43 19 391773 15876 90220779
Disease recurrence 25.25 16.43 81 391711 37572 90199083
Pneumonia viral 25.12 16.43 4 391788 8819 90227836
Cushingoid 24.92 16.43 7 391785 10388 90226267
Initial insomnia 24.82 16.43 5 391787 9305 90227350
Gingival bleeding 24.78 16.43 17 391775 14886 90221769
Myositis 24.75 16.43 184 391608 23944 90212711
Breast cancer female 24.73 16.43 17 391775 14869 90221786
Device occlusion 24.72 16.43 5 391787 9277 90227378
Ocular hyperaemia 24.61 16.43 70 391722 33728 90202927
Papulopustular rosacea 24.60 16.43 9 391783 42 90236613
Thinking abnormal 24.48 16.43 10 391782 11722 90224933
Sleep disorder due to general medical condition, hypersomnia type 24.35 16.43 37 391755 2042 90234613
Tooth fracture 24.32 16.43 12 391780 12588 90224067
Large intestine perforation 24.31 16.43 6 391786 9706 90226949
Stress fracture 24.30 16.43 4 391788 8607 90228048
Therapy partial responder 24.25 16.43 36 391756 22007 90214648
Device difficult to use 24.18 16.43 24 391768 17501 90219154
Pain of skin 24.12 16.43 135 391657 15947 90220708
Splenomegaly 23.92 16.43 13 391779 12911 90223744
Diabetes mellitus 23.89 16.43 173 391619 64702 90171953
COVID-19 pneumonia 23.83 16.43 26 391766 18151 90218504
Fear 23.82 16.43 22 391770 16600 90220055
Coordination abnormal 23.72 16.43 166 391626 21190 90215465
Eyelid ptosis 23.67 16.43 5 391787 9001 90227654
Disability 23.66 16.43 275 391517 40470 90196185
Body height decreased 23.64 16.43 11 391781 11938 90224717
Body temperature increased 23.62 16.43 106 391686 44604 90192051
Product temperature excursion issue 23.49 16.43 24 391768 879 90235776
Urine abnormality 23.22 16.43 3 391789 7734 90228921
Vaginal discharge 23.21 16.43 30 391762 19434 90217221
Blood albumin decreased 23.19 16.43 23 391769 16780 90219875
Staphylococcal sepsis 23.10 16.43 6 391786 9377 90227278
Hereditary angioedema 23.03 16.43 6 391786 9359 90227296
Wrong product administered 22.93 16.43 3 391789 7662 90228993
Abdominal tenderness 22.88 16.43 6 391786 9318 90227337
Injection site bruising 22.81 16.43 335 391457 51972 90184683
Bradyphrenia 22.72 16.43 3 391789 7609 90229046
Crying 22.69 16.43 48 391744 25597 90211058
Fatigue 22.55 16.43 4525 387267 1149498 89087157
Emotional disorder 22.52 16.43 19 391773 14978 90221677
Vitreous floaters 22.48 16.43 3 391789 7546 90229109
Oral lichen planus 22.37 16.43 22 391770 769 90235886
Eye haemorrhage 22.37 16.43 8 391784 10172 90226483
Exposure via partner 22.36 16.43 11 391781 118 90236537
Tension headache 22.32 16.43 3 391789 7506 90229149
Eyelid oedema 22.24 16.43 11 391781 11523 90225132
Gout 22.23 16.43 24 391768 16835 90219820
Seborrhoeic dermatitis 22.14 16.43 32 391760 1688 90234967
Gestational diabetes 22.12 16.43 9 391783 10573 90226082
Spinal pain 22.10 16.43 130 391662 15637 90221018
Arteriosclerosis coronary artery 22.06 16.43 7 391785 9596 90227059
Panic attack 21.97 16.43 51 391741 26314 90210341
Product distribution issue 21.81 16.43 49 391743 3656 90232999
Mouth haemorrhage 21.78 16.43 5 391787 8496 90228159
Pleuritic pain 21.70 16.43 9 391783 10452 90226203
Photosensitivity reaction 21.70 16.43 27 391765 17780 90218875
Drug effective for unapproved indication 21.64 16.43 4 391788 7914 90228741
Flank pain 21.53 16.43 31 391761 19191 90217464
Cholecystectomy 21.50 16.43 12 391780 11743 90224912
Escherichia urinary tract infection 21.37 16.43 17 391775 13798 90222857
Cholecystitis acute 21.34 16.43 7 391785 9397 90227258
Pancreatic carcinoma 21.32 16.43 5 391787 8372 90228283
Epstein-Barr virus infection 21.29 16.43 9 391783 10335 90226320
Pelvic pain 21.22 16.43 21 391771 15336 90221319
Blood triglycerides increased 21.20 16.43 17 391775 13744 90222911
Oral lichenoid reaction 21.11 16.43 10 391782 98 90236557
Dysuria 21.06 16.43 93 391699 39308 90197347
Atrioventricular block 21.02 16.43 6 391786 8809 90227846
Lung neoplasm malignant 21.00 16.43 46 391746 24227 90212428
Nocturia 20.98 16.43 9 391783 10246 90226409
Parakeratosis 20.92 16.43 15 391777 335 90236320
Depression 20.90 16.43 1539 390253 299062 89937593
Actinic keratosis 20.86 16.43 44 391748 3144 90233511
Blood uric acid increased 20.83 16.43 4 391788 7700 90228955
Ear pain 20.80 16.43 358 391434 57344 90179311
Bone disorder 20.68 16.43 43 391749 23077 90213578
Infected dermal cyst 20.61 16.43 17 391775 470 90236185
Blood thyroid stimulating hormone increased 20.45 16.43 7 391785 9148 90227507
Skin burning sensation 20.37 16.43 150 391642 19461 90217194
Intestinal perforation 20.34 16.43 18 391774 13863 90222792
Respiratory syncytial virus infection 20.20 16.43 10 391782 10470 90226185
Renal cyst 19.95 16.43 16 391776 12934 90223721
Staphylococcal bacteraemia 19.94 16.43 4 391788 7465 90229190
Gastrointestinal toxicity 19.87 16.43 8 391784 9459 90227196
Eye swelling 19.86 16.43 63 391729 29323 90207332
Skin fissures 19.84 16.43 156 391636 20653 90216002
Respiration abnormal 19.78 16.43 5 391787 7958 90228697
Myasthenia gravis 19.65 16.43 3 391789 6822 90229833
Retinal detachment 19.64 16.43 3 391789 6819 90229836
Overlap syndrome 19.52 16.43 81 391711 8467 90228188
Upper-airway cough syndrome 19.45 16.43 22 391770 15113 90221542
Ovarian cyst 19.33 16.43 28 391764 17290 90219365
Intervertebral disc protrusion 19.31 16.43 57 391735 27139 90209516
Glomerular filtration rate decreased 19.27 16.43 27 391765 16905 90219750
Ankle impingement 19.24 16.43 6 391786 15 90236640
Product complaint 19.19 16.43 18 391774 13482 90223173
Left ventricular failure 19.16 16.43 3 391789 6697 90229958
Rhesus antigen positive 19.07 16.43 10 391782 124 90236531
Skin mass 19.05 16.43 73 391719 7357 90229298
Nail pitting 19.03 16.43 14 391778 326 90236329
Injection site mass 19 16.43 42 391750 22048 90214607
Mood swings 18.95 16.43 38 391754 20664 90215991
Asthenia 18.94 16.43 2019 389773 531732 89704923
Meningoradiculitis 18.86 16.43 10 391782 127 90236528
Nasal congestion 18.68 16.43 251 391541 83163 90153492
Adjacent segment degeneration 18.59 16.43 7 391785 36 90236619
White blood cells urine positive 18.38 16.43 3 391789 6495 90230160
Coronary artery occlusion 18.33 16.43 7 391785 8547 90228108
Limb injury 18.31 16.43 72 391720 31436 90205219
Rash 18.31 16.43 3801 387991 792299 89444356
Meningitis 18.07 16.43 7 391785 8474 90228181
Face oedema 17.95 16.43 47 391745 23271 90213384
Groin infection 17.90 16.43 17 391775 569 90236086
Carotid artery occlusion 17.78 16.43 3 391789 6339 90230316
Upper limb fracture 17.77 16.43 42 391750 21536 90215119
Aortic stenosis 17.76 16.43 3 391789 6333 90230322
Injection site haemorrhage 17.74 16.43 194 391598 28124 90208531
Urine output decreased 17.69 16.43 17 391775 12586 90224069
Congenital anomaly 17.64 16.43 64 391728 6283 90230372
Hypoaesthesia oral 17.63 16.43 25 391767 15575 90221080
Product administration error 17.61 16.43 57 391735 26366 90210289
Deafness neurosensory 17.57 16.43 4 391788 6837 90229818
Congestive cardiomyopathy 17.54 16.43 5 391787 7349 90229306
Post-traumatic stress disorder 17.52 16.43 4 391788 6824 90229831
Blood pressure diastolic increased 17.43 16.43 18 391774 12888 90223767
Ear pruritus 17.43 16.43 4 391788 6799 90229856
Device breakage 17.42 16.43 21 391771 14023 90222632
Blood iron decreased 17.28 16.43 32 391760 17927 90218728
Lung neoplasm 17.18 16.43 4 391788 6731 90229924
Vulval cancer stage III 17.13 16.43 5 391787 9 90236646
Non-cardiac chest pain 17.12 16.43 4 391788 6717 90229938
Nystagmus 17.08 16.43 5 391787 7222 90229433
Ovarian germ cell teratoma benign 17.01 16.43 10 391782 157 90236498
Hysterectomy 17.00 16.43 15 391777 11569 90225086
Oligohydramnios 16.99 16.43 5 391787 7196 90229459
Toothache 16.96 16.43 45 391747 22185 90214470
Hypercapnia 16.96 16.43 4 391788 6673 90229982
Vulvovaginal swelling 16.91 16.43 19 391773 777 90235878
Hydrocephalus 16.83 16.43 3 391789 6091 90230564
Pemphigoid 16.82 16.43 9 391783 9017 90227638
Spinal stenosis 16.81 16.43 31 391761 17393 90219262
Limb discomfort 16.69 16.43 244 391548 37816 90198839
Genital cyst 16.67 16.43 7 391785 50 90236605
Hip deformity 16.62 16.43 12 391780 271 90236384
Colitis 16.56 16.43 208 391584 69734 90166921
Hepatic cyst 16.56 16.43 4 391788 6564 90230091
Hunger 16.54 16.43 4 391788 6559 90230096
Vasculitis 16.52 16.43 47 391745 22646 90214009
Pulmonary haemorrhage 16.45 16.43 7 391785 8006 90228649

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1812.12 15.09 3669 73140 626528 41917998
Psoriasis 1472.11 15.09 977 75832 47627 42496899
Therapeutic product effect incomplete 1146.58 15.09 979 75830 69960 42474566
Skin plaque 1076.02 15.09 403 76406 5460 42539066
Arthralgia 1057.23 15.09 1555 75254 203683 42340843
Psoriatic arthropathy 959.90 15.09 584 76225 24383 42520143
Inappropriate schedule of product administration 862.94 15.09 960 75849 94942 42449584
Device malfunction 817.28 15.09 413 76396 11914 42532612
Incorrect dose administered 790.47 15.09 699 76110 52275 42492251
Skin exfoliation 698.28 15.09 587 76222 40966 42503560
Musculoskeletal stiffness 624.65 15.09 638 76171 57127 42487399
Pain 578.30 15.09 1325 75484 243523 42301003
Pruritus 549.17 15.09 1112 75697 187659 42356867
Accidental exposure to product 438.25 15.09 333 76476 20060 42524466
Acute kidney injury 428.10 15.09 74 76735 367263 42177263
Arthritis 413.98 15.09 442 76367 41623 42502903
Nasopharyngitis 409.83 15.09 622 76187 83374 42461152
Treatment failure 400.68 15.09 528 76281 62096 42482430
Joint swelling 394.88 15.09 547 76262 67475 42477051
Incorrect dose administered by device 393.78 15.09 158 76651 2598 42541928
Skin lesion 380.05 15.09 346 76463 26828 42517698
Device issue 366.32 15.09 254 76555 13255 42531271
Toxicity to various agents 363.11 15.09 11 76798 229125 42315401
Macule 323.40 15.09 126 76683 1909 42542617
Drug interaction 319.17 15.09 50 76759 266949 42277577
Febrile neutropenia 318.24 15.09 3 76806 185700 42358826
Papule 314.03 15.09 170 76639 5656 42538870
Anaemia 267.99 15.09 86 76723 280192 42264334
Erythema 248.28 15.09 582 76227 108211 42436315
Neck pain 241.40 15.09 284 76525 29730 42514796
Ankylosing spondylitis 233.01 15.09 150 76659 6906 42537620
Hypotension 222.65 15.09 93 76716 257538 42286988
Neutropenia 217.43 15.09 47 76762 199384 42345142
Uveitis 216.27 15.09 159 76650 9099 42535427
Therapeutic product effect decreased 205.12 15.09 300 76509 38850 42505676
Thrombocytopenia 203.08 15.09 47 76762 190232 42354294
Therapy interrupted 201.67 15.09 224 76585 22026 42522500
Off label use 200.64 15.09 545 76264 637790 41906736
Pain in extremity 198.88 15.09 660 76149 149944 42394582
Inflammation 187.00 15.09 266 76543 33581 42510945
Inflammatory bowel disease 184.70 15.09 101 76708 3428 42541098
Pain of skin 175.85 15.09 133 76676 7947 42536579
Dactylitis 174.91 15.09 69 76740 1082 42543444
Back pain 167.65 15.09 599 76210 141177 42403349
Product dose omission issue 152.63 15.09 616 76193 153749 42390777
Device defective 152.59 15.09 70 76739 1618 42542908
Arthropathy 152.41 15.09 225 76584 29372 42515154
Decreased immune responsiveness 152.30 15.09 75 76734 2040 42542486
Respiratory failure 146.23 15.09 27 76782 128105 42416421
Pancytopenia 145.19 15.09 20 76789 117723 42426803
Erysipelas 144.51 15.09 107 76702 6189 42538337
Spinal pain 143.98 15.09 110 76699 6672 42537854
Product storage error 140.54 15.09 134 76675 11006 42533520
Influenza 139.90 15.09 331 76478 61844 42482682
