All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

ixekizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
humanized origin	5083	1143503-69-8

Description:

Molecule	Description
Synonyms: ixekizumab (genetical recombination) ixekizumab LY2439821 taltz	A humanized anti-interleukin 17 monoclonal antibody used for the treatment of PSORIASIS. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
2.90	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
July 4, 2016	PMDA	Eli Lilly Japan
Feb. 25, 2016	EMA
March 22, 2016	FDA	ELI LILLY AND CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Therapy interrupted	1619.98	21.60	551	19488	49557	90558851
Injection site erythema	640.84	21.60	348	19691	98154	90510254
Injection site swelling	538.06	21.60	263	19776	59576	90548832
Injection site pain	536.90	21.60	382	19657	173317	90435091
Injection site reaction	515.91	21.60	295	19744	91785	90516623
COVID-19	468.61	21.60	348	19691	168495	90439913
Therapy cessation	372.80	21.60	175	19864	36186	90572222
Illness	294.36	21.60	198	19841	81771	90526637
Psoriasis	268.35	21.60	238	19801	147516	90460892
Drug ineffective	264.35	21.60	783	19256	1383515	89224893
Injection site pruritus	210.01	21.60	137	19902	53697	90554711
Injection site urticaria	207.36	21.60	94	19945	17917	90590491
Influenza	174.52	21.60	183	19856	139081	90469327
Injection site warmth	172.35	21.60	82	19957	17433	90590975
Intentional dose omission	168.13	21.60	81	19958	17702	90590706
Ear infection	162.83	21.60	130	19909	69645	90538763
Injection site rash	155.66	21.60	85	19954	24088	90584320
Sinusitis	132.04	21.60	256	19783	342832	90265576
Fungal infection	115.87	21.60	87	19952	42574	90565834
Urinary tract infection	115.05	21.60	226	19813	305406	90303002
Deafness	99.43	21.60	62	19977	22452	90585956
Pharyngitis streptococcal	93.82	21.60	49	19990	12693	90595715
Inappropriate schedule of product administration	87.98	21.60	135	19904	149798	90458610
Nasopharyngitis	84.95	21.60	239	19800	406865	90201543
Injection site mass	80.70	21.60	54	19985	22036	90586372
Chronic disease	77.16	21.60	16	20023	199	90608209
Surgery	74.81	21.60	69	19970	44818	90563590
Tooth infection	70.56	21.60	48	19991	20122	90588286
Infection	70.10	21.60	207	19832	361887	90246521
Incorrect dose administered	65.56	21.60	84	19955	78846	90529562
Product dose omission issue	63.48	21.60	174	19865	291513	90316895
Bronchitis	63.47	21.60	118	19921	152809	90455599
Confusional state	61.04	21.60	7	20032	386198	90222210
Injection site bruising	60.59	21.60	66	19973	52241	90556167
Pruritus	57.97	21.60	255	19784	541270	90067138
Glossodynia	55.75	21.60	4	20035	321775	90286633
Therapy non-responder	54.87	21.60	104	19935	136600	90471808
Kidney infection	53.51	21.60	45	19994	25871	90582537
Inflammatory bowel disease	53.28	21.60	25	20014	5146	90603262
Dyspnoea	50.52	21.60	73	19966	880882	89727526
SARS-CoV-2 test positive	50.02	21.60	31	20008	11097	90597311
Drug interaction	49.17	21.60	3	20036	276450	90331958
Skin burning sensation	48.85	21.60	38	20001	19573	90588835
Blood parathyroid hormone decreased	47.37	21.60	31	20008	12185	90596223
Treatment delayed	46.02	21.60	12	20027	423	90607985
Upper respiratory tract infection	45.88	21.60	93	19946	128225	90480183
Psoriatic arthropathy	45.52	21.60	132	19907	228203	90380205
Acute kidney injury	45.49	21.60	8	20031	320379	90288029
Pericarditis	45.00	21.60	4	20035	270147	90338261
Arthritis	44.83	21.60	108	19931	167207	90441201
Hypotension	44.34	21.60	9	20030	325388	90283020
Wound	44.27	21.60	7	20032	302973	90305435
Treatment failure	43.63	21.60	157	19882	303771	90304637
