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| Stem definition | Drug id | CAS RN |
|---|---|---|
| interleukin receptor antagonists and interleukin antagonists | 5017 | 143090-92-0 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA. As IL-1 levels are elevated in patients with COVID-19, anakinra is currently being investigated for its potential to combat cytokine release syndrome (CRS) in patients with severely ill COVID-19.
|
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | P |
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 14, 2001 | FDA | BIOVITRUM AB | |
| March 8, 2002 | EMA |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug ineffective | 781.29 | 17.09 | 1868 | 40368 | 1382430 | 89203781 |
| Haemophagocytic lymphohistiocytosis | 727.34 | 17.09 | 273 | 41963 | 15186 | 90571025 |
| Red blood cell sedimentation rate abnormal | 706.38 | 17.09 | 303 | 41933 | 23901 | 90562310 |
| Polyarthritis | 592.95 | 17.09 | 247 | 41989 | 18103 | 90568108 |
| Adrenal insufficiency | 509.47 | 17.09 | 258 | 41978 | 29663 | 90556548 |
| Joint destruction | 501.64 | 17.09 | 200 | 42036 | 13087 | 90573124 |
| Off label use | 444.42 | 17.09 | 1317 | 40919 | 1100935 | 89485276 |
| Loss of consciousness | 420.77 | 17.09 | 416 | 41820 | 139822 | 90446389 |
| Body height below normal | 337.75 | 17.09 | 95 | 42141 | 2073 | 90584138 |
| Bone density decreased | 332.01 | 17.09 | 162 | 42074 | 17183 | 90569028 |
| Deformity | 317.96 | 17.09 | 141 | 42095 | 12029 | 90574182 |
| Human antichimeric antibody positive | 313.78 | 17.09 | 86 | 42150 | 1700 | 90584511 |
| Oral mucosal exfoliation | 295.58 | 17.09 | 82 | 42154 | 1698 | 90584513 |
| Mobility decreased | 287.23 | 17.09 | 459 | 41777 | 250275 | 90335936 |
| Wheelchair user | 275.90 | 17.09 | 112 | 42124 | 7673 | 90578538 |
| Immunodeficiency | 272.69 | 17.09 | 197 | 42039 | 43037 | 90543174 |
| Drug tolerance | 268.94 | 17.09 | 142 | 42094 | 17774 | 90568437 |
| Therapeutic product effect decreased | 267.11 | 17.09 | 470 | 41766 | 277101 | 90309110 |
| Musculoskeletal disorder | 259.04 | 17.09 | 148 | 42088 | 21621 | 90564590 |
| Nodule | 256.32 | 17.09 | 158 | 42078 | 26528 | 90559683 |
| Septic shock | 245.41 | 17.09 | 246 | 41990 | 83914 | 90502297 |
| Gastroenteritis viral | 235.25 | 17.09 | 157 | 42079 | 30198 | 90556013 |
| Herpes zoster | 233.56 | 17.09 | 253 | 41983 | 94391 | 90491820 |
| Synovitis | 230.88 | 17.09 | 488 | 41748 | 329264 | 90256947 |
| Drug intolerance | 228.55 | 17.09 | 585 | 41651 | 447006 | 90139205 |
| Ill-defined disorder | 226.17 | 17.09 | 349 | 41887 | 184542 | 90401669 |
| Ankle arthroplasty | 225.38 | 17.09 | 74 | 42162 | 2757 | 90583454 |
| Soft tissue disorder | 224.62 | 17.09 | 82 | 42154 | 4208 | 90582003 |
| Arthritis | 220.49 | 17.09 | 327 | 41909 | 166988 | 90419223 |
| Therapy non-responder | 218.41 | 17.09 | 293 | 41943 | 136411 | 90449800 |
| Cutaneous vasculitis | 216.17 | 17.09 | 92 | 42144 | 7101 | 90579110 |
| Liver function test abnormal | 213.04 | 17.09 | 182 | 42054 | 50663 | 90535548 |
| Contraindicated product administered | 211.70 | 17.09 | 463 | 41773 | 319676 | 90266535 |
| Rheumatoid factor positive | 200.15 | 17.09 | 317 | 41919 | 171333 | 90414878 |
| Condition aggravated | 197.19 | 17.09 | 667 | 41569 | 594878 | 89991333 |
| Hypocalcaemia | 174.11 | 17.09 | 150 | 42086 | 42218 | 90543993 |
| Fine motor skill dysfunction | 168.46 | 17.09 | 71 | 42165 | 5348 | 90580863 |
| Therapeutic product effect incomplete | 165.57 | 17.09 | 312 | 41924 | 193584 | 90392627 |
| Obesity | 163.68 | 17.09 | 223 | 42013 | 105284 | 90480927 |
| Antibody test positive | 163.45 | 17.09 | 59 | 42177 | 2930 | 90583281 |
| Treatment failure | 161.90 | 17.09 | 404 | 41832 | 303524 | 90282687 |
| Short stature | 158.14 | 17.09 | 45 | 42191 | 1025 | 90585186 |
| Drug specific antibody | 150.28 | 17.09 | 53 | 42183 | 2459 | 90583752 |
| Psoriasis | 148.12 | 17.09 | 255 | 41981 | 147499 | 90438712 |
| Arthropathy | 147.26 | 17.09 | 439 | 41797 | 365803 | 90220408 |
| Adenovirus infection | 135.19 | 17.09 | 58 | 42178 | 4564 | 90581647 |
| Pneumonia viral | 132.59 | 17.09 | 70 | 42166 | 8753 | 90577458 |
| Spinal stenosis | 132.29 | 17.09 | 89 | 42147 | 17335 | 90568876 |
| Limb discomfort | 131.13 | 17.09 | 122 | 42114 | 37938 | 90548273 |
| Hepatosplenic T-cell lymphoma | 129.79 | 17.09 | 35 | 42201 | 649 | 90585562 |
| Joint swelling | 129.52 | 17.09 | 520 | 41716 | 502780 | 90083431 |
| Drug hypersensitivity | 129.02 | 17.09 | 491 | 41745 | 463118 | 90123093 |
| Infection | 128.82 | 17.09 | 416 | 41820 | 361678 | 90224533 |
| Fall | 128.70 | 17.09 | 33 | 42203 | 481777 | 90104434 |
| Foot operation | 128.46 | 17.09 | 69 | 42167 | 8932 | 90577279 |
| Body tinea | 127.28 | 17.09 | 45 | 42191 | 2103 | 90584108 |
| Drug ineffective for unapproved indication | 127.03 | 17.09 | 156 | 42080 | 66488 | 90519723 |
| Foot deformity | 125.78 | 17.09 | 147 | 42089 | 59504 | 90526707 |
| Secretion discharge | 122.61 | 17.09 | 82 | 42154 | 15814 | 90570397 |
| Red blood cell sedimentation rate increased | 119.72 | 17.09 | 169 | 42067 | 82426 | 90503785 |
| Ankle operation | 118.51 | 17.09 | 39 | 42197 | 1463 | 90584748 |
| Growth failure | 118.37 | 17.09 | 29 | 42207 | 360 | 90585851 |
| Vasculitic rash | 112.81 | 17.09 | 37 | 42199 | 1373 | 90584838 |
| Quality of life decreased | 110.61 | 17.09 | 69 | 42167 | 11820 | 90574391 |
| Loss of personal independence in daily activities | 108.72 | 17.09 | 213 | 42023 | 135892 | 90450319 |
| Dyspnoea | 108.32 | 17.09 | 152 | 42084 | 880803 | 89705408 |
| Asthenia | 108.20 | 17.09 | 57 | 42179 | 533694 | 90052517 |
| Impaired quality of life | 107.58 | 17.09 | 88 | 42148 | 23056 | 90563155 |
| Inhibitory drug interaction | 106.93 | 17.09 | 44 | 42192 | 3119 | 90583092 |
| Immune effector cell-associated neurotoxicity syndrome | 104.76 | 17.09 | 52 | 42184 | 5716 | 90580495 |
| Serum ferritin increased | 103.71 | 17.09 | 56 | 42180 | 7325 | 90578886 |
| Rheumatoid arthritis | 103.22 | 17.09 | 387 | 41849 | 362227 | 90223984 |
| Epidural lipomatosis | 103.15 | 17.09 | 24 | 42212 | 235 | 90585976 |
| Pleural effusion | 102.78 | 17.09 | 186 | 42050 | 111805 | 90474406 |
| Headache | 101.01 | 17.09 | 154 | 42082 | 862592 | 89723619 |
| Infection susceptibility increased | 100.97 | 17.09 | 45 | 42191 | 3881 | 90582330 |
| Smear cervix abnormal | 100.45 | 17.09 | 42 | 42194 | 3100 | 90583111 |
| Confusional state | 100.16 | 17.09 | 28 | 42208 | 386177 | 90200034 |
| Juvenile idiopathic arthritis | 97.23 | 17.09 | 44 | 42192 | 3933 | 90582278 |
| Hypokalaemia | 93.76 | 17.09 | 196 | 42040 | 130920 | 90455291 |
| Pulmonary fibrosis | 92.92 | 17.09 | 174 | 42062 | 107329 | 90478882 |
| Hepatotoxicity | 88.46 | 17.09 | 108 | 42128 | 45734 | 90540477 |
| Arthrodesis | 85.48 | 17.09 | 37 | 42199 | 2975 | 90583236 |
| Serum amyloid A protein increased | 83.22 | 17.09 | 25 | 42211 | 692 | 90585519 |
| Infiltration anaesthesia | 82.41 | 17.09 | 19 | 42217 | 178 | 90586033 |