Completed suicide 138.37 15.09 9 76800 96456 42448070
Malaise 129.19 15.09 736 76073 211420 42333106
Disease progression 128.61 15.09 49 76760 143607 42400919
Injection site haemorrhage 127.30 15.09 130 76679 11606 42532920
Constipation 127.07 15.09 67 76742 162224 42382302
Hyponatraemia 125.64 15.09 17 76792 101445 42443081
Needle issue 125.63 15.09 113 76696 8614 42535912
Platelet count decreased 124.51 15.09 47 76762 138534 42405992
Nail psoriasis 123.01 15.09 32 76777 109 42544417
Death 122.96 15.09 437 76372 470748 42073778
Confusional state 122.89 15.09 75 76734 167522 42377004
Synovitis 116.42 15.09 142 76667 15425 42529101
Sinusitis 113.20 15.09 258 76551 47034 42497492
Rhabdomyolysis 112.72 15.09 7 76802 78012 42466514
Cellulitis 112.54 15.09 303 76506 61282 42483244
Oropharyngeal pain 111.99 15.09 241 76568 42269 42502257
Illness 109.36 15.09 176 76633 24754 42519772
Rebound psoriasis 108.37 15.09 30 76779 137 42544389
Seborrhoeic keratosis 104.90 15.09 54 76755 1617 42542909
Therapeutic response shortened 103.58 15.09 125 76684 13429 42531097
Dermatitis psoriasiform 103.55 15.09 58 76751 2064 42542462
Hyperkalaemia 103.21 15.09 12 76797 80446 42464080
Decreased appetite 102.76 15.09 118 76691 193019 42351507
Scab 102.64 15.09 85 76724 5793 42538733
Product prescribing error 102.01 15.09 175 76634 25937 42518589
Cardiac arrest 99.99 15.09 36 76773 109284 42435242
Bradycardia 99.71 15.09 17 76792 85467 42459059
Multiple organ dysfunction syndrome 99.46 15.09 26 76783 97009 42447517
Overdose 99.14 15.09 33 76776 105231 42439295
Peripheral swelling 97.83 15.09 371 76438 89899 42454627
Dehydration 95.08 15.09 70 76739 141697 42402829
C-reactive protein increased 95.07 15.09 291 76518 63269 42481257
Joint stiffness 94.75 15.09 114 76695 12208 42532318
Enthesopathy 93.14 15.09 74 76735 4754 42539772
Vomiting 93.01 15.09 244 76565 289479 42255047
White blood cell count decreased 90.24 15.09 43 76766 110353 42434173
Sepsis 88.57 15.09 139 76670 199195 42345331
COVID-19 87.43 15.09 427 76382 115521 42429005
Seizure 86.88 15.09 55 76754 120506 42424020
Haemoglobin decreased 86.79 15.09 67 76742 132404 42412122
Septic shock 85.87 15.09 29 76780 91643 42452883
Hypoxia 85.65 15.09 12 76797 69774 42474752
Renal failure 85.23 15.09 80 76729 143646 42400880
Lower respiratory tract infection 84.78 15.09 212 76597 40994 42503532
Infection 83.27 15.09 411 76398 111657 42432869
Pelvic pain 83.10 15.09 59 76750 3195 42541331
Neutrophil count decreased 82.48 15.09 9 76800 63406 42481120
Pleural effusion 82.28 15.09 36 76773 97130 42447396
Wrong technique in device usage process 82.22 15.09 55 76754 2702 42541824
Intentional product use issue 82.21 15.09 15 76794 71818 42472708
Hidradenitis 80.67 15.09 46 76763 1695 42542831
Vein rupture 80.43 15.09 38 76771 941 42543585
Sacroiliitis 80.30 15.09 48 76761 1934 42542592
Tachycardia 80.16 15.09 41 76768 101046 42443480
Hypokalaemia 79.91 15.09 16 76793 71705 42472821
Lentigo 79.85 15.09 36 76773 798 42543728
Musculoskeletal discomfort 78.37 15.09 91 76718 9385 42535141
Oral candidiasis 77.75 15.09 112 76697 14293 42530233
Device leakage 77.19 15.09 94 76715 10191 42534335
Localised infection 76.26 15.09 134 76675 20239 42524287
Skin disorder 76.20 15.09 121 76688 16823 42527703
Guttate psoriasis 75.87 15.09 31 76778 535 42543991
Burning sensation 75.81 15.09 136 76673 20877 42523649
Infusion related reaction 75.70 15.09 10 76799 60796 42483730
Cardio-respiratory arrest 74.56 15.09 9 76800 58627 42485899
Neuropathy peripheral 74.02 15.09 46 76763 101807 42442719
Drug intolerance 73.88 15.09 314 76495 80110 42464416
International normalised ratio increased 73.76 15.09 3 76806 48165 42496361
Skin fissures 73.54 15.09 89 76720 9587 42534939
Terminal insomnia 73.44 15.09 35 76774 884 42543642
Depressed level of consciousness 73.41 15.09 3 76806 47967 42496559
Post inflammatory pigmentation change 73.03 15.09 29 76780 463 42544063
Therapeutic product ineffective 72.49 15.09 37 76772 1088 42543438
Therapy cessation 72.05 15.09 131 76678 20319 42524207
Somnolence 72.03 15.09 89 76720 141016 42403510
Mobility decreased 71.95 15.09 181 76628 35125 42509401
Dyspnoea 71.50 15.09 486 76323 442135 42102391
Melanocytic naevus 71.26 15.09 52 76757 2940 42541586
Acne 70.61 15.09 104 76705 13540 42530986
Rash 70.60 15.09 786 76023 276168 42268358
Rash erythematous 69.07 15.09 168 76641 31923 42512603
Metabolic acidosis 68.36 15.09 7 76802 51851 42492675
Epistaxis 68.29 15.09 18 76791 66808 42477718
Delirium 66.93 15.09 8 76801 52511 42492015
Joint ankylosis 66.35 15.09 40 76769 1637 42542889
Concomitant disease aggravated 66.11 15.09 70 76739 6516 42538010
Skin haemorrhage 65.67 15.09 76 76733 7809 42536717
Hypoglycaemia 65.34 15.09 14 76795 59840 42484686
Oxygen saturation decreased 65.01 15.09 18 76791 64669 42479857
Intentional product misuse 64.54 15.09 16 76793 61884 42482642
Gastrointestinal haemorrhage 64.53 15.09 49 76760 97677 42446849
Electrocardiogram QT prolonged 64.44 15.09 6 76803 47939 42496587
Latent tuberculosis 64.04 15.09 39 76770 1626 42542900
Hallucination 63.70 15.09 13 76796 57494 42487032
Pulmonary embolism 63.65 15.09 73 76736 119539 42424987
Device delivery system issue 63.63 15.09 33 76776 1004 42543522
Skin irritation 63.08 15.09 73 76736 7501 42537025
Upper respiratory tract infection 62.96 15.09 193 76616 41980 42502546
Palmoplantar pustulosis 62.58 15.09 26 76783 469 42544057
Injection site pain 62.12 15.09 237 76572 57561 42486965
Coma 61.67 15.09 11 76798 53543 42490983
Plasma cell myeloma 61.24 15.09 7 76802 47571 42496955
Fibromyalgia 60.97 15.09 53 76756 3860 42540666
Drug reaction with eosinophilia and systemic symptoms 60.09 15.09 4 76805 42071 42502455
Tenderness 59.98 15.09 77 76732 8806 42535720
Venous injury 59.66 15.09 23 76786 338 42544188
Agitation 59.09 15.09 21 76788 64293 42480233
Suicide attempt 58.80 15.09 7 76802 46093 42498433
Nail pitting 58.74 15.09 24 76785 414 42544112
Ear infection 58.35 15.09 92 76717 12712 42531814
Movement disorder 58.05 15.09 99 76710 14599 42529927
Lactic acidosis 57.41 15.09 7 76802 45254 42499272
Mucosal inflammation 57.16 15.09 10 76799 49364 42495162
Therapeutic product effect delayed 56.81 15.09 35 76774 1490 42543036
Discomfort 56.39 15.09 134 76675 25085 42519441
Colitis ulcerative 55.23 15.09 136 76673 26039 42518487
Skin infection 55.17 15.09 76 76733 9304 42535222
Lipoma 55.14 15.09 39 76770 2099 42542427
Symptom recurrence 55.01 15.09 34 76775 1456 42543070
Product supply issue 54.65 15.09 34 76775 1473 42543053
Tuberculosis 53.74 15.09 78 76731 10021 42534505
Fall 53.55 15.09 229 76580 234291 42310235
Oral herpes 53.48 15.09 67 76742 7477 42537049
Dry skin 53.42 15.09 200 76609 48138 42496388
Blood creatine phosphokinase increased 53.39 15.09 11 76798 48327 42496199
Scratch 52.96 15.09 56 76753 5205 42539321
Tremor 52.82 15.09 58 76751 96871 42447655
Swelling 51.71 15.09 216 76593 54669 42489857
Atrial fibrillation 51.54 15.09 109 76700 139484 42405042
Drug dose omission by device 51.16 15.09 58 76751 5828 42538698
Pneumonia 50.93 15.09 501 76308 421648 42122878
Onycholysis 50.49 15.09 28 76781 977 42543549
Undifferentiated connective tissue disease 50.37 15.09 15 76794 93 42544433
Musculoskeletal pain 50.15 15.09 153 76656 33187 42511339
Mental status changes 49.93 15.09 8 76801 42107 42502419
Respiratory distress 49.45 15.09 8 76801 41812 42502714
Mycobacterium tuberculosis complex test positive 49.10 15.09 32 76777 1504 42543022
Rhinorrhoea 48.85 15.09 147 76662 31647 42512879
Product distribution issue 48.27 15.09 35 76774 1959 42542567
Seronegative arthritis 47.92 15.09 29 76780 1195 42543331
Skin injury 47.80 15.09 39 76770 2602 42541924
Hyperglycaemia 47.52 15.09 12 76797 45847 42498679
Injection site bruising 47.33 15.09 79 76730 11446 42533080
Syncope 47.32 15.09 66 76743 99340 42445186
Oedema peripheral 47.16 15.09 110 76699 135966 42408560
Renal impairment 46.90 15.09 79 76730 110149 42434377
Pneumonia aspiration 46.60 15.09 16 76793 50062 42494464
Hepatic cirrhosis 46.58 15.09 107 76702 19595 42524931
Encephalopathy 46.50 15.09 9 76800 41324 42503202
Osteoarthritis 46.49 15.09 122 76687 24283 42520243
Pulmonary oedema 46.26 15.09 19 76790 53253 42491273
Ligament calcification 45.78 15.09 17 76792 224 42544302
Dyshidrotic eczema 45.61 15.09 16 76793 177 42544349
Injection site papule 45.56 15.09 19 76790 346 42544180
Actinic keratosis 44.98 15.09 51 76758 5125 42539401
Asthenia 44.87 15.09 309 76500 280484 42264042
Dermatitis 44.30 15.09 78 76731 11797 42532729
Cardiac failure 44.16 15.09 78 76731 106778 42437748
Blood creatinine increased 43.94 15.09 82 76727 109921 42434605
Device deployment issue 43.54 15.09 22 76787 633 42543893
Agranulocytosis 43.45 15.09 3 76806 30609 42513917
Inflammatory pain 43.23 15.09 21 76788 554 42543972
Thymoma benign 43.13 15.09 12 76797 56 42544470
Deep vein thrombosis 43.09 15.09 45 76764 76912 42467614
Grip strength decreased 43.06 15.09 42 76767 3546 42540980
Hypocalcaemia 42.70 15.09 3 76806 30170 42514356
Pharyngitis streptococcal 41.92 15.09 43 76766 3857 42540669
Xerosis 41.90 15.09 24 76785 892 42543634
Alanine aminotransferase abnormal 41.76 15.09 48 76761 4896 42539630
Loss of consciousness 41.34 15.09 64 76745 92290 42452236
Injection site reaction 41.23 15.09 89 76720 15632 42528894
Muscle swelling 41.18 15.09 19 76790 445 42544081
Ascites 40.60 15.09 26 76783 56652 42487874
Bursitis 40.40 15.09 53 76756 6191 42538335
Hypersensitivity 39.98 15.09 245 76564 72125 42472401
Skin papilloma 39.86 15.09 36 76773 2758 42541768
Spinal disorder 39.49 15.09 45 76764 4546 42539980
Product leakage 39.35 15.09 22 76787 780 42543746
Hepatic function abnormal 39.27 15.09 22 76787 51545 42492981
Product dispensing error 39.20 15.09 58 76751 7581 42536945
Injection site warmth 39.12 15.09 35 76774 2648 42541878
Incorrect route of product administration 38.88 15.09 114 76695 24191 42520335
Kidney infection 38.54 15.09 54 76755 6716 42537810
Altered state of consciousness 38.43 15.09 4 76805 29255 42515271
Axial spondyloarthritis 38.27 15.09 19 76790 526 42544000
Drug dependence 38.15 15.09 4 76805 29090 42515436
Aggression 37.95 15.09 16 76793 44147 42500379
Neoplasm skin 37.90 15.09 24 76785 1073 42543453
Self-consciousness 37.71 15.09 13 76796 136 42544390
Skin hyperpigmentation 37.71 15.09 42 76767 4139 42540387
Pneumonitis 37.67 15.09 14 76795 41704 42502822
Cholestasis 37.32 15.09 7 76802 32872 42511654
Abscess limb 36.68 15.09 41 76768 4056 42540470
Ear infection fungal 36.51 15.09 9 76800 23 42544503
Cytomegalovirus infection 36.41 15.09 7 76802 32299 42512227
Abnormal behaviour 36.38 15.09 3 76806 26448 42518078
Medication error 35.68 15.09 8 76801 33146 42511380
Diverticulitis intestinal perforated 35.58 15.09 15 76794 281 42544245
Pustular psoriasis 35.54 15.09 30 76779 2099 42542427
Pyoderma gangrenosum 35.50 15.09 29 76780 1938 42542588
Skin lesion inflammation 34.74 15.09 10 76799 54 42544472
Device dispensing error 34.74 15.09 11 76798 86 42544440
Hepatic steatosis 34.69 15.09 101 76708 21347 42523179
Influenza like illness 34.56 15.09 131 76678 31709 42512817
Spondylitis 34.53 15.09 26 76783 1542 42542984
Blood pressure fluctuation 34.52 15.09 4 76805 26904 42517622
Skin burning sensation 34.39 15.09 54 76755 7433 42537093
