All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

secukinumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
human origin	4934	1229022-83-6

Description:

Molecule

Description

Synonyms: secukinumab cosentyx AIN-457 AIN457

Secukinumab is a human IgG1 monoclonal antibody that selectively binds to the interleukin-17A (IL-17A) cytokine and inhibits its interaction with the IL-17 receptor. IL-17A is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Secukinumab inhibits the release of proinflammatory cytokines and chemokines. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
10	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 14, 2015	EMA	NOVARTIS EUROPHARM LIMITED
Jan. 21, 2015	FDA	NOVARTIS PHARMS CORP
Dec. 26, 2014	PMDA	Novartis Pharma

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	1203.85	15.14	5382	150156	1039383	62294101
Psoriasis	1111.42	15.14	1212	154326	85745	63247739
Psoriatic arthropathy	858.72	15.14	1089	154449	90431	63243053
Inappropriate schedule of product administration	834.79	15.14	1146	154392	102819	63230665
Incorrect dose administered	785.32	15.14	847	154691	59121	63274363
Liver injury	723.61	15.14	815	154723	59705	63273779
Musculoskeletal stiffness	535.67	15.14	1308	154230	183310	63150174
Toxicity to various agents	532.70	15.14	16	155522	247234	63086250
Device malfunction	531.59	15.14	401	155137	17456	63316028
Skin plaque	505.94	15.14	292	155246	8028	63325456
Acute kidney injury	468.58	15.14	50	155488	263365	63070119
Therapy interrupted	445.12	15.14	470	155068	31985	63301499
Hypotension	427.79	15.14	76	155462	272528	63060956
Drug interaction	406.17	15.14	44	155494	229087	63104397
Anaemia	405.45	15.14	109	155429	293321	63040163
Arthralgia	398.58	15.14	2569	152969	567141	62766343
Therapeutic product effect incomplete	369.81	15.14	893	154645	124163	63209321
Death	322.05	15.14	267	155271	374114	62959370
Neutropenia	316.81	15.14	31	155507	174974	63158510
Treatment failure	313.72	15.14	1136	154402	197907	63135577
Accidental exposure to product	311.98	15.14	360	155178	27045	63306439
Device issue	306.00	15.14	333	155205	23448	63310036
Skin exfoliation	293.91	15.14	440	155098	42662	63290822
Pain	279.63	15.14	2903	152635	737725	62595759
Fibromyalgia	265.73	15.14	600	154938	79820	63253664
Arthritis	248.58	15.14	735	154803	115186	63218298
Nasopharyngitis	246.23	15.14	1252	154286	253005	63080479
Constipation	235.33	15.14	129	155409	224814	63108670
Hyponatraemia	234.62	15.14	9	155529	111891	63221593
Incorrect dose administered by device	226.19	15.14	138	155400	4210	63329274
Macule	223.40	15.14	106	155432	1922	63331562
Arthropathy	222.29	15.14	1149	154389	233643	63099841
Skin lesion	221.51	15.14	322	155216	30399	63303085
Rheumatoid arthritis	220.48	15.14	1213	154325	252606	63080878
Glossodynia	217.94	15.14	942	154596	177934	63155550
Dyspnoea	213.52	15.14	866	154672	660447	62673037
Thrombocytopenia	210.75	15.14	55	155483	151102	63182382
Disease progression	208.90	15.14	27	155511	122731	63210753
Platelet count decreased	206.39	15.14	22	155516	116100	63217384
Product use issue	203.07	15.14	1071	154467	219449	63114035
Somnolence	202.63	15.14	92	155446	178593	63154891
Pemphigus	197.95	15.14	933	154605	182793	63150691
Skin haemorrhage	196.17	15.14	177	155361	9917	63323567
Dehydration	195.41	15.14	90	155448	173264	63160220
Systemic lupus erythematosus	195.34	15.14	1019	154519	207899	63125585
Wound	191.40	15.14	850	154688	162413	63171071
Haemoglobin decreased	189.79	15.14	60	155478	145425	63188059
Type 2 diabetes mellitus	188.52	15.14	456	155082	63412	63270072
Prescribed overdose	186.44	15.14	315	155223	33838	63299646
Malaise	185.94	15.14	1691	153847	414263	62919221
White blood cell count decreased	185.73	15.14	55	155483	139049	63194435
Malignant neoplasm progression	185.69	15.14	3	155535	82118	63251366
Enthesopathy	183.26	15.14	159	155379	8455	63325029
Drug intolerance	181.67	15.14	1336	154202	307325	63026159
Pancytopenia	181.20	15.14	15	155523	96918	63236566
Synovitis	180.48	15.14	920	154618	185998	63147486
Rheumatic fever	179.98	15.14	354	155184	42757	63290727
Inflammation	177.58	15.14	523	155015	81750	63251734
Cardiac arrest	173.88	15.14	14	155524	92531	63240953
Seronegative arthritis	169.30	15.14	111	155427	3848	63329636
Inflammatory bowel disease	168.94	15.14	111	155427	3862	63329622
Hypokalaemia	162.50	15.14	29	155509	103775	63229709
Abdominal discomfort	161.76	15.14	1340	154198	319545	63013939
Respiratory failure	160.45	15.14	28	155510	101830	63231654
Wrong technique in device usage process	159.05	15.14	103	155435	3495	63329989
Contraindicated product administered	158.36	15.14	993	154545	216655	63116829
Device defective	158.28	15.14	83	155455	1879	63331605
Therapeutic product effect decreased	158.16	15.14	909	154629	192278	63141206
Product storage error	157.79	15.14	189	155349	14767	63318717
Bradycardia	156.59	15.14	5	155533	73222	63260262
Mobility decreased	155.94	15.14	649	154889	120510	63212974
Renal failure	152.59	15.14	49	155489	117603	63215881
COVID-19	149.61	15.14	611	154927	112492	63220992
Drug abuse	148.11	15.14	7	155531	72511	63260973
Fall	147.92	15.14	481	155057	391853	62941631
Incorrect route of product administration	146.93	15.14	251	155287	27201	63306283
Therapeutic response shortened	145.18	15.14	162	155376	11726	63321758
Oxygen saturation decreased	142.52	15.14	23	155515	88562	63244922
Dislocation of vertebra	142.00	15.14	138	155400	8497	63324987
Seizure	140.17	15.14	75	155463	132559	63200925
Discomfort	139.89	15.14	792	154746	166582	63166902
Pruritus	138.94	15.14	1424	154114	360029	62973455
Swollen joint count increased	138.49	15.14	286	155252	35768	63297716
Hand deformity	138.22	15.14	762	154776	158695	63174789
C-reactive protein increased	137.64	15.14	527	155011	94180	63239304
Alopecia	137.55	15.14	1346	154192	336190	62997294
Cardiac failure	137.17	15.14	26	155512	89116	63244368
Pulmonary embolism	133.92	15.14	59	155479	116625	63216859
Depressed level of consciousness	133.60	15.14	4	155534	62074	63271410
Influenza	133.38	15.14	574	154964	108148	63225336
Oropharyngeal pain	132.61	15.14	520	155018	93967	63239517
Syncope	132.15	15.14	61	155477	117324	63216160
Joint swelling	131.72	15.14	1303	154235	326363	63007121
Osteoarthritis	130.01	15.14	520	155018	94823	63238661
Tremor	128.12	15.14	83	155455	132156	63201328
Injection site bruising	126.62	15.14	302	155236	41608	63291876
Rheumatoid factor positive	126.22	15.14	474	155064	83932	63249552
Pleural effusion	125.96	15.14	36	155502	93174	63240310
Cardio-respiratory arrest	125.05	15.14	5	155533	59954	63273530
Ear infection	124.91	15.14	284	155254	37929	63295555
Sepsis	124.38	15.14	115	155423	153008	63180476
Cardiac failure congestive	124.36	15.14	36	155502	92397	63241087
Tonsillitis	122.29	15.14	106	155432	5629	63327855
Intentional overdose	122.14	15.14	18	155520	74134	63259350
Gastrointestinal haemorrhage	122.12	15.14	25	155513	81151	63252333
Gait inability	119.38	15.14	342	155196	52617	63280867
Overdose	117.37	15.14	68	155470	115010	63218474
Hallucination	116.29	15.14	4	155534	54813	63278671
Loss of consciousness	115.99	15.14	73	155465	118048	63215436
Pericarditis	115.48	15.14	631	154907	130948	63202536
Retinitis	115.22	15.14	106	155432	6090	63327394
Maternal exposure during pregnancy	113.97	15.14	925	154613	219137	63114347
Uveitis	112.21	15.14	146	155392	12407	63321077
Blood cholesterol increased	111.16	15.14	491	155047	93541	63239943
Dactylitis	111.12	15.14	73	155465	2539	63330945
C-reactive protein abnormal	111.08	15.14	305	155233	45791	63287693
Blister	110.89	15.14	618	154920	129196	63204288
Injury	110.06	15.14	412	155126	72835	63260649
Ankylosing spondylitis	109.90	15.14	132	155406	10342	63323142
Coma	109.85	15.14	14	155524	64350	63269134
Duodenal ulcer perforation	109.71	15.14	464	155074	86745	63246739
Decreased immune responsiveness	109.41	15.14	93	155445	4808	63328676
Tachycardia	109.32	15.14	78	155460	118078	63215406
Neuropathy peripheral	109.21	15.14	72	155466	113595	63219889
Grip strength decreased	107.89	15.14	195	155343	22092	63311392
Balance disorder	106.24	15.14	37	155501	84385	63249099
Therapy non-responder	105.90	15.14	417	155121	75484	63258000
Papule	105.13	15.14	97	155441	5594	63327890
Intentional product misuse	104.57	15.14	13	155525	60904	63272580
Helicobacter infection	104.07	15.14	477	155061	92308	63241176
Atrial fibrillation	104.03	15.14	80	155458	116556	63216928
Multiple organ dysfunction syndrome	102.77	15.14	10	155528	56742	63276742
Hyperkalaemia	102.36	15.14	8	155530	54195	63279289
Facet joint syndrome	102.06	15.14	137	155401	12001	63321483
Lip dry	101.26	15.14	155	155383	15315	63318169
Illness	101.20	15.14	307	155231	48752	63284732
Hypoxia	99.67	15.14	14	155524	59778	63273706
Adjustment disorder with depressed mood	99.61	15.14	124	155414	10080	63323404
Needle issue	99.55	15.14	125	155413	10251	63323233
Skin fissures	99.54	15.14	131	155407	11257	63322227
Infection	96.22	15.14	920	154618	228253	63105231
Agitation	95.03	15.14	16	155522	59741	63273743
Metabolic acidosis	93.18	15.14	4	155534	45065	63288419
Bone erosion	92.19	15.14	160	155378	17557	63315927
Deep vein thrombosis postoperative	92.06	15.14	126	155412	11243	63322241
Wound infection	89.57	15.14	176	155362	21234	63312250
Interstitial lung disease	89.20	15.14	21	155517	61887	63271597
Anti-cyclic citrullinated peptide antibody positive	88.66	15.14	537	155001	115675	63217809
Hypoglycaemia	87.29	15.14	20	155518	60045	63273439
Multiple sclerosis relapse	86.58	15.14	9	155529	48469	63285015
Cognitive disorder	86.46	15.14	16	155522	55799	63277685
Joint stiffness	86.35	15.14	262	155276	41607	63291877
Nausea	84.72	15.14	1530	154008	852941	62480543
Pain in extremity	83.51	15.14	1206	154332	330280	63003204
Vomiting	83.44	15.14	923	154615	558694	62774790
Epistaxis	83.07	15.14	37	155501	72688	63260796
Hip arthroplasty	82.68	15.14	281	155257	47365	63286119
Pulmonary oedema	82.32	15.14	17	155521	54856	63278628
Bursitis	82.30	15.14	238	155300	36803	63296681
Mycotic allergy	82.25	15.14	43	155495	967	63332517
Peripheral venous disease	80.83	15.14	140	155398	15337	63318147
Joint dislocation	80.41	15.14	156	155382	18644	63314840
Laryngitis	80.28	15.14	147	155391	16820	63316664
Exostosis	79.82	15.14	151	155387	17711	63315773
Injection site haemorrhage	79.78	15.14	181	155357	24133	63309351
Red blood cell sedimentation rate	78.74	15.14	77	155461	4777	63328707
Rhinorrhoea	78.68	15.14	344	155194	65233	63268251
Lupus-like syndrome	78.11	15.14	137	155401	15158	63318326
Tonsillar ulcer	78.04	15.14	29	155509	274	63333210
Fear of injection	77.99	15.14	92	155446	7072	63326412
Autoimmune disorder	77.74	15.14	146	155392	17031	63316453
Lactic acidosis	77.20	15.14	4	155534	38283	63295201
Therapy cessation	76.86	15.14	205	155333	30252	63303232
Concomitant disease aggravated	76.84	15.14	103	155435	9009	63324475
Guttate psoriasis	76.28	15.14	32	155506	427	63333057
Pustular psoriasis	76.20	15.14	74	155464	4552	63328932
Red blood cell sedimentation rate increased	75.97	15.14	259	155279	43723	63289761
Hypersensitivity	75.75	15.14	1070	154468	291615	63041869
Product use in unapproved indication	75.66	15.14	720	154818	178360	63155124
Tenosynovitis	74.95	15.14	127	155411	13668	63319816
Suicide attempt	74.43	15.14	28	155510	60890	63272594
Septic shock	74.39	15.14	35	155503	66594	63266890
Pharyngitis streptococcal	74.22	15.14	110	155428	10562	63322922
Hyperglycaemia	74.19	15.14	8	155530	41859	63291625
Anti-cyclic citrullinated peptide antibody	73.92	15.14	87	155451	6671	63326813
Skin disorder	73.85	15.14	198	155340	29309	63304175
Drug reaction with eosinophilia and systemic symptoms	69.96	15.14	3	155535	33833	63299651
Osteonecrosis of jaw	69.79	15.14	4	155534	35119	63298365
Knee arthroplasty	69.39	15.14	290	155248	53916	63279568
Drug tolerance decreased	68.73	15.14	140	155398	17333	63316151
Hepatic function abnormal	68.70	15.14	6	155532	37136	63296348
Heart rate decreased	68.58	15.14	14	155524	45546	63287938
