anakinra 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
interleukin receptor antagonists and interleukin antagonists	5017	143090-92-0

Description:

Molecule	Description
Synonyms: anakinra kineret	A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA. As IL-1 levels are elevated in patients with COVID-19, anakinra is currently being investigated for its potential to combat cytokine release syndrome (CRS) in patients with severely ill COVID-19. Molecular weight: 17257.66 Formula: C759H1186N208O232S10 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 7115.02 ALOGS: ROTB: None

Molecule

Description

Synonyms:

anakinra
kineret

A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA. As IL-1 levels are elevated in patients with COVID-19, anakinra is currently being investigated for its potential to combat cytokine release syndrome (CRS) in patients with severely ill COVID-19.

Molecular weight: 17257.66
Formula: C759H1186N208O232S10
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 7115.02
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.10	g	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
March 8, 2002	EMA
Nov. 14, 2001	FDA	BIOVITRUM AB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	726.33	22.16	1548	28660	1043217	62415597
Red blood cell sedimentation rate abnormal	515.32	22.16	230	29978	19552	63439262
Haemophagocytic lymphohistiocytosis	408.59	22.16	163	30045	10464	63448350
Mobility decreased	371.56	22.16	367	29841	120792	63338022
Bone density decreased	345.98	22.16	159	30049	14453	63444361
Polyarthritis	339.93	22.16	141	30067	10005	63448809
Body height below normal	335.20	22.16	95	30113	2088	63456726
Human antichimeric antibody positive	306.25	22.16	84	30124	1630	63457184
Deformity	304.66	22.16	136	30072	11548	63447266
Off label use	303.59	22.16	850	29358	673612	62785202
Synovitis	302.63	22.16	407	29801	186511	63272303
Oral mucosal exfoliation	299.89	22.16	82	30126	1572	63457242
Adrenal insufficiency	280.43	22.16	147	30061	17768	63441046
Ill-defined disorder	275.55	22.16	261	29947	81494	63377320
Loss of consciousness	273.21	22.16	308	29900	117813	63341001
Drug intolerance	254.12	22.16	494	29714	308167	63150647
Musculoskeletal disorder	252.78	22.16	144	30064	20500	63438314
Joint destruction	251.12	22.16	99	30109	6153	63452661
Wheelchair user	243.12	22.16	97	30111	6222	63452592
Herpes zoster	230.93	22.16	238	29970	82224	63376590
Soft tissue disorder	224.24	22.16	83	30125	4339	63454475
Cutaneous vasculitis	220.66	22.16	86	30122	5183	63453631
Contraindicated product administered	220.16	22.16	381	29827	217267	63241547
Therapeutic product effect decreased	216.40	22.16	354	29854	192833	63265981
Obesity	215.27	22.16	149	30059	29803	63429011
Joint swelling	209.55	22.16	473	29735	327193	63131621
Arthropathy	195.66	22.16	378	29830	234414	63224400
Liver function test abnormal	193.89	22.16	170	30038	48011	63410803
Rheumatoid factor positive	188.07	22.16	216	29992	84190	63374624
Arthritis	183.61	22.16	250	29958	115671	63343143
Therapeutic product effect incomplete	182.11	22.16	259	29949	124797	63334017
Red blood cell sedimentation rate increased	178.61	22.16	156	30052	43826	63414988
Ankle arthroplasty	178.61	22.16	56	30152	1757	63457057
Fine motor skill dysfunction	175.02	22.16	71	30137	4754	63454060
Septic shock	169.90	22.16	183	30025	66446	63392368
Rheumatoid arthritis	158.24	22.16	363	29845	253456	63205358
Drug specific antibody	156.43	22.16	54	30154	2301	63456513
Treatment failure	150.70	22.16	308	29900	198735	63260079
Antibody test positive	149.07	22.16	54	30154	2653	63456161
Pneumonia viral	141.29	22.16	71	30137	7851	63450963
Secretion discharge	140.85	22.16	82	30126	12149	63446665
Nodule	138.06	22.16	99	30109	20927	63437887
Hepatosplenic T-cell lymphoma	133.45	22.16	35	30173	568	63458246
Therapy non-responder	131.32	22.16	171	30037	75730	63383084