| Growth retardation | 82.04 | 17.09 | 31 | 42205 | 1752 | 90584459 |
| Constipation | 79.16 | 17.09 | 17 | 42219 | 280378 | 90305833 |
| Hepatitis | 78.71 | 17.09 | 128 | 42108 | 70611 | 90515600 |
| Clubbing | 78.29 | 17.09 | 22 | 42214 | 478 | 90585733 |
| Sinusitis | 73.44 | 17.09 | 34 | 42202 | 343054 | 90243157 |
| Glucose tolerance impaired | 73.41 | 17.09 | 46 | 42190 | 7939 | 90578272 |
| Anxiety | 72.26 | 17.09 | 27 | 42209 | 309745 | 90276466 |
| Weight decreased | 72.00 | 17.09 | 44 | 42192 | 379866 | 90206345 |
| Arthralgia | 71.53 | 17.09 | 612 | 41624 | 777910 | 89808301 |
| Varicella zoster virus infection | 70.55 | 17.09 | 35 | 42201 | 3842 | 90582369 |
| Hypoaesthesia | 67.46 | 17.09 | 31 | 42205 | 314179 | 90272032 |
| Leukopenia | 66.74 | 17.09 | 146 | 42090 | 100564 | 90485647 |
| Complications of bone marrow transplant | 65.98 | 17.09 | 19 | 42217 | 452 | 90585759 |
| Decreased appetite | 65.45 | 17.09 | 48 | 42188 | 376492 | 90209719 |
| Bone density increased | 65.33 | 17.09 | 22 | 42214 | 887 | 90585324 |
| Cushingoid | 64.66 | 17.09 | 47 | 42189 | 10348 | 90575863 |
| Hypertensive cardiomyopathy | 64.53 | 17.09 | 17 | 42219 | 287 | 90585924 |
| Sensitivity to weather change | 64.02 | 17.09 | 44 | 42192 | 8870 | 90577341 |
| Muscle spasms | 63.90 | 17.09 | 19 | 42217 | 251864 | 90334347 |
| Discomfort | 63.83 | 17.09 | 24 | 42212 | 274311 | 90311900 |
| Lower respiratory tract infection | 63.42 | 17.09 | 19 | 42217 | 250640 | 90335571 |
| Death | 62.99 | 17.09 | 72 | 42164 | 456479 | 90129732 |
| Shoulder arthroplasty | 62.44 | 17.09 | 33 | 42203 | 4133 | 90582078 |
| Epstein-Barr viraemia | 62.04 | 17.09 | 24 | 42212 | 1446 | 90584765 |
| Asthma | 61.92 | 17.09 | 18 | 42218 | 242142 | 90344069 |
| C-reactive protein abnormal | 60.08 | 17.09 | 162 | 42074 | 127267 | 90458944 |
| Viraemia | 59.09 | 17.09 | 24 | 42212 | 1645 | 90584566 |
| Interstitial lung disease | 59.07 | 17.09 | 118 | 42118 | 76287 | 90509924 |
| General physical health deterioration | 58.25 | 17.09 | 48 | 42188 | 355067 | 90231144 |
| Blister | 58.18 | 17.09 | 23 | 42213 | 254975 | 90331236 |
| Cough | 57.93 | 17.09 | 52 | 42184 | 368910 | 90217301 |
| Drug reaction with eosinophilia and systemic symptoms | 56.83 | 17.09 | 84 | 42152 | 42674 | 90543537 |
| Folliculitis | 54.47 | 17.09 | 14 | 42222 | 204339 | 90381872 |
| Joint effusion | 54.44 | 17.09 | 56 | 42180 | 19654 | 90566557 |
| Helicobacter infection | 54.20 | 17.09 | 19 | 42217 | 226831 | 90359380 |
| Poor quality sleep | 53.95 | 17.09 | 62 | 42174 | 24631 | 90561580 |
| Pneumonia | 53.72 | 17.09 | 138 | 42098 | 637921 | 89948290 |
| Injection site reaction | 52.71 | 17.09 | 126 | 42110 | 91954 | 90494257 |
| Cytokine release syndrome | 52.50 | 17.09 | 65 | 42171 | 27908 | 90558303 |
| Steroid dependence | 52.00 | 17.09 | 24 | 42212 | 2245 | 90583966 |
| Paraesthesia | 51.73 | 17.09 | 26 | 42210 | 250300 | 90335911 |
| Somnolence | 50.84 | 17.09 | 17 | 42219 | 209067 | 90377144 |
| Oral herpes | 50.64 | 17.09 | 70 | 42166 | 33454 | 90552757 |
| Dehydration | 50.54 | 17.09 | 14 | 42222 | 194433 | 90391778 |
| Duodenal ulcer perforation | 50.41 | 17.09 | 20 | 42216 | 221268 | 90364943 |
| Febrile neutropenia | 50.36 | 17.09 | 7 | 42229 | 158342 | 90427869 |
| Purpura | 50.17 | 17.09 | 47 | 42189 | 14731 | 90571480 |
| Fatigue | 50.17 | 17.09 | 324 | 41912 | 1153699 | 89432512 |
| Pain in extremity | 50.12 | 17.09 | 83 | 42153 | 450446 | 90135765 |
| Oedema peripheral | 50.06 | 17.09 | 29 | 42207 | 257886 | 90328325 |
| Graft versus host disease in gastrointestinal tract | 49.96 | 17.09 | 29 | 42207 | 4359 | 90581852 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 49.78 | 17.09 | 28 | 42208 | 3965 | 90582246 |
| Drug interaction | 49.65 | 17.09 | 34 | 42202 | 276419 | 90309792 |
| Epstein-Barr virus infection | 49.47 | 17.09 | 40 | 42196 | 10304 | 90575907 |
| Skin disorder | 48.62 | 17.09 | 72 | 42164 | 36634 | 90549577 |
| Irritable bowel syndrome | 48.49 | 17.09 | 18 | 42218 | 207430 | 90378781 |
| Impaired work ability | 48.20 | 17.09 | 52 | 42184 | 19274 | 90566937 |
| C-reactive protein increased | 47.73 | 17.09 | 189 | 42047 | 181200 | 90405011 |
| Hyponatraemia | 47.30 | 17.09 | 4 | 42232 | 133534 | 90452677 |
| Cytopenia | 47.16 | 17.09 | 49 | 42187 | 17400 | 90568811 |
| Clear cell renal cell carcinoma | 46.78 | 17.09 | 20 | 42216 | 1560 | 90584651 |
| Diaphragm muscle weakness | 46.20 | 17.09 | 9 | 42227 | 33 | 90586178 |
| Neuropathy peripheral | 46.14 | 17.09 | 5 | 42231 | 136965 | 90449246 |
| Palpitations | 46.04 | 17.09 | 5 | 42231 | 136723 | 90449488 |
| Wound | 46.01 | 17.09 | 44 | 42192 | 302936 | 90283275 |
| Wheezing | 45.88 | 17.09 | 27 | 42209 | 238053 | 90348158 |
| Cellulitis staphylococcal | 45.58 | 17.09 | 17 | 42219 | 926 | 90585285 |
| Infusion related reaction | 45.23 | 17.09 | 78 | 42158 | 416702 | 90169509 |
| Pruritus | 44.88 | 17.09 | 118 | 42118 | 541407 | 90044804 |
| Blood lactate dehydrogenase decreased | 44.32 | 17.09 | 12 | 42224 | 226 | 90585985 |
| Chest discomfort | 44.28 | 17.09 | 6 | 42230 | 138359 | 90447852 |
| Tremor | 43.79 | 17.09 | 9 | 42227 | 153164 | 90433047 |
| Overdose | 43.60 | 17.09 | 10 | 42226 | 157699 | 90428512 |
| Actinomycotic sepsis | 43.27 | 17.09 | 12 | 42224 | 248 | 90585963 |
| Hyperferritinaemia | 43.06 | 17.09 | 13 | 42223 | 366 | 90585845 |
| Dry mouth | 42.97 | 17.09 | 16 | 42220 | 184043 | 90402168 |
| Herpes zoster infection neurological | 42.34 | 17.09 | 14 | 42222 | 533 | 90585678 |
| Muscular weakness | 41.90 | 17.09 | 22 | 42214 | 206644 | 90379567 |
| Muscle injury | 41.84 | 17.09 | 15 | 42221 | 176639 | 90409572 |
| Hair follicle tumour benign | 41.81 | 17.09 | 13 | 42223 | 405 | 90585806 |
| Human anti-human antibody test | 41.50 | 17.09 | 13 | 42223 | 415 | 90585796 |
| Haemoglobin decreased | 41.46 | 17.09 | 12 | 42224 | 161944 | 90424267 |
| Hepatosplenomegaly | 39.97 | 17.09 | 22 | 42214 | 2987 | 90583224 |
| Joint arthroplasty | 39.64 | 17.09 | 23 | 42213 | 3454 | 90582757 |
| Nasopharyngitis | 39.08 | 17.09 | 82 | 42154 | 407022 | 90179189 |
| Memory impairment | 38.52 | 17.09 | 22 | 42214 | 197222 | 90388989 |
| Renal mass | 37.92 | 17.09 | 20 | 42216 | 2495 | 90583716 |
| Osteomyelitis | 37.43 | 17.09 | 55 | 42181 | 27791 | 90558420 |
| Adrenal suppression | 37.41 | 17.09 | 15 | 42221 | 994 | 90585217 |
| Autoinflammatory disease | 37.34 | 17.09 | 11 | 42225 | 284 | 90585927 |
| Injury | 37.15 | 17.09 | 23 | 42213 | 197326 | 90388885 |
| Endodontic procedure | 37.02 | 17.09 | 22 | 42214 | 3453 | 90582758 |
| Pericarditis | 36.79 | 17.09 | 43 | 42193 | 270108 | 90316103 |
| Parvovirus infection | 35.56 | 17.09 | 12 | 42224 | 487 | 90585724 |
| Myocardial infarction | 35.36 | 17.09 | 4 | 42232 | 105968 | 90480243 |
| Scar excision | 34.99 | 17.09 | 8 | 42228 | 72 | 90586139 |
| Graft versus host disease in skin | 34.93 | 17.09 | 22 | 42214 | 3831 | 90582380 |
| Chondrocalcinosis | 33.95 | 17.09 | 16 | 42220 | 1569 | 90584642 |
