anakinra 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
interleukin receptor antagonists and interleukin antagonists 5017 143090-92-0

Description:

MoleculeDescription

Synonyms:

  • anakinra
  • kineret
A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA. As IL-1 levels are elevated in patients with COVID-19, anakinra is currently being investigated for its potential to combat cytokine release syndrome (CRS) in patients with severely ill COVID-19.
  • Molecular weight: 17257.66
  • Formula: C759H1186N208O232S10
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 7115.02
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.10 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 8, 2002 EMA
Nov. 14, 2001 FDA BIOVITRUM AB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 726.33 22.16 1548 28660 1043217 62415597
Red blood cell sedimentation rate abnormal 515.32 22.16 230 29978 19552 63439262
Haemophagocytic lymphohistiocytosis 408.59 22.16 163 30045 10464 63448350
Mobility decreased 371.56 22.16 367 29841 120792 63338022
Bone density decreased 345.98 22.16 159 30049 14453 63444361
Polyarthritis 339.93 22.16 141 30067 10005 63448809
Body height below normal 335.20 22.16 95 30113 2088 63456726
Human antichimeric antibody positive 306.25 22.16 84 30124 1630 63457184
Deformity 304.66 22.16 136 30072 11548 63447266
Off label use 303.59 22.16 850 29358 673612 62785202
Synovitis 302.63 22.16 407 29801 186511 63272303
Oral mucosal exfoliation 299.89 22.16 82 30126 1572 63457242
Adrenal insufficiency 280.43 22.16 147 30061 17768 63441046
Ill-defined disorder 275.55 22.16 261 29947 81494 63377320
Loss of consciousness 273.21 22.16 308 29900 117813 63341001
Drug intolerance 254.12 22.16 494 29714 308167 63150647
Musculoskeletal disorder 252.78 22.16 144 30064 20500 63438314
Joint destruction 251.12 22.16 99 30109 6153 63452661
Wheelchair user 243.12 22.16 97 30111 6222 63452592
Herpes zoster 230.93 22.16 238 29970 82224 63376590
Soft tissue disorder 224.24 22.16 83 30125 4339 63454475
Cutaneous vasculitis 220.66 22.16 86 30122 5183 63453631
Contraindicated product administered 220.16 22.16 381 29827 217267 63241547
Therapeutic product effect decreased 216.40 22.16 354 29854 192833 63265981
Obesity 215.27 22.16 149 30059 29803 63429011
Joint swelling 209.55 22.16 473 29735 327193 63131621
Arthropathy 195.66 22.16 378 29830 234414 63224400
Liver function test abnormal 193.89 22.16 170 30038 48011 63410803
Rheumatoid factor positive 188.07 22.16 216 29992 84190 63374624
Arthritis 183.61 22.16 250 29958 115671 63343143
Therapeutic product effect incomplete 182.11 22.16 259 29949 124797 63334017
Ankle arthroplasty 178.61 22.16 56 30152 1757 63457057
Red blood cell sedimentation rate increased 178.61 22.16 156 30052 43826 63414988
Fine motor skill dysfunction 175.02 22.16 71 30137 4754 63454060
Septic shock 169.90 22.16 183 30025 66446 63392368
Rheumatoid arthritis 158.24 22.16 363 29845 253456 63205358
Drug specific antibody 156.43 22.16 54 30154 2301 63456513
Treatment failure 150.70 22.16 308 29900 198735 63260079
Antibody test positive 149.07 22.16 54 30154 2653 63456161
Pneumonia viral 141.29 22.16 71 30137 7851 63450963
Secretion discharge 140.85 22.16 82 30126 12149 63446665
Nodule 138.06 22.16 99 30109 20927 63437887
Hepatosplenic T-cell lymphoma 133.45 22.16 35 30173 568 63458246
Therapy non-responder 131.32 22.16 171 30037 75730 63383084
Body tinea 128.22 22.16 44 30164 1841 63456973
Ankle operation 123.64 22.16 39 30169 1248 63457566
C-reactive protein abnormal 121.69 22.16 129 30079 45967 63412847
Gastroenteritis viral 120.99 22.16 96 30112 23604 63435210
Immunodeficiency 120.82 22.16 90 30118 20164 63438650
Loss of personal independence in daily activities 117.91 22.16 185 30023 97105 63361709