Body tinea	128.22	22.16	44	30164	1841	63456973
Ankle operation	123.64	22.16	39	30169	1248	63457566
C-reactive protein abnormal	121.69	22.16	129	30079	45967	63412847
Gastroenteritis viral	120.99	22.16	96	30112	23604	63435210
Immunodeficiency	120.82	22.16	90	30118	20164	63438650
Loss of personal independence in daily activities	117.91	22.16	185	30023	97105	63361709
Impaired quality of life	116.84	22.16	76	30132	13707	63445107
Fall	115.96	22.16	23	30185	392311	63066503
Vasculitic rash	112.74	22.16	37	30171	1347	63457467
Infection	112.25	22.16	299	29909	228874	63229940
Condition aggravated	112.07	22.16	432	29776	401785	63057029
Adenovirus infection	110.78	22.16	47	30161	3524	63455290
Inhibitory drug interaction	107.04	22.16	43	30165	2806	63456008
Arthralgia	103.06	22.16	538	29670	569172	62889642
Spinal stenosis	101.95	22.16	72	30136	14853	63443961
Drug hypersensitivity	101.92	22.16	352	29856	310335	63148479
Infection susceptibility increased	101.51	22.16	44	30164	3477	63455337
Growth failure	101.26	22.16	25	30183	314	63458500
Hepatitis	100.88	22.16	109	30099	39679	63419135
Smear cervix abnormal	98.84	22.16	41	30167	2905	63455909
Psoriasis	96.66	22.16	159	30049	86798	63372016
Foot operation	89.99	22.16	51	30157	7180	63451634
C-reactive protein increased	88.02	22.16	160	30048	94547	63364267
Arthrodesis	87.33	22.16	37	30171	2764	63456050
Asthenia	83.67	22.16	39	30169	383565	63075249
Quality of life decreased	83.21	22.16	52	30156	8751	63450063
Infiltration anaesthesia	82.02	22.16	19	30189	178	63458636
Hypocalcaemia	80.59	22.16	87	30121	31626	63427188
Foot deformity	78.96	22.16	81	30127	27772	63431042
Confusional state	78.44	22.16	10	30198	236370	63222444
Glucose tolerance impaired	78.12	22.16	45	30163	6532	63452282
Juvenile idiopathic arthritis	78.08	22.16	36	30172	3290	63455524
Headache	75.15	22.16	116	30092	633125	62825689
Dyspnoea	74.86	22.16	125	30083	661188	62797626
Sensitivity to weather change	69.03	22.16	43	30165	7194	63451620
Leukopenia	68.56	22.16	128	30080	77162	63381652
Fibromyalgia	67.40	22.16	130	30078	80290	63378524
Short stature	66.66	22.16	21	30187	669	63458145
Hepatotoxicity	66.44	22.16	85	30123	36956	63421858
Complications of bone marrow transplant	65.59	22.16	19	30189	452	63458362
Death	64.88	22.16	50	30158	374331	63084483
Constipation	64.70	22.16	14	30194	224929	63233885
Pulmonary fibrosis	64.66	22.16	87	30121	39722	63419092
Injection site reaction	63.64	22.16	106	30102	58418	63400396
Shoulder arthroplasty	63.05	22.16	33	30175	3969	63454845
Clubbing	62.15	22.16	18	30190	428	63458386
Wound	61.91	22.16	4	30204	163259	63295555
Weight decreased	60.53	22.16	28	30180	276770	63182044
Decreased appetite	60.39	22.16	22	30186	251030	63207784
Purpura	57.84	22.16	46	30162	11339	63447475
Sinusitis	57.75	22.16	18	30190	226635	63232179
Serum ferritin increased	57.13	22.16	36	30172	6146	63452668
Viraemia	56.94	22.16	22	30186	1294	63457520
Bone density increased	56.69	22.16	19	30189	739	63458075
Fatigue	56.39	22.16	225	29983	887803	62571011
Drug ineffective for unapproved indication	56.17	22.16	75	30133	33988	63424826
Anti-neutrophil cytoplasmic antibody positive vasculitis	54.69	22.16	27	30181	2872	63455942
Anxiety	54.14	22.16	18	30190	217523	63241291
Skin disorder	53.37	22.16	68	30140	29439	63429375
Limb discomfort	52.99	22.16	68	30140	29648	63429166
Pneumonia	52.83	22.16	85	30123	456682	63002132
Hypoaesthesia	51.53	22.16	9	30199	168384	63290430
Dehydration	51.47	22.16	10	30198	173344	63285470
Poor quality sleep	51.19	22.16	55	30153	19880	63438934
Muscle spasms	50.84	22.16	7	30201	156143	63302671
Musculoskeletal pain	49.80	22.16	125	30083	92152	63366662
Somnolence	49.61	22.16	12	30196	178673	63280141
Discomfort	48.97	22.16	10	30198	167364	63291450
Serum amyloid A protein increased	48.78	22.16	14	30194	322	63458492