Pigmentation disorder 34.37 15.09 35 76774 3113 42541413
Hand deformity 34.24 15.09 38 76771 3730 42540796
Dermatitis exfoliative generalised 33.97 15.09 47 76762 5777 42538749
Cutaneous symptom 33.83 15.09 16 76793 397 42544129
Orthostatic hypotension 33.67 15.09 7 76802 30563 42513963
Psychotic disorder 33.62 15.09 6 76803 29202 42515324
Nail dystrophy 33.50 15.09 16 76793 406 42544120
Shock 33.48 15.09 6 76803 29115 42515411
Tinea versicolour 33.43 15.09 17 76792 496 42544030
Melaena 33.35 15.09 14 76795 38732 42505794
Bone cyst 33.34 15.09 26 76783 1625 42542901
Oligoarthritis 33.18 15.09 13 76796 200 42544326
Lichenification 33.09 15.09 17 76792 507 42544019
Ventricular tachycardia 33.02 15.09 7 76802 30153 42514373
Dysstasia 32.74 15.09 76 76733 14010 42530516
Feeling abnormal 32.30 15.09 226 76583 69560 42474966
Anti-cyclic citrullinated peptide antibody positive 32.04 15.09 27 76782 1885 42542641
Acute respiratory failure 31.93 15.09 15 76794 38843 42505683
Drug resistance 31.76 15.09 11 76798 34237 42510289
Pustule 31.55 15.09 22 76787 1157 42543369
Skin discolouration 31.54 15.09 96 76713 20794 42523732
Tubulointerstitial nephritis 31.28 15.09 9 76800 31539 42512987
Haemorrhage 31.08 15.09 38 76771 60525 42484001
Spinal osteoarthritis 31.05 15.09 56 76753 8630 42535896
Obstructive airways disorder 30.98 15.09 4 76805 24755 42519771
Cyst 30.96 15.09 43 76766 5303 42539223
Hypervolaemia 30.79 15.09 3 76806 23122 42521404
Cough 30.75 15.09 471 76338 177632 42366894
Genital candidiasis 30.44 15.09 10 76799 89 42544437
Tinea pedis 30.42 15.09 27 76782 2021 42542505
Tinea cruris 30.31 15.09 16 76793 505 42544021
Body surface area increased 30.25 15.09 10 76799 91 42544435
Basal cell carcinoma 30.23 15.09 100 76709 22633 42521893
Chronic obstructive pulmonary disease 29.93 15.09 42 76767 63072 42481454
Eosinophilia 29.77 15.09 11 76798 32888 42511638
Aspartate aminotransferase increased 29.52 15.09 59 76750 77104 42467422
Sensitisation 29.48 15.09 13 76796 273 42544253
Urinary retention 29.38 15.09 20 76789 42194 42502332
Hepatocellular injury 29.21 15.09 4 76805 23674 42520852
Stevens-Johnson syndrome 29.21 15.09 3 76806 22175 42522351
Interstitial lung disease 29.16 15.09 61 76748 78401 42466125
Respiratory tract infection 29.15 15.09 109 76700 26213 42518313
Cerebral haemorrhage 29.13 15.09 17 76792 38949 42505577
Nightmare 29.09 15.09 5 76804 25007 42519519
Cutaneous B-cell lymphoma 28.69 15.09 9 76800 68 42544458
Red blood cell sedimentation rate abnormal 28.69 15.09 35 76774 3801 42540725
Tooth abscess 28.61 15.09 47 76762 6721 42537805
Ocular hyperaemia 28.59 15.09 78 76731 15885 42528641
Erythrodermic psoriasis 28.45 15.09 20 76789 1066 42543460
Hyperkeratosis 28.43 15.09 38 76771 4520 42540006
Carbon dioxide abnormal 28.35 15.09 13 76796 300 42544226
Hospitalisation 28.29 15.09 57 76752 74273 42470253
Folliculitis 28.23 15.09 42 76767 5516 42539010
Malignant melanoma 27.91 15.09 56 76753 9344 42535182
Hepatic cytolysis 27.86 15.09 7 76802 26837 42517689
Cutaneous lymphoma 27.85 15.09 10 76799 119 42544407
Haematemesis 27.49 15.09 10 76799 30189 42514337
Product availability issue 27.42 15.09 33 76776 3534 42540992
Gastrointestinal infection 27.39 15.09 46 76763 6697 42537829
Psoriasis area severity index increased 27.31 15.09 9 76800 81 42544445
Generalised tonic-clonic seizure 27.14 15.09 7 76802 26372 42518154
Red blood cell sedimentation rate increased 26.97 15.09 57 76752 9867 42534659
Immune system disorder 26.95 15.09 43 76766 6001 42538525
Dysgeusia 26.88 15.09 14 76795 34175 42510351
Haematuria 26.88 15.09 39 76770 57760 42486766
Tonsillitis 26.84 15.09 29 76780 2762 42541764
Coagulopathy 26.74 15.09 4 76805 22158 42522368
Eye infection 26.65 15.09 36 76773 4325 42540201
Stomatitis 26.44 15.09 31 76778 50298 42494228
Haemangioma of skin 26.20 15.09 11 76798 204 42544322
Hypophagia 26.16 15.09 8 76801 26948 42517578
Premature baby 26.13 15.09 5 76804 23148 42521378
C-reactive protein abnormal 26.11 15.09 54 76755 9207 42535319
Subdural haematoma 26.10 15.09 5 76804 23133 42521393
Restlessness 26.10 15.09 10 76799 29239 42515287
Chronic kidney disease 26.02 15.09 28 76781 47213 42497313
Discharge 25.88 15.09 15 76794 570 42543956
Chronic coronary syndrome 25.70 15.09 12 76797 289 42544237
Nail disorder 25.64 15.09 26 76783 2301 42542225
Dyskinesia 25.62 15.09 7 76802 25383 42519143
Angiocardiogram 25.48 15.09 11 76798 219 42544307
Tooth infection 25.32 15.09 49 76760 7962 42536564
Stress 25.25 15.09 151 76658 44061 42500465
Wound 25.22 15.09 78 76731 17039 42527487
Dizziness 25.10 15.09 308 76501 248946 42295580
Anaphylactic reaction 25.06 15.09 24 76785 42719 42501807
Xyphoid retraction 24.99 15.09 10 76799 163 42544363
Iridocyclitis 24.90 15.09 25 76784 2186 42542340
Body mass index abnormal 24.88 15.09 10 76799 165 42544361
Dandruff 24.83 15.09 12 76797 313 42544213
Tendonitis 24.79 15.09 55 76754 9839 42534687
Nausea 24.78 15.09 536 76273 396263 42148263
Pulmonary hypertension 24.74 15.09 6 76803 23563 42520963
Acute myeloid leukaemia 24.71 15.09 5 76804 22251 42522275
Pneumothorax 24.70 15.09 6 76803 23537 42520989
Anaphylactic shock 24.66 15.09 6 76803 23511 42521015
Bronchopulmonary aspergillosis 24.65 15.09 3 76806 19426 42525100
Accident 24.62 15.09 43 76766 6460 42538066
Atelectasis 24.54 15.09 3 76806 19358 42525168
Secretion discharge 24.50 15.09 47 76762 7588 42536938
Blood bilirubin increased 24.45 15.09 24 76785 42228 42502298
Disorientation 24.32 15.09 18 76791 36371 42508155
Meniscus injury 24.26 15.09 26 76783 2453 42542073
Acute respiratory distress syndrome 24.16 15.09 12 76797 30096 42514430
Troponin increased 24.04 15.09 3 76806 19059 42525467
Gait disturbance 23.90 15.09 276 76533 97724 42446802
Adrenal insufficiency 23.82 15.09 3 76806 18921 42525605
Tachypnoea 23.77 15.09 5 76804 21657 42522869
Insurance issue 23.68 15.09 33 76776 4083 42540443
Clonal haematopoiesis 23.64 15.09 10 76799 189 42544337
Tonsillitis bacterial 23.56 15.09 7 76802 43 42544483
Iritis 23.55 15.09 22 76787 1760 42542766
Marginal zone lymphoma 23.55 15.09 9 76800 129 42544397
Disability 23.47 15.09 40 76769 5893 42538633
Treatment noncompliance 23.46 15.09 20 76789 37652 42506874
Bone erosion 23.41 15.09 34 76775 4369 42540157
Exposure to communicable disease 23.40 15.09 10 76799 194 42544332
Sebaceous hyperplasia 23.30 15.09 9 76800 133 42544393
Rash maculo-papular 23.25 15.09 20 76789 37483 42507043
Irritable bowel syndrome 23.24 15.09 35 76774 4646 42539880
Nephrolithiasis 23.12 15.09 129 76680 36701 42507825
Leukopenia 23.11 15.09 64 76745 74682 42469844
Hepatic failure 22.80 15.09 21 76788 38079 42506447
Haemoptysis 22.62 15.09 30 76779 46137 42498389
Nasal turbinate abnormality 22.54 15.09 7 76802 51 42544475
Skin mass 22.49 15.09 35 76774 4781 42539745
Limb discomfort 22.48 15.09 62 76747 12705 42531821
Full blood count abnormal 22.38 15.09 13 76796 29863 42514663
Rosacea 22.27 15.09 19 76790 1349 42543177
Dyspnoea exertional 22.19 15.09 35 76774 50113 42494413
Sinus tachycardia 22.19 15.09 5 76804 20648 42523878
Full blood count decreased 22.04 15.09 5 76804 20555 42523971
Injection site mass 21.86 15.09 48 76761 8527 42535999
Blood potassium decreased 21.77 15.09 5 76804 20379 42524147
Skin hypertrophy 21.76 15.09 26 76783 2763 42541763
Intestinal haemorrhage 21.73 15.09 31 76778 3920 42540606
Lymphopenia 21.66 15.09 6 76803 21557 42522969
Upper gastrointestinal haemorrhage 21.56 15.09 14 76795 30285 42514241
Intestinal obstruction 21.53 15.09 11 76798 27147 42517379
Flushing 21.46 15.09 21 76788 37007 42507519
General physical health deterioration 21.45 15.09 172 76637 151074 42393452
Hypothyroidism 21.28 15.09 16 76793 32068 42512458
Conjunctivitis viral 21.14 15.09 7 76802 64 42544462
Diabetic ketoacidosis 21.06 15.09 7 76802 22360 42522166
Oesophageal infection 21.05 15.09 11 76798 340 42544186
Inflammatory marker increased 20.96 15.09 41 76768 6715 42537811
Energy increased 20.90 15.09 19 76790 1468 42543058
Prostate cancer 20.90 15.09 145 76664 44498 42500028
Wheezing 20.85 15.09 42 76767 54739 42489787
Hepatic fibrosis 20.82 15.09 34 76775 4838 42539688
Cholesteatoma 20.77 15.09 7 76802 68 42544458
Bronchitis 20.75 15.09 151 76658 47050 42497476
Diarrhoea haemorrhagic 20.63 15.09 44 76765 7663 42536863
Dry mouth 20.48 15.09 25 76784 39854 42504672
Angioimmunoblastic T-cell lymphoma 20.42 15.09 11 76798 362 42544164
Skin discomfort 20.32 15.09 14 76795 722 42543804
Candida infection 20.30 15.09 85 76724 21525 42523001
Bronchiectasis 20.10 15.09 4 76805 18015 42526511
Blood lactate dehydrogenase increased 20.04 15.09 11 76798 26070 42518456
Arrhythmia 19.95 15.09 26 76783 40291 42504235
Subcutaneous abscess 19.89 15.09 32 76777 4496 42540030
Pseudarthrosis 19.83 15.09 7 76802 79 42544447
Lower respiratory tract congestion 19.71 15.09 19 76790 1581 42542945
Disturbance in attention 19.67 15.09 15 76794 29851 42514675
Adverse event 19.62 15.09 9 76800 23631 42520895
Hypokinesia 19.47 15.09 50 76759 9821 42534705
Blood creatinine abnormal 19.38 15.09 26 76783 3103 42541423
Seborrhoeic dermatitis 19.34 15.09 21 76788 2011 42542515
Neurodermatitis 19.30 15.09 14 76795 784 42543742
Ataxia 19.25 15.09 3 76806 16122 42528404
Eczema 19.19 15.09 116 76693 33970 42510556
Accident at work 19.12 15.09 15 76794 946 42543580
Axillary pain 18.91 15.09 11 76798 421 42544105
Syndesmophyte 18.86 15.09 9 76800 228 42544298
Tonsillar disorder 18.82 15.09 11 76798 425 42544101
Pneumocystis jirovecii pneumonia 18.80 15.09 11 76798 25170 42519356
Asthma 18.78 15.09 54 76755 62260 42482266
Feeling hot 18.76 15.09 88 76721 23394 42521132
Oral pustule 18.61 15.09 9 76800 235 42544291
Small intestinal obstruction 18.59 15.09 4 76805 17057 42527469
Intestinal polyp 18.57 15.09 17 76792 1325 42543201
Blood urea increased 18.55 15.09 19 76790 32774 42511752
Hepatic mass 18.28 15.09 16 76793 1176 42543350
Plantar fasciitis 18.24 15.09 25 76784 3045 42541481
Skin swelling 18.19 15.09 24 76785 2818 42541708
Cardiomyopathy 18.11 15.09 6 76803 19204 42525322
Ileus 18.00 15.09 6 76803 19133 42525393
Nail discolouration 17.88 15.09 16 76793 1211 42543315
End stage renal disease 17.81 15.09 4 76805 16554 42527972
Bone marrow failure 17.80 15.09 20 76789 33073 42511453
Therapeutic response decreased 17.79 15.09 121 76688 36891 42507635
Terminal ileitis 17.78 15.09 12 76797 598 42543928
Clostridium difficile colitis 17.78 15.09 8 76801 21244 42523282
Paternal exposure during pregnancy 17.61 15.09 7 76802 112 42544414
Underdose 17.61 15.09 68 76741 16598 42527928
Acrochordon 17.59 15.09 11 76798 481 42544045
Granuloma annulare 17.51 15.09 8 76801 183 42544343
Shock haemorrhagic 17.31 15.09 4 76805 16238 42528288
Haematoma 17.30 15.09 15 76794 28008 42516518
Bacteraemia 17.24 15.09 12 76797 25028 42519498
Hallucination, auditory 17.22 15.09 3 76806 14861 42529665
Unevaluable event 17.08 15.09 22 76787 34266 42510260
Androgenetic alopecia 17.07 15.09 5 76804 29 42544497
Total cholesterol/HDL ratio decreased 17.05 15.09 6 76803 67 42544459
Ear neoplasm 17.05 15.09 6 76803 67 42544459
Lymphocyte count decreased 17.03 15.09 15 76794 27794 42516732
Pancreatic steatosis 16.97 15.09 8 76801 197 42544329
Nasal turbinate hypertrophy 16.90 15.09 8 76801 199 42544327
Contraindicated product administered 16.86 15.09 90 76719 25182 42519344
Osteolysis 16.69 15.09 26 76783 3554 42540972
