ixekizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 5083 1143503-69-8

Description:

MoleculeDescription

Synonyms:

  • ixekizumab (genetical recombination)
  • ixekizumab
  • LY2439821
  • taltz
A humanized anti-interleukin 17 monoclonal antibody used for the treatment of PSORIASIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2.90 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
July 4, 2016 PMDA Eli Lilly Japan
Feb. 25, 2016 EMA
March 22, 2016 FDA ELI LILLY AND CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Therapy interrupted 1619.98 21.60 551 19488 49557 90558851
Injection site erythema 640.84 21.60 348 19691 98154 90510254
Injection site swelling 538.06 21.60 263 19776 59576 90548832
Injection site pain 536.90 21.60 382 19657 173317 90435091
Injection site reaction 515.91 21.60 295 19744 91785 90516623
COVID-19 468.61 21.60 348 19691 168495 90439913
Therapy cessation 372.80 21.60 175 19864 36186 90572222
Illness 294.36 21.60 198 19841 81771 90526637
Psoriasis 268.35 21.60 238 19801 147516 90460892
Drug ineffective 264.35 21.60 783 19256 1383515 89224893
Injection site pruritus 210.01 21.60 137 19902 53697 90554711
Injection site urticaria 207.36 21.60 94 19945 17917 90590491
Influenza 174.52 21.60 183 19856 139081 90469327
Injection site warmth 172.35 21.60 82 19957 17433 90590975
Intentional dose omission 168.13 21.60 81 19958 17702 90590706
Ear infection 162.83 21.60 130 19909 69645 90538763
Injection site rash 155.66 21.60 85 19954 24088 90584320
Sinusitis 132.04 21.60 256 19783 342832 90265576
Fungal infection 115.87 21.60 87 19952 42574 90565834
Urinary tract infection 115.05 21.60 226 19813 305406 90303002
Deafness 99.43 21.60 62 19977 22452 90585956
Pharyngitis streptococcal 93.82 21.60 49 19990 12693 90595715
Inappropriate schedule of product administration 87.98 21.60 135 19904 149798 90458610
Nasopharyngitis 84.95 21.60 239 19800 406865 90201543
Injection site mass 80.70 21.60 54 19985 22036 90586372
Chronic disease 77.16 21.60 16 20023 199 90608209
Surgery 74.81 21.60 69 19970 44818 90563590
Tooth infection 70.56 21.60 48 19991 20122 90588286
Infection 70.10 21.60 207 19832 361887 90246521
Incorrect dose administered 65.56 21.60 84 19955 78846 90529562
Product dose omission issue 63.48 21.60 174 19865 291513 90316895
Bronchitis 63.47 21.60 118 19921 152809 90455599
Confusional state 61.04 21.60 7 20032 386198 90222210
Injection site bruising 60.59 21.60 66 19973 52241 90556167
Pruritus 57.97 21.60 255 19784 541270 90067138
Glossodynia 55.75 21.60 4 20035 321775 90286633
Therapy non-responder 54.87 21.60 104 19935 136600 90471808
Kidney infection 53.51 21.60 45 19994 25871 90582537
Inflammatory bowel disease 53.28 21.60 25 20014 5146 90603262
Dyspnoea 50.52 21.60 73 19966 880882 89727526
SARS-CoV-2 test positive 50.02 21.60 31 20008 11097 90597311
Drug interaction 49.17 21.60 3 20036 276450 90331958
Skin burning sensation 48.85 21.60 38 20001 19573 90588835
Blood parathyroid hormone decreased 47.37 21.60 31 20008 12185 90596223
Treatment delayed 46.02 21.60 12 20027 423 90607985
Upper respiratory tract infection 45.88 21.60 93 19946 128225 90480183
Psoriatic arthropathy 45.52 21.60 132 19907 228203 90380205
Acute kidney injury 45.49 21.60 8 20031 320379 90288029
Pericarditis 45.00 21.60 4 20035 270147 90338261
Arthritis 44.83 21.60 108 19931 167207 90441201
Hypotension 44.34 21.60 9 20030 325388 90283020
Wound 44.27 21.60 7 20032 302973 90305435
Treatment failure 43.63 21.60 157 19882 303771 90304637
