basiliximab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
chimeric origin	4940	179045-86-4

Description:

Molecule	Description
Synonyms: basiliximab simulect chRFT5 SDZ-CHI-621	Basiliximab functions as an IL-2 receptor antagonist by binding with high affinity to the alpha chain of the high affinity IL-2 receptor complex and inhibiting IL-2 binding. Basiliximab is specifically targeted against IL-2Ralpha, which is selectively expressed on the surface of activated T-lymphocytes. This specific high affinity binding of basiliximab to IL-2Ralpha competitively inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

basiliximab
simulect
chRFT5
SDZ-CHI-621

Basiliximab functions as an IL-2 receptor antagonist by binding with high affinity to the alpha chain of the high affinity IL-2 receptor complex and inhibiting IL-2 binding. Basiliximab is specifically targeted against IL-2Ralpha, which is selectively expressed on the surface of activated T-lymphocytes. This specific high affinity binding of basiliximab to IL-2Ralpha competitively inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
40	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 9, 1998	EMA
May 12, 1998	FDA	NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Kidney transplant rejection	806.11	29.90	179	10792	4092	63473959
Cytomegalovirus infection	714.16	29.90	226	10745	20726	63457325
Transplant rejection	646.08	29.90	180	10791	10600	63467451
Complications of transplanted kidney	467.81	29.90	104	10867	2382	63475669
Polyomavirus-associated nephropathy	407.13	29.90	88	10883	1760	63476291
Thrombotic microangiopathy	359.75	29.90	114	10857	10447	63467604
Post transplant lymphoproliferative disorder	233.89	29.90	69	10902	4962	63473089
Multiple organ dysfunction syndrome	208.70	29.90	127	10844	56625	63421426
Delayed graft function	207.07	29.90	46	10925	1047	63477004
Cytomegalovirus viraemia	196.53	29.90	62	10909	5587	63472464
Posterior reversible encephalopathy syndrome	179.46	29.90	78	10893	17267	63460784
Immunosuppressant drug level increased	160.83	29.90	48	10923	3590	63474461
Blood creatinine increased	160.67	29.90	128	10843	87716	63390335
Renal impairment	147.34	29.90	122	10849	88233	63389818
Transplant dysfunction	147.02	29.90	48	10923	4824	63473227
Renal tubular necrosis	141.35	29.90	59	10912	11819	63466232
BK virus infection	135.19	29.90	41	10930	3238	63474813
Aspergillus infection	126.77	29.90	49	10922	8044	63470007
Liver transplant rejection	118.97	29.90	31	10940	1404	63476647
Fatigue	117.09	29.90	10	10961	888018	62590033
Hyperammonaemia	116.37	29.90	41	10930	5191	63472860
Nephropathy toxic	112.50	29.90	47	10924	9432	63468619
Escherichia infection	111.53	29.90	51	10920	12703	63465348
Transplant failure	111.20	29.90	30	10941	1555	63476496
Mucormycosis	110.28	29.90	34	10937	2837	63475214
Parvovirus B19 infection	108.53	29.90	24	10947	534	63477517
Focal segmental glomerulosclerosis	94.66	29.90	26	10945	1442	63476609
Leukopenia	87.76	29.90	86	10885	77204	63400847
Atypical haemolytic uraemic syndrome	86.42	29.90	21	10950	714	63477337
Renal transplant failure	85.66	29.90	21	10950	741	63477310
Anuria	84.71	29.90	42	10929	12509	63465542
Enterococcal infection	83.45	29.90	36	10935	7812	63470239
Mycoplasma infection	83.05	29.90	19	10952	495	63477556
Herpes simplex	81.63	29.90	36	10935	8235	63469816
Haemolytic uraemic syndrome	80.96	29.90	26	10945	2477	63475574
Pain	79.29	29.90	16	10955	740612	62737439
Ureteric stenosis	79.18	29.90	19	10952	612	63477439
Diffuse large B-cell lymphoma	78.70	29.90	33	10938	6679	63471372
Klebsiella infection	77.24	29.90	35	10936	8531	63469520
Pancreatitis haemorrhagic	77.06	29.90	18	10953	515	63477536
Chronic allograft nephropathy	76.48	29.90	19	10952	709	63477342
Cerebral aspergillosis	75.76	29.90	17	10954	405	63477646
Lymphocele	74.30	29.90	19	10952	798	63477253
Complications of transplanted lung	71.71	29.90	15	10956	254	63477797
Microsporidia infection	70.23	29.90	15	10956	282	63477769
Arthralgia	68.28	29.90	9	10962	569701	62908350
Pseudomonas infection	68.27	29.90	35	10936	11178	63466873
Glomerulonephritis	67.72	29.90	21	10950	1785	63476266
Scedosporium infection	65.75	29.90	16	10955	547	63477504
Pathogen resistance	63.63	29.90	28	10943	6370	63471681
Kidney fibrosis	62.73	29.90	20	10951	1861	63476190
Product use in unapproved indication	62.02	29.90	111	10860	178969	63299082
Respiratory failure	61.97	29.90	82	10889	101776	63376275
Infectious pleural effusion	61.86	29.90	19	10952	1564	63476487
Human herpesvirus 6 infection	61.31	29.90	22	10949	2935	63475116
Graft complication	60.93	29.90	13	10958	243	63477808
Oedematous pancreatitis	60.21	29.90	15	10956	566	63477485
Disseminated aspergillosis	59.61	29.90	11	10960	93	63477958
Bacteraemia	59.03	29.90	37	10934	17311	63460740
Distributive shock	55.75	29.90	17	10954	1366	63476685
Fall	55.63	29.90	3	10968	392331	63085720
Bronchopulmonary aspergillosis	55.62	29.90	28	10943	8607	63469444
Passenger lymphocyte syndrome	55.49	29.90	10	10961	73	63477978
Ureaplasma infection	53.66	29.90	14	10957	637	63477414
Intestine transplant rejection	53.20	29.90	9	10962	43	63478008
Strongyloidiasis	53.13	29.90	16	10955	1232	63476819
Urinary tract infection	52.92	29.90	131	10840	264553	63213498