Swelling	67.77	15.14	998	154540	274380	63059104
Product prescribing error	67.40	15.14	178	155360	26111	63307373
Joint range of motion decreased	66.94	15.14	203	155335	32225	63301259
Dyspnoea exertional	66.83	15.14	32	155506	60270	63273214
Mental status changes	66.64	15.14	9	155529	39590	63293894
Tendonitis	66.57	15.14	148	155390	19467	63314017
Blood bilirubin increased	66.06	15.14	7	155531	37133	63296351
Hypercholesterolaemia	64.72	15.14	154	155384	21180	63312304
Respiratory arrest	64.01	15.14	4	155534	32641	63300843
Unresponsive to stimuli	63.83	15.14	5	155533	33811	63299673
Deep vein thrombosis	63.33	15.14	67	155471	83733	63249751
Plasma cell myeloma	63.27	15.14	7	155531	35898	63297586
Sinusitis	63.25	15.14	840	154698	225813	63107671
Foetal exposure during pregnancy	62.42	15.14	4	155534	31958	63301526
Pallor	62.25	15.14	3	155535	30565	63302919
Red blood cell count decreased	62.21	15.14	12	155526	40633	63292851
Hypocalcaemia	61.84	15.14	4	155534	31709	63301775
Mucosal inflammation	61.79	15.14	19	155519	46909	63286575
Neurologic neglect syndrome	61.49	15.14	52	155486	2669	63330815
Blood pressure decreased	61.35	15.14	42	155496	64980	63268504
Rebound psoriasis	60.50	15.14	19	155519	101	63333383
Leukopenia	60.45	15.14	60	155478	77230	63256254
Carotid artery thrombosis	60.29	15.14	52	155486	2742	63330742
Cholestasis	59.59	15.14	3	155535	29431	63304053
Night sweats	59.26	15.14	257	155281	48557	63284927
Pustule	59.25	15.14	42	155496	1657	63331827
Orthostatic hypotension	59.03	15.14	9	155529	36151	63297333
Adverse drug reaction	58.66	15.14	365	155173	79349	63254135
Thrombosis	58.25	15.14	44	155494	64711	63268773
Renal impairment	57.89	15.14	79	155459	88276	63245208
Pain of skin	57.85	15.14	103	155435	11531	63321953
Sinus congestion	57.34	15.14	133	155405	17990	63315494
Blood potassium decreased	57.19	15.14	16	155522	42010	63291474
Hypervolaemia	57.19	15.14	3	155535	28410	63305074
Dyskinesia	57.00	15.14	6	155532	31996	63301488
Pulmonary hypertension	56.73	15.14	11	155527	37112	63296372
Full blood count abnormal	56.35	15.14	6	155532	31711	63301773
Bone marrow failure	56.22	15.14	4	155534	29286	63304198
Asthenia	56.14	15.14	635	154903	382969	62950515
Liver function test abnormal	55.83	15.14	24	155514	48157	63285327
Peripheral swelling	55.63	15.14	938	154600	265004	63068480
Blood pressure fluctuation	55.41	15.14	22	155516	46295	63287189
Acute respiratory failure	55.35	15.14	9	155529	34476	63299008
Rash maculo-papular	54.27	15.14	7	155531	31889	63301595
Nail psoriasis	54.24	15.14	28	155510	613	63332871
Oral candidiasis	54.07	15.14	150	155388	22648	63310836
Product distribution issue	54.05	15.14	37	155501	1379	63332105
Chronic kidney disease	53.59	15.14	22	155516	45376	63288108
Melaena	53.30	15.14	6	155532	30359	63303125
Genital candidiasis	53.26	15.14	19	155519	158	63333326
Urticaria	52.86	15.14	630	154908	165172	63168312
Pericardial effusion	52.61	15.14	6	155532	30052	63303432
Disorientation	51.90	15.14	16	155522	39436	63294048
Myocardial infarction	51.79	15.14	104	155434	99789	63233695
Full blood count decreased	51.60	15.14	3	155535	26021	63307463
Axial spondyloarthritis	51.46	15.14	23	155515	361	63333123
General physical health deterioration	50.72	15.14	733	154805	200669	63132815
Lymphocyte count decreased	50.62	15.14	7	155531	30250	63303234
Cutaneous T-cell lymphoma	50.19	15.14	35	155503	1345	63332139
Skin burning sensation	50.05	15.14	102	155436	12632	63320852
Presyncope	50.03	15.14	5	155533	27780	63305704
Haematocrit decreased	49.90	15.14	17	155521	39323	63294161
Lower respiratory tract infection viral	49.88	15.14	30	155508	891	63332593
Lower respiratory tract infection	49.58	15.14	519	155019	131788	63201696
Lupus vulgaris	49.39	15.14	67	155471	5927	63327557
Hepatic cirrhosis	49.34	15.14	153	155385	24581	63308903
Alanine aminotransferase abnormal	49.29	15.14	58	155480	4446	63329038
Hepatotoxicity	48.76	15.14	15	155523	37026	63296458
Nail disorder	48.51	15.14	102	155436	12913	63320571
Urinary retention	48.43	15.14	8	155530	30293	63303191
Hypophagia	48.32	15.14	9	155529	31250	63302234
Respiratory tract congestion	48.03	15.14	123	155415	17709	63315775
Obesity	47.93	15.14	172	155366	29780	63303704
Hypermobility syndrome	47.69	15.14	28	155510	795	63332689
Disturbance in attention	47.59	15.14	17	155521	38172	63295312
Spondylitis	47.53	15.14	56	155482	4298	63329186
Seborrhoeic keratosis	47.35	15.14	42	155496	2300	63331184
Blood alkaline phosphatase increased	47.30	15.14	23	155515	42944	63290540
Hypomagnesaemia	47.26	15.14	7	155531	28730	63304754
C-reactive protein	47.13	15.14	59	155479	4823	63328661
Toxic epidermal necrolysis	47.11	15.14	4	155534	25330	63308154
Altered state of consciousness	46.87	15.14	4	155534	25226	63308258
Device leakage	46.30	15.14	71	155467	7025	63326459
Sacroiliitis	46.11	15.14	48	155490	3209	63330275
Dry skin	46.01	15.14	267	155271	56620	63276864
Hidradenitis	45.89	15.14	45	155493	2801	63330683
Sciatica	45.78	15.14	186	155352	34138	63299346
Spondyloarthropathy	45.75	15.14	28	155510	859	63332625
Off label use	45.70	15.14	1281	154257	673181	62660303
Oedema peripheral	45.37	15.14	275	155263	189236	63144248
Psychotic disorder	45.33	15.14	5	155533	25707	63307777
Limb discomfort	45.32	15.14	168	155370	29548	63303936
Device dislocation	45.32	15.14	5	155533	25700	63307784
Fluid retention	44.78	15.14	48	155490	59638	63273846
Blood calcium decreased	44.54	15.14	6	155532	26445	63307039
Hepatocellular injury	44.27	15.14	7	155531	27374	63306110
Premature delivery	44.16	15.14	10	155528	30271	63303213
Vision blurred	44.07	15.14	100	155438	91824	63241660
Pancreatitis acute	43.80	15.14	7	155531	27159	63306325
Pneumonia aspiration	43.68	15.14	15	155523	34525	63298959
Stevens-Johnson syndrome	43.62	15.14	5	155533	24945	63308539
Vulvovaginal candidiasis	43.54	15.14	46	155492	3129	63330355
Flushing	43.52	15.14	73	155465	75014	63258470
Adjustment disorder	43.50	15.14	46	155492	3132	63330352
Transient ischaemic attack	43.44	15.14	19	155519	37734	63295750
Folliculitis	43.29	15.14	308	155230	70009	63263475
Myalgia	43.25	15.14	198	155340	146331	63187153
Blood pressure increased	43.21	15.14	227	155311	161835	63171649
Movement disorder	43.21	15.14	134	155404	21527	63311957
Ascites	43.05	15.14	23	155515	40705	63292779
Breast cancer stage III	42.98	15.14	85	155453	10301	63323183
Shock	42.83	15.14	4	155534	23459	63310025
Urinary incontinence	42.08	15.14	13	155525	32001	63301483
Device delivery system issue	41.52	15.14	25	155513	744	63332740
Neck pain	41.16	15.14	301	155237	69017	63264467
Blood glucose increased	41.06	15.14	90	155448	83666	63249818
Acute myocardial infarction	40.54	15.14	14	155524	32110	63301374
Pneumonitis	40.09	15.14	18	155520	35204	63298280
Blood urea increased	39.92	15.14	8	155530	26371	63307113
Intestinal obstruction	39.81	15.14	13	155525	30886	63302598
Sinus tachycardia	39.70	15.14	6	155532	24262	63309222
Hypothyroidism	39.60	15.14	28	155510	42604	63290880
Aspartate aminotransferase increased	39.50	15.14	103	155435	90174	63243310
Cerebral haemorrhage	39.46	15.14	13	155525	30716	63302768
Premature baby	39.32	15.14	3	155535	20732	63312752
Scab	38.95	15.14	69	155469	7694	63325790
Eosinophilia	38.70	15.14	5	155533	22751	63310733
Injection site erythema	38.65	15.14	92	155446	83082	63250402
Atelectasis	38.33	15.14	4	155534	21479	63312005
Therapeutic product ineffective	38.28	15.14	33	155505	1739	63331745
Arrhythmia	38.21	15.14	23	155515	38117	63295367
Tenderness	38.15	15.14	132	155406	22446	63311038
Aggression	38.01	15.14	6	155532	23492	63309992
Dysgeusia	37.99	15.14	35	155503	46675	63286809
Spinal pain	37.87	15.14	93	155445	13046	63320438
Withdrawal syndrome	37.62	15.14	3	155535	19994	63313490
Ventricular tachycardia	37.58	15.14	3	155535	19976	63313508
Tubulointerstitial nephritis	37.40	15.14	3	155535	19900	63313584
Pain in jaw	37.30	15.14	31	155507	43465	63290019
Stress	37.25	15.14	287	155251	66880	63266604
Cytomegalovirus infection	37.13	15.14	4	155534	20948	63312536
Haematemesis	37.11	15.14	14	155524	30398	63303086
Gastrooesophageal reflux disease	36.80	15.14	116	155422	95523	63237961
Jaundice	36.48	15.14	13	155525	29238	63304246
Hepatic enzyme increased	36.39	15.14	697	154841	201631	63131853
Product dispensing error	36.38	15.14	79	155459	10226	63323258
Haematoma	36.31	15.14	20	155518	34800	63298684
Spinal fusion surgery	36.28	15.14	56	155482	5572	63327912
Wheezing	36.27	15.14	376	155162	95219	63238265
Lower limb fracture	36.16	15.14	136	155402	24085	63309399
Adverse event	35.99	15.14	286	155252	67273	63266211
Acute respiratory distress syndrome	35.90	15.14	7	155531	23527	63309957
Sneezing	35.69	15.14	112	155426	18106	63315378
Blood sodium decreased	35.38	15.14	8	155530	24244	63309240
Blood lactate dehydrogenase increased	35.00	15.14	7	155531	23109	63310375
Condition aggravated	34.89	15.14	1258	154280	400959	62932525
Secretion discharge	34.65	15.14	86	155452	12145	63321339
SARS-CoV-2 test positive	34.63	15.14	67	155471	7989	63325495
Femur fracture	34.30	15.14	31	155507	41725	63291759
Transaminases increased	34.21	15.14	17	155521	31350	63302134
Metastases to liver	34.08	15.14	8	155530	23631	63309853
Mitral valve incompetence	34.07	15.14	4	155534	19590	63313894
Coagulopathy	33.79	15.14	5	155533	20539	63312945
Symptom recurrence	33.72	15.14	31	155507	1779	63331705
Intentional product use issue	33.59	15.14	469	155069	127423	63206061
Device related infection	33.56	15.14	8	155530	23384	63310100
Dysstasia	33.40	15.14	121	155417	21045	63312439
Respiratory distress	33.28	15.14	21	155517	33930	63299554
Fungal infection	33.09	15.14	178	155360	36696	63296788
Electrolyte imbalance	32.76	15.14	5	155533	20071	63313413
Cerebral infarction	32.69	15.14	9	155529	23884	63309600
Tinnitus	32.31	15.14	24	155514	35604	63297880
Personality disorder	32.23	15.14	54	155484	5757	63327727
Exposure via partner	32.05	15.14	12	155526	116	63333368
Device dispensing error	32.05	15.14	12	155526	116	63333368
Confusional state	31.94	15.14	398	155140	235982	63097502
Muscle twitching	31.86	15.14	5	155533	19663	63313821
Coronary artery disease	31.78	15.14	20	155518	32357	63301127
Dermatitis psoriasiform	31.46	15.14	33	155505	2226	63331258
Abnormal behaviour	31.39	15.14	7	155531	21419	63312065
Alanine aminotransferase increased	31.35	15.14	139	155399	103631	63229853
Oral lichen planus	31.21	15.14	20	155518	666	63332818
Irritable bowel syndrome	31.19	15.14	324	155214	82088	63251396
Gamma-glutamyltransferase increased	30.76	15.14	23	155515	34008	63299476
Rash pustular	30.62	15.14	60	155478	7222	63326262
Psoriasis area severity index increased	30.55	15.14	10	155528	62	63333422
Hyperhidrosis	30.47	15.14	148	155390	107688	63225796
Heart rate increased	30.46	15.14	123	155415	94115	63239369
Cardiogenic shock	30.35	15.14	4	155534	17928	63315556
Hypoaesthesia	30.24	15.14	580	154958	167813	63165671
Myelodysplastic syndrome	30.20	15.14	3	155535	16751	63316733
Chronic obstructive pulmonary disease	30.20	15.14	68	155470	62618	63270866
Macular degeneration	30.12	15.14	11	155527	24365	63309119
Blood creatinine increased	30.09	15.14	112	155426	87732	63245752
Infected dermal cyst	30.02	15.14	17	155521	450	63333034
Hepatic failure	29.86	15.14	26	155512	35630	63297854
Foot deformity	29.59	15.14	141	155397	27712	63305772
Rash	29.50	15.14	1667	153871	559204	62774280
Cystitis	29.40	15.14	233	155305	54758	63278726
HLA-B*27 positive	29.26	15.14	13	155525	201	63333283
Product dose omission issue	29.14	15.14	766	154772	233547	63099937
Acute hepatic failure	28.93	15.14	5	155533	18322	63315162
Bronchiectasis	28.81	15.14	3	155535	16139	63317345
Circulatory collapse	28.67	15.14	9	155529	21929	63311555
Oedema	28.52	15.14	365	155173	97257	63236227
Product substitution issue	28.48	15.14	3	155535	15993	63317491
Parakeratosis	28.22	15.14	14	155524	281	63333203
Myoclonus	28.19	15.14	3	155535	15865	63317619
Tooth disorder	28.18	15.14	17	155521	28140	63305344