Granuloma skin 43.62 21.60 28 20011 10652 90597756
Accidental underdose 43.10 21.60 14 20025 1077 90607331
Panniculitis 42.64 21.60 31 20008 14427 90593981
Erythema 42.34 21.60 129 19910 229117 90379291
Meningoradiculitis 42.28 21.60 9 20030 128 90608280
Device malfunction 40.40 21.60 35 20004 20942 90587466
Device defective 39.49 21.60 18 20021 3468 90604940
Oropharyngeal pain 39.43 21.60 82 19957 115105 90493303
Systemic lupus erythematosus 38.37 21.60 16 20023 361880 90246528
Oedema peripheral 37.58 21.60 6 20033 257909 90350499
Viral infection 37.44 21.60 46 19993 41368 90567040
General physical health deterioration 37.17 21.60 16 20023 355099 90253309
Helicobacter infection 36.10 21.60 4 20035 226846 90381562
Neutropenia 35.70 21.60 4 20035 224900 90383508
Rheumatoid nodule 35.54 21.60 32 20007 20134 90588274
Tuberculin test positive 35.29 21.60 17 20022 3708 90604700
Injection related reaction 35.04 21.60 12 20027 1087 90607321
Spinal operation 35.03 21.60 24 20015 10172 90598236
Basal cell carcinoma 35.00 21.60 40 19999 33349 90575059
Enthesopathy 34.37 21.60 23 20016 9381 90599027
Skin necrosis 34.12 21.60 29 20010 16912 90591496
Lower respiratory tract infection 34.00 21.60 7 20032 250652 90357756
Type 2 diabetes mellitus 33.86 21.60 3 20036 203241 90405167
Asthenia 33.82 21.60 41 19998 533710 90074698
Wheezing 33.67 21.60 6 20033 238074 90370334
Localised infection 33.16 21.60 39 20000 33523 90574885
Candida infection 32.70 21.60 39 20000 34018 90574390
Cellulitis 32.40 21.60 66 19973 91271 90517137
Breath sounds abnormal 32.35 21.60 27 20012 15359 90593049
Skin ulcer 32.05 21.60 47 19992 50028 90558380
Oedema 30.71 21.60 4 20035 200291 90408117
Therapeutic product effect decreased 30.59 21.60 132 19907 277439 90330969
Blood cholesterol increased 29.94 21.60 5 20034 208007 90400401
Antibiotic therapy 29.69 21.60 11 20028 1252 90607156
Wrong technique in device usage process 28.13 21.60 17 20022 5818 90602590
Sleep disorder 27.98 21.60 5 20034 198025 90410383
Exposure during pregnancy 27.85 21.60 9 20030 238401 90370007
Injury 27.84 21.60 5 20034 197344 90411064
Injection site cellulitis 27.70 21.60 11 20028 1510 90606898
Infusion related reaction 27.48 21.60 31 20008 416749 90191659
Hypoaesthesia 27.23 21.60 18 20021 314192 90294216
Defaecation urgency 27.07 21.60 17 20022 6225 90602183
Neoplasm malignant 26.47 21.60 35 20004 33845 90574563
Diffuse alopecia 26.40 21.60 10 20029 1210 90607198
Skin disorder 25.76 21.60 36 20003 36670 90571738
Ulcer 25.73 21.60 34 20005 32848 90575560
Appetite disorder 25.62 21.60 19 20020 9114 90599294
Therapeutic product effect incomplete 25.14 21.60 97 19942 193799 90414609
Demyelinating polyneuropathy 25.11 21.60 9 20030 933 90607475
Weight increased 24.50 21.60 34 20005 417893 90190515
Bowel movement irregularity 23.97 21.60 16 20023 6498 90601910
Muscular weakness 23.79 21.60 8 20031 206658 90401750
Fibromyalgia 23.72 21.60 8 20031 206261 90402147
Injection site induration 23.32 21.60 19 20020 10449 90597959
Skin infection 23.26 21.60 24 20015 17840 90590568
Immune system disorder 23.20 21.60 20 20019 11885 90596523
Decreased appetite 22.71 21.60 30 20009 376510 90231898
Liver injury 22.64 21.60 5 20034 170562 90437846
Drug eruption 22.32 21.60 33 20006 35374 90573034
Oral candidiasis 22.29 21.60 33 20006 35422 90572986
Impaired healing 22.28 21.60 12 20027 234187 90374221
Epiploic appendagitis 21.89 21.60 5 20034 100 90608308