Impaired quality of life 116.84 22.16 76 30132 13707 63445107
Fall 115.96 22.16 23 30185 392311 63066503
Vasculitic rash 112.74 22.16 37 30171 1347 63457467
Infection 112.25 22.16 299 29909 228874 63229940
Condition aggravated 112.07 22.16 432 29776 401785 63057029
Adenovirus infection 110.78 22.16 47 30161 3524 63455290
Inhibitory drug interaction 107.04 22.16 43 30165 2806 63456008
Arthralgia 103.06 22.16 538 29670 569172 62889642
Spinal stenosis 101.95 22.16 72 30136 14853 63443961
Drug hypersensitivity 101.92 22.16 352 29856 310335 63148479
Infection susceptibility increased 101.51 22.16 44 30164 3477 63455337
Growth failure 101.26 22.16 25 30183 314 63458500
Hepatitis 100.88 22.16 109 30099 39679 63419135
Smear cervix abnormal 98.84 22.16 41 30167 2905 63455909
Psoriasis 96.66 22.16 159 30049 86798 63372016
Foot operation 89.99 22.16 51 30157 7180 63451634
C-reactive protein increased 88.02 22.16 160 30048 94547 63364267
Arthrodesis 87.33 22.16 37 30171 2764 63456050
Asthenia 83.67 22.16 39 30169 383565 63075249
Quality of life decreased 83.21 22.16 52 30156 8751 63450063
Infiltration anaesthesia 82.02 22.16 19 30189 178 63458636
Hypocalcaemia 80.59 22.16 87 30121 31626 63427188
Foot deformity 78.96 22.16 81 30127 27772 63431042
Confusional state 78.44 22.16 10 30198 236370 63222444
Glucose tolerance impaired 78.12 22.16 45 30163 6532 63452282
Juvenile idiopathic arthritis 78.08 22.16 36 30172 3290 63455524
Headache 75.15 22.16 116 30092 633125 62825689
Dyspnoea 74.86 22.16 125 30083 661188 62797626
Sensitivity to weather change 69.03 22.16 43 30165 7194 63451620
Leukopenia 68.56 22.16 128 30080 77162 63381652
Fibromyalgia 67.40 22.16 130 30078 80290 63378524
Short stature 66.66 22.16 21 30187 669 63458145
Hepatotoxicity 66.44 22.16 85 30123 36956 63421858
Complications of bone marrow transplant 65.59 22.16 19 30189 452 63458362
Death 64.88 22.16 50 30158 374331 63084483
Constipation 64.70 22.16 14 30194 224929 63233885
Pulmonary fibrosis 64.66 22.16 87 30121 39722 63419092
Injection site reaction 63.64 22.16 106 30102 58418 63400396
Shoulder arthroplasty 63.05 22.16 33 30175 3969 63454845
Clubbing 62.15 22.16 18 30190 428 63458386
Wound 61.91 22.16 4 30204 163259 63295555
Weight decreased 60.53 22.16 28 30180 276770 63182044
Decreased appetite 60.39 22.16 22 30186 251030 63207784
Purpura 57.84 22.16 46 30162 11339 63447475
Sinusitis 57.75 22.16 18 30190 226635 63232179
Serum ferritin increased 57.13 22.16 36 30172 6146 63452668
Viraemia 56.94 22.16 22 30186 1294 63457520
Bone density increased 56.69 22.16 19 30189 739 63458075
Fatigue 56.39 22.16 225 29983 887803 62571011
Drug ineffective for unapproved indication 56.17 22.16 75 30133 33988 63424826
Anti-neutrophil cytoplasmic antibody positive vasculitis 54.69 22.16 27 30181 2872 63455942
Anxiety 54.14 22.16 18 30190 217523 63241291
Skin disorder 53.37 22.16 68 30140 29439 63429375
Limb discomfort 52.99 22.16 68 30140 29648 63429166
Pneumonia 52.83 22.16 85 30123 456682 63002132
Hypoaesthesia 51.53 22.16 9 30199 168384 63290430
Dehydration 51.47 22.16 10 30198 173344 63285470
Poor quality sleep 51.19 22.16 55 30153 19880 63438934
Muscle spasms 50.84 22.16 7 30201 156143 63302671
Musculoskeletal pain 49.80 22.16 125 30083 92152 63366662
Somnolence 49.61 22.16 12 30196 178673 63280141
Discomfort 48.97 22.16 10 30198 167364 63291450
Serum amyloid A protein increased 48.78 22.16 14 30194 322 63458492
Clear cell renal cell carcinoma 47.57 22.16 20 30188 1465 63457349
Skin fissures 47.41 22.16 41 30167 11347 63447467
Paraesthesia 46.71 22.16 9 30199 156957 63301857
Back disorder 46.55 22.16 40 30168 10977 63447837
General physical health deterioration 46.18 22.16 19 30189 201383 63257431
Abdominal discomfort 45.93 22.16 51 30157 320834 63137980