Hospitalisation	28.16	15.14	110	155428	84971	63248513
Pancreatitis	28.14	15.14	48	155490	49007	63284477
Onychomadesis	28.14	15.14	51	155487	5789	63327695
Rectal haemorrhage	28.10	15.14	48	155490	48982	63284502
Obstructive airways disorder	27.94	15.14	8	155530	20691	63312793
Heart rate irregular	27.90	15.14	10	155528	22411	63311073
Tongue disorder	27.49	15.14	72	155466	10508	63322976
Cardiomyopathy	27.32	15.14	5	155533	17579	63315905
Drug resistance	27.25	15.14	11	155527	22922	63310562
Drug ineffective for unapproved indication	27.14	15.14	26	155512	34037	63299447
Unevaluable event	27.05	15.14	53	155485	51333	63282151
Lip ulceration	26.87	15.14	29	155509	2021	63331463
Metastases to bone	26.80	15.14	9	155529	21010	63312474
Transfusion	26.72	15.14	3	155535	15214	63318270
Ataxia	26.67	15.14	3	155535	15192	63318292
Liver function test increased	26.53	15.14	154	155384	32657	63300827
Underdose	26.33	15.14	135	155403	27321	63306163
Scratch	26.29	15.14	53	155485	6512	63326972
X-ray abnormal	26.19	15.14	60	155478	8050	63325434
Complication associated with device	26.01	15.14	5	155533	16973	63316511
Cyanosis	25.91	15.14	5	155533	16930	63316554
Laboratory test abnormal	25.90	15.14	17	155521	26895	63306589
Walking aid user	25.89	15.14	71	155467	10646	63322838
Gastrointestinal pain	25.88	15.14	67	155471	9709	63323775
Pneumocystis jirovecii pneumonia	25.87	15.14	5	155533	16909	63316575
Chronic disease	25.81	15.14	11	155527	153	63333331
Tendon pain	25.64	15.14	36	155502	3290	63330194
Weight increased	25.63	15.14	467	155071	260325	63073159
Bone lesion	25.39	15.14	49	155489	5832	63327652
Cardiac murmur	25.23	15.14	3	155535	14549	63318935
Visual acuity reduced	25.08	15.14	11	155527	21815	63311669
Haemorrhage	24.91	15.14	72	155466	60950	63272534
Lymphopenia	24.89	15.14	7	155531	18320	63315164
Granuloma	24.87	15.14	48	155490	5713	63327771
Anxiety	24.83	15.14	379	155159	217162	63116322
Proteinuria	24.76	15.14	8	155530	19137	63314347
Pyoderma gangrenosum	24.68	15.14	37	155501	3588	63329896
Erythema	24.65	15.14	584	154954	175167	63158317
Road traffic accident	24.64	15.14	164	155374	36468	63297016
Live birth	24.56	15.14	126	155412	25504	63307980
Ejection fraction decreased	24.51	15.14	12	155526	22320	63311164
Rhesus antigen positive	24.49	15.14	10	155528	124	63333360
Injection site pain	24.30	15.14	450	155088	129350	63204134
Osteonecrosis	24.28	15.14	15	155523	24515	63308969
Palmoplantar pustulosis	23.45	15.14	15	155523	498	63332986
Cardiomegaly	23.42	15.14	7	155531	17607	63315877
Ileus	23.28	15.14	4	155534	14721	63318763
Respiratory rate increased	23.21	15.14	3	155535	13645	63319839
Retching	23.11	15.14	4	155534	14641	63318843
Hyperadrenocorticism	23.10	15.14	13	155525	340	63333144
Chest discomfort	23.06	15.14	166	155372	109803	63223681
Tricuspid valve incompetence	23.05	15.14	4	155534	14617	63318867
Hepatitis	22.76	15.14	39	155499	39749	63293735
Lung infiltration	22.71	15.14	4	155534	14459	63319025
Weight decreased	22.62	15.14	511	155027	276287	63057197
Seborrhoeic dermatitis	22.46	15.14	20	155518	1101	63332383
Palpitations	22.33	15.14	173	155365	112597	63220887
Kidney infection	22.25	15.14	114	155424	23062	63310422
Lichen planus	22.16	15.14	28	155510	2310	63331174
Colitis ulcerative	22.10	15.14	124	155414	25967	63307517
Urticarial vasculitis	21.88	15.14	16	155522	663	63332821
Erysipelas	21.78	15.14	55	155483	7850	63325634
Skin swelling	21.71	15.14	34	155504	3425	63330059
Nasal crusting	21.67	15.14	12	155526	304	63333180
Leukocytosis	21.61	15.14	19	155519	25916	63307568
Drug dependence	21.55	15.14	17	155521	24466	63309018
Iron deficiency anaemia	21.51	15.14	11	155527	19958	63313526
Anosmia	21.32	15.14	50	155488	6810	63326674
Pyrexia	21.29	15.14	939	154599	469539	62863945
Bacteraemia	21.14	15.14	8	155530	17340	63316144
Induration	21.13	15.14	21	155517	1329	63332155
Papulopustular rosacea	21.11	15.14	6	155532	21	63333463
Dizziness	20.93	15.14	851	154687	429074	62904410
Polyneuropathy	20.91	15.14	5	155533	14584	63318900
Blood parathyroid hormone decreased	20.87	15.14	62	155476	9729	63323755
Hemiplegia	20.80	15.14	60	155478	9263	63324221
Eczema	20.78	15.14	143	155395	32148	63301336
Upper respiratory tract infection	20.77	15.14	299	155239	81748	63251736
Peritonitis	20.76	15.14	8	155530	17146	63316338
Premature labour	20.67	15.14	3	155535	12501	63320983
Genital cyst	20.66	15.14	7	155531	49	63333435
Oral lichenoid reaction	20.53	15.14	8	155530	87	63333397
Panniculitis	20.50	15.14	68	155470	11317	63322167
Blood glucose decreased	20.48	15.14	13	155525	20939	63312545
Mania	20.36	15.14	3	155535	12364	63321120
Subdural haematoma	20.36	15.14	5	155533	14323	63319161
Candida infection	20.33	15.14	129	155409	28222	63305262
Hiatus hernia	20.30	15.14	14	155524	21580	63311904
Injection site warmth	20.28	15.14	6	155532	15189	63318295
Gait disturbance	20.27	15.14	590	154948	182588	63150896
Urosepsis	20.26	15.14	10	155528	18514	63314970
Diplopia	20.23	15.14	17	155521	23711	63309773
Renal disorder	20.10	15.14	31	155507	32943	63300541
Blood magnesium decreased	19.98	15.14	4	155534	13194	63320290
Vulval cancer stage III	19.95	15.14	5	155533	9	63333475
Collagen-vascular disease	19.83	15.14	8	155530	96	63333388
Tinea pedis	19.80	15.14	21	155517	1435	63332049
Meningitis streptococcal	19.76	15.14	9	155529	148	63333336
Skin laceration	19.70	15.14	16	155522	22692	63310792
Blood pressure diastolic decreased	19.69	15.14	16	155522	22690	63310794
Hip fracture	19.66	15.14	26	155512	29448	63304036
Impetigo	19.35	15.14	20	155518	1326	63332158
Hyperlipidaemia	19.33	15.14	12	155526	19559	63313925
Injection site laceration	19.33	15.14	8	155530	103	63333381
Dementia	19.30	15.14	11	155527	18783	63314701
Cholelithiasis	19.30	15.14	50	155488	43875	63289609
Renal tubular necrosis	19.29	15.14	3	155535	11875	63321609
Pharyngitis	19.28	15.14	99	155439	20044	63313440
Skin irritation	19.19	15.14	60	155478	9681	63323803
Product label confusion	19.17	15.14	23	155515	1799	63331685
Abscess sweat gland	18.98	15.14	5	155533	12	63333472
Hepatic cytolysis	18.95	15.14	7	155531	15400	63318084
Lethargy	18.79	15.14	72	155466	55935	63277549
Pelvic fracture	18.31	15.14	5	155533	13343	63320141
Sensory loss	18.30	15.14	61	155477	10177	63323307
Skin discomfort	18.30	15.14	14	155524	622	63332862
Loose body in joint	18.29	15.14	19	155519	1267	63332217
Motor dysfunction	18.25	15.14	63	155475	10698	63322786
Irritability	18.19	15.14	31	155507	31663	63301821
Erythematotelangiectatic rosacea	18.18	15.14	5	155533	15	63333469
Muscle spasms	18.16	15.14	271	155267	155879	63177605
Bronchospasm	17.91	15.14	10	155528	17270	63316214
Pseudomonas infection	17.83	15.14	3	155535	11210	63322274
Metastases to central nervous system	17.81	15.14	5	155533	13100	63320384
Peripheral coldness	17.77	15.14	4	155534	12161	63321323
Ischaemic stroke	17.75	15.14	11	155527	17946	63315538
Joint ankylosis	17.73	15.14	17	155521	1029	63332455
Petechiae	17.63	15.14	6	155532	13891	63319593
Abdominal distension	17.55	15.14	132	155406	86483	63247001
Tooth abscess	17.54	15.14	78	155460	14891	63318593
Multiple-drug resistance	17.53	15.14	39	155499	5131	63328353
Toxic skin eruption	17.36	15.14	5	155533	12880	63320604
Ear injury	17.35	15.14	9	155529	199	63333285
Manufacturing product shipping issue	17.35	15.14	7	155531	84	63333400
Near death experience	17.35	15.14	12	155526	455	63333029
Nightmare	17.31	15.14	13	155525	19181	63314303
Myocardial ischaemia	17.30	15.14	5	155533	12854	63320630
Metastases to lung	17.08	15.14	5	155533	12745	63320739
Drug-device interaction	16.99	15.14	7	155531	89	63333395
Impaired work ability	16.87	15.14	11	155527	17464	63316020
Oropharyngeal candidiasis	16.87	15.14	17	155521	1094	63332390
Product leakage	16.84	15.14	15	155523	826	63332658
Groin infection	16.81	15.14	11	155527	380	63333104
Diabetes mellitus inadequate control	16.80	15.14	8	155530	15118	63318366
Musculoskeletal deformity	16.74	15.14	22	155516	1887	63331597
Cellulitis	16.70	15.14	288	155250	81670	63251814
Anuria	16.67	15.14	5	155533	12546	63320938
Vaginal haemorrhage	16.60	15.14	26	155512	27461	63306023
Cytopenia	16.58	15.14	4	155534	11597	63321887
Haemophagocytic lymphohistiocytosis	16.55	15.14	3	155535	10624	63322860
Neutrophil count increased	16.51	15.14	10	155528	16517	63316967
Decubitus ulcer	16.32	15.14	3	155535	10517	63322967
Diarrhoea haemorrhagic	16.27	15.14	54	155484	8988	63324496
Food allergy	16.16	15.14	4	155534	11397	63322087
Affect lability	16.14	15.14	62	155476	11089	63322395
Dialysis	16.12	15.14	3	155535	10424	63323060
Creatinine renal clearance decreased	16.10	15.14	10	155528	16298	63317186
Pregnancy on contraceptive	15.87	15.14	17	155521	1175	63332309
Small intestinal obstruction	15.81	15.14	13	155525	18324	63315160
Ear infection fungal	15.75	15.14	8	155530	169	63333315
Hypertensive crisis	15.62	15.14	9	155529	15277	63318207
Dandruff	15.60	15.14	9	155529	247	63333237
Poisoning	15.59	15.14	7	155531	13693	63319791
Fracture	15.54	15.14	15	155523	19569	63313915
Head injury	15.54	15.14	27	155511	27369	63306115
Actinic keratosis	15.53	15.14	25	155513	2579	63330905
Ecchymosis	15.52	15.14	4	155534	11090	63322394
Gallbladder rupture	15.47	15.14	11	155527	436	63333048
Benign laryngeal neoplasm	15.42	15.14	5	155533	30	63333454
Red cell distribution width decreased	15.40	15.14	22	155516	2043	63331441
White blood cell count increased	15.30	15.14	64	155474	48497	63284987
Cerebrovascular accident	15.29	15.14	180	155358	107844	63225640

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	1622.81	15.01	2846	57746	453905	34442434
Inappropriate schedule of product administration	1134.42	15.01	906	59686	61390	34834949
Psoriasis	1088.62	15.01	733	59859	38079	34858260
Incorrect dose administered	860.50	15.01	646	59946	39869	34856470
Arthralgia	753.94	15.01	1177	59415	168864	34727475
Device malfunction	739.23	15.01	361	60231	10060	34886279
Psoriatic arthropathy	680.08	15.01	425	60167	19373	34876966
Skin plaque	601.88	15.01	245	60347	4369	34891970
Therapeutic product effect incomplete	596.46	15.01	575	60017	49966	34846373
Pain	548.29	15.01	1138	59454	203537	34692802
Musculoskeletal stiffness	469.40	15.01	487	60105	46193	34850146
Pruritus	447.72	15.01	846	59746	141135	34755204
Device issue	368.99	15.01	223	60369	9554	34886785
Nasopharyngitis	368.39	15.01	526	60066	69442	34826897
Arthritis	368.29	15.01	356	60236	30990	34865349
Accidental exposure to product	366.00	15.01	245	60347	12557	34883782
Skin exfoliation	361.42	15.01	332	60260	27100	34869239
Incorrect dose administered by device	346.71	15.01	128	60464	1730	34894609
Acute kidney injury	344.31	15.01	58	60534	304930	34591409
Toxicity to various agents	326.42	15.01	4	60588	200358	34695981
Joint swelling	316.29	15.01	451	60141	59439	34836900
Skin lesion	244.02	15.01	242	60350	21719	34874620
Macule	241.32	15.01	93	60499	1424	34894915
Drug interaction	239.69	15.01	50	60542	225896	34670443
Treatment failure	229.47	15.01	340	60252	46357	34849982
Febrile neutropenia	221.55	15.01	3	60589	136846	34759493
Anaemia	214.36	15.01	69	60523	233266	34663073
Uveitis	210.04	15.01	142	60450	7393	34888946
Hypotension	195.83	15.01	70	60522	221579	34674760
Therapeutic product effect decreased	191.20	15.01	267	60325	34476	34861863
Pain in extremity	190.02	15.01	565	60027	125948	34770391
Product dose omission issue	182.02	15.01	537	60055	119174	34777165
Neutropenia	171.77	15.01	32	60560	156746	34739593
Ankylosing spondylitis	171.64	15.01	112	60480	5492	34890847
Inflammation	167.06	15.01	225	60367	28070	34868269
Neck pain	165.82	15.01	212	60380	25137	34871202
Thrombocytopenia	164.67	15.01	35	60557	156212	34740127
Decreased immune responsiveness	152.98	15.01	69	60523	1595	34894744
Therapy interrupted	143.06	15.01	146	60446	13551	34882788
Device defective	140.07	15.01	52	60540	714	34895625
Erythema	139.38	15.01	403	60189	88377	34807962
Erysipelas	138.77	15.01	93	60499	4770	34891569
Injection site haemorrhage	137.94	15.01	123	60469	9645	34886694