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Therapy interrupted 638.95 26.73 230 10196 22020 42588889
Injection site pain 411.12 26.73 224 10202 57574 42553335
Injection site reaction 386.13 26.73 145 10281 15576 42595333
Psoriasis 372.46 26.73 198 10228 48406 42562503
Injection site erythema 330.66 26.73 139 10287 20056 42590853
Injection site swelling 238.83 26.73 105 10321 16868 42594041
Drug ineffective 209.57 26.73 467 9959 629730 41981179
Therapy cessation 204.96 26.73 100 10326 20350 42590559
Nasopharyngitis 177.60 26.73 154 10272 83842 42527067
Device defective 120.87 26.73 35 10391 1653 42609256
COVID-19 118.97 26.73 144 10282 115804 42495105
Ear infection 117.50 26.73 59 10367 12745 42598164
Illness 117.03 26.73 74 10352 24856 42586053
Incorrect dose administered 97.67 26.73 90 10336 52884 42558025
Injection site pruritus 97.19 26.73 47 10379 9358 42601551
Sinusitis 96.35 26.73 85 10341 47207 42563702
Injection site rash 95.64 26.73 40 10386 5672 42605237
Influenza 92.72 26.73 94 10332 62081 42548828
Infection 92.53 26.73 125 10301 111943 42498966
Ejection fraction decreased 89.99 26.73 60 10366 22027 42588882
Psoriatic arthropathy 76.54 26.73 57 10369 24910 42585999
Intentional dose omission 75.43 26.73 39 10387 8947 42601962
Pharyngitis streptococcal 71.01 26.73 29 10397 3871 42607038
Treatment failure 69.42 26.73 81 10345 62543 42548366
Inflammatory bowel disease 66.85 26.73 27 10399 3502 42607407
Injection site urticaria 61.06 26.73 25 10401 3358 42607551
Product dose omission issue 60.36 26.73 123 10303 154242 42456667
Inappropriate schedule of product administration 58.78 26.73 93 10333 95809 42515100
Injection site mass 54.63 26.73 31 10395 8544 42602365
Pruritus 54.24 26.73 133 10293 188638 42422271
Acute kidney injury 53.99 26.73 12 10414 367325 42243584
Carbon dioxide abnormal 53.83 26.73 13 10413 300 42610609
Therapeutic product effect decreased 52.58 26.73 56 10370 39094 42571815
Injection site warmth 52.46 26.73 21 10405 2662 42608247
Device malfunction 51.43 26.73 34 10392 12293 42598616
Onycholysis 51.07 26.73 16 10410 989 42609920
Cellulitis 49.69 26.73 68 10358 61517 42549392
Therapy non-responder 49.34 26.73 63 10363 53296 42557613
Cardiac failure congestive 47.00 26.73 79 10347 85523 42525386
Surgery 46.92 26.73 37 10389 17579 42593330
Hypotension 45.51 26.73 5 10421 257626 42353283
Drug interaction 45.16 26.73 6 10420 266993 42343916
Fungal infection 43.25 26.73 37 10389 19685 42591224
Device delivery system issue 42.41 26.73 14 10412 1023 42609886
Injection site haemorrhage 38.67 26.73 28 10398 11708 42599201
Arthralgia 38.58 26.73 124 10302 205114 42405795
Antibiotic therapy 37.03 26.73 8 10418 110 42610799
Injection site bruising 36.85 26.73 27 10399 11498 42599411
Lipids increased 36.45 26.73 13 10413 1199 42609710
Cutaneous lymphoma 36.32 26.73 8 10418 121 42610788
Dermatitis psoriasiform 35.99 26.73 15 10411 2107 42608802
Tooth infection 35.62 26.73 23 10403 7988 42602921
Intestinal haemorrhage 35.62 26.73 18 10408 3933 42606976
Tonsillar disorder 35.52 26.73 10 10416 426 42610483
Wrong technique in device usage process 35.35 26.73 16 10410 2741 42608168
Thrombocytopenia 32.82 26.73 4 10422 190275 42420634
SARS-CoV-2 test positive 32.57 26.73 22 10404 8238 42602671
Neutropenia 32.49 26.73 5 10421 199426 42411483
Spinal operation 31.67 26.73 17 10409 4203 42606706
Knee operation 29.89 26.73 14 10412 2594 42608315
Dyspnoea 29.68 26.73 39 10387 442582 42168327
Asthenia 29.51 26.73 16 10410 280777 42330132
