sarilumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
human origin 5237 1189541-98-7

Description:

MoleculeDescription

Synonyms:

  • sarilumab
  • REGN88
  • SAR153191
  • kevzara
Sarilumab is a human recombinant monoclonal antibody of the IgG1 subclass. Sarilumab is produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture. Sarilumab binds to both soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R), and has been shown to inhibit IL-6-mediated signaling through these receptors. IL-6 is a pleiotropic pro-inflammatory cytokine produced by a variety of cell types including T- and B-cells, lymphocytes, monocytes, and fibroblasts. IL-6 has been shown to be involved in diverse physiological processes such as T-cell activation, induction of immunoglobulin secretion, initiation of hepatic acute phase protein synthesis, and stimulation of hematopoietic precursor cell proliferation and differentiation. IL-6 is also produced by synovial and endothelial cells leading to local production of IL-6 in joints affected by inflammatory processes such as rheumatoid arthritis. Based on encouraging results in China with a similar drug, tocilizumab, a phase 2/3 US study evaluating efficacy and safety of sarilumab in patients hospitalized with severe COVID-19 was performed. At the moment, there are insufficient data to recommend either for or against use of sarilumab for hospitalized patients with COVID-19.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
14.30 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 23, 2017 EMA sanofi-aventis groupe
May 22, 2017 FDA SANOFI SYNTHELABO
Sept. 27, 2017 PMDA SANOFI KK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid factor positive 1497.72 53.89 1049 76156 83357 63328460
Anti-cyclic citrullinated peptide antibody positive 1453.43 53.89 1171 76034 115041 63296776
Wound 1205.92 53.89 1223 75982 162040 63249777
Pericarditis 1188.35 53.89 1101 76104 130478 63281339
Hand deformity 1187.75 53.89 1200 76005 158257 63253560
Hepatic enzyme increased 1152.73 53.89 1321 75884 201007 63210810
Synovitis 1139.04 53.89 1264 75941 185654 63226163
Glossodynia 1106.00 53.89 1219 75986 177657 63234160
Pemphigus 1063.86 53.89 1210 75995 182516 63229301
Discomfort 1021.30 53.89 1133 76072 166241 63245576
Joint swelling 1009.76 53.89 1584 75621 326082 63085735
Systemic lupus erythematosus 995.81 53.89 1246 75959 207672 63204145
Infusion related reaction 797.15 53.89 1217 75988 244304 63167513
Arthropathy 785.12 53.89 1180 76025 233612 63178205
Helicobacter infection 753.97 53.89 733 76472 92052 63319765
Duodenal ulcer perforation 723.69 53.89 697 76508 86512 63325305
Drug intolerance 705.95 53.89 1308 75897 307353 63104464
Swelling 699.89 53.89 1222 75983 274156 63137661
Abdominal discomfort 678.41 53.89 1315 75890 319570 63092247
Treatment failure 674.45 53.89 1007 76198 198036 63213781
Alopecia 671.12 53.89 1348 75857 336188 63075629
Rheumatic fever 601.28 53.89 464 76741 42647 63369170
Hypersensitivity 593.46 53.89 1179 76026 291506 63120311
Contraindicated product administered 572.22 53.89 981 76224 216667 63195150
Product use issue 552.40 53.89 973 76232 219547 63192270