Clear cell renal cell carcinoma	47.57	22.16	20	30188	1465	63457349
Skin fissures	47.41	22.16	41	30167	11347	63447467
Paraesthesia	46.71	22.16	9	30199	156957	63301857
Back disorder	46.55	22.16	40	30168	10977	63447837
General physical health deterioration	46.18	22.16	19	30189	201383	63257431
Abdominal discomfort	45.93	22.16	51	30157	320834	63137980
Human anti-human antibody test	45.05	22.16	14	30194	426	63458388
Febrile neutropenia	44.61	22.16	3	30205	118446	63340368
Joint arthroplasty	44.32	22.16	23	30185	2718	63456096
Epstein-Barr viraemia	44.11	22.16	17	30191	993	63457821
Joint effusion	43.68	22.16	47	30161	17013	63441801
Asthma	43.26	22.16	5	30203	127556	63331258
Toxicity to various agents	42.81	22.16	33	30175	247217	63211597
Oral herpes	42.36	22.16	57	30151	26017	63432797
Interstitial lung disease	42.30	22.16	92	30116	61816	63396998
Varicella zoster virus infection	41.87	22.16	22	30186	2667	63456147
Pain in extremity	41.86	22.16	58	30150	331428	63127386
Drug tolerance	41.70	22.16	31	30177	6918	63451896
Oedema peripheral	41.67	22.16	19	30189	189492	63269322
Hyponatraemia	41.66	22.16	3	30205	111897	63346917
Cough	41.37	22.16	47	30161	292696	63166118
Hair follicle tumour benign	41.15	22.16	13	30195	418	63458396
Pleural effusion	40.94	22.16	117	30091	93093	63365721
Tremor	40.60	22.16	7	30201	132232	63326582
Hepatosplenomegaly	39.61	22.16	21	30187	2593	63456221
Impaired work ability	39.33	22.16	45	30163	17430	63441384
Drug interaction	39.14	22.16	31	30177	229100	63229714
Renal mass	38.78	22.16	20	30188	2333	63456481
Lower respiratory tract infection	38.50	22.16	8	30200	132299	63326515
Exposure during pregnancy	38.46	22.16	13	30195	155534	63303280
Adrenal suppression	38.39	22.16	15	30193	909	63457905
Endodontic procedure	38.24	22.16	22	30186	3185	63455629
Therapeutic response decreased	38.19	22.16	88	30120	61437	63397377
Osteomyelitis	37.94	22.16	54	30154	25966	63432848
Overdose	37.83	22.16	5	30203	115073	63343741
Neuropathy peripheral	37.22	22.16	5	30203	113662	63345152
Palpitations	36.83	22.16	5	30203	112765	63346049
Neck pain	36.45	22.16	93	30115	69225	63389589
Haemoglobin decreased	36.25	22.16	12	30196	145473	63313341
Chest discomfort	35.62	22.16	5	30203	109964	63348850
Drug reaction with eosinophilia and systemic symptoms	35.07	22.16	60	30148	33776	63425038
Scar excision	34.92	22.16	8	30200	71	63458743
Alveolar proteinosis	34.81	22.16	11	30197	354	63458460
Cerebrovascular accident	34.78	22.16	5	30203	108019	63350795
Muscular weakness	34.38	22.16	8	30200	122345	63336469
Alopecia	34.30	22.16	68	30140	337468	63121346
Platelet count decreased	33.83	22.16	7	30201	116115	63342699
Myocardial infarction	33.66	22.16	4	30204	99889	63358925
Hyperlipidaemia	33.66	22.16	44	30164	19527	63439287
Demyelination	33.12	22.16	27	30181	6893	63451921
Graft versus host disease in gastrointestinal tract	32.80	22.16	20	30188	3221	63455593
Hepatic enzyme increased	31.36	22.16	30	30178	202298	63256516
Immune effector cell-associated neurotoxicity syndrome	30.89	22.16	17	30191	2260	63456554
Pneumonia lipoid	30.60	22.16	8	30200	128	63458686
Diaphragm muscle weakness	30.26	22.16	6	30202	24	63458790
Liver function test increased	29.90	22.16	55	30153	32756	63426058
Autoinflammatory disease	29.81	22.16	9	30199	248	63458566
Toothache	29.71	22.16	41	30167	19158	63439656
Laryngeal stenosis	29.54	22.16	13	30195	1065	63457749
Encephalitis viral	29.35	22.16	15	30193	1717	63457097
Human herpesvirus 6 infection	29.29	22.16	18	30190	2939	63455875
Steroid dependence	29.09	22.16	15	30193	1749	63457065
White blood cell count decreased	28.96	22.16	15	30193	139089	63319725
Atrial fibrillation	28.39	22.16	10	30198	116626	63342188
Feeling abnormal	28.05	22.16	18	30190	148374	63310440
Systemic lupus erythematosus	27.94	22.16	35	30173	208883	63249931
Pericarditis	27.68	22.16	14	30194	131565	63327249
Diffuse large B-cell lymphoma	27.61	22.16	24	30184	6688	63452126
