tocilizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4933 375823-41-9

Description:

MoleculeDescription

Synonyms:

  • tocilizumab
  • MRA
  • RoActemra
  • actemra
  • R-1569
  • tocilizumab (genetical recombination)
A humanised anti-interleukin-6 receptor monoclonal antibody. Its potential to combat cytokine release syndrome (CRS) in patients with severely ill COVID-19 was investigated. Accordingly, it is recommended to use tocilizumabin combination with dexamethasone (or another corticosteroid at an equivalent dose) in certain hospitalized patients who are exhibiting rapid respiratory decompensation caused by COVID-19.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
20 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 16, 2009 EMA Chugai Pharmaceutical Co., Ltd
Jan. 8, 2010 FDA GENENTECH
March 6, 2008 PMDA Chugai Pharmaceutical Co., Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4995.80 15.06 16833 410976 1027932 62033281
Contraindicated product administered 4428.58 15.06 6335 421474 211313 62849900
Joint swelling 3444.61 15.06 7113 420696 320553 62740660
Drug intolerance 3278.23 15.06 6730 421079 301931 62759282
Synovitis 3227.98 15.06 5042 422767 181876 62879337
Treatment failure 3123.66 15.06 5140 422669 193903 62867310
Arthropathy 2671.79 15.06 5272 422537 229520 62831693
Therapeutic product effect decreased 2431.70 15.06 4529 423280 188658 62872555
Pemphigus 2391.25 15.06 4370 423439 179356 62881857
Systemic lupus erythematosus 2222.47 15.06 4563 423246 204355 62856858
Swelling 1994.01 15.06 5168 422641 270210 62791003
Glossodynia 1979.01 15.06 3972 423837 174904 62886309
Hand deformity 1838.38 15.06 3603 424206 155854 62905359
Abdominal discomfort 1541.51 15.06 5206 422603 315679 62745534
Pain 1512.92 15.06 9318 418491 731310 62329903
Arthralgia 1469.76 15.06 7634 420175 562076 62499137
Hypersensitivity 1394.12 15.06 4736 423073 287949 62773264
Alopecia 1391.23 15.06 5208 422601 332328 62728885
Hepatic enzyme increased 1377.88 15.06 3714 424095 198614 62862599
Wound 1360.86 15.06 3236 424573 160027 62901186
Rheumatoid factor positive 1251.48 15.06 2128 425681 82278 62978935
Infusion related reaction 1241.54 15.06 4055 423754 241466 62819747
Anti-cyclic citrullinated peptide antibody positive 1220.18 15.06 2527 425282 113685 62947528
Death 1170.45 15.06 530 427279 373851 62687362
Toxicity to various agents 1131.48 15.06 161 427648 247089 62814124
Acute kidney injury 1059.53 15.06 239 427570 263176 62798037
Pericarditis 1057.19 15.06 2572 425237 129007 62932206
Musculoskeletal stiffness 978.54 15.06 3100 424709 181518 62879695
C-reactive protein abnormal 949.88 15.06 1353 426456 44743 63016470
Rheumatoid arthritis 949.08 15.06 3800 424009 250019 62811194
Drug interaction 945.54 15.06 196 427613 228935 62832278
Rash 917.48 15.06 6686 421123 554185 62507028
Anaemia 917.20 15.06 415 427394 293015 62768198
Lower respiratory tract infection 895.87 15.06 2425 425384 129882 62931331
Discomfort 870.85 15.06 2793 425016 164581 62896632
Peripheral swelling 862.18 15.06 3812 423997 262130 62799083
Infection 860.48 15.06 3436 424373 225737 62835476
Ill-defined disorder 817.19 15.06 1743 426066 80012 62981201
Product use issue 794.12 15.06 3264 424545 217256 62843957
Impaired healing 775.33 15.06 1959 425850 100583 62960630
Muscle injury 763.10 15.06 1486 426323 63859 62997354
Folliculitis 762.21 15.06 1550 426259 68767 62992446
Red blood cell sedimentation rate abnormal 751.35 15.06 791 427018 18991 63042222
Product dose omission issue 717.06 15.06 341 427468 233972 62827241
Dehydration 703.28 15.06 154 427655 173200 62888013
Helicobacter infection 684.13 15.06 1756 426053 91029 62970184
Duodenal ulcer perforation 666.41 15.06 1673 426136 85536 62975677
Loss of personal independence in daily activities 661.05 15.06 1786 426023 95504 62965709
Hyponatraemia 631.15 15.06 29 427780 111871 62949342
Irritable bowel syndrome 629.71 15.06 1581 426228 80831 62980382
Maternal exposure during pregnancy 619.46 15.06 3028 424781 217034 62844179
Febrile neutropenia 604.78 15.06 52 427757 118397 62942816
Constipation 592.37 15.06 394 427415 224549 62836664
Nausea 584.52 15.06 3379 424430 851092 62210121
Blister 580.87 15.06 2060 425749 127754 62933459
Red blood cell sedimentation rate increased 561.36 15.06 1039 426770 42943 63018270
Sleep disorder due to general medical condition, insomnia type 552.73 15.06 1140 426669 51077 63010136
Seizure 535.50 15.06 119 427690 132515 62928698
Drug hypersensitivity 533.84 15.06 3752 424057 306935 62754278
Tremor 481.63 15.06 146 427663 132093 62929120
Intentional overdose 481.60 15.06 3 427806 74149 62987064
Somnolence 471.63 15.06 312 427497 178373 62882840
Diarrhoea 470.85 15.06 2862 424947 712504 62348709
Injection site pain 466.10 15.06 147 427662 129653 62931560
Nasopharyngitis 464.01 15.06 3117 424692 251140 62810073
Hypotension 448.73 15.06 715 427094 271889 62789324
Dizziness 420.62 15.06 1487 426322 428438 62632775
C-reactive protein increased 416.70 15.06 1495 426314 93212 62968001
Anxiety 404.89 15.06 523 427286 217018 62844195
Cardiac arrest 403.06 15.06 69 427740 92476 62968737
Renal failure 400.24 15.06 146 427663 117506 62943707
Intentional product use issue 398.24 15.06 1813 425996 126079 62935134
Mobility decreased 390.32 15.06 1735 426074 119424 62941789
Rheumatoid nodule 389.83 15.06 528 427281 16627 63044586
Rheumatic fever 385.13 15.06 879 426930 42232 63018981
Cardiac failure congestive 383.14 15.06 78 427731 92355 62968858
Neuropathy peripheral 375.08 15.06 148 427661 113519 62947694
Bradycardia 374.14 15.06 32 427777 73195 62988018
Blood cholesterol increased 374.09 15.06 1437 426372 92595 62968618
Dyspnoea 373.49 15.06 2768 425041 658545 62402668
Bone erosion 363.28 15.06 519 427290 17198 63044015
Psoriatic arthropathy 361.11 15.06 1395 426414 90125 62971088
Electrocardiogram QT prolonged 358.14 15.06 9 427800 59521 63001692
Suicide attempt 356.28 15.06 12 427797 60906 63000307
Decreased appetite 356.03 15.06 722 427087 250330 62810883
Balance disorder 354.60 15.06 69 427740 84353 62976860
Sinusitis 354.20 15.06 2677 425132 223976 62837237
Malignant neoplasm progression 353.75 15.06 63 427746 82058 62979155
Tachycardia 353.47 15.06 177 427632 117979 62943234
Therapeutic product effect incomplete 352.95 15.06 1723 426086 123333 62937880
Knee arthroplasty 352.91 15.06 980 426829 53226 63007987
Gastrointestinal disorder 346.95 15.06 1775 426034 129464 62931749
Blood iron abnormal 343.15 15.06 251 427558 3625 63057588
Condition aggravated 342.98 15.06 4178 423631 398039 62663174
Thrombocytopenia 341.56 15.06 309 427500 150848 62910365
Overdose 340.34 15.06 175 427634 114903 62946310
Fall 338.53 15.06 1427 426382 390907 62670306
Hip arthroplasty 332.78 15.06 884 426925 46762 63014451
Inappropriate schedule of product administration 332.28 15.06 142 427667 103823 62957390
Feeling abnormal 332.15 15.06 306 427503 148086 62913127
Inflammation 331.09 15.06 1262 426547 81011 62980202
No adverse event 330.52 15.06 808 427001 40597 63020616
Asthenia 324.34 15.06 1406 426403 382198 62679015
Hypokalaemia 323.52 15.06 147 427662 103657 62957556
Stomatitis 322.34 15.06 1811 425998 136914 62924299
Depressed level of consciousness 320.25 15.06 26 427783 62052 62999161
Haemoglobin decreased 317.42 15.06 307 427502 145178 62916035
Depression 311.36 15.06 528 427281 195964 62865249
Joint stiffness 308.97 15.06 793 427016 41076 63020137
Swollen joint count increased 303.26 15.06 718 427091 35336 63025877
Hyperkalaemia 302.49 15.06 15 427794 54188 63007025
Chest discomfort 302.44 15.06 183 427626 109786 62951427
Vision blurred 299.48 15.06 122 427687 91802 62969411
Urinary tract infection 298.69 15.06 858 426951 263826 62797387
Hypoglycaemia 296.84 15.06 30 427779 60035 63001178
Respiratory failure 287.90 15.06 164 427645 101694 62959519
Vomiting 287.77 15.06 2402 425407 557215 62503998
Coma 284.67 15.06 46 427763 64318 62996895
Atrial fibrillation 283.65 15.06 222 427587 116414 62944799
Cognitive disorder 278.12 15.06 27 427782 55788 63005425
Off label use 277.36 15.06 6212 421597 668250 62392963
Pancytopenia 276.95 15.06 154 427655 96779 62964434
Cerebrovascular accident 276.39 15.06 195 427614 107829 62953384
Gastrointestinal haemorrhage 272.24 15.06 103 427706 81073 62980140
Cardio-respiratory arrest 271.67 15.06 40 427769 59919 63001294
Agitation 268.15 15.06 41 427768 59716 63001497
Wrong technique in product usage process 268.11 15.06 48 427761 62292 62998921
Rhabdomyolysis 266.86 15.06 6 427803 43945 63017268
Pulmonary embolism 266.59 15.06 236 427573 116448 62944765
Weight increased 265.28 15.06 2805 425004 257987 62803226
Deformity 259.99 15.06 356 427453 11328 63049885
Dysphagia 258.53 15.06 137 427672 88448 62972765
Cardiac failure 257.02 15.06 140 427669 89002 62972211
Gastrooesophageal reflux disease 253.55 15.06 166 427643 95473 62965740
COVID-19 253.33 15.06 233 427576 112870 62948343
Metabolic acidosis 253.02 15.06 12 427797 45057 63016156
Skin ulcer 249.96 15.06 747 427062 42298 63018915
Hallucination 249.69 15.06 36 427773 54781 63006432
Muscle spasms 248.78 15.06 418 427391 155732 62905481
Oedema peripheral 240.59 15.06 579 427230 188932 62872281
Disease progression 238.85 15.06 285 427524 122473 62938740
Osteoporosis 235.15 15.06 885 426924 56453 63004760
Abdominal pain 232.01 15.06 1102 426707 292354 62768859
International normalised ratio increased 227.30 15.06 24 427785 46401 63014812
Arthritis 226.75 15.06 1447 426362 114474 62946739
Hypoxia 225.00 15.06 62 427747 59730 63001483
Neutropenia 224.27 15.06 532 427277 174473 62886740
Syncope 223.64 15.06 277 427532 117108 62944105
Fibromyalgia 223.18 15.06 1103 426706 79317 62981896
Type 2 diabetes mellitus 222.70 15.06 937 426872 62931 62998282
Liver injury 220.54 15.06 900 426909 59620 63001593
Musculoskeletal pain 219.79 15.06 1213 426596 91064 62970149
Lethargy 218.52 15.06 54 427755 55953 63005260
Platelet count decreased 217.08 15.06 278 427531 115844 62945369
Pulmonary fibrosis 216.34 15.06 675 427134 39134 63022079
Incorrect dose administered 215.03 15.06 68 427741 59900 63001313
Panniculitis 213.81 15.06 320 427489 11065 63050148
Palpitations 212.86 15.06 268 427541 112502 62948711
Disturbance in attention 211.72 15.06 11 427798 38178 63023035
Epistaxis 211.43 15.06 113 427696 72612 62988601
Cough 208.32 15.06 1140 426669 291603 62769610
Suicidal ideation 207.97 15.06 80 427729 62341 62998872
Dysarthria 206.77 15.06 23 427786 42688 63018525
Granuloma skin 206.00 15.06 269 427540 8168 63053045
Coeliac disease 205.93 15.06 335 427474 12462 63048751
Blood parathyroid hormone decreased 205.41 15.06 290 427519 9501 63051712
Drug tolerance decreased 204.59 15.06 398 427411 17075 63044138
Sleep disorder 204.24 15.06 1087 426722 80479 62980734
Paraesthesia 203.64 15.06 474 427335 156492 62904721
Chronic obstructive pulmonary disease 201.25 15.06 85 427724 62601 62998612
Plasma cell myeloma 200.14 15.06 10 427799 35895 63025318
Injection site erythema 198.82 15.06 161 427648 83013 62978200