Anaemia 29.41 26.73 16 10410 280262 42330647
Cholecystectomy 29.34 26.73 15 10411 3359 42607550
Insurance issue 29.27 26.73 16 10410 4100 42606809
Carbon dioxide decreased 29.27 26.73 13 10413 2131 42608778
Decreased appetite 28.95 26.73 6 10420 193131 42417778
Mucosal dryness 28.92 26.73 12 10414 1666 42609243
Drug dose omission by device 28.92 26.73 18 10408 5868 42605041
Eye infection 28.41 26.73 16 10410 4345 42606564
Therapeutic product effect incomplete 28.22 26.73 57 10369 70882 42540027
Bursitis 27.94 26.73 18 10408 6226 42604683
Pancreatic steatosis 27.62 26.73 7 10419 198 42610711
Ear infection fungal 27.31 26.73 5 10421 27 42610882

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Therapy interrupted 2378.77 20.52 727 22470 49095 110517007
COVID-19 563.73 20.52 442 22755 244618 110321484
Injection site erythema 488.95 20.52 282 22915 93894 110472208
Illness 472.26 20.52 263 22934 81908 110484194
Therapy cessation 458.66 20.52 212 22985 44645 110521457
Injection site swelling 439.73 20.52 228 22969 61562 110504540
Injection site pain 417.51 20.52 325 22872 177597 110388505
Injection site reaction 405.33 20.52 245 22952 88825 110477277
Psoriasis 337.55 20.52 260 22937 139733 110426369
Ear infection 278.67 20.52 170 23027 62562 110503540
Intentional dose omission 276.42 20.52 117 23080 19963 110546139
Sinusitis 252.95 20.52 311 22886 296377 110269725
Influenza 230.63 20.52 227 22970 168874 110397228
Nasopharyngitis 220.48 20.52 337 22860 394024 110172078
Injection site pruritus 178.09 20.52 119 23078 51139 110514963
Infection 155.59 20.52 275 22922 361925 110204177
Pharyngitis streptococcal 155.36 20.52 69 23128 13208 110552894
Injection site warmth 146.44 20.52 72 23125 17333 110548769
Injection site urticaria 138.26 20.52 69 23128 17146 110548956
Fungal infection 132.49 20.52 99 23098 50707 110515395
Surgery 124.84 20.52 88 23109 41195 110524907
Drug ineffective 116.46 20.52 625 22572 1519915 109046187
Injection site rash 113.06 20.52 67 23130 23352 110542750
Urinary tract infection 107.00 20.52 221 22976 326061 110240041
Incorrect dose administered 106.95 20.52 120 23077 103521 110462581
Inappropriate schedule of product administration 103.75 20.52 167 23030 203470 110362632
Inflammatory bowel disease 95.71 20.52 41 23156 7193 110558909
Tooth infection 92.96 20.52 58 23139 22158 110543944
Product dose omission issue 88.42 20.52 203 22994 321579 110244523
Bronchitis 87.19 20.52 134 23063 156898 110409204
Psoriatic arthropathy 79.97 20.52 146 23051 196615 110369487
Cellulitis 77.76 20.52 113 23084 125903 110440199
Acute kidney injury 77.56 20.52 19 23178 635411 109930691
Chronic disease 76.85 20.52 16 23181 215 110565887
Drug interaction 76.53 20.52 8 23189 500175 110065927
Deafness 74.01 20.52 54 23143 26655 110539447
Spinal operation 73.70 20.52 39 23158 10933 110555169
SARS-CoV-2 test positive 72.85 20.52 45 23152 16890 110549212
Device malfunction 71.56 20.52 52 23145 25506 110540596
Confusional state 70.42 20.52 8 23189 468672 110097430
Hypotension 69.34 20.52 13 23184 523836 110042266
Antibiotic therapy 65.71 20.52 19 23178 1043 110565059
Device defective 61.81 20.52 25 23172 3797 110562305
Treatment failure 60.32 20.52 160 23037 277074 110289028
Treatment delayed 59.35 20.52 15 23182 492 110565610
Dyspnoea 58.28 20.52 89 23108 1106783 109459319
Upper respiratory tract infection 57.89 20.52 101 23096 131227 110434875
Neutropenia 57.26 20.52 6 23191 374614 110191488