Epstein-Barr viraemia	51.99	29.90	15	10956	995	63477056
Oedematous kidney	51.81	29.90	10	10961	110	63477941
Epstein-Barr virus infection	51.55	29.90	26	10945	8024	63470027
Diabetic macroangiopathy	50.78	29.90	10	10961	123	63477928
Renal graft infection	49.47	29.90	11	10960	251	63477800
Acid base balance abnormal	49.18	29.90	11	10960	258	63477793
Shock	48.92	29.90	37	10934	23426	63454625
Haemolytic anaemia	48.66	29.90	27	10944	10098	63467953
Urine output decreased	48.39	29.90	28	10943	11342	63466709
Disseminated tuberculosis	47.18	29.90	18	10953	2849	63475202
Acute respiratory distress syndrome	46.62	29.90	36	10935	23498	63454553
Headache	46.38	29.90	26	10945	633215	62844836
Pericarditis constrictive	45.90	29.90	11	10960	352	63477699
Rash	45.63	29.90	20	10951	560851	62917200
Graft loss	45.61	29.90	11	10960	362	63477689
Urinary fistula	44.47	29.90	7	10964	19	63478032
Dizziness	44.43	29.90	10	10961	429915	63048136
Mastitis bacterial	44.20	29.90	8	10963	60	63477991
Nausea	43.95	29.90	50	10921	854421	62623630
Tubulointerstitial nephritis	42.85	29.90	32	10939	19871	63458180
Polyomavirus viraemia	42.73	29.90	12	10959	722	63477329
Incision site pain	41.47	29.90	13	10958	1145	63476906
Proteinuria	39.48	29.90	30	10941	19115	63458936
Drug hypersensitivity	39.41	29.90	4	10967	310683	63167368
Hypersensitivity	39.21	29.90	3	10968	292682	63185369
Human herpesvirus 8 infection	38.82	29.90	9	10962	249	63477802
Ureteral necrosis	38.74	29.90	7	10964	52	63477999
Ascites	38.34	29.90	41	10930	40687	63437364
Acute kidney injury	38.26	29.90	116	10855	263299	63214752
Biloma	37.85	29.90	7	10964	60	63477991
Oliguria	37.63	29.90	22	10949	9079	63468972
Genital herpes simplex	37.44	29.90	9	10962	292	63477759
Extremity necrosis	37.24	29.90	13	10958	1600	63476451
Diabetes mellitus	37.15	29.90	47	10924	55763	63422288
Aeromonas infection	36.43	29.90	7	10964	75	63477976
Pruritus	36.16	29.90	9	10962	361444	63116607
Pneumocystis jirovecii pneumonia	35.98	29.90	27	10944	16887	63461164
Viraemia	35.83	29.90	12	10959	1304	63476747
Intracranial infection	35.76	29.90	6	10965	27	63478024
Hepatitis B	35.71	29.90	16	10955	3796	63474255
Disseminated intravascular coagulation	35.26	29.90	28	10943	19023	63459028
Anaemia	35.17	29.90	121	10850	293309	63184742
Mycobacterium abscessus infection	34.80	29.90	10	10961	654	63477397
Complications of transplanted liver	34.78	29.90	9	10962	396	63477655
Drug resistance	34.72	29.90	30	10941	22903	63455148
Infective aneurysm	34.70	29.90	9	10962	400	63477651
Nocardiosis	34.66	29.90	13	10958	1963	63476088
Herpes simplex hepatitis	34.50	29.90	9	10962	409	63477642
JC virus infection	34.19	29.90	13	10958	2038	63476013
Rhodococcus infection	33.60	29.90	7	10964	116	63477935
Shock haemorrhagic	33.40	29.90	21	10950	9874	63468177
Renal cortical necrosis	33.22	29.90	7	10964	123	63477928
Encephalitis Japanese B	33.15	29.90	6	10965	45	63478006
Capillaritis	32.70	29.90	7	10964	133	63477918
Death	32.60	29.90	12	10959	374369	63103682
Cytomegalovirus test positive	32.59	29.90	14	10957	3004	63475047
End stage renal disease	32.58	29.90	18	10953	6675	63471376
Dyspnoea	32.54	29.90	40	10931	661273	62816778
Smooth muscle cell neoplasm	32.46	29.90	10	10961	831	63477220
Red blood cells urine positive	32.12	29.90	14	10957	3112	63474939
Abdominal discomfort	32.06	29.90	8	10963	320877	63157174
Pain in extremity	31.73	29.90	9	10962	331477	63146574
Swelling	31.40	29.90	5	10966	275373	63202678
IgA nephropathy	31.21	29.90	9	10962	596	63477455
Immunosuppressant drug level decreased	31.13	29.90	10	10961	953	63477098
Malacoplakia	30.95	29.90	7	10964	173	63477878
Agranulocytosis	30.43	29.90	29	10942	25105	63452946
Adenovirus infection	30.33	29.90	14	10957	3557	63474494
Liver abscess	30.03	29.90	13	10958	2841	63475210

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Kidney transplant rejection	1017.53	19.93	303	18169	7194	34931265
Transplant rejection	652.70	19.93	234	18238	10077	34928382
Cytomegalovirus infection	581.39	19.93	281	18191	25854	34912605
Complications of transplanted kidney	508.52	19.93	159	18313	4450	34934009
Polyomavirus-associated nephropathy	446.70	19.93	138	18334	3706	34934753
Delayed graft function	267.57	19.93	82	18390	2139	34936320
Renal tubular necrosis	236.58	19.93	130	18342	15550	34922909
Mucormycosis	198.69	19.93	85	18387	5857	34932602
Strongyloidiasis	196.04	19.93	68	18404	2643	34935816
Thrombotic microangiopathy	185.19	19.93	97	18375	10533	34927926
Post transplant lymphoproliferative disorder	181.43	19.93	82	18390	6446	34932013
Focal segmental glomerulosclerosis	178.74	19.93	59	18413	1966	34936493
BK virus infection	165.59	19.93	74	18398	5664	34932795
Blood creatinine increased	165.11	19.93	226	18246	94750	34843709
Multiple organ dysfunction syndrome	162.37	19.93	201	18271	76365	34862094
Chronic allograft nephropathy	153.91	19.93	47	18425	1210	34937249
Immunosuppressant drug level increased	152.40	19.93	71	18401	5984	34932475
Parvovirus B19 infection	144.33	19.93	41	18431	814	34937645
Graft versus host disease	141.36	19.93	81	18391	10488	34927971
Incision site pain	140.25	19.93	48	18424	1790	34936669
Nephropathy toxic	125.77	19.93	80	18392	12508	34925951
Cytomegalovirus viraemia	124.28	19.93	66	18406	7364	34931095