Maternal exposure during pregnancy 544.80 53.89 966 76239 219096 63192721
Hip arthroplasty 543.74 53.89 456 76749 47190 63364627
Swollen joint count increased 526.79 53.89 399 76806 35655 63376162
Blood cholesterol increased 487.37 53.89 586 76619 93446 63318371
Knee arthroplasty 456.42 53.89 437 76768 53769 63358048
Type 2 diabetes mellitus 451.21 53.89 468 76737 63400 63348417
Blister 440.78 53.89 658 76547 129156 63282661
Condition aggravated 425.31 53.89 1260 75945 400957 63010860
General physical health deterioration 401.06 53.89 806 76399 200596 63211221
Therapeutic product effect decreased 365.47 53.89 757 76448 192430 63219387
Death 353.18 53.89 27 77178 374354 63037463
Pain 344.64 53.89 1789 75416 738839 62672978
Injury 314.93 53.89 416 76789 72831 63338986
Rash 309.16 53.89 1423 75782 559448 62852369
Musculoskeletal stiffness 305.02 53.89 685 76520 183933 63227884
Anaemia 298.25 53.89 14 77191 293416 63118401
Hypotension 290.72 53.89 9 77196 272595 63139222
Acute kidney injury 287.20 53.89 7 77198 263408 63148409
Fall 279.66 53.89 67 77138 392267 63019550
Toxicity to various agents 271.74 53.89 6 77199 247244 63164573
Drug interaction 258.15 53.89 4 77201 229127 63182690
Liver injury 245.23 53.89 334 76871 60186 63351631
Mobility decreased 238.54 53.89 483 76722 120676 63291141
Product use in unapproved indication 228.86 53.89 602 76603 178478 63233339
Intentional product use issue 220.57 53.89 483 76722 127409 63284408
Adverse event 214.21 53.89 332 76873 67227 63344590
Fibromyalgia 213.98 53.89 365 76840 80055 63331762
Constipation 212.55 53.89 16 77189 224927 63186890
Prescribed overdose 212.33 53.89 234 76971 33919 63377898
Adverse drug reaction 204.49 53.89 356 76849 79358 63332459
Folliculitis 201.56 53.89 330 76875 69987 63341830
Cough 198.86 53.89 55 77150 292688 63119129
Irritable bowel syndrome 195.91 53.89 356 76849 82056 63329761
Somnolence 186.53 53.89 7 77198 178678 63233139
Arthralgia 186.14 53.89 1256 75949 568454 62843363
Drug ineffective 185.70 53.89 2009 75196 1042756 62369061
Live birth 179.38 53.89 187 77018 25443 63386374
Muscle injury 175.67 53.89 298 76907 65047 63346770
Back pain 173.18 53.89 53 77152 264092 63147725
Psoriatic arthropathy 173.14 53.89 359 76846 91161 63320656
Diarrhoea 167.73 53.89 391 76814 714975 62696842
Dyspnoea 161.87 53.89 353 76852 660960 62750857
Blood pressure increased 157.49 53.89 10 77195 162052 63249765
Deep vein thrombosis postoperative 155.39 53.89 121 77084 11248 63400569
Urinary tract infection 151.72 53.89 66 77139 264618 63147199
Retinitis 150.82 53.89 94 77111 6102 63405715
Haemoglobin decreased 141.29 53.89 9 77196 145476 63266341
Sleep disorder due to general medical condition, insomnia type 140.16 53.89 238 76967 51979 63359838
Seizure 139.08 53.89 5 77200 132629 63279188
Tremor 135.23 53.89 6 77199 132233 63279584
Adjustment disorder with depressed mood 133.84 53.89 106 77099 10098 63401719
Lip dry 132.51 53.89 126 77079 15344 63396473
Thrombocytopenia 131.41 53.89 15 77190 151142 63260675
Renal failure 128.60 53.89 3 77202 117649 63294168
Facet joint syndrome 127.77 53.89 111 77094 12027 63399790
Dislocation of vertebra 126.99 53.89 96 77109 8539 63403278