Pemphigus	27.60	22.16	28	30180	183698	63275116
Gait disturbance	27.42	22.16	28	30180	183150	63275664
Prescribed underdose	27.35	22.16	50	30158	29639	63429175
Chills	27.12	22.16	10	30198	113368	63345446
Graft versus host disease in skin	27.05	22.16	17	30191	2888	63455926
Post transplant lymphoproliferative disorder	27.00	22.16	21	30187	5010	63453804
Bronchitis	26.72	22.16	13	30195	124922	63333892
Deep vein thrombosis	26.70	22.16	4	30204	83796	63375018
Dry mouth	26.53	22.16	3	30205	77860	63380954
Oxygen saturation decreased	26.51	22.16	5	30203	88580	63370234
Dyspepsia	26.22	22.16	8	30200	102188	63356626
Irritable bowel syndrome	26.10	22.16	4	30204	82408	63376406
Myalgia	26.06	22.16	19	30189	146510	63312304
Cytokine release syndrome	25.90	22.16	33	30175	14281	63444533
Pruritus	25.81	22.16	87	30121	361366	63097448
Borrelia infection	25.45	22.16	8	30200	253	63458561
Gastrooesophageal reflux disease	25.43	22.16	7	30201	95632	63363182
Ankylosing spondylitis	25.32	22.16	28	30180	10446	63448368
Glossodynia	24.94	22.16	29	30179	178847	63279967
Exfoliative rash	24.86	22.16	16	30192	2831	63455983
Balance disorder	24.77	22.16	5	30203	84417	63374397
Soft tissue swelling	24.71	22.16	12	30196	1232	63457582
Medical device site discomfort	24.62	22.16	8	30200	282	63458532
Embolism	24.25	22.16	24	30184	7882	63450932
Drug abuse	24.19	22.16	3	30205	72515	63386299
Impaired gastric emptying	23.92	22.16	27	30181	10305	63448509
Tumour necrosis factor receptor-associated periodic syndrome	23.70	22.16	6	30202	84	63458730
Mouth ulceration	23.65	22.16	50	30158	32934	63425880
Infusion related reaction	23.62	22.16	51	30157	245470	63213344
Hyperferritinaemia	22.91	22.16	7	30201	201	63458613
Finger deformity	22.81	22.16	23	30185	7722	63451092
Maternal exposure during pregnancy	22.62	22.16	44	30164	220018	63238796
Fasciitis	22.61	22.16	9	30199	573	63458241
Bradycardia	22.20	22.16	4	30204	73223	63385591

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Apparent death	990.06	32.31	227	10156	3417	34943131
Diverticulitis	663.73	32.31	242	10141	19762	34926786
Off label use	624.37	32.31	686	9697	418838	34527710
Joint swelling	436.47	32.31	252	10131	59638	34886910
Deep vein thrombosis	411.27	32.31	250	10133	64998	34881550
Pulmonary thrombosis	378.86	32.31	124	10259	7283	34939265
Drug ineffective	377.05	32.31	559	9824	456192	34490356
Red blood cell sedimentation rate increased	349.18	32.31	123	10260	9039	34937509
Pulmonary embolism	329.68	32.31	246	10137	89500	34857048
Terminal state	293.84	32.31	88	10295	3846	34942702
Renal failure	277.82	32.31	261	10122	130296	34816252
C-reactive protein abnormal	243.12	32.31	93	10290	8617	34937931
Contraindicated product administered	195.93	32.31	105	10278	21376	34925172
Pain	193.97	32.31	269	10114	204406	34742142
Drug specific antibody present	192.41	32.31	61	10322	3224	34943324
Acne cystic	177.40	32.31	39	10344	475	34946073
Thrombosis	168.65	32.31	131	10252	50327	34896221
Photosensitivity reaction	156.76	32.31	72	10311	10522	34936026
Intestinal sepsis	151.33	32.31	36	10347	635	34945913
Joint arthroplasty	151.08	32.31	38	10345	853	34945695
Haemophagocytic lymphohistiocytosis	145.82	32.31	73	10310	12900	34933648
Drug use disorder	139.72	32.31	51	10332	4140	34942408
Sepsis	134.21	32.31	203	10180	166358	34780190
C-reactive protein increased	131.84	32.31	117	10266	53981	34892567
Drug intolerance	120.29	32.31	116	10267	59454	34887094
Intentional product use issue	97.90	32.31	104	10279	59712	34886836
Herpes zoster	97.16	32.31	81	10302	34318	34912230
Gait inability	92.08	32.31	64	10319	20694	34925854
Arthropathy	90.08	32.31	70	10313	26837	34919711
Stent placement	82.97	32.31	37	10346	5041	34941507
Drug reaction with eosinophilia and systemic symptoms	79.55	32.31	71	10312	32941	34913607
Urticaria	79.10	32.31	95	10288	62282	34884266