Transplant dysfunction	123.13	19.93	48	18424	2601	34935858
Tubulointerstitial nephritis	122.33	19.93	96	18376	20928	34917531
Lymphocyte count decreased	118.23	19.93	97	18375	22525	34915934
Fatigue	116.14	19.93	27	18445	370626	34567833
Epstein-Barr virus infection	114.32	19.93	63	18409	7565	34930894
Death	109.86	19.93	37	18435	398012	34540447
Pneumocystis jirovecii pneumonia	106.12	19.93	86	18386	19624	34918835
Renal transplant failure	100.72	19.93	33	18439	1073	34937386
Kidney fibrosis	98.73	19.93	39	18433	2189	34936270
Liver transplant rejection	97.09	19.93	38	18434	2081	34936378
Aspergillus infection	93.80	19.93	66	18406	12188	34926271
Renal tubular atrophy	90.95	19.93	31	18441	1141	34937318
Fall	90.34	19.93	4	18468	202881	34735578
Complications of transplanted lung	88.45	19.93	21	18451	197	34938262
Renal impairment	86.12	19.93	168	18304	94345	34844114
Neutrophil count increased	84.34	19.93	71	18401	17075	34921384
Leukopenia	83.62	19.93	132	18340	62724	34875735
Dizziness	81.31	19.93	10	18462	218511	34719948
Cytomegalovirus colitis	80.61	19.93	36	18436	2748	34935711
Enterococcal infection	80.38	19.93	54	18418	9252	34929207
Bronchopulmonary aspergillosis	78.98	19.93	64	18408	14595	34923864
Transplant failure	78.20	19.93	38	18434	3515	34934944
Cytomegalovirus test positive	77.91	19.93	39	18433	3847	34934612
Adenovirus infection	77.62	19.93	43	18429	5214	34933245
Candida infection	76.30	19.93	68	18404	17647	34920812
Pseudomonas infection	75.17	19.93	58	18414	12324	34926135
Red blood cells urine positive	74.37	19.93	30	18442	1779	34936680
Human ehrlichiosis	72.66	19.93	20	18452	352	34938107
Klebsiella infection	72.47	19.93	49	18423	8482	34929977
Product use in unapproved indication	71.93	19.93	178	18294	117321	34821138
Nausea	71.44	19.93	46	18426	339862	34598597
Ventricular remodelling	71.03	19.93	15	18457	77	34938382
Glomerulosclerosis	68.44	19.93	23	18449	810	34937649
Pneumonia cytomegaloviral	68.23	19.93	33	18439	3021	34935438
Asthenia	65.43	19.93	24	18448	245227	34693232
Dyspnoea	64.11	19.93	63	18409	376719	34561740
Graft loss	63.25	19.93	22	18450	861	34937598
Protein urine present	61.80	19.93	37	18435	5191	34933268
Hepatitis E	60.48	19.93	27	18445	2059	34936400
Malacoplakia	59.66	19.93	18	18454	444	34938015
Rash	59.06	19.93	22	18450	222730	34715729
Lymphocele	57.50	19.93	23	18449	1334	34937125
Hydronephrosis	57.49	19.93	46	18426	10300	34928159
Blood urea increased	56.80	19.93	75	18397	30289	34908170
Viraemia	56.01	19.93	22	18450	1216	34937243
Skin necrosis	55.48	19.93	36	18436	5817	34932642
Human herpesvirus 8 infection	53.70	19.93	20	18452	955	34937504
Renal tubular injury	53.54	19.93	20	18452	963	34937496
Pain	52.94	19.93	21	18451	204654	34733805
Cryptococcosis	50.63	19.93	25	18447	2394	34936065
Enterobacter infection	50.52	19.93	25	18447	2405	34936054
Haemophagocytic lymphohistiocytosis	50.38	19.93	47	18425	12926	34925533
Arthralgia	49.98	19.93	14	18458	170027	34768432
JC virus infection	49.75	19.93	24	18448	2184	34936275
Graft versus host disease in skin	49.59	19.93	29	18443	3896	34934563
Pruritus	47.06	19.93	9	18463	141972	34796487
Ureteric stenosis	46.61	19.93	19	18453	1157	34937302
Gastrointestinal stromal tumour	46.33	19.93	18	18454	966	34937493
Urine output decreased	46.11	19.93	40	18432	10009	34928450
Respiratory failure	46.09	19.93	144	18328	108428	34830031
Disseminated intravascular coagulation	45.69	19.93	57	18415	21759	34916700
Septic shock	45.14	19.93	110	18362	71724	34866735
Renal tubular disorder	45.10	19.93	29	18443	4614	34933845
Cytomegalovirus infection reactivation	44.91	19.93	30	18442	5088	34933371
Sphincter of Oddi dysfunction	44.42	19.93	11	18461	125	34938334
Schistosomiasis	43.33	19.93	9	18463	42	34938417
Glomerulonephritis	43.06	19.93	21	18451	1957	34936502
Renal haemorrhage	42.69	19.93	19	18453	1438	34937021
Urinary tract infection	41.84	19.93	118	18354	83963	34854496
Proteinuria	41.12	19.93	50	18422	18592	34919867
Scedosporium infection	41.05	19.93	16	18456	866	34937593
Graft versus host disease in gastrointestinal tract	40.79	19.93	25	18447	3658	34934801
Oliguria	39.76	19.93	34	18438	8346	34930113
Drug resistance	39.45	19.93	58	18414	25869	34912590
Intestine transplant rejection	38.94	19.93	8	18464	35	34938424
Hepatitis C	38.91	19.93	36	18436	9794	34928665
Posterior reversible encephalopathy syndrome	38.53	19.93	36	18436	9918	34928541
Headache	38.30	19.93	30	18442	200605	34737854
Systemic candida	38.00	19.93	24	18448	3702	34934757
Abdominal wall abscess	37.10	19.93	13	18459	520	34937939
Renal adenoma	36.39	19.93	7	18465	20	34938439
Nephrosclerosis	36.30	19.93	15	18457	946	34937513
Renal graft infection	36.13	19.93	11	18461	280	34938179
Enterovirus infection	35.93	19.93	15	18457	971	34937488
Urinary fistula	35.74	19.93	9	18463	110	34938349
Tongue necrosis	35.65	19.93	7	18465	23	34938436
Diabetes mellitus	35.18	19.93	77	18395	46796	34891663
Fungaemia	35.18	19.93	20	18452	2548	34935911
Renal artery stenosis	34.77	19.93	19	18453	2242	34936217
Procedural pain	34.73	19.93	25	18447	4781	34933678
Diffuse alveolar damage	34.35	19.93	19	18453	2295	34936164
Nocardiosis	34.29	19.93	23	18449	3928	34934531
Hepatitis A	34.11	19.93	12	18460	486	34937973
Malaise	33.95	19.93	29	18443	185796	34752663