Adenocarcinoma of colon 16.64 15.09 27 76782 3820 42540706
Heart rate decreased 16.64 15.09 25 76784 36507 42508019
Abdominal discomfort 16.61 15.09 208 76601 75047 42469479
Gastrointestinal pain 16.47 15.09 29 76780 4386 42540140
Nasal congestion 16.36 15.09 100 76709 29401 42515125
Joint effusion 16.17 15.09 34 76775 5863 42538663
Thrombosis 16.15 15.09 66 76743 68445 42476081
Onychomadesis 16.14 15.09 12 76797 698 42543828
Stasis dermatitis 16.02 15.09 15 76794 1203 42543323
Bone marrow oedema 15.98 15.09 13 76796 864 42543662
Psoriasis area severity index decreased 15.96 15.09 3 76806 0 42544526
Leukocytosis 15.93 15.09 18 76791 29690 42514836
Acne conglobata 15.91 15.09 5 76804 38 42544488
Staphylococcal skin infection 15.90 15.09 14 76795 1037 42543489
Lung infiltration 15.83 15.09 3 76806 13986 42530540
Furuncle 15.79 15.09 26 76783 3724 42540802
Scrotal cancer 15.76 15.09 4 76805 12 42544514
Hepatic encephalopathy 15.74 15.09 5 76804 16437 42528089
Viral infection 15.64 15.09 81 76728 22402 42522124
Cutaneous sarcoidosis 15.45 15.09 7 76802 157 42544369
Photodermatosis 15.42 15.09 12 76797 748 42543778
Coronavirus infection 15.40 15.09 31 76778 5183 42539343
Otorrhoea 15.33 15.09 12 76797 754 42543772
Subcorneal pustular dermatosis 15.29 15.09 4 76805 14 42544512
Myositis 15.19 15.09 4 76805 14862 42529664
Irritability 15.13 15.09 17 76792 28111 42516415

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 1757.14 16.86 91 370509 635339 109583360
Toxicity to various agents 1493.10 16.86 23 370577 480532 109738167
Drug interaction 1362.37 16.86 78 370522 500105 109718594
Anaemia 1248.64 16.86 176 370424 546910 109671789
Musculoskeletal stiffness 1246.31 16.86 2837 367763 276985 109941714
Fibromyalgia 1132.11 16.86 2044 368556 168865 110049834
Hypotension 1096.45 16.86 213 370387 523636 109695063
Folliculitis 1084.99 16.86 1985 368615 165668 110053031
Rheumatic fever 1078.12 16.86 1665 368935 120914 110097785
Type 2 diabetes mellitus 1067.82 16.86 2035 368565 175197 110043502
Synovitis 1049.69 16.86 2621 367979 271471 109947228
Psoriasis 1039.75 16.86 1761 368839 138232 110080467
Glossodynia 1034.13 16.86 2292 368308 219712 109998987
Lip dry 1026.08 16.86 1461 369139 98622 110120077
Neutropenia 1021.01 16.86 58 370542 374562 109844137
Wound 1019.31 16.86 2355 368245 232082 109986617
Febrile neutropenia 1015.93 16.86 8 370592 316759 109901940
Hand deformity 1014.53 16.86 2253 368347 216253 110002446
Facet joint syndrome 1014.13 16.86 1428 369172 95400 110123299
Pemphigus 986.72 16.86 2204 368396 212366 110006333
Duodenal ulcer perforation 972.97 16.86 1960 368640 175740 110042959
Helicobacter infection 960.19 16.86 1976 368624 179901 110038798
Systemic lupus erythematosus 944.35 16.86 2404 368196 251934 109966765
Inflammation 912.20 16.86 2006 368594 191232 110027467
Joint range of motion decreased 911.84 16.86 1538 369062 120294 110098405
Mobility decreased 904.23 16.86 2266 368334 235156 109983543
Bursitis 889.85 16.86 1577 369023 128341 110090358
Pericarditis 878.55 16.86 2133 368467 216981 110001718
Irritable bowel syndrome 850.14 16.86 1770 368830 162445 110056254
Anti-cyclic citrullinated peptide antibody positive 849.69 16.86 1881 368719 180103 110038596
Liver injury 836.38 16.86 1670 368930 148743 110069956
Nasopharyngitis 813.00 16.86 3034 367566 391327 109827372
Injury 808.22 16.86 1815 368785 175450 110043249
Rheumatoid arthritis 792.30 16.86 2505 368095 297108 109921591
Muscle injury 788.45 16.86 1568 369032 139239 110079460
Death 782.26 16.86 715 369885 698154 109520545
Wound infection 777.18 16.86 1259 369341 95206 110123493
Joint swelling 774.12 16.86 3235 367365 439610 109779089
Completed suicide 772.85 16.86 7 370593 242374 109976325
Therapy interrupted 772.08 16.86 893 369707 48929 110169770
Peripheral venous disease 763.94 16.86 1160 369440 82957 110135742
Grip strength decreased 754.28 16.86 1124 369476 79050 110139649
Gait inability 753.19 16.86 1510 369090 134866 110083833
Constipation 742.87 16.86 148 370452 357638 109861061
C-reactive protein abnormal 740.29 16.86 1456 369144 128239 110090460
Osteoarthritis 734.25 16.86 1780 368820 180843 110037856
Night sweats 723.83 16.86 1470 369130 132513 110086186
Swollen joint count increased 723.65 16.86 1128 369472 82533 110136166
Rheumatoid factor positive 704.87 16.86 1439 369161 130201 110088498
Blood cholesterol increased 685.88 16.86 1747 368853 183038 110035661
Impaired healing 669.04 16.86 1800 368800 194917 110023782
Breast cancer stage III 666.62 16.86 1054 369546 78063 110140636
Arthropathy 641.08 16.86 2270 368330 285252 109933447
Obesity 640.17 16.86 1267 369333 112084 110106615
Hyponatraemia 631.04 16.86 22 370578 217631 110001068
Blister 628.43 16.86 1931 368669 225445 109993254
Thrombocytopenia 622.62 16.86 197 370403 348688 109870011
Somnolence 579.06 16.86 142 370458 297307 109921392
Lower respiratory tract infection 570.11 16.86 1952 368648 241154 109977545
Platelet count decreased 564.78 16.86 58 370542 230385 109988314
Disease progression 557.24 16.86 78 370522 243956 109974743
Malignant neoplasm progression 556.64 16.86 5 370595 174562 110044137
Respiratory failure 549.59 16.86 46 370554 215286 110003413
Swelling 548.30 16.86 2480 368120 348561 109870138
Sepsis 545.86 16.86 207 370393 327139 109891560
Pancytopenia 545.55 16.86 41 370559 209572 110009127
Dehydration 544.94 16.86 133 370467 279378 109939321
Nail disorder 528.85 16.86 801 369799 57134 110161565
Lower limb fracture 509.73 16.86 910 369690 74438 110144261
Discomfort 509.51 16.86 1731 368869 212976 110005723
Hypercholesterolaemia 500.42 16.86 1005 369595 89832 110128867
Cardiac arrest 499.47 16.86 43 370557 196710 110021989
Hypoaesthesia 494.41 16.86 2225 368375 311998 109906701
Musculoskeletal pain 494.11 16.86 1542 369058 181481 110037218
Dry mouth 493.01 16.86 1633 368967 198315 110020384
Deep vein thrombosis postoperative 492.69 16.86 785 369815 58506 110160193
Haemoglobin decreased 485.52 16.86 118 370482 248609 109970090
Psoriatic arthropathy 482.48 16.86 1604 368996 195157 110023542
Ill-defined disorder 480.58 16.86 1382 369218 155471 110063228
White blood cell count decreased 471.54 16.86 97 370503 229293 109989406
Therapeutic product effect decreased 470.92 16.86 1841 368759 242475 109976224
Hepatic enzyme increased 466.31 16.86 2220 368380 318672 109900027
Arthralgia 462.52 16.86 4307 366293 775325 109443374
Road traffic accident 458.61 16.86 1072 369528 106326 110112373
Alopecia 455.78 16.86 2418 368182 362335 109856364
Sciatica 451.29 16.86 973 369627 91426 110127273
Renal failure 451.11 16.86 103 370497 226471 109992228
Lung disorder 450.58 16.86 1478 369122 178569 110040130
Bradycardia 449.77 16.86 16 370584 155501 110063198
Dislocation of vertebra 448.95 16.86 639 369961 43082 110175617
Seizure 445.49 16.86 98 370502 221087 109997612
Treatment failure 439.71 16.86 1968 368632 275266 109943433
Autoimmune disorder 439.26 16.86 788 369812 64695 110154004
Live birth 438.08 16.86 814 369786 68670 110150029
Wheezing 434.66 16.86 1851 368749 253379 109965320
Pulmonary embolism 432.01 16.86 95 370505 214379 110004320
Gastrointestinal disorder 425.46 16.86 1772 368828 240180 109978519
C-reactive protein increased 419.83 16.86 1642 368958 216277 110002422
Blepharospasm 418.85 16.86 699 369901 54152 110164547
Stomatitis 417.82 16.86 1904 368696 268338 109950361
Cardiac failure 416.68 16.86 65 370535 187561 110031138
Neck pain 413.67 16.86 1122 369478 122008 110096691
Inappropriate schedule of product administration 406.66 16.86 1552 369048 202085 110016614
Skin plaque 406.35 16.86 338 370262 12307 110206392
Multiple organ dysfunction syndrome 402.46 16.86 27 370573 151683 110067016
Onychomadesis 399.38 16.86 619 369981 45044 110173655
Sleep disorder 398.35 16.86 1516 369084 197128 110021571
Abdominal discomfort 397.06 16.86 2466 368134 391392 109827307
Syncope 395.42 16.86 96 370504 202440 110016259
Oxygen saturation decreased 393.84 16.86 36 370564 156946 110061753
Hyperkalaemia 392.59 16.86 14 370586 135782 110082917
Adjustment disorder with depressed mood 386.78 16.86 597 370003 43286 110175413
Maternal exposure during pregnancy 386.73 16.86 1786 368814 253097 109965602
Back injury 376.66 16.86 615 369985 46784 110171915
Atrial fibrillation 374.80 16.86 150 370450 229492 109989207
Urticaria 372.70 16.86 2076 368524 316781 109901918
Gastrointestinal haemorrhage 370.60 16.86 56 370544 165462 110053237
Tremor 369.96 16.86 109 370491 202123 110016576
Intentional overdose 368.58 16.86 18 370582 132483 110086216
Rhabdomyolysis 368.31 16.86 7 370593 120394 110098305
Sleep disorder due to general medical condition, insomnia type 364.25 16.86 972 369628 104671 110114028
Prescribed overdose 363.89 16.86 865 369735 86716 110131983
Dyspnoea 363.67 16.86 2199 368401 1104673 109114026
Sinusitis 361.04 16.86 1953 368647 294735 109923964
Neutrophil count decreased 358.48 16.86 10 370590 120931 110097768
Depressed level of consciousness 354.27 16.86 4 370596 112274 110106425
Hypoxia 352.71 16.86 20 370580 129495 110089204
Neuropathy peripheral 347.97 16.86 86 370514 179191 110039508
Arthritis 347.59 16.86 1293 369307 166293 110052406
Drug intolerance 347.15 16.86 2442 368158 404070 109814629
Retinitis 344.53 16.86 481 370119 31846 110186853
Product label confusion 342.12 16.86 401 370199 22276 110196423
Renal impairment 340.30 16.86 104 370496 188341 110030358
Electrocardiogram QT prolonged 334.66 16.86 6 370594 108954 110109745
Pleural effusion 333.92 16.86 91 370509 177618 110041081
Hypokalaemia 332.52 16.86 99 370501 182349 110036350
Cardio-respiratory arrest 327.86 16.86 14 370586 115822 110102877
Peripheral swelling 324.12 16.86 2391 368209 401643 109817056
Contraindicated product administered 323.75 16.86 1666 368934 246601 109972098
X-ray abnormal 321.24 16.86 508 370092 37609 110181090
Liver function test increased 316.73 16.86 826 369774 87722 110130977
Cardiac failure congestive 316.23 16.86 61 370539 150939 110067760
Coma 315.52 16.86 20 370580 117849 110100850
Infection 309.27 16.86 2176 368424 360024 109858675
Taste disorder 307.22 16.86 678 369922 64709 110153990
C-reactive protein 306.53 16.86 440 370160 29891 110188808
Off label use 305.13 16.86 3390 367210 1496795 108721904
Hypersensitivity 302.24 16.86 2352 368248 401646 109817053
Pain 299.69 16.86 4674 365926 950281 109268418
Myelosuppression 299.31 16.86 3 370597 94337 110124362
Finger deformity 288.55 16.86 448 370152 32644 110186055
Epistaxis 287.55 16.86 46 370554 130326 110088373
Therapeutic product effect incomplete 284.94 16.86 1492 369108 222313 109996386
Metabolic acidosis 282.47 16.86 12 370588 99732 110118967
Hypoglycaemia 279.83 16.86 31 370569 116073 110102626
Hallucination 275.16 16.86 16 370584 101416 110117283
Lupus vulgaris 275.14 16.86 444 370156 33439 110185260
Lactic acidosis 266.77 16.86 10 370590 92801 110125898
Agitation 265.47 16.86 33 370567 113018 110105681
Liver disorder 264.27 16.86 1060 369540 141183 110077516
Hyperglycaemia 264.19 16.86 4 370596 85086 110133613
International normalised ratio increased 261.61 16.86 6 370594 86766 110131933
Interstitial lung disease 260.53 16.86 72 370528 139262 110079437
Migraine 260.34 16.86 1203 369397 170449 110048250
Septic shock 258.46 16.86 102 370498 157426 110061273
Bone erosion 254.05 16.86 512 370088 45859 110172840