Myalgia 126.24 53.89 15 77190 146514 63265303
Autoimmune disorder 121.40 53.89 126 77079 17051 63394766
Atrial fibrillation 120.23 53.89 5 77200 116631 63295186
Sepsis 119.55 53.89 21 77184 153102 63258715
Disease progression 118.00 53.89 8 77197 122750 63289067
Feeling abnormal 116.62 53.89 20 77185 148372 63263445
Loss of consciousness 115.61 53.89 7 77198 118114 63293703
Pulmonary embolism 111.00 53.89 8 77197 116676 63295141
Nausea 109.18 53.89 603 76602 853868 62557949
Joint range of motion decreased 107.85 53.89 163 77042 32265 63379552
Impaired healing 107.47 53.89 321 76884 102221 63309596
Peripheral venous disease 106.63 53.89 112 77093 15365 63396452
Respiratory failure 102.91 53.89 5 77200 101853 63309964
Hypokalaemia 102.05 53.89 6 77199 103798 63308019
Palpitations 101.05 53.89 10 77195 112760 63299057
Myocardial infarction 100.61 53.89 5 77200 99888 63311929
Weight decreased 100.58 53.89 113 77092 276685 63135132
Ill-defined disorder 100.37 53.89 271 76934 81484 63330333
Asthenia 100.13 53.89 197 77008 383407 63028410
Neutropenia 99.64 53.89 44 77161 174961 63236856
Hypercholesterolaemia 99.14 53.89 126 77079 21208 63390609
Hyperhidrosis 98.12 53.89 9 77196 107827 63303990
Lupus vulgaris 97.93 53.89 71 77134 5923 63405894
Cerebrovascular accident 95.70 53.89 10 77195 108014 63303803
Breast cancer stage III 95.50 53.89 88 77117 10298 63401519
Cardiac failure congestive 95.14 53.89 4 77201 92429 63319388
Hepatic cirrhosis 94.86 53.89 133 77072 24601 63387216
Oxygen saturation decreased 94.05 53.89 3 77202 88582 63323235
Dysphagia 94.05 53.89 3 77202 88582 63323235
Heart rate increased 94.02 53.89 5 77200 94233 63317584
Chest discomfort 92.89 53.89 12 77193 109957 63301860
Pleural effusion 92.82 53.89 5 77200 93205 63318612
Aspartate aminotransferase increased 92.60 53.89 4 77201 90273 63321544
Alanine aminotransferase increased 90.92 53.89 10 77195 103760 63308057
Chills 87.51 53.89 16 77189 113362 63298455
Grip strength decreased 87.20 53.89 121 77084 22166 63389651
Pneumonia 85.53 53.89 278 76927 456489 62955328
Vision blurred 85.46 53.89 7 77198 91917 63319900
Overdose 85.12 53.89 18 77187 115060 63296757
Abdominal pain 82.47 53.89 144 77061 293312 63118505
Cardiac failure 82.29 53.89 7 77198 89135 63322682
Platelet count decreased 82.21 53.89 20 77185 116102 63295715
Balance disorder 79.68 53.89 6 77199 84416 63327401
Erythema 78.94 53.89 59 77146 175692 63236125
Pyrexia 78.29 53.89 301 76904 470177 62941640
Bone erosion 78.18 53.89 102 77103 17615 63394202
Flushing 78.11 53.89 3 77202 75084 63336733
Joint dislocation 77.98 53.89 105 77100 18695 63393122
Drug tolerance decreased 77.74 53.89 101 77104 17372 63394445
Anti-cyclic citrullinated peptide antibody 77.66 53.89 65 77140 6693 63405124
Lupus-like syndrome 76.93 53.89 94 77111 15201 63396616
Deep vein thrombosis 76.22 53.89 7 77198 83793 63328024
Renal impairment 76.19 53.89 9 77196 88346 63323471
Epistaxis 75.33 53.89 3 77202 72722 63339095
Exostosis 74.45 53.89 100 77105 17762 63394055
Blood glucose increased 73.56 53.89 8 77197 83748 63328069
Tachycardia 73.33 53.89 26 77179 118130 63293687
Lower limb fracture 72.51 53.89 116 77089 24105 63387712