Sedation 198.11 15.06 17 427792 38792 63022421
Lactic acidosis 197.57 15.06 16 427793 38271 63022942
Deep vein thrombosis 195.63 15.06 166 427643 83634 62977579
Skin exfoliation 192.41 15.06 30 427779 43072 63018141
Hyperglycaemia 191.83 15.06 27 427782 41840 63019373
Disorientation 191.60 15.06 21 427788 39431 63021782
Disability assessment scale score increased 190.89 15.06 165 427644 3068 63058145
Foot deformity 190.64 15.06 513 427296 27340 63033873
Unresponsive to stimuli 189.84 15.06 9 427800 33807 63027406
Orthostatic hypotension 189.73 15.06 14 427795 36146 63025067
Myalgia 188.86 15.06 444 427365 146085 62915128
Pleural effusion 188.22 15.06 210 427599 93000 62968213
Joint destruction 185.81 15.06 220 427589 6032 63055181
Blood pressure diastolic abnormal 184.80 15.06 343 427466 14199 63047014
Neoplasm progression 183.14 15.06 17 427792 36411 63024802
Hypomagnesaemia 178.18 15.06 3 427806 28734 63032479
Blood glucose increased 177.71 15.06 181 427628 83575 62977638
Mental status changes 175.77 15.06 28 427781 39571 63021642
Chest pain 174.68 15.06 804 427005 215155 62846058
Sepsis 173.55 15.06 495 427314 152628 62908585
Respiratory arrest 173.12 15.06 12 427797 32633 63028580
Blood potassium decreased 168.93 15.06 38 427771 41988 63019225
Osteoarthritis 167.60 15.06 1159 426650 94184 62967029
Dysgeusia 167.41 15.06 53 427756 46657 63014556
Chills 164.00 15.06 322 427487 113056 62948157
Ascites 163.36 15.06 37 427772 40691 63020522
Joint range of motion decreased 161.79 15.06 534 427275 31894 63029319
Therapeutic response decreased 160.94 15.06 830 426979 60695 63000518
Ear pain 160.30 15.06 572 427237 35546 63025667
Dry skin 160.13 15.06 92 427717 56795 63004418
Dyspnoea exertional 159.35 15.06 105 427704 60197 63001016
Generalised tonic-clonic seizure 158.85 15.06 9 427800 29007 63032206
Hypophagia 158.72 15.06 14 427795 31245 63029968
Depressed mood 158.26 15.06 38 427771 40153 63021060
Mucosal inflammation 158.24 15.06 59 427750 46869 63014344
Hospitalisation 156.61 15.06 206 427603 84875 62976338
Flushing 156.21 15.06 165 427644 74922 62986291
Coronary artery disease 155.31 15.06 18 427791 32359 63028854
Sciatica 154.40 15.06 546 427263 33778 63027435
Dyskinesia 152.99 15.06 18 427791 31984 63029229
Pneumonia aspiration 152.02 15.06 25 427784 34515 63026698
Toxic epidermal necrolysis 151.73 15.06 4 427805 25330 63035883
Emotional distress 151.48 15.06 20 427789 32529 63028684
Blood pressure systolic abnormal 150.78 15.06 300 427509 13086 63048127
Blood alkaline phosphatase increased 150.03 15.06 51 427758 42916 63018297
Pulmonary oedema 149.87 15.06 92 427717 54781 63006432
Osteonecrosis of jaw 148.96 15.06 28 427781 35095 63026118
Bone pain 148.69 15.06 92 427717 54549 63006664
Pneumonia 148.64 15.06 2175 425634 454592 62606621
Blood calcium decreased 148.61 15.06 7 427802 26444 63034769
Memory impairment 148.30 15.06 299 427510 103959 62957254
Irritability 146.24 15.06 20 427789 31674 63029539
Restlessness 144.77 15.06 15 427794 29438 63031775
Intentional self-injury 143.66 15.06 7 427802 25680 63035533
Blood bilirubin increased 142.59 15.06 37 427772 37103 63024110
Skin necrosis 141.04 15.06 299 427510 13651 63047562
Blood pressure decreased 140.82 15.06 138 427671 64884 62996329
Haematochezia 140.45 15.06 94 427715 53450 63007763
Aggression 139.65 15.06 4 427805 23494 63037719
Pulmonary toxicity 139.41 15.06 238 427571 9217 63051996
Rectal haemorrhage 137.00 15.06 80 427729 48950 63012263
Tenosynovitis 136.38 15.06 293 427516 13502 63047711
Fatigue 135.02 15.06 7289 420520 880739 62180474
Psychotic disorder 134.77 15.06 10 427799 25702 63035511
Dysuria 134.62 15.06 31 427778 33707 63027506
Hypervolaemia 133.33 15.06 17 427792 28396 63032817
Abdominal distension 133.19 15.06 237 427572 86378 62974835
Limb deformity 132.68 15.06 149 427660 3853 63057360
Adverse event 131.21 15.06 842 426967 66717 62994496
Blood pressure systolic increased 129.98 15.06 648 427161 46749 63014464
Abnormal behaviour 129.78 15.06 3 427806 21423 63039790
Encephalopathy 129.47 15.06 49 427760 38571 63022642
Aphasia 128.37 15.06 32 427777 32968 63028245
Blood sodium decreased 128.35 15.06 9 427800 24243 63036970
Accidental exposure to product 127.15 15.06 17 427792 27388 63033825
Full blood count abnormal 126.84 15.06 29 427780 31688 63029525
Immunodeficiency 125.72 15.06 360 427449 19894 63041319
Musculoskeletal deformity 124.15 15.06 103 427706 1806 63059407
Blood pressure diastolic decreased 123.34 15.06 385 427424 22321 63038892
Intentional product misuse 123.23 15.06 137 427672 60780 63000433
Haemorrhage 122.61 15.06 138 427671 60884 63000329
Colitis 122.25 15.06 89 427720 48439 63012774
Drug reaction with eosinophilia and systemic symptoms 121.95 15.06 38 427771 33798 63027415
Pulmonary hypertension 121.31 15.06 49 427760 37074 63024139
Respiratory distress 120.82 15.06 39 427770 33912 63027301
Urinary retention 120.58 15.06 28 427781 30273 63030940
Haematuria 119.96 15.06 25 427784 29132 63032081
Muscle spasticity 119.74 15.06 371 427438 21423 63039790
Accidental overdose 119.55 15.06 10 427799 23299 63037914
Product quality issue 119.40 15.06 46 427763 35819 63025394
Chronic kidney disease 118.67 15.06 80 427729 45318 63015895
Foetal exposure during pregnancy 118.65 15.06 34 427775 31928 63029285
Jaundice 118.47 15.06 26 427783 29225 63031988
Sinus tachycardia 117.64 15.06 13 427796 24255 63036958
Immobile 117.30 15.06 171 427638 5772 63055441
Speech disorder 116.80 15.06 64 427745 40565 63020648
Ventricular tachycardia 116.58 15.06 4 427805 19975 63041238
Arrhythmia 115.72 15.06 56 427753 38084 63023129
Pollakiuria 114.85 15.06 24 427785 27913 63033300
Bone marrow failure 114.72 15.06 28 427781 29262 63031951
Stevens-Johnson syndrome 114.51 15.06 16 427793 24934 63036279
Angioedema 114.42 15.06 93 427716 47872 63013341
Full blood count decreased 114.16 15.06 19 427790 26005 63035208
Blood urea increased 114.09 15.06 20 427789 26359 63034854
Investigation abnormal 113.73 15.06 99 427710 1859 63059354
Renal disorder 113.64 15.06 40 427769 32934 63028279
Acute respiratory failure 113.54 15.06 45 427764 34440 63026773
Temperature regulation disorder 113.22 15.06 171 427638 5961 63055252
Diverticulitis 112.16 15.06 546 427263 39011 63022202
Hallucination, visual 112.13 15.06 4 427805 19294 63041919
Hepatic failure 111.82 15.06 50 427759 35606 63025607
Altered state of consciousness 111.62 15.06 18 427791 25212 63036001
Obstructive airways disorder 111.55 15.06 7 427802 20692 63040521
Mental disorder 111.34 15.06 20 427789 25899 63035314
Vertigo 111.23 15.06 144 427665 59743 63001470
Blood creatinine increased 110.89 15.06 269 427540 87575 62973638
Ejection fraction decreased 110.73 15.06 11 427798 22321 63038892
Transient ischaemic attack 110.69 15.06 58 427751 37695 63023518
Body temperature increased 110.26 15.06 520 427289 36672 63024541
Product prescribing error 109.28 15.06 22 427787 26267 63034946
Bursitis 109.16 15.06 517 427292 36524 63024689
Abortion spontaneous 108.29 15.06 95 427714 47100 63014113
Bronchitis chronic 108.16 15.06 140 427669 4213 63057000
Melaena 107.84 15.06 35 427774 30330 63030883
Diabetic ketoacidosis 107.40 15.06 8 427801 20497 63040716
White blood cell count decreased 107.06 15.06 527 427282 138577 62922636
Grip strength decreased 106.73 15.06 362 427447 21925 63039288
Injection site swelling 106.48 15.06 98 427711 47474 63013739
Body height below normal 106.38 15.06 100 427709 2083 63059130
Joint injury 106.29 15.06 438 427371 29134 63032079
Influenza like illness 106.24 15.06 179 427630 66645 62994568
Pericardial effusion 106.13 15.06 35 427774 30023 63031190
Presyncope 106.05 15.06 28 427781 27757 63033456
Feeling hot 105.46 15.06 110 427699 50244 63010969
Hemiparesis 104.38 15.06 16 427793 23266 63037947
Withdrawal syndrome 104.17 15.06 8 427801 19989 63041224
Blood pressure diastolic increased 104.04 15.06 217 427592 9793 63051420
Acute myocardial infarction 104 15.06 43 427766 32081 63029132
Tubulointerstitial nephritis 103.58 15.06 8 427801 19895 63041318
Night sweats 103.31 15.06 622 427187 48192 63013021
Circulatory collapse 103.24 15.06 13 427796 21925 63039288
Rash macular 102.62 15.06 17 427792 23347 63037866
Metastases to bone 102.54 15.06 11 427798 21008 63040205
Hyperhidrosis 101.09 15.06 379 427430 107457 62953756
Cholestasis 100.93 15.06 36 427773 29398 63031815
Device issue 100.75 15.06 19 427790 23762 63037451
Red blood cell sedimentation rate 100.68 15.06 143 427666 4711 63056502
Electrolyte imbalance 99.25 15.06 10 427799 20066 63041147
Drug eruption 99.23 15.06 420 427389 28274 63032939
Nightmare 99.09 15.06 8 427801 19186 63042027
Oral mucosal exfoliation 98.84 15.06 85 427724 1569 63059644
Pallor 98.83 15.06 41 427768 30527 63030686
Myocardial infarction 98.32 15.06 344 427465 99549 62961664
Macular degeneration 98.05 15.06 22 427787 24354 63036859
Staphylococcal infection 97.16 15.06 81 427728 41175 63020038
Infusion site pain 96.30 15.06 4 427805 16865 63044348
Joint laxity 96.17 15.06 100 427709 2364 63058849
Contusion 95.65 15.06 1481 426328 148563 62912650
Basal cell carcinoma 95.47 15.06 408 427401 27583 63033630
Haemophagocytic lymphohistiocytosis 95.22 15.06 217 427592 10410 63050803
Pyrexia 94.97 15.06 2429 425380 468049 62593164
Cardiomegaly 94.80 15.06 6 427803 17608 63043605
Human antichimeric antibody positive 94.23 15.06 84 427725 1630 63059583
Lip swelling 93.65 15.06 46 427763 31017 63030196
Cerebral haemorrhage 93.41 15.06 45 427764 30684 63030529
Haematemesis 93.26 15.06 44 427765 30368 63030845
Eating disorder 92.65 15.06 10 427799 19006 63042207
Device dislocation 92.40 15.06 29 427780 25676 63035537
Muscle twitching 91.72 15.06 12 427797 19656 63041557
Neutrophil count decreased 91.61 15.06 149 427660 56257 63004956
Muscular weakness 91.60 15.06 468 427341 121885 62939328
Intestinal obstruction 91.28 15.06 47 427762 30852 63030361
Therapeutic response unexpected 91.05 15.06 10 427799 18749 63042464
Thrombosis 90.97 15.06 187 427622 64568 62996645
Liver function test increased 90.96 15.06 450 427359 32361 63028852
Ulcer 90.17 15.06 382 427427 25725 63035488
Bone density decreased 89.99 15.06 259 427550 14353 63046860
Unevaluable event 89.94 15.06 129 427680 51257 63009956
Musculoskeletal disorder 89.94 15.06 325 427484 20319 63040894
Physical disability 88.87 15.06 101 427708 2647 63058566
Blood creatine phosphokinase increased 88.84 15.06 47 427762 30383 63030830
Vaginal haemorrhage 88.65 15.06 37 427772 27450 63033763
Diplopia 88.52 15.06 25 427784 23703 63037510
Frequent bowel movements 88.25 15.06 23 427786 22999 63038214
Treatment noncompliance 88.24 15.06 73 427736 37252 63023961
Nervousness 87.32 15.06 50 427759 30929 63030284
Visual acuity reduced 87.19 15.06 20 427789 21806 63039407
Myoclonus 86.62 15.06 5 427804 15863 63045350
Prescribed overdose 85.34 15.06 455 427354 33698 63027515
Clostridium difficile infection 84.76 15.06 48 427761 29874 63031339
Neutropenic sepsis 84.45 15.06 7 427802 16431 63044782
Pulmonary arterial hypertension 83.83 15.06 24 427785 22553 63038660