Malaise 253.94 16.86 3398 367202 668421 109550278
General physical health deterioration 253.60 16.86 2354 368246 422941 109795758
Ear infection 248.14 16.86 608 369992 62124 110156575
Laryngitis 247.70 16.86 481 370119 41930 110176769
Red blood cell sedimentation rate increased 247.54 16.86 698 369902 77604 110141095
Onychomycosis 246.10 16.86 454 370146 38077 110180622
Suicide attempt 245.69 16.86 29 370571 103365 110115334
Infusion related reaction 239.55 16.86 2134 368466 379028 109839671
Overdose 239.27 16.86 258 370342 233536 109985163
Intentional product misuse 233.42 16.86 77 370523 132827 110085872
Exostosis 232.45 16.86 491 370109 45465 110173234
Pulmonary oedema 232.45 16.86 31 370569 100628 110118071
Fall 231.65 16.86 1137 369463 602345 109616354
Memory impairment 231.04 16.86 1284 369316 195660 110023039
Drug reaction with eosinophilia and systemic symptoms 228.79 16.86 11 370589 82084 110136615
Encephalopathy 228.70 16.86 10 370590 81045 110137654
Loss of consciousness 227.24 16.86 194 370406 196112 110022587
Pulmonary fibrosis 223.03 16.86 801 369799 101241 110117458
Lupus-like syndrome 220.61 16.86 448 370152 40344 110178355
Balance disorder 214.64 16.86 62 370538 116498 110102201
Blood creatinine increased 210.16 16.86 182 370418 182707 110035992
Mental status changes 209.60 16.86 11 370589 76111 110142588
Mucosal inflammation 207.40 16.86 36 370564 96105 110122594
Tachycardia 204.44 16.86 276 370324 226369 109992330
Prescribed underdose 204.07 16.86 579 370021 64595 110154104
Adverse reaction 203.39 16.86 360 370240 29234 110189465
Hepatic function abnormal 202.65 16.86 29 370571 89266 110129433
Enthesopathy 202.27 16.86 229 370371 12249 110206450
Ascites 197.49 16.86 36 370564 92772 110125927
Dyspepsia 196.69 16.86 1203 369397 189762 110028937
Deep vein thrombosis 196.61 16.86 112 370488 139775 110078924
Product quality issue 194.50 16.86 636 369964 76663 110142036
Leukopenia 191.37 16.86 132 370468 148659 110070040
Coeliac disease 190.77 16.86 437 370163 42750 110175949
Pain in extremity 189.69 16.86 2478 368122 484640 109734059
Nausea 188.74 16.86 2961 367639 1232729 108985970
Intentional product use issue 187.78 16.86 1448 369152 246458 109972241
Acute respiratory failure 186.76 16.86 18 370582 75242 110143457
Myocardial infarction 185.61 16.86 222 370378 191861 110026838
Seronegative arthritis 183.95 16.86 224 370376 12953 110205746
Product use issue 183.51 16.86 1721 368879 309974 109908725
Unresponsive to stimuli 182.89 16.86 7 370593 63783 110154916
Cognitive disorder 181.84 16.86 36 370564 87475 110131224
Dyspnoea exertional 181.48 16.86 61 370539 103999 110114700
Orthostatic hypotension 181.07 16.86 10 370590 66239 110152460
Hepatic cirrhosis 178.84 16.86 566 370034 67060 110151639
Cholestasis 178.66 16.86 9 370591 64509 110154190
Blood pressure fluctuation 177.74 16.86 21 370579 74803 110143896
Cardiogenic shock 176.72 16.86 3 370597 57335 110161364
Abdominal pain upper 176.21 16.86 1867 368733 347244 109871455
Pneumonitis 175.68 16.86 24 370576 76507 110142192
Toxic epidermal necrolysis 174.70 16.86 3 370597 56724 110161975
Blood bilirubin increased 173.99 16.86 24 370576 75948 110142751
Epilepsy 173.64 16.86 731 369869 99478 110119221
Blood creatine phosphokinase increased 172.38 16.86 21 370579 73056 110145643
Bone marrow failure 170.62 16.86 5 370595 57843 110160856
Aspartate aminotransferase increased 169.80 16.86 171 370429 159765 110058934
Pneumonia aspiration 169.67 16.86 33 370567 81200 110137499
Respiratory arrest 168.52 16.86 6 370594 58293 110160406
Neoplasm progression 166.96 16.86 13 370587 64582 110154117
Rash maculo-papular 166.36 16.86 25 370575 74197 110144502
Altered state of consciousness 166.33 16.86 6 370594 57620 110161079
Anti-cyclic citrullinated peptide antibody 165.35 16.86 264 370336 19700 110198999
Plasma cell myeloma 164.56 16.86 12 370588 62924 110155775
Thrombosis 164.53 16.86 79 370521 108583 110110116
Inflammatory bowel disease 164.32 16.86 159 370441 7075 110211624
Skin exfoliation 164.20 16.86 655 369945 86996 110131703
Melaena 164.06 16.86 19 370581 68738 110149961
Hyperhidrosis 163.98 16.86 233 370367 187065 110031634
Chronic obstructive pulmonary disease 162.79 16.86 81 370519 109077 110109622
Muscular weakness 162.11 16.86 1403 369197 247065 109971634
Heart rate decreased 159.95 16.86 40 370560 82716 110135983
Urinary retention 159.61 16.86 22 370578 69661 110149038
Blood pressure decreased 157.69 16.86 95 370505 114996 110103703
Blood glucose increased 155.70 16.86 129 370471 132367 110086332
Drug tolerance decreased 153.14 16.86 306 370294 27234 110191465
Cytomegalovirus infection 152.67 16.86 7 370593 54437 110164262
Oedema 152.65 16.86 1215 369385 208761 110009938
Adverse event 152.13 16.86 745 369855 108064 110110635
Foot deformity 152.07 16.86 431 370169 48049 110170650
Flushing 151.31 16.86 81 370519 104655 110114044
Chronic kidney disease 151.13 16.86 35 370565 76256 110142443
Breast cancer stage II 150.82 16.86 303 370297 27072 110191627
Dactylitis 150.81 16.86 119 370481 4014 110214685
Haemorrhage 150.53 16.86 85 370515 106607 110112092
Respiratory distress 150.30 16.86 25 370575 68849 110149850
Generalised tonic-clonic seizure 150.23 16.86 8 370592 54672 110164027
Joint dislocation 149.94 16.86 345 370255 33845 110184854
Hip arthroplasty 149.29 16.86 469 370131 55344 110163355
Disorientation 149.10 16.86 28 370572 70643 110148056
Hypervolaemia 146.89 16.86 4 370596 49456 110169243
Vision blurred 146.27 16.86 130 370470 128892 110089807
Shock 143.68 16.86 9 370591 53579 110165120
Hypomagnesaemia 143.25 16.86 17 370583 60353 110158346
Tubulointerstitial nephritis 142.94 16.86 10 370590 54274 110164425
Joint stiffness 141.97 16.86 522 370078 66721 110151978
Ankylosing spondylitis 141.21 16.86 215 370385 15397 110203302
Muscle spasms 140.97 16.86 1489 369111 276668 109942031
Cerebral haemorrhage 140.84 16.86 24 370576 64944 110153755
Hepatocellular injury 140.43 16.86 7 370593 50635 110168064
Skin haemorrhage 139.42 16.86 277 370323 24550 110194149
Dysgeusia 138.85 16.86 32 370568 69953 110148746
Aggression 137.26 16.86 18 370582 59192 110159507
Maternal exposure timing unspecified 137.22 16.86 250 370350 20763 110197936
Incorrect route of product administration 136.68 16.86 499 370101 63562 110155137
Myalgia 136.29 16.86 343 370257 222038 109996661
Neurologic neglect syndrome 136.24 16.86 162 370438 9136 110209563
Eosinophilia 135.79 16.86 17 370583 57919 110160780
Hypothyroidism 135.64 16.86 38 370562 72861 110145838
Ventricular tachycardia 135.29 16.86 8 370592 50001 110168698
Porphyria acute 134.96 16.86 233 370367 18547 110200152
Pulmonary hypertension 134.95 16.86 14 370586 55206 110163493
Therapy non-responder 134.56 16.86 946 369654 156361 110062338
Psychotic disorder 132.36 16.86 10 370590 50927 110167772
Chills 132.12 16.86 275 370325 190305 110028394
Carotid artery thrombosis 131.56 16.86 162 370438 9476 110209223
Drug resistance 131.02 16.86 17 370583 56357 110162342
Full blood count abnormal 130.04 16.86 17 370583 56035 110162664
Disturbance in attention 129.86 16.86 25 370575 61970 110156729
Hidradenitis 129.38 16.86 120 370480 5060 110213639
Illness 129.04 16.86 582 370018 81589 110137110
Lymphocyte count decreased 128.94 16.86 19 370581 57224 110161475
Heart rate increased 128.82 16.86 176 370424 143658 110075041
Stevens-Johnson syndrome 128.42 16.86 7 370593 46894 110171805
Incorrect dose administered 128.39 16.86 686 369914 102955 110115744
Alanine aminotransferase increased 125.87 16.86 267 370333 183506 110035193
Contusion 125.73 16.86 1265 369335 232096 109986603
Haematemesis 125.60 16.86 23 370577 59085 110159614
Hypophagia 124.43 16.86 15 370585 52611 110166088
Disseminated intravascular coagulation 123.89 16.86 3 370597 41283 110177416
Dyskinesia 123.29 16.86 14 370586 51432 110167267
Pustular psoriasis 122.55 16.86 187 370413 13418 110205281
Weight increased 122.36 16.86 2031 368569 417613 109801086
Skin lesion 122.04 16.86 416 370184 51215 110167484
Blood alkaline phosphatase increased 121.24 16.86 43 370557 70892 110147807
Macule 120.86 16.86 100 370500 3613 110215086
Sinus tachycardia 120.72 16.86 7 370593 44486 110174213
Knee arthroplasty 120.56 16.86 484 370116 64464 110154235
Haematuria 120.19 16.86 64 370536 82941 110135758
Hepatic cytolysis 120.09 16.86 20 370580 55033 110163666
Hallucination, visual 118.38 16.86 3 370597 39602 110179097
Pericardial effusion 117.91 16.86 24 370576 57193 110161506
Device malfunction 117.75 16.86 263 370337 25295 110193404
Jaundice 117.68 16.86 27 370573 59209 110159490
Obstructive airways disorder 117.29 16.86 10 370590 46139 110172560
Hepatic failure 116.92 16.86 42 370558 68697 110150002
Drug ineffective for unapproved indication 116.10 16.86 104 370496 102734 110115965
Pallor 115.71 16.86 24 370576 56443 110162256
Blood potassium decreased 115.11 16.86 21 370579 54093 110164606
Infusion site reaction 114.99 16.86 210 370390 17472 110201227
Cerebral infarction 114.94 16.86 18 370582 51820 110166879
Pancreatitis acute 114.82 16.86 30 370570 60244 110158455
Acute respiratory distress syndrome 114.56 16.86 20 370580 53178 110165521
Upper gastrointestinal haemorrhage 114.30 16.86 16 370584 50080 110168619
Amnesia 113.55 16.86 672 369928 104736 110113963
Blood urea increased 113.36 16.86 23 370577 54934 110163765
Osteonecrosis of jaw 112.76 16.86 14 370586 48003 110170696
Arrhythmia 112.54 16.86 46 370554 69529 110149170
Liver function test abnormal 112.49 16.86 45 370555 68905 110149794
Pruritus 112.05 16.86 2644 367956 578916 109639783
Tinnitus 111.82 16.86 32 370568 60508 110158191
Haematoma 111.59 16.86 29 370571 58447 110160252
Adjustment disorder 111.12 16.86 158 370442 10637 110208062
Leukocytosis 110.05 16.86 23 370577 53805 110164894
Diabetic ketoacidosis 110.02 16.86 8 370592 42050 110176649
Haematocrit decreased 109.76 16.86 42 370558 66075 110152624
Hypocalcaemia 109.39 16.86 41 370559 65325 110153374
Coagulopathy 109.30 16.86 7 370593 40904 110177795
Red blood cell count decreased 109.24 16.86 42 370558 65881 110152818
Abnormal behaviour 106.35 16.86 6 370594 39033 110179666
Multiple sclerosis relapse 105.78 16.86 20 370580 50220 110168479
Influenza 105.65 16.86 946 369654 168155 110050544
Drug dependence 105.13 16.86 20 370580 50000 110168699
Tachypnoea 104.48 16.86 7 370593 39388 110179311
Hypertension 104.42 16.86 2339 368261 507745 109710954
Exposure during pregnancy 104.28 16.86 936 369664 166488 110052211
Presyncope 103.92 16.86 19 370581 48868 110169831
Paraesthesia 103.42 16.86 1397 369203 275124 109943575
Acute myeloid leukaemia 103.38 16.86 6 370594 38104 110180595
Coronary artery disease 102.74 16.86 56 370544 71634 110147065
Intestinal obstruction 102.33 16.86 26 370574 53201 110165498
Adverse drug reaction 101.77 16.86 654 369946 104905 110113794
Blood lactate dehydrogenase increased 101.53 16.86 14 370586 44320 110174379
Subdural haematoma 101.20 16.86 5 370595 36449 110182250
Pregnancy 100.80 16.86 388 370212 50679 110168020
Ulcer haemorrhage 100.35 16.86 229 370371 22342 110196357
Anaphylactic shock 99.45 16.86 25 370575 51521 110167178
Angioedema 99.28 16.86 110 370490 98390 110120309
Accidental overdose 98.35 16.86 26 370574 51808 110166891
Anaphylactic reaction 98.24 16.86 144 370456 114156 110104543
Gastrooesophageal reflux disease 98.07 16.86 978 369622 178998 110039701