Loss of personal independence in daily activities 72.07 53.89 271 76934 97019 63314798
Pancytopenia 69.99 53.89 16 77189 96917 63314900
Joint stiffness 69.66 53.89 156 77049 41713 63370104
Oral discomfort 69.56 53.89 70 77135 9131 63402686
Stomatitis 69.30 53.89 343 76862 138382 63273435
Laryngitis 69.21 53.89 94 77111 16873 63394944
Osteoarthritis 68.50 53.89 263 76942 95080 63316737
Anxiety 68.41 53.89 99 77106 217442 63194375
Influenza 67.33 53.89 24 77181 108698 63303119
Bronchitis 67.12 53.89 34 77171 124901 63286916
C-reactive protein 66.80 53.89 52 77153 4830 63406987
Insomnia 66.67 53.89 99 77106 215153 63196664
Walking aid user 65.84 53.89 73 77132 10644 63401173
Wound infection 64.73 53.89 103 77102 21307 63390510
Prescribed underdose 63.93 53.89 123 77082 29566 63382251
Wrong technique in product usage process 63.15 53.89 3 77202 62337 63349480
Vomiting 62.23 53.89 412 76793 559205 62852612
Cardio-respiratory arrest 60.37 53.89 3 77202 59956 63351861
Haemorrhage 58.56 53.89 4 77201 61018 63350799
Dyspnoea exertional 57.73 53.89 4 77201 60298 63351519
Swelling face 55.89 53.89 6 77199 63469 63348348
C-reactive protein abnormal 55.74 53.89 152 77053 45944 63365873
Stress 55.13 53.89 8 77197 67159 63344658
Injection site reaction 54.60 53.89 176 77029 58348 63353469
Pulmonary oedema 54.45 53.89 3 77202 54870 63356947
Hallucination 54.38 53.89 3 77202 54814 63357003
Contusion 54.24 53.89 340 76865 149704 63262113

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Joint swelling 142.86 38.79 66 1666 59824 34895375
Pain 139.05 38.79 99 1633 204576 34750623
Drug ineffective 114.39 38.79 125 1607 456626 34498573
Arthralgia 107.71 38.79 79 1653 169962 34785237
Injection site pruritus 45.76 38.79 16 1716 6967 34948232
Product use in unapproved indication 45.21 38.79 41 1691 117458 34837741

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid factor positive 1233.14 54.53 671 55373 59168 79629176
Anti-cyclic citrullinated peptide antibody positive 1221.75 54.53 748 55296 82395 79605949
Pemphigus 1170.25 54.53 778 55266 98804 79589540
Glossodynia 1153.60 54.53 782 55262 102555 79585789
Hand deformity 1147.23 54.53 781 55263 103138 79585206
Wound 1144.27 54.53 814 55230 115365 79572979
Systemic lupus erythematosus 1131.83 54.53 822 55222 120327 79568017
Pericarditis 1067.27 54.53 748 55296 103488 79584856
Synovitis 976.87 54.53 824 55220 149910 79538434
Discomfort 906.22 54.53 731 55313 124886 79563458
Hepatic enzyme increased 903.36 54.53 857 55187 181753 79506591
Joint swelling 890.54 54.53 1053 54991 287593 79400751
Arthropathy 809.51 54.53 796 55248 176315 79512029
Alopecia 763.05 54.53 874 55170 230481 79457863
Swelling 694.78 54.53 807 55237 215904 79472440
Helicobacter infection 691.43 54.53 491 55553 69213 79619131
Duodenal ulcer perforation 681.34 54.53 477 55567 65734 79622610
Abdominal discomfort 653.59 54.53 841 55203 249886 79438458
Maternal exposure during pregnancy 625.86 54.53 615 55429 135923 79552421
Contraindicated product administered 624.53 54.53 656 55388 156882 79531462
Rheumatic fever 595.67 54.53 323 55721 28202 79660142
Treatment failure 585.15 54.53 658 55386 169828 79518516
Drug intolerance 581.45 54.53 816 55228 263303 79425041