Completed suicide	137.92	15.01	8	60584	98160	34798179
Inflammatory bowel disease	137.71	15.01	77	60515	2843	34893496
Influenza	136.64	15.01	280	60312	49386	34846953
Therapeutic response shortened	132.83	15.01	107	60485	7297	34889042
Product storage error	132.36	15.01	111	60481	8011	34888328
Product prescribing error	124.32	15.01	175	60417	22752	34873587
Malaise	121.68	15.01	639	59953	185186	34711153
Spinal pain	120.54	15.01	92	60500	5797	34890542
COVID-19	115.92	15.01	346	60246	77204	34819135
Needle issue	114.65	15.01	91	60501	6074	34890265
Back pain	113.85	15.01	465	60127	121324	34775015
Respiratory failure	112.95	15.01	25	60567	108547	34787792
Oropharyngeal pain	110.79	15.01	211	60381	35274	34861065
Disease progression	110.20	15.01	26	60566	108051	34788288
Off label use	109.61	15.01	368	60224	419156	34477183
Sinusitis	108.69	15.01	229	60363	41173	34855166
Confusional state	106.02	15.01	59	60533	144101	34752238
Wrong technique in device usage process	106.01	15.01	52	60540	1460	34894879
Pancytopenia	105.05	15.01	19	60573	95138	34801201
Cellulitis	103.79	15.01	261	60331	52690	34843649
Platelet count decreased	101.89	15.01	40	60552	119677	34776662
Peripheral swelling	101.87	15.01	328	60264	76213	34820126
Dactylitis	100.18	15.01	43	60549	879	34895460
Pain of skin	98.53	15.01	83	60509	6026	34890313
Arthropathy	97.94	15.01	171	60421	26736	34869603
Injection site pain	96.92	15.01	211	60381	38794	34857545
Decreased appetite	96.28	15.01	88	60504	166304	34730035
Rhabdomyolysis	94.37	15.01	6	60586	68157	34828182
Constipation	93.79	15.01	61	60531	136921	34759418
Papule	89.90	15.01	67	60525	4072	34892267
Illness	89.79	15.01	114	60478	13415	34882924
Death	88.38	15.01	373	60219	397676	34498663
Hyponatraemia	88.12	15.01	18	60574	82673	34813666
Haemoglobin decreased	86.53	15.01	51	60541	120721	34775618
Vein rupture	84.34	15.01	38	60554	876	34895463
Therapy cessation	83.88	15.01	124	60468	16849	34879490
Hyperkalaemia	83.06	15.01	11	60581	69378	34826961
Lower respiratory tract infection	83.03	15.01	175	60417	31462	34864877
Scab	82.93	15.01	67	60525	4587	34891752
Seizure	81.37	15.01	40	60552	104817	34791522
Bradycardia	81.23	15.01	16	60576	75402	34820937
Dehydration	80.95	15.01	64	60528	129905	34766434
Sacroiliitis	80.31	15.01	43	60549	1455	34894884
Overdose	79.84	15.01	29	60563	91030	34805309
Skin fissures	79.81	15.01	69	60523	5190	34891149
Joint stiffness	79.19	15.01	96	60496	10777	34885562
Infection	78.54	15.01	339	60253	90576	34805763
C-reactive protein increased	77.62	15.01	238	60354	53860	34842479
Cardiac arrest	77.19	15.01	35	60557	96124	34800215
Localised infection	76.36	15.01	121	60471	17466	34878873
Cardio-respiratory arrest	76.11	15.01	5	60587	55268	34841071
Incorrect route of product administration	75.60	15.01	110	60482	14735	34881604
Skin haemorrhage	74.30	15.01	63	60529	4615	34891724
Renal failure	73.20	15.01	71	60521	130486	34765853
White blood cell count decreased	71.67	15.01	38	60554	95407	34800932
Drug intolerance	70.12	15.01	245	60347	59325	34837014
Acne	69.91	15.01	91	60501	10975	34885364
Vomiting	69.49	15.01	210	60382	247411	34648928
Neutrophil count decreased	69.27	15.01	5	60587	51099	34845240
International normalised ratio increased	69.16	15.01	3	60589	47324	34849015
Enthesopathy	68.94	15.01	60	60532	4553	34891786
Dry skin	68.52	15.01	161	60431	31126	34865213
Oral candidiasis	67.96	15.01	94	60498	12016	34884323
Multiple organ dysfunction syndrome	67.77	15.01	24	60568	76542	34819797
Concomitant disease aggravated	67.35	15.01	65	60527	5636	34890703
Gastrointestinal haemorrhage	66.77	15.01	35	60557	88442	34807897
Nail psoriasis	66.66	15.01	18	60574	77	34896262
Synovitis	65.57	15.01	100	60492	13966	34882373
Sepsis	65.37	15.01	118	60474	166443	34729896
Joint ankylosis	64.87	15.01	38	60554	1534	34894805
Intentional product use issue	63.76	15.01	13	60579	59803	34836536
Venous injury	63.66	15.01	23	60569	291	34896048
Scratch	63.50	15.01	50	60542	3298	34893041
Therapeutic product effect delayed	63.32	15.01	35	60557	1263	34895076
Hypoxia	62.99	15.01	10	60582	55085	34841254
Septic shock	62.75	15.01	23	60569	71811	34824528
Colitis ulcerative	62.73	15.01	107	60485	16413	34879926
Product distribution issue	61.92	15.01	28	60564	651	34895688
Pleural effusion	61.91	15.01	32	60560	81514	34814825
Tachycardia	61.83	15.01	35	60557	84737	34811602
Depressed level of consciousness	61.67	15.01	3	60589	42838	34853501
Hypokalaemia	61.33	15.01	13	60579	58201	34838138
Plasma cell myeloma	60.33	15.01	3	60589	42034	34854305
Rebound psoriasis	60.02	15.01	18	60574	120	34896219
Symptom recurrence	59.16	15.01	28	60564	725	34895614
Injection site bruising	59.07	15.01	74	60518	8589	34887750
Delirium	57.67	15.01	5	60587	43986	34852353
Infusion related reaction	57.66	15.01	11	60581	53046	34843293
Intentional product misuse	57.63	15.01	6	60586	45605	34850734
Metabolic acidosis	57.17	15.01	5	60587	43675	34852664
Skin disorder	57.11	15.01	92	60500	13463	34882876
Mobility decreased	56.40	15.01	146	60446	29982	34866357
Discomfort	55.89	15.01	110	60482	18828	34877511
Epistaxis	55.55	15.01	16	60576	58235	34838104
Renal impairment	54.59	15.01	50	60542	94463	34801876
Burning sensation	54.48	15.01	107	60485	18287	34878052
Therapeutic product ineffective	54.43	15.01	27	60565	777	34895562
Dyspnoea	54.12	15.01	407	60185	376375	34519964
Hypoglycaemia	54.00	15.01	14	60578	54626	34841713
Rhinorrhoea	53.94	15.01	130	60462	25538	34870801
Ear infection	53.83	15.01	77	60515	10154	34886185
Dermatitis psoriasiform	53.54	15.01	33	60559	1463	34894876
Neuropathy peripheral	53.09	15.01	40	60552	83223	34813116
Upper respiratory tract infection	52.69	15.01	151	60441	32908	34863431
Agitation	52.51	15.01	17	60575	57382	34838957
Hallucination	51.27	15.01	13	60579	51485	34844854
Skin injury	51.01	15.01	38	60554	2307	34894032
Atrial fibrillation	50.46	15.01	84	60508	122309	34774030
Electrocardiogram QT prolonged	50.19	15.01	6	60586	40946	34855393
Suicide attempt	49.80	15.01	5	60587	39111	34857228
Swelling	49.62	15.01	174	60418	42192	34854147
Aggression	49.55	15.01	5	60587	38959	34857380
Mycobacterium tuberculosis complex test positive	49.25	15.01	30	60562	1302	34895037
Oxygen saturation decreased	49.13	15.01	16	60576	53802	34842537
Grip strength decreased	48.94	15.01	42	60550	3127	34893212
Syncope	47.54	15.01	53	60539	91398	34804941
Injection site papule	47.53	15.01	19	60573	322	34896017
Movement disorder	47.39	15.01	80	60512	12168	34884171
Blood creatine phosphokinase increased	47.28	15.01	10	60582	44847	34851492
Musculoskeletal discomfort	45.83	15.01	63	60529	8005	34888334
Fall	45.53	15.01	189	60403	202696	34693643
Asthenia	45.36	15.01	245	60347	245006	34651333
Muscle swelling	45.06	15.01	19	60573	371	34895968
Rash	44.92	15.01	586	60006	222166	34674173
Palmoplantar pustulosis	44.58	15.01	14	60578	111	34896228
Coma	44.57	15.01	12	60580	45666	34850673
Ligament calcification	44.17	15.01	16	60576	204	34896135
Latent tuberculosis	43.60	15.01	28	60564	1335	34895004
Oedema peripheral	43.38	15.01	89	60503	119723	34776616
Mental status changes	43.33	15.01	7	60585	38076	34858263
Drug reaction with eosinophilia and systemic symptoms	42.60	15.01	4	60588	33008	34863331
Pharyngitis streptococcal	42.32	15.01	36	60556	2648	34893691
Tuberculosis	41.42	15.01	62	60530	8515	34887824
Deep vein thrombosis	40.75	15.01	32	60560	65216	34831123
Pelvic pain	40.62	15.01	34	60558	2446	34893893
Pulmonary embolism	40.42	15.01	58	60534	89688	34806651
Skin infection	40.36	15.01	58	60534	7679	34888660
Skin irritation	40.21	15.01	49	60543	5528	34890811
Self-consciousness	40.02	15.01	11	60581	51	34896288
Somnolence	39.83	15.01	83	60509	111033	34785306
Loss of consciousness	39.68	15.01	51	60541	82616	34813723
Tremor	39.59	15.01	51	60541	82536	34813803
Pulmonary oedema	38.59	15.01	17	60575	47512	34848827
Lactic acidosis	38.22	15.01	7	60585	34765	34861574
Mucosal inflammation	37.96	15.01	10	60582	38612	34857727
Hepatic cirrhosis	37.79	15.01	89	60503	17225	34879114
Tenderness	37.68	15.01	53	60539	6881	34889458
Abscess limb	37.64	15.01	38	60554	3479	34892860
Respiratory distress	37.49	15.01	8	60584	35657	34860682
Blood creatinine increased	37.47	15.01	67	60525	94909	34801430
Eczema	37.27	15.01	92	60500	18344	34877995
Product dispensing error	37.17	15.01	50	60542	6224	34890115
Melaena	37.06	15.01	8	60584	35372	34860967
Cardiac failure	36.33	15.01	64	60528	91184	34805155
Cutaneous symptom	36.15	15.01	15	60577	281	34896058
Rash erythematous	35.90	15.01	110	60482	24867	34871472
Hepatic function abnormal	35.81	15.01	16	60576	44347	34851992
Oral herpes	35.63	15.01	46	60546	5501	34890838
Pneumonia aspiration	35.61	15.01	14	60578	41889	34854450
Insurance issue	35.58	15.01	29	60563	2010	34894329
Hyperglycaemia	35.57	15.01	12	60580	39468	34856871
Sensitisation	35.25	15.01	13	60579	175	34896164
Nephrolithiasis	35.01	15.01	124	60468	30209	34866130
Cough	34.98	15.01	406	60186	149734	34746605
Pneumonia	34.88	15.01	432	60160	362195	34534144
Ear infection fungal	33.62	15.01	9	60583	37	34896302
Product availability issue	33.27	15.01	27	60565	1860	34894479
Lipoma	33.21	15.01	26	60566	1700	34894639
Upper gastrointestinal haemorrhage	33.17	15.01	3	60589	25515	34870824
Encephalopathy	33.12	15.01	10	60582	35309	34861030
Spondylitis	33.04	15.01	23	60569	1255	34895084
Dyshidrotic eczema	32.92	15.01	12	60580	156	34896183
Pneumonitis	32.86	15.01	9	60583	33869	34862470
Bone cyst	32.75	15.01	25	60567	1575	34894764
Terminal insomnia	31.86	15.01	17	60575	571	34895768
Injection site swelling	31.67	15.01	65	60527	11462	34884877
Oligoarthritis	31.51	15.01	11	60581	125	34896214
Orthostatic hypotension	31.27	15.01	4	60588	25915	34870424
Hypocalcaemia	31.19	15.01	3	60589	24286	34872053
Drug dependence	31.07	15.01	3	60589	24214	34872125
Tinea versicolour	30.90	15.01	14	60578	327	34896012
Device dispensing error	30.82	15.01	9	60583	54	34896285
Medication error	30.71	15.01	4	60588	25561	34870778
Hand deformity	30.62	15.01	35	60557	3690	34892649
Cholestasis	30.55	15.01	5	60587	26943	34869396
Agranulocytosis	30.44	15.01	3	60589	23818	34872521
Secretion discharge	30.41	15.01	44	60548	5861	34890478
Onycholysis	30.12	15.01	18	60574	754	34895585
Stress	29.97	15.01	118	60474	30229	34866110
Abnormal behaviour	29.77	15.01	4	60588	24965	34871374
Cutaneous lymphoma	29.70	15.01	10	60582	101	34896238
Anti-cyclic citrullinated peptide antibody positive	29.63	15.01	25	60567	1818	34894521
Accident	29.56	15.01	40	60552	5007	34891332
Product supply issue	29.50	15.01	17	60575	665	34895674
Influenza like illness	29.38	15.01	110	60482	27524	34868815
Cytomegalovirus infection	29.30	15.01	5	60587	26130	34870209
Tooth abscess	29.26	15.01	43	60549	5810	34890529
Hidradenitis	29.22	15.01	20	60572	1062	34895277
Dermatitis exfoliative generalised	29.08	15.01	34	60558	3673	34892666
Skin burning sensation	29.04	15.01	38	60554	4605	34891734
Musculoskeletal pain	28.96	15.01	121	60471	31842	34864497
Hypersensitivity	28.89	15.01	193	60399	60842	34835497
Aspartate aminotransferase increased	28.40	15.01	46	60546	67737	34828602
Disorientation	28.35	15.01	11	60581	33177	34863162
Therapeutic response decreased	28.16	15.01	113	60479	29200	34867139
Folliculitis	27.98	15.01	37	60555	4529	34891810
Blood pressure fluctuation	27.93	15.01	5	60587	25244	34871095
Irritable bowel syndrome	27.89	15.01	33	60559	3610	34892729
Urinary retention	27.88	15.01	14	60578	36274	34860065
Ascites	27.64	15.01	24	60568	46547	34849792
Haematemesis	27.57	15.01	7	60585	27704	34868635
Hepatic steatosis	27.45	15.01	82	60510	18280	34878059
Candida infection	27.33	15.01	80	60512	17635	34878704
Angiocardiogram	27.27	15.01	11	60581	191	34896148
Nasal congestion	27.25	15.01	95	60497	22962	34873377
Body surface area increased	27.18	15.01	9	60583	86	34896253
Respiratory tract infection	26.66	15.01	85	60507	19627	34876712
Red blood cell sedimentation rate abnormal	26.64	15.01	32	60560	3557	34892782
Skin discomfort	26.57	15.01	10	60582	143	34896196