Drug ineffective for unapproved indication	77.87	32.31	61	10322	23654	34922894
Treatment failure	74.27	32.31	80	10303	46617	34899931
Knee arthroplasty	72.35	32.31	38	10345	7406	34939142
Interstitial lung disease	70.89	32.31	92	10291	65190	34881358
Stomatitis	69.66	32.31	74	10309	42440	34904108
Meningitis viral	66.43	32.31	20	10363	887	34945661
Propionibacterium infection	63.78	32.31	15	10368	251	34946297
Dyspnoea	63.31	32.31	17	10366	376765	34569783
Drug hypersensitivity	61.58	32.31	96	10287	80433	34866115
Diarrhoea	59.39	32.31	21	10362	389891	34556657
Drug dependence	54.23	32.31	50	10333	24167	34922381
Feeling abnormal	47.78	32.31	75	10308	63160	34883388
Central nervous system lymphoma	47.66	32.31	16	10367	1012	34945536
Post transplant lymphoproliferative disorder	46.08	32.31	27	10356	6501	34940047
Therapeutic product effect decreased	45.78	32.31	54	10329	34689	34911859
Drug interaction	44.46	32.31	7	10376	225939	34720609
Cytomegalovirus hepatitis	41.77	32.31	12	10371	451	34946097
Injection site reaction	41.63	32.31	33	10350	13000	34933548
Myocardial infarction	40.50	32.31	102	10281	120983	34825565
Rheumatoid arthritis	38.55	32.31	52	10331	38186	34908362
Product use in unapproved indication	37.24	32.31	97	10286	117402	34829146
Immobilisation syndrome	36.66	32.31	10	10373	310	34946238
Varicella	36.58	32.31	15	10368	1662	34944886
Fatigue	34.12	32.31	36	10347	370617	34575931
Diffuse large B-cell lymphoma	33.31	32.31	23	10360	7347	34939201

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	799.02	22.52	1483	30296	1079430	78633179
Off label use	643.42	22.52	1225	30554	905990	78806619
Red blood cell sedimentation rate abnormal	498.84	22.52	217	31562	20746	79691863
Drug intolerance	454.56	22.52	542	31237	263577	79449032
Red blood cell sedimentation rate increased	396.67	22.52	240	31539	45702	79666907
Contraindicated product administered	370.38	22.52	381	31398	157157	79555452
Haemophagocytic lymphohistiocytosis	338.45	22.52	168	31611	21669	79690940
Apparent death	335.18	22.52	97	31682	2768	79709841
Joint swelling	328.65	22.52	484	31295	288162	79424447
Synovitis	326.48	22.52	349	31430	150385	79562224
Polyarthritis	325.50	22.52	137	31642	12065	79700544
Oral mucosal exfoliation	318.14	22.52	81	31698	1404	79711205
Human antichimeric antibody positive	310.11	22.52	81	31698	1560	79711049
C-reactive protein abnormal	309.00	22.52	209	31570	48158	79664451
Body height below normal	305.98	22.52	84	31695	1969	79710640
Arthropathy	288.69	22.52	354	31425	176757	79535852
Bone density decreased	284.69	22.52	128	31651	13219	79699390
Therapeutic product effect decreased	277.57	22.52	334	31445	163529	79549080
Treatment failure	270.17	22.52	336	31443	170150	79542459
Rheumatoid factor positive	262.56	22.52	206	31573	59633	79652976
Joint destruction	262.20	22.52	96	31683	5829	79706780
Rheumatoid arthritis	258.09	22.52	364	31415	208106	79504503
Herpes zoster	229.18	22.52	231	31548	92852	79619757
Pulmonary thrombosis	229.05	22.52	107	31672	12064	79700545
Wheelchair user	219.23	22.52	85	31694	6047	79706562
Terminal state	215.54	22.52	79	31700	4810	79707799
Adrenal insufficiency	210.83	22.52	135	31644	28352	79684257
Cutaneous vasculitis	191.58	22.52	84	31695	8168	79704441
Obesity	187.46	22.52	136	31643	34989	79677620
C-reactive protein increased	175.58	22.52	236	31543	128791	79583818
Mobility decreased	171.66	22.52	227	31552	121948	79590661
Fine motor skill dysfunction	166.10	22.52	67	31712	5290	79707319
Drug hypersensitivity	166.05	22.52	367	31412	298549	79414060
Drug specific antibody	163.96	22.52	55	31724	2573	79710036
Drug specific antibody present	161.87	22.52	70	31709	6582	79706027
Deformity	158.03	22.52	77	31702	9528	79703081
Musculoskeletal disorder	154.64	22.52	100	31679	21348	79691261
Joint arthroplasty	150.03	22.52	52	31727	2688	79709921
Arthritis	142.53	22.52	201	31578	114679	79597930