Small intestinal obstruction 83.59 15.06 12 427797 18325 63042888
Haematocrit decreased 83.44 15.06 85 427724 39255 63021958
Injection site pruritus 83.25 15.06 109 427700 45007 63016206
Multiple organ dysfunction syndrome 83.06 15.06 160 427649 56592 63004621
Caesarean section 82.87 15.06 9 427800 17023 63044190
Cardiac disorder 82.75 15.06 134 427675 50682 63010531
Rheumatoid factor negative 81.47 15.06 51 427758 560 63060653
Eye swelling 80.75 15.06 30 427779 23888 63037325
Upper gastrointestinal haemorrhage 80 15.06 15 427794 18837 63042376
Rheumatoid lung 79.28 15.06 113 427696 3735 63057478
Eczema 79.04 15.06 61 427748 32230 63028983
Acute hepatic failure 79.03 15.06 14 427795 18313 63042900
Onychomycosis 79.01 15.06 169 427640 7763 63053450
Gastritis 77.54 15.06 82 427727 37221 63023992
Hypersomnia 77.40 15.06 14 427795 18041 63043172
Tachypnoea 77.31 15.06 12 427797 17290 63043923
Haemoptysis 77.27 15.06 49 427760 28677 63032536
Blood glucose decreased 76.46 15.06 23 427786 20929 63040284
Coordination abnormal 76.24 15.06 4 427805 13769 63047444
Metastases to liver 75.95 15.06 32 427777 23607 63037606
Hypercholesterolaemia 75.90 15.06 315 427494 21019 63040194
Liver disorder 75.86 15.06 620 427189 53067 63008146
Surgical failure 75.37 15.06 58 427751 908 63060305
X-ray abnormal 75.34 15.06 168 427641 7942 63053271
Blood lactate dehydrogenase increased 74.74 15.06 31 427778 23085 63038128
Flatulence 74.72 15.06 74 427735 34628 63026585
Injection site mass 74.71 15.06 17 427792 18639 63042574
Sinus disorder 74.56 15.06 36 427773 24517 63036696
Prescribed underdose 74.50 15.06 396 427413 29293 63031920
Haematoma 74.12 15.06 75 427734 34745 63026468
Dystonia 73.50 15.06 5 427804 13814 63047399
Lymphocyte count decreased 73.00 15.06 58 427751 30199 63031014
Gamma-glutamyltransferase increased 72.78 15.06 73 427736 33958 63027255
Urinary incontinence 72.77 15.06 65 427744 31949 63029264
Clostridium difficile colitis 72.53 15.06 24 427785 20545 63040668
Product administration error 72.47 15.06 30 427779 22367 63038846
Mitral valve incompetence 72.44 15.06 21 427788 19573 63041640
Pneumonia viral 72.35 15.06 163 427646 7759 63053454
Hypothermia 71.99 15.06 5 427804 13576 63047637
Malaise 71.70 15.06 2195 425614 413759 62647454
Myelosuppression 71.60 15.06 35 427774 23668 63037545
Blood pressure fluctuation 71.54 15.06 546 427263 45771 63015442
Ataxia 71.52 15.06 9 427800 15186 63046027
Leukocytosis 71.48 15.06 43 427766 25892 63035321
Mood altered 71.20 15.06 8 427801 14735 63046478
Cyanosis 70.75 15.06 14 427795 16921 63044292
Hepatitis 70.65 15.06 485 427324 39303 63021910
Torsade de pointes 70.52 15.06 5 427804 13346 63047867
Tricuspid valve incompetence 70.44 15.06 8 427801 14613 63046600
Sinus bradycardia 70.01 15.06 8 427801 14543 63046670
Food allergy 69.16 15.06 201 427608 11200 63050013
Anal incontinence 69.14 15.06 6 427803 13570 63047643
Spinal column injury 69.09 15.06 77 427732 1974 63059239
Coagulopathy 68.97 15.06 26 427783 20518 63040695
Vascular access complication 68.75 15.06 78 427731 2040 63059173
Paraesthesia oral 68.73 15.06 22 427787 19234 63041979
Red cell distribution width decreased 68.66 15.06 77 427732 1988 63059225
Respiratory disorder 68.58 15.06 475 427334 38607 63022606
Weight decreased 68.19 15.06 1385 426424 275413 62785800
Faeces discoloured 68.13 15.06 20 427789 18489 63042724
Renal impairment 67.80 15.06 335 427474 88020 62973193
Swelling face 67.68 15.06 211 427598 63264 62997949
Ageusia 67.44 15.06 7 427802 13721 63047492
Mania 67.19 15.06 4 427805 12363 63048850
Heart rate decreased 67.00 15.06 531 427278 45029 63016184
Illness 66.95 15.06 144 427665 48915 63012298
Injection site warmth 66.86 15.06 11 427798 15184 63046029
Premature baby 66.73 15.06 28 427781 20707 63040506
Cardiogenic shock 66.69 15.06 19 427790 17913 63043300
Mean platelet volume decreased 66.57 15.06 86 427723 2583 63058630
Blood albumin decreased 66.53 15.06 10 427799 14756 63046457
Joint dislocation 66.42 15.06 277 427532 18523 63042690
Arthrodesis 66.36 15.06 88 427721 2713 63058500
Therapy non-responder 66.33 15.06 793 427016 75108 62986105
Agranulocytosis 66.07 15.06 44 427765 25090 63036123
Fear 65.94 15.06 13 427796 15753 63045460
Premature delivery 65.86 15.06 64 427745 30217 63030996
Anuria 65.44 15.06 5 427804 12546 63048667
Demyelination 65.01 15.06 144 427665 6776 63054437
Systemic lupus erythematosus rash 64.87 15.06 78 427731 2174 63059039
Pancreatitis 64.47 15.06 147 427662 48908 63012305
Right ventricular failure 64.32 15.06 18 427791 17170 63044043
Blood magnesium decreased 64.15 15.06 7 427802 13191 63048022
Toothache 64.05 15.06 278 427531 18921 63042292
Hyperlipidaemia 63.67 15.06 26 427783 19545 63041668
Multiple sclerosis 63.62 15.06 43 427766 24329 63036884
Exostosis 62.96 15.06 263 427546 17599 63043614
Iron deficiency anaemia 62.62 15.06 28 427781 19941 63041272
Incontinence 62.49 15.06 4 427805 11628 63049585
Face oedema 62.35 15.06 29 427780 20183 63041030
Oesophagitis 61.47 15.06 13 427796 14995 63046218
Hypophosphataemia 61.17 15.06 4 427805 11422 63049791
Dementia 61.09 15.06 25 427784 18769 63042444
Epilepsy 60.27 15.06 56 427753 27009 63034204
Colitis microscopic 59.91 15.06 168 427641 9171 63052042
Hypokinesia 59.33 15.06 11 427798 13925 63047288
Loose body in joint 59.04 15.06 57 427752 1229 63059984
Acute myeloid leukaemia 58.75 15.06 21 427788 17126 63044087
Disability 58.43 15.06 262 427547 18085 63043128
Joint effusion 58.43 15.06 249 427560 16811 63044402
Pancreatitis acute 58.41 15.06 58 427751 27108 63034105
Eosinophilia 58.27 15.06 41 427768 22715 63038498
General physical health deterioration 58.26 15.06 1773 426036 199629 62861584
Procedural pain 57.73 15.06 37 427772 21532 63039681
Asthma 57.59 15.06 565 427244 126996 62934217
Premature labour 57.43 15.06 8 427801 12496 63048717
Infusion site erythema 57.26 15.06 6 427803 11673 63049540
Joint arthroplasty 57.22 15.06 81 427728 2660 63058553
Nodule 56.60 15.06 286 427523 20740 63040473
Shock 56.57 15.06 45 427764 23418 63037795
Finger deformity 56.40 15.06 146 427663 7599 63053614
Hypovolaemia 56.37 15.06 4 427805 10669 63050544
Acute generalised exanthematous pustulosis 56.27 15.06 5 427804 11094 63050119
Sleep apnoea syndrome 56.24 15.06 68 427741 29065 63032148
Cardiomyopathy 56.18 15.06 24 427785 17560 63043653
Lower limb fracture 56.02 15.06 316 427493 23905 63037308
Polyarthritis 55.99 15.06 173 427636 9973 63051240
Rash papular 55.93 15.06 18 427791 15684 63045529
Ventricular fibrillation 55.92 15.06 7 427802 11860 63049353
Retching 55.43 15.06 15 427794 14630 63046583
Bedridden 55.13 15.06 182 427627 10869 63050344
Anti-cyclic citrullinated peptide antibody 55.10 15.06 133 427676 6625 63054588
Status epilepticus 55.09 15.06 17 427792 15216 63045997
Myocardial ischaemia 55.06 15.06 10 427799 12849 63048364
Antibody test positive 55.04 15.06 79 427730 2628 63058585
Brain oedema 54.76 15.06 14 427795 14181 63047032
Aspiration 54.71 15.06 5 427804 10846 63050367
Device difficult to use 54.69 15.06 10 427799 12786 63048427
Lung infiltration 54.39 15.06 15 427794 14448 63046765
Transplant rejection 54.26 15.06 5 427804 10775 63050438
Dislocation of vertebra 54.09 15.06 154 427655 8481 63052732
Hepatocellular injury 53.82 15.06 63 427746 27318 63033895
Impaired work ability 53.75 15.06 247 427562 17228 63043985
Obesity 53.71 15.06 366 427443 29586 63031627
Infusion site swelling 53.57 15.06 3 427806 9767 63051446
Dermatitis atopic 53.28 15.06 3 427806 9721 63051492
Adverse drug reaction 53.14 15.06 793 427016 78921 62982292
Body temperature decreased 53.03 15.06 274 427535 20045 63041168
Device malfunction 52.99 15.06 27 427782 17830 63043383
Deep vein thrombosis postoperative 52.98 15.06 183 427626 11186 63050027
Back pain 52.56 15.06 1366 426443 262779 62798434
Infusion site reaction 52.50 15.06 90 427719 3497 63057716
Red blood cell count decreased 52.44 15.06 123 427686 40522 63020691
Glomerular filtration rate decreased 52.34 15.06 13 427796 13428 63047785
Aplastic anaemia 52.28 15.06 3 427806 9566 63051647
Delusion 52.21 15.06 9 427800 12008 63049205
Left ventricular dysfunction 52.04 15.06 9 427800 11979 63049234
Subdural haematoma 51.80 15.06 16 427793 14312 63046901
Schizophrenia 51.79 15.06 4 427805 9948 63051265
Myelodysplastic syndrome 51.74 15.06 24 427785 16730 63044483
Cholecystitis chronic 51.64 15.06 5 427804 10356 63050857
Incorrect product administration duration 51.61 15.06 8 427801 11538 63049675
Renal injury 51.45 15.06 3 427806 9436 63051777
Hypoacusis 51.43 15.06 52 427757 24099 63037114
Blood pressure abnormal 51.41 15.06 19 427790 15179 63046034
Multiple fractures 51.38 15.06 151 427658 8467 63052746
Migraine 51.28 15.06 447 427362 102899 62958314
Hot flush 51.12 15.06 175 427634 50984 63010229
Anticipatory anxiety 51.05 15.06 52 427757 1199 63060014
Osteoporotic fracture 50.94 15.06 91 427718 3655 63057558
Blood calcium increased 50.87 15.06 3 427806 9347 63051866
Hypotonia 50.46 15.06 3 427806 9282 63051931
Malnutrition 50.30 15.06 20 427789 15278 63045935
Paranoia 50.19 15.06 9 427800 11670 63049543
Hypoaesthesia oral 49.99 15.06 13 427796 13020 63048193
Limb mass 49.83 15.06 83 427726 3149 63058064
Cholelithiasis 49.71 15.06 142 427667 43783 63017430
Atelectasis 49.58 15.06 43 427766 21440 63039773
Concomitant disease aggravated 49.35 15.06 3 427806 9109 63052104
Toxic skin eruption 49.14 15.06 13 427796 12872 63048341
Pharyngitis 48.72 15.06 266 427543 19877 63041336
Head injury 48.71 15.06 68 427741 27328 63033885
Neurotoxicity 48.49 15.06 27 427782 16963 63044250
Retinal toxicity 48.43 15.06 51 427758 1224 63059989
Skin discolouration 48.39 15.06 115 427694 37713 63023500
Metastases to lung 48.37 15.06 13 427796 12737 63048476
Urine output decreased 48.35 15.06 9 427800 11361 63049852
Gait inability 48.35 15.06 558 427251 52401 63008812
Haemodialysis 48.29 15.06 3 427806 8944 63052269
Erythema 48.28 15.06 863 426946 174888 62886325
Mean cell volume decreased 48.26 15.06 92 427717 3886 63057327
Tinnitus 48.26 15.06 105 427704 35523 63025690
Haematotoxicity 48.14 15.06 4 427805 9372 63051841
Hemiplegia 47.81 15.06 4 427805 9319 63051894
Pain of skin 47.81 15.06 10 427799 11624 63049589
Swollen tongue 47.60 15.06 102 427707 34698 63026515
Presbyacusis 47.46 15.06 76 427733 2789 63058424
Device breakage 47.27 15.06 10 427799 11532 63049681
Throat tightness 47.08 15.06 59 427750 24828 63036385
Vaginal discharge 47.02 15.06 4 427805 9194 63052019
Complication associated with device 47.00 15.06 28 427781 16950 63044263
Thirst 46.75 15.06 18 427791 14023 63047190
Anger 46.69 15.06 13 427796 12443 63048770
Deafness 46.45 15.06 32 427777 17925 63043288
Oliguria 46.41 15.06 4 427805 9097 63052116
Supraventricular tachycardia 46.36 15.06 19 427790 14252 63046961
Injection site bruising 46.33 15.06 137 427672 41773 63019440
Ankle arthroplasty 46.13 15.06 59 427750 1754 63059459
Wound infection 46.05 15.06 274 427535 21136 63040077
Eye pruritus 46.04 15.06 35 427774 18636 63042577