Transient ischaemic attack 97.65 16.86 46 370554 63936 110154763
Sacroiliitis 97.57 16.86 101 370499 4877 110213822
Personality disorder 97.17 16.86 163 370437 12674 110206025
Drug ineffective 96.84 16.86 6113 364487 1514427 108704272
Myoclonus 96.78 16.86 3 370597 32995 110185704
Haemoptysis 96.20 16.86 60 370540 71294 110147405
Blood calcium decreased 96.16 16.86 6 370594 35839 110182860
Intentional self-injury 95.43 16.86 8 370592 37421 110181278
Spondylitis 95.37 16.86 151 370449 11187 110207512
Blood pressure increased 94.81 16.86 494 370106 257879 109960820
Electrolyte imbalance 94.17 16.86 8 370592 37020 110181679
Normal newborn 93.88 16.86 219 370381 21677 110197022
Pneumocystis jirovecii pneumonia 92.17 16.86 16 370584 42719 110175980
Status epilepticus 92.12 16.86 3 370597 31568 110187131
Hepatotoxicity 91.62 16.86 49 370551 63351 110155348
Bacteraemia 91.14 16.86 16 370584 42374 110176325
Acute myocardial infarction 90.71 16.86 88 370512 83689 110135010
Brain oedema 90.58 16.86 3 370597 31095 110187604
Atelectasis 90.51 16.86 9 370591 36703 110181996
Myelodysplastic syndrome 90.33 16.86 10 370590 37474 110181225
Sinus congestion 89.93 16.86 265 370335 30194 110188505
Product dose omission issue 89.71 16.86 670 369930 321112 109897587
Clostridium difficile colitis 88.89 16.86 19 370581 43759 110174940
Lethargy 88.41 16.86 110 370490 93466 110125233
Full blood count decreased 87.24 16.86 5 370595 32094 110186605
Insomnia 86.95 16.86 1694 368906 358896 109859803
Lymphopenia 86.72 16.86 15 370585 40155 110178544
Bronchopulmonary aspergillosis 86.57 16.86 3 370597 29860 110188839
Muscle spasticity 85.43 16.86 290 370310 35625 110183074
Sinus bradycardia 85.33 16.86 3 370597 29480 110189219
Restlessness 85.01 16.86 41 370559 56218 110162481
Gamma-glutamyltransferase increased 84.83 16.86 50 370550 61259 110157440
Device related infection 84.78 16.86 15 370585 39504 110179195
Pain in jaw 84.14 16.86 33 370567 51144 110167555
Cardiomyopathy 83.22 16.86 8 370592 33517 110185182
Ileus 82.87 16.86 5 370595 30724 110187975
Nightmare 82.83 16.86 15 370585 38848 110179851
Mitral valve incompetence 82.61 16.86 8 370592 33321 110185378
Haemophagocytic lymphohistiocytosis 82.56 16.86 6 370594 31553 110187146
Bronchiectasis 82.45 16.86 12 370588 36481 110182218
Cytopenia 80.91 16.86 5 370595 30111 110188588
Ataxia 80.89 16.86 5 370595 30103 110188596
Injection site reaction 80.49 16.86 543 370057 88527 110130172
Wrong technique in product usage process 80.11 16.86 105 370495 87243 110131456
Troponin increased 79.80 16.86 5 370595 29761 110188938
Swelling face 79.64 16.86 116 370484 92205 110126494
Subarachnoid haemorrhage 79.59 16.86 5 370595 29697 110189002
Paraesthesia oral 78.62 16.86 10 370590 33661 110185038
Ejection fraction decreased 78.53 16.86 20 370580 40860 110177839
Irritability 78.32 16.86 31 370569 47778 110170921
Arterial occlusive disease 77.92 16.86 164 370436 15144 110203555
Clostridium difficile infection 77.24 16.86 39 370561 52090 110166609
Vertigo 77.07 16.86 107 370493 86763 110131936
Unevaluable event 76.86 16.86 52 370548 59175 110159524
Cyanosis 76.82 16.86 6 370594 29735 110188964
Cholelithiasis 76.68 16.86 60 370540 63362 110155337
Proteinuria 76.07 16.86 20 370580 39998 110178701
Polyneuropathy 75.99 16.86 9 370591 32003 110186696
Diplopia 75.81 16.86 23 370577 41871 110176828
Drug hypersensitivity 75.66 16.86 2025 368575 452065 109766634
Hepatic encephalopathy 75.00 16.86 5 370595 28251 110190448
Shock haemorrhagic 74.81 16.86 4 370596 27243 110191456
Hypoalbuminaemia 74.40 16.86 6 370594 28968 110189731
Acute hepatic failure 73.69 16.86 16 370584 36452 110182247
Haematochezia 73.25 16.86 175 370425 115349 110103350
Walking aid user 72.93 16.86 217 370383 24858 110193841
Incorrect dose administered by device 72.01 16.86 101 370499 6713 110211986
Hypothermia 71.78 16.86 4 370596 26298 110192401
Uveitis 71.02 16.86 196 370404 21514 110197185
Myopathy 70.67 16.86 3 370597 24957 110193742
Respiratory tract congestion 70.63 16.86 246 370354 30611 110188088
Hyperbilirubinaemia 69.49 16.86 10 370590 30661 110188038
Blood sodium decreased 69.40 16.86 21 370579 38298 110180401
Premature delivery 69.38 16.86 10 370590 30622 110188077
Hallucination, auditory 69.10 16.86 5 370595 26392 110192307
Suicidal ideation 68.99 16.86 131 370469 93806 110124893
Renal tubular necrosis 68.90 16.86 10 370590 30465 110188234
Peritonitis 68.61 16.86 13 370587 32594 110186105
Subcutaneous drug absorption impaired 68.60 16.86 105 370495 7554 110211145
Aplastic anaemia 68.56 16.86 3 370597 24305 110194394
Grip strength 67.77 16.86 115 370485 9026 110209673
Myocarditis 67.63 16.86 10 370590 30045 110188654
Spinal pain 67.49 16.86 174 370426 18341 110200358
Circulatory collapse 67.02 16.86 30 370570 42963 110175736
Delusion 66.78 16.86 3 370597 23752 110194947
Nail psoriasis 66.72 16.86 37 370563 677 110218022
Colitis ulcerative 66.56 16.86 466 370134 76897 110141802
Decreased immune responsiveness 66.19 16.86 117 370483 9489 110209210
Left ventricular dysfunction 65.93 16.86 3 370597 23490 110195209
Red blood cell sedimentation rate 65.37 16.86 84 370516 5130 110213569
Rebound psoriasis 65.18 16.86 26 370574 214 110218485
Muscle twitching 65.01 16.86 11 370589 29924 110188775
Hypocholesterolaemia 64.65 16.86 93 370507 6328 110212371
Treatment noncompliance 64.65 16.86 90 370510 72900 110145799
Haemodynamic instability 63.98 16.86 3 370597 22885 110195814
Rales 63.87 16.86 5 370595 24734 110193965
Lung infiltration 63.52 16.86 5 370595 24623 110194076
Supraventricular tachycardia 62.87 16.86 5 370595 24417 110194282
Poisoning 62.54 16.86 11 370589 29094 110189605
Blindness 62.20 16.86 22 370578 36337 110182362
Renal disorder 62.14 16.86 45 370555 49434 110169265
Injection site erythema 61.84 16.86 140 370460 94036 110124663
Cardiac failure acute 61.79 16.86 5 370595 24073 110194626
Malnutrition 61.56 16.86 9 370591 27270 110191429
Aspergillus infection 61.31 16.86 7 370593 25609 110193090
Neuralgia 61.00 16.86 44 370556 48434 110170265
Neutrophil count increased 60.96 16.86 20 370580 34632 110184067
Disability 60.77 16.86 231 370369 29992 110188707
Palmoplantar pustulosis 60.57 16.86 39 370561 947 110217752
Schizophrenia 60.57 16.86 3 370597 21823 110196876
Acute generalised exanthematous pustulosis 60.05 16.86 3 370597 21661 110197038
Chronic sinusitis 59.67 16.86 7 370593 25077 110193622
Small intestinal obstruction 59.54 16.86 17 370583 32196 110186503
Transaminases increased 59.37 16.86 75 370525 63315 110155384
Pharyngitis streptococcal 59.35 16.86 135 370465 13142 110205557
Osteoporosis 59.34 16.86 497 370103 86655 110132044
Femur fracture 59.11 16.86 38 370562 44431 110174268
Generalised oedema 59.02 16.86 15 370585 30689 110188010
Sensory loss 58.94 16.86 182 370418 21275 110197424
Joint ankylosis 58.83 16.86 56 370544 2441 110216258
Affect lability 58.74 16.86 166 370434 18471 110200228
Urinary incontinence 58.70 16.86 46 370554 48541 110170158
Ear pain 58.38 16.86 341 370259 52885 110165814
Swollen tongue 58.02 16.86 70 370530 60292 110158407
Bone pain 58.00 16.86 80 370520 65053 110153646
Gangrene 57.95 16.86 152 370448 16189 110202510
Spondyloarthropathy 57.88 16.86 46 370554 1568 110217131
Tonsillitis 57.84 16.86 101 370499 8112 110210587
Bronchospasm 57.69 16.86 15 370585 30224 110188475
Visual acuity reduced 57.61 16.86 18 370582 32155 110186544
Anuria 57.39 16.86 7 370593 24334 110194365
Abdominal pain 57.20 16.86 1296 369304 511693 109707006
Underdose 57.15 16.86 387 370213 63167 110155532
Atrial flutter 57.15 16.86 7 370593 24255 110194444
Alanine aminotransferase abnormal 57.12 16.86 108 370492 9226 110209473
Head injury 56.85 16.86 37 370563 42980 110175719
Petechiae 56.75 16.86 6 370594 23311 110195388
Pseudomonas infection 56.73 16.86 12 370588 27841 110190858
Ischaemic stroke 56.59 16.86 34 370566 41229 110177470
Joint destruction 56.59 16.86 118 370482 10825 110207874
Swollen joint count 56.38 16.86 103 370497 8571 110210128
Drug-induced liver injury 56.26 16.86 633 369967 119434 110099265
Cough 56.18 16.86 1150 369450 460491 109758208
Blood pressure diastolic decreased 56.00 16.86 25 370575 35860 110182839
Iron deficiency anaemia 55.90 16.86 18 370582 31541 110187158
Hyperthermia 55.77 16.86 4 370596 21268 110197431
Toxic skin eruption 55.75 16.86 12 370588 27503 110191196
Impaired quality of life 55.19 16.86 16 370584 30001 110188698
Rash 55 16.86 3317 367283 817647 109401052
Therapy cessation 54.91 16.86 296 370304 44561 110174138
Heart rate irregular 54.88 16.86 23 370577 34251 110184448
Retching 54.78 16.86 6 370594 22676 110196023
Pain of skin 54.19 16.86 169 370431 19860 110198839
End stage renal disease 53.63 16.86 5 370595 21468 110197231
Psoriasis area severity index increased 53.54 16.86 24 370576 271 110218428
Product substitution issue 53.48 16.86 7 370593 23054 110195645
Urosepsis 53.44 16.86 18 370582 30657 110188042
Poor venous access 53.28 16.86 9 370591 24513 110194186
Metastases to liver 53.14 16.86 26 370574 35360 110183339
Hot flush 53.10 16.86 87 370513 65949 110152750
Hyperlipidaemia 52.84 16.86 27 370573 35821 110182878
Procedural pain 52.10 16.86 27 370573 35538 110183161
Pneumonia bacterial 52.10 16.86 12 370588 26249 110192450
Blood magnesium decreased 51.74 16.86 4 370596 19992 110198707
Pneumothorax 51.38 16.86 27 370573 35258 110183441
Sneezing 51.30 16.86 228 370372 31756 110186943
No adverse event 50.77 16.86 107 370493 73732 110144967
Respiratory rate increased 50.69 16.86 11 370589 25072 110193627
Renal injury 50.60 16.86 3 370597 18710 110199989
Blood potassium increased 50.59 16.86 24 370576 33225 110185474
Electrocardiogram abnormal 50.58 16.86 3 370597 18706 110199993
Metastases to central nervous system 50.41 16.86 8 370592 22809 110195890
Motor dysfunction 50.28 16.86 188 370412 24218 110194481
Myocardial ischaemia 49.47 16.86 14 370586 26670 110192029
Immune thrombocytopenia 49.44 16.86 8 370592 22486 110196213
Hepatic enzyme 49.40 16.86 73 370527 5090 110213609
Rhinorrhoea 49.35 16.86 544 370056 102122 110116577
Cardiomegaly 49.20 16.86 18 370582 29112 110189587
Klebsiella infection 49.08 16.86 5 370595 20004 110198695
Mania 48.98 16.86 6 370594 20790 110197909
Pneumonia 48.98 16.86 2420 368180 874294 109344405
Skin laceration 48.89 16.86 26 370574 33727 110184972
Purpura 48.67 16.86 11 370589 24377 110194322
Flatulence 48.53 16.86 62 370538 52087 110166612
Oesophagitis 48.06 16.86 18 370582 28697 110190002
Urinary tract infection 47.75 16.86 787 369813 325495 109893204
Drug tolerance 47.73 16.86 143 370457 16442 110202257
Diabetes mellitus inadequate control 47.64 16.86 20 370580 29755 110188944
Polyuria 47.49 16.86 3 370597 17735 110200964
Metastases to bone 47.19 16.86 23 370577 31349 110187350
Cerebrovascular accident 46.97 16.86 385 370215 180899 110037800
Tooth disorder 46.93 16.86 20 370580 29489 110189210
Hepatitis 46.93 16.86 485 370115 89569 110129130
Hypogammaglobulinaemia 46.78 16.86 6 370594 20070 110198629
Complication associated with device 46.77 16.86 6 370594 20067 110198632
Sudden death 46.73 16.86 12 370588 24383 110194316
Oropharyngeal pain 46.71 16.86 674 369926 134602 110084097
Depression 46.63 16.86 1393 369207 315942 109902757
Injection site pruritus 46.61 16.86 62 370538 51196 110167503