Infusion related reaction 579.11 54.53 759 55285 229478 79458866
Hypersensitivity 535.73 54.53 782 55262 261457 79426887
Hip arthroplasty 525.19 54.53 322 55722 35434 79652910
Blister 521.18 54.53 524 55520 118952 79569392
Swollen joint count increased 485.30 54.53 262 55782 22665 79665679
Product use issue 483.47 54.53 663 55381 209159 79479185
Blood cholesterol increased 445.90 54.53 410 55634 83310 79605034
Knee arthroplasty 438.68 54.53 309 55735 42939 79645405
Pain 407.71 54.53 1249 54795 702553 78985791
Type 2 diabetes mellitus 393.46 54.53 324 55720 56798 79631546
Therapeutic product effect decreased 375.99 54.53 517 55527 163346 79524998
Acute kidney injury 320.19 54.53 10 56034 519394 79168950
Injury 307.09 54.53 323 55721 77173 79611171
Death 305.19 54.53 25 56019 566489 79121855
Musculoskeletal stiffness 289.56 54.53 474 55570 174534 79513810
Irritable bowel syndrome 285.91 54.53 281 55763 61960 79626384
Fibromyalgia 283.57 54.53 284 55760 64056 79624288
Toxicity to various agents 280.25 54.53 3 56041 421537 79266807
Liver injury 277.73 54.53 265 55779 56349 79631995
Hypotension 273.02 54.53 8 56036 440309 79248035
Drug interaction 271.37 54.53 4 56040 415179 79273165
Folliculitis 269.34 54.53 258 55786 55122 79633222
Psoriatic arthropathy 260.19 54.53 297 55747 77702 79610642
Rash 259.66 54.53 943 55101 577415 79110929
Condition aggravated 258.69 54.53 856 55188 500268 79188076
Mobility decreased 249.77 54.53 365 55679 121810 79566534
Anaemia 244.14 54.53 18 56026 444997 79243347
General physical health deterioration 239.62 54.53 569 55475 274669 79413675
Muscle injury 239.49 54.53 228 55816 48333 79640011
Adverse event 220.91 54.53 241 55803 59973 79628371
Arthralgia 220.06 54.53 888 55156 570915 79117429
Sleep disorder due to general medical condition, insomnia type 213.82 54.53 204 55840 43352 79644992
Deep vein thrombosis postoperative 203.03 54.53 114 55930 10638 79677706
Prescribed overdose 198.54 54.53 184 55860 37699 79650645
Adverse drug reaction 183.86 54.53 230 55814 66162 79622182
Live birth 176.34 54.53 128 55916 18616 79669728
Lip dry 174.70 54.53 118 55926 15300 79673044
Drug ineffective 174.65 54.53 1325 54719 1079588 78608756
Fall 172.01 54.53 64 55980 487565 79200779
Facet joint syndrome 171.52 54.53 104 55940 11198 79677146
Autoimmune disorder 166.74 54.53 118 55926 16494 79671850
Impaired healing 163.51 54.53 251 55793 87404 79600940
Constipation 162.39 54.53 9 56035 283041 79405303
Retinitis 161.36 54.53 79 55965 5564 79682780
Product use in unapproved indication 157.78 54.53 459 55585 249900 79438444
Intentional product use issue 153.86 54.53 334 55710 151778 79536566
Exposure during pregnancy 152.52 54.53 263 55781 100869 79587475
Adjustment disorder with depressed mood 149.30 54.53 88 55956 8998 79679346
Ill-defined disorder 143.58 54.53 203 55841 65672 79622672
Peripheral venous disease 139.20 54.53 104 55940 15805 79672539
Cough 136.40 54.53 44 56000 366745 79321599
Somnolence 135.83 54.53 8 56036 238973 79449371
Joint range of motion decreased 134.02 54.53 140 55904 33142 79655202
Dislocation of vertebra 131.26 54.53 77 55967 7803 79680541
Thrombocytopenia 128.97 54.53 17 56027 265242 79423102