Altered state of consciousness	26.51	15.01	4	60588	22889	34873450
Malignant melanoma	26.34	15.01	49	60543	8041	34888298
Seborrhoeic keratosis	26.32	15.01	20	60572	1251	34895088
Exposure to communicable disease	26.31	15.01	10	60582	147	34896192
Shock	26.29	15.01	5	60587	24174	34872165
Blood bilirubin increased	26.24	15.01	17	60575	38279	34858060
Restlessness	26.20	15.01	6	60586	25476	34870863
Cerebral haemorrhage	26.07	15.01	14	60578	34923	34861416
Dyspnoea exertional	26.05	15.01	22	60570	43257	34853082
Inflammatory pain	26.03	15.01	11	60581	216	34896123
Tonsillitis bacterial	25.91	15.01	7	60585	30	34896309
Ventricular tachycardia	25.89	15.01	7	60585	26572	34869767
Feeling abnormal	25.86	15.01	193	60399	63042	34833297
Pustular psoriasis	25.81	15.01	22	60570	1623	34894716
Wound	25.75	15.01	70	60522	14794	34881545
Iridocyclitis	25.73	15.01	22	60570	1630	34894709
Red blood cell sedimentation rate increased	25.57	15.01	52	60540	9110	34887229
Dermatitis	25.56	15.01	53	60539	9415	34886924
Device leakage	25.50	15.01	43	60549	6532	34889807
Hypokinesia	25.50	15.01	51	60541	8829	34887510
Hepatocellular injury	25.45	15.01	4	60588	22207	34874132
Limb discomfort	25.44	15.01	58	60534	10989	34885350
Xyphoid retraction	25.37	15.01	10	60582	163	34896176
Tinea pedis	25.36	15.01	21	60571	1488	34894851
Disability	25.26	15.01	36	60556	4729	34891610
Injection site reaction	25.25	15.01	64	60528	12969	34883370
Skin discolouration	25.10	15.01	78	60514	17767	34878572
Basal cell carcinoma	24.99	15.01	83	60509	19575	34876764
Genital candidiasis	24.88	15.01	8	60584	69	34896270
Psoriasis area severity index increased	24.87	15.01	7	60585	36	34896303
Psychotic disorder	24.66	15.01	6	60586	24446	34871893
Tooth infection	24.58	15.01	43	60549	6728	34889611
Eye infection	24.44	15.01	31	60561	3642	34892697
Bursitis	24.31	15.01	38	60554	5420	34890919
Dizziness	24.21	15.01	252	60340	218269	34678070
Guttate psoriasis	24.20	15.01	11	60581	259	34896080
Interstitial lung disease	24.03	15.01	48	60544	65234	34831105
Haematuria	23.90	15.01	31	60561	50035	34846304
Hypervolaemia	23.87	15.01	3	60589	19706	34876633
Tonsillitis	23.86	15.01	25	60567	2391	34893948
Tubulointerstitial nephritis	23.61	15.01	4	60588	21020	34875319
Pigmentation disorder	23.41	15.01	25	60567	2444	34893895
Tendonitis	23.32	15.01	50	60542	9090	34887249
Drug resistance	23.14	15.01	8	60584	25919	34870420
Underdose	22.98	15.01	64	60528	13716	34882623
Lentigo	22.98	15.01	13	60579	491	34895848
Seronegative arthritis	22.97	15.01	17	60575	1022	34895317
Alanine aminotransferase abnormal	22.80	15.01	34	60558	4654	34891685
Oesophageal infection	22.78	15.01	11	60581	298	34896041
Total cholesterol/HDL ratio decreased	22.69	15.01	7	60585	52	34896287
Subdural haematoma	22.68	15.01	4	60588	20417	34875922
Nail pitting	22.58	15.01	11	60581	304	34896035
Intestinal haemorrhage	22.47	15.01	29	60563	3467	34892872
Abdominal discomfort	22.45	15.01	179	60413	59656	34836683
Body mass index abnormal	22.43	15.01	9	60583	154	34896185
Haemorrhage	22.33	15.01	34	60558	51336	34845003
Acute respiratory failure	22.20	15.01	13	60579	30915	34865424
Stevens-Johnson syndrome	22.19	15.01	3	60589	18636	34877703
Coronavirus infection	22.05	15.01	32	60560	4275	34892064
Actinic keratosis	22.03	15.01	33	60559	4534	34891805
Immune system disorder	21.93	15.01	35	60557	5080	34891259
Angioimmunoblastic T-cell lymphoma	21.81	15.01	11	60581	328	34896011
Product leakage	21.70	15.01	13	60579	547	34895792
Energy increased	21.66	15.01	18	60574	1282	34895057
Hepatic failure	21.47	15.01	17	60575	34514	34861825
Bone marrow failure	21.42	15.01	12	60580	29241	34867098
Conjunctivitis viral	21.31	15.01	7	60585	65	34896274
Gastrointestinal infection	21.28	15.01	37	60555	5761	34890578
Chronic kidney disease	21.27	15.01	24	60568	41186	34855153
Bronchitis	21.26	15.01	135	60457	41828	34854511
Onychomadesis	21.16	15.01	13	60579	573	34895766
Blood alkaline phosphatase increased	21.14	15.01	14	60578	31161	34865178
Therapy non-responder	21.12	15.01	128	60464	39018	34857321
Blood potassium decreased	21.05	15.01	3	60589	17912	34878427
Spinal disorder	20.91	15.01	31	60561	4221	34892118
Cyst	20.83	15.01	32	60560	4496	34891843
Bone erosion	20.80	15.01	30	60562	3985	34892354
Atelectasis	20.75	15.01	3	60589	17724	34878615
Pseudarthrosis	20.51	15.01	7	60585	74	34896265
Hypophagia	20.45	15.01	8	60584	24014	34872325
Hepatic fibrosis	20.41	15.01	32	60560	4575	34891764
Erythrodermic psoriasis	20.41	15.01	15	60577	892	34895447
C-reactive protein abnormal	20.36	15.01	46	60546	8664	34887675
Viral infection	20.30	15.01	72	60520	17551	34878788
Acute respiratory distress syndrome	19.98	15.01	10	60582	25959	34870380
Dyskinesia	19.86	15.01	7	60585	22406	34873933
Joint injury	19.85	15.01	47	60545	9126	34887213
Generalised tonic-clonic seizure	19.84	15.01	6	60586	21168	34875171
Hepatic mass	19.60	15.01	16	60576	1111	34895228
Tachypnoea	19.52	15.01	4	60588	18348	34877991
Pulmonary hypertension	19.48	15.01	6	60586	20918	34875421
Premature baby	19.45	15.01	5	60587	19628	34876711
Acute myeloid leukaemia	19.40	15.01	4	60588	18266	34878073
Kidney infection	19.25	15.01	34	60558	5360	34890979
Gastrointestinal pain	19.13	15.01	27	60565	3515	34892824
Diabetes mellitus	19.12	15.01	143	60449	46730	34849609
Ocular hyperaemia	18.91	15.01	53	60539	11399	34884940
Fear of injection	18.91	15.01	18	60574	1534	34894805
Eosinophilia	18.86	15.01	11	60581	26211	34870128
Gait disturbance	18.81	15.01	228	60364	84912	34811427
Rosacea	18.81	15.01	16	60576	1177	34895162
Oral pustule	18.70	15.01	9	60583	242	34896097
Nausea	18.62	15.01	448	60144	339460	34556879
Balance disorder	18.56	15.01	26	60566	40628	34855711
Osteolysis	18.51	15.01	25	60567	3123	34893216
Skin ulcer	18.50	15.01	82	60510	22134	34874205
Disturbance in attention	18.49	15.01	11	60581	25934	34870405
Diarrhoea haemorrhagic	18.42	15.01	38	60554	6726	34889613
Staphylococcal skin infection	18.37	15.01	14	60578	880	34895459
Arrhythmia	18.32	15.01	21	60571	35787	34860552
General physical health deterioration	18.10	15.01	139	60453	128130	34768209
Haematoma	18.05	15.01	11	60581	25594	34870745
Ear pruritus	17.98	15.01	10	60582	365	34895974
Carbon dioxide abnormal	17.85	15.01	8	60584	182	34896157
Osteoarthritis	17.81	15.01	77	60515	20565	34875774
Leukopenia	17.78	15.01	53	60539	62803	34833536
Flushing	17.72	15.01	18	60574	32402	34863937
Rash maculo-papular	17.70	15.01	14	60578	28437	34867902
Skin papilloma	17.69	15.01	20	60572	2083	34894256
Stomatitis	17.66	15.01	29	60563	42485	34853854
Renal tubular necrosis	17.57	15.01	3	60589	15677	34880662
Blood lactate dehydrogenase increased	17.47	15.01	9	60583	22981	34873358
Spondyloarthropathy	17.43	15.01	12	60580	643	34895696
Wheezing	17.43	15.01	28	60564	41374	34854965
Coronary artery disease	17.36	15.01	36	60556	48269	34848070
Dry mouth	17.35	15.01	16	60576	30149	34866190
Obstructive airways disorder	17.29	15.01	3	60589	15491	34880848
Chronic obstructive pulmonary disease	17.13	15.01	37	60555	48881	34847458
Pneumothorax	16.85	15.01	6	60586	19086	34877253
Ear neoplasm	16.82	15.01	6	60586	73	34896266
Hospitalisation	16.81	15.01	47	60545	56855	34839484
Eye discharge	16.75	15.01	19	60573	1987	34894352
Pustule	16.73	15.01	11	60581	546	34895793
Ulcer	16.72	15.01	43	60549	8792	34887547
Undifferentiated connective tissue disease	16.71	15.01	5	60587	33	34896306
Post infection glomerulonephritis	16.60	15.01	6	60586	76	34896263
Dysgeusia	16.53	15.01	13	60579	26484	34869855
Lower respiratory tract congestion	16.43	15.01	15	60577	1212	34895127
Blood urea increased	16.43	15.01	17	60575	30347	34865992
Injection site paraesthesia	16.40	15.01	7	60585	141	34896198
Pyoderma gangrenosum	16.31	15.01	16	60576	1415	34894924
Dandruff	16.26	15.01	8	60584	226	34896113
Sinus tachycardia	16.12	15.01	5	60587	17355	34878984
Nasal abscess	16.08	15.01	3	60589	0	34896339
Administration site haemorrhage	16.08	15.01	3	60589	0	34896339
Hepatic encephalopathy	16.04	15.01	3	60589	14682	34881657
Diverticulitis	16.03	15.01	73	60519	19931	34876408
Melanocytic naevus	15.94	15.01	20	60572	2324	34894015
Bursitis infective	15.94	15.01	11	60581	592	34895747
Xerosis	15.92	15.01	11	60581	593	34895746
Cutaneous sarcoidosis	15.92	15.01	7	60585	152	34896187
Scrotal cancer	15.91	15.01	4	60588	12	34896327
Anaphylactic shock	15.91	15.01	4	60588	15937	34880402
Furuncle	15.82	15.01	24	60568	3334	34893005
Fibromyalgia	15.82	15.01	23	60569	3077	34893262
Feeling hot	15.76	15.01	71	60521	19301	34877038
Skin lesion inflammation	15.67	15.01	4	60588	13	34896326
Skin candida	15.62	15.01	10	60582	474	34895865
Coronavirus test positive	15.51	15.01	10	60582	480	34895859
Laboratory test abnormal	15.47	15.01	8	60584	20383	34875956
Cardiomyopathy	15.33	15.01	5	60587	16803	34879536
Granuloma annulare	15.28	15.01	7	60585	168	34896171
Borrelia infection	15.27	15.01	5	60587	46	34896293
Nail dystrophy	15.21	15.01	8	60584	261	34896078
Axillary pain	15.13	15.01	9	60583	374	34895965
Joint effusion	15.12	15.01	30	60562	5163	34891176
Liver function test abnormal	15.07	15.01	19	60573	31055	34865284
Adrenal insufficiency	15.07	15.01	3	60589	14044	34882295

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Inappropriate schedule of product administration	1194.32	14.91	1372	151012	132256	79459748
Psoriasis	1037.29	14.91	1055	151329	88532	79503472
Musculoskeletal stiffness	897.04	14.91	1368	151016	173640	79418364
Psoriatic arthropathy	881.86	14.91	907	151477	77092	79514912
Drug ineffective	806.48	14.91	4123	148261	1076790	78515214
Therapy interrupted	763.77	14.91	565	151819	30776	79561228
Acute kidney injury	739.71	14.91	70	152314	519334	79072670
Toxicity to various agents	732.83	14.91	15	152369	421525	79170479
Arthralgia	651.75	14.91	2480	149904	569323	79022681
Drug interaction	540.81	14.91	76	152308	415107	79176897
Nasopharyngitis	527.48	14.91	1358	151026	252523	79339481
Skin plaque	514.61	14.91	296	152088	10449	79581555
Hypotension	493.33	14.91	118	152266	440199	79151805
Pain	484.23	14.91	2630	149754	701172	78890832
Anaemia	477.93	14.91	130	152254	444885	79147119
Therapeutic product effect incomplete	442.51	14.91	891	151493	140754	79451250
Joint swelling	442.15	14.91	1383	151001	287263	79304741
Completed suicide	438.18	14.91	6	152378	245761	79346243
Incorrect dose administered	426.27	14.91	623	151761	76007	79515997
Febrile neutropenia	424.08	14.91	3	152381	230996	79361008
Neutropenia	405.82	14.91	40	152344	287670	79304334
Arthritis	386.99	14.91	746	151638	114134	79477870
Treatment failure	342.44	14.91	901	151483	169585	79422419
Thrombocytopenia	339.45	14.91	51	152333	265208	79326796
Therapeutic product effect decreased	327.06	14.91	864	151520	162999	79429005
Synovitis	317.47	14.91	811	151573	149923	79442081
Death	315.93	14.91	371	152013	566143	79025861
Skin exfoliation	304.96	14.91	447	151937	54653	79537351
Inflammation	303.74	14.91	599	151785	93154	79498850
Wound	287.21	14.91	665	151719	115514	79476490
Fibromyalgia	286.29	14.91	472	151912	63868	79528136
Liver injury	280.24	14.91	436	151948	56178	79535826
Malaise	271.30	14.91	1731	150653	488138	79103866
Discomfort	270.84	14.91	682	151702	124935	79467069
Rheumatic fever	269.76	14.91	302	152082	28223	79563781
Hyponatraemia	257.96	14.91	22	152362	177826	79414178
Skin lesion	257.36	14.91	357	152027	41487	79550517
Pruritus	252.35	14.91	1448	150936	393200	79198804
Arthropathy	252.01	14.91	828	151556	176283	79415721
Mobility decreased	251.65	14.91	652	151732	121523	79470481
Infection	248.61	14.91	1017	151367	240695	79351309
Influenza	247.04	14.91	672	151712	128934	79463070
Constipation	246.88	14.91	116	152268	282934	79309070
Malignant neoplasm progression	239.38	14.91	4	152380	135986	79456018
Enthesopathy	238.20	14.91	189	152195	11419	79580585
Swollen joint count increased	234.59	14.91	253	152131	22674	79569330
Hand deformity	234.31	14.91	574	151810	103345	79488659
Pemphigus	231.96	14.91	557	151827	99025	79492979