Weight decreased 46.53 16.86 1203 369397 466854 109751845
Tendonitis 46.51 16.86 192 370408 25891 110192808
Gastric ulcer 46.50 16.86 39 370561 39788 110178911
Tenosynovitis 46.49 16.86 140 370460 16143 110202556
Food allergy 46.39 16.86 6 370594 19942 110198757
Dialysis 45.39 16.86 6 370594 19613 110199086
Enterococcal infection 45.31 16.86 7 370593 20359 110198340
Therapeutic response shortened 45.29 16.86 208 370392 29375 110189324
Gait disturbance 45.23 16.86 1237 369363 276971 109941728
Hypernatraemia 44.95 16.86 4 370596 17829 110200870
Axial spondyloarthritis 44.94 16.86 31 370569 847 110217852
Inflammatory pain 44.76 16.86 39 370561 1514 110217185
Chest discomfort 44.68 16.86 370 370230 173478 110045221
Drug level decreased 44.56 16.86 5 370595 18543 110200156
Hemiplegia 44.06 16.86 172 370428 22610 110196089
Muscle rigidity 43.83 16.86 13 370587 24018 110194681
Dementia 43.58 16.86 26 370574 31647 110187052
Impaired work ability 43.49 16.86 17 370583 26402 110192297
Pyoderma gangrenosum 43.42 16.86 71 370529 5405 110213294
Arteriosclerosis coronary artery 43.31 16.86 15 370585 25103 110193596
Creatinine renal clearance decreased 43.22 16.86 10 370590 21805 110196894
Palpitations 43.15 16.86 334 370266 158878 110059821
Metastases to lung 42.94 16.86 12 370588 23051 110195648
Thirst 42.91 16.86 10 370590 21697 110197002
Tonsillar ulcer 42.90 16.86 24 370576 447 110218252
Macular degeneration 42.77 16.86 10 370590 21649 110197050
Epstein-Barr virus infection 42.71 16.86 6 370594 18732 110199967
Delirium 42.44 16.86 662 369938 134363 110084336
Atrioventricular block complete 42.27 16.86 8 370592 20074 110198625
Foetal death 42.11 16.86 3 370597 16042 110202657
Sleep apnoea syndrome 42.05 16.86 44 370556 40403 110178296
Spinal fusion surgery 41.93 16.86 94 370506 9062 110209637
Injection site haemorrhage 41.83 16.86 220 370380 32808 110185891
Dysphagia 41.74 16.86 322 370278 153278 110065421
Gastric haemorrhage 41.70 16.86 3 370597 15912 110202787
Tricuspid valve incompetence 41.61 16.86 14 370586 23859 110194840
Pyrexia 41.54 16.86 2526 368074 895739 109322960
Blood lactic acid increased 41.41 16.86 3 370597 15818 110202881
Diarrhoea 41.24 16.86 3274 367326 1136231 109082468
Vomiting 41.22 16.86 2566 368034 908109 109310590
Papule 40.90 16.86 99 370501 10034 110208665
Haemolysis 40.83 16.86 3 370597 15636 110203063
Encephalitis 40.74 16.86 7 370593 18832 110199867
Prothrombin time prolonged 40.61 16.86 5 370595 17256 110201443
Concomitant disease aggravated 40.57 16.86 134 370466 16230 110202469
Cholecystitis 40.44 16.86 18 370582 25864 110192835
Withdrawal syndrome 40.12 16.86 28 370572 31352 110187347
Mental impairment 39.94 16.86 13 370587 22626 110196073
Therapeutic response unexpected 39.82 16.86 15 370585 23828 110194871
Pulmonary toxicity 39.71 16.86 6 370594 17740 110200959
General symptom 39.60 16.86 90 370510 8756 110209943
Skin disorder 39.59 16.86 263 370337 42650 110176049
Lip swelling 39.58 16.86 68 370532 50599 110168100
Product distribution issue 39.51 16.86 60 370540 4286 110214413
Sinus disorder 39.41 16.86 215 370385 32513 110186186
Hypoacusis 39.22 16.86 36 370564 35155 110183544
Fear of injection 39.16 16.86 90 370510 8821 110209878
Throat irritation 39.04 16.86 75 370525 53477 110165222
Gout 38.90 16.86 39 370561 36527 110182172
Psychomotor hyperactivity 38.79 16.86 10 370590 20267 110198432
Wrong technique in device usage process 38.75 16.86 77 370523 6824 110211875
Duodenal ulcer 38.55 16.86 9 370591 19505 110199194
Faecaloma 38.52 16.86 3 370597 14905 110203794
Blood calcium increased 38.37 16.86 7 370593 18033 110200666
Nervous system disorder 38.36 16.86 30 370570 31691 110187008
Anal incontinence 38.07 16.86 13 370587 21951 110196748
Pneumonia fungal 38.04 16.86 3 370597 14751 110203948
Hypertensive crisis 38.00 16.86 17 370583 24355 110194344
Self-consciousness 37.84 16.86 17 370583 193 110218506
Lacrimation increased 37.77 16.86 29 370571 30921 110187778
Dizziness postural 37.58 16.86 3 370597 14606 110204093
Vasculitis 37.32 16.86 39 370561 35834 110182865
Proctitis 37.25 16.86 6 370594 16921 110201778
Pleuritic pain 37.19 16.86 5 370595 16135 110202564
Pustule 37.12 16.86 52 370548 3452 110215247
Coordination abnormal 36.87 16.86 175 370425 25053 110193646
Guttate psoriasis 36.86 16.86 23 370577 528 110218171
Confusional state 36.83 16.86 1922 368678 466758 109751941
Staphylococcal sepsis 36.63 16.86 7 370593 17447 110201252
Thinking abnormal 36.58 16.86 4 370596 15136 110203563
Ventricular extrasystoles 36.56 16.86 15 370585 22626 110196073
Device defective 36.51 16.86 54 370546 3768 110214931
Product storage error 36.45 16.86 157 370443 21571 110197128
Atrioventricular block first degree 36.38 16.86 3 370597 14222 110204477
Faeces discoloured 36.35 16.86 36 370564 33912 110184787
Vein rupture 36.31 16.86 44 370556 2531 110216168
Acute coronary syndrome 36.22 16.86 16 370584 23096 110195603
Hydronephrosis 36.22 16.86 12 370588 20653 110198046
COVID-19 pneumonia 35.78 16.86 43 370557 37100 110181599
Hip fracture 35.69 16.86 39 370561 35112 110183587
Ligament calcification 35.54 16.86 17 370583 225 110218474
Depressed mood 35.54 16.86 96 370504 60713 110157986
Blood glucose decreased 35.52 16.86 28 370572 29460 110189239
Rash vesicular 35.45 16.86 119 370481 14533 110204166
Embolism 35.34 16.86 6 370594 16283 110202416
Fluid retention 35.31 16.86 179 370421 94128 110124571
Acute pulmonary oedema 35.29 16.86 7 370593 16989 110201710
Pulmonary thrombosis 35.24 16.86 3 370597 13860 110204839
Intestinal ischaemia 35.01 16.86 6 370594 16173 110202526
Hyperthyroidism 34.97 16.86 28 370572 29233 110189466
Dermatitis bullous 34.80 16.86 8 370592 17521 110201178
Eating disorder 34.69 16.86 199 370401 30659 110188040
Aspiration 34.31 16.86 31 370569 30502 110188197
Restless legs syndrome 34.18 16.86 20 370580 24606 110194093
Ear injury 34.15 16.86 19 370581 350 110218349
Eye irritation 34.10 16.86 37 370563 33415 110185284
Rhinitis allergic 33.98 16.86 9 370591 17913 110200786
Vaginal haemorrhage 33.91 16.86 21 370579 25053 110193646
Blood pressure systolic increased 33.70 16.86 153 370447 82838 110135861
Haemolytic anaemia 33.56 16.86 14 370586 20906 110197793
Cholangitis 33.35 16.86 7 370593 16328 110202371
Nasal polyps 33.17 16.86 3 370597 13197 110205502
Forced expiratory volume decreased 33.09 16.86 3 370597 13173 110205526
Erysipelas 32.85 16.86 108 370492 13050 110205649
Erythema multiforme 32.45 16.86 15 370585 21082 110197617
Ecchymosis 32.32 16.86 9 370591 17329 110201370
Terminal insomnia 32.15 16.86 36 370564 1902 110216797
Post inflammatory pigmentation change 31.91 16.86 24 370576 753 110217946
Product administration error 31.86 16.86 47 370553 37170 110181529
Fracture 31.84 16.86 22 370578 24766 110193933
Speech disorder 31.78 16.86 103 370497 61466 110157233
Eye pain 31.67 16.86 76 370524 50023 110168676
Osteonecrosis 31.51 16.86 40 370560 33701 110184998
Respiratory disorder 31.49 16.86 372 370228 71010 110147689
Nocturia 31.34 16.86 9 370591 16981 110201718
Lymphoedema 31.31 16.86 6 370594 14923 110203776
Paranoia 31.30 16.86 18 370582 22356 110196343
Photosensitivity reaction 31.20 16.86 24 370576 25565 110193134
Amylase increased 31.04 16.86 3 370597 12516 110206183
Sleep disorder due to general medical condition, hypersomnia type 30.95 16.86 36 370564 1983 110216716
Escherichia infection 30.78 16.86 21 370579 23795 110194904
Left ventricular hypertrophy 30.76 16.86 4 370596 13240 110205459
Vulvovaginal erythema 30.66 16.86 20 370580 497 110218202
Vulval disorder 30.58 16.86 25 370575 888 110217811
Therapy partial responder 30.57 16.86 48 370552 37013 110181686
Movement disorder 30.56 16.86 218 370382 36186 110182513
Chronic disease 30.24 16.86 15 370585 216 110218483
Herpes zoster 30.00 16.86 226 370374 108153 110110546
Feeling hot 29.90 16.86 450 370150 90656 110128043
Stress cardiomyopathy 29.85 16.86 8 370592 15798 110202901
Overlap syndrome 29.84 16.86 82 370518 8977 110209722
Pulmonary haemorrhage 29.83 16.86 9 370591 16447 110202252
Injection site rash 29.80 16.86 21 370579 23398 110195301
Exposure to toxic agent 29.58 16.86 4 370596 12854 110205845
Decubitus ulcer 29.58 16.86 12 370588 18224 110200475
Vulvovaginal candidiasis 29.37 16.86 45 370555 3240 110215459
Fear 29.25 16.86 21 370579 23172 110195527
Hypermobility syndrome 29.20 16.86 20 370580 540 110218159
Gingival bleeding 29.15 16.86 15 370585 19824 110198875
Nephropathy 29.13 16.86 5 370595 13462 110205237
Myasthenia gravis 29.12 16.86 18 370582 21493 110197206
HLA-B*27 positive 28.91 16.86 13 370587 148 110218551
Limb discomfort 28.89 16.86 235 370365 40619 110178080
Post procedural complication 28.86 16.86 28 370572 26630 110192069
Ileus paralytic 28.61 16.86 3 370597 11734 110206965
Impaired gastric emptying 28.56 16.86 5 370595 13270 110205429
Cushingoid 28.54 16.86 3 370597 11709 110206990
Facial pain 28.52 16.86 8 370592 15331 110203368
Cutaneous T-cell lymphoma 28.37 16.86 45 370555 3339 110215360
Diffuse large B-cell lymphoma 28.28 16.86 9 370591 15889 110202810
Oral lichen planus 28.18 16.86 24 370576 903 110217796
Nystagmus 28.12 16.86 3 370597 11574 110207125
Device occlusion 28.09 16.86 8 370592 15177 110203522
Oedema peripheral 27.97 16.86 863 369737 327797 109890902
Rash papular 27.70 16.86 31 370569 27608 110191091
Lipase increased 27.61 16.86 14 370586 18658 110200041
Blood loss anaemia 27.44 16.86 13 370587 18012 110200687
Bladder cancer 27.44 16.86 17 370583 20275 110198424
Partial seizures 27.41 16.86 3 370597 11346 110207353
Hypertriglyceridaemia 27.25 16.86 10 370590 16144 110202555
Dermatitis psoriasiform 27.22 16.86 46 370554 3598 110215101
Disease recurrence 27.18 16.86 108 370492 60676 110158023
Product prescribing error 27.00 16.86 277 370323 51054 110167645
Productive cough 26.83 16.86 249 370351 114056 110104643
Gastrointestinal toxicity 26.79 16.86 3 370597 11145 110207554
Undifferentiated connective tissue disease 26.69 16.86 14 370586 228 110218471
Venous injury 26.64 16.86 24 370576 974 110217725
Rash macular 26.64 16.86 56 370544 38630 110180069
Scab 26.47 16.86 101 370499 13135 110205564
Rash erythematous 26.45 16.86 163 370437 81669 110137030
Secretion discharge 26.43 16.86 136 370464 20108 110198591
Intestinal perforation 26.36 16.86 19 370581 20925 110197774
Thymoma benign 26.34 16.86 9 370591 45 110218654
Product dose omission in error 26.27 16.86 24 370576 23488 110195211
Cholecystitis acute 26.23 16.86 10 370590 15772 110202927
Splenomegaly 26.21 16.86 26 370574 24472 110194227
Blood pressure abnormal 26.13 16.86 22 370578 22402 110196297
Gingival pain 26.11 16.86 10 370590 15726 110202973
Exposure via skin contact 26.10 16.86 6 370594 13141 110205558
Cardiac failure chronic 26.06 16.86 7 370593 13804 110204895
Cystitis 26.05 16.86 337 370263 65699 110153000
Haemorrhagic stroke 26 16.86 7 370593 13782 110204917
Device breakage 25.94 16.86 7 370593 13762 110204937
Sensory disturbance 25.88 16.86 13 370587 17416 110201283
Peripheral coldness 25.82 16.86 15 370585 18525 110200174
Neurological symptom 25.76 16.86 10 370590 15598 110203101
Therapeutic response decreased 25.51 16.86 460 370140 96039 110122660
Spinal fracture 25.41 16.86 23 370577 22610 110196089
Vulvovaginal swelling 25.32 16.86 19 370581 594 110218105
Incontinence 25.32 16.86 12 370588 16623 110202076
Mouth haemorrhage 25.15 16.86 7 370593 13481 110205218