Febrile neutropenia	33.81	19.93	15	18457	136834	34801625
Cerebrovascular accident	33.75	19.93	3	18469	84808	34853651
Mediastinitis	33.72	19.93	13	18459	683	34937776
Insomnia	33.55	19.93	7	18465	103900	34834559
Cytomegalovirus gastritis	33.44	19.93	10	18462	239	34938220
Wound dehiscence	32.95	19.93	21	18451	3290	34935169
Malignant neoplasm progression	32.76	19.93	4	18468	88042	34850417
Hyperammonaemia	32.61	19.93	27	18445	6340	34932119
Depression	32.49	19.93	6	18466	97092	34841367
IgA nephropathy	32.36	19.93	15	18457	1248	34937211
Adenoviral haemorrhagic cystitis	32.32	19.93	11	18461	403	34938056
Back pain	32.28	19.93	12	18460	121777	34816682
Pulmonary mucormycosis	32.24	19.93	13	18459	770	34937689
Fungal skin infection	32.06	19.93	19	18453	2615	34935844
Syncope	32.03	19.93	5	18467	91446	34847013
Lymphopenia	31.54	19.93	41	18431	16294	34922165
Argentine haemorrhagic fever	31.49	19.93	6	18466	16	34938443
Pancreas transplant rejection	31.38	19.93	9	18463	185	34938274
Gait disturbance	31.36	19.93	4	18468	85136	34853323
Pyelonephritis acute	30.83	19.93	17	18455	2042	34936417
Sepsis	30.77	19.93	171	18301	166390	34772069
Acute graft versus host disease in skin	30.77	19.93	24	18448	5177	34933282
Capillaritis	30.57	19.93	8	18464	115	34938344
Cardiac failure congestive	30.45	19.93	4	18468	83266	34855193
Myocardial infarction	30.34	19.93	13	18459	121072	34817387
Nephropathy	30.11	19.93	25	18447	5892	34932567
Arteritis infective	30.05	19.93	6	18466	22	34938437
Restrictive allograft syndrome	29.84	19.93	6	18466	23	34938436
Acute respiratory distress syndrome	29.71	19.93	51	18421	25918	34912541
Disseminated mucormycosis	29.46	19.93	11	18461	529	34937930
Graft complication	29.23	19.93	10	18462	372	34938087
Haemolytic uraemic syndrome	29.17	19.93	17	18455	2269	34936190
Right ventricular diastolic collapse	29.08	19.93	7	18465	70	34938389
American trypanosomiasis	28.88	19.93	9	18463	248	34938211
Intra-abdominal haemorrhage	28.37	19.93	17	18455	2387	34936072
Pancytopenia	28.08	19.93	112	18360	95045	34843414
Acute graft versus host disease	28.06	19.93	25	18447	6478	34931981
Pain in extremity	28.04	19.93	16	18456	126497	34811962
Renal vein thrombosis	27.91	19.93	8	18464	164	34938295
Corynebacterium infection	27.90	19.93	11	18461	614	34937845
Sinusitis aspergillus	27.54	19.93	7	18465	89	34938370
Hepatitis cholestatic	27.46	19.93	27	18445	7920	34930539
Peripheral swelling	27.23	19.93	4	18468	76537	34861922
Hyperuricaemia	27.18	19.93	27	18445	8016	34930443
Escherichia urinary tract infection	26.90	19.93	19	18453	3527	34934932
Cryptosporidiosis infection	26.88	19.93	10	18462	476	34937983
Hyperhidrosis	26.82	19.93	4	18468	75688	34862771
Chest pain	26.74	19.93	17	18455	126745	34811714
Herpes simplex hepatitis	26.72	19.93	7	18465	101	34938358
Transitional cell carcinoma metastatic	26.58	19.93	6	18466	44	34938415
Anuria	26.47	19.93	30	18442	10355	34928104
Hyperglycaemia	26.44	19.93	62	18410	39418	34899041
Distributive shock	26.36	19.93	13	18459	1241	34937218
Renal arteriosclerosis	26.26	19.93	8	18464	204	34938255
Fungal infection	26.21	19.93	37	18435	15898	34922561
Somnolence	26.17	19.93	13	18459	111103	34827356
Glomerulonephropathy	25.83	19.93	8	18464	216	34938243
Diffuse mesangial sclerosis	25.01	19.93	6	18466	59	34938400
Erythema	24.80	19.93	8	18464	88772	34849687
Hyperplasia	24.77	19.93	10	18462	594	34937865
Cerebral aspergillosis	24.73	19.93	13	18459	1419	34937040
Urinary tract infection enterococcal	24.35	19.93	11	18461	862	34937597
Cerebral ventricle collapse	24.32	19.93	6	18466	67	34938392
Post procedural urine leak	24.31	19.93	7	18465	146	34938313
Constipation	24.25	19.93	22	18450	136960	34801499
Optic discs blurred	24.24	19.93	6	18466	68	34938391
Pneumonia cryptococcal	23.98	19.93	11	18461	893	34937566
Acinetobacter infection	23.86	19.93	12	18460	1195	34937264
White blood cell count increased	23.71	19.93	61	18411	41090	34897369
Paraesthesia	23.66	19.93	3	18469	64169	34874290
Central nervous system infection	23.62	19.93	10	18462	670	34937789
Lymphorrhoea	23.56	19.93	6	18466	77	34938382
Pelvic fluid collection	23.46	19.93	7	18465	166	34938293
Graft thrombosis	23.43	19.93	8	18464	296	34938163
Immunosuppressant drug level decreased	23.42	19.93	12	18460	1242	34937217
Aplasia pure red cell	23.39	19.93	22	18450	6110	34932349
Endocarditis bacterial	23.19	19.93	11	18461	964	34937495
Pyelonephritis	23.14	19.93	22	18450	6193	34932266
Cytomegalovirus enterocolitis	22.99	19.93	11	18461	983	34937476
Inappropriate schedule of product administration	22.76	19.93	3	18469	62293	34876166
Human herpesvirus 6 infection	22.72	19.93	14	18458	2067	34936392
Vomiting	22.67	19.93	62	18410	247559	34690900
Stenotrophomonas infection	22.54	19.93	14	18458	2096	34936363
Splenic infection fungal	22.51	19.93	6	18466	93	34938366
Erosive duodenitis	22.47	19.93	13	18459	1711	34936748
Pneumocystis jirovecii infection	22.15	19.93	13	18459	1757	34936702
Joint swelling	21.60	19.93	3	18469	59887	34878572
Cytomegalovirus gastroenteritis	21.59	19.93	7	18465	220	34938239
Infection reactivation	21.42	19.93	12	18460	1486	34936973
Urinoma	21.38	19.93	7	18465	227	34938232
Drug hypersensitivity	21.22	19.93	8	18464	80521	34857938
Peritonitis	21.21	19.93	34	18438	16331	34922128