Pruritus allergic 45.91 15.06 55 427754 1527 63059686
Immune effector cell-associated neurotoxicity syndrome 45.64 15.06 66 427743 2211 63059002
Mesenteritis 45.62 15.06 28 427781 296 63060917
Ileus 45.62 15.06 21 427788 14704 63046509
Adjustment disorder with depressed mood 45.60 15.06 162 427647 10042 63051171
Atrial flutter 45.48 15.06 6 427803 9766 63051447
Injection site rash 45.44 15.06 36 427773 18773 63042440
Myopathy 45.21 15.06 10 427799 11181 63050032
Ischaemic stroke 45.13 15.06 33 427776 17924 63043289
Escherichia infection 44.76 15.06 15 427794 12739 63048474
Motor dysfunction 44.74 15.06 9 427800 10752 63050461
Skin burning sensation 44.65 15.06 15 427794 12719 63048494
Progressive multifocal leukoencephalopathy 44.24 15.06 16 427793 12955 63048258
Ventricular extrasystoles 44.18 15.06 12 427797 11675 63049538
Dermatitis contact 44.14 15.06 10 427799 10998 63050215
Intercepted product storage error 44.03 15.06 18 427791 70 63061143
Central nervous system lesion 43.99 15.06 9 427800 10626 63050587
Mood swings 43.99 15.06 35 427774 18213 63043000
Wheelchair user 43.85 15.06 117 427692 6202 63055011
Atrioventricular block complete 43.84 15.06 3 427806 8248 63052965
Fine motor skill dysfunction 43.75 15.06 99 427710 4726 63056487
Injection site urticaria 43.71 15.06 20 427789 14053 63047160
Nephropathy toxic 43.69 15.06 6 427803 9473 63051740
Posterior reversible encephalopathy syndrome 43.43 15.06 32 427777 17313 63043900
Hypocalcaemia 43.34 15.06 93 427716 31620 63029593
Oral candidiasis 43.18 15.06 54 427755 22744 63038469
Troponin increased 43.06 15.06 8 427801 10113 63051100
Facet joint syndrome 43 15.06 179 427630 11959 63049254
Rhinorrhoea 42.97 15.06 262 427547 65315 62995898
Device related infection 42.66 15.06 57 427752 23335 63037878
Breast cancer metastatic 42.41 15.06 14 427795 12004 63049209
Dysstasia 42.36 15.06 48 427761 21118 63040095
Productive cough 42.23 15.06 251 427558 62957 62998256
Haemodynamic instability 41.92 15.06 6 427803 9184 63052029
Apathy 41.90 15.06 5 427804 8789 63052424
Diverticular perforation 41.85 15.06 81 427728 3461 63057752
Drug level decreased 41.73 15.06 3 427806 7916 63053297
Chromaturia 41.65 15.06 31 427778 16686 63044527
Renal tubular necrosis 41.64 15.06 14 427795 11864 63049349
Injection site haemorrhage 41.60 15.06 62 427747 24252 63036961
Hysterectomy 41.52 15.06 7 427802 9492 63051721
Gastrointestinal perforation 41.45 15.06 80 427729 3411 63057802
Haemorrhoids 41.39 15.06 53 427756 22097 63039116
Transaminases abnormal 41.38 15.06 35 427774 631 63060582
Respiratory tract infection 41.38 15.06 142 427667 41341 63019872
Cutaneous vasculitis 41.15 15.06 102 427707 5167 63056046
Peptic ulcer haemorrhage 41.07 15.06 43 427766 1025 63060188
Oral herpes 40.61 15.06 308 427501 25766 63035447
Angina pectoris 40.45 15.06 89 427720 29989 63031224
Onychomadesis 40.39 15.06 108 427701 5732 63055481
Mean cell haemoglobin decreased 40.18 15.06 100 427709 5079 63056134
Dermatitis allergic 40.04 15.06 205 427604 14943 63046270
Hypothyroidism 39.82 15.06 150 427659 42482 63018731
Delirium 39.71 15.06 190 427619 50351 63010862
Sensory loss 39.68 15.06 10 427799 10228 63050985
Osteonecrosis 39.64 15.06 65 427744 24465 63036748
Hypoalbuminaemia 39.53 15.06 15 427794 11790 63049423
Cardiac failure acute 39.52 15.06 8 427801 9515 63051698
Glaucoma 39.42 15.06 240 427569 18665 63042548
Pleural fibrosis 39.32 15.06 78 427731 3394 63057819
Heavy menstrual bleeding 39.31 15.06 37 427772 17736 63043477
Retinitis 39.29 15.06 111 427698 6085 63055128
Bipolar disorder 39.26 15.06 4 427805 7956 63053257
Cold sweat 39.20 15.06 16 427793 12031 63049182
Hepatic cytolysis 39.13 15.06 28 427781 15379 63045834
Panic attack 39.13 15.06 56 427753 22275 63038938
Rhinitis allergic 39.10 15.06 15 427794 11712 63049501
Eructation 39.06 15.06 5 427804 8328 63052885
Haemolytic anaemia 39.03 15.06 10 427799 10115 63051098
Skin plaque 38.98 15.06 5 427804 8315 63052898
Arteriosclerosis 38.69 15.06 10 427799 10056 63051157
Tumour lysis syndrome 38.48 15.06 7 427802 8983 63052230
Sleep disorder due to a general medical condition 38.36 15.06 17 427792 12171 63049042
Device occlusion 38.35 15.06 3 427806 7384 63053829
Hepatic encephalopathy 38.34 15.06 14 427795 11268 63049945
Soft tissue disorder 38.19 15.06 89 427720 4333 63056880
Polyuria 38.00 15.06 6 427803 8536 63052677
Lip dry 37.90 15.06 205 427604 15265 63045948
Nail disorder 37.86 15.06 181 427628 12834 63048379
Eyelid ptosis 37.59 15.06 3 427806 7264 63053949
Skin papilloma 37.56 15.06 95 427714 4874 63056339
Growth failure 37.11 15.06 25 427784 314 63060899
Drug tolerance 36.98 15.06 117 427692 6832 63054381
Hyperthyroidism 36.83 15.06 27 427782 14646 63046567
Female genital tract fistula 36.76 15.06 4 427805 7555 63053658
Pleural thickening 36.62 15.06 68 427741 2815 63058398
Hospice care 36.61 15.06 5 427804 7927 63053286
Bundle branch block left 36.28 15.06 3 427806 7056 63054157
Peripheral sensory neuropathy 36.09 15.06 4 427805 7447 63053766
Abortion induced 36.03 15.06 12 427797 10230 63050983
Loss of consciousness 36.02 15.06 569 427240 117552 62943661
White blood cell count abnormal 35.91 15.06 108 427701 6134 63055079
Paralysis 35.89 15.06 11 427798 9889 63051324
Nasal congestion 35.76 15.06 277 427532 65383 62995830
Personality change 35.74 15.06 3 427806 6970 63054243
Metastases to lymph nodes 35.68 15.06 6 427803 8152 63053061
Herpes zoster 35.62 15.06 766 427043 81696 62979517
Genital haemorrhage 35.35 15.06 4 427805 7328 63053885
Drug use disorder 35.31 15.06 93 427716 4891 63056322
Stress cardiomyopathy 35.17 15.06 10 427799 9440 63051773
Poor quality sleep 34.92 15.06 50 427759 19885 63041328
Wrist deformity 34.59 15.06 56 427753 2074 63059139
Pulmonary haemorrhage 34.42 15.06 4 427805 7177 63054036
Thrombotic microangiopathy 34.40 15.06 14 427795 10547 63050666
Vitamin D deficiency 34.31 15.06 26 427783 13866 63047347
Hip fracture 34.30 15.06 94 427715 29380 63031833
Foetal growth restriction 34.30 15.06 5 427804 7548 63053665
Gallbladder disorder 34.27 15.06 46 427763 18796 63042417
Ocular hyperaemia 34.14 15.06 74 427735 25070 63036143
Breast cancer female 33.97 15.06 25 427784 13534 63047679
Product label confusion 33.91 15.06 51 427758 1771 63059442
Sputum discoloured 33.90 15.06 36 427773 16311 63044902
Device leakage 33.89 15.06 4 427805 7092 63054121
Electrocardiogram abnormal 33.63 15.06 10 427799 9169 63052044
Autoimmune hepatitis 33.59 15.06 8 427801 8502 63052711
Laboratory test abnormal 33.49 15.06 83 427726 26829 63034384
Juvenile idiopathic arthritis 33.28 15.06 71 427738 3255 63057958
Hiatus hernia 33.26 15.06 59 427750 21535 63039678
Toxic encephalopathy 33.25 15.06 3 427806 6576 63054637
Drug resistance 33.25 15.06 65 427744 22868 63038345
Synovial cyst 33.23 15.06 149 427660 10284 63050929
Dizziness postural 33.22 15.06 5 427804 7371 63053842
Hepatic function abnormal 33.21 15.06 133 427676 37009 63024204
Drug specific antibody 33.04 15.06 58 427751 2297 63058916
Lymphadenopathy 32.96 15.06 140 427669 38318 63022895
Restless legs syndrome 32.94 15.06 46 427763 18485 63042728
Infiltration anaesthesia 32.89 15.06 19 427790 178 63061035
Atrioventricular block 32.63 15.06 6 427803 7641 63053572
Breast cancer stage I 32.62 15.06 4 427805 6885 63054328
Generalised oedema 32.62 15.06 35 427774 15783 63045430
Anosmia 32.44 15.06 4 427805 6856 63054357
Shock haemorrhagic 32.43 15.06 13 427796 9882 63051331
Eyelid oedema 32.38 15.06 15 427794 10464 63050749
Second primary malignancy 32.34 15.06 7 427802 7946 63053267
Gastrointestinal toxicity 32.15 15.06 120 427689 7621 63053592
Infusion site extravasation 32.10 15.06 15 427794 10411 63050802
Wheezing 32.07 15.06 452 427357 95143 62966070
Vasculitic rash 32.05 15.06 43 427766 1341 63059872
Colitis ulcerative 32.05 15.06 81 427728 26010 63035203
Graft versus host disease 31.84 15.06 4 427805 6759 63054454
Amylase increased 31.79 15.06 3 427806 6342 63054871
Pre-eclampsia 31.60 15.06 11 427798 9122 63052091
Cytomegalovirus infection 31.59 15.06 58 427751 20894 63040319
Acute pulmonary oedema 31.56 15.06 8 427801 8150 63053063
Polyneuropathy 31.53 15.06 31 427778 14558 63046655
Interstitial lung disease 31.38 15.06 589 427220 61319 62999894
Orthopnoea 31.26 15.06 3 427806 6258 63054955
Hypercalcaemia 31.25 15.06 310 427499 28012 63033201
Viral infection 31.07 15.06 129 427680 35534 63025679
Rales 31.05 15.06 24 427785 12673 63048540
Gestational diabetes 31.03 15.06 9 427800 8387 63052826
Nystagmus 31.00 15.06 3 427806 6217 63054996
Cellulitis 30.99 15.06 378 427431 81580 62979633
Glycosylated haemoglobin increased 30.88 15.06 23 427786 12375 63048838
Torus fracture 30.87 15.06 17 427792 144 63061069
Lipase increased 30.86 15.06 14 427795 9886 63051327
Congestive cardiomyopathy 30.77 15.06 3 427806 6179 63055034
Expired product administered 30.76 15.06 3 427806 6178 63055035
Normal newborn 30.72 15.06 9 427800 8332 63052881
Initial insomnia 30.61 15.06 3 427806 6154 63055059
Atrial septal defect 30.58 15.06 5 427804 6933 63054280
Blood magnesium increased 30.57 15.06 65 427744 2973 63058240
Allergy to chemicals 30.51 15.06 65 427744 2977 63058236
Insurance issue 30.38 15.06 3 427806 6118 63055095
Pseudomonas infection 30.33 15.06 19 427790 11194 63050019
Activated partial thromboplastin time prolonged 30.31 15.06 5 427804 6888 63054325
Thinking abnormal 30.25 15.06 17 427792 10626 63050587
Metabolic disorder 30.25 15.06 4 427805 6499 63054714
Lupus vulgaris 30.15 15.06 99 427710 5895 63055318
Peripheral venous disease 30.09 15.06 193 427616 15284 63045929
Disease recurrence 30.00 15.06 93 427716 27937 63033276
Purpura 29.83 15.06 20 427789 11365 63049848
Respiration abnormal 29.72 15.06 4 427805 6413 63054800
Hepatomegaly 29.68 15.06 22 427787 11867 63049346
Odynophagia 29.62 15.06 7 427802 7479 63053734
Head discomfort 29.58 15.06 28 427781 13387 63047826
Lacrimation increased 29.46 15.06 59 427750 20572 63040641
Skin reaction 29.39 15.06 186 427623 14663 63046550
Angina unstable 29.36 15.06 6 427803 7089 63054124
Extra dose administered 29.31 15.06 4 427805 6346 63054867
Arteriosclerosis coronary artery 29.12 15.06 10 427799 8363 63052850
Viral upper respiratory tract infection 29.02 15.06 116 427693 7608 63053605
Bacteraemia 28.94 15.06 45 427764 17303 63043910
Maternal exposure timing unspecified 28.71 15.06 109 427700 6978 63054235
Hypovolaemic shock 28.65 15.06 4 427805 6237 63054976
Partial seizures 28.64 15.06 3 427806 5839 63055374
Hyperthermia 28.45 15.06 13 427796 9143 63052070
Facial pain 28.42 15.06 18 427791 10543 63050670
Intermenstrual bleeding 28.38 15.06 9 427800 7917 63053296
Extremity contracture 28.36 15.06 39 427770 1246 63059967
Middle insomnia 28.34 15.06 26 427783 12617 63048596
Lymphopenia 28.29 15.06 50 427759 18277 63042936
White blood cell count increased 28.29 15.06 201 427608 48360 63012853
Blood glucose abnormal 28.19 15.06 9 427800 7883 63053330
Iron deficiency 28.14 15.06 7 427802 7223 63053990