Abnormal dreams 25.04 16.86 6 370594 12774 110205925
Pathogen resistance 25.03 16.86 14 370586 17658 110201041
Feeling jittery 25.03 16.86 9 370591 14713 110203986
Peritonitis bacterial 24.90 16.86 3 370597 10530 110208169
Mood altered 24.87 16.86 21 370579 21354 110197345
Pulse absent 24.85 16.86 4 370596 11288 110207411
Endocarditis 24.82 16.86 7 370593 13364 110205335
Dysphonia 24.67 16.86 151 370449 75778 110142921
Brain natriuretic peptide increased 24.61 16.86 4 370596 11205 110207494
Coronary artery occlusion 24.59 16.86 11 370589 15761 110202938
Blood albumin decreased 24.58 16.86 34 370566 27618 110191081
Onycholysis 24.54 16.86 38 370562 2761 110215938
Cardiovascular disorder 24.53 16.86 24 370576 22736 110195963
Breast cancer metastatic 24.52 16.86 4 370596 11177 110207522
Feeling cold 24.43 16.86 48 370552 33939 110184760
Neutrophilia 24.28 16.86 3 370597 10326 110208373
Chromaturia 24.24 16.86 38 370562 29322 110189377
Peripheral ischaemia 24.15 16.86 4 370596 11054 110207645
Enterocolitis 24.10 16.86 17 370583 18932 110199767
Abdominal pain lower 24.01 16.86 56 370544 37227 110181472
Ileal ulcer 23.93 16.86 30 370570 1787 110216912
Normochromic normocytic anaemia 23.93 16.86 7 370593 13050 110205649
Systemic inflammatory response syndrome 23.89 16.86 7 370593 13036 110205663
Colitis ischaemic 23.82 16.86 15 370585 17735 110200964
Large intestine perforation 23.81 16.86 13 370587 16616 110202083
Eye pruritus 23.80 16.86 46 370554 32729 110185970
Radiculopathy 23.74 16.86 18 370582 19318 110199381
Tooth extraction 23.74 16.86 7 370593 12984 110205715
Intraocular pressure increased 23.61 16.86 4 370596 10872 110207827
Back disorder 23.57 16.86 135 370465 20787 110197912
Diabetes mellitus 23.53 16.86 216 370384 99165 110119534
Poor quality sleep 23.51 16.86 36 370564 28041 110190658
Genital ulceration 23.49 16.86 31 370569 1944 110216755
Pelvic fracture 23.48 16.86 9 370591 14145 110204554
Haemorrhoids 23.44 16.86 53 370547 35619 110183080
Eye injury 23.40 16.86 68 370532 7687 110211012
Blood pressure systolic decreased 23.22 16.86 8 370592 13433 110205266
Glycosylated haemoglobin increased 23.12 16.86 27 370573 23592 110195107
Gastritis 23.02 16.86 97 370503 53602 110165097
Left ventricular failure 23.01 16.86 5 370595 11384 110207315
Injection site bruising 22.99 16.86 268 370332 50995 110167704
Papulopustular rosacea 22.94 16.86 8 370592 43 110218656
Respiratory syncytial virus infection 22.74 16.86 10 370590 14474 110204225
Body surface area increased 22.70 16.86 11 370589 150 110218549
Injection site pain 22.57 16.86 440 370160 177482 110041217
Staphylococcal bacteraemia 22.54 16.86 14 370586 16674 110202025
Mood swings 22.41 16.86 26 370574 22786 110195913
Blood parathyroid hormone decreased 22.28 16.86 95 370505 12994 110205705
Injection site swelling 22.16 16.86 119 370481 61671 110157028
Gastroenteritis 22.11 16.86 62 370538 38738 110179961
Hepatitis B 22.09 16.86 3 370597 9609 110209090
Congestive cardiomyopathy 22.04 16.86 10 370590 14209 110204490
Skin fissures 22.02 16.86 149 370451 24309 110194390
Panniculitis 21.99 16.86 107 370493 15475 110203224
Blood thyroid stimulating hormone increased 21.81 16.86 7 370593 12294 110206405
Face oedema 21.77 16.86 50 370550 33419 110185280
Cholecystitis chronic 21.75 16.86 3 370597 9497 110209202
Bacterial infection 21.75 16.86 80 370520 45956 110172743
Cardiac disorder 21.62 16.86 158 370442 76122 110142577
Periorbital oedema 21.58 16.86 4 370596 10188 110208511
Groin infection 21.50 16.86 22 370578 1048 110217651
Rhesus antigen positive 21.48 16.86 10 370590 124 110218575
Product dispensing error 21.48 16.86 110 370490 16235 110202464
Rotator cuff syndrome 21.45 16.86 15 370585 16779 110201920
Palate injury 21.30 16.86 9 370591 87 110218612
Genital candidiasis 21.24 16.86 12 370588 228 110218471
Abscess sweat gland 21.03 16.86 6 370594 14 110218685
Carotid artery stenosis 21.03 16.86 3 370597 9260 110209439
Throat tightness 21.01 16.86 51 370549 33438 110185261
Post procedural haemorrhage 20.97 16.86 13 370587 15499 110203200
Product supply issue 20.97 16.86 42 370558 3744 110214955
Lower respiratory tract infection viral 20.94 16.86 25 370575 1416 110217283
Psychiatric symptom 20.88 16.86 3 370597 9210 110209489
Leukoencephalopathy 20.83 16.86 3 370597 9192 110209507
Product administration interrupted 20.79 16.86 6 370594 11286 110207413
Premature labour 20.76 16.86 3 370597 9169 110209530
Electrocardiogram ST segment elevation 20.72 16.86 3 370597 9157 110209542
Eosinophil count increased 20.69 16.86 24 370576 21034 110197665
Blood uric acid increased 20.65 16.86 25 370575 21504 110197195
Organising pneumonia 20.59 16.86 11 370589 14232 110204467
Blood chloride decreased 20.59 16.86 3 370597 9112 110209587
Colorectal cancer 20.58 16.86 3 370597 9111 110209588
Anger 20.53 16.86 20 370580 18987 110199712
Iron deficiency 20.47 16.86 19 370581 18457 110200242
Iritis 20.46 16.86 47 370553 4605 110214094
Respiration abnormal 20.45 16.86 4 370596 9805 110208894
Tongue ulceration 20.42 16.86 48 370552 4774 110213925
Pneumonia viral 20.41 16.86 6 370594 11151 110207548
Heavy menstrual bleeding 20.40 16.86 15 370585 16350 110202349
Pseudomonal sepsis 20.38 16.86 3 370597 9043 110209656
Increased tendency to bruise 20.31 16.86 7 370593 11751 110206948
Alcohol poisoning 20.30 16.86 3 370597 9017 110209682
Urine output decreased 20.24 16.86 22 370578 19854 110198845
Hypotonia 20.19 16.86 14 370586 15731 110202968
Meningitis 20.15 16.86 7 370593 11695 110207004
Blood glucose abnormal 20.15 16.86 9 370591 12907 110205792
Bundle branch block left 20.08 16.86 9 370591 12879 110205820
Aortic valve incompetence 19.92 16.86 6 370594 10975 110207724
Hyperuricaemia 19.89 16.86 12 370588 14519 110204180
Dyshidrotic eczema 19.87 16.86 18 370582 736 110217963
Polyarthritis 19.84 16.86 120 370480 18843 110199856
Carotid artery occlusion 19.73 16.86 4 370596 9561 110209138
Euphoric mood 19.72 16.86 3 370597 8824 110209875
Dry eye 19.71 16.86 108 370492 55685 110163014
Protein total decreased 19.66 16.86 6 370594 10884 110207815
Product preparation error 19.63 16.86 6 370594 10873 110207826
Increased appetite 19.63 16.86 13 370587 14964 110203735
Bone density decreased 19.61 16.86 15 370585 16027 110202672
Kidney infection 19.61 16.86 150 370450 25449 110193250
Skin injury 19.50 16.86 42 370558 3940 110214759
Exercise tolerance decreased 19.48 16.86 8 370592 12059 110206640
Embolic stroke 19.46 16.86 3 370597 8740 110209959
Pollakiuria 19.46 16.86 79 370521 44116 110174583
Parosmia 19.32 16.86 10 370590 13170 110205529
Asphyxia 19.09 16.86 12 370588 14203 110204496
Xyphoid retraction 19.06 16.86 10 370590 163 110218536
Product use in unapproved indication 19.06 16.86 1744 368856 445633 109773066
Aortic stenosis 19.00 16.86 10 370590 13049 110205650
Systemic candida 18.93 16.86 5 370595 9969 110208730
Clonal haematopoiesis 18.90 16.86 10 370590 166 110218533
Diastolic dysfunction 18.80 16.86 9 370591 12395 110206304
Blood triglycerides increased 18.79 16.86 32 370568 23894 110194805
Autoimmune haemolytic anaemia 18.76 16.86 6 370594 10561 110208138
Ear infection fungal 18.75 16.86 11 370589 225 110218474
Collagen-vascular disease 18.70 16.86 8 370592 80 110218619
Chest X-ray abnormal 18.69 16.86 3 370597 8484 110210215
Arteriosclerosis 18.66 16.86 34 370566 24733 110193966
Abortion spontaneous 18.65 16.86 56 370544 34226 110184473
Metabolic disorder 18.60 16.86 6 370594 10504 110208195
Procedural complication 18.45 16.86 3 370597 8402 110210297
Central nervous system lesion 18.44 16.86 15 370585 15538 110203161
Vulval cancer stage III 18.39 16.86 5 370595 9 110218690
Erectile dysfunction 18.39 16.86 21 370579 18535 110200164
Marginal zone lymphoma 18.37 16.86 11 370589 234 110218465
Cerebral atrophy 18.33 16.86 4 370596 9081 110209618
Dysstasia 18.31 16.86 180 370420 32806 110185893
Gastric cancer 18.26 16.86 7 370593 11001 110207698
Oral lichenoid reaction 18.18 16.86 10 370590 180 110218519
Hiatus hernia 18.15 16.86 41 370559 27565 110191134
Musculoskeletal discomfort 18.07 16.86 138 370462 23400 110195299
Dermatitis acneiform 18.07 16.86 10 370590 12685 110206014
Cutaneous B-cell lymphoma 18.06 16.86 9 370591 131 110218568
Tenderness 18.02 16.86 164 370436 29273 110189426
Multiple-drug resistance 18.02 16.86 11 370589 13224 110205475
Ammonia increased 17.99 16.86 3 370597 8247 110210452
Proctalgia 17.98 16.86 11 370589 13211 110205488
Upper-airway cough syndrome 17.94 16.86 16 370584 15841 110202858
Tension headache 17.92 16.86 5 370595 9613 110209086
Device difficult to use 17.87 16.86 22 370578 18783 110199916
Emphysema 17.86 16.86 24 370576 19732 110198967
Endophthalmitis 17.80 16.86 3 370597 8184 110210515
Atrioventricular block second degree 17.78 16.86 3 370597 8178 110210521
Muscle swelling 17.73 16.86 20 370580 1065 110217634
Genital cyst 17.61 16.86 7 370593 57 110218642
Escherichia urinary tract infection 17.46 16.86 17 370583 16145 110202554
Ventricular arrhythmia 17.43 16.86 6 370594 10081 110208618
Serum ferritin increased 17.35 16.86 9 370591 11838 110206861
Treatment delayed 17.23 16.86 14 370586 493 110218206
Flank pain 17.20 16.86 32 370568 23098 110195601
Rhinovirus infection 17.20 16.86 9 370591 11780 110206919
Eye haemorrhage 17.16 16.86 9 370591 11765 110206934
Wound dehiscence 17.13 16.86 3 370597 7959 110210740
Pre-eclampsia 17.07 16.86 4 370596 8646 110210053
Non-small cell lung cancer 17.05 16.86 3 370597 7932 110210767
Granuloma 17.03 16.86 70 370530 9420 110209279
Dysuria 16.95 16.86 125 370475 60106 110158593
Micturition urgency 16.93 16.86 24 370576 19296 110199403
Eyelid ptosis 16.89 16.86 12 370588 13315 110205384
Dental caries 16.86 16.86 11 370589 12762 110205937

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AC10 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
FDA MoA N0000191494 Interleukin-17A Antagonists
FDA EPC N0000191495 Interleukin-17A Antagonist
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent

Related Drugs by ATC class:

L04AC Interleukin inhibitors 18 drugs
anakinrabasiliximabbimekizumabbrodalumabcanakinumabdaclizumabguselkumabixekizumabmirikizumabrilonaceptrisankizumabsarilumab show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriatic arthritis indication 156370009 DOID:9008
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Non-radiographic axial spondyloarthritis indication 713777005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Interleukin-17A Cytokine ANTIBODY BINDING SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D09967 KEGG_DRUG
4034154 VUID
N0000191427 NUI
4034154 VANDF
CHEBI:750145 CHEBI
CHEMBL1743068 ChEMBL_ID
C555450 MESH_SUPPLEMENTAL_RECORD_UI
8078 IUPHAR_LIGAND_ID
DB09029 DRUGBANK_ID
1599788 RXNORM
232493 MMSL
30871 MMSL
d08341 MMSL
015879 NDDF
708822004 SNOMEDCT_US
714689007 SNOMEDCT_US
C3179547 UMLSCUI
9182 INN_ID
DLG4EML025 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-0639 INJECTION 150 mg SUBCUTANEOUS BLA 31 sections
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-1056 INJECTION 75 mg SUBCUTANEOUS BLA 31 sections
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-1070 INJECTION 300 mg SUBCUTANEOUS BLA 31 sections
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-1168 INJECTION, SOLUTION, CONCENTRATE 25 mg INTRAVENOUS BLA 31 sections