DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
rilonacept 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
interleukin-1 receptors
5105
501081-76-1
Description:
Molecule
Description
Synonyms:
rilonacept
arcalyst
an anti-arthritis agent derived from IL-1R and IL-1RAcP
Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None
Drug dosage:
Dose
Unit
Route
23
mg
P
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
Feb. 27, 2008
FDA
REGENERON PHARMACEUTICALS
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Injection site erythema
73.69
44.84
25
363
83149
63405485
Injection site reaction
45.49
44.84
16
372
58508
63430126
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Injection site erythema
94.96
53.54
28
344
78169
79665847
Injection site mass
56.38
53.54
14
358
20170
79723846
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
L04AC04
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
MeSH PA
D000893
Anti-Inflammatory Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Cryopyrin associated periodic syndrome
indication
430079001
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Interleukin-1 beta
Cytokine
P01584
IL1B_HUMAN
INHIBITOR
Kd
12.30
DRUG LABEL
DRUG LABEL
Interleukin-1 alpha
Cytokine
P01583
IL1A_HUMAN
INHIBITOR
Kd
11.85
DRUG LABEL
Interleukin-1 receptor antagonist protein
Unclassified
P18510
IL1RA_HUMAN
INHIBITOR
Kd
11.22
DRUG LABEL
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External reference:
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ID
Source
012583
NDDF
136721
MMSL
25332
MMSL
4027340
VANDF
430868007
SNOMEDCT_US
434463003
SNOMEDCT_US
6790
IUPHAR_LIGAND_ID
763450
RXNORM
8750
INN_ID
8K80YB5GMG
UNII
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
Arcalyst
HUMAN PRESCRIPTION DRUG LABEL
1
73604-914
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
160 mg
SUBCUTANEOUS
BLA
33 sections
Arcalyst
HUMAN PRESCRIPTION DRUG LABEL
1
73604-914
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
160 mg
SUBCUTANEOUS
BLA
33 sections
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rilonacept