Splenic necrosis	21.17	19.93	6	18466	118	34938341
Weight decreased	21.17	19.93	38	18434	176263	34762196
Enamel anomaly	21.12	19.93	6	18466	119	34938340
Complications of transplanted liver	21.12	19.93	7	18465	236	34938223
Myalgia	21.11	19.93	9	18463	84101	34854358
Hepatic artery thrombosis	20.98	19.93	7	18465	241	34938218
Pulmonary nocardiosis	20.85	19.93	10	18462	898	34937561
Gonococcal infection	20.77	19.93	5	18467	50	34938409
Bacterial pyelonephritis	20.71	19.93	7	18465	251	34938208
Dengue fever	20.66	19.93	7	18465	253	34938206
Urticaria	20.55	19.93	4	18468	62373	34876086
Graft infection	20.16	19.93	8	18464	454	34938005

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Kidney transplant rejection	1569.67	21.22	416	27393	9830	79706749
Transplant rejection	1208.02	21.22	392	27417	19045	79697534
Cytomegalovirus infection	1143.99	21.22	462	27347	42182	79674397
Complications of transplanted kidney	863.79	21.22	235	27574	6131	79710448
Polyomavirus-associated nephropathy	811.67	21.22	218	27591	5409	79711170
Delayed graft function	478.13	21.22	130	27679	3377	79713202
Thrombotic microangiopathy	463.85	21.22	196	27613	19973	79696606
Post transplant lymphoproliferative disorder	355.05	21.22	138	27671	11326	79705253
Renal tubular necrosis	343.90	21.22	170	27639	24869	79691710
Multiple organ dysfunction syndrome	343.38	21.22	305	27504	119941	79596638
Mucormycosis	335.18	21.22	122	27687	8347	79708232
Immunosuppressant drug level increased	313.01	21.22	118	27691	8909	79707670
BK virus infection	283.36	21.22	109	27700	8695	79707884
Blood creatinine increased	283.09	21.22	308	27501	154749	79561830
Cytomegalovirus viraemia	272.93	21.22	118	27691	12703	79703876
Focal segmental glomerulosclerosis	268.59	21.22	82	27727	3239	79713340
Strongyloidiasis	268.02	21.22	85	27724	3813	79712766
Parvovirus B19 infection	245.09	21.22	64	27745	1416	79715163
Fatigue	219.67	21.22	32	27777	929695	78786884
Renal impairment	216.94	21.22	271	27538	157512	79559067
Transplant dysfunction	216.77	21.22	85	27724	7136	79709443
Nephropathy toxic	215.04	21.22	116	27693	20303	79696276
Aspergillus infection	207.80	21.22	111	27698	19050	79697529
Chronic allograft nephropathy	203.54	21.22	57	27752	1654	79714925
Incision site pain	187.50	21.22	60	27749	2770	79713809
Posterior reversible encephalopathy syndrome	172.71	21.22	110	27699	26171	79690408
Leukopenia	169.53	21.22	206	27603	116307	79600272
Graft versus host disease	165.61	21.22	88	27721	14938	79701641
Liver transplant rejection	155.86	21.22	54	27755	3194	79713385
Fall	155.44	21.22	3	27806	487626	79228953
Enterococcal infection	153.90	21.22	85	27724	15575	79701004
Renal transplant failure	153.83	21.22	47	27762	1860	79714719
Tubulointerstitial nephritis	152.82	21.22	118	27691	38117	79678462
Complications of transplanted lung	152.63	21.22	35	27774	439	79716140
Transplant failure	151.26	21.22	58	27751	4583	79711996
Klebsiella infection	145.42	21.22	82	27727	15638	79700941
Pain	145.04	21.22	34	27775	703768	79012811
Kidney fibrosis	143.86	21.22	52	27757	3483	79713096
Lymphocyte count decreased	142.87	21.22	124	27685	47165	79669414
Arthralgia	141.15	21.22	17	27792	571786	79144793
Pseudomonas infection	136.12	21.22	87	27722	20816	79695763
Pneumocystis jirovecii pneumonia	135.78	21.22	103	27706	32405	79684174
Epstein-Barr virus infection	135.52	21.22	76	27733	14340	79702239
Nausea	132.28	21.22	86	27723	957110	78759469
Product use in unapproved indication	129.62	21.22	276	27533	250083	79466496
Hyperammonaemia	128.01	21.22	67	27742	11026	79705553
Lymphocele	125.32	21.22	39	27770	1642	79714937
Dizziness	121.98	21.22	19	27790	526422	79190157
Bronchopulmonary aspergillosis	121.42	21.22	83	27726	22211	79694368
Neutrophil count increased	120.26	21.22	92	27717	29304	79687275
Renal tubular atrophy	117.43	21.22	38	27771	1818	79714761
Cytomegalovirus colitis	105.88	21.22	45	27764	4640	79711939
Respiratory failure	104.81	21.22	209	27600	180702	79535877
Escherichia infection	102.70	21.22	69	27740	17948	79698631
Ureteric stenosis	102.53	21.22	32	27777	1360	79715219
Headache	101.18	21.22	51	27758	653721	79062858
Scedosporium infection	100.65	21.22	32	27777	1446	79715133
Hydronephrosis	99.86	21.22	67	27742	17387	79699192
Rash	99.08	21.22	39	27770	578319	79138260
Adenovirus infection	97.41	21.22	51	27758	8396	79708183
Red blood cells urine positive	96.91	21.22	43	27766	4920	79711659
Glomerulonephritis	94.61	21.22	38	27771	3395	79713184
Pruritus	94.23	21.22	13	27796	394635	79321944
Dyspnoea	92.33	21.22	98	27711	856927	78859652
Ventricular remodelling	90.47	21.22	18	27791	107	79716472
Candida infection	89.65	21.22	87	27722	38127	79678452
Death	89.42	21.22	43	27766	566471	79150108
Malacoplakia	88.65	21.22	24	27785	612	79715967
Joint swelling	87.29	21.22	3	27806	288643	79427936
Cerebral aspergillosis	86.72	21.22	30	27779	1766	79714813
Anuria	86.60	21.22	66	27743	20897	79695682
Cytomegalovirus test positive	86.45	21.22	42	27767	5905	79710674
Drug resistance	85.97	21.22	89	27720	42124	79674455
Disseminated intravascular coagulation	84.83	21.22	82	27727	35760	79680819
Blood urea increased	83.79	21.22	94	27715	48696	79667883
Protein urine present	83.51	21.22	49	27760	10063	79706516
JC virus infection	83.49	21.22	36	27773	3845	79712734