| Sleep disorder due to general medical condition, insomnia type | 33.94 | 17.09 | 9 | 42227 | 128685 | 90457526 |
| White blood cell count decreased | 33.56 | 17.09 | 18 | 42218 | 167091 | 90419120 |
| Abdominal discomfort | 33.06 | 17.09 | 113 | 42123 | 477215 | 90108996 |
| Acute graft versus host disease in skin | 33.03 | 17.09 | 23 | 42213 | 4733 | 90581478 |
| Stomatitis | 33.01 | 17.09 | 48 | 42188 | 274650 | 90311561 |
| Toxicity to various agents | 32.95 | 17.09 | 52 | 42184 | 287794 | 90298417 |
| Alveolar proteinosis | 32.40 | 17.09 | 13 | 42223 | 863 | 90585348 |
| Atrial fibrillation | 32.23 | 17.09 | 11 | 42225 | 133600 | 90452611 |
| Gastrooesophageal reflux disease | 31.84 | 17.09 | 19 | 42217 | 166318 | 90419893 |
| Hypertransaminasaemia | 31.69 | 17.09 | 38 | 42198 | 15787 | 90570424 |
| Fibromyalgia | 31.68 | 17.09 | 184 | 42052 | 206085 | 90380126 |
| Balance disorder | 31.56 | 17.09 | 4 | 42232 | 97076 | 90489135 |
| Bronchitis | 31.40 | 17.09 | 16 | 42220 | 152911 | 90433300 |
| Interleukin level increased | 31.23 | 17.09 | 12 | 42224 | 710 | 90585501 |
| Hepatic enzyme increased | 31.09 | 17.09 | 77 | 42159 | 360659 | 90225552 |
| Therapeutic response decreased | 30.81 | 17.09 | 102 | 42134 | 89627 | 90496584 |
| Focal nodular hyperplasia | 30.45 | 17.09 | 12 | 42224 | 760 | 90585451 |
| Hyperlipidaemia | 30.42 | 17.09 | 45 | 42191 | 22871 | 90563340 |
| Pneumonia lipoid | 30.32 | 17.09 | 8 | 42228 | 136 | 90586075 |
| Type 2 diabetes mellitus | 30.28 | 17.09 | 30 | 42206 | 203214 | 90382997 |
| Cerebrovascular accident | 30.09 | 17.09 | 10 | 42226 | 123523 | 90462688 |
| Demyelination | 29.79 | 17.09 | 27 | 42209 | 8113 | 90578098 |
| Human herpesvirus 6 infection | 29.62 | 17.09 | 19 | 42217 | 3413 | 90582798 |
| Skin fissures | 29.27 | 17.09 | 42 | 42194 | 20767 | 90565444 |
| Gait disturbance | 28.93 | 17.09 | 48 | 42188 | 260448 | 90325763 |
| Product dose omission issue | 28.61 | 17.09 | 58 | 42178 | 291629 | 90294582 |
| Intentional product use issue | 28.60 | 17.09 | 186 | 42050 | 216706 | 90369505 |
| Encephalitis viral | 28.42 | 17.09 | 15 | 42221 | 1874 | 90584337 |
| Chills | 28.33 | 17.09 | 13 | 42223 | 131968 | 90454243 |
| Pyrexia | 28.18 | 17.09 | 448 | 41788 | 660037 | 89926174 |
| Skin graft infection | 27.99 | 17.09 | 7 | 42229 | 95 | 90586116 |
| Fluid retention | 27.76 | 17.09 | 4 | 42232 | 88087 | 90498124 |
| Dry skin | 27.75 | 17.09 | 4 | 42232 | 88069 | 90498142 |
| Drug abuse | 27.75 | 17.09 | 3 | 42233 | 82344 | 90503867 |
| Inappropriate schedule of product administration | 27.49 | 17.09 | 18 | 42218 | 149915 | 90436296 |
| Cytomegalovirus viraemia | 27.44 | 17.09 | 25 | 42211 | 7561 | 90578650 |
| Toothache | 27.16 | 17.09 | 42 | 42194 | 22188 | 90564023 |
| Laryngeal stenosis | 27.10 | 17.09 | 13 | 42223 | 1326 | 90584885 |
| Myalgia | 27.07 | 17.09 | 25 | 42211 | 175100 | 90411111 |
| Alopecia | 26.84 | 17.09 | 129 | 42107 | 494942 | 90091269 |
| Lip dry | 26.73 | 17.09 | 7 | 42229 | 100948 | 90485263 |
| Muckle-Wells syndrome | 26.69 | 17.09 | 4 | 42232 | 0 | 90586211 |
| Gait inability | 26.29 | 17.09 | 18 | 42218 | 146438 | 90439773 |
| Hyperplasia | 26.10 | 17.09 | 12 | 42224 | 1112 | 90585099 |
| Joint injury | 25.90 | 17.09 | 51 | 42185 | 32613 | 90553598 |
| Platelet count decreased | 25.72 | 17.09 | 16 | 42220 | 136953 | 90449258 |
| Drug specific antibody present | 25.69 | 17.09 | 21 | 42215 | 5493 | 90580718 |
| Bacterial sepsis | 25.49 | 17.09 | 20 | 42216 | 4935 | 90581276 |
| Joint range of motion decreased | 25.26 | 17.09 | 16 | 42220 | 135627 | 90450584 |
| Spondyloarthropathy | 25.13 | 17.09 | 12 | 42224 | 1212 | 90584999 |
| Deep vein thrombosis | 24.94 | 17.09 | 6 | 42230 | 91614 | 90494597 |
| Borrelia infection | 24.44 | 17.09 | 8 | 42228 | 295 | 90585916 |
| Upper respiratory tract infection | 24.08 | 17.09 | 15 | 42221 | 128303 | 90457908 |
| Lymphodepletion | 23.94 | 17.09 | 5 | 42231 | 28 | 90586183 |
| Serum ferritin decreased | 23.88 | 17.09 | 15 | 42221 | 2599 | 90583612 |
| Thrombosis | 23.85 | 17.09 | 3 | 42233 | 73248 | 90512963 |
| Medical device site discomfort | 23.84 | 17.09 | 8 | 42228 | 319 | 90585892 |
| Soft tissue swelling | 23.78 | 17.09 | 12 | 42224 | 1366 | 90584845 |
| Renal failure | 23.65 | 17.09 | 16 | 42220 | 130991 | 90455220 |
| Nasal congestion | 23.63 | 17.09 | 5 | 42231 | 83409 | 90502802 |
| Rhinorrhoea | 23.62 | 17.09 | 6 | 42230 | 88310 | 90497901 |
| Exfoliative rash | 23.50 | 17.09 | 16 | 42220 | 3176 | 90583035 |
| Neck pain | 23.24 | 17.09 | 110 | 42126 | 113853 | 90472358 |
| Tumour necrosis factor receptor-associated periodic syndrome | 23.19 | 17.09 | 6 | 42230 | 94 | 90586117 |
| Breast ulceration | 22.99 | 17.09 | 7 | 42229 | 203 | 90586008 |
| Diffuse large B-cell lymphoma | 22.86 | 17.09 | 24 | 42212 | 8621 | 90577590 |
| Back disorder | 22.77 | 17.09 | 42 | 42194 | 25589 | 90560622 |
| Symptom recurrence | 22.60 | 17.09 | 17 | 42219 | 3942 | 90582269 |
| Guillain-Barre syndrome | 22.41 | 17.09 | 18 | 42218 | 4594 | 90581617 |
| Cognitive disorder | 22.22 | 17.09 | 3 | 42233 | 69404 | 90516807 |
| Vision blurred | 21.96 | 17.09 | 12 | 42224 | 110281 | 90475930 |
| Fasciitis | 21.95 | 17.09 | 9 | 42227 | 632 | 90585579 |
| Incorrect dose administered | 21.82 | 17.09 | 5 | 42231 | 78925 | 90507286 |
| Product use issue | 21.61 | 17.09 | 242 | 41994 | 329677 | 90256534 |
| Hyperhidrosis | 21.61 | 17.09 | 19 | 42217 | 136286 | 90449925 |
| Inflammatory marker increased | 21.60 | 17.09 | 24 | 42212 | 9190 | 90577021 |
| Post transplant lymphoproliferative disorder | 21.50 | 17.09 | 21 | 42215 | 6928 | 90579283 |
| Urinary tract infection | 21.37 | 17.09 | 72 | 42164 | 305560 | 90280651 |
| Bursitis | 21.30 | 17.09 | 18 | 42218 | 131636 | 90454575 |
| Migraine | 21.21 | 17.09 | 35 | 42201 | 190357 | 90395854 |
| Obliterative bronchiolitis | 21.08 | 17.09 | 14 | 42222 | 2667 | 90583544 |
| Blood glucose increased | 21.04 | 17.09 | 9 | 42227 | 95237 | 90490974 |
| Embolism | 21.04 | 17.09 | 24 | 42212 | 9457 | 90576754 |
| Ankylosing spondylitis | 20.70 | 17.09 | 28 | 42208 | 13105 | 90573106 |
| Dyspepsia | 20.64 | 17.09 | 38 | 42198 | 198122 | 90388089 |
| Chest pain | 20.56 | 17.09 | 78 | 42158 | 319567 | 90266644 |
| Hodgkin's disease | 20.51 | 17.09 | 9 | 42227 | 748 | 90585463 |
| Lower limb fracture | 20.50 | 17.09 | 7 | 42229 | 85006 | 90501205 |
| Gastrointestinal disorder | 20.42 | 17.09 | 57 | 42179 | 256630 | 90329581 |
| Bradycardia | 20.05 | 17.09 | 7 | 42229 | 83840 | 90502371 |
| Impaired gastric emptying | 19.72 | 17.09 | 27 | 42209 | 12782 | 90573429 |
| Road traffic accident | 19.62 | 17.09 | 13 | 42223 | 107613 | 90478598 |
| Oxygen saturation decreased | 19.57 | 17.09 | 13 | 42223 | 107470 | 90478741 |
| Liver disorder | 19.11 | 17.09 | 17 | 42219 | 121252 | 90464959 |
| Blau syndrome | 19.06 | 17.09 | 4 | 42232 | 23 | 90586188 |
| Agitation | 19.05 | 17.09 | 4 | 42232 | 67094 | 90519117 |