Human anti-human antibody test 45.05 22.16 14 30194 426 63458388
Febrile neutropenia 44.61 22.16 3 30205 118446 63340368
Joint arthroplasty 44.32 22.16 23 30185 2718 63456096
Epstein-Barr viraemia 44.11 22.16 17 30191 993 63457821
Joint effusion 43.68 22.16 47 30161 17013 63441801
Asthma 43.26 22.16 5 30203 127556 63331258
Toxicity to various agents 42.81 22.16 33 30175 247217 63211597
Oral herpes 42.36 22.16 57 30151 26017 63432797
Interstitial lung disease 42.30 22.16 92 30116 61816 63396998
Varicella zoster virus infection 41.87 22.16 22 30186 2667 63456147
Pain in extremity 41.86 22.16 58 30150 331428 63127386
Drug tolerance 41.70 22.16 31 30177 6918 63451896
Oedema peripheral 41.67 22.16 19 30189 189492 63269322
Hyponatraemia 41.66 22.16 3 30205 111897 63346917
Cough 41.37 22.16 47 30161 292696 63166118
Hair follicle tumour benign 41.15 22.16 13 30195 418 63458396
Pleural effusion 40.94 22.16 117 30091 93093 63365721
Tremor 40.60 22.16 7 30201 132232 63326582
Hepatosplenomegaly 39.61 22.16 21 30187 2593 63456221
Impaired work ability 39.33 22.16 45 30163 17430 63441384
Drug interaction 39.14 22.16 31 30177 229100 63229714
Renal mass 38.78 22.16 20 30188 2333 63456481
Lower respiratory tract infection 38.50 22.16 8 30200 132299 63326515
Exposure during pregnancy 38.46 22.16 13 30195 155534 63303280
Adrenal suppression 38.39 22.16 15 30193 909 63457905
Endodontic procedure 38.24 22.16 22 30186 3185 63455629
Therapeutic response decreased 38.19 22.16 88 30120 61437 63397377
Osteomyelitis 37.94 22.16 54 30154 25966 63432848
Overdose 37.83 22.16 5 30203 115073 63343741
Neuropathy peripheral 37.22 22.16 5 30203 113662 63345152
Palpitations 36.83 22.16 5 30203 112765 63346049
Neck pain 36.45 22.16 93 30115 69225 63389589
Haemoglobin decreased 36.25 22.16 12 30196 145473 63313341
Chest discomfort 35.62 22.16 5 30203 109964 63348850
Drug reaction with eosinophilia and systemic symptoms 35.07 22.16 60 30148 33776 63425038
Scar excision 34.92 22.16 8 30200 71 63458743
Alveolar proteinosis 34.81 22.16 11 30197 354 63458460
Cerebrovascular accident 34.78 22.16 5 30203 108019 63350795
Muscular weakness 34.38 22.16 8 30200 122345 63336469
Alopecia 34.30 22.16 68 30140 337468 63121346
Platelet count decreased 33.83 22.16 7 30201 116115 63342699
Myocardial infarction 33.66 22.16 4 30204 99889 63358925
Hyperlipidaemia 33.66 22.16 44 30164 19527 63439287
Demyelination 33.12 22.16 27 30181 6893 63451921
Graft versus host disease in gastrointestinal tract 32.80 22.16 20 30188 3221 63455593
Hepatic enzyme increased 31.36 22.16 30 30178 202298 63256516
Immune effector cell-associated neurotoxicity syndrome 30.89 22.16 17 30191 2260 63456554
Pneumonia lipoid 30.60 22.16 8 30200 128 63458686
Diaphragm muscle weakness 30.26 22.16 6 30202 24 63458790
Liver function test increased 29.90 22.16 55 30153 32756 63426058
Autoinflammatory disease 29.81 22.16 9 30199 248 63458566
Toothache 29.71 22.16 41 30167 19158 63439656
Laryngeal stenosis 29.54 22.16 13 30195 1065 63457749
Encephalitis viral 29.35 22.16 15 30193 1717 63457097
Human herpesvirus 6 infection 29.29 22.16 18 30190 2939 63455875
Steroid dependence 29.09 22.16 15 30193 1749 63457065
White blood cell count decreased 28.96 22.16 15 30193 139089 63319725
Atrial fibrillation 28.39 22.16 10 30198 116626 63342188
Feeling abnormal 28.05 22.16 18 30190 148374 63310440
Systemic lupus erythematosus 27.94 22.16 35 30173 208883 63249931
Pericarditis 27.68 22.16 14 30194 131565 63327249
Diffuse large B-cell lymphoma 27.61 22.16 24 30184 6688 63452126
Pemphigus 27.60 22.16 28 30180 183698 63275116
Gait disturbance 27.42 22.16 28 30180 183150 63275664
Prescribed underdose 27.35 22.16 50 30158 29639 63429175
Chills 27.12 22.16 10 30198 113368 63345446