Drug intolerance	231.55	14.91	1059	151325	263060	79328944
Platelet count decreased	230.18	14.91	46	152338	194618	79397386
COVID-19	229.57	14.91	743	151641	156931	79435073
Glossodynia	228.98	14.91	567	151817	102770	79489234
Type 2 diabetes mellitus	228.91	14.91	400	151984	56722	79535282
Respiratory failure	226.33	14.91	37	152347	180874	79411130
Pain in extremity	222.24	14.91	1321	151063	363217	79228787
Disease progression	217.08	14.91	44	152340	184318	79407686
Pancytopenia	216.29	14.91	30	152354	165715	79426289
Systemic lupus erythematosus	209.11	14.91	606	151778	120543	79471461
Oropharyngeal pain	207.37	14.91	566	151818	108787	79483217
Bradycardia	204.38	14.91	14	152370	135543	79456461
Haemoglobin decreased	203.14	14.91	85	152299	222034	79369970
Anti-cyclic citrullinated peptide antibody positive	202.23	14.91	473	151911	82670	79509334
Pericarditis	202.14	14.91	544	151840	103692	79488312
Cardiac arrest	200.70	14.91	42	152342	172054	79419950
Device malfunction	195.85	14.91	223	152161	21225	79570779
Rheumatoid factor positive	190.93	14.91	380	152004	59459	79532545
Hypokalaemia	190.48	14.91	25	152359	144015	79447989
C-reactive protein increased	190.48	14.91	611	151773	128416	79463588
White blood cell count decreased	187.32	14.91	63	152321	188225	79403779
Dehydration	187.03	14.91	122	152262	248065	79343939
Illness	184.15	14.91	324	152060	46187	79545817
Abdominal discomfort	182.21	14.91	953	151431	249774	79342230
Grip strength decreased	180.70	14.91	216	152168	21653	79570351
Rheumatoid arthritis	178.98	14.91	831	151553	207639	79384365
Seronegative arthritis	177.29	14.91	111	152273	4581	79587423
Renal failure	177.28	14.91	81	152303	200887	79391117
Ear infection	177.14	14.91	270	152114	34162	79557842
Skin haemorrhage	175.99	14.91	161	152223	11820	79580184
Dislocation of vertebra	174.02	14.91	134	152250	7746	79584258
Duodenal ulcer perforation	173.53	14.91	388	151996	65823	79526181
Rhabdomyolysis	170.24	14.91	6	152378	103125	79488879
Somnolence	167.50	14.91	127	152257	238854	79353150
Prescribed overdose	167.25	14.91	277	152107	37606	79554398
Cardio-respiratory arrest	167.16	14.91	10	152374	108500	79483504
Sepsis	167.11	14.91	161	152223	269267	79322737
Hyperkalaemia	166.27	14.91	14	152370	114384	79477620
Inflammatory bowel disease	165.51	14.91	114	152270	5537	79586467
Depressed level of consciousness	165.47	14.91	4	152380	96648	79495356
Macule	164.80	14.91	90	152294	2867	79589137
Osteoarthritis	164.60	14.91	451	151933	86858	79505146
Helicobacter infection	163.47	14.91	391	151993	69313	79522691
Gastrointestinal haemorrhage	162.37	14.91	41	152343	147678	79444326
Cardiac failure	158.98	14.91	49	152335	154793	79437211
Neck pain	158.85	14.91	406	151978	75011	79516993
Seizure	157.60	14.91	82	152302	188752	79403252
Dyspnoea	154.87	14.91	982	151402	856043	78735961
Blister	154.36	14.91	541	151843	118935	79473069
Therapy cessation	151.73	14.91	264	152120	37298	79554706
Ankylosing spondylitis	150.70	14.91	149	152235	12056	79579948
C-reactive protein abnormal	150.52	14.91	304	152080	48063	79543941
Neutrophil count decreased	149.93	14.91	7	152377	93952	79498052
Multiple organ dysfunction syndrome	149.46	14.91	25	152359	120221	79471783
Overdose	149.32	14.91	83	152301	184123	79407881
Peripheral swelling	147.74	14.91	951	151433	268666	79323338
Sinusitis	147.45	14.91	751	151633	194750	79397254
Oxygen saturation decreased	147.38	14.91	33	152351	129014	79462990
Electrocardiogram QT prolonged	146.65	14.91	6	152378	90380	79501624
Blood cholesterol increased	146.56	14.91	421	151963	83299	79508705
Decreased immune responsiveness	145.34	14.91	104	152280	5371	79586633
Therapeutic response shortened	144.95	14.91	165	152219	15698	79576306
Uveitis	143.62	14.91	169	152215	16661	79575343
Syncope	142.39	14.91	83	152301	179366	79412638
Hypoxia	141.20	14.91	16	152368	103227	79488777
Pulmonary embolism	141.09	14.91	76	152308	171578	79420426
Intentional overdose	141.03	14.91	18	152366	105942	79486062
Pleural effusion	140.34	14.91	51	152333	145211	79446793
International normalised ratio increased	139.59	14.91	5	152379	84716	79507288
Cardiac failure congestive	137.57	14.91	50	152334	142352	79449652
Atrial fibrillation	136.30	14.91	107	152277	197779	79394225
Alopecia	134.77	14.91	829	151555	230526	79361478
Hip arthroplasty	133.74	14.91	243	152141	35513	79556491
Rhinorrhoea	133.59	14.91	383	152001	75691	79516313
Lip dry	133.53	14.91	156	152228	15262	79576742
Intentional product misuse	132.05	14.91	14	152370	95151	79496853
Coma	131.79	14.91	18	152366	100631	79491373
Facet joint syndrome	130.40	14.91	133	152251	11169	79580835
Tachycardia	129.04	14.91	91	152293	177677	79414327
Injection site haemorrhage	128.72	14.91	208	152176	27662	79564342
Gait inability	128.05	14.91	321	152063	58596	79533408
Knee arthroplasty	127.70	14.91	266	152118	42982	79549022
Hypersensitivity	127.47	14.91	898	151486	261341	79330663
Adjustment disorder with depressed mood	127.45	14.91	119	152265	8967	79583037
Product use issue	127.38	14.91	760	151624	209062	79382942
Metabolic acidosis	125.93	14.91	8	152376	82521	79509483
Joint stiffness	122.75	14.91	253	152131	40577	79551427
Swelling	122.12	14.91	770	151614	215941	79376063
Lower respiratory tract infection	122.00	14.91	530	151854	128690	79463314
Drug tolerance decreased	121.99	14.91	137	152247	12841	79579163
Bursitis	119.62	14.91	232	152152	35612	79556392
Contraindicated product administered	119.33	14.91	606	151778	156932	79435072
Dactylitis	118.95	14.91	71	152313	2686	79589318
Product prescribing error	117.84	14.91	263	152121	44550	79547454
Renal impairment	116.86	14.91	79	152305	157704	79434300
Hyperglycaemia	116.40	14.91	4	152380	70331	79521673
Retinitis	116.03	14.91	92	152292	5551	79586453
Agitation	114.86	14.91	25	152359	99690	79492314
Tremor	114.57	14.91	94	152290	169989	79422015
Loss of consciousness	114.15	14.91	92	152292	167851	79424153
Deep vein thrombosis postoperative	114.13	14.91	121	152263	10631	79581373
Off label use	113.97	14.91	1147	151237	906068	78685936
Red blood cell sedimentation rate increased	113.45	14.91	263	152121	45679	79546325
Epistaxis	113.18	14.91	36	152348	111479	79480525
Hallucination	113.06	14.91	15	152369	85730	79506274
Incorrect route of product administration	112.83	14.91	223	152161	34706	79557298
Hypoglycaemia	108.20	14.91	30	152354	101564	79490440
Product storage error	108.18	14.91	144	152240	16082	79575922
Tonsillitis	108.05	14.91	95	152289	6619	79585385
Wound infection	106.66	14.91	176	152208	23815	79568189
Red blood cell sedimentation rate	106.51	14.91	87	152297	5478	79586526
Bone erosion	104.85	14.91	149	152235	17698	79574306
Spinal pain	101.70	14.91	136	152248	15256	79576748
Fall	101.60	14.91	533	151851	487096	79104908
Injection site bruising	101.55	14.91	235	152149	40767	79551237
Lactic acidosis	101.17	14.91	9	152375	70350	79521654
Pharyngitis streptococcal	100.54	14.91	113	152271	10601	79581403
Folliculitis	100.32	14.91	282	152102	55098	79536906
Fear of injection	99.32	14.91	95	152289	7379	79584625
Blood creatine phosphokinase increased	99.09	14.91	7	152377	66083	79525921
Encephalopathy	98.61	14.91	8	152376	67389	79524615
Septic shock	98.53	14.91	56	152328	122745	79469259
Skin fissures	98.08	14.91	123	152261	12950	79579054
Peripheral venous disease	96.70	14.91	135	152249	15774	79576230
Concomitant disease aggravated	95.80	14.91	122	152262	13045	79578959
Drug reaction with eosinophilia and systemic symptoms	95.76	14.91	7	152377	64237	79527767
Maternal exposure during pregnancy	95.64	14.91	514	151870	136024	79455980
Neuropathy peripheral	95.28	14.91	78	152306	141227	79450777
Pain of skin	94.84	14.91	128	152256	14485	79577519
Tenosynovitis	94.56	14.91	132	152252	15422	79576582
Tendonitis	94.30	14.91	166	152218	23664	79568340
Injury	94.15	14.91	344	152040	77152	79514852
Movement disorder	94.10	14.91	179	152205	27080	79564924
Pulmonary oedema	94.10	14.91	26	152358	88228	79503776
Mental status changes	92.51	14.91	10	152374	66949	79525055
Joint range of motion decreased	91.66	14.91	199	152185	33083	79558921
Joint dislocation	91.63	14.91	136	152248	16803	79575201
Sacroiliitis	89.88	14.91	67	152317	3687	79588317
Autoimmune disorder	89.32	14.91	133	152251	16479	79575525
Night sweats	89.24	14.91	260	152124	51835	79540169
Hepatic function abnormal	89.08	14.91	16	152368	73091	79518913
Wrong technique in device usage process	87.86	14.91	68	152316	3960	79588044
Respiratory arrest	86.56	14.91	6	152378	57544	79534460
Laryngitis	85.65	14.91	128	152256	15911	79576093
Interstitial lung disease	85.23	14.91	55	152329	112545	79479459
Incorrect dose administered by device	85.15	14.91	73	152311	4916	79587088
Cholestasis	82.75	14.91	4	152380	52105	79539899
Product distribution issue	82.48	14.91	44	152340	1336	79590668
Exostosis	82.22	14.91	129	152255	16729	79575275
Therapy non-responder	82.11	14.91	372	152012	91933	79500071
Suicide attempt	82.00	14.91	28	152356	82904	79509100
Anti-cyclic citrullinated peptide antibody	80.84	14.91	76	152308	5776	79586228
Unresponsive to stimuli	80.58	14.91	7	152377	55781	79536223
Alanine aminotransferase abnormal	78.93	14.91	91	152293	8776	79583228
Lupus-like syndrome	78.93	14.91	114	152270	13743	79578261
Plasma cell myeloma	78.82	14.91	6	152378	53253	79538751
Mycotic allergy	78.53	14.91	44	152340	1475	79590529
Bone marrow failure	77.83	14.91	5	152379	51102	79540902
Leukopenia	77.70	14.91	65	152319	116448	79475556
Aggression	77.56	14.91	5	152379	50953	79541051
Scab	76.98	14.91	98	152286	10474	79581530
Skin disorder	76.98	14.91	188	152196	33755	79558249
Oral candidiasis	76.90	14.91	173	152211	29455	79562549
Irritable bowel syndrome	76.20	14.91	277	152107	61964	79530040
Orthostatic hypotension	76.05	14.91	9	152375	56155	79535849
Balance disorder	75.21	14.91	48	152336	98809	79493195
Hepatic cirrhosis	74.60	14.91	189	152195	34717	79557287
Blood bilirubin increased	73.50	14.91	18	152366	66214	79525790
Hypocalcaemia	72.83	14.91	6	152378	49918	79542086
Melaena	72.74	14.91	14	152370	60876	79531128
Mucosal inflammation	72.19	14.91	27	152357	75553	79516451
Toxic epidermal necrolysis	72.17	14.91	3	152381	44578	79547426
Secretion discharge	71.95	14.91	114	152270	14908	79577096
Limb discomfort	71.38	14.91	179	152205	32671	79559333
Vomiting	70.65	14.91	874	151510	664954	78927050
Hypomagnesaemia	70.23	14.91	5	152379	46906	79545098
Nail psoriasis	70.21	14.91	31	152353	614	79591390
Adverse drug reaction	70.20	14.91	282	152102	66110	79525894
Product dispensing error	69.61	14.91	105	152279	13158	79578846
Sinus congestion	69.11	14.91	131	152253	19765	79572239
Hypervolaemia	68.69	14.91	3	152381	42687	79549317
Acute respiratory failure	68.42	14.91	15	152369	59526	79532478
Neurologic neglect syndrome	67.64	14.91	51	152333	2856	79589148
Carotid artery thrombosis	67.59	14.91	52	152332	3001	79589003
Blood pressure fluctuation	67.55	14.91	22	152362	67123	79524881
Erysipelas	67.33	14.91	93	152291	10757	79581247
Cardiogenic shock	67.26	14.91	3	152381	41911	79550093
Vein rupture	66.62	14.91	44	152340	1992	79590012
Hepatic enzyme increased	66.39	14.91	585	151799	182025	79409979
Hepatocellular injury	66.02	14.91	7	152377	47586	79544418
Cognitive disorder	65.10	14.91	26	152358	69900	79522104
Accidental exposure to product	64.25	14.91	167	152217	31155	79560849
Sciatica	63.96	14.91	173	152211	33049	79558955
Urinary retention	63.60	14.91	15	152369	56615	79535389
Gait disturbance	63.59	14.91	641	151743	206865	79385139
Rebound psoriasis	63.21	14.91	21	152363	182	79591822
Upper gastrointestinal haemorrhage	63.16	14.91	4	152380	41376	79550628
Ascites	62.72	14.91	33	152351	75529	79516475
Deep vein thrombosis	62.14	14.91	84	152300	120835	79471169
Generalised tonic-clonic seizure	62.10	14.91	6	152378	43904	79548100
Altered state of consciousness	61.94	14.91	6	152378	43816	79548188
Dyspnoea exertional	60.02	14.91	47	152337	87026	79504978
Joint ankylosis	59.22	14.91	42	152342	2138	79589866
Respiratory tract congestion	59.21	14.91	123	152261	19831	79572173