Osteoarthritis 126.36 54.53 223 55821 87086 79601258
Stomatitis 124.87 54.53 301 55743 146456 79541888
Blood pressure increased 123.47 54.53 6 56038 211354 79476990
Breast cancer stage III 122.93 54.53 80 55964 9746 79678598
Dyspnoea 120.76 54.53 265 55779 856760 78831584
Haemoglobin decreased 118.82 54.53 10 56034 222109 79466235
Seizure 118.49 54.53 3 56041 188831 79499513
Lower limb fracture 118.23 54.53 111 55933 23104 79665240
Sepsis 116.02 54.53 24 56020 269404 79418940
Grip strength decreased 112.21 54.53 105 55939 21764 79666580
Atrial fibrillation 111.31 54.53 7 56037 197879 79490465
Renal failure 107.62 54.53 9 56035 200959 79487385
Hypoaesthesia 102.65 54.53 318 55726 179034 79509310
Respiratory failure 99.98 54.53 7 56037 180904 79507440
Disease progression 99.42 54.53 8 56036 184354 79503990
Joint dislocation 98.00 54.53 87 55957 16852 79671492
Loss of consciousness 97.34 54.53 5 56039 167938 79520406
Myocardial infarction 96.54 54.53 9 56035 184120 79504224
Exostosis 96.37 54.53 86 55958 16772 79671572
Back pain 95.83 54.53 47 55997 304133 79384211
Tremor 95.70 54.53 6 56038 170077 79518267
Bone erosion 94.09 54.53 87 55957 17760 79670584
Lupus-like syndrome 94.07 54.53 78 55966 13779 79674565
C-reactive protein abnormal 89.44 54.53 138 55906 48229 79640115
C-reactive protein 89.16 54.53 51 55993 4928 79683416
Cardiac arrest 88.68 54.53 9 56035 172087 79516257
Sciatica 88.61 54.53 113 55931 33109 79655235
Joint stiffness 87.73 54.53 125 55919 40705 79647639
Hypercholesterolaemia 87.38 54.53 94 55950 23001 79665343
Pneumonia 87.31 54.53 211 55833 660035 79028309
Gastrointestinal haemorrhage 86.88 54.53 4 56040 147715 79540629
Laryngitis 86.14 54.53 79 55965 15960 79672384
Alanine aminotransferase increased 85.08 54.53 8 56036 162562 79525782
Platelet count decreased 84.49 54.53 17 56027 194647 79493697
Anti-cyclic citrullinated peptide antibody 84.07 54.53 52 55992 5800 79682544
Pulmonary embolism 83.40 54.53 11 56033 171643 79516701
Bursitis 83.37 54.53 114 55930 35730 79652614
Diarrhoea 83.36 54.53 328 55716 880161 78808183
Hyperhidrosis 83.30 54.53 6 56038 151486 79536858
Cardiac failure congestive 83.28 54.53 4 56040 142398 79545946
Lower respiratory tract infection 83.28 54.53 239 55805 128981 79559363
Urinary tract infection 81.17 54.53 46 55998 274466 79413878
Neutropenia 81.16 54.53 51 55993 287659 79400685
Aspartate aminotransferase increased 80.74 54.53 4 56040 138637 79549707
Cerebrovascular accident 80.32 54.53 8 56036 155284 79533060
Cardiac failure 80.03 54.53 8 56036 154834 79533510
Contusion 79.80 54.53 258 55786 148518 79539826
Infection 78.32 54.53 357 55687 241355 79446989
Gait inability 78.23 54.53 145 55899 58772 79629572
Overdose 78.06 54.53 17 56027 184189 79504155
Renal impairment 76.92 54.53 10 56034 157773 79530571
Night sweats 76.56 54.53 134 55910 51961 79636383
Hypokalaemia 75.61 54.53 7 56037 144033 79544311
Myalgia 74.97 54.53 19 56025 185622 79502722
Walking aid user 74.94 54.53 60 55984 10088 79678256
Wound infection 74.31 54.53 88 55956 23903 79664441
Oxygen saturation decreased 74.28 54.53 4 56040 129043 79559301
Lupus vulgaris 72.89 54.53 39 56005 3307 79685037