Graft versus host disease in skin 27.05 22.16 17 30191 2888 63455926
Post transplant lymphoproliferative disorder 27.00 22.16 21 30187 5010 63453804
Bronchitis 26.72 22.16 13 30195 124922 63333892
Deep vein thrombosis 26.70 22.16 4 30204 83796 63375018
Dry mouth 26.53 22.16 3 30205 77860 63380954
Oxygen saturation decreased 26.51 22.16 5 30203 88580 63370234
Dyspepsia 26.22 22.16 8 30200 102188 63356626
Irritable bowel syndrome 26.10 22.16 4 30204 82408 63376406
Myalgia 26.06 22.16 19 30189 146510 63312304
Cytokine release syndrome 25.90 22.16 33 30175 14281 63444533
Pruritus 25.81 22.16 87 30121 361366 63097448
Borrelia infection 25.45 22.16 8 30200 253 63458561
Gastrooesophageal reflux disease 25.43 22.16 7 30201 95632 63363182
Ankylosing spondylitis 25.32 22.16 28 30180 10446 63448368
Glossodynia 24.94 22.16 29 30179 178847 63279967
Exfoliative rash 24.86 22.16 16 30192 2831 63455983
Balance disorder 24.77 22.16 5 30203 84417 63374397
Soft tissue swelling 24.71 22.16 12 30196 1232 63457582
Medical device site discomfort 24.62 22.16 8 30200 282 63458532
Embolism 24.25 22.16 24 30184 7882 63450932
Drug abuse 24.19 22.16 3 30205 72515 63386299
Impaired gastric emptying 23.92 22.16 27 30181 10305 63448509
Tumour necrosis factor receptor-associated periodic syndrome 23.70 22.16 6 30202 84 63458730
Mouth ulceration 23.65 22.16 50 30158 32934 63425880
Infusion related reaction 23.62 22.16 51 30157 245470 63213344
Hyperferritinaemia 22.91 22.16 7 30201 201 63458613
Finger deformity 22.81 22.16 23 30185 7722 63451092
Maternal exposure during pregnancy 22.62 22.16 44 30164 220018 63238796
Fasciitis 22.61 22.16 9 30199 573 63458241
Bradycardia 22.20 22.16 4 30204 73223 63385591

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Apparent death 990.06 32.31 227 10156 3417 34943131
Diverticulitis 663.73 32.31 242 10141 19762 34926786
Off label use 624.37 32.31 686 9697 418838 34527710
Joint swelling 436.47 32.31 252 10131 59638 34886910
Deep vein thrombosis 411.27 32.31 250 10133 64998 34881550
Pulmonary thrombosis 378.86 32.31 124 10259 7283 34939265
Drug ineffective 377.05 32.31 559 9824 456192 34490356
Red blood cell sedimentation rate increased 349.18 32.31 123 10260 9039 34937509
Pulmonary embolism 329.68 32.31 246 10137 89500 34857048
Terminal state 293.84 32.31 88 10295 3846 34942702
Renal failure 277.82 32.31 261 10122 130296 34816252
C-reactive protein abnormal 243.12 32.31 93 10290 8617 34937931
Contraindicated product administered 195.93 32.31 105 10278 21376 34925172
Pain 193.97 32.31 269 10114 204406 34742142
Drug specific antibody present 192.41 32.31 61 10322 3224 34943324
Acne cystic 177.40 32.31 39 10344 475 34946073
Thrombosis 168.65 32.31 131 10252 50327 34896221
Photosensitivity reaction 156.76 32.31 72 10311 10522 34936026
Intestinal sepsis 151.33 32.31 36 10347 635 34945913
Joint arthroplasty 151.08 32.31 38 10345 853 34945695
Haemophagocytic lymphohistiocytosis 145.82 32.31 73 10310 12900 34933648
Drug use disorder 139.72 32.31 51 10332 4140 34942408
Sepsis 134.21 32.31 203 10180 166358 34780190
C-reactive protein increased 131.84 32.31 117 10266 53981 34892567
Drug intolerance 120.29 32.31 116 10267 59454 34887094
Intentional product use issue 97.90 32.31 104 10279 59712 34886836
Herpes zoster 97.16 32.31 81 10302 34318 34912230
Gait inability 92.08 32.31 64 10319 20694 34925854
Arthropathy 90.08 32.31 70 10313 26837 34919711
Stent placement 82.97 32.31 37 10346 5041 34941507
Drug reaction with eosinophilia and systemic symptoms 79.55 32.31 71 10312 32941 34913607
Urticaria 79.10 32.31 95 10288 62282 34884266
Drug ineffective for unapproved indication 77.87 32.31 61 10322 23654 34922894
Treatment failure 74.27 32.31 80 10303 46617 34899931
Knee arthroplasty 72.35 32.31 38 10345 7406 34939142