Breast cancer stage III	59.15	14.91	83	152301	9743	79582261
Disorientation	59.00	14.91	23	152361	62753	79529251
Shock	58.91	14.91	7	152377	43541	79548463
Rash maculo-papular	58.89	14.91	17	152367	56061	79535943
Scratch	58.50	14.91	76	152308	8287	79583717
Dry skin	58.21	14.91	271	152113	67724	79524280
Localised infection	58.19	14.91	181	152203	37394	79554610
Pustular psoriasis	58.09	14.91	58	152326	4748	79587256
Chronic kidney disease	57.77	14.91	27	152357	66127	79525877
Pneumonitis	57.69	14.91	22	152362	60838	79531166
Pneumonia aspiration	57.45	14.91	28	152356	66939	79525065
Cytomegalovirus infection	57.33	14.91	7	152377	42637	79549367
C-reactive protein	56.37	14.91	58	152326	4921	79587083
Lower limb fracture	56.32	14.91	132	152252	23083	79568921
Ventricular tachycardia	56.09	14.91	7	152377	41928	79550076
Liver function test abnormal	55.25	14.91	27	152357	64448	79527556
Spondylitis	55.17	14.91	56	152328	4675	79587329
Heart rate decreased	55.07	14.91	33	152351	70283	79521721
Tubulointerstitial nephritis	54.67	14.91	5	152379	38230	79553774
Jaundice	54.52	14.91	17	152367	53332	79538672
Cerebral haemorrhage	54.42	14.91	21	152363	57652	79534352
Urticaria	53.83	14.91	566	151818	184635	79407369
Pulmonary hypertension	53.48	14.91	13	152371	48067	79543937
Hypoaesthesia	53.01	14.91	550	151834	178802	79413202
Blood potassium decreased	52.87	14.91	12	152372	46500	79545504
Disability	52.53	14.91	107	152277	17013	79574991
Pericardial effusion	52.42	14.91	12	152372	46225	79545779
Foot deformity	52.12	14.91	131	152253	23943	79568061
Haematocrit decreased	52.05	14.91	26	152358	61286	79530718
Dyskinesia	52.01	14.91	11	152373	44762	79547242
Psoriasis area severity index increased	51.51	14.91	16	152368	109	79591895
Nail disorder	51.41	14.91	86	152298	11766	79580238
Stevens-Johnson syndrome	51.27	14.91	7	152377	39159	79552845
Cutaneous T-cell lymphoma	51.19	14.91	42	152342	2661	79589343
Tonsillar ulcer	51.10	14.91	22	152362	409	79591595
Hypophagia	50.98	14.91	12	152372	45355	79546649
Red blood cell count decreased	50.95	14.91	23	152361	57490	79534514
Multiple sclerosis relapse	50.94	14.91	13	152371	46520	79545484
Erythema	50.87	14.91	651	151733	222639	79369365
Back pain	50.77	14.91	840	151544	303340	79288664
Coagulopathy	50.71	14.91	5	152379	36001	79556003
Psychotic disorder	50.57	14.91	9	152375	41393	79550611
Device defective	49.88	14.91	36	152348	1884	79590120
Sinus tachycardia	49.76	14.91	6	152378	36902	79555102
Insurance issue	49.63	14.91	58	152326	5675	79586329
Coronary artery disease	49.51	14.91	32	152352	65442	79526562
Haematemesis	49.36	14.91	19	152365	52245	79539759
Respiratory distress	49.13	14.91	25	152359	58314	79533690
Colitis ulcerative	48.93	14.91	162	152222	34580	79557424
Abnormal behaviour	48.91	14.91	6	152378	36415	79555589
Obesity	48.77	14.91	163	152221	34962	79557042
Fungal infection	48.75	14.91	183	152201	41565	79550439
Muscle injury	48.75	14.91	203	152181	48358	79543646
Cystitis	48.74	14.91	215	152169	52517	79539487
Spinal fusion surgery	48.73	14.91	55	152329	5183	79586821
Onychomadesis	48.69	14.91	55	152329	5187	79586817
Confusional state	48.51	14.91	382	152002	317615	79274389
SARS-CoV-2 test positive	48.16	14.91	83	152301	11633	79580371
Spondyloarthropathy	47.94	14.91	28	152356	1017	79590987
Thrombosis	47.85	14.91	54	152330	84046	79507958
Sneezing	47.84	14.91	112	152272	19571	79572433
Acne	47.81	14.91	137	152247	27053	79564951
Palmoplantar pustulosis	47.75	14.91	23	152361	560	79591444
Haematoma	47.62	14.91	20	152364	52175	79539829
Tenderness	47.41	14.91	125	152259	23517	79568487
Eosinophilia	47.15	14.91	14	152370	45331	79546673
Pancreatitis acute	46.91	14.91	18	152366	49586	79542418
Influenza like illness	46.86	14.91	265	152119	71442	79520562
Lymphocyte count decreased	46.68	14.91	16	152368	47273	79544731
Symptom recurrence	46.03	14.91	37	152347	2277	79589727
Pallor	45.97	14.91	19	152365	50043	79541961
Self-consciousness	45.90	14.91	14	152370	89	79591915
Blood alkaline phosphatase increased	45.63	14.91	33	152351	63631	79528373
Skin burning sensation	45.62	14.91	87	152297	13185	79578819
Subdural haematoma	45.24	14.91	4	152380	31430	79560574
Musculoskeletal discomfort	45.12	14.91	110	152274	19725	79572279
Blood creatinine increased	44.94	14.91	149	152235	154908	79437096
Skin injury	44.70	14.91	43	152341	3363	79588641
Acute myeloid leukaemia	44.26	14.91	4	152380	30881	79561123
Road traffic accident	44.20	14.91	183	152201	43481	79548523
Hypercholesterolaemia	44.19	14.91	120	152264	22975	79569029
X-ray abnormal	44.10	14.91	55	152329	5758	79586246
Atelectasis	44.09	14.91	5	152379	32252	79559752
Blood urea increased	44.03	14.91	19	152365	48771	79543233
Drug resistance	43.95	14.91	13	152371	42200	79549804
Disturbance in attention	43.95	14.91	21	152363	50780	79541224
Tachypnoea	43.75	14.91	5	152379	32058	79559946
Venous injury	43.56	14.91	24	152360	778	79591226
Lupus vulgaris	43.46	14.91	42	152342	3304	79588700
Myocardial infarction	43.04	14.91	193	152191	183936	79408068
Stress	43.00	14.91	280	152104	79332	79512672
Full blood count abnormal	43.00	14.91	12	152372	40462	79551542
Ligament calcification	42.58	14.91	16	152368	205	79591799
Cerebral infarction	42.49	14.91	17	152367	45659	79546345
Adjustment disorder	42.42	14.91	45	152339	3955	79588049
Haemorrhage	42.22	14.91	68	152316	91050	79500954
Acute myocardial infarction	42.18	14.91	51	152333	76985	79515019
Presyncope	42.10	14.91	13	152371	41041	79550963
Blood glucose increased	41.83	14.91	99	152285	114876	79477128
Oedema peripheral	41.83	14.91	296	152088	251992	79340012
Aspartate aminotransferase increased	41.73	14.91	131	152253	138510	79453494
Therapeutic response decreased	41.69	14.91	244	152140	66609	79525395
Acute respiratory distress syndrome	41.65	14.91	16	152368	44051	79547953
Live birth	41.63	14.91	103	152281	18641	79573363
Myoclonus	41.26	14.91	3	152381	27657	79564347
Panniculitis	41.18	14.91	80	152304	12291	79579713
Granuloma	41.17	14.91	64	152320	8233	79583771
Rash	40.92	14.91	1418	150966	576940	79015064
Blood calcium decreased	40.92	14.91	6	152378	31813	79560191
Dysgeusia	40.51	14.91	30	152354	57147	79534857
Haematuria	40.49	14.91	43	152341	68793	79523211
Diabetic ketoacidosis	40.43	14.91	8	152376	34114	79557890
Hypermobility syndrome	40.25	14.91	20	152364	522	79591482
Guttate psoriasis	40.00	14.91	19	152365	448	79591556
Arrhythmia	39.84	14.91	35	152349	61237	79530767
Pustule	39.48	14.91	32	152352	1993	79590011
Gastrointestinal pain	39.44	14.91	69	152315	9786	79582218
Blood lactate dehydrogenase increased	39.11	14.91	13	152371	39157	79552847
Leukocytosis	39.09	14.91	17	152367	43438	79548566
Hypothyroidism	39.08	14.91	26	152358	52366	79539638
Musculoskeletal pain	38.79	14.91	331	152053	102023	79489981
Blood parathyroid hormone decreased	38.62	14.91	71	152313	10465	79581539
Personality disorder	38.62	14.91	53	152331	6093	79585911
Blood pressure decreased	38.34	14.91	83	152301	99383	79492621
Obstructive airways disorder	38.07	14.91	7	152377	31452	79560552
Papule	37.97	14.91	58	152326	7349	79584655
Tongue disorder	37.84	14.91	83	152301	13892	79578112
Intentional self-injury	37.58	14.91	8	152376	32411	79559593
Hepatic failure	37.40	14.91	37	152347	61175	79530829
Hidradenitis	37.28	14.91	37	152347	3007	79588997
Gastric disorder	37.19	14.91	156	152228	37277	79554727
Flushing	37.14	14.91	70	152314	88198	79503806
Electrolyte imbalance	37.10	14.91	7	152377	30874	79561130
Tooth abscess	36.98	14.91	90	152294	16120	79575884
Dysstasia	36.98	14.91	127	152257	27619	79564385
Brain oedema	36.95	14.91	3	152381	25260	79566744
Intestinal obstruction	36.88	14.91	18	152366	43002	79549002
Lymphopenia	36.55	14.91	7	152377	30550	79561454
Axial spondyloarthritis	35.92	14.91	19	152365	567	79591437
Bone lesion	35.63	14.91	50	152334	5869	79586135
Walking aid user	35.47	14.91	67	152317	10081	79581923
Mitral valve incompetence	35.35	14.91	6	152378	28559	79563445
Drug dependence	35.04	14.91	17	152367	40752	79551252
Oral lichen planus	34.93	14.91	21	152363	805	79591199
Chronic obstructive pulmonary disease	34.85	14.91	69	152315	85350	79506654
Burning sensation	34.64	14.91	211	152173	58421	79533583
Adverse event	34.51	14.91	215	152169	59999	79532005
Cellulitis	34.39	14.91	339	152045	108721	79483283
Ataxia	33.93	14.91	4	152380	25035	79566969
Renal tubular necrosis	33.93	14.91	4	152380	25035	79566969
Pancreatitis	33.86	14.91	49	152335	68526	79523478
Acute hepatic failure	33.77	14.91	8	152376	30105	79561899
Ejection fraction decreased	33.61	14.91	12	152372	34565	79557439
Nasal congestion	33.59	14.91	256	152128	76296	79515708
Ileus	33.57	14.91	5	152379	26206	79565798
Accident	32.99	14.91	60	152324	8771	79583233
Eczema	32.98	14.91	160	152224	40658	79551346
Subarachnoid haemorrhage	32.92	14.91	4	152380	24461	79567543
Hepatotoxicity	32.59	14.91	30	152354	51322	79540682
Hypothermia	32.45	14.91	3	152381	22743	79569261
Hepatic encephalopathy	32.40	14.91	4	152380	24162	79567842
Asthenia	32.34	14.91	738	151646	510951	79081053
Product label confusion	32.34	14.91	26	152358	1600	79590404
Myelodysplastic syndrome	32.16	14.91	9	152375	30292	79561712
Lower respiratory tract infection viral	31.98	14.91	23	152361	1197	79590807
Impaired healing	31.92	14.91	281	152103	87374	79504630
Cough	31.86	14.91	922	151462	365867	79226137
Cardiomyopathy	31.57	14.91	8	152376	28766	79563238
Sleep disorder	31.38	14.91	275	152109	85402	79506602
Drug ineffective for unapproved indication	31.27	14.91	31	152353	51207	79540797
Tuberculosis	31.13	14.91	81	152303	15117	79576887
Dermatitis psoriasiform	30.64	14.91	32	152352	2762	79589242
Injection site pain	30.59	14.91	381	152003	129457	79462547
Full blood count decreased	30.32	14.91	7	152377	26812	79565192
Kidney infection	29.98	14.91	101	152283	21750	79570254
Rectal haemorrhage	29.96	14.91	63	152321	76237	79515767
Headache	29.87	14.91	1531	150853	652241	78939763
Transient ischaemic attack	29.80	14.91	34	152350	52661	79539343
Fatigue	29.68	14.91	2109	150275	927618	78664386
Cyanosis	29.64	14.91	6	152378	25176	79566828
Wheezing	29.51	14.91	347	152037	116317	79475687
Muscle swelling	29.46	14.91	19	152365	826	79591178
Pyoderma gangrenosum	29.42	14.91	38	152346	4120	79587884
Adrenal insufficiency	29.25	14.91	9	152375	28478	79563526
Pain in jaw	29.24	14.91	27	152357	46124	79545880
Anaphylactic reaction	28.98	14.91	74	152310	83669	79508335
Rheumatoid nodule	28.87	14.91	86	152298	17352	79574652
Rheumatoid lung	28.80	14.91	38	152346	4207	79587797
Pneumocystis jirovecii pneumonia	28.79	14.91	13	152371	32495	79559509
Onycholysis	28.67	14.91	27	152357	2056	79589948
Motor dysfunction	28.63	14.91	77	152307	14656	79577348
Myopathy	28.58	14.91	3	152381	20560	79571444
Device related infection	28.42	14.91	15	152369	34279	79557725
Joint injury	28.38	14.91	127	152257	31208	79560796
Blood sodium decreased	28.38	14.91	14	152370	33241	79558763
Therapeutic product effect delayed	28.36	14.91	32	152352	3014	79588990
Sinus disorder	28.36	14.91	101	152283	22363	79569641
Haemophagocytic lymphohistiocytosis	28.35	14.91	4	152380	21833	79570171
Myocarditis	28.17	14.91	4	152380	21729	79570275
Tinnitus	28.02	14.91	26	152358	44307	79547697
Lung infiltration	27.94	14.91	5	152379	22907	79569097
Polyneuropathy	27.92	14.91	6	152378	24145	79567859
Abscess limb	27.86	14.91	49	152335	6978	79585026
Bacteraemia	27.74	14.91	14	152370	32810	79559194
Injection site papule	27.65	14.91	19	152365	919	79591085
Gastrooesophageal reflux disease	27.64	14.91	104	152280	104142	79487862
Ear infection fungal	27.58	14.91	12	152372	229	79591775
Skin infection	27.43	14.91	87	152297	18158	79573846
Feeling abnormal	27.40	14.91	442	151942	158757	79433247
Supraventricular tachycardia	27.38	14.91	4	152380	21266	79570738
Proteinuria	27.26	14.91	14	152370	32488	79559516
Metastases to liver	27.23	14.91	10	152374	28304	79563700
Bronchiectasis	27.05	14.91	5	152379	22381	79569623
Musculoskeletal deformity	27.03	14.91	23	152361	1533	79590471