Bone swelling 28.07 15.06 45 427764 1653 63059560
Hyperventilation 27.88 15.06 4 427805 6112 63055101
Proctalgia 27.85 15.06 4 427805 6106 63055107
Acidosis 27.77 15.06 21 427788 11212 63050001
Immune reconstitution inflammatory syndrome 27.69 15.06 4 427805 6080 63055133
Therapy change 27.67 15.06 4 427805 6077 63055136
Eosinophil count increased 27.57 15.06 20 427789 10908 63050305
Arthritis bacterial 27.52 15.06 101 427708 6362 63054851
Needle issue 27.50 15.06 18 427791 10358 63050855
Malignant melanoma 27.49 15.06 150 427659 11206 63050007
Splenomegaly 27.40 15.06 21 427788 11136 63050077
Body height decreased 27.37 15.06 17 427792 10061 63051152
Taste disorder 27.32 15.06 31 427778 13631 63047582
Injection site induration 27.30 15.06 14 427795 9212 63052001
Blood creatine increased 27.15 15.06 3 427806 5598 63055615
Live birth 27.06 15.06 278 427531 25352 63035861
Flank pain 26.97 15.06 43 427766 16367 63044846
Eye pain 26.75 15.06 127 427682 33727 63027486
Therapy cessation 26.64 15.06 110 427699 30347 63030866
Product dose omission in error 26.63 15.06 9 427800 7603 63053610
Feeling cold 26.46 15.06 78 427731 23810 63037403
Coronary artery occlusion 26.45 15.06 11 427798 8180 63053033
Hereditary angioedema 26.35 15.06 9 427800 7553 63053660
Escherichia urinary tract infection 26.34 15.06 25 427784 11937 63049276
Dysphonia 26.33 15.06 200 427609 47414 63013799
Aortic arteriosclerosis 26.22 15.06 5 427804 6204 63055009
Emotional disorder 26.06 15.06 31 427778 13348 63047865
Metabolic encephalopathy 26.02 15.06 4 427805 5805 63055408
Pruritus 25.87 15.06 2798 425011 358655 62702558
Squamous cell carcinoma of skin 25.76 15.06 5 427804 6127 63055086
Atypical femur fracture 25.73 15.06 3 427806 5369 63055844
Hyperuricaemia 25.72 15.06 3 427806 5367 63055846
Hyperbilirubinaemia 25.68 15.06 23 427786 11291 63049922
Nervous system disorder 25.67 15.06 55 427754 18711 63042502
Prosthesis user 25.63 15.06 12 427797 69 63061144
Radiculopathy 25.58 15.06 13 427796 8598 63052615
Major depression 25.52 15.06 11 427798 8007 63053206
Blood disorder 25.51 15.06 7 427802 6764 63054449
Proteinuria 25.45 15.06 57 427752 19088 63042125
Herpes simplex 25.31 15.06 12 427797 8259 63052954
Cerebral ischaemia 25.26 15.06 7 427802 6721 63054492
Sneezing 25.25 15.06 53 427756 18165 63043048
Acute respiratory distress syndrome 25.24 15.06 78 427731 23456 63037757
Infusion site pruritus 25.19 15.06 5 427804 6030 63055183
Seronegative arthritis 25.18 15.06 71 427738 3888 63057325
Erythema multiforme 25.15 15.06 19 427790 10150 63051063
Urine abnormality 25.08 15.06 8 427801 7011 63054202
Vascular device infection 24.97 15.06 9 427800 7303 63053910
Acute coronary syndrome 24.94 15.06 19 427790 10107 63051106
Intestinal sepsis 24.93 15.06 19 427790 293 63060920
Abdominal pain lower 24.87 15.06 89 427720 25589 63035624
Therapeutic response shortened 24.85 15.06 26 427783 11862 63049351
Protein total decreased 24.85 15.06 5 427804 5972 63055241
Lower gastrointestinal haemorrhage 24.84 15.06 11 427798 7879 63053334
Decreased activity 24.83 15.06 6 427803 6314 63054899
Lower respiratory tract congestion 24.83 15.06 58 427751 2828 63058385
Skin haemorrhage 24.79 15.06 19 427790 10075 63051138
Blood loss anaemia 24.70 15.06 15 427794 8986 63052227
Metastasis 24.65 15.06 3 427806 5194 63056019
Myocarditis 24.64 15.06 20 427789 10305 63050908
Rheumatic disorder 24.55 15.06 60 427749 3012 63058201
Enthesopathy 24.48 15.06 119 427690 8495 63052718
Pulseless electrical activity 24.45 15.06 10 427799 7511 63053702
Extrasystoles 24.42 15.06 3 427806 5157 63056056
Blood thyroid stimulating hormone increased 24.32 15.06 9 427800 7185 63054028
Deafness neurosensory 24.25 15.06 80 427729 4775 63056438
Exercise tolerance decreased 24.14 15.06 4 427805 5493 63055720
Refusal of treatment by patient 24.14 15.06 4 427805 5493 63055720
Asphyxia 24.03 15.06 6 427803 6175 63055038
Drug ineffective for unapproved indication 23.96 15.06 133 427676 33930 63027283
Amenorrhoea 23.92 15.06 19 427790 9895 63051318
Proctitis 23.80 15.06 4 427805 5437 63055776
Brachiocephalic artery stenosis 23.77 15.06 9 427800 27 63061186
Fistula 23.74 15.06 21 427788 10372 63050841
Product temperature excursion issue 23.68 15.06 16 427793 202 63061011
Essential hypertension 23.64 15.06 3 427806 5030 63056183
Faecaloma 23.57 15.06 12 427797 7929 63053284
Gastric ulcer 23.49 15.06 83 427726 23954 63037259
Diabetic eye disease 23.47 15.06 14 427795 140 63061073
Product use in unapproved indication 23.46 15.06 977 426832 178103 62883110
Ear discomfort 23.39 15.06 12 427797 7894 63053319
Post procedural complication 23.39 15.06 50 427759 17024 63044189
Gastric haemorrhage 23.39 15.06 7 427802 6391 63054822
Blood urine present 23.36 15.06 41 427768 15028 63046185
Blood uric acid increased 23.36 15.06 4 427805 5363 63055850
Product physical issue 23.31 15.06 3 427806 4977 63056236
Jaw disorder 23.25 15.06 4 427805 5345 63055868
Nephropathy 23.07 15.06 7 427802 6334 63054879
Device failure 23.05 15.06 6 427803 6005 63055208
Cerebral infarction 23.01 15.06 83 427726 23810 63037403
Intervertebral disc compression 22.96 15.06 34 427775 1164 63060049
Crohn's disease 22.90 15.06 3 427806 4910 63056303
Adverse reaction 22.86 15.06 132 427677 10071 63051142
Cholecystectomy 22.72 15.06 23 427786 10654 63050559
Localised infection 22.71 15.06 307 427502 29903 63031310
Hepatitis cholestatic 22.60 15.06 9 427800 6869 63054344
Skin hyperpigmentation 22.53 15.06 6 427803 5915 63055298
Choking 22.52 15.06 20 427789 9859 63051354
Injection site hypersensitivity 22.43 15.06 46 427763 2051 63059162
Parosmia 22.31 15.06 7 427802 6199 63055014
Tension headache 22.28 15.06 4 427805 5182 63056031
Post procedural haemorrhage 22.24 15.06 13 427796 7951 63053262
Immune thrombocytopenia 22.17 15.06 23 427786 10533 63050680
Feeling jittery 22.14 15.06 35 427774 13368 63047845
Pharyngeal abscess 22.10 15.06 17 427792 266 63060947
Rib fracture 22.10 15.06 78 427731 22519 63038694
Embolism 21.94 15.06 13 427796 7893 63053320
Abnormal faeces 21.93 15.06 5 427804 5475 63055738
Neoscytalidium infection 21.90 15.06 7 427802 10 63061203
Lung disorder 21.86 15.06 562 427247 61699 62999514
Protein urine present 21.83 15.06 7 427802 6113 63055100
Short stature 21.70 15.06 25 427784 665 63060548
Pelvic pain 21.68 15.06 36 427773 13483 63047730
Carotid artery occlusion 21.56 15.06 3 427806 4691 63056522
Dry mouth 21.47 15.06 382 427427 77481 62983732
Cachexia 21.42 15.06 6 427803 5720 63055493
Localised oedema 21.34 15.06 5 427804 5373 63055840
Neutrophil count increased 21.33 15.06 50 427759 16477 63044736
Micturition urgency 21.27 15.06 20 427789 9591 63051622
Periorbital oedema 21.18 15.06 6 427803 5678 63055535
Dermatitis acneiform 21.15 15.06 4 427805 4992 63056221
Oesophageal candidiasis 21.06 15.06 6 427803 5657 63055556
Diabetes mellitus inadequate control 20.97 15.06 44 427765 15082 63046131
Bronchospasm 20.95 15.06 54 427755 17226 63043987
Dermatitis bullous 20.91 15.06 16 427793 8492 63052721
Tongue oedema 20.91 15.06 3 427806 4583 63056630
Tooth loss 20.90 15.06 10 427799 6846 63054367
Candida infection 20.88 15.06 109 427700 28242 63032971
Heparin-induced thrombocytopenia 20.88 15.06 3 427806 4579 63056634
Peripheral coldness 20.83 15.06 31 427778 12134 63049079
Injection site haematoma 20.77 15.06 10 427799 6822 63054391
Bacterial infection 20.65 15.06 65 427744 19434 63041779
Large intestine polyp 20.49 15.06 15 427794 8142 63053071
Laryngeal pain 20.37 15.06 3 427806 4495 63056718
Monocyte count increased 20.22 15.06 102 427707 7391 63053822
Azotaemia 20.21 15.06 3 427806 4468 63056745
Impaired gastric emptying 20.19 15.06 129 427680 10203 63051010
Bone cyst 20.16 15.06 46 427763 2208 63059005
Feeding disorder 20.14 15.06 37 427772 13325 63047888
Spinal osteoarthritis 20.07 15.06 50 427759 16136 63045077
Neuralgia 20.05 15.06 98 427711 25828 63035385
Crying 19.99 15.06 85 427724 23258 63037955
Wrist surgery 19.98 15.06 27 427782 848 63060365
Dermatitis exfoliative 19.91 15.06 6 427803 5453 63055760
Cardiac failure chronic 19.89 15.06 3 427806 4415 63056798
Accident 19.86 15.06 87 427722 5945 63055268
Gastrointestinal motility disorder 19.84 15.06 5 427804 5114 63056099
C-reactive protein 19.71 15.06 75 427734 4807 63056406
Femur fracture 19.70 15.06 393 427416 41363 63019850
Tooth infection 19.70 15.06 196 427613 17724 63043489
Toe amputation 19.70 15.06 42 427767 1925 63059288
Photosensitivity reaction 19.64 15.06 45 427764 14949 63046264
Mouth swelling 19.63 15.06 4 427805 4736 63056477
Petechiae 19.62 15.06 40 427769 13857 63047356
Sensory disturbance 19.61 15.06 39 427770 13633 63047580
Amyotrophic lateral sclerosis 19.47 15.06 31 427778 1132 63060081
Tongue disorder 19.39 15.06 130 427679 10450 63050763
Bunion operation 19.12 15.06 33 427776 1289 63059924
Onychoclasis 19.08 15.06 9 427800 6213 63055000
Pigmentation disorder 19.04 15.06 4 427805 4635 63056578
Injection site reaction 19.03 15.06 523 427286 58001 63003212
Vascular rupture 19.02 15.06 38 427771 1662 63059551
Blood fibrinogen decreased 18.99 15.06 26 427783 827 63060386
Hepatitis C 18.87 15.06 6 427803 5268 63055945
Epigastric discomfort 18.79 15.06 93 427716 6687 63054526
Menstruation irregular 18.76 15.06 12 427797 6992 63054221
Affective disorder 18.68 15.06 9 427800 6137 63055076
Urticaria 18.62 15.06 1327 426482 164475 62896738
Myositis 18.56 15.06 21 427788 9245 63051968
Rheumatoid vasculitis 18.53 15.06 17 427792 343 63060870
Ileus paralytic 18.52 15.06 4 427805 4547 63056666
Sudden death 18.51 15.06 26 427783 10423 63050790
Application site pain 18.46 15.06 3 427806 4179 63057034
Autoimmune disorder 18.46 15.06 187 427622 16990 63044223
Intestinal perforation 18.45 15.06 141 427668 11822 63049391
Defaecation urgency 18.42 15.06 3 427806 4172 63057041
Rhinovirus infection 18.39 15.06 4 427805 4525 63056688
Hepatotoxicity 18.28 15.06 351 427458 36690 63024523
Androgenetic alopecia 18.20 15.06 12 427797 145 63061068
Aplasia pure red cell 18.15 15.06 4 427805 4483 63056730
Rotator cuff syndrome 18.11 15.06 40 427769 13462 63047751
Hepatic cirrhosis 18.04 15.06 250 427559 24484 63036729
Cardiac murmur 18.01 15.06 45 427764 14507 63046706
Visual field defect 17.91 15.06 11 427798 6550 63054663
Musculoskeletal chest pain 17.91 15.06 77 427732 21006 63040207
Cardiac tamponade 17.87 15.06 5 427804 4770 63056443
Acute graft versus host disease 17.80 15.06 4 427805 4424 63056789
Sensation of foreign body 17.70 15.06 5 427804 4740 63056473
Klebsiella infection 17.61 15.06 19 427790 8547 63052666
Ankylosing spondylitis 17.61 15.06 126 427683 10348 63050865
Eye irritation 17.61 15.06 82 427727 21889 63039324
Pancreatic toxicity 17.58 15.06 7 427802 25 63061188
SARS-CoV-2 test positive 17.55 15.06 17 427792 8039 63053174
Impaired quality of life 17.55 15.06 42 427767 13741 63047472
Aortic stenosis 17.45 15.06 6 427803 5014 63056199
Concussion 17.40 15.06 22 427787 9222 63051991
Blindness 17.38 15.06 81 427728 21618 63039595
Premature rupture of membranes 17.30 15.06 6 427803 4987 63056226