Interstitial lung disease 70.89 32.31 92 10291 65190 34881358
Stomatitis 69.66 32.31 74 10309 42440 34904108
Meningitis viral 66.43 32.31 20 10363 887 34945661
Propionibacterium infection 63.78 32.31 15 10368 251 34946297
Dyspnoea 63.31 32.31 17 10366 376765 34569783
Drug hypersensitivity 61.58 32.31 96 10287 80433 34866115
Diarrhoea 59.39 32.31 21 10362 389891 34556657
Drug dependence 54.23 32.31 50 10333 24167 34922381
Feeling abnormal 47.78 32.31 75 10308 63160 34883388
Central nervous system lymphoma 47.66 32.31 16 10367 1012 34945536
Post transplant lymphoproliferative disorder 46.08 32.31 27 10356 6501 34940047
Therapeutic product effect decreased 45.78 32.31 54 10329 34689 34911859
Drug interaction 44.46 32.31 7 10376 225939 34720609
Cytomegalovirus hepatitis 41.77 32.31 12 10371 451 34946097
Injection site reaction 41.63 32.31 33 10350 13000 34933548
Myocardial infarction 40.50 32.31 102 10281 120983 34825565
Rheumatoid arthritis 38.55 32.31 52 10331 38186 34908362
Product use in unapproved indication 37.24 32.31 97 10286 117402 34829146
Immobilisation syndrome 36.66 32.31 10 10373 310 34946238
Varicella 36.58 32.31 15 10368 1662 34944886
Fatigue 34.12 32.31 36 10347 370617 34575931
Diffuse large B-cell lymphoma 33.31 32.31 23 10360 7347 34939201

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 799.02 22.52 1483 30296 1079430 78633179
Off label use 643.42 22.52 1225 30554 905990 78806619
Red blood cell sedimentation rate abnormal 498.84 22.52 217 31562 20746 79691863
Drug intolerance 454.56 22.52 542 31237 263577 79449032
Red blood cell sedimentation rate increased 396.67 22.52 240 31539 45702 79666907
Contraindicated product administered 370.38 22.52 381 31398 157157 79555452
Haemophagocytic lymphohistiocytosis 338.45 22.52 168 31611 21669 79690940
Apparent death 335.18 22.52 97 31682 2768 79709841
Joint swelling 328.65 22.52 484 31295 288162 79424447
Synovitis 326.48 22.52 349 31430 150385 79562224
Polyarthritis 325.50 22.52 137 31642 12065 79700544
Oral mucosal exfoliation 318.14 22.52 81 31698 1404 79711205
Human antichimeric antibody positive 310.11 22.52 81 31698 1560 79711049
C-reactive protein abnormal 309.00 22.52 209 31570 48158 79664451
Body height below normal 305.98 22.52 84 31695 1969 79710640
Arthropathy 288.69 22.52 354 31425 176757 79535852
Bone density decreased 284.69 22.52 128 31651 13219 79699390
Therapeutic product effect decreased 277.57 22.52 334 31445 163529 79549080
Treatment failure 270.17 22.52 336 31443 170150 79542459
Rheumatoid factor positive 262.56 22.52 206 31573 59633 79652976
Joint destruction 262.20 22.52 96 31683 5829 79706780
Rheumatoid arthritis 258.09 22.52 364 31415 208106 79504503
Herpes zoster 229.18 22.52 231 31548 92852 79619757
Pulmonary thrombosis 229.05 22.52 107 31672 12064 79700545
Wheelchair user 219.23 22.52 85 31694 6047 79706562
Terminal state 215.54 22.52 79 31700 4810 79707799
Adrenal insufficiency 210.83 22.52 135 31644 28352 79684257
Cutaneous vasculitis 191.58 22.52 84 31695 8168 79704441
Obesity 187.46 22.52 136 31643 34989 79677620
C-reactive protein increased 175.58 22.52 236 31543 128791 79583818
Mobility decreased 171.66 22.52 227 31552 121948 79590661
Fine motor skill dysfunction 166.10 22.52 67 31712 5290 79707319
Drug hypersensitivity 166.05 22.52 367 31412 298549 79414060
Drug specific antibody 163.96 22.52 55 31724 2573 79710036
Drug specific antibody present 161.87 22.52 70 31709 6582 79706027
Deformity 158.03 22.52 77 31702 9528 79703081
Musculoskeletal disorder 154.64 22.52 100 31679 21348 79691261
Joint arthroplasty 150.03 22.52 52 31727 2688 79709921
Arthritis 142.53 22.52 201 31578 114679 79597930
Nodule 138.80 22.52 96 31683 22898 79689711
Ill-defined disorder 136.18 22.52 149 31630 65726 79646883