| Vitiligo | 19.01 | 17.09 | 12 | 42224 | 2098 | 90584113 |
| Mouth ulceration | 19.00 | 17.09 | 51 | 42185 | 39923 | 90546288 |
| Amyloidosis | 18.97 | 17.09 | 10 | 42226 | 1246 | 90584965 |
| Wrong technique in product usage process | 18.88 | 17.09 | 5 | 42231 | 71566 | 90514645 |
| Epistaxis | 18.87 | 17.09 | 8 | 42228 | 85117 | 90501094 |
| Respiratory acidosis | 18.78 | 17.09 | 21 | 42215 | 8098 | 90578113 |
| BK virus infection | 18.62 | 17.09 | 16 | 42220 | 4482 | 90581729 |
| Haematochezia | 18.62 | 17.09 | 5 | 42231 | 70908 | 90515303 |
| Autoimmune thyroiditis | 18.59 | 17.09 | 18 | 42218 | 5875 | 90580336 |
| Suicide attempt | 18.54 | 17.09 | 6 | 42230 | 75393 | 90510818 |
| Periodontal inflammation | 18.26 | 17.09 | 4 | 42232 | 29 | 90586182 |
| Swollen joint count increased | 18.24 | 17.09 | 15 | 42221 | 111191 | 90475020 |
| Erythema | 18.16 | 17.09 | 51 | 42185 | 229195 | 90357016 |
| Hypofibrinogenaemia | 18.15 | 17.09 | 10 | 42226 | 1360 | 90584851 |
| Seizure | 18.00 | 17.09 | 27 | 42209 | 152602 | 90433609 |
| Rectal haemorrhage | 17.99 | 17.09 | 8 | 42228 | 82736 | 90503475 |
| Secondary adrenocortical insufficiency | 17.97 | 17.09 | 12 | 42224 | 2306 | 90583905 |
| Blood creatine phosphokinase decreased | 17.90 | 17.09 | 8 | 42228 | 694 | 90585517 |
| Facet joint syndrome | 17.78 | 17.09 | 12 | 42224 | 98377 | 90487834 |
| Cytomegalovirus infection reactivation | 17.74 | 17.09 | 20 | 42216 | 7780 | 90578431 |
| Heart rate increased | 17.59 | 17.09 | 16 | 42220 | 112886 | 90473325 |
| Haematological malignancy | 17.56 | 17.09 | 7 | 42229 | 457 | 90585754 |
| Swelling face | 17.48 | 17.09 | 8 | 42228 | 81344 | 90504867 |
| Unwanted pregnancy | 17.36 | 17.09 | 5 | 42231 | 119 | 90586092 |
| Amnesia | 17.35 | 17.09 | 15 | 42221 | 108490 | 90477721 |
| Mucosal inflammation | 17.29 | 17.09 | 3 | 42233 | 57622 | 90528589 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Apparent death | 978.98 | 29.56 | 231 | 14061 | 3477 | 42603566 |
| Off label use | 777.96 | 29.56 | 1000 | 13292 | 637335 | 41969708 |
| Diverticulitis | 649.42 | 29.56 | 255 | 14037 | 22518 | 42584525 |
| Drug ineffective | 425.70 | 29.56 | 753 | 13539 | 629444 | 41977599 |
| Joint swelling | 402.41 | 29.56 | 262 | 14030 | 67760 | 42539283 |
| Deep vein thrombosis | 373.02 | 29.56 | 262 | 14030 | 76695 | 42530348 |
| Pulmonary thrombosis | 368.49 | 29.56 | 129 | 14163 | 8219 | 42598824 |
| Red blood cell sedimentation rate increased | 357.74 | 29.56 | 132 | 14160 | 9792 | 42597251 |
| Terminal state | 293.65 | 29.56 | 93 | 14199 | 4330 | 42602713 |
| Haemophagocytic lymphohistiocytosis | 277.20 | 29.56 | 131 | 14161 | 18091 | 42588952 |
| Renal failure | 273.48 | 29.56 | 286 | 14006 | 143440 | 42463603 |
| Pulmonary embolism | 254.68 | 29.56 | 253 | 14039 | 119359 | 42487684 |
| C-reactive protein abnormal | 243.70 | 29.56 | 98 | 14194 | 9163 | 42597880 |
| Acne cystic | 178.50 | 29.56 | 41 | 14251 | 541 | 42606502 |
| Contraindicated product administered | 175.69 | 29.56 | 108 | 14184 | 25164 | 42581879 |
| Drug ineffective for unapproved indication | 175.54 | 29.56 | 136 | 14156 | 46027 | 42561016 |
| Drug specific antibody present | 173.23 | 29.56 | 61 | 14231 | 3945 | 42603098 |
| Intestinal sepsis | 152.93 | 29.56 | 38 | 14254 | 713 | 42606330 |
| Pain | 149.48 | 29.56 | 282 | 14010 | 244566 | 42362477 |
| Joint arthroplasty | 147.78 | 29.56 | 39 | 14253 | 938 | 42606105 |
| Photosensitivity reaction | 147.44 | 29.56 | 76 | 14216 | 12626 | 42594417 |
| Thrombosis | 134.67 | 29.56 | 139 | 14153 | 68372 | 42538671 |
| Interleukin level increased | 131.33 | 29.56 | 35 | 14257 | 875 | 42606168 |
| C-reactive protein increased | 121.38 | 29.56 | 127 | 14165 | 63433 | 42543610 |
| Sepsis | 112.17 | 29.56 | 222 | 14070 | 199112 | 42407931 |
| Drug reaction with eosinophilia and systemic symptoms | 94.82 | 29.56 | 92 | 14200 | 41983 | 42565060 |
| Drug intolerance | 94.01 | 29.56 | 125 | 14167 | 80299 | 42526744 |
| Cytokine release syndrome | 92.26 | 29.56 | 93 | 14199 | 44434 | 42562609 |
| Monocyte chemotactic protein-1 increased | 92.17 | 29.56 | 22 | 14270 | 346 | 42606697 |
| Alpha tumour necrosis factor increased | 91.88 | 29.56 | 22 | 14270 | 351 | 42606692 |
| Herpes zoster | 91.37 | 29.56 | 87 | 14205 | 38790 | 42568253 |
| Gait inability | 90.49 | 29.56 | 69 | 14223 | 22764 | 42584279 |
| Drug use disorder | 89.69 | 29.56 | 51 | 14241 | 10282 | 42596761 |
| Treatment failure | 88.49 | 29.56 | 107 | 14185 | 62517 | 42544526 |
| Immune effector cell-associated neurotoxicity syndrome | 82.93 | 29.56 | 47 | 14245 | 9414 | 42597629 |
| Dyspnoea | 81.24 | 29.56 | 24 | 14268 | 442597 | 42164446 |
| Arthropathy | 80.74 | 29.56 | 72 | 14220 | 29525 | 42577518 |
| Stent placement | 79.79 | 29.56 | 38 | 14254 | 5322 | 42601721 |
| Intentional product use issue | 78.38 | 29.56 | 108 | 14184 | 71725 | 42535318 |
| Stomatitis | 72.73 | 29.56 | 87 | 14205 | 50242 | 42556801 |
| Urticaria | 71.47 | 29.56 | 105 | 14187 | 73931 | 42533112 |
| Diarrhoea | 71.11 | 29.56 | 33 | 14259 | 460816 | 42146227 |
| Injection site reaction | 70.09 | 29.56 | 51 | 14241 | 15670 | 42591373 |
| Knee arthroplasty | 64.75 | 29.56 | 39 | 14253 | 8742 | 42598301 |
| Interstitial lung disease | 64.09 | 29.56 | 103 | 14189 | 78359 | 42528684 |
| Drug hypersensitivity | 63.50 | 29.56 | 117 | 14175 | 99272 | 42507771 |
| Propionibacterium infection | 62.78 | 29.56 | 15 | 14277 | 237 | 42606806 |
| Meningitis viral | 60.16 | 29.56 | 20 | 14272 | 1085 | 42605958 |
| Systemic candida | 56.49 | 29.56 | 30 | 14262 | 5289 | 42601754 |
| Spinal cord injury cervical | 55.39 | 29.56 | 14 | 14278 | 282 | 42606761 |
| Drug interaction | 53.63 | 29.56 | 12 | 14280 | 266987 | 42340056 |
| Fatigue | 52.11 | 29.56 | 42 | 14250 | 435599 | 42171444 |
| Condition aggravated | 50.88 | 29.56 | 197 | 14095 | 260557 | 42346486 |
| Serum ferritin increased | 50.50 | 29.56 | 31 | 14261 | 7188 | 42599855 |
| Rebound effect | 49.87 | 29.56 | 31 | 14261 | 7348 | 42599695 |
| Immobilisation syndrome | 48.80 | 29.56 | 14 | 14278 | 462 | 42606581 |
| Dizziness | 46.57 | 29.56 | 13 | 14279 | 249241 | 42357802 |
| Multiple-drug resistance | 45.08 | 29.56 | 29 | 14263 | 7293 | 42599750 |
| Cytomegalovirus hepatitis | 42.91 | 29.56 | 13 | 14279 | 520 | 42606523 |
| Serum amyloid A protein increased | 41.81 | 29.56 | 11 | 14281 | 261 | 42606782 |
| Drug dependence | 41.52 | 29.56 | 50 | 14242 | 29044 | 42577999 |
| Therapeutic product effect decreased | 41.37 | 29.56 | 58 | 14234 | 39092 | 42567951 |
| Central nervous system lymphoma | 41.11 | 29.56 | 16 | 14276 | 1369 | 42605674 |
| Disseminated mucormycosis | 41.04 | 29.56 | 16 | 14276 | 1375 | 42605668 |
| Oral fungal infection | 40.17 | 29.56 | 17 | 14275 | 1804 | 42605239 |
| Testicular seminoma (pure) | 39.68 | 29.56 | 10 | 14282 | 199 | 42606844 |
| Feeling abnormal | 39.41 | 29.56 | 78 | 14214 | 69708 | 42537335 |
| Septic shock | 38.63 | 29.56 | 91 | 14201 | 91581 | 42515462 |