Granuloma skin	43.62	21.60	28	20011	10652	90597756
Accidental underdose	43.10	21.60	14	20025	1077	90607331
Panniculitis	42.64	21.60	31	20008	14427	90593981
Erythema	42.34	21.60	129	19910	229117	90379291
Meningoradiculitis	42.28	21.60	9	20030	128	90608280
Device malfunction	40.40	21.60	35	20004	20942	90587466
Device defective	39.49	21.60	18	20021	3468	90604940
Oropharyngeal pain	39.43	21.60	82	19957	115105	90493303
Systemic lupus erythematosus	38.37	21.60	16	20023	361880	90246528
Oedema peripheral	37.58	21.60	6	20033	257909	90350499
Viral infection	37.44	21.60	46	19993	41368	90567040
General physical health deterioration	37.17	21.60	16	20023	355099	90253309
Helicobacter infection	36.10	21.60	4	20035	226846	90381562
Neutropenia	35.70	21.60	4	20035	224900	90383508
Rheumatoid nodule	35.54	21.60	32	20007	20134	90588274
Tuberculin test positive	35.29	21.60	17	20022	3708	90604700
Injection related reaction	35.04	21.60	12	20027	1087	90607321
Spinal operation	35.03	21.60	24	20015	10172	90598236
Basal cell carcinoma	35.00	21.60	40	19999	33349	90575059
Enthesopathy	34.37	21.60	23	20016	9381	90599027
Skin necrosis	34.12	21.60	29	20010	16912	90591496
Lower respiratory tract infection	34.00	21.60	7	20032	250652	90357756
Type 2 diabetes mellitus	33.86	21.60	3	20036	203241	90405167
Asthenia	33.82	21.60	41	19998	533710	90074698
Wheezing	33.67	21.60	6	20033	238074	90370334
Localised infection	33.16	21.60	39	20000	33523	90574885
Candida infection	32.70	21.60	39	20000	34018	90574390
Cellulitis	32.40	21.60	66	19973	91271	90517137
Breath sounds abnormal	32.35	21.60	27	20012	15359	90593049
Skin ulcer	32.05	21.60	47	19992	50028	90558380
Oedema	30.71	21.60	4	20035	200291	90408117
Therapeutic product effect decreased	30.59	21.60	132	19907	277439	90330969
Blood cholesterol increased	29.94	21.60	5	20034	208007	90400401
Antibiotic therapy	29.69	21.60	11	20028	1252	90607156
Wrong technique in device usage process	28.13	21.60	17	20022	5818	90602590
Sleep disorder	27.98	21.60	5	20034	198025	90410383
Exposure during pregnancy	27.85	21.60	9	20030	238401	90370007
Injury	27.84	21.60	5	20034	197344	90411064
Injection site cellulitis	27.70	21.60	11	20028	1510	90606898
Infusion related reaction	27.48	21.60	31	20008	416749	90191659
Hypoaesthesia	27.23	21.60	18	20021	314192	90294216
Defaecation urgency	27.07	21.60	17	20022	6225	90602183
Neoplasm malignant	26.47	21.60	35	20004	33845	90574563
Diffuse alopecia	26.40	21.60	10	20029	1210	90607198
Skin disorder	25.76	21.60	36	20003	36670	90571738
Ulcer	25.73	21.60	34	20005	32848	90575560
Appetite disorder	25.62	21.60	19	20020	9114	90599294
Therapeutic product effect incomplete	25.14	21.60	97	19942	193799	90414609
Demyelinating polyneuropathy	25.11	21.60	9	20030	933	90607475
Weight increased	24.50	21.60	34	20005	417893	90190515
Bowel movement irregularity	23.97	21.60	16	20023	6498	90601910
Muscular weakness	23.79	21.60	8	20031	206658	90401750
Fibromyalgia	23.72	21.60	8	20031	206261	90402147
Injection site induration	23.32	21.60	19	20020	10449	90597959
Skin infection	23.26	21.60	24	20015	17840	90590568
Immune system disorder	23.20	21.60	20	20019	11885	90596523
Decreased appetite	22.71	21.60	30	20009	376510	90231898
Liver injury	22.64	21.60	5	20034	170562	90437846
Drug eruption	22.32	21.60	33	20006	35374	90573034
Oral candidiasis	22.29	21.60	33	20006	35422	90572986
Impaired healing	22.28	21.60	12	20027	234187	90374221
Epiploic appendagitis	21.89	21.60	5	20034	100	90608308

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Therapy interrupted	638.95	26.73	230	10196	22020	42588889