Renal graft infection	82.53	21.22	22	27787	528	79716051
Haemolytic uraemic syndrome	81.93	21.22	37	27772	4412	79712167
Graft loss	81.13	21.22	25	27784	1018	79715561
Hypersensitivity	78.34	21.22	3	27806	262236	79454343
Pneumonia cytomegaloviral	78.02	21.22	37	27772	4932	79711647
Malaise	77.55	21.22	37	27772	489832	79226747
Renal tubular injury	75.77	21.22	26	27783	1493	79715086
Human herpesvirus 6 infection	75.29	21.22	37	27772	5333	79711246
Glomerulosclerosis	75.20	21.22	24	27785	1098	79715481
Herpes simplex	75.09	21.22	49	27760	12138	79704441
Distributive shock	74.94	21.22	30	27779	2657	79713922
Pathogen resistance	74.80	21.22	52	27757	14290	79702289
Product dose omission issue	73.37	21.22	3	27806	247534	79469045
Human ehrlichiosis	72.89	21.22	20	27789	537	79716042
Proteinuria	72.52	21.22	72	27737	32430	79684149
Urinary fistula	72.24	21.22	14	27795	71	79716508
Enterobacter infection	71.72	21.22	34	27775	4528	79712051
Cytomegalovirus infection reactivation	71.36	21.22	42	27767	8674	79707905
Oliguria	71.03	21.22	53	27756	16256	79700323
Drug hypersensitivity	70.96	21.22	10	27799	298906	79417673
Diabetes mellitus	70.61	21.22	110	27699	78280	79638299
Mycoplasma infection	70.32	21.22	21	27788	768	79715811
Urinary tract infection	69.43	21.22	232	27577	274280	79442299
Human herpesvirus 8 infection	69.21	21.22	23	27786	1197	79715382
Septic shock	68.83	21.22	140	27669	122661	79593918
Acute respiratory distress syndrome	67.43	21.22	80	27729	43987	79672592
Asthenia	66.41	21.22	49	27760	511640	79204939
Sepsis	65.75	21.22	225	27584	269203	79447376
Graft versus host disease in skin	65.31	21.22	35	27774	6038	79710541
Capillaritis	65.29	21.22	16	27793	271	79716308
Pancreatitis haemorrhagic	65.01	21.22	20	27789	810	79715769
Pain in extremity	65.00	21.22	23	27786	364515	79352064
Atypical haemolytic uraemic syndrome	64.76	21.22	21	27788	1011	79715568
Ureaplasma infection	64.41	21.22	21	27788	1029	79715550
Urine output decreased	64.20	21.22	52	27757	17970	79698609
Hepatitis C	63.98	21.22	44	27765	11881	79704698
Viraemia	62.99	21.22	27	27782	2842	79713737
Graft complication	62.72	21.22	19	27790	730	79715849
Polyomavirus viraemia	61.65	21.22	23	27786	1684	79714895
Insomnia	61.09	21.22	7	27802	245163	79471416
Intestine transplant rejection	59.66	21.22	12	27797	76	79716503
Peripheral swelling	59.55	21.22	11	27798	269606	79446973
Oedematous kidney	59.17	21.22	14	27795	203	79716376
Infusion related reaction	58.83	21.22	6	27803	230231	79486348
Diffuse large B-cell lymphoma	58.61	21.22	42	27767	12107	79704472
Passenger lymphocyte syndrome	55.75	21.22	12	27797	110	79716469
Herpes simplex hepatitis	55.12	21.22	16	27793	529	79716050
Systemic candida	54.07	21.22	32	27777	6674	79709905
IgA nephropathy	53.72	21.22	21	27788	1747	79714832
Haemophagocytic lymphohistiocytosis	53.64	21.22	51	27758	21786	79694793
Renal tubular disorder	52.43	21.22	31	27778	6455	79710124
Depression	52.03	21.22	7	27802	216783	79499796
Diffuse alveolar damage	51.02	21.22	25	27784	3579	79713000
Acute graft versus host disease	51.01	21.22	36	27773	10131	79706448
Graft versus host disease in gastrointestinal tract	50.39	21.22	30	27779	6326	79710253
Sinusitis	50.19	21.22	5	27804	195496	79521083
Infectious pleural effusion	50.12	21.22	25	27784	3719	79712860
Microsporidia infection	50.00	21.22	17	27792	949	79715630
Epstein-Barr viraemia	49.23	21.22	21	27788	2184	79714395
Cryptococcosis	48.77	21.22	24	27785	3469	79713110
Renal haemorrhage	48.77	21.22	21	27788	2235	79714344
Nocardiosis	48.16	21.22	28	27781	5651	79710928
Rhodococcus infection	48.11	21.22	13	27796	329	79716250
Drug level increased	47.94	21.22	64	27745	39587	79676992
Abdominal discomfort	47.89	21.22	14	27795	250713	79465866
Pyelonephritis	47.03	21.22	46	27763	20342	79696237
Weight increased	46.92	21.22	19	27790	277367	79439212
Urticaria	46.86	21.22	5	27804	185196	79531383
Gastrointestinal stromal tumour	46.81	21.22	19	27790	1744	79714835
Back pain	46.53	21.22	24	27785	304156	79412423
Hyperuricaemia	46.22	21.22	36	27773	11763	79704816
Mycobacterium abscessus infection	46.10	21.22	17	27792	1205	79715374
Lung transplant rejection	45.86	21.22	18	27791	1513	79715066
Nephropathy	45.45	21.22	33	27776	9705	79706874
Schistosomiasis	45.45	21.22	9	27800	52	79716527
Disseminated tuberculosis	44.68	21.22	24	27785	4159	79712420
Gait disturbance	44.68	21.22	9	27800	207497	79509082
Immunosuppressant drug level decreased	44.46	21.22	19	27790	1985	79714594
Lymphopenia	44.32	21.22	54	27755	30503	79686076
Vomiting	44.16	21.22	105	27704	665723	79050856
Oedematous pancreatitis	43.14	21.22	16	27793	1152	79715427
Bacteraemia	42.81	21.22	55	27754	32769	79683810
Syncope	42.57	21.22	6	27803	179443	79537136
Acid base balance abnormal	42.46	21.22	12	27797	360	79716219
Diabetic macroangiopathy	42.45	21.22	10	27799	142	79716437
Biloma	42.13	21.22	10	27799	147	79716432
Chest pain	42.11	21.22	23	27786	282281	79434298
Nasopharyngitis	41.95	21.22	18	27791	253863	79462716
Infective aneurysm	41.66	21.22	15	27794	993	79715586
Intracranial infection	41.38	21.22	9	27800	87	79716492
Ureteral necrosis	40.58	21.22	9	27800	96	79716483
Hypoaesthesia	40.27	21.22	7	27802	179345	79537234
Graft thrombosis	40.20	21.22	12	27797	438	79716141
Renal artery stenosis	40.08	21.22	21	27788	3461	79713118