Breast cancer recurrent 17.29 15.06 4 427805 4337 63056876
Pulmonary alveolar haemorrhage 17.26 15.06 5 427804 4663 63056550
Temperature intolerance 17.22 15.06 21 427788 8943 63052270
Nephrotic syndrome 17.20 15.06 8 427801 5568 63055645
Heart rate irregular 17.20 15.06 85 427724 22336 63038877
Pneumonitis 17.17 15.06 153 427656 35069 63026144
Product complaint 17.14 15.06 38 427771 12771 63048442
Blood iron decreased 17.09 15.06 47 427762 14674 63046539
Gastropleural fistula 17.09 15.06 8 427801 46 63061167
Normochromic normocytic anaemia 17.08 15.06 5 427804 4631 63056582
Post-traumatic stress disorder 17.04 15.06 7 427802 5244 63055969
Intercepted medication error 17.03 15.06 21 427788 601 63060612
Multiple system atrophy 17.03 15.06 13 427796 201 63061012
Metastatic neoplasm 17.03 15.06 4 427805 4291 63056922
Thrombocytosis 16.96 15.06 9 427800 5809 63055404
Hyperammonaemia 16.94 15.06 7 427802 5225 63055988
Lip oedema 16.91 15.06 3 427806 3921 63057292
Intracranial pressure increased 16.91 15.06 7 427802 5220 63055993
Psychiatric symptom 16.89 15.06 7 427802 5216 63055997
Upper-airway cough syndrome 16.87 15.06 32 427777 11386 63049827
Haemorrhagic stroke 16.83 15.06 9 427800 5783 63055430
Tendon disorder 16.81 15.06 81 427728 5762 63055451
Peptic ulcer 16.80 15.06 5 427804 4582 63056631
Decreased immune responsiveness 16.79 15.06 6 427803 4895 63056318
Low birth weight baby 16.78 15.06 14 427795 7115 63054098
Tooth extraction 16.77 15.06 27 427782 10237 63050976
Vaginal haematoma 16.75 15.06 11 427798 132 63061081
Back injury 16.70 15.06 117 427692 9543 63051670
Peritonitis bacterial 16.67 15.06 6 427803 4873 63056340
Glucose tolerance impaired 16.64 15.06 12 427797 6565 63054648
Pemphigoid 16.58 15.06 15 427794 7329 63053884
Hereditary motor and sensory neuropathy 16.51 15.06 10 427799 103 63061110
Headache 16.50 15.06 3899 423910 629342 62431871
Intentional dose omission 16.50 15.06 18 427791 8057 63053156
Gout 16.45 15.06 41 427768 13230 63047983
Infected bite 16.45 15.06 40 427769 2002 63059211
Peroneal nerve palsy 16.43 15.06 6 427803 4829 63056384
Thrombotic thrombocytopenic purpura 16.39 15.06 3 427806 3833 63057380
Photopsia 16.36 15.06 5 427804 4504 63056709
Cholecystitis acute 16.24 15.06 19 427790 8241 63052972
Lymphoedema 16.22 15.06 34 427775 11658 63049555
Injection site hyperaesthesia 16.16 15.06 8 427801 53 63061160
Pulse absent 16.13 15.06 8 427801 5366 63055847
Disability assessment scale score decreased 16.13 15.06 5 427804 6 63061207
Cerebral atrophy 16.05 15.06 7 427802 5059 63056154
Sinus headache 15.92 15.06 9 427800 5607 63055606
Pain in jaw 15.91 15.06 202 427607 43294 63017919
Injury 15.91 15.06 624 427185 72623 62988590
Blindness transient 15.84 15.06 3 427806 3741 63057472
Left ventricular hypertrophy 15.82 15.06 8 427801 5307 63055906
Bacterial test positive 15.78 15.06 8 427801 5299 63055914
Urine analysis abnormal 15.78 15.06 7 427802 5009 63056204
Pathogen resistance 15.77 15.06 12 427797 6386 63054827
Heart rate increased 15.75 15.06 499 427310 93739 62967474
Hydrocephalus 15.75 15.06 8 427801 5292 63055921
Tooth disorder 15.71 15.06 272 427537 27885 63033328
Bundle branch block right 15.68 15.06 7 427802 4991 63056222
Chronic sinusitis 15.67 15.06 40 427769 12803 63048410
Psoriasis 15.63 15.06 456 427353 86501 62974712
Ventricular septal defect 15.63 15.06 5 427804 4373 63056840
Disseminated large cell lymphoma 15.56 15.06 8 427801 58 63061155
Skin irritation 15.56 15.06 26 427783 9715 63051498
Movement disorder 15.55 15.06 84 427725 21577 63039636
Retinal haemorrhage 15.53 15.06 7 427802 4962 63056251
Adenoiditis 15.43 15.06 7 427802 37 63061176
Skin disorder 15.36 15.06 126 427683 29381 63031832
Abscess rupture 15.36 15.06 14 427795 280 63060933
Hypertonia 15.35 15.06 6 427803 4631 63056582
Gastric infection 15.27 15.06 55 427754 3432 63057781
Throat irritation 15.24 15.06 171 427638 37476 63023737
Facial bones fracture 15.22 15.06 4 427805 3978 63057235
Thiopurine methyltransferase decreased 15.22 15.06 15 427794 332 63060881
Foot operation 15.20 15.06 92 427717 7139 63054074
Apnoea 15.19 15.06 19 427790 8003 63053210
Seasonal allergy 15.18 15.06 81 427728 20869 63040344
Pulmonary mass 15.13 15.06 225 427584 22371 63038842
Duodenal ulcer 15.08 15.06 18 427791 7738 63053475
Carotid artery stenosis 15.07 15.06 8 427801 5162 63056051

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1880.79 14.44 3023 62285 416501 34475122
Drug ineffective 1683.17 14.44 3017 62291 453734 34437889
Joint swelling 1063.82 14.44 886 64422 59004 34832619
Synovitis 802.19 14.44 431 64877 13635 34877988
Contraindicated product administered 800.45 14.44 499 64809 20982 34870641
No adverse event 778.02 14.44 502 64806 22425 34869198
Intentional product use issue 691.42 14.44 696 64612 59120 34832503
Rheumatoid arthritis 619.32 14.44 537 64771 37701 34853922
Apparent death 576.24 14.44 227 65081 3417 34888206
Treatment failure 566.41 14.44 558 64750 46139 34845484
Bone erosion 548.10 14.44 225 65083 3790 34887833
Therapeutic product effect decreased 506.90 14.44 460 64848 34283 34857340
Diverticulitis 498.18 14.44 362 64946 19642 34871981
Arthropathy 497.56 14.44 408 64900 26499 34865124
C-reactive protein abnormal 468.94 14.44 257 65051 8453 34883170
Drug intolerance 460.93 14.44 562 64746 59008 34832615
Red blood cell sedimentation rate abnormal 376.83 14.44 167 65141 3422 34888201
Arthralgia 350.19 14.44 893 64415 169148 34722475
Drug eruption 314.93 14.44 276 65032 19622 34872001
Pain 308.65 14.44 960 64348 203715 34687908
Urticaria 290.42 14.44 461 64847 61916 34829707
Toxicity to various agents 285.34 14.44 24 65284 200338 34691285
Stomatitis 265.61 14.44 361 64947 42153 34849470
Red blood cell sedimentation rate increased 230.70 14.44 167 65141 8995 34882628
Hypersensitivity 219.19 14.44 402 64906 60633 34830990
Drug hypersensitivity 217.76 14.44 471 64837 80058 34811565
Pain in extremity 212.50 14.44 617 64691 125896 34765727
Musculoskeletal stiffness 206.24 14.44 337 64971 46343 34845280
Hepatic function abnormal 198.32 14.44 322 64986 44041 34847582
Rheumatoid factor negative 181.69 14.44 67 65241 832 34890791
Diarrhoea 178.46 14.44 284 65024 389628 34501995
Ill-defined disorder 171.70 14.44 168 65140 13741 34877882
Drug abuse 170.02 14.44 3 65305 99093 34792530
Peripheral swelling 168.60 14.44 413 64895 76128 34815495
Pulmonary thrombosis 168.47 14.44 127 65181 7280 34884343
Bone cyst 166.50 14.44 74 65234 1526 34890097
C-reactive protein increased 165.53 14.44 333 64975 53765 34837858
Completed suicide 164.35 14.44 4 65304 98164 34793459
Anaemia 159.32 14.44 122 65186 233213 34658410
Knee arthroplasty 156.93 14.44 122 65186 7322 34884301
Mobility decreased 154.52 14.44 233 65075 29895 34861728
Loss of personal independence in daily activities 152.58 14.44 244 65064 32935 34858688
Anti-cyclic citrullinated peptide antibody positive 150.38 14.44 72 65236 1771 34889852
Febrile neutropenia 145.59 14.44 38 65270 136811 34754812
Vomiting 144.43 14.44 150 65158 247471 34644152
Terminal state 142.87 14.44 90 65218 3844 34887779
Hand deformity 139.76 14.44 87 65221 3638 34887985
Acute kidney injury 135.71 14.44 226 65082 304762 34586861
Blood pressure diastolic abnormal 135.58 14.44 94 65214 4724 34886899
Limb discomfort 135.54 14.44 133 65175 10914 34880709
Drug interaction 135.00 14.44 134 65174 225812 34665811
Fatigue 132.04 14.44 313 64995 370340 34521283
Immune effector cell-associated neurotoxicity syndrome 129.99 14.44 83 65225 3630 34887993
Herpes zoster 129.02 14.44 231 65077 34168 34857455
Infusion related reaction 125.06 14.44 294 65014 52763 34838860
Joint ankylosis 123.98 14.44 60 65248 1512 34890111
Swelling 123.89 14.44 256 65052 42110 34849513
Interstitial lung disease 122.77 14.44 332 64976 64950 34826673
Arthritis bacterial 121.58 14.44 90 65218 5016 34886607
Impaired work ability 121.55 14.44 102 65206 6828 34884795
Localised infection 121.54 14.44 157 65151 17430 34874193
Overdose 121.34 14.44 14 65294 91045 34800578
Dehydration 120.58 14.44 46 65262 129923 34761700
Skin ulcer 119.91 14.44 176 65132 22040 34869583
Confusional state 113.68 14.44 64 65244 144096 34747527
Haemophagocytic lymphohistiocytosis 112.68 14.44 130 65178 12843 34878780
Drug specific antibody present 109 14.44 71 65237 3214 34888409
Epistaxis 107.27 14.44 294 65014 57957 34833666
Mass 106.09 14.44 100 65208 7805 34883818
Death 103.56 14.44 389 64919 397660 34493963
Alanine aminotransferase abnormal 103.55 14.44 79 65229 4609 34887014
Joint arthroplasty 101.76 14.44 44 65264 847 34890776
Dyspnoea 97.46 14.44 369 64939 376413 34515210
Deep vein thrombosis 95.96 14.44 304 65004 64944 34826679
Hypofibrinogenaemia 94.18 14.44 51 65257 1635 34889988
Blood pressure systolic increased 91.04 14.44 158 65150 22794 34868829
Bronchopulmonary aspergillosis 90.73 14.44 124 65184 14535 34877088
Blood pressure systolic abnormal 90.45 14.44 68 65240 3880 34887743
Gastric disorder 89.00 14.44 113 65195 12328 34879295
Dizziness 88.01 14.44 172 65136 218349 34673274
Asthenia 87.20 14.44 207 65101 245044 34646579
Bladder transitional cell carcinoma 87.15 14.44 57 65251 2598 34889025
Arthritis 86.49 14.44 185 65123 31161 34860462
Intestinal sepsis 86.13 14.44 36 65272 635 34890988
Hyponatraemia 85.93 14.44 24 65284 82667 34808956
Malignant neoplasm progression 85.30 14.44 29 65279 88017 34803606
Cytokine release syndrome 83.68 14.44 152 65156 22725 34868898
Intestinal polyp 83.16 14.44 40 65268 994 34890629
Constipation 81.97 14.44 81 65227 136901 34754722
Nodule 81.60 14.44 81 65227 6738 34884885
Drug ineffective for unapproved indication 81.01 14.44 153 65155 23562 34868061
Nasopharyngitis 81.00 14.44 301 65007 69667 34821956
Joint lock 80.92 14.44 42 65266 1233 34890390
Decreased appetite 78.85 14.44 118 65190 166274 34725349
Gait inability 78.58 14.44 140 65168 20618 34871005
Infection 78.31 14.44 357 64951 90558 34801065
Pulmonary embolism 77.74 14.44 353 64955 89393 34802230
Cardiac failure congestive 76.31 14.44 30 65278 83240 34808383
X-ray abnormal 76.15 14.44 30 65278 451 34891172
Osteolysis 76.10 14.44 56 65252 3092 34888531
Cytology abnormal 74.14 14.44 28 65280 373 34891250
Sleep disorder due to general medical condition, insomnia type 74.04 14.44 40 65268 1276 34890347
Rheumatoid nodule 72.54 14.44 53 65255 2894 34888729
General physical health deterioration 72.07 14.44 80 65228 128189 34763434
Somnolence 72.05 14.44 61 65247 111055 34780568
Polyarthritis 71.83 14.44 63 65245 4477 34887146
Physical disability 71.75 14.44 40 65268 1359 34890264
Pyrexia 70.81 14.44 351 64957 332662 34558961
Loss of consciousness 70.63 14.44 33 65275 82634 34808989
Hyperkalaemia 70.50 14.44 21 65287 69368 34822255
Seizure 68.68 14.44 57 65251 104800 34786823
Hepatitis B virus test positive 68.41 14.44 25 65283 302 34891321
Blood pressure diastolic increased 68.26 14.44 64 65244 4961 34886662
Hypokalaemia 68.21 14.44 13 65295 58201 34833422
Syncope 67.29 14.44 44 65264 91407 34800216
Rhabdomyolysis 66.80 14.44 22 65286 68141 34823482