| Streptococcal infection | 37.05 | 29.56 | 24 | 14268 | 6108 | 42600935 |
| Product use in unapproved indication | 36.43 | 29.56 | 140 | 14152 | 184316 | 42422727 |
| Myocardial infarction | 35.86 | 29.56 | 107 | 14185 | 123902 | 42483141 |
| Rheumatoid arthritis | 35.01 | 29.56 | 56 | 14236 | 42384 | 42564659 |
| Post transplant lymphoproliferative disorder | 34.89 | 29.56 | 27 | 14265 | 9093 | 42597950 |
| Decreased appetite | 34.36 | 29.56 | 11 | 14281 | 193126 | 42413917 |
| Hyperferritinaemia | 33.17 | 29.56 | 11 | 14281 | 592 | 42606451 |
| Opportunistic infection | 32.28 | 29.56 | 15 | 14277 | 1986 | 42605057 |
| Glucose tolerance impaired | 32.18 | 29.56 | 19 | 14273 | 4105 | 42602938 |
| Varicella | 31.83 | 29.56 | 15 | 14277 | 2050 | 42604993 |
| Fall | 31.38 | 29.56 | 20 | 14272 | 234500 | 42372543 |
| Somnolence | 31.14 | 29.56 | 5 | 14287 | 141100 | 42465943 |
| Alveolar proteinosis | 31.11 | 29.56 | 11 | 14281 | 719 | 42606324 |
| Fungal skin infection | 30.36 | 29.56 | 17 | 14275 | 3324 | 42603719 |
| Inflammatory marker increased | 30.29 | 29.56 | 22 | 14270 | 6734 | 42600309 |
| Multiple organ dysfunction syndrome | 30.23 | 29.56 | 86 | 14206 | 96949 | 42510094 |
| Cytomegalovirus infection reactivation | 30.08 | 29.56 | 27 | 14265 | 11151 | 42595892 |
| Cytopenia | 29.89 | 29.56 | 33 | 14259 | 17464 | 42589579 |
| Bradycardia foetal | 29.78 | 29.56 | 9 | 14283 | 357 | 42606686 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Off label use | 928.07 | 16.39 | 1942 | 43322 | 1498243 | 109045792 |
| Drug ineffective | 883.26 | 16.39 | 1919 | 43345 | 1518621 | 109025414 |
| Haemophagocytic lymphohistiocytosis | 676.37 | 16.39 | 306 | 44958 | 31253 | 110512782 |
| Red blood cell sedimentation rate abnormal | 636.41 | 16.39 | 272 | 44992 | 24237 | 110519798 |
| Polyarthritis | 471.05 | 16.39 | 204 | 45060 | 18759 | 110525276 |
| Joint destruction | 406.16 | 16.39 | 157 | 45107 | 10786 | 110533249 |
| Drug intolerance | 382.95 | 16.39 | 634 | 44630 | 405878 | 110138157 |
| Apparent death | 353.49 | 16.39 | 102 | 45162 | 2800 | 110541235 |
| Contraindicated product administered | 342.22 | 16.39 | 463 | 44801 | 247804 | 110296231 |
| Adrenal insufficiency | 328.90 | 16.39 | 209 | 45055 | 42181 | 110501854 |
| Human antichimeric antibody positive | 317.39 | 16.39 | 84 | 45180 | 1658 | 110542377 |
| Red blood cell sedimentation rate increased | 316.91 | 16.39 | 260 | 45004 | 78042 | 110465993 |
| Oral mucosal exfoliation | 308.18 | 16.39 | 81 | 45183 | 1555 | 110542480 |
| Body height below normal | 302.48 | 16.39 | 84 | 45180 | 2000 | 110542035 |
| Therapeutic product effect decreased | 275.27 | 16.39 | 414 | 44850 | 243902 | 110300133 |
| Bone density decreased | 267.86 | 16.39 | 131 | 45133 | 15911 | 110528124 |
| Drug ineffective for unapproved indication | 252.39 | 16.39 | 258 | 45006 | 102580 | 110441455 |
| Synovitis | 250.34 | 16.39 | 422 | 44842 | 273670 | 110270365 |
| Wheelchair user | 247.21 | 16.39 | 100 | 45164 | 7742 | 110536293 |
| Treatment failure | 246.81 | 16.39 | 422 | 44842 | 276812 | 110267223 |
| Joint swelling | 231.09 | 16.39 | 539 | 44725 | 442306 | 110101729 |
| Pulmonary thrombosis | 227.85 | 16.39 | 112 | 45152 | 13751 | 110530284 |
| Herpes zoster | 227.11 | 16.39 | 250 | 45014 | 108129 | 110435906 |
| Arthropathy | 224.16 | 16.39 | 413 | 44851 | 287109 | 110256926 |
| Terminal state | 219.91 | 16.39 | 84 | 45180 | 5583 | 110538452 |
| Septic shock | 217.14 | 16.39 | 294 | 44970 | 157234 | 110386801 |
| Immunodeficiency | 216.38 | 16.39 | 156 | 45108 | 38682 | 110505353 |
| Rheumatoid factor positive | 213.11 | 16.39 | 266 | 44998 | 131374 | 110412661 |
| Condition aggravated | 212.99 | 16.39 | 722 | 44542 | 734114 | 109809921 |
| Drug tolerance | 192.21 | 16.39 | 106 | 45158 | 16479 | 110527556 |
| Gastroenteritis viral | 186.81 | 16.39 | 131 | 45133 | 31095 | 110512940 |
| Therapy non-responder | 184.79 | 16.39 | 272 | 44992 | 157035 | 110387000 |
| C-reactive protein abnormal | 184.73 | 16.39 | 246 | 45018 | 129449 | 110414586 |
| Rheumatoid arthritis | 184.64 | 16.39 | 390 | 44874 | 299223 | 110244812 |
| Cutaneous vasculitis | 183.21 | 16.39 | 94 | 45170 | 12635 | 110531400 |
| Nodule | 181.61 | 16.39 | 131 | 45133 | 32500 | 110511535 |
| Ankle arthroplasty | 164.11 | 16.39 | 55 | 45209 | 2496 | 110541539 |
| Deformity | 163.74 | 16.39 | 81 | 45183 | 10079 | 110533956 |
| Drug hypersensitivity | 161.29 | 16.39 | 479 | 44785 | 453611 | 110090424 |
| Immune effector cell-associated neurotoxicity syndrome | 159.10 | 16.39 | 90 | 45174 | 14692 | 110529343 |
| Dyspnoea | 156.94 | 16.39 | 134 | 45130 | 1106738 | 109437297 |
| Drug specific antibody | 154.70 | 16.39 | 54 | 45210 | 2774 | 110541261 |
| Musculoskeletal disorder | 154.32 | 16.39 | 103 | 45161 | 22561 | 110521474 |
| Fine motor skill dysfunction | 154.14 | 16.39 | 67 | 45197 | 6207 | 110537828 |
| Arthritis | 147.50 | 16.39 | 254 | 45010 | 167332 | 110376703 |
| Drug specific antibody present | 147.19 | 16.39 | 71 | 45193 | 8363 | 110535672 |
| Joint arthroplasty | 139.29 | 16.39 | 53 | 45211 | 3484 | 110540551 |
| Antibody test positive | 138.36 | 16.39 | 51 | 45213 | 3069 | 110540966 |
| Cytokine release syndrome | 138.34 | 16.39 | 157 | 45107 | 70149 | 110473886 |
| Fall | 136.50 | 16.39 | 39 | 45225 | 603443 | 109940592 |
| Short stature | 135.93 | 16.39 | 39 | 45225 | 1048 | 110542987 |
| Diverticulitis | 134.37 | 16.39 | 136 | 45128 | 53386 | 110490649 |
| Body tinea | 129.74 | 16.39 | 44 | 45220 | 2071 | 110541964 |
| Mobility decreased | 126.86 | 16.39 | 292 | 44972 | 237130 | 110306905 |
| C-reactive protein increased | 121.96 | 16.39 | 273 | 44991 | 217646 | 110326389 |
| Soft tissue disorder | 121.70 | 16.39 | 48 | 45216 | 3476 | 110540559 |
| Loss of consciousness | 120.19 | 16.39 | 255 | 45009 | 196051 | 110347984 |
| Obesity | 117.50 | 16.39 | 185 | 45079 | 113166 | 110430869 |
| Interleukin level increased | 116.50 | 16.39 | 38 | 45226 | 1583 | 110542452 |
| Spinal stenosis | 116.43 | 16.39 | 81 | 45183 | 18975 | 110525060 |
| Secretion discharge | 112.02 | 16.39 | 81 | 45183 | 20163 | 110523872 |
| Psoriasis | 108.79 | 16.39 | 201 | 45063 | 139792 | 110404243 |
| Foot deformity | 108.77 | 16.39 | 116 | 45148 | 48364 | 110495671 |
| Foot operation | 108.13 | 16.39 | 55 | 45209 | 7258 | 110536777 |
| Smear cervix abnormal | 108.11 | 16.39 | 41 | 45223 | 2671 | 110541364 |
| Ill-defined disorder | 108.10 | 16.39 | 214 | 45050 | 156639 | 110387396 |
| Intestinal sepsis | 107.78 | 16.39 | 32 | 45232 | 972 | 110543063 |
| Confusional state | 104.62 | 16.39 | 31 | 45233 | 468649 | 110075386 |
| Therapeutic product effect incomplete | 104.20 | 16.39 | 261 | 45003 | 223544 | 110320491 |
| Ankle operation | 101.67 | 16.39 | 33 | 45231 | 1353 | 110542682 |
| Serum amyloid A protein increased | 101.02 | 16.39 | 30 | 45234 | 912 | 110543123 |
| Infection susceptibility increased | 98.46 | 16.39 | 44 | 45220 | 4354 | 110539681 |
| Hypocalcaemia | 97.67 | 16.39 | 127 | 45137 | 65239 | 110478796 |
