rilonacept Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
interleukin-1 receptors 5105 501081-76-1

Description:

MoleculeDescription

Synonyms:

  • rilonacept
  • arcalyst
an anti-arthritis agent derived from IL-1R and IL-1RAcP
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
23 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 27, 2008 FDA REGENERON PHARMACEUTICALS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AC04 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
MeSH PA D000893 Anti-Inflammatory Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Cryopyrin associated periodic syndrome indication 430079001

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Interleukin-1 beta Cytokine INHIBITOR Kd 12.30 DRUG LABEL DRUG LABEL
Interleukin-1 alpha Cytokine INHIBITOR Kd 11.85 DRUG LABEL
Interleukin-1 receptor antagonist protein Unclassified INHIBITOR Kd 11.21 DRUG LABEL

External reference:

IDSource
D06635 KEGG_DRUG
4027340 VANDF
C2343505 UMLSCUI
CHEMBL1201830 ChEMBL_ID
DB06372 DRUGBANK_ID
6790 IUPHAR_LIGAND_ID
C531377 MESH_SUPPLEMENTAL_RECORD_UI
8750 INN_ID
8K80YB5GMG UNII
763450 RXNORM
136721 MMSL
25332 MMSL
d07138 MMSL
012583 NDDF
430868007 SNOMEDCT_US
434463003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Arcalyst HUMAN PRESCRIPTION DRUG LABEL 1 61755-001 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 160 mg SUBCUTANEOUS BLA 33 sections
Arcalyst HUMAN PRESCRIPTION DRUG LABEL 1 73604-914 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 160 mg SUBCUTANEOUS BLA 33 sections