Injection site pain	411.12	26.73	224	10202	57574	42553335
Injection site reaction	386.13	26.73	145	10281	15576	42595333
Psoriasis	372.46	26.73	198	10228	48406	42562503
Injection site erythema	330.66	26.73	139	10287	20056	42590853
Injection site swelling	238.83	26.73	105	10321	16868	42594041
Drug ineffective	209.57	26.73	467	9959	629730	41981179
Therapy cessation	204.96	26.73	100	10326	20350	42590559
Nasopharyngitis	177.60	26.73	154	10272	83842	42527067
Device defective	120.87	26.73	35	10391	1653	42609256
COVID-19	118.97	26.73	144	10282	115804	42495105
Ear infection	117.50	26.73	59	10367	12745	42598164
Illness	117.03	26.73	74	10352	24856	42586053
Incorrect dose administered	97.67	26.73	90	10336	52884	42558025
Injection site pruritus	97.19	26.73	47	10379	9358	42601551
Sinusitis	96.35	26.73	85	10341	47207	42563702
Injection site rash	95.64	26.73	40	10386	5672	42605237
Influenza	92.72	26.73	94	10332	62081	42548828
Infection	92.53	26.73	125	10301	111943	42498966
Ejection fraction decreased	89.99	26.73	60	10366	22027	42588882
Psoriatic arthropathy	76.54	26.73	57	10369	24910	42585999
Intentional dose omission	75.43	26.73	39	10387	8947	42601962
Pharyngitis streptococcal	71.01	26.73	29	10397	3871	42607038
Treatment failure	69.42	26.73	81	10345	62543	42548366
Inflammatory bowel disease	66.85	26.73	27	10399	3502	42607407
Injection site urticaria	61.06	26.73	25	10401	3358	42607551
Product dose omission issue	60.36	26.73	123	10303	154242	42456667
Inappropriate schedule of product administration	58.78	26.73	93	10333	95809	42515100
Injection site mass	54.63	26.73	31	10395	8544	42602365
Pruritus	54.24	26.73	133	10293	188638	42422271
Acute kidney injury	53.99	26.73	12	10414	367325	42243584
Carbon dioxide abnormal	53.83	26.73	13	10413	300	42610609
Therapeutic product effect decreased	52.58	26.73	56	10370	39094	42571815
Injection site warmth	52.46	26.73	21	10405	2662	42608247
Device malfunction	51.43	26.73	34	10392	12293	42598616
Onycholysis	51.07	26.73	16	10410	989	42609920
Cellulitis	49.69	26.73	68	10358	61517	42549392
Therapy non-responder	49.34	26.73	63	10363	53296	42557613
Cardiac failure congestive	47.00	26.73	79	10347	85523	42525386
Surgery	46.92	26.73	37	10389	17579	42593330
Hypotension	45.51	26.73	5	10421	257626	42353283
Drug interaction	45.16	26.73	6	10420	266993	42343916
Fungal infection	43.25	26.73	37	10389	19685	42591224
Device delivery system issue	42.41	26.73	14	10412	1023	42609886
Injection site haemorrhage	38.67	26.73	28	10398	11708	42599201
Arthralgia	38.58	26.73	124	10302	205114	42405795
Antibiotic therapy	37.03	26.73	8	10418	110	42610799
Injection site bruising	36.85	26.73	27	10399	11498	42599411
Lipids increased	36.45	26.73	13	10413	1199	42609710
Cutaneous lymphoma	36.32	26.73	8	10418	121	42610788
Dermatitis psoriasiform	35.99	26.73	15	10411	2107	42608802
Tooth infection	35.62	26.73	23	10403	7988	42602921
Intestinal haemorrhage	35.62	26.73	18	10408	3933	42606976
Tonsillar disorder	35.52	26.73	10	10416	426	42610483
Wrong technique in device usage process	35.35	26.73	16	10410	2741	42608168
Thrombocytopenia	32.82	26.73	4	10422	190275	42420634
SARS-CoV-2 test positive	32.57	26.73	22	10404	8238	42602671
Neutropenia	32.49	26.73	5	10421	199426	42411483
Spinal operation	31.67	26.73	17	10409	4203	42606706
Knee operation	29.89	26.73	14	10412	2594	42608315
Dyspnoea	29.68	26.73	39	10387	442582	42168327
Asthenia	29.51	26.73	16	10410	280777	42330132
Anaemia	29.41	26.73	16	10410	280262	42330647
Cholecystectomy	29.34	26.73	15	10411	3359	42607550
Insurance issue	29.27	26.73	16	10410	4100	42606809
Carbon dioxide decreased	29.27	26.73	13	10413	2131	42608778