| Vasculitic rash | 96.80 | 16.39 | 36 | 45228 | 2221 | 110541814 |
| Liver function test abnormal | 93.86 | 16.39 | 128 | 45136 | 68822 | 110475213 |
| Interstitial lung disease | 93.48 | 16.39 | 188 | 45076 | 139146 | 110404889 |
| Anxiety | 92.78 | 16.39 | 15 | 45249 | 345063 | 110198972 |
| Juvenile idiopathic arthritis | 91.22 | 16.39 | 46 | 45218 | 5961 | 110538074 |
| Inhibitory drug interaction | 90.44 | 16.39 | 43 | 45221 | 4904 | 110539131 |
| Drug interaction | 90.32 | 16.39 | 46 | 45218 | 500137 | 110043898 |
| Pneumonia viral | 88.97 | 16.39 | 56 | 45208 | 11101 | 110532934 |
| Monocyte chemotactic protein-1 increased | 87.80 | 16.39 | 22 | 45242 | 346 | 110543689 |
| Infection | 87.56 | 16.39 | 336 | 44928 | 361864 | 110182171 |
| Constipation | 86.80 | 16.39 | 20 | 45244 | 357766 | 110186269 |
| Hepatosplenic T-cell lymphoma | 86.34 | 16.39 | 27 | 45237 | 980 | 110543055 |
| Alpha tumour necrosis factor increased | 85.34 | 16.39 | 22 | 45242 | 390 | 110543645 |
| Toxicity to various agents | 84.10 | 16.39 | 46 | 45218 | 480509 | 110063526 |
| Drug reaction with eosinophilia and systemic symptoms | 83.69 | 16.39 | 133 | 45131 | 81962 | 110462073 |
| Serum ferritin increased | 83.45 | 16.39 | 55 | 45209 | 11792 | 110532243 |
| Limb discomfort | 81.65 | 16.39 | 92 | 45172 | 40762 | 110503273 |
| Quality of life decreased | 81.39 | 16.39 | 58 | 45206 | 14111 | 110529924 |
| Impaired quality of life | 80.35 | 16.39 | 79 | 45185 | 29938 | 110514097 |
| Asthenia | 76.64 | 16.39 | 102 | 45162 | 688897 | 109855138 |
| Infiltration anaesthesia | 76.15 | 16.39 | 17 | 45247 | 157 | 110543878 |
| Hyponatraemia | 72.75 | 16.39 | 4 | 45260 | 217649 | 110326386 |
| Decreased appetite | 71.71 | 16.39 | 54 | 45210 | 475792 | 110068243 |
| Somnolence | 69.46 | 16.39 | 18 | 45246 | 297431 | 110246604 |
| Intentional product use issue | 69.16 | 16.39 | 241 | 45023 | 247665 | 110296370 |
| Loss of personal independence in daily activities | 68.78 | 16.39 | 174 | 45090 | 149846 | 110394189 |
| Glucose tolerance impaired | 67.67 | 16.39 | 45 | 45219 | 9792 | 110534243 |
| Bone density increased | 66.18 | 16.39 | 22 | 45242 | 973 | 110543062 |
| Oedema peripheral | 65.92 | 16.39 | 26 | 45238 | 328634 | 110215401 |
| Photosensitivity reaction | 64.17 | 16.39 | 65 | 45199 | 25524 | 110518511 |
| Joint effusion | 63.51 | 16.39 | 59 | 45205 | 20846 | 110523189 |
| Cough | 62.64 | 16.39 | 58 | 45206 | 461583 | 110082452 |
| Hepatitis | 62.17 | 16.39 | 123 | 45141 | 89931 | 110454104 |
| Complications of bone marrow transplant | 62.14 | 16.39 | 19 | 45245 | 639 | 110543396 |
| General physical health deterioration | 61.87 | 16.39 | 50 | 45214 | 425245 | 110118790 |
| Overdose | 60.98 | 16.39 | 11 | 45253 | 233783 | 110310252 |
| Muscle spasms | 60.93 | 16.39 | 19 | 45245 | 278138 | 110265897 |
| Hyperferritinaemia | 60.47 | 16.39 | 21 | 45243 | 1062 | 110542973 |
| Paraesthesia | 60.37 | 16.39 | 19 | 45245 | 276502 | 110267533 |
| Injection site reaction | 58.31 | 16.39 | 119 | 45145 | 88951 | 110455084 |
| Hypoaesthesia | 58.04 | 16.39 | 28 | 45236 | 314195 | 110229840 |
| Propionibacterium infection | 57.41 | 16.39 | 15 | 45249 | 281 | 110543754 |
| Pulmonary fibrosis | 57.20 | 16.39 | 128 | 45136 | 101914 | 110442121 |
| Arthrodesis | 57.06 | 16.39 | 26 | 45238 | 2692 | 110541343 |
| Asthma | 56.82 | 16.39 | 16 | 45248 | 250275 | 110293760 |
| Post transplant lymphoproliferative disorder | 55.20 | 16.39 | 48 | 45216 | 15565 | 110528470 |
| Pleural effusion | 55.06 | 16.39 | 179 | 45085 | 177530 | 110366505 |
| Dehydration | 54.60 | 16.39 | 23 | 45241 | 279488 | 110264547 |
| Fatigue | 54.31 | 16.39 | 285 | 44979 | 1215673 | 109328362 |
| Systemic candida | 53.12 | 16.39 | 39 | 45225 | 9935 | 110534100 |
| Palpitations | 52.97 | 16.39 | 3 | 45261 | 159209 | 110384826 |
| Diffuse large B-cell lymphoma | 52.46 | 16.39 | 47 | 45217 | 15851 | 110528184 |
| Weight decreased | 52.28 | 16.39 | 69 | 45195 | 467988 | 110076047 |
| Pneumonia | 52.28 | 16.39 | 184 | 45080 | 876530 | 109667505 |
| Cytopenia | 52.13 | 16.39 | 63 | 45201 | 30053 | 110513982 |
| Pruritus | 50.65 | 16.39 | 101 | 45163 | 581459 | 109962576 |
| Malignant neoplasm progression | 50.63 | 16.39 | 6 | 45258 | 174561 | 110369474 |
| Headache | 50.10 | 16.39 | 189 | 45075 | 882188 | 109661847 |
| Tremor | 49.63 | 16.39 | 11 | 45253 | 202221 | 110341814 |
| Lower respiratory tract infection | 49.12 | 16.39 | 19 | 45245 | 243087 | 110300948 |
| Poor quality sleep | 49.04 | 16.39 | 59 | 45205 | 28018 | 110516017 |
| Death | 48.44 | 16.39 | 137 | 45127 | 698732 | 109845303 |
| Chest discomfort | 47.97 | 16.39 | 7 | 45257 | 173841 | 110370194 |
| Epstein-Barr virus infection | 47.72 | 16.39 | 48 | 45216 | 18690 | 110525345 |
| Neuropathy peripheral | 47.70 | 16.39 | 8 | 45256 | 179269 | 110364766 |
| Steroid dependence | 47.11 | 16.39 | 34 | 45230 | 8435 | 110535600 |
| Varicella zoster virus infection | 45.91 | 16.39 | 30 | 45234 | 6338 | 110537697 |
| Skin disorder | 45.77 | 16.39 | 71 | 45193 | 42842 | 110501193 |
| Drug use disorder | 45.48 | 16.39 | 46 | 45218 | 18028 | 110526007 |
| Cushingoid | 45.48 | 16.39 | 38 | 45226 | 11674 | 110532361 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 45.23 | 16.39 | 28 | 45236 | 5389 | 110538646 |
| Product use issue | 44.59 | 16.39 | 248 | 45016 | 311447 | 110232588 |
| Cerebrovascular accident | 44.20 | 16.39 | 10 | 45254 | 181274 | 110362761 |
| Knee arthroplasty | 43.97 | 16.39 | 88 | 45176 | 64860 | 110479175 |
| Human anti-human antibody test | 43.69 | 16.39 | 13 | 45251 | 398 | 110543637 |
| Rebound effect | 43.46 | 16.39 | 41 | 45223 | 14765 | 110529270 |
| Dry mouth | 43.17 | 16.39 | 14 | 45250 | 199934 | 110344101 |
| Alveolar proteinosis | 43.01 | 16.39 | 18 | 45246 | 1518 | 110542517 |
| Sinusitis | 42.98 | 16.39 | 35 | 45229 | 296653 | 110247382 |
| Growth retardation | 42.84 | 16.39 | 21 | 45243 | 2561 | 110541474 |
| Febrile neutropenia | 42.70 | 16.39 | 40 | 45224 | 316727 | 110227308 |
| Clubbing | 42.61 | 16.39 | 15 | 45249 | 790 | 110543245 |
| Stent placement | 42.44 | 16.39 | 30 | 45234 | 7204 | 110536831 |
| Hair follicle tumour benign | 42.35 | 16.39 | 13 | 45251 | 443 | 110543592 |
| Endodontic procedure | 41.80 | 16.39 | 22 | 45242 | 3114 | 110540921 |
| Thrombosis | 41.67 | 16.39 | 118 | 45146 | 108544 | 110435491 |
| Meningitis viral | 41.27 | 16.39 | 20 | 45244 | 2379 | 110541656 |
| Disseminated mucormycosis | 40.67 | 16.39 | 19 | 45245 | 2083 | 110541952 |
| Platelet count decreased | 40.35 | 16.39 | 22 | 45242 | 230421 | 110313614 |
| Oral herpes | 40.32 | 16.39 | 61 | 45203 | 36019 | 110508016 |
| Wheezing | 39.66 | 16.39 | 28 | 45236 | 255202 | 110288833 |
| Cytomegalovirus infection reactivation | 39.59 | 16.39 | 43 | 45221 | 18290 | 110525745 |
| Shoulder arthroplasty | 38.91 | 16.39 | 22 | 45242 | 3585 | 110540450 |
| Clear cell renal cell carcinoma | 38.64 | 16.39 | 20 | 45244 | 2736 | 110541299 |