Secretion discharge 136.08 22.52 81 31698 14941 79697668
Body tinea 132.51 22.52 43 31736 1811 79710798
Septic shock 132.27 22.52 201 31578 122600 79590009
Soft tissue disorder 130.19 22.52 50 31729 3465 79709144
Immunodeficiency 126.99 22.52 89 31690 21679 79690930
Fall 124.87 22.52 22 31757 487607 79225002
Antibody test positive 122.64 22.52 45 31734 2747 79709862
Dyspnoea 119.63 22.52 100 31679 856925 78855684
Gastroenteritis viral 118.69 22.52 90 31689 24741 79687868
Therapy non-responder 115.20 22.52 162 31617 92143 79620466
Therapeutic product effect incomplete 114.89 22.52 204 31575 141441 79571168
Condition aggravated 113.02 22.52 446 31333 500678 79211931
Ankle arthroplasty 111.56 22.52 36 31743 1489 79711120
Ankle operation 110.32 22.52 33 31746 1058 79711551
Smear cervix abnormal 108.17 22.52 40 31739 2496 79710113
Pneumonia viral 106.12 22.52 58 31721 9100 79703509
Impaired quality of life 105.98 22.52 68 31711 14318 79698291
Spinal stenosis 104.99 22.52 70 31709 15721 79696888
Drug ineffective for unapproved indication 104.33 22.52 115 31664 51123 79661486
Diverticulitis 103.91 22.52 109 31670 45827 79666782
Infection susceptibility increased 103.30 22.52 43 31736 3678 79708931
Intestinal sepsis 103.20 22.52 30 31749 869 79711740
Vasculitic rash 98.90 22.52 36 31743 2148 79710461
Confusional state 96.85 22.52 8 31771 317989 79394620
Inhibitory drug interaction 92.69 22.52 42 31737 4411 79708198
Hepatosplenic T-cell lymphoma 90.70 22.52 27 31752 851 79711758
Toxicity to various agents 90.13 22.52 28 31751 421512 79291097
Psoriasis 89.93 22.52 142 31637 89445 79623164
Liver function test abnormal 83.17 22.52 115 31664 64360 79648249
Foot deformity 80.76 22.52 71 31708 24003 79688606
Loss of personal independence in daily activities 78.37 22.52 144 31635 102436 79610173
Infiltration anaesthesia 76.61 22.52 17 31762 157 79712452
Interstitial lung disease 76.07 22.52 150 31629 112450 79600159
Loss of consciousness 74.37 22.52 189 31590 167754 79544855
Glucose tolerance impaired 74.28 22.52 44 31735 8040 79704569
Drug use disorder 74.08 22.52 45 31734 8606 79704003
Anxiety 73.62 22.52 7 31772 248505 79464104
Infection 73.02 22.52 237 31542 241475 79471134
Hepatitis 72.78 22.52 100 31679 55627 79656982
Juvenile idiopathic arthritis 71.85 22.52 36 31743 4727 79707882
Drug interaction 71.81 22.52 38 31741 415145 79297464
Short stature 69.53 22.52 21 31758 696 79711913
Post transplant lymphoproliferative disorder 69.50 22.52 48 31731 11416 79701193
Photosensitivity reaction 68.26 22.52 61 31718 21066 79691543
Decreased appetite 67.54 22.52 26 31753 342392 79370217
Constipation 65.70 22.52 16 31763 283034 79429575
Foot operation 65.57 22.52 36 31743 5697 79706912
Diffuse large B-cell lymphoma 64.70 22.52 47 31732 12102 79700507
Intentional product use issue 64.05 22.52 168 31611 151944 79560665
Complications of bone marrow transplant 62.99 22.52 19 31760 627 79711982
Pulmonary fibrosis 61.93 22.52 82 31697 44030 79668579
Injection site reaction 60.81 22.52 91 31688 54694 79657915
Arthrodesis 60.76 22.52 26 31753 2381 79710228
Hypocalcaemia 59.86 22.52 86 31693 49838 79662771
Pneumonia 59.33 22.52 108 31671 660138 79052471
Bone density increased 58.32 22.52 19 31760 810 79711799
General physical health deterioration 57.51 22.52 19 31760 275219 79437390
Somnolence 56.46 22.52 13 31766 238968 79473641
Propionibacterium infection 56.32 22.52 15 31764 312 79712297
Joint effusion 56.21 22.52 51 31728 17963 79694646
Dehydration 55.73 22.52 15 31764 248172 79464437
Skin disorder 55.38 22.52 68 31711 33875 79678734
Oedema peripheral 55.25 22.52 16 31763 252272 79460337
Fibromyalgia 55.14 22.52 95 31684 64245 79648364
Immune effector cell-associated neurotoxicity syndrome 54.17 22.52 32 31747 5816 79706793