Blood pressure diastolic decreased 65.68 14.44 83 65225 9011 34882612
Drug use disorder 64 14.44 57 65251 4134 34887489
Oxygen saturation decreased 63.50 14.44 233 65075 53585 34838038
Pulmonary fibrosis 63.22 14.44 119 65189 18277 34873346
Product dose omission issue 62.60 14.44 79 65229 119632 34771991
Rheumatoid factor positive 62.07 14.44 29 65279 674 34890949
Drug tolerance decreased 61.58 14.44 41 65267 1926 34889697
Coma 60.88 14.44 7 65301 45671 34845952
Malaise 60.43 14.44 164 65144 185661 34705962
Photosensitivity reaction 60.17 14.44 86 65222 10508 34881115
Incorrect dose administered 59.97 14.44 4 65304 40511 34851112
Dysphagia 59.62 14.44 21 65287 62360 34829263
Hepatitis 59.06 14.44 135 65173 23769 34867854
Hospitalisation 58.21 14.44 17 65291 56885 34834738
Skin laceration 57.48 14.44 92 65216 12417 34879206
Depression 57.38 14.44 58 65250 97040 34794583
Abdominal distension 57.10 14.44 19 65289 58473 34833150
Therapeutic product effect incomplete 56.45 14.44 215 65093 50326 34841297
Disability 55.91 14.44 56 65252 4709 34886914
Vision blurred 54.41 14.44 10 65298 45953 34845670
Disability assessment scale score increased 54.40 14.44 20 65288 246 34891377
Gastrointestinal haemorrhage 53.26 14.44 52 65256 88425 34803198
Fall 52.72 14.44 198 65110 202687 34688936
Plasma cell myeloma 52.30 14.44 8 65300 42029 34849594
Osteoarthritis 51.46 14.44 117 65191 20525 34871098
Joint stiffness 51.38 14.44 81 65227 10792 34880831
Seronegative arthritis 51.36 14.44 29 65279 1010 34890613
Drug effective for unapproved indication 51.30 14.44 41 65267 2561 34889062
Immobile 50.67 14.44 40 65268 2454 34889169
International normalised ratio increased 50.54 14.44 13 65295 47314 34844309
Muscle spasms 50.01 14.44 274 65034 74727 34816896
Hallucination 49.79 14.44 17 65291 51481 34840142
Suicidal ideation 49.54 14.44 8 65300 40380 34851243
Unevaluable event 48.88 14.44 3 65305 32587 34859036
Liver function test increased 48.54 14.44 93 65215 14472 34877151
Hepatic steatosis 47.93 14.44 106 65202 18256 34873367
Hip arthroplasty 47.76 14.44 50 65258 4429 34887194
Abdominal pain 47.66 14.44 152 65156 163466 34728157
Lymphoedema 46.88 14.44 47 65261 3956 34887667
Prerenal failure 45.76 14.44 35 65273 2049 34889574
Liver disorder 45.09 14.44 150 65158 32847 34858776
Musculoskeletal discomfort 45.09 14.44 65 65243 8003 34883620
Wrong technique in product usage process 44.42 14.44 7 65301 35979 34855644
Blood glucose increased 44.00 14.44 36 65272 66682 34824941
Skin mass 43.42 14.44 45 65263 3940 34887683
Suicide attempt 43.22 14.44 10 65298 39106 34852517
Inappropriate schedule of product administration 43.12 14.44 32 65276 62264 34829359
Anxiety 42.83 14.44 75 65233 99353 34792270
Haematuria 42.73 14.44 20 65288 50046 34841577
Stent placement 42.61 14.44 50 65258 5028 34886595
Heart rate decreased 42.22 14.44 143 65165 31602 34860021
Oral surgery 42.03 14.44 21 65287 568 34891055
Hypoglycaemia 41.95 14.44 25 65283 54615 34837008
Agitation 41.68 14.44 28 65280 57371 34834252
Atrial fibrillation 41.28 14.44 106 65202 122287 34769336
Myalgia 40.42 14.44 59 65249 84051 34807572
Depressed level of consciousness 39.95 14.44 15 65293 42826 34848797
Mental status changes 39.64 14.44 11 65297 38072 34853551
Blood fibrinogen decreased 39.38 14.44 26 65282 1204 34890419
Aggression 39.19 14.44 12 65296 38952 34852671
Dysarthria 38.21 14.44 9 65299 34773 34856850
Medical device implantation 37.96 14.44 20 65288 606 34891017
Juvenile idiopathic arthritis 37.63 14.44 30 65278 1867 34889756
Musculoskeletal pain 37.36 14.44 138 65170 31825 34859798
Hepatic cirrhosis 36.54 14.44 92 65216 17222 34874401
Restlessness 36.33 14.44 3 65305 25479 34866144
Panniculitis 36.31 14.44 30 65278 1964 34889659
Blood creatinine increased 36.24 14.44 77 65231 94899 34796724
Pancytopenia 35.60 14.44 78 65230 95079 34796544
Thrombocytopenia 35.24 14.44 161 65147 156086 34735537
Systemic candida 35.18 14.44 39 65269 3687 34887936
Septic shock 34.97 14.44 242 65066 71592 34820031
Renal impairment 34.92 14.44 78 65230 94435 34797188
Joint injury 34.88 14.44 62 65246 9111 34882512
Skin exfoliation 34.63 14.44 5 65303 27427 34864196
Coronary artery disease 34.49 14.44 24 65284 48281 34843342
Weight increased 34.45 14.44 294 65014 92739 34798884
Lactic acidosis 34.45 14.44 11 65297 34761 34856862
Mycotic endophthalmitis 33.91 14.44 11 65297 90 34891533
Hypotension 33.27 14.44 260 65048 221389 34670234
Red blood cell sedimentation rate 33.00 14.44 23 65285 1165 34890458
Cytokine storm 32.91 14.44 19 65289 691 34890932
Abscess 32.87 14.44 70 65238 11747 34879876
Infectious pleural effusion 32.67 14.44 31 65277 2439 34889184
Cardio-respiratory arrest 32.66 14.44 33 65275 55240 34836383
Fine motor skill dysfunction 32.58 14.44 27 65281 1775 34889848
Disorientation 32.00 14.44 11 65297 33177 34858446
Soft tissue swelling 31.56 14.44 17 65291 539 34891084
Hepatic enzyme abnormal 31.52 14.44 32 65276 2734 34888889
Intentional product misuse 30.83 14.44 24 65284 45587 34846036
Haematemesis 30.78 14.44 7 65301 27704 34863919
Unresponsive to stimuli 30.55 14.44 7 65301 27562 34864061
Inflammation 30.46 14.44 119 65189 28176 34863447
Body temperature decreased 30.42 14.44 72 65236 12962 34878661
Abscess limb 30.12 14.44 35 65273 3482 34888141
Chronic kidney disease 30.06 14.44 20 65288 41190 34850433
Neoplasm progression 29.99 14.44 4 65304 23296 34868327
Diabetes mellitus 29.73 14.44 169 65139 46704 34844919
COVID-19 pneumonia 29.58 14.44 84 65224 16883 34874740
Granuloma skin 29.23 14.44 22 65286 1257 34890366
Disseminated mucormycosis 29.23 14.44 16 65292 524 34891099
Amnesia 28.93 14.44 7 65301 26556 34865067
Neuropathy peripheral 28.92 14.44 71 65237 83192 34808431
Therapy non-responder 28.80 14.44 147 65161 38999 34852624
Intercepted product storage error 28.44 14.44 12 65296 217 34891406
Paraesthesia 27.99 14.44 48 65260 64124 34827499
Irritability 27.90 14.44 6 65302 24684 34866939
Hypomagnesaemia 27.54 14.44 4 65304 21847 34869776
Herpes simplex viraemia 27.50 14.44 9 65299 76 34891547
Dry mouth 27.40 14.44 11 65297 30154 34861469
Therapeutic response decreased 27.38 14.44 118 65190 29195 34862428
Urinary retention 27.30 14.44 17 65291 36271 34855352
Muscle strain 26.69 14.44 35 65273 3941 34887682
Interleukin level increased 26.56 14.44 10 65298 132 34891491
Bursitis 26.26 14.44 41 65267 5417 34886206
Gait disturbance 26.25 14.44 77 65231 85063 34806560
Tubulointerstitial nephritis 26.15 14.44 4 65304 21020 34870603
Human herpesvirus 6 encephalitis 26.01 14.44 13 65295 352 34891271
Gastrointestinal perforation 25.92 14.44 34 65274 3829 34887794
Rheumatoid lung 25.61 14.44 18 65290 924 34890699
Blood pressure fluctuation 25.42 14.44 104 65204 25145 34866478
Mucosal inflammation 25.26 14.44 21 65287 38601 34853022
Chills 25.20 14.44 73 65235 80970 34810653
Polyarteritis nodosa 25.18 14.44 12 65296 292 34891331
Lethargy 24.92 14.44 24 65284 41098 34850525
Skin injury 24.69 14.44 26 65282 2319 34889304
Injection site pain 24.54 14.44 22 65286 38983 34852640
Pharyngitis 24.38 14.44 49 65259 7895 34883728
Blood parathyroid hormone decreased 24.35 14.44 21 65287 1459 34890164
Oedema 24.08 14.44 30 65278 45711 34845912
Visual impairment 23.99 14.44 19 65289 35783 34855840
Rheumatoid factor 23.80 14.44 8 65300 74 34891549
Hepatitis E antibody positive 23.53 14.44 11 65297 256 34891367
Chest pain 23.30 14.44 140 65168 126622 34765001
Dyspnoea exertional 23.18 14.44 28 65280 43251 34848372
Rheumatoid factor increased 23.18 14.44 14 65294 554 34891069
Ascites 23.02 14.44 32 65276 46539 34845084
Lymphocyte adoptive therapy 22.97 14.44 5 65303 5 34891618
Hepatic enzyme increased 22.90 14.44 138 65170 38942 34852681
Nausea 22.90 14.44 473 64835 339435 34552188
Shoulder operation 22.75 14.44 18 65290 1108 34890515
Respiratory arrest 22.72 14.44 12 65296 28031 34863592
Disturbance in attention 22.70 14.44 10 65298 25935 34865688
Cholestasis 22.63 14.44 11 65297 26937 34864686
Angioedema 22.43 14.44 22 65286 37352 34854271
Hepatitis E virus test positive 22.34 14.44 11 65297 288 34891335
Large intestine perforation 22.09 14.44 49 65259 8454 34883169
Drug withdrawal syndrome 22.05 14.44 5 65303 19829 34871794
Bradycardia 21.97 14.44 70 65238 75348 34816275
Neutrophil count increased 21.94 14.44 3 65305 17143 34874480
White blood cell count increased 21.65 14.44 27 65281 41124 34850499
Metabolic acidosis 21.60 14.44 30 65278 43650 34847973
Rectal haemorrhage 21.60 14.44 26 65282 40223 34851400
Ulcerative keratitis 21.54 14.44 21 65287 1708 34889915
Injection site hypersensitivity 21.51 14.44 11 65297 313 34891310
Lower respiratory tract congestion 21.39 14.44 18 65290 1209 34890414
Arthritis infective 21.27 14.44 29 65279 3390 34888233
Jaundice 21.26 14.44 17 65291 31865 34859758
Pneumatosis intestinalis 21.04 14.44 31 65277 3892 34887731
Poor venous access 20.96 14.44 36 65272 5147 34886476
Infective chondritis 20.95 14.44 5 65303 10 34891613
Osteonecrosis of jaw 20.94 14.44 4 65304 17885 34873738
Infective spondylitis 20.77 14.44 10 65298 249 34891374
Oral disorder 20.55 14.44 32 65276 4217 34887406
Dysgeusia 20.51 14.44 12 65296 26485 34865138
Pulmonary toxicity 20.17 14.44 39 65269 6108 34885515
Myocardial ischaemia 20.15 14.44 4 65304 17404 34874219
Thrombosis 20.02 14.44 162 65146 50296 34841327
Disseminated intravascular coagulation 19.74 14.44 87 65221 21729 34869894
Tooth injury 19.62 14.44 17 65291 1188 34890435
Toxic epidermal necrolysis 19.49 14.44 8 65300 21638 34869985
Depressed mood 19.33 14.44 6 65302 19311 34872312
Gastrointestinal infection 19.29 14.44 37 65271 5761 34885862
Septic arthritis staphylococcal 19.22 14.44 12 65296 504 34891119
Medication error 19.20 14.44 12 65296 25553 34866070
Vertigo 19.16 14.44 12 65296 25524 34866099
Blood pressure increased 19.14 14.44 250 65058 87852 34803771
Intestinal perforation 18.97 14.44 48 65260 9012 34882611
Presyncope 18.93 14.44 6 65302 19053 34872570
Drug tolerance 18.77 14.44 25 65283 2857 34888766
Treatment noncompliance 18.72 14.44 15 65293 28085 34863538
Blood potassium increased 18.66 14.44 4 65304 16491 34875132
Metastatic bronchial carcinoma 18.54 14.44 10 65298 318 34891305
Hypophagia 18.42 14.44 11 65297 24011 34867612
Pulmonary hypertension 18.41 14.44 8 65300 20916 34870707
Bacterial myositis 18.37 14.44 4 65304 4 34891619
Abnormal behaviour 18.37 14.44 12 65296 24957 34866666
Liver function test 18.30 14.44 6 65302 51 34891572
Stevens-Johnson syndrome 18.28 14.44 6 65302 18633 34872990
Excessive cerumen production 18.26 14.44 10 65298 328 34891295
Gastritis 18.26 14.44 9 65299 21864 34869759
Diverticular perforation 18.22 14.44 27 65281 3407 34888216
Pneumonia bacterial 18.05 14.44 56 65252 11816 34879807
Liver injury 18.02 14.44 65 65243 14813 34876810
Ankle operation 17.99 14.44 9 65299 244 34891379
Blood alkaline phosphatase increased 17.97 14.44 19 65289 31156 34860467
Ventricular tachycardia 17.94 14.44 14 65294 26565 34865058
Pneumothorax 17.94 14.44 77 65231 19015 34872608