| Cellulitis staphylococcal | 37.81 | 16.39 | 16 | 45248 | 1387 | 110542648 |
| Actinomycotic sepsis | 37.65 | 16.39 | 10 | 45254 | 200 | 110543835 |
| Impaired work ability | 37.39 | 16.39 | 50 | 45214 | 26369 | 110517666 |
| Adenovirus infection | 37.26 | 16.39 | 33 | 45231 | 10961 | 110533074 |
| Transplant failure | 36.89 | 16.39 | 25 | 45239 | 5610 | 110538425 |
| Discomfort | 36.87 | 16.39 | 21 | 45243 | 214686 | 110329349 |
| Arthralgia | 36.61 | 16.39 | 483 | 44781 | 779149 | 109764886 |
| Herpes zoster infection neurological | 36.51 | 16.39 | 12 | 45252 | 512 | 110543523 |
| Pain in extremity | 36.35 | 16.39 | 92 | 45172 | 487026 | 110057009 |
| Hyperkalaemia | 36.25 | 16.39 | 6 | 45258 | 135790 | 110408245 |
| Scar excision | 36.22 | 16.39 | 8 | 45256 | 70 | 110543965 |
| Multiple organ dysfunction syndrome | 35.98 | 16.39 | 140 | 45124 | 151570 | 110392465 |
| Autoinflammatory disease | 35.98 | 16.39 | 11 | 45253 | 370 | 110543665 |
| Sensitivity to weather change | 35.79 | 16.39 | 31 | 45233 | 9997 | 110534038 |
| Hyperhidrosis | 35.63 | 16.39 | 16 | 45248 | 187282 | 110356753 |
| Rhabdomyolysis | 35.26 | 16.39 | 4 | 45260 | 120397 | 110423638 |
| Growth failure | 34.98 | 16.39 | 10 | 45254 | 265 | 110543770 |
| Hepatotoxicity | 34.93 | 16.39 | 79 | 45185 | 63321 | 110480714 |
| Adrenal suppression | 34.90 | 16.39 | 16 | 45248 | 1680 | 110542355 |
| Epidural lipomatosis | 34.86 | 16.39 | 17 | 45247 | 2050 | 110541985 |
| Atrial fibrillation | 34.63 | 16.39 | 26 | 45238 | 229616 | 110314419 |
| Memory impairment | 34.19 | 16.39 | 19 | 45245 | 196925 | 110347110 |
| Folliculitis | 34.03 | 16.39 | 13 | 45251 | 167640 | 110376395 |
| Blister | 33.96 | 16.39 | 26 | 45238 | 227350 | 110316685 |
| Balance disorder | 33.81 | 16.39 | 4 | 45260 | 116556 | 110427479 |
| Cytomegalovirus hepatitis | 33.61 | 16.39 | 13 | 45251 | 893 | 110543142 |
| Electrocardiogram QT prolonged | 33.52 | 16.39 | 3 | 45261 | 108957 | 110435078 |
| Renal mass | 33.46 | 16.39 | 20 | 45244 | 3615 | 110540420 |
| Inappropriate schedule of product administration | 33.44 | 16.39 | 21 | 45243 | 203616 | 110340419 |
| Bradycardia | 33.37 | 16.39 | 11 | 45253 | 155506 | 110388529 |
| Gastrooesophageal reflux disease | 33.27 | 16.39 | 16 | 45248 | 179960 | 110364075 |
| Amyloidosis | 33.24 | 16.39 | 19 | 45245 | 3162 | 110540873 |
| Purpura | 32.76 | 16.39 | 45 | 45219 | 24343 | 110519692 |
| Therapeutic response decreased | 32.43 | 16.39 | 100 | 45164 | 96399 | 110447636 |
| Pain | 31.82 | 16.39 | 558 | 44706 | 954397 | 109589638 |
| Hypertensive cardiomyopathy | 31.54 | 16.39 | 10 | 45254 | 380 | 110543655 |
| Erythema | 31.47 | 16.39 | 44 | 45220 | 291403 | 110252632 |
| Sepsis | 31.14 | 16.39 | 235 | 45029 | 327111 | 110216924 |
| Blood glucose increased | 30.94 | 16.39 | 8 | 45256 | 132488 | 110411547 |
| Helicobacter infection | 30.92 | 16.39 | 18 | 45246 | 181859 | 110362176 |
| Hypokalaemia | 30.77 | 16.39 | 152 | 45112 | 182296 | 110361739 |
| Deep vein thrombosis | 30.69 | 16.39 | 126 | 45138 | 139761 | 110404274 |
| Joint injury | 30.50 | 16.39 | 57 | 45207 | 39937 | 110504098 |
| Dry skin | 30.48 | 16.39 | 4 | 45260 | 107649 | 110436386 |
| Back disorder | 30.23 | 16.39 | 40 | 45224 | 20882 | 110523153 |
| Hepatosplenomegaly | 30.13 | 16.39 | 24 | 45240 | 6895 | 110537140 |
| Oral fungal infection | 29.74 | 16.39 | 20 | 45244 | 4432 | 110539603 |
| White blood cell count decreased | 29.71 | 16.39 | 30 | 45234 | 229360 | 110314675 |
| Inflammatory marker increased | 29.62 | 16.39 | 33 | 45231 | 14436 | 110529599 |
| Parvovirus infection | 29.53 | 16.39 | 12 | 45252 | 939 | 110543096 |
| Toothache | 29.43 | 16.39 | 42 | 45222 | 23533 | 110520502 |
| Haematochezia | 28.92 | 16.39 | 6 | 45258 | 115518 | 110428517 |
| Skin graft infection | 28.70 | 16.39 | 7 | 45257 | 98 | 110543937 |
| Mucosal inflammation | 28.64 | 16.39 | 3 | 45261 | 96138 | 110447897 |
| Fibromyalgia | 28.55 | 16.39 | 142 | 45122 | 170767 | 110373268 |
| Irritable bowel syndrome | 28.28 | 16.39 | 16 | 45248 | 164199 | 110379836 |
| Duodenal ulcer perforation | 28.26 | 16.39 | 19 | 45245 | 177681 | 110366354 |
| Laryngeal stenosis | 28.18 | 16.39 | 13 | 45251 | 1385 | 110542650 |
| Vision blurred | 27.91 | 16.39 | 9 | 45255 | 129013 | 110415022 |
| Dysphagia | 27.87 | 16.39 | 14 | 45250 | 153586 | 110390449 |
| Lethargy | 27.67 | 16.39 | 3 | 45261 | 93573 | 110450462 |
| Bronchitis | 27.47 | 16.39 | 15 | 45249 | 157017 | 110387018 |
| Renal failure | 27.06 | 16.39 | 172 | 45092 | 226402 | 110317633 |
| Product dose omission issue | 27.03 | 16.39 | 57 | 45207 | 321725 | 110222310 |
| Chills | 26.95 | 16.39 | 23 | 45241 | 190557 | 110353478 |
| Skin fissures | 26.83 | 16.39 | 41 | 45223 | 24417 | 110519618 |
| Muscle injury | 26.83 | 16.39 | 12 | 45252 | 140795 | 110403240 |
| Medical device site discomfort | 26.76 | 16.39 | 8 | 45256 | 249 | 110543786 |
| Anaemia | 26.75 | 16.39 | 124 | 45140 | 546962 | 109997073 |
| Myalgia | 26.67 | 16.39 | 31 | 45233 | 222350 | 110321685 |
| Product use in unapproved indication | 26.58 | 16.39 | 290 | 44974 | 447087 | 110096948 |
| Hypofibrinogenaemia | 26.26 | 16.39 | 15 | 45249 | 2492 | 110541543 |
| Agitation | 26.07 | 16.39 | 7 | 45257 | 113044 | 110430991 |
| Depressed level of consciousness | 25.80 | 16.39 | 7 | 45257 | 112271 | 110431764 |
| Testicular seminoma (pure) | 25.27 | 16.39 | 7 | 45257 | 165 | 110543870 |
| Borrelia infection | 25.20 | 16.39 | 8 | 45256 | 305 | 110543730 |
| Chronic obstructive pulmonary disease | 24.72 | 16.39 | 7 | 45257 | 109151 | 110434884 |
| Gastrointestinal haemorrhage | 24.62 | 16.39 | 19 | 45245 | 165499 | 110378536 |
| Suicide attempt | 24.61 | 16.39 | 6 | 45258 | 103388 | 110440647 |
| Injury | 24.33 | 16.39 | 22 | 45242 | 177243 | 110366792 |
| Tumour necrosis factor receptor-associated periodic syndrome | 24.27 | 16.39 | 6 | 45258 | 89 | 110543946 |
| Hyperplasia | 24.15 | 16.39 | 12 | 45252 | 1506 | 110542529 |
| Diaphragm muscle weakness | 24.09 | 16.39 | 7 | 45257 | 197 | 110543838 |
| Urinary tract infection | 24.03 | 16.39 | 62 | 45202 | 326220 | 110217815 |
| Acute kidney injury | 23.95 | 16.39 | 157 | 45107 | 635273 | 109908762 |
| Opportunistic infection | 23.87 | 16.39 | 16 | 45248 | 3527 | 110540508 |
| Central nervous system lymphoma | 23.57 | 16.39 | 15 | 45249 | 3029 | 110541006 |
| Muckle-Wells syndrome | 23.54 | 16.39 | 4 | 45260 | 6 | 110544029 |
| Fluid retention | 23.39 | 16.39 | 5 | 45259 | 94302 | 110449733 |
| Oxygen saturation decreased | 23.37 | 16.39 | 18 | 45246 | 156964 | 110387071 |
| Bronchopulmonary aspergillosis | 23.32 | 16.39 | 43 | 45221 | 29820 | 110514215 |
| Acne cystic | 23.25 | 16.39 | 10 | 45254 | 902 | 110543133 |
| Focal nodular hyperplasia | 23.24 | 16.39 | 10 | 45254 | 903 | 110543132 |
| Rectal haemorrhage | 23.16 | 16.39 | 10 | 45254 | 119823 | 110424212 |
| Incorrect dose administered | 22.82 | 16.39 | 7 | 45257 | 103634 | 110440401 |
| Rhinorrhoea | 22.49 | 16.39 | 7 | 45257 | 102659 | 110441376 |