Bradycardia 72.75 54.53 6 56038 135551 79552793
Foot deformity 72.42 54.53 87 55957 23987 79664357
Palpitations 69.65 54.53 5 56039 126605 79561739
Dysphagia 69.63 54.53 4 56040 122132 79566212
Heart rate increased 68.69 54.53 4 56040 120720 79567624
Injection site pruritus 67.71 54.53 113 55931 42170 79646174
Road traffic accident 66.36 54.53 114 55930 43550 79644794
Pleural effusion 64.47 54.53 12 56032 145250 79543094
Chills 63.55 54.53 17 56027 160217 79528127
Loss of personal independence in daily activities 63.45 54.53 187 55857 102393 79585951
Pancytopenia 63.12 54.53 19 56025 165726 79522618
Gastrointestinal disorder 62.89 54.53 209 55835 121996 79566348
Hepatic cirrhosis 62.31 54.53 98 55946 34808 79653536
Chest discomfort 62.14 54.53 11 56033 138033 79550311
Wheezing 61.35 54.53 201 55843 116463 79571881
Weight decreased 61.15 54.53 97 55947 355101 79333243
Deep vein thrombosis 60.56 54.53 7 56037 120912 79567432
Nausea 60.32 54.53 410 55634 956786 78731558
Tachycardia 59.80 54.53 25 56019 177743 79510601
Epistaxis 59.66 54.53 5 56039 111510 79576834
Feeling abnormal 59.27 54.53 19 56025 159180 79529164
Vision blurred 58.78 54.53 4 56040 105894 79582450
Abdominal pain 58.39 54.53 116 55928 389453 79298891
Pyrexia 57.83 54.53 263 55781 678446 79009898
Obesity 57.76 54.53 95 55949 35030 79653314
Cardio-respiratory arrest 57.68 54.53 5 56039 108505 79579839
Injection site reaction 57.27 54.53 122 55922 54663 79633681
Balance disorder 57.09 54.53 3 56041 98854 79589490
X-ray abnormal 55.36 54.53 40 56004 5773 79682571

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AC14 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
FDA MoA N0000190478 Interleukin 6 Receptor Antagonists
FDA EPC N0000190480 Interleukin-6 Receptor Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Bacterial infectious disease contraindication 87628006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Interleukin-6 receptor Membrane receptor ANTIBODY BINDING Kd 11.10 IUPHAR DRUG LABEL

External reference:

IDSource
NU90V55F8I UNII
4036706 VANDF
C3885145 UMLSCUI
CHEMBL2108730 ChEMBL_ID
DB11767 DRUGBANK_ID
D10161 KEGG_DRUG
9476 INN_ID
7999 IUPHAR_LIGAND_ID
257686 MMSL
32766 MMSL
d08592 MMSL
017137 NDDF
735231009 SNOMEDCT_US
763522001 SNOMEDCT_US
1923319 RXNORM
C000592401 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
KEVZARA HUMAN PRESCRIPTION DRUG LABEL 1 0024-5908 INJECTION, SOLUTION 150 mg SUBCUTANEOUS BLA 31 sections
KEVZARA HUMAN PRESCRIPTION DRUG LABEL 1 0024-5908 INJECTION, SOLUTION 150 mg SUBCUTANEOUS BLA 31 sections
KEVZARA HUMAN PRESCRIPTION DRUG LABEL 1 0024-5910 INJECTION, SOLUTION 200 mg SUBCUTANEOUS BLA 31 sections
KEVZARA HUMAN PRESCRIPTION DRUG LABEL 1 0024-5910 INJECTION, SOLUTION 200 mg SUBCUTANEOUS BLA 31 sections
KEVZARA HUMAN PRESCRIPTION DRUG LABEL 1 0024-5920 INJECTION, SOLUTION 150 mg SUBCUTANEOUS BLA 31 sections
KEVZARA HUMAN PRESCRIPTION DRUG LABEL 1 0024-5920 INJECTION, SOLUTION 150 mg SUBCUTANEOUS BLA 31 sections
KEVZARA HUMAN PRESCRIPTION DRUG LABEL 1 0024-5922 INJECTION, SOLUTION 200 mg SUBCUTANEOUS BLA 31 sections
KEVZARA HUMAN PRESCRIPTION DRUG LABEL 1 0024-5922 INJECTION, SOLUTION 200 mg SUBCUTANEOUS BLA 31 sections