Nodule	138.80	22.52	96	31683	22898	79689711
Ill-defined disorder	136.18	22.52	149	31630	65726	79646883
Secretion discharge	136.08	22.52	81	31698	14941	79697668
Body tinea	132.51	22.52	43	31736	1811	79710798
Septic shock	132.27	22.52	201	31578	122600	79590009
Soft tissue disorder	130.19	22.52	50	31729	3465	79709144
Immunodeficiency	126.99	22.52	89	31690	21679	79690930
Fall	124.87	22.52	22	31757	487607	79225002
Antibody test positive	122.64	22.52	45	31734	2747	79709862
Dyspnoea	119.63	22.52	100	31679	856925	78855684
Gastroenteritis viral	118.69	22.52	90	31689	24741	79687868
Therapy non-responder	115.20	22.52	162	31617	92143	79620466
Therapeutic product effect incomplete	114.89	22.52	204	31575	141441	79571168
Condition aggravated	113.02	22.52	446	31333	500678	79211931
Ankle arthroplasty	111.56	22.52	36	31743	1489	79711120
Ankle operation	110.32	22.52	33	31746	1058	79711551
Smear cervix abnormal	108.17	22.52	40	31739	2496	79710113
Pneumonia viral	106.12	22.52	58	31721	9100	79703509
Impaired quality of life	105.98	22.52	68	31711	14318	79698291
Spinal stenosis	104.99	22.52	70	31709	15721	79696888
Drug ineffective for unapproved indication	104.33	22.52	115	31664	51123	79661486
Diverticulitis	103.91	22.52	109	31670	45827	79666782
Infection susceptibility increased	103.30	22.52	43	31736	3678	79708931
Intestinal sepsis	103.20	22.52	30	31749	869	79711740
Vasculitic rash	98.90	22.52	36	31743	2148	79710461
Confusional state	96.85	22.52	8	31771	317989	79394620
Inhibitory drug interaction	92.69	22.52	42	31737	4411	79708198
Hepatosplenic T-cell lymphoma	90.70	22.52	27	31752	851	79711758
Toxicity to various agents	90.13	22.52	28	31751	421512	79291097
Psoriasis	89.93	22.52	142	31637	89445	79623164
Liver function test abnormal	83.17	22.52	115	31664	64360	79648249
Foot deformity	80.76	22.52	71	31708	24003	79688606
Loss of personal independence in daily activities	78.37	22.52	144	31635	102436	79610173
Infiltration anaesthesia	76.61	22.52	17	31762	157	79712452
Interstitial lung disease	76.07	22.52	150	31629	112450	79600159
Loss of consciousness	74.37	22.52	189	31590	167754	79544855
Glucose tolerance impaired	74.28	22.52	44	31735	8040	79704569
Drug use disorder	74.08	22.52	45	31734	8606	79704003
Anxiety	73.62	22.52	7	31772	248505	79464104
Infection	73.02	22.52	237	31542	241475	79471134
Hepatitis	72.78	22.52	100	31679	55627	79656982
Juvenile idiopathic arthritis	71.85	22.52	36	31743	4727	79707882
Drug interaction	71.81	22.52	38	31741	415145	79297464
Short stature	69.53	22.52	21	31758	696	79711913
Post transplant lymphoproliferative disorder	69.50	22.52	48	31731	11416	79701193
Photosensitivity reaction	68.26	22.52	61	31718	21066	79691543
Decreased appetite	67.54	22.52	26	31753	342392	79370217
Constipation	65.70	22.52	16	31763	283034	79429575
Foot operation	65.57	22.52	36	31743	5697	79706912
Diffuse large B-cell lymphoma	64.70	22.52	47	31732	12102	79700507
Intentional product use issue	64.05	22.52	168	31611	151944	79560665
Complications of bone marrow transplant	62.99	22.52	19	31760	627	79711982
Pulmonary fibrosis	61.93	22.52	82	31697	44030	79668579
Injection site reaction	60.81	22.52	91	31688	54694	79657915
Arthrodesis	60.76	22.52	26	31753	2381	79710228
Hypocalcaemia	59.86	22.52	86	31693	49838	79662771
Pneumonia	59.33	22.52	108	31671	660138	79052471
Bone density increased	58.32	22.52	19	31760	810	79711799
General physical health deterioration	57.51	22.52	19	31760	275219	79437390
Somnolence	56.46	22.52	13	31766	238968	79473641
Propionibacterium infection	56.32	22.52	15	31764	312	79712297
Joint effusion	56.21	22.52	51	31728	17963	79694646
Dehydration	55.73	22.52	15	31764	248172	79464437
Skin disorder	55.38	22.52	68	31711	33875	79678734
Oedema peripheral	55.25	22.52	16	31763	252272	79460337
Fibromyalgia	55.14	22.52	95	31684	64245	79648364
Immune effector cell-associated neurotoxicity syndrome	54.17	22.52	32	31747	5816	79706793