| Splenic abscess | 22.37 | 16.39 | 10 | 45254 | 990 | 110543045 |
| Breast ulceration | 22.25 | 16.39 | 7 | 45257 | 259 | 110543776 |
| Epistaxis | 22.02 | 16.39 | 13 | 45251 | 130359 | 110413676 |
| Demyelination | 21.92 | 16.39 | 23 | 45241 | 9406 | 110534629 |
| Visual impairment | 21.88 | 16.39 | 14 | 45250 | 134414 | 110409621 |
| Wound | 21.88 | 16.39 | 39 | 45225 | 234398 | 110309637 |
| Sleep disorder due to general medical condition, insomnia type | 21.76 | 16.39 | 8 | 45256 | 105635 | 110438400 |
| Symptom recurrence | 21.74 | 16.39 | 17 | 45247 | 4755 | 110539280 |
| Impaired gastric emptying | 21.73 | 16.39 | 27 | 45237 | 13248 | 110530787 |
| Acute myocardial infarction | 21.71 | 16.39 | 4 | 45260 | 83773 | 110460262 |
| Lip dry | 21.61 | 16.39 | 7 | 45257 | 100076 | 110443959 |
| Pyrexia | 21.58 | 16.39 | 500 | 44764 | 897765 | 109646270 |
| Epstein-Barr viraemia | 21.36 | 16.39 | 15 | 45249 | 3564 | 110540471 |
| Cutaneous amyloidosis | 21.21 | 16.39 | 5 | 45259 | 60 | 110543975 |
| Tooth disorder | 21.20 | 16.39 | 41 | 45223 | 29468 | 110514567 |
| Skin exfoliation | 21.03 | 16.39 | 5 | 45259 | 87646 | 110456389 |
| Nasal congestion | 21.00 | 16.39 | 7 | 45257 | 98275 | 110445760 |
| Hodgkin's disease | 20.94 | 16.39 | 9 | 45255 | 811 | 110543224 |
| Varicella | 20.71 | 16.39 | 15 | 45249 | 3740 | 110540295 |
| Infusion related reaction | 20.69 | 16.39 | 83 | 45181 | 381079 | 110162956 |
| Spondyloarthropathy | 20.60 | 16.39 | 11 | 45253 | 1603 | 110542432 |
| Chronic infantile neurological cutaneous and articular syndrome | 20.41 | 16.39 | 3 | 45261 | 0 | 110544035 |
| Multiple-drug resistance | 20.20 | 16.39 | 26 | 45238 | 13209 | 110530826 |
| Mouth ulceration | 20.16 | 16.39 | 54 | 45210 | 48084 | 110495951 |
| Skin striae | 19.97 | 16.39 | 12 | 45252 | 2189 | 110541846 |
| Aspartate aminotransferase increased | 19.49 | 16.39 | 22 | 45242 | 159914 | 110384121 |
| Abdominal distension | 19.33 | 16.39 | 26 | 45238 | 175077 | 110368958 |
| Bacteraemia | 19.23 | 16.39 | 49 | 45215 | 42341 | 110501694 |
| Chest pain | 19.16 | 16.39 | 84 | 45180 | 376291 | 110167744 |
| Wrong technique in product usage process | 19.05 | 16.39 | 6 | 45258 | 87342 | 110456693 |
| Hyperlipidaemia | 19.00 | 16.39 | 44 | 45220 | 35804 | 110508231 |
| Mental status changes | 18.95 | 16.39 | 4 | 45260 | 76118 | 110467917 |
| Nasopharyngitis | 18.90 | 16.39 | 90 | 45174 | 394271 | 110149764 |
| Drug dependence | 18.86 | 16.39 | 54 | 45210 | 49966 | 110494069 |
| Embolism | 18.85 | 16.39 | 28 | 45236 | 16261 | 110527774 |
| Seizure | 18.72 | 16.39 | 39 | 45225 | 221146 | 110322889 |
| Prescribed underdose | 18.70 | 16.39 | 64 | 45200 | 65110 | 110478925 |
| Alanine aminotransferase increased | 18.60 | 16.39 | 29 | 45235 | 183744 | 110360291 |
| Bacterial tracheitis | 18.51 | 16.39 | 5 | 45259 | 107 | 110543928 |
| Chondrocalcinosis | 18.48 | 16.39 | 11 | 45253 | 1974 | 110542061 |
| Posterior reversible encephalopathy syndrome | 18.43 | 16.39 | 42 | 45222 | 33819 | 110510216 |
| Melaena | 18.43 | 16.39 | 3 | 45261 | 68754 | 110475281 |
| Bacterial sepsis | 18.35 | 16.39 | 22 | 45242 | 10404 | 110533631 |
| Solar urticaria | 18.29 | 16.39 | 5 | 45259 | 112 | 110543923 |
| Hospitalisation | 18.03 | 16.39 | 19 | 45245 | 142474 | 110401561 |
| Liver disorder | 17.96 | 16.39 | 19 | 45245 | 142224 | 110401811 |
| Viral infection | 17.79 | 16.39 | 55 | 45209 | 53084 | 110490951 |
| Haematuria | 17.58 | 16.39 | 6 | 45258 | 82999 | 110461036 |
| Seminoma | 17.58 | 16.39 | 6 | 45258 | 288 | 110543747 |
| Orthostatic hypotension | 17.52 | 16.39 | 3 | 45261 | 66246 | 110477789 |
| Periodontal inflammation | 17.45 | 16.39 | 4 | 45260 | 42 | 110543993 |
| Blood creatinine increased | 17.45 | 16.39 | 30 | 45234 | 182859 | 110361176 |
| Colitis ulcerative | 17.44 | 16.39 | 5 | 45259 | 77358 | 110466677 |
| Cystitis | 17.44 | 16.39 | 3 | 45261 | 66033 | 110478002 |
| International normalised ratio increased | 17.16 | 16.39 | 7 | 45257 | 86765 | 110457270 |
| Blood alkaline phosphatase increased | 17.11 | 16.39 | 4 | 45260 | 70931 | 110473104 |
| Soft tissue swelling | 17.09 | 16.39 | 10 | 45254 | 1739 | 110542296 |
| Chronic kidney disease | 17.07 | 16.39 | 5 | 45259 | 76286 | 110467749 |
| Spinal fracture | 16.94 | 16.39 | 32 | 45232 | 22601 | 110521434 |
| Joint range of motion decreased | 16.86 | 16.39 | 15 | 45249 | 121817 | 110422218 |
| Transient ischaemic attack | 16.69 | 16.39 | 3 | 45261 | 63979 | 110480056 |
| Hypertransaminasaemia | 16.57 | 16.39 | 33 | 45231 | 24222 | 110519813 |
| Hand deformity | 16.53 | 16.39 | 149 | 45115 | 218357 | 110325678 |
None
| Source | Code | Description |
|---|---|---|
| ATC | L04AC03 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Interleukin inhibitors |
| FDA MoA | N0000175709 | Interleukin 1 Receptor Antagonists |
| FDA EPC | N0000175710 | Interleukin-1 Receptor Antagonist |
| MeSH PA | D018501 | Antirheumatic Agents |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:35480 | analgesic |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
| CHEBI has role | CHEBI:35705 | immunosuppressive agent |
| CHEBI has role | CHEBI:35842 | antirheumatic drug |
| CHEBI has role | CHEBI:35845 | gout suppressant |
| CHEBI has role | CHEBI:50177 | dermatologic drug |
| CHEBI has role | CHEBI:63726 | neuroprotective agent |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:65023 | anti-asthmatic agent |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:76916 | hyperglycemic agent |
| CHEBI has role | CHEBI:149553 | anticoronaviral agent |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Familial Mediterranean fever | indication | 12579009 | DOID:2987 |
| Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
| Chronic infantile neurological, cutaneous and articular syndrome | indication | 239826001 | |
| Still's disease | indication | 239920006 | DOID:14256 |
| Cryopyrin associated periodic syndrome | indication | 430079001 | |
| COVID19 pneumonia requiring supplemental oxygen | indication | 882785000000000000 |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Interleukin-1 receptor, type I | Membrane receptor | ANTAGONIST | Kd | 7.82 | IUPHAR | DRUG LABEL |
| ID | Source |
|---|---|
| D02934 | KEGG_DRUG |
| 4021281 | VUID |
| N0000179382 | NUI |
| 4021281 | VANDF |
| CHEBI:231683 | CHEBI |
| CHEMBL1201570 | ChEMBL_ID |
| 6972 | IUPHAR_LIGAND_ID |
| DB00026 | DRUGBANK_ID |
| 352734 | RXNORM |
| 16200 | MMSL |
| 42416 | MMSL |
| d04775 | MMSL |
| 009431 | NDDF |
| 009432 | NDDF |
| 385549000 | SNOMEDCT_US |
| 395279009 | SNOMEDCT_US |
| C0245109 | UMLSCUI |
| D053590 | MESH_DESCRIPTOR_UI |
| 7137 | INN_ID |
| 9013DUQ28K | UNII |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Kineret | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66658-234 | INJECTION, SOLUTION | 100 mg | SUBCUTANEOUS | BLA | 33 sections |
| Kineret | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66658-234 | INJECTION, SOLUTION | 100 mg | SUBCUTANEOUS | BLA | 33 sections |