Thrombosis 53.16 22.52 109 31670 83991 79628618
Arthralgia 52.85 22.52 399 31380 571404 79141205
Fatigue 52.80 22.52 192 31587 929535 78783074
Anti-neutrophil cytoplasmic antibody positive vasculitis 52.79 22.52 27 31752 3702 79708907
Quality of life decreased 52.53 22.52 39 31740 10381 79702228
Overdose 52.45 22.52 6 31773 184200 79528409
Drug reaction with eosinophilia and systemic symptoms 50.08 22.52 91 31688 64153 79648456
Knee arthroplasty 49.66 22.52 73 31706 43175 79669434
Platelet count decreased 49.26 22.52 9 31770 194655 79517954
Hypoaesthesia 48.28 22.52 7 31772 179345 79533264
Human anti-human antibody test 48.04 22.52 14 31765 409 79712200
Poor quality sleep 47.98 22.52 52 31727 22670 79689939
Death 47.94 22.52 96 31683 566418 79146191
Tremor 47.29 22.52 6 31773 170077 79542532
Paraesthesia 47.19 22.52 7 31772 176316 79536293
Skin fissures 46.76 22.52 40 31739 13033 79699576
Back disorder 46.76 22.52 38 31741 11540 79701069
Asthenia 45.64 22.52 84 31695 511605 79201004
Meningitis viral 45.37 22.52 20 31759 1968 79710641
Endodontic procedure 45.14 22.52 22 31757 2721 79709888
Neuropathy peripheral 44.56 22.52 3 31776 141302 79571307
Limb discomfort 44.47 22.52 60 31719 32790 79679819
Muscle spasms 44.38 22.52 8 31771 174722 79537887
Cerebrovascular accident 44.36 22.52 5 31774 155287 79557322
Stent placement 43.57 22.52 29 31750 6491 79706118
Oral herpes 43.18 22.52 54 31725 27400 79685209
Cough 42.68 22.52 50 31729 366739 79345870
Malignant neoplasm progression 42.55 22.52 3 31776 135987 79576622
Hair follicle tumour benign 42.31 22.52 13 31766 457 79712152
Pain 42.25 22.52 447 31332 703355 79009254
Transplant failure 41.96 22.52 25 31754 4616 79707993
Therapeutic response decreased 41.48 22.52 86 31693 66767 79645842
Shoulder arthroplasty 41.41 22.52 22 31757 3260 79709349
Serum ferritin increased 41.21 22.52 33 31746 9814 79702795
Weight decreased 40.71 22.52 49 31730 355149 79357460
Chest discomfort 40.57 22.52 4 31775 138040 79574569
Drug tolerance 40.47 22.52 31 31748 8644 79703965
Clear cell renal cell carcinoma 40.42 22.52 20 31759 2556 79710053
Sensitivity to weather change 40.30 22.52 30 31749 8017 79704592
Cytopenia 40.18 22.52 45 31734 20338 79692271
Purpura 40.03 22.52 44 31735 19483 79693126
Asthma 39.48 22.52 4 31775 135091 79577518
Atrial fibrillation 39.03 22.52 15 31764 197871 79514738
Palpitations 39.02 22.52 3 31776 126607 79586002
Impaired work ability 38.03 22.52 43 31736 19638 79692971
Sepsis 37.07 22.52 208 31571 269220 79443389
Serum amyloid A protein increased 36.70 22.52 11 31768 355 79712254
Scar excision 36.54 22.52 8 31771 69 79712540
Growth failure 35.96 22.52 10 31769 246 79712363
Renal mass 35.53 22.52 20 31759 3320 79709289
Wheezing 35.30 22.52 3 31776 116661 79595948
Wound 35.12 22.52 3 31776 116176 79596433
Adrenal suppression 34.95 22.52 15 31764 1384 79711225
Bradycardia 34.87 22.52 6 31773 135551 79577058
Hyperkalaemia 34.45 22.52 3 31776 114395 79598214
Toothache 34.19 22.52 41 31738 19929 79692680
Autoinflammatory disease 33.63 22.52 10 31769 314 79712295
Cytokine release syndrome 33.29 22.52 55 31724 35943 79676666
Oxygen saturation decreased 32.57 22.52 6 31773 129041 79583568
Product use in unapproved indication 32.29 22.52 190 31589 250169 79462440
Sinusitis 32.15 22.52 19 31760 195482 79517127
Cytomegalovirus hepatitis 32.09 22.52 12 31767 772 79711837
Laryngeal stenosis 31.64 22.52 13 31766 1075 79711534
Pain in extremity 31.45 22.52 61 31718 364477 79348132
Blister 31.37 22.52 5 31774 119471 79593138
Rhabdomyolysis 30.27 22.52 3 31776 103128 79609481
Pruritus 29.92 22.52 71 31708 394577 79318032
Febrile neutropenia 29.62 22.52 29 31750 230970 79481639
Clubbing 29.47 22.52 11 31768 704 79711905
Deep vein thrombosis 29.04 22.52 110 31669 120809 79591800