Thrombosis	53.16	22.52	109	31670	83991	79628618
Arthralgia	52.85	22.52	399	31380	571404	79141205
Fatigue	52.80	22.52	192	31587	929535	78783074
Anti-neutrophil cytoplasmic antibody positive vasculitis	52.79	22.52	27	31752	3702	79708907
Quality of life decreased	52.53	22.52	39	31740	10381	79702228
Overdose	52.45	22.52	6	31773	184200	79528409
Drug reaction with eosinophilia and systemic symptoms	50.08	22.52	91	31688	64153	79648456
Knee arthroplasty	49.66	22.52	73	31706	43175	79669434
Platelet count decreased	49.26	22.52	9	31770	194655	79517954
Hypoaesthesia	48.28	22.52	7	31772	179345	79533264
Human anti-human antibody test	48.04	22.52	14	31765	409	79712200
Poor quality sleep	47.98	22.52	52	31727	22670	79689939
Death	47.94	22.52	96	31683	566418	79146191
Tremor	47.29	22.52	6	31773	170077	79542532
Paraesthesia	47.19	22.52	7	31772	176316	79536293
Skin fissures	46.76	22.52	40	31739	13033	79699576
Back disorder	46.76	22.52	38	31741	11540	79701069
Asthenia	45.64	22.52	84	31695	511605	79201004
Meningitis viral	45.37	22.52	20	31759	1968	79710641
Endodontic procedure	45.14	22.52	22	31757	2721	79709888
Neuropathy peripheral	44.56	22.52	3	31776	141302	79571307
Limb discomfort	44.47	22.52	60	31719	32790	79679819
Muscle spasms	44.38	22.52	8	31771	174722	79537887
Cerebrovascular accident	44.36	22.52	5	31774	155287	79557322
Stent placement	43.57	22.52	29	31750	6491	79706118
Oral herpes	43.18	22.52	54	31725	27400	79685209
Cough	42.68	22.52	50	31729	366739	79345870
Malignant neoplasm progression	42.55	22.52	3	31776	135987	79576622
Hair follicle tumour benign	42.31	22.52	13	31766	457	79712152
Pain	42.25	22.52	447	31332	703355	79009254
Transplant failure	41.96	22.52	25	31754	4616	79707993
Therapeutic response decreased	41.48	22.52	86	31693	66767	79645842
Shoulder arthroplasty	41.41	22.52	22	31757	3260	79709349
Serum ferritin increased	41.21	22.52	33	31746	9814	79702795
Weight decreased	40.71	22.52	49	31730	355149	79357460
Chest discomfort	40.57	22.52	4	31775	138040	79574569
Drug tolerance	40.47	22.52	31	31748	8644	79703965
Clear cell renal cell carcinoma	40.42	22.52	20	31759	2556	79710053
Sensitivity to weather change	40.30	22.52	30	31749	8017	79704592
Cytopenia	40.18	22.52	45	31734	20338	79692271
Purpura	40.03	22.52	44	31735	19483	79693126
Asthma	39.48	22.52	4	31775	135091	79577518
Atrial fibrillation	39.03	22.52	15	31764	197871	79514738
Palpitations	39.02	22.52	3	31776	126607	79586002
Impaired work ability	38.03	22.52	43	31736	19638	79692971
Sepsis	37.07	22.52	208	31571	269220	79443389
Serum amyloid A protein increased	36.70	22.52	11	31768	355	79712254
Scar excision	36.54	22.52	8	31771	69	79712540
Growth failure	35.96	22.52	10	31769	246	79712363
Renal mass	35.53	22.52	20	31759	3320	79709289
Wheezing	35.30	22.52	3	31776	116661	79595948
Wound	35.12	22.52	3	31776	116176	79596433
Adrenal suppression	34.95	22.52	15	31764	1384	79711225
Bradycardia	34.87	22.52	6	31773	135551	79577058
Hyperkalaemia	34.45	22.52	3	31776	114395	79598214
Toothache	34.19	22.52	41	31738	19929	79692680
Autoinflammatory disease	33.63	22.52	10	31769	314	79712295
Cytokine release syndrome	33.29	22.52	55	31724	35943	79676666
Oxygen saturation decreased	32.57	22.52	6	31773	129041	79583568
Product use in unapproved indication	32.29	22.52	190	31589	250169	79462440
Sinusitis	32.15	22.52	19	31760	195482	79517127
Cytomegalovirus hepatitis	32.09	22.52	12	31767	772	79711837
Laryngeal stenosis	31.64	22.52	13	31766	1075	79711534
Pain in extremity	31.45	22.52	61	31718	364477	79348132
Blister	31.37	22.52	5	31774	119471	79593138
Rhabdomyolysis	30.27	22.52	3	31776	103128	79609481
Pruritus	29.92	22.52	71	31708	394577	79318032
Febrile neutropenia	29.62	22.52	29	31750	230970	79481639
Clubbing	29.47	22.52	11	31768	704	79711905
Deep vein thrombosis	29.04	22.52	110	31669	120809	79591800