Oropharyngeal pain 55.72 20.52 101 23096 135175 110430927
Injection site mass 55.48 20.52 44 23153 24569 110541533
Kidney infection 53.95 20.52 44 23153 25555 110540547
Therapeutic product effect decreased 53.13 20.52 141 23056 244175 110321927
Arthritis 51.91 20.52 111 23086 167475 110398627
Localised infection 51.65 20.52 54 23143 42994 110523108
Injection site bruising 50.55 20.52 58 23139 51205 110514897
Asthenia 49.62 20.52 43 23154 688956 109877146
Tuberculin test positive 49.22 20.52 21 23176 3647 110562455
Basal cell carcinoma 47.67 20.52 53 23144 45217 110520885
Carbon dioxide abnormal 46.98 20.52 13 23184 608 110565494
Blood parathyroid hormone decreased 46.91 20.52 31 23166 13058 110553044
Pruritus 46.77 20.52 243 22954 581317 109984785
Viral infection 45.59 20.52 56 23141 53083 110513019
Thrombocytopenia 45.41 20.52 9 23188 348876 110217226
Herpes zoster 44.73 20.52 81 23116 108298 110457804
Granuloma skin 43.56 20.52 28 23169 11255 110554847
Skin disorder 43.06 20.52 49 23148 42864 110523238
Injection related reaction 42.54 20.52 15 23182 1563 110564539
General physical health deterioration 42.51 20.52 18 23179 425277 110140825
Panniculitis 42.03 20.52 31 23166 15551 110550551
Rheumatoid nodule 40.92 20.52 34 23163 20262 110545840
Completed suicide 39.40 20.52 3 23194 242378 110323724
Wrong technique in device usage process 39.32 20.52 22 23175 6879 110559223
Manufacturing product shipping issue 38.67 20.52 8 23189 104 110565998
Meningoradiculitis 38.35 20.52 9 23188 215 110565887
Decreased appetite 37.63 20.52 27 23170 475819 110090283
Onycholysis 37.47 20.52 16 23181 2783 110563319
Wheezing 36.73 20.52 5 23192 255225 110310877
Cardiac operation 36.60 20.52 20 23177 5975 110560127
Dermatitis psoriasiform 36.50 20.52 17 23180 3627 110562475
Wrong schedule 36.32 20.52 11 23186 709 110565393
Skin infection 35.90 20.52 33 23164 22476 110543626
Eye infection 34.98 20.52 27 23170 14491 110551611
Oral candidiasis 34.94 20.52 45 23152 44715 110521387
Hospitalisation 34.85 20.52 86 23111 142407 110423695
Disease progression 34.60 20.52 5 23192 244029 110322073
Paraesthesia 34.21 20.52 8 23189 276513 110289589
Therapeutic product effect incomplete 33.30 20.52 113 23084 223692 110342410
Neoplasm malignant 33.25 20.52 40 23157 37103 110528999
Diffuse alopecia 33.25 20.52 12 23185 1338 110564764
Intentional product use issue 33.09 20.52 6 23191 247900 110318202
Oedema peripheral 32.69 20.52 14 23183 328646 110237456
Cholecystectomy 32.57 20.52 23 23174 10786 110555316
Lipids increased 32.23 20.52 13 23184 1960 110564142
Hyponatraemia 31.95 20.52 4 23193 217649 110348453
Hypoaesthesia 31.87 20.52 13 23184 314210 110251892
Enthesopathy 31.81 20.52 24 23173 12454 110553648
Skin necrosis 31.36 20.52 30 23167 21482 110544620
Cutaneous lymphoma 31.21 20.52 8 23189 278 110565824
Oedema 30.48 20.52 4 23193 209972 110356130
Streptococcal infection 30.12 20.52 22 23175 10868 110555234
Product dispensing error 30.12 20.52 26 23171 16319 110549783
Pericarditis 29.91 20.52 5 23192 219109 110346993
Platelet count decreased 29.86 20.52 6 23191 230437 110335665
Anaemia 29.66 20.52 43 23154 547043 110019059
Somnolence 29.06 20.52 13 23184 297436 110268666
Wound 28.57 20.52 7 23190 234430 110331672
Arthralgia 28.15 20.52 268 22929 779364 109786738
Candida infection 28.07 20.52 42 23155 47967 110518135
Malaise 27.86 20.52 238 22959 671581 109894521
Intestinal haemorrhage 27.80 20.52 18 23179 7323 110558779
Hypokalaemia 27.66 20.52 3 23194 182445 110383657