Cerebrovascular accident	39.78	21.22	4	27805	155288	79561291
Swelling	39.76	21.22	13	27796	216698	79499881
Nephrosclerosis	39.44	21.22	17	27792	1813	79714766
Mastitis bacterial	38.59	21.22	8	27801	60	79716519
Leiomyosarcoma	38.45	21.22	11	27798	345	79716234
Renal cortical necrosis	38.33	21.22	11	27798	349	79716230
Aplasia pure red cell	37.67	21.22	27	27782	7783	79708796
Pancytopenia	37.43	21.22	135	27674	165610	79550969
Escherichia urinary tract infection	37.25	21.22	34	27775	13791	79702788
Post procedural urine leak	37.15	21.22	9	27800	145	79716434
End stage renal disease	36.79	21.22	32	27777	12188	79704391
Arteritis infective	36.63	21.22	8	27801	79	79716500
Disseminated aspergillosis	36.53	21.22	14	27795	1104	79715475
Sphincter of Oddi dysfunction	36.33	21.22	11	27798	422	79716157
Mediastinitis	36.24	21.22	13	27796	851	79715728
Myalgia	36.11	21.22	10	27799	185631	79530948
Hyperhidrosis	36.08	21.22	5	27804	151487	79565092
Cough	36.02	21.22	45	27764	366744	79349835
Pulmonary mucormycosis	35.97	21.22	14	27795	1151	79715428
Alopecia	35.75	21.22	18	27791	231337	79485242
Renal adenoma	35.57	21.22	7	27802	39	79716540
Abdominal wall abscess	35.53	21.22	14	27795	1189	79715390
Enterovirus infection	35.24	21.22	16	27793	1931	79714648
Abdominal pain upper	35.21	21.22	17	27792	223802	79492777
Glomerulonephropathy	35.10	21.22	10	27799	309	79716270
Shock	34.94	21.22	58	27751	43490	79673089
White blood cell count increased	34.79	21.22	79	27730	74554	79642025
Skin necrosis	34.78	21.22	37	27772	18050	79698529
Tongue necrosis	34.71	21.22	7	27802	45	79716534
Cytomegalovirus enterocolitis	34.45	21.22	15	27794	1640	79714939
Erosive duodenitis	33.96	21.22	16	27793	2101	79714478
Systemic mycosis	33.34	21.22	17	27792	2649	79713930
Renal vein thrombosis	33.33	21.22	11	27798	560	79716019
Renal haematoma	33.20	21.22	12	27797	803	79715776
Kidney rupture	33.00	21.22	9	27800	236	79716343
Inappropriate schedule of product administration	32.81	21.22	4	27805	133624	79582955
Post transplant distal limb syndrome	32.80	21.22	11	27798	589	79715990
Fungal infection	32.69	21.22	55	27754	41693	79674886
Weight decreased	32.41	21.22	46	27763	355152	79361427
Restrictive allograft syndrome	32.33	21.22	6	27803	23	79716556
Fungaemia	32.11	21.22	20	27789	4571	79712008
Pericarditis constrictive	32.07	21.22	11	27798	631	79715948
Bone marrow failure	31.91	21.22	61	27748	51046	79665533
Constipation	31.89	21.22	31	27778	283019	79433560
Donor specific antibody present	31.81	21.22	9	27800	271	79716308
Disease recurrence	31.77	21.22	56	27753	44053	79672526
Condition aggravated	31.63	21.22	81	27728	501043	79215536
Hepatitis A	31.28	21.22	12	27797	949	79715630
Right ventricular diastolic collapse	31.04	21.22	7	27802	81	79716498
Cardiac failure congestive	31.01	21.22	6	27803	142396	79574183
Ureteric dilatation	30.80	21.22	8	27801	173	79716406
Erythema	30.74	21.22	20	27789	223270	79493309
Corynebacterium infection	30.72	21.22	13	27796	1325	79715254
Pancreatitis acute	30.72	21.22	59	27750	49545	79667034
Decreased appetite	30.60	21.22	45	27764	342373	79374206
Pyrexia	30.53	21.22	366	27443	678343	79038236
Disseminated mucormycosis	30.42	21.22	11	27798	737	79715842
Complications of transplant surgery	30.29	21.22	11	27798	746	79715833
Discomfort	30.26	21.22	4	27805	125613	79590966
Adenoviral haemorrhagic cystitis	30.19	21.22	10	27799	515	79716064
Haemolytic anaemia	30.01	21.22	34	27775	17786	79698793
Drug level fluctuating	29.99	21.22	11	27798	768	79715811
Acinetobacter infection	29.85	21.22	16	27793	2761	79713818
Trichodysplasia spinulosa	29.81	21.22	11	27798	781	79715798
American trypanosomiasis	29.68	21.22	9	27800	347	79716232
Renal arteritis	29.66	21.22	5	27804	9	79716570
Hepatitis cholestatic	29.63	21.22	30	27779	13822	79702757
Arterial rupture	29.49	21.22	11	27798	805	79715774
Human herpesvirus 6 infection reactivation	29.30	21.22	10	27799	565	79716014
Acute graft versus host disease in skin	29.20	21.22	23	27786	7635	79708944
Malignant neoplasm progression	29.05	21.22	6	27803	135984	79580595
Transitional cell carcinoma metastatic	28.95	21.22	6	27803	45	79716534
Ascites	28.80	21.22	74	27735	75488	79641091
Acute kidney injury	28.79	21.22	292	27517	519112	79197467
Haemoglobin decreased	28.71	21.22	153	27656	221966	79494613
Glomerulonephritis membranoproliferative	28.51	21.22	10	27799	613	79715966
Paraesthesia	28.33	21.22	13	27796	176310	79540269
Hyperplasia	28.29	21.22	12	27797	1231	79715348
Complications of transplanted liver	28.25	21.22	9	27800	409	79716170
Blood glucose increased	27.97	21.22	96	27713	114879	79601700
Infection reactivation	27.70	21.22	15	27794	2642	79713937
Pleural effusion	27.59	21.22	112	27697	145150	79571429
Myocardial infarction	27.44	21.22	15	27794	184114	79532465
Drug intolerance	27.42	21.22	31	27778	264088	79452491
Intra-abdominal haemorrhage	27.34	21.22	18	27791	4522	79712057
West Nile viral infection	27.29	21.22	11	27798	991	79715588
Urinary tract infection enterococcal	27.29	21.22	16	27793	3279	79713300
Renal necrosis	27.29	21.22	8	27801	274	79716305
Wound	27.28	21.22	4	27805	116175	79600404
Diffuse mesangial sclerosis	26.97	21.22	6	27803	65	79716514
Arthritis	26.87	21.22	4	27805	114876	79601703