Headache	29.04	22.52	148	31631	653624	79058985
Hepatosplenomegaly	29.00	22.52	22	31757	6047	79706562
Chills	28.65	22.52	14	31765	160220	79552389
Lower respiratory tract infection	28.63	22.52	8	31771	129212	79583397
Hyperlipidaemia	28.46	22.52	43	31736	26050	79686559
Dysphagia	28.13	22.52	7	31772	122129	79590480
Medical device site discomfort	27.95	22.52	8	31771	219	79712390
Central nervous system lymphoma	27.92	22.52	15	31764	2274	79710335
Depressed level of consciousness	27.88	22.52	3	31776	96649	79615960
Pleural effusion	27.66	22.52	123	31656	145139	79567470
Discomfort	27.42	22.52	8	31771	125609	79587000
Finger deformity	27.00	22.52	23	31756	7451	79705158
Borrelia infection	26.97	22.52	8	31771	249	79712360
Product use issue	26.89	22.52	159	31620	209663	79502946
Agitation	26.57	22.52	4	31775	99711	79612898
Erythema	26.42	22.52	30	31749	223260	79489349
Balance disorder	26.27	22.52	4	31775	98853	79613756
Visual impairment	26.22	22.52	3	31776	92128	79620481
Hand deformity	26.17	22.52	96	31683	103823	79608786
White blood cell count decreased	26.09	22.52	22	31757	188266	79524343
Steroid dependence	25.97	22.52	15	31764	2615	79709994
Acute kidney injury	25.73	22.52	113	31666	519291	79193318
Mouth ulceration	25.72	22.52	51	31728	38343	79674266
Blood glucose increased	25.69	22.52	7	31772	114968	79597641
Bronchitis	25.59	22.52	10	31769	130634	79581975
Demyelination	25.59	22.52	23	31756	8000	79704609
Electrocardiogram QT prolonged	25.58	22.52	3	31776	90383	79622226
Hyperferritinaemia	25.55	22.52	10	31769	729	79711880
Alveolar proteinosis	24.91	22.52	10	31769	779	79711830
Gastrointestinal haemorrhage	24.79	22.52	14	31765	147705	79564904
Tumour necrosis factor receptor-associated periodic syndrome	24.76	22.52	6	31773	84	79712525
Prescribed underdose	24.52	22.52	43	31736	29471	79683138
Varicella	24.46	22.52	15	31764	2917	79709692
Tooth disorder	24.14	22.52	40	31739	26193	79686416
Joint injury	23.92	22.52	44	31735	31291	79681318
Dyspepsia	23.58	22.52	7	31772	108680	79603929
Product dose omission issue	23.51	22.52	39	31740	247498	79465111
Hyperhidrosis	23.16	22.52	16	31763	151476	79561133
Myalgia	23.00	22.52	24	31755	185617	79526992
Exposure during pregnancy	22.89	22.52	6	31773	101126	79611483
Urinary tract infection	22.75	22.52	47	31732	274465	79438144
Coma	22.73	22.52	6	31773	100643	79611966
Gait inability	22.69	22.52	63	31716	58854	79653755
Pulmonary embolism	22.58	22.52	131	31648	171523	79541086

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L04AC03	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Interleukin inhibitors
FDA MoA	N0000175709	Interleukin 1 Receptor Antagonists
FDA EPC	N0000175710	Interleukin-1 Receptor Antagonist
MeSH PA	D018501	Antirheumatic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Familial Mediterranean fever	indication	12579009	DOID:2987
Rheumatoid arthritis	indication	69896004	DOID:7148
Chronic infantile neurological, cutaneous and articular syndrome	indication	239826001
Still's disease	indication	239920006	DOID:14256
Cryopyrin associated periodic syndrome	indication	430079001
COVID19 pneumonia requiring supplemental oxygen	indication	882785000000000000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Interleukin-1 receptor, type I	Membrane receptor	P14778 Q9NPH3	IL1R1_HUMAN IL1AP_HUMAN	ANTAGONIST	Kd	7.82		IUPHAR	DRUG LABEL

External reference:

ID	Source
D02934	KEGG_DRUG
4021281	VUID
N0000179382	NUI
4021281	VANDF
CHEMBL1201570	ChEMBL_ID
6972	IUPHAR_LIGAND_ID
DB00026	DRUGBANK_ID
352734	RXNORM
16200	MMSL
42416	MMSL
d04775	MMSL
009431	NDDF
009432	NDDF
385549000	SNOMEDCT_US
395279009	SNOMEDCT_US
D053590	MESH_DESCRIPTOR_UI
C0245109	UMLSCUI
7137	INN_ID
90470007	PUBCHEM_CID
9013DUQ28K	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Kineret	HUMAN PRESCRIPTION DRUG LABEL	1	66658-234	INJECTION, SOLUTION	100 mg	SUBCUTANEOUS	BLA	29 sections