Decreased appetite	28.95	26.73	6	10420	193131	42417778
Mucosal dryness	28.92	26.73	12	10414	1666	42609243
Drug dose omission by device	28.92	26.73	18	10408	5868	42605041
Eye infection	28.41	26.73	16	10410	4345	42606564
Therapeutic product effect incomplete	28.22	26.73	57	10369	70882	42540027
Bursitis	27.94	26.73	18	10408	6226	42604683
Pancreatic steatosis	27.62	26.73	7	10419	198	42610711
Ear infection fungal	27.31	26.73	5	10421	27	42610882

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Therapy interrupted	2378.77	20.52	727	22470	49095	110517007
COVID-19	563.73	20.52	442	22755	244618	110321484
Injection site erythema	488.95	20.52	282	22915	93894	110472208
Illness	472.26	20.52	263	22934	81908	110484194
Therapy cessation	458.66	20.52	212	22985	44645	110521457
Injection site swelling	439.73	20.52	228	22969	61562	110504540
Injection site pain	417.51	20.52	325	22872	177597	110388505
Injection site reaction	405.33	20.52	245	22952	88825	110477277
Psoriasis	337.55	20.52	260	22937	139733	110426369
Ear infection	278.67	20.52	170	23027	62562	110503540
Intentional dose omission	276.42	20.52	117	23080	19963	110546139
Sinusitis	252.95	20.52	311	22886	296377	110269725
Influenza	230.63	20.52	227	22970	168874	110397228
Nasopharyngitis	220.48	20.52	337	22860	394024	110172078
Injection site pruritus	178.09	20.52	119	23078	51139	110514963
Infection	155.59	20.52	275	22922	361925	110204177
Pharyngitis streptococcal	155.36	20.52	69	23128	13208	110552894
Injection site warmth	146.44	20.52	72	23125	17333	110548769
Injection site urticaria	138.26	20.52	69	23128	17146	110548956
Fungal infection	132.49	20.52	99	23098	50707	110515395
Surgery	124.84	20.52	88	23109	41195	110524907
Drug ineffective	116.46	20.52	625	22572	1519915	109046187
Injection site rash	113.06	20.52	67	23130	23352	110542750
Urinary tract infection	107.00	20.52	221	22976	326061	110240041
Incorrect dose administered	106.95	20.52	120	23077	103521	110462581
Inappropriate schedule of product administration	103.75	20.52	167	23030	203470	110362632
Inflammatory bowel disease	95.71	20.52	41	23156	7193	110558909
Tooth infection	92.96	20.52	58	23139	22158	110543944
Product dose omission issue	88.42	20.52	203	22994	321579	110244523
Bronchitis	87.19	20.52	134	23063	156898	110409204
Psoriatic arthropathy	79.97	20.52	146	23051	196615	110369487
Cellulitis	77.76	20.52	113	23084	125903	110440199
Acute kidney injury	77.56	20.52	19	23178	635411	109930691
Chronic disease	76.85	20.52	16	23181	215	110565887
Drug interaction	76.53	20.52	8	23189	500175	110065927
Deafness	74.01	20.52	54	23143	26655	110539447
Spinal operation	73.70	20.52	39	23158	10933	110555169
SARS-CoV-2 test positive	72.85	20.52	45	23152	16890	110549212
Device malfunction	71.56	20.52	52	23145	25506	110540596
Confusional state	70.42	20.52	8	23189	468672	110097430
Hypotension	69.34	20.52	13	23184	523836	110042266
Antibiotic therapy	65.71	20.52	19	23178	1043	110565059
Device defective	61.81	20.52	25	23172	3797	110562305
Treatment failure	60.32	20.52	160	23037	277074	110289028
Treatment delayed	59.35	20.52	15	23182	492	110565610
Dyspnoea	58.28	20.52	89	23108	1106783	109459319
Upper respiratory tract infection	57.89	20.52	101	23096	131227	110434875
Neutropenia	57.26	20.52	6	23191	374614	110191488
Oropharyngeal pain	55.72	20.52	101	23096	135175	110430927
Injection site mass	55.48	20.52	44	23153	24569	110541533
Kidney infection	53.95	20.52	44	23153	25555	110540547
Therapeutic product effect decreased	53.13	20.52	141	23056	244175	110321927
Arthritis	51.91	20.52	111	23086	167475	110398627
