Stem definition | Drug id | CAS RN |
---|---|---|
human origin | 4953 | 152923-56-3 |
Molecule | Description |
---|---|
Synonyms:
|
An anti-TAC (INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT) humanized monoclonal antibody (immunoglobulin G1 disulfide with human-mouse monoclonal clone 1H4 light chain, dimer) that is used in the treatment of ACUTE RELAPSING MULTIPLE SCLEROSIS.
|
Dose | Unit | Route |
---|---|---|
5 | mg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 26, 1999 | EMA | ||
Dec. 10, 1997 | FDA | HOFFMAN-LA ROCHE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Transplant dysfunction | 2399.88 | 47.75 | 405 | 4522 | 4341 | 56282799 |
Transplant rejection | 1921.64 | 47.75 | 376 | 4551 | 9558 | 56277582 |
Ovarian cyst | 1701.74 | 47.75 | 364 | 4563 | 14502 | 56272638 |
Acne | 1590.24 | 47.75 | 367 | 4560 | 20769 | 56266371 |
Alopecia | 789.86 | 47.75 | 418 | 4509 | 293040 | 55994100 |
Liver function test abnormal | 403.59 | 47.75 | 151 | 4776 | 45520 | 56241620 |
Sleep disorder due to general medical condition, insomnia type | 385.48 | 47.75 | 144 | 4783 | 43194 | 56243946 |
Multiple sclerosis relapse | 268.31 | 47.75 | 112 | 4815 | 44791 | 56242349 |
Pneumonia | 141.16 | 47.75 | 175 | 4752 | 406923 | 55880217 |
Condition aggravated | 128.71 | 47.75 | 154 | 4773 | 344744 | 55942396 |
Loss of personal independence in daily activities | 116.33 | 47.75 | 78 | 4849 | 81291 | 56205849 |
Rheumatoid arthritis | 114.41 | 47.75 | 153 | 4774 | 382451 | 55904689 |
Incorrect route of product administration | 93.93 | 47.75 | 43 | 4884 | 21286 | 56265854 |
Overdose | 93.68 | 47.75 | 76 | 4851 | 105754 | 56181386 |
Kidney transplant rejection | 85.09 | 47.75 | 26 | 4901 | 4187 | 56282953 |
Pain | 75.34 | 47.75 | 173 | 4754 | 663011 | 55624129 |
Product use issue | 59.29 | 47.75 | 77 | 4850 | 185964 | 56101176 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple sclerosis relapse | 149.70 | 37.74 | 36 | 530 | 12011 | 31684767 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Transplant dysfunction | 2350.11 | 45.90 | 408 | 4658 | 6501 | 70916877 |
Ovarian cyst | 1866.01 | 45.90 | 365 | 4701 | 11407 | 70911971 |
Transplant rejection | 1753.79 | 45.90 | 373 | 4693 | 17798 | 70905580 |
Acne | 1602.94 | 45.90 | 367 | 4699 | 24622 | 70898756 |
Alopecia | 1020.29 | 45.90 | 416 | 4650 | 198074 | 70725304 |
Sleep disorder due to general medical condition, insomnia type | 441.28 | 45.90 | 144 | 4922 | 35588 | 70887790 |
Liver function test abnormal | 394.10 | 45.90 | 152 | 4914 | 60994 | 70862384 |
Multiple sclerosis relapse | 305.90 | 45.90 | 115 | 4951 | 42902 | 70880476 |
Rheumatoid arthritis | 172.57 | 45.90 | 152 | 4914 | 291653 | 70631725 |
Condition aggravated | 132.17 | 45.90 | 157 | 4909 | 427478 | 70495900 |
Loss of personal independence in daily activities | 127.81 | 45.90 | 78 | 4988 | 84832 | 70838546 |
Pneumonia | 121.02 | 45.90 | 178 | 4888 | 596054 | 70327324 |
Pain | 101.41 | 45.90 | 169 | 4897 | 628647 | 70294731 |
Incorrect route of product administration | 93.37 | 45.90 | 43 | 5023 | 26449 | 70896929 |
Overdose | 83.53 | 45.90 | 80 | 4986 | 169665 | 70753713 |
Product use issue | 79.58 | 45.90 | 80 | 4986 | 179857 | 70743521 |
Drug ineffective | 60.99 | 45.90 | 175 | 4891 | 939577 | 69983801 |
Encephalitis autoimmune | 48.96 | 45.90 | 14 | 5052 | 2197 | 70921181 |
None
Source | Code | Description |
---|---|---|
ATC | L04AC01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Interleukin inhibitors |
FDA MoA | N0000010279 | Interleukin 2 Receptor Antagonists |
MeSH PA | D007155 | Immunologic Factors |
MeSH PA | D007166 | Immunosuppressive Agents |
FDA MoA | N0000175621 | Interleukin 2 Receptor-directed Antibody Interactions |
FDA EPC | N0000175622 | Interleukin-2 Receptor Blocking Antibody |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Renal transplant rejection | indication | 236570004 | |
Relapsing remitting multiple sclerosis | indication | 426373005 | DOID:2378 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Interleukin-2 receptor | Membrane receptor | ANTIBODY BINDING | Kd | 8 | IUPHAR | DRUG LABEL |
ID | Source |
---|---|
D03639 | KEGG_DRUG |
4021083 | VUID |
N0000148541 | NUI |
4021083 | VANDF |
CHEMBL1201605 | ChEMBL_ID |
6880 | IUPHAR_LIGAND_ID |
DB00111 | DRUGBANK_ID |
CUJ2MVI71Y | UNII |
1795335 | RXNORM |
11508 | MMSL |
241453 | MMSL |
4529 | MMSL |
d04262 | MMSL |
007284 | NDDF |
109133001 | SNOMEDCT_US |
386977009 | SNOMEDCT_US |
C0663182 | UMLSCUI |
D000077561 | MESH_DESCRIPTOR_UI |
7164 | INN_ID |
None