Transient acantholytic dermatosis	26.79	21.22	7	27802	155	79716424
Cryptosporidiosis infection	26.79	21.22	10	27799	733	79715846
Encephalitis Japanese B	26.72	21.22	6	27803	68	79716511
Optic discs blurred	26.72	21.22	6	27803	68	79716511
Epstein-Barr virus associated lymphoproliferative disorder	26.26	21.22	16	27793	3516	79713063
Peritonitis	26.15	21.22	40	27769	27996	79688583
Hepatic artery thrombosis	26.12	21.22	8	27801	319	79716260
Pneumonia cryptococcal	25.86	21.22	12	27797	1523	79715056
Lymphocytic infiltration	25.72	21.22	12	27797	1541	79715038
Neutropenia	25.65	21.22	180	27629	287530	79429049
Wound dehiscence	25.56	21.22	20	27789	6575	79710004
Bacterial pyelonephritis	25.53	21.22	9	27800	560	79716019
Anaemia	25.53	21.22	252	27557	444763	79271816
Gastroenteritis norovirus	25.51	21.22	15	27794	3091	79713488
Wheezing	25.23	21.22	5	27804	116659	79599920
Nephrectomy	25.04	21.22	13	27796	2102	79714477
Hypoglycaemia	25.04	21.22	3	27806	101591	79614988
Fungal skin infection	24.91	21.22	19	27790	6017	79710562
Somnolence	24.85	21.22	28	27781	238953	79477626
Ureteric anastomosis complication	24.81	21.22	5	27804	32	79716547
Renal injury	24.69	21.22	30	27779	16897	79699682
Confusional state	24.49	21.22	46	27763	317951	79398628
Coccidioidomycosis	24.44	21.22	11	27798	1301	79715278
Bilirubin conjugated increased	24.11	21.22	18	27791	5521	79711058
Febrile neutropenia	24.09	21.22	27	27782	230972	79485607
Splenic infection fungal	23.99	21.22	6	27803	111	79716468
Blood pressure increased	23.97	21.22	23	27786	211337	79505242
Pneumocystis jirovecii infection	23.83	21.22	14	27795	2880	79713699
General physical health deterioration	23.78	21.22	37	27772	275201	79441378
Herpes simplex viraemia	23.59	21.22	8	27801	443	79716136
Graft infection	23.58	21.22	9	27800	702	79715877
Granuloma	23.52	21.22	21	27788	8276	79708303
Escherichia bacteraemia	23.51	21.22	19	27790	6543	79710036
Cerebral ventricle collapse	23.50	21.22	6	27803	121	79716458
Hepatitis E	23.43	21.22	14	27795	2972	79713607
Blood albumin decreased	23.19	21.22	35	27774	24208	79692371
Sinusitis aspergillus	23.18	21.22	7	27802	266	79716313
Pneumonia bacterial	23.05	21.22	31	27778	19300	79697279
Endocarditis bacterial	22.83	21.22	11	27798	1518	79715061
Dyslipidaemia	22.73	21.22	24	27785	11609	79704970
Encephalopathy	22.65	21.22	63	27746	67334	79649245
Argentine haemorrhagic fever	22.31	21.22	4	27805	12	79716567
Lymphorrhoea	22.20	21.22	6	27803	152	79716427
Renal vessel disorder	22.17	21.22	7	27802	309	79716270
Guillain-Barre syndrome	22.13	21.22	21	27788	8944	79707635
Brain oedema	22.10	21.22	35	27774	25228	79691351
Cytomegalovirus chorioretinitis	22.04	21.22	17	27792	5473	79711106
Ureteric obstruction	22	21.22	13	27796	2703	79713876
Bronchitis	21.99	21.22	9	27800	130635	79585944
Hyperglycaemia	21.94	21.22	64	27745	70271	79646308
Stomatitis	21.80	21.22	12	27797	146745	79569834
Pneumonia fungal	21.68	21.22	23	27786	11187	79705392
Procedural pain	21.62	21.22	33	27776	23051	79693528
Acid fast bacilli infection	21.56	21.22	6	27803	170	79716409
Hepatic cyst infection	21.56	21.22	6	27803	170	79716409
Progressive multifocal leukoencephalopathy	21.52	21.22	31	27778	20569	79696010
Splenic necrosis	21.46	21.22	6	27803	173	79716406
Renal artery perforation	21.41	21.22	4	27805	16	79716563
Pulmonary nocardiosis	21.31	21.22	10	27799	1301	79715278
Gonococcal infection	21.29	21.22	5	27804	70	79716509

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L04AC02	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Interleukin inhibitors
FDA MoA	N0000010279	Interleukin 2 Receptor Antagonists
MeSH PA	D007155	Immunologic Factors
MeSH PA	D007166	Immunosuppressive Agents
FDA MoA	N0000175621	Interleukin 2 Receptor-directed Antibody Interactions
FDA EPC	N0000175622	Interleukin-2 Receptor Blocking Antibody

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Renal transplant rejection	indication	236570004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Interleukin-2 receptor subunit alpha	Membrane receptor	P01589	IL2RA_HUMAN	ANTIBODY BINDING	Kd	10		DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D03058	KEGG_DRUG
4021113	VUID
N0000148568	NUI
4021113	VANDF
CHEMBL1201439	ChEMBL_ID
6879	IUPHAR_LIGAND_ID
DB00074	DRUGBANK_ID
196102	RXNORM
11703	MMSL
4246	MMSL
d04314	MMSL
007552	NDDF
109135008	SNOMEDCT_US
386978004	SNOMEDCT_US
C0676831	UMLSCUI
D000077552	MESH_DESCRIPTOR_UI
7578	INN_ID
9927MT646M	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Simulect	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0331	INJECTION, POWDER, FOR SOLUTION	20 mg	INTRAVENOUS	BLA	24 sections
Simulect	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0331	INJECTION, POWDER, FOR SOLUTION	20 mg	INTRAVENOUS	BLA	24 sections
Simulect	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0331	INJECTION, POWDER, FOR SOLUTION	20 mg	INTRAVENOUS	BLA	24 sections
Simulect	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0393	INJECTION, POWDER, FOR SOLUTION	10 mg	INTRAVENOUS	BLA	24 sections
Simulect	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0393	INJECTION, POWDER, FOR SOLUTION	10 mg	INTRAVENOUS	BLA	24 sections
Simulect	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0393	INJECTION, POWDER, FOR SOLUTION	10 mg	INTRAVENOUS	BLA	24 sections