Localised infection	51.65	20.52	54	23143	42994	110523108
Injection site bruising	50.55	20.52	58	23139	51205	110514897
Asthenia	49.62	20.52	43	23154	688956	109877146
Tuberculin test positive	49.22	20.52	21	23176	3647	110562455
Basal cell carcinoma	47.67	20.52	53	23144	45217	110520885
Carbon dioxide abnormal	46.98	20.52	13	23184	608	110565494
Blood parathyroid hormone decreased	46.91	20.52	31	23166	13058	110553044
Pruritus	46.77	20.52	243	22954	581317	109984785
Viral infection	45.59	20.52	56	23141	53083	110513019
Thrombocytopenia	45.41	20.52	9	23188	348876	110217226
Herpes zoster	44.73	20.52	81	23116	108298	110457804
Granuloma skin	43.56	20.52	28	23169	11255	110554847
Skin disorder	43.06	20.52	49	23148	42864	110523238
Injection related reaction	42.54	20.52	15	23182	1563	110564539
General physical health deterioration	42.51	20.52	18	23179	425277	110140825
Panniculitis	42.03	20.52	31	23166	15551	110550551
Rheumatoid nodule	40.92	20.52	34	23163	20262	110545840
Completed suicide	39.40	20.52	3	23194	242378	110323724
Wrong technique in device usage process	39.32	20.52	22	23175	6879	110559223
Manufacturing product shipping issue	38.67	20.52	8	23189	104	110565998
Meningoradiculitis	38.35	20.52	9	23188	215	110565887
Decreased appetite	37.63	20.52	27	23170	475819	110090283
Onycholysis	37.47	20.52	16	23181	2783	110563319
Wheezing	36.73	20.52	5	23192	255225	110310877
Cardiac operation	36.60	20.52	20	23177	5975	110560127
Dermatitis psoriasiform	36.50	20.52	17	23180	3627	110562475
Wrong schedule	36.32	20.52	11	23186	709	110565393
Skin infection	35.90	20.52	33	23164	22476	110543626
Eye infection	34.98	20.52	27	23170	14491	110551611
Oral candidiasis	34.94	20.52	45	23152	44715	110521387
Hospitalisation	34.85	20.52	86	23111	142407	110423695
Disease progression	34.60	20.52	5	23192	244029	110322073
Paraesthesia	34.21	20.52	8	23189	276513	110289589
Therapeutic product effect incomplete	33.30	20.52	113	23084	223692	110342410
Neoplasm malignant	33.25	20.52	40	23157	37103	110528999
Diffuse alopecia	33.25	20.52	12	23185	1338	110564764
Intentional product use issue	33.09	20.52	6	23191	247900	110318202
Oedema peripheral	32.69	20.52	14	23183	328646	110237456
Cholecystectomy	32.57	20.52	23	23174	10786	110555316
Lipids increased	32.23	20.52	13	23184	1960	110564142
Hyponatraemia	31.95	20.52	4	23193	217649	110348453
Hypoaesthesia	31.87	20.52	13	23184	314210	110251892
Enthesopathy	31.81	20.52	24	23173	12454	110553648
Skin necrosis	31.36	20.52	30	23167	21482	110544620
Cutaneous lymphoma	31.21	20.52	8	23189	278	110565824
Oedema	30.48	20.52	4	23193	209972	110356130
Streptococcal infection	30.12	20.52	22	23175	10868	110555234
Product dispensing error	30.12	20.52	26	23171	16319	110549783
Pericarditis	29.91	20.52	5	23192	219109	110346993
Platelet count decreased	29.86	20.52	6	23191	230437	110335665
Anaemia	29.66	20.52	43	23154	547043	110019059
Somnolence	29.06	20.52	13	23184	297436	110268666
Wound	28.57	20.52	7	23190	234430	110331672
Arthralgia	28.15	20.52	268	22929	779364	109786738
Candida infection	28.07	20.52	42	23155	47967	110518135
Malaise	27.86	20.52	238	22959	671581	109894521
Intestinal haemorrhage	27.80	20.52	18	23179	7323	110558779
Hypokalaemia	27.66	20.52	3	23194	182445	110383657
Respiratory tract infection	27.62	20.52	52	23145	71565	110494537
Gastroenteritis viral	26.93	20.52	33	23164	31193	110534909
Product use issue	26.22	20.52	132	23065	311563	110254539
White blood cell count decreased	25.80	20.52	8	23189	229382	110336720
Skin ulcer	25.53	20.52	47	23150	63598	110502504
Nephrolithiasis	25.44	20.52	48	23149	66164	110499938