Headache 29.04 22.52 148 31631 653624 79058985
Hepatosplenomegaly 29.00 22.52 22 31757 6047 79706562
Chills 28.65 22.52 14 31765 160220 79552389
Lower respiratory tract infection 28.63 22.52 8 31771 129212 79583397
Hyperlipidaemia 28.46 22.52 43 31736 26050 79686559
Dysphagia 28.13 22.52 7 31772 122129 79590480
Medical device site discomfort 27.95 22.52 8 31771 219 79712390
Central nervous system lymphoma 27.92 22.52 15 31764 2274 79710335
Depressed level of consciousness 27.88 22.52 3 31776 96649 79615960
Pleural effusion 27.66 22.52 123 31656 145139 79567470
Discomfort 27.42 22.52 8 31771 125609 79587000
Finger deformity 27.00 22.52 23 31756 7451 79705158
Borrelia infection 26.97 22.52 8 31771 249 79712360
Product use issue 26.89 22.52 159 31620 209663 79502946
Agitation 26.57 22.52 4 31775 99711 79612898
Erythema 26.42 22.52 30 31749 223260 79489349
Balance disorder 26.27 22.52 4 31775 98853 79613756
Visual impairment 26.22 22.52 3 31776 92128 79620481
Hand deformity 26.17 22.52 96 31683 103823 79608786
White blood cell count decreased 26.09 22.52 22 31757 188266 79524343
Steroid dependence 25.97 22.52 15 31764 2615 79709994
Acute kidney injury 25.73 22.52 113 31666 519291 79193318
Mouth ulceration 25.72 22.52 51 31728 38343 79674266
Blood glucose increased 25.69 22.52 7 31772 114968 79597641
Bronchitis 25.59 22.52 10 31769 130634 79581975
Demyelination 25.59 22.52 23 31756 8000 79704609
Electrocardiogram QT prolonged 25.58 22.52 3 31776 90383 79622226
Hyperferritinaemia 25.55 22.52 10 31769 729 79711880
Alveolar proteinosis 24.91 22.52 10 31769 779 79711830
Gastrointestinal haemorrhage 24.79 22.52 14 31765 147705 79564904
Tumour necrosis factor receptor-associated periodic syndrome 24.76 22.52 6 31773 84 79712525
Prescribed underdose 24.52 22.52 43 31736 29471 79683138
Varicella 24.46 22.52 15 31764 2917 79709692
Tooth disorder 24.14 22.52 40 31739 26193 79686416
Joint injury 23.92 22.52 44 31735 31291 79681318
Dyspepsia 23.58 22.52 7 31772 108680 79603929
Product dose omission issue 23.51 22.52 39 31740 247498 79465111
Hyperhidrosis 23.16 22.52 16 31763 151476 79561133
Myalgia 23.00 22.52 24 31755 185617 79526992
Exposure during pregnancy 22.89 22.52 6 31773 101126 79611483
Urinary tract infection 22.75 22.52 47 31732 274465 79438144
Coma 22.73 22.52 6 31773 100643 79611966
Gait inability 22.69 22.52 63 31716 58854 79653755
Pulmonary embolism 22.58 22.52 131 31648 171523 79541086

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AC03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
FDA MoA N0000175709 Interleukin 1 Receptor Antagonists
FDA EPC N0000175710 Interleukin-1 Receptor Antagonist
MeSH PA D018501 Antirheumatic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Familial Mediterranean fever indication 12579009 DOID:2987
Rheumatoid arthritis indication 69896004 DOID:7148
Chronic infantile neurological, cutaneous and articular syndrome indication 239826001
Still's disease indication 239920006 DOID:14256
Cryopyrin associated periodic syndrome indication 430079001
COVID19 pneumonia requiring supplemental oxygen indication 882785000000000000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Interleukin-1 receptor, type I Membrane receptor ANTAGONIST Kd 7.82 IUPHAR DRUG LABEL

External reference:

IDSource
D02934 KEGG_DRUG
4021281 VUID
N0000179382 NUI
4021281 VANDF
CHEMBL1201570 ChEMBL_ID
6972 IUPHAR_LIGAND_ID
DB00026 DRUGBANK_ID
352734 RXNORM
16200 MMSL
42416 MMSL
d04775 MMSL
009431 NDDF
009432 NDDF
385549000 SNOMEDCT_US
395279009 SNOMEDCT_US
D053590 MESH_DESCRIPTOR_UI
C0245109 UMLSCUI
7137 INN_ID
90470007 PUBCHEM_CID
9013DUQ28K UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Kineret HUMAN PRESCRIPTION DRUG LABEL 1 66658-234 INJECTION, SOLUTION 100 mg SUBCUTANEOUS BLA 29 sections