Rhesus antigen positive	26.91	14.91	10	152374	124	79591880
Tinea pedis	26.86	14.91	28	152356	2412	79589592
Premature delivery	26.78	14.91	6	152378	23461	79568543
Body temperature decreased	26.69	14.91	127	152257	32018	79559986
Loose body in joint	26.38	14.91	21	152363	1274	79590730
Hallucination, auditory	26.38	14.91	4	152380	20689	79571315
Skin discomfort	26.34	14.91	17	152367	740	79591264
Induration	26.29	14.91	25	152359	1927	79590077
Skin irritation	26.28	14.91	63	152321	11177	79580827
Genital candidiasis	26.01	14.91	10	152374	137	79591867
Inflammatory pain	25.87	14.91	19	152365	1022	79590982
Cytopenia	25.85	14.91	4	152380	20379	79571625
Cardiac failure acute	25.71	14.91	3	152381	18926	79573078
Anosmia	25.64	14.91	54	152330	8790	79583214
Clostridium difficile colitis	25.49	14.91	15	152369	32268	79559736
General physical health deterioration	25.31	14.91	697	151687	274541	79317463
Hypoalbuminaemia	25.22	14.91	5	152379	21292	79570712
Chronic disease	25.12	14.91	10	152374	151	79591853
Urinary incontinence	24.68	14.91	25	152359	40884	79551120
Dyshidrotic eczema	24.65	14.91	15	152369	588	79591416
Nausea	24.61	14.91	1539	150845	955657	78636347
Xyphoid retraction	24.43	14.91	10	152374	163	79591841
Abscess sweat gland	24.38	14.91	6	152378	14	79591990
Sensory loss	24.35	14.91	67	152317	12924	79579080
Granuloma skin	24.29	14.91	54	152330	9120	79582884
Angiocardiogram	24.19	14.91	11	152373	234	79591770
Poisoning	24.18	14.91	9	152375	25263	79566741
Hyperthermia	24.15	14.91	3	152381	18034	79573970
Petechiae	23.99	14.91	5	152379	20560	79571444
Aplastic anaemia	23.92	14.91	3	152381	17902	79574102
Hepatic cytolysis	23.83	14.91	11	152373	27140	79564864
Peritonitis	23.63	14.91	12	152372	28024	79563980
Pharyngitis	23.61	14.91	95	152289	22280	79569724
Product substitution issue	23.48	14.91	5	152379	20251	79571753
Muscle twitching	23.39	14.91	9	152375	24755	79567249
No adverse event	23.28	14.91	22	152362	37170	79554834
Tooth infection	23.20	14.91	84	152300	18748	79573256
Iron deficiency anaemia	23.16	14.91	10	152374	25662	79566342
Fluid retention	23.15	14.91	63	152321	69746	79522258
Skin swelling	22.82	14.91	33	152351	3981	79588023
Anuria	22.67	14.91	6	152378	20957	79571047
Collagen-vascular disease	22.63	14.91	8	152376	85	79591919
Alanine aminotransferase increased	22.62	14.91	200	152184	162370	79429634
Tricuspid valve incompetence	22.57	14.91	5	152379	19707	79572297
Pseudomonas infection	22.57	14.91	6	152378	20897	79571107
Gastrointestinal disorder	22.43	14.91	343	152041	121862	79470142
Body surface area increased	22.25	14.91	9	152375	142	79591862
Mania	22.23	14.91	4	152380	18256	79573748
Renal injury	22.22	14.91	3	152381	16924	79575080
Lichen planus	22.13	14.91	27	152357	2764	79589240
Atrial flutter	21.90	14.91	7	152377	21618	79570386
Eye infection	21.87	14.91	61	152323	11859	79580145
Manufacturing product shipping issue	21.84	14.91	8	152376	95	79591909
Ear pain	21.82	14.91	122	152262	32747	79559257
Troponin increased	21.82	14.91	5	152379	19250	79572754
Basal cell carcinoma	21.75	14.91	134	152250	37241	79554763
Irritability	21.72	14.91	28	152356	41116	79550888
Gamma-glutamyltransferase increased	21.59	14.91	45	152339	54635	79537369
Sudden death	21.56	14.91	8	152376	22503	79569501
Genital cyst	21.56	14.91	7	152377	56	79591948
Malnutrition	21.55	14.91	8	152376	22494	79569510
Nasal discomfort	21.44	14.91	38	152346	5445	79586559
Aspiration	21.37	14.91	6	152378	20152	79571852
Restlessness	21.25	14.91	35	152349	46457	79545547
Vulval cancer stage III	21.18	14.91	5	152379	9	79591995
Cardiomegaly	21.15	14.91	12	152372	26340	79565664
Rales	21.11	14.91	6	152378	19995	79572009
Ulcer	21.07	14.91	113	152271	29859	79562145
HLA-B*27 positive	20.91	14.91	8	152376	108	79591896
Body mass index abnormal	20.89	14.91	10	152374	240	79591764
Breast cancer	20.86	14.91	123	152261	33658	79558346
Heart rate irregular	20.85	14.91	19	152365	32660	79559344
Coronavirus infection	20.84	14.91	45	152339	7452	79584552
Meningitis streptococcal	20.82	14.91	9	152375	169	79591835
Laboratory test abnormal	20.81	14.91	14	152370	28034	79563970
Diplopia	20.71	14.91	20	152364	33446	79558558
Anaphylactic shock	20.60	14.91	23	152361	35973	79556031
Contusion	20.58	14.91	399	151985	148377	79443627
Tendon pain	20.58	14.91	38	152346	5620	79586384
Dialysis	20.51	14.91	5	152379	18457	79573547
Gastrointestinal infection	20.39	14.91	58	152326	11403	79580601
Eating disorder	20.36	14.91	86	152298	20611	79571393
Tinea versicolour	20.32	14.91	11	152373	344	79591660
Actinic keratosis	20.02	14.91	39	152345	6003	79586001
Red cell distribution width decreased	19.99	14.91	22	152362	2016	79589988
Prothrombin time prolonged	19.94	14.91	4	152380	16895	79575109
Hyperhidrosis	19.94	14.91	189	152195	151303	79440701
Wrong schedule	19.93	14.91	11	152373	358	79591646
Palate injury	19.92	14.91	7	152377	73	79591931
Ill-defined disorder	19.91	14.91	203	152181	65672	79526332
Medication error	19.85	14.91	66	152318	68576	79523428
Respiratory tract infection	19.80	14.91	160	152224	48529	79543475
Metastases to bone	19.78	14.91	11	152373	24416	79567588
Liver function test increased	19.74	14.91	137	152247	39636	79552368
Small intestinal obstruction	19.72	14.91	14	152370	27258	79564746
Device issue	19.60	14.91	103	152281	27005	79564999
Hepatic enzyme abnormal	19.59	14.91	45	152339	7765	79584239
Hepatitis	19.47	14.91	49	152335	55678	79536326
Oedema	19.46	14.91	329	152055	119251	79472753
Erythematotelangiectatic rosacea	19.41	14.91	5	152379	15	79591989
Epilepsy	19.39	14.91	30	152354	40830	79551174
Bronchitis	19.32	14.91	354	152030	130290	79461714
Lip ulceration	19.26	14.91	23	152361	2302	79589702
Groin infection	19.25	14.91	13	152371	611	79591393
Scarlet fever	19.23	14.91	8	152376	136	79591868
Bronchospasm	19.00	14.91	12	152372	24847	79567157
Drug-device interaction	18.97	14.91	7	152377	85	79591919
Retching	18.89	14.91	5	152379	17462	79574542
Hypertensive crisis	18.88	14.91	8	152376	20762	79571242
Vascular access complication	18.76	14.91	22	152362	2160	79589844
Vision blurred	18.65	14.91	122	152262	105776	79486228
Dermatitis exfoliative generalised	18.47	14.91	42	152342	7199	79584805
Skin necrosis	18.45	14.91	76	152308	18011	79573993
Latent tuberculosis	18.25	14.91	27	152357	3326	79588678
Product supply issue	18.20	14.91	21	152363	2027	79589977
Affect lability	18.14	14.91	55	152329	11204	79580800
Toxic skin eruption	18.11	14.91	10	152374	22283	79569721
Aspergillus infection	18.04	14.91	7	152377	19154	79572850
Rash pustular	17.99	14.91	55	152329	11256	79580748
Prescribed underdose	17.93	14.91	107	152277	29407	79562597
Decubitus ulcer	17.92	14.91	4	152380	15683	79576321
Papulopustular rosacea	17.92	14.91	5	152379	22	79591982
Unevaluable event	17.81	14.91	51	152333	55534	79536470
Visual acuity reduced	17.79	14.91	18	152366	29451	79562553
Neutrophil count increased	17.69	14.91	18	152366	29378	79562626
Diverticulitis	17.63	14.91	149	152235	45787	79546217
Product availability issue	17.60	14.91	29	152355	3918	79588086
Finger deformity	17.59	14.91	42	152342	7432	79584572
Angioimmunoblastic T-cell lymphoma	17.59	14.91	11	152373	453	79591551
Circulatory collapse	17.55	14.91	28	152356	37640	79554364
Drug tolerance	17.53	14.91	46	152338	8629	79583375
Oligoarthritis	17.51	14.91	13	152371	711	79591293
Atrioventricular block complete	17.50	14.91	5	152379	16605	79575399
Skin oedema	17.43	14.91	19	152365	1722	79590282
Otorrhoea	17.40	14.91	19	152365	1726	79590278
Urosepsis	17.39	14.91	15	152369	26480	79565524
Blood magnesium decreased	17.34	14.91	5	152379	16507	79575497
Cutaneous lymphoma	17.31	14.91	9	152375	259	79591745
Myocardial ischaemia	17.30	14.91	14	152370	25505	79566499
Viral infection	17.30	14.91	141	152243	42875	79549129
Lipase increased	17.27	14.91	5	152379	16461	79575543
Aphthous ulcer	17.26	14.91	71	152313	16818	79575186
Terminal insomnia	17.18	14.91	16	152368	1201	79590803
Mouth ulceration	17.18	14.91	129	152255	38265	79553739
Complication associated with device	17.13	14.91	6	152378	17490	79574514
Metastases to central nervous system	17.12	14.91	5	152379	16370	79575634
Respiratory rate increased	17.10	14.91	10	152374	21590	79570414
Pigmentation disorder	17.10	14.91	35	152349	5583	79586421
Gastric ulcer	16.96	14.91	24	152360	33881	79558123
Oral pustule	16.91	14.91	9	152375	272	79591732
Paraesthesia oral	16.90	14.91	9	152375	20462	79571542
Pregnancy on contraceptive	16.87	14.91	14	152370	901	79591103
Dizziness	16.87	14.91	828	151556	525613	79066391
Polyuria	16.81	14.91	4	152380	15010	79576994
Oral lichenoid reaction	16.78	14.91	7	152377	120	79591884
Peritonsillar abscess	16.73	14.91	14	152370	912	79591092
Benign laryngeal neoplasm	16.64	14.91	5	152379	30	79591974
Nightmare	16.54	14.91	15	152369	25846	79566158
Muscle spasticity	16.51	14.91	83	152301	21392	79570612
Cell marker increased	16.44	14.91	12	152372	639	79591365
Onychalgia	16.39	14.91	14	152370	938	79591066
Blindness	16.39	14.91	18	152366	28365	79563639
Renal disorder	16.33	14.91	35	152349	42070	79549934
Tongue ulceration	16.32	14.91	29	152355	4164	79587840
Clostridium difficile infection	16.13	14.91	36	152348	42649	79549355
Abdominal pain upper	16.07	14.91	550	151834	223269	79368735
Oesophageal infection	16.07	14.91	12	152372	662	79591342
Immune thrombocytopenia	15.96	14.91	7	152377	17798	79574206
Femur fracture	15.95	14.91	31	152353	38621	79553383
Energy increased	15.84	14.91	25	152359	3257	79588747
Epstein-Barr virus infection	15.83	14.91	4	152380	14412	79577592
White blood cell count increased	15.81	14.91	81	152303	74552	79517452
Otitis externa	15.61	14.91	21	152363	2369	79589635
Osteoporosis	15.52	14.91	165	152219	53947	79538057
Iritis	15.44	14.91	27	152357	3828	79588176
Hemiplegia	15.42	14.91	63	152321	14876	79577128
Haemoptysis	15.41	14.91	55	152329	55944	79536060
Stomatitis	15.32	14.91	378	152006	146379	79445625
Ecchymosis	15.26	14.91	5	152379	15201	79576803
Oral discomfort	15.09	14.91	47	152337	9713	79582291
Ischaemic stroke	15.09	14.91	25	152359	33106	79558898
Skin ulcer	15.02	14.91	164	152220	53986	79538018
Bone cyst	15.01	14.91	25	152359	3408	79588596

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L04AC10	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Interleukin inhibitors
FDA MoA	N0000191494	Interleukin-17A Antagonists
FDA EPC	N0000191495	Interleukin-17A Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ankylosing spondylitis	indication	9631008	DOID:7147
Psoriatic arthritis	indication	156370009	DOID:9008
Plaque psoriasis	indication	200965009
Pustular psoriasis	indication	200973000
Non-radiographic axial spondyloarthritis	indication	713777005

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Interleukin-17A	Cytokine	Q16552	IL17_HUMAN	ANTIBODY BINDING				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
D09967	KEGG_DRUG
4034154	VUID
N0000191427	NUI
4034154	VANDF
CHEMBL1743068	ChEMBL_ID
C555450	MESH_SUPPLEMENTAL_RECORD_UI
8078	IUPHAR_LIGAND_ID
DB09029	DRUGBANK_ID
1599788	RXNORM
232493	MMSL
30871	MMSL
d08341	MMSL
015879	NDDF
708822004	SNOMEDCT_US
714689007	SNOMEDCT_US
C3179547	UMLSCUI
9182	INN_ID
DLG4EML025	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
COSENTYX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0639	INJECTION	150 mg	SUBCUTANEOUS	BLA	32 sections
COSENTYX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0639	INJECTION	150 mg	SUBCUTANEOUS	BLA	32 sections
COSENTYX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0639	INJECTION	150 mg	SUBCUTANEOUS	BLA	32 sections
COSENTYX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-1056	INJECTION	75 mg	SUBCUTANEOUS	BLA	32 sections
COSENTYX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-1056	INJECTION	75 mg	SUBCUTANEOUS	BLA	32 sections
COSENTYX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-1056	INJECTION	75 mg	SUBCUTANEOUS	BLA	32 sections
COSENTYX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-1070	INJECTION	300 mg	SUBCUTANEOUS	BLA	32 sections