Appetite disorder	25.37	20.52	19	23178	9750	110556352
Shoulder operation	25.29	20.52	13	23184	3432	110562670
Emergency care	25.21	20.52	10	23187	1443	110564659
Helicobacter infection	25.15	20.52	4	23193	181873	110384229
Furuncle	25.09	20.52	18	23179	8650	110557452
Tonsillar disorder	24.98	20.52	10	23187	1479	110564623
Defaecation urgency	24.94	20.52	18	23179	8729	110557373
Erythema	24.92	20.52	124	23073	291323	110274779
Ovarian operation	24.87	20.52	4	23193	10	110566092
Neck surgery	24.75	20.52	11	23186	2106	110563996
Tinea pedis	24.49	20.52	12	23185	2863	110563239
Needle issue	24.35	20.52	24	23173	17816	110548286
Ulcer	24.19	20.52	37	23160	43079	110523023
Insurance issue	23.97	20.52	19	23178	10593	110555509
Gallbladder operation	23.46	20.52	11	23186	2382	110563720
Therapy non-responder	23.01	20.52	79	23118	157228	110408874
Ear infection fungal	22.84	20.52	6	23191	230	110565872
Appendicectomy	22.57	20.52	12	23185	3395	110562707
Product distribution issue	22.46	20.52	13	23184	4333	110561769
Bowel movement irregularity	22.39	20.52	16	23181	7644	110558458
Breath sounds abnormal	22.15	20.52	27	23170	25377	110540725
Systemic lupus erythematosus	22.03	20.52	13	23184	254325	110311777
Drug tolerance decreased	21.98	20.52	28	23169	27512	110538590
Carbon dioxide decreased	21.46	20.52	13	23184	4711	110561391
Dermatitis exfoliative generalised	21.33	20.52	18	23179	10954	110555148
Actinic keratosis	21.31	20.52	15	23182	6998	110559104
Cystitis	20.73	20.52	44	23153	65992	110500110
Skin candida	20.68	20.52	10	23187	2318	110563784
Neuropathy peripheral	20.61	20.52	6	23191	179271	110386831

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L04AC13	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Interleukin inhibitors
MeSH PA	D003879	Dermatologic Agents
FDA MoA	N0000191494	Interleukin-17A Antagonists
FDA EPC	N0000191495	Interleukin-17A Antagonist
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35469	antidepressant
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35842	antirheumatic drug
CHEBI has role	CHEBI:50748	antipsoriatic
CHEBI has role	CHEBI:67079	anti-inflammatory agent

Related Drugs by ATC class:

L04AC Interleukin inhibitors 18 drugs

anakinrabasiliximabbimekizumabbrodalumabcanakinumabdaclizumabguselkumabmirikizumabrilonaceptrisankizumabsarilumabsatralizumab show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ankylosing spondylitis	indication	9631008	DOID:7147
Psoriatic arthritis	indication	156370009	DOID:9008
Plaque psoriasis	indication	200965009
Pustular psoriasis	indication	200973000
Erythrodermic psoriasis	indication	200977004
Non-radiographic axial spondyloarthritis	indication	713777005

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Interleukin-17A	Cytokine	Q16552	IL17_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
BTY153760O	UNII
D10071	KEGG_DRUG
4035606	VANDF
C3489764	UMLSCUI
CHEBI:750112	CHEBI
CHEMBL1743034	ChEMBL_ID
DB11569	DRUGBANK_ID
9467	INN_ID
C549079	MESH_SUPPLEMENTAL_RECORD_UI
7541	IUPHAR_LIGAND_ID
1745099	RXNORM
31578	MMSL
d08425	MMSL
016752	NDDF
724037000	SNOMEDCT_US
763603002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
TALTZ	HUMAN PRESCRIPTION DRUG LABEL	1	0002-1445	INJECTION, SOLUTION	80 mg	SUBCUTANEOUS	BLA	30 sections
TALTZ	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7724	INJECTION, SOLUTION	80 mg	SUBCUTANEOUS	BLA	30 sections
TALTZ	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8900	INJECTION, SOLUTION	20 mg	SUBCUTANEOUS	BLA	30 sections
TALTZ	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8905	INJECTION, SOLUTION	40 mg	SUBCUTANEOUS	BLA	30 sections