Stem definition | Drug id | CAS RN |
---|---|---|
human origin | 4953 | 152923-56-3 |
Molecule | Description |
---|---|
Synonyms:
|
An anti-TAC (INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT) humanized monoclonal antibody (immunoglobulin G1 disulfide with human-mouse monoclonal clone 1H4 light chain, dimer) that is used in the treatment of ACUTE RELAPSING MULTIPLE SCLEROSIS.
|
Dose | Unit | Route |
---|---|---|
5 | mg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 26, 1999 | EMA | ||
Dec. 10, 1997 | FDA | HOFFMAN-LA ROCHE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Transplant dysfunction | 2367.98 | 49.14 | 405 | 4454 | 4279 | 50595986 |
Transplant rejection | 1899.59 | 49.14 | 376 | 4483 | 9233 | 50591032 |
Ovarian cyst | 1690.22 | 49.14 | 364 | 4495 | 13632 | 50586633 |
Acne | 1584.27 | 49.14 | 367 | 4492 | 19228 | 50581037 |
Alopecia | 824.77 | 49.14 | 418 | 4441 | 244629 | 50355636 |
Sleep disorder due to general medical condition, insomnia type | 417.61 | 49.14 | 144 | 4715 | 31303 | 50568962 |
Liver function test abnormal | 394.36 | 49.14 | 151 | 4708 | 44188 | 50556077 |
Multiple sclerosis relapse | 259.77 | 49.14 | 111 | 4748 | 42853 | 50557412 |
Rheumatoid arthritis | 183.90 | 49.14 | 153 | 4706 | 202397 | 50397868 |
Pneumonia | 138.46 | 49.14 | 175 | 4684 | 378226 | 50222039 |
Condition aggravated | 134.14 | 49.14 | 153 | 4706 | 296905 | 50303360 |
Loss of personal independence in daily activities | 120.41 | 49.14 | 78 | 4781 | 69972 | 50530293 |
Incorrect route of product administration | 95.61 | 49.14 | 43 | 4816 | 18623 | 50581642 |
Overdose | 91.47 | 49.14 | 76 | 4783 | 99651 | 50500614 |
Kidney transplant rejection | 84.13 | 49.14 | 26 | 4833 | 3961 | 50596304 |
Pain | 79.30 | 49.14 | 172 | 4687 | 578731 | 50021534 |
Product use issue | 67.11 | 49.14 | 77 | 4782 | 149398 | 50450867 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple sclerosis relapse | 149.72 | 36.32 | 36 | 521 | 11383 | 29562587 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Transplant dysfunction | 2330.09 | 49.09 | 408 | 4579 | 6300 | 64487445 |
Ovarian cyst | 1861.45 | 49.09 | 365 | 4622 | 10653 | 64483092 |
Transplant rejection | 1740.63 | 49.09 | 373 | 4614 | 17028 | 64476717 |
Acne | 1603.20 | 49.09 | 367 | 4620 | 22714 | 64471031 |
Alopecia | 1061.45 | 49.09 | 416 | 4571 | 165274 | 64328471 |
Sleep disorder due to general medical condition, insomnia type | 473.69 | 49.09 | 144 | 4843 | 26126 | 64467619 |
Liver function test abnormal | 386.70 | 49.09 | 152 | 4835 | 59249 | 64434496 |
Multiple sclerosis relapse | 298.45 | 49.09 | 114 | 4873 | 41021 | 64452724 |
Rheumatoid arthritis | 239.94 | 49.09 | 152 | 4835 | 164142 | 64329603 |
Condition aggravated | 138.02 | 49.09 | 156 | 4831 | 372270 | 64121475 |
Loss of personal independence in daily activities | 133.55 | 49.09 | 78 | 4909 | 72376 | 64421369 |
Pneumonia | 118.89 | 49.09 | 178 | 4809 | 559398 | 63934347 |
Pain | 106.14 | 49.09 | 168 | 4819 | 553343 | 63940402 |
Incorrect route of product administration | 95.40 | 49.09 | 43 | 4944 | 23255 | 64470490 |
Product use issue | 85.79 | 49.09 | 80 | 4907 | 151635 | 64342110 |
Overdose | 82.35 | 49.09 | 80 | 4907 | 159486 | 64334259 |
Drug ineffective | 64.61 | 49.09 | 175 | 4812 | 840072 | 63653673 |
Encephalitis autoimmune | 50.08 | 49.09 | 14 | 4973 | 1870 | 64491875 |
None
Source | Code | Description |
---|---|---|
ATC | L04AC01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Interleukin inhibitors |
FDA MoA | N0000010279 | Interleukin 2 Receptor Antagonists |
MeSH PA | D007155 | Immunologic Factors |
MeSH PA | D007166 | Immunosuppressive Agents |
FDA MoA | N0000175621 | Interleukin 2 Receptor-directed Antibody Interactions |
FDA EPC | N0000175622 | Interleukin-2 Receptor Blocking Antibody |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Renal transplant rejection | indication | 236570004 | |
Relapsing remitting multiple sclerosis | indication | 426373005 | DOID:2378 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Interleukin-2 receptor | Membrane receptor | ANTIBODY BINDING | Kd | 8 | IUPHAR | DRUG LABEL |
ID | Source |
---|---|
D03639 | KEGG_DRUG |
4021083 | VUID |
N0000148541 | NUI |
4021083 | VANDF |
CHEMBL1201605 | ChEMBL_ID |
6880 | IUPHAR_LIGAND_ID |
7164 | INN_ID |
DB00111 | DRUGBANK_ID |
CUJ2MVI71Y | UNII |
1795335 | RXNORM |
11508 | MMSL |
241453 | MMSL |
4529 | MMSL |
d04262 | MMSL |
109133001 | SNOMEDCT_US |
386977009 | SNOMEDCT_US |
D000077561 | MESH_DESCRIPTOR_UI |
C0663182 | UMLSCUI |
007284 | NDDF |
None