Respiratory tract infection 27.62 20.52 52 23145 71565 110494537
Gastroenteritis viral 26.93 20.52 33 23164 31193 110534909
Product use issue 26.22 20.52 132 23065 311563 110254539
White blood cell count decreased 25.80 20.52 8 23189 229382 110336720
Skin ulcer 25.53 20.52 47 23150 63598 110502504
Nephrolithiasis 25.44 20.52 48 23149 66164 110499938
Appetite disorder 25.37 20.52 19 23178 9750 110556352
Shoulder operation 25.29 20.52 13 23184 3432 110562670
Emergency care 25.21 20.52 10 23187 1443 110564659
Helicobacter infection 25.15 20.52 4 23193 181873 110384229
Furuncle 25.09 20.52 18 23179 8650 110557452
Tonsillar disorder 24.98 20.52 10 23187 1479 110564623
Defaecation urgency 24.94 20.52 18 23179 8729 110557373
Erythema 24.92 20.52 124 23073 291323 110274779
Ovarian operation 24.87 20.52 4 23193 10 110566092
Neck surgery 24.75 20.52 11 23186 2106 110563996
Tinea pedis 24.49 20.52 12 23185 2863 110563239
Needle issue 24.35 20.52 24 23173 17816 110548286
Ulcer 24.19 20.52 37 23160 43079 110523023
Insurance issue 23.97 20.52 19 23178 10593 110555509
Gallbladder operation 23.46 20.52 11 23186 2382 110563720
Therapy non-responder 23.01 20.52 79 23118 157228 110408874
Ear infection fungal 22.84 20.52 6 23191 230 110565872
Appendicectomy 22.57 20.52 12 23185 3395 110562707
Product distribution issue 22.46 20.52 13 23184 4333 110561769
Bowel movement irregularity 22.39 20.52 16 23181 7644 110558458
Breath sounds abnormal 22.15 20.52 27 23170 25377 110540725
Systemic lupus erythematosus 22.03 20.52 13 23184 254325 110311777
Drug tolerance decreased 21.98 20.52 28 23169 27512 110538590
Carbon dioxide decreased 21.46 20.52 13 23184 4711 110561391
Dermatitis exfoliative generalised 21.33 20.52 18 23179 10954 110555148
Actinic keratosis 21.31 20.52 15 23182 6998 110559104
Cystitis 20.73 20.52 44 23153 65992 110500110
Skin candida 20.68 20.52 10 23187 2318 110563784
Neuropathy peripheral 20.61 20.52 6 23191 179271 110386831

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AC13 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
MeSH PA D003879 Dermatologic Agents
FDA MoA N0000191494 Interleukin-17A Antagonists
FDA EPC N0000191495 Interleukin-17A Antagonist
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:67079 anti-inflammatory agent

Related Drugs by ATC class:

L04AC Interleukin inhibitors 18 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriatic arthritis indication 156370009 DOID:9008
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Erythrodermic psoriasis indication 200977004
Non-radiographic axial spondyloarthritis indication 713777005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Interleukin-17A Cytokine ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
BTY153760O UNII
D10071 KEGG_DRUG
4035606 VANDF
C3489764 UMLSCUI
CHEBI:750112 CHEBI
CHEMBL1743034 ChEMBL_ID
DB11569 DRUGBANK_ID
9467 INN_ID
C549079 MESH_SUPPLEMENTAL_RECORD_UI
7541 IUPHAR_LIGAND_ID
1745099 RXNORM
31578 MMSL
d08425 MMSL
016752 NDDF
724037000 SNOMEDCT_US
763603002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TALTZ HUMAN PRESCRIPTION DRUG LABEL 1 0002-1445 INJECTION, SOLUTION 80 mg SUBCUTANEOUS BLA 30 sections
TALTZ HUMAN PRESCRIPTION DRUG LABEL 1 0002-7724 INJECTION, SOLUTION 80 mg SUBCUTANEOUS BLA 30 sections
TALTZ HUMAN PRESCRIPTION DRUG LABEL 1 0002-8900 INJECTION, SOLUTION 20 mg SUBCUTANEOUS BLA 30 sections
TALTZ HUMAN PRESCRIPTION DRUG LABEL 1 0002-8905 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 30 sections