Adverse drug reaction 17.93 14.44 17 65291 29325 34862298
Long QT syndrome 17.78 14.44 24 65284 2779 34888844
Ulcer 17.66 14.44 46 65262 8789 34882834
Infected dermal cyst 17.44 14.44 14 65294 880 34890743
Hand fracture 17.43 14.44 21 65287 2171 34889452
Hypocalcaemia 17.43 14.44 12 65296 24277 34867346
Clostridium difficile colitis 17.42 14.44 4 65304 15726 34875897
Alveolar proteinosis 17.33 14.44 11 65297 476 34891147
Nightmare 17.31 14.44 3 65305 14388 34877235
Optic nerve operation 17.27 14.44 11 65297 479 34891144
Suture rupture 17.26 14.44 10 65298 366 34891257
Cardiac disorder 17.25 14.44 34 65274 43092 34848531
Solar urticaria 17.19 14.44 5 65303 27 34891596
Nasal crusting 17.14 14.44 10 65298 371 34891252
Neurological examination abnormal 17.13 14.44 9 65299 271 34891352
Haematocrit decreased 17.09 14.44 21 65287 32195 34859428
Nephrolithiasis 17.07 14.44 106 65202 30227 34861396
Circulatory collapse 17.04 14.44 9 65299 21029 34870594
JC virus CSF test positive 17.04 14.44 7 65301 118 34891505
Joint destruction 17.02 14.44 10 65298 376 34891247
Perineal infection 16.89 14.44 12 65296 627 34890996
Scrotal infection 16.65 14.44 12 65296 641 34890982
Full blood count abnormal 16.64 14.44 7 65301 18661 34872962
Gastric perforation 16.63 14.44 22 65286 2498 34889125
Necrotising fasciitis 16.58 14.44 27 65281 3695 34887928
Pollakiuria 16.56 14.44 8 65300 19666 34871957
Investigation abnormal 16.53 14.44 11 65297 516 34891107
Hyperhidrosis 16.45 14.44 79 65229 75613 34816010
Upper respiratory tract infection 16.45 14.44 112 65196 32947 34858676
Rash vesicular 16.44 14.44 23 65285 2754 34888869
Psychotic disorder 16.35 14.44 13 65295 24439 34867184
Flushing 16.30 14.44 22 65286 32398 34859225
Wheezing 16.25 14.44 33 65275 41369 34850254
Squamous cell carcinoma of lung 16.19 14.44 19 65289 1910 34889713
Faeces discoloured 16.05 14.44 4 65304 14874 34876749
Osteoporosis 15.91 14.44 56 65252 12612 34879011
Joint effusion 15.90 14.44 32 65276 5161 34886462
Head injury 15.89 14.44 7 65301 18153 34873470
Anorectal agenesis 15.85 14.44 3 65305 0 34891623
Histoplasmosis cutaneous 15.85 14.44 5 65303 37 34891586
Oesophageal rupture 15.83 14.44 10 65298 429 34891194
Generalised tonic-clonic seizure 15.81 14.44 10 65298 21164 34870459
Myoclonus 15.80 14.44 4 65304 14721 34876902
Full blood count decreased 15.78 14.44 7 65301 18081 34873542
Disseminated cryptococcosis 15.73 14.44 16 65292 1370 34890253
Prostatic specific antigen increased 15.73 14.44 4 65304 14676 34876947
Delirium 15.67 14.44 37 65271 43954 34847669
Speech disorder 15.55 14.44 15 65293 25671 34865952
Blood potassium decreased 15.52 14.44 7 65301 17908 34873715
Blood cholesterol abnormal 15.51 14.44 18 65290 1788 34889835
Diffuse large B-cell lymphoma 15.38 14.44 39 65269 7331 34884292
Cardiomegaly 15.08 14.44 5 65303 15433 34876190
Drug reaction with eosinophilia and systemic symptoms 15.03 14.44 24 65284 32988 34858635
Blood creatine phosphokinase increased 14.99 14.44 39 65269 44818 34846805
Post procedural infection 14.96 14.44 30 65278 4826 34886797
Pneumonia staphylococcal 14.94 14.44 23 65285 3001 34888622
Bradycardia foetal 14.93 14.44 9 65299 355 34891268
Cognitive disorder 14.91 14.44 19 65289 28674 34862949
Listeria encephalitis 14.90 14.44 5 65303 46 34891577
Cerebrovascular accident 14.88 14.44 95 65213 84716 34806907
Fungaemia 14.80 14.44 21 65287 2547 34889076
Rash macular 14.76 14.44 3 65305 12839 34878784
Haemorrhage 14.73 14.44 48 65260 51322 34840301
Scalloped tongue 14.73 14.44 4 65304 16 34891607
Mental disorder 14.73 14.44 5 65303 15204 34876419
Bronchopleural fistula 14.59 14.44 10 65298 493 34891130
Oral herpes 14.45 14.44 32 65276 5515 34886108

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4423.85 13.99 12781 350349 1068132 78313126
Synovitis 3881.99 13.99 4073 359057 146661 79234597
Joint swelling 3831.63 13.99 5583 357547 283063 79098195
Contraindicated product administered 3797.63 13.99 4110 359020 153428 79227830
Drug intolerance 3645.46 13.99 5205 357925 258914 79122344
Treatment failure 2889.29 13.99 3715 359415 166771 79214487
Arthropathy 2693.55 13.99 3660 359470 173451 79207807
Therapeutic product effect decreased 2416.83 13.99 3337 359793 160526 79220732
Arthralgia 1819.23 13.99 6221 356909 565582 78815676
Hand deformity 1685.82 13.99 2218 360912 101701 79279557
Swelling 1650.09 13.99 3277 359853 213434 79167824
Hypersensitivity 1573.65 13.99 3599 359531 258640 79122618
Pemphigus 1557.63 13.99 2088 361042 97494 79283764
Infusion related reaction 1483.21 13.99 3251 359879 226986 79154272
Systemic lupus erythematosus 1468.55 13.99 2250 360880 118899 79262359
Rheumatoid factor positive 1429.75 13.99 1556 361574 58283 79322975
C-reactive protein abnormal 1420.71 13.99 1405 361725 46962 79334296
Anti-cyclic citrullinated peptide antibody positive 1401.77 13.99 1809 361321 81334 79299924
Hepatic enzyme increased 1401.13 13.99 2771 360359 179839 79201419
Toxicity to various agents 1361.32 13.99 162 362968 421378 78959880
Glossodynia 1346.03 13.99 1985 361145 101352 79279906
Pain 1343.67 13.99 6538 356592 697264 78683994
Acute kidney injury 1245.50 13.99 408 362722 518996 78862262
Red blood cell sedimentation rate abnormal 1085.16 13.99 841 362289 20122 79361136
Death 1081.09 13.99 620 362510 565894 78815364
Pericarditis 1072.38 13.99 1797 361333 102439 79278819
Wound 1064.72 13.99 1903 361227 114276 79266982
Peripheral swelling 1052.75 13.99 3152 359978 266465 79114793
Musculoskeletal stiffness 1051.92 13.99 2405 360725 172603 79208655
Drug interaction 1021.75 13.99 311 362819 414872 78966386
Abdominal discomfort 1018.61 13.99 2973 360157 247754 79133504
Anaemia 950.61 13.99 419 362711 444596 78936662
Alopecia 890.73 13.99 2692 360438 228663 79152595
Off label use 867.04 13.99 7061 356069 900154 78481104
Drug hypersensitivity 840.98 13.99 3129 360001 295787 79085471
Helicobacter infection 815.18 13.99 1274 361856 68430 79312828
Duodenal ulcer perforation 776.84 13.99 1212 361918 64999 79316259
Red blood cell sedimentation rate increased 766.69 13.99 995 362135 44947 79336311
Febrile neutropenia 741.90 13.99 90 363040 230909 79150349
Nasopharyngitis 741.04 13.99 2690 360440 251191 79130067
Drug abuse 711.60 13.99 5 363125 162686 79218572
Bone erosion 709.31 13.99 614 362516 17233 79364025
Ill-defined disorder 705.81 13.99 1157 361973 64718 79316540
Impaired healing 697.84 13.99 1352 361778 86303 79294955
Infection 696.85 13.99 2551 360579 239161 79142097
Discomfort 692.93 13.99 1670 361460 123947 79257311
Loss of personal independence in daily activities 684.92 13.99 1471 361659 101109 79280149
Lower respiratory tract infection 674.66 13.99 1682 361448 127538 79253720
Rheumatoid arthritis 666.85 13.99 2277 360853 206193 79175065
Folliculitis 665.36 13.99 1025 362105 54355 79326903
Muscle injury 662.53 13.99 954 362176 47607 79333651
Intentional product use issue 653.09 13.99 1841 361289 150271 79230987
Dehydration 637.51 13.99 171 362959 248016 79133242
Hyponatraemia 629.87 13.99 47 363083 177801 79203457
Sleep disorder due to general medical condition, insomnia type 628.64 13.99 879 362251 42677 79338581
Irritable bowel syndrome 600.15 13.99 1043 362087 61198 79320060
Rash 595.95 13.99 4585 358545 573773 78807485
Sinusitis 555.35 13.99 2054 361076 193447 79187811
Mobility decreased 539.37 13.99 1494 361636 120681 79260577
No adverse event 529.91 13.99 746 362384 36446 79344812
Blister 497.06 13.99 1430 361700 118046 79263212
C-reactive protein increased 481.50 13.99 1486 361644 127541 79253717
Malignant neoplasm progression 472.89 13.99 39 363091 135951 79245307
Maternal exposure during pregnancy 471.54 13.99 1531 361599 135007 79246251
Intentional overdose 464.58 13.99 3 363127 105957 79275301
Weight increased 456.32 13.99 2477 360653 274909 79106349
Rheumatoid nodule 450.69 13.99 473 362657 16965 79364293
Seizure 448.66 13.99 150 362980 188684 79192574
Stomatitis 439.52 13.99 1569 361561 145188 79236070
Product dose omission issue 439.05 13.99 294 362836 247243 79134015
Somnolence 433.13 13.99 277 362853 238704 79142554
Arthritis 428.53 13.99 1323 361807 113557 79267701
Inflammation 417.20 13.99 1150 361980 92603 79288655
Constipation 413.82 13.99 407 362723 282643 79098615
Overdose 412.70 13.99 161 362969 184045 79197213
Dyspnoea 412.32 13.99 2259 360871 854766 78526492
Hyperkalaemia 411.41 13.99 28 363102 114370 79266888
Cardiac failure congestive 399.41 13.99 81 363049 142321 79238937
Fibromyalgia 399.06 13.99 896 362234 63444 79317814
Thrombocytopenia 385.93 13.99 383 362747 264876 79116382
Psoriatic arthropathy 375.44 13.99 985 362145 77014 79304244
Cardiac arrest 373.19 13.99 158 362972 171938 79209320
Knee arthroplasty 369.89 13.99 688 362442 42560 79338698
Rhabdomyolysis 368.66 13.99 26 363104 103105 79278153
Rheumatic fever 368.14 13.99 546 362584 27979 79353279
Hypotension 360.65 13.99 932 362198 439385 78941873
Blood cholesterol increased 349.01 13.99 1003 362127 82717 79298541
Therapeutic product effect incomplete 348.81 13.99 1423 361707 140222 79241036
Bradycardia 348.64 13.99 93 363037 135464 79245794
Joint stiffness 347.27 13.99 648 362482 40182 79341076
Product use issue 339.63 13.99 1866 361264 207956 79173302
Blood pressure diastolic abnormal 339.34 13.99 428 362702 18774 79362484
Gastrointestinal haemorrhage 336.03 13.99 126 363004 147593 79233665
Osteoporosis 329.34 13.99 748 362382 53364 79327894
Coma 325.95 13.99 38 363092 100611 79280647
Atrial fibrillation 324.78 13.99 255 362875 197631 79183627
Hypoglycaemia 322.51 13.99 41 363089 101553 79279705
Renal failure 317.36 13.99 269 362861 200699 79180559
Suicide attempt 314.44 13.99 15 363115 82917 79298341
Pancytopenia 310.08 13.99 185 362945 165560 79215698
Gastrointestinal disorder 309.85 13.99 1239 361891 120966 79260292
Depressed level of consciousness 309.27 13.99 38 363092 96614 79284644
Musculoskeletal pain 308.63 13.99 1097 362033 101257 79280001
Cardio-respiratory arrest 303.69 13.99 62 363068 108448 79272810
Hip arthroplasty 303.50 13.99 567 362563 35189 79346069
Osteoarthritis 303.07 13.99 981 362149 86328 79294930
Diarrhoea 302.94 13.99 2562 360568 877927 78503331
Diverticulitis 297.54 13.99 651 362479 45285 79335973
Skin ulcer 297.34 13.99 719 362411 53431 79327827
Hypokalaemia 293.94 13.99 144 362986 143896 79237362
Cardiac failure 289.42 13.99 173 362957 154669 79226589
Tremor 286.97 13.99 213 362917 169870 79211388
Syncope 286.03 13.99 238 362892 179211 79202047
Tachycardia 278.16 13.99 240 362890 177528 79203730
Coeliac disease 274.07 13.99 297 362833 11054 79370204
Blood parathyroid hormone decreased 272.64 13.99 286 362844 10250 79371008
Blood pressure systolic abnormal 271.34 13.99 363 362767 16884 79364374
Drug eruption 270.33 13.99 610 362520 43325 79337933
Granuloma skin 270.11 13.99 267 362863 8907 79372351
International normalised ratio increased 269.38 13.99 34 363096 84687 79296571
Swollen joint count increased 269.18 13.99 420 362710 22507 79358751
Panniculitis 268.26 13.99 306 362824 12065 79369193
Blood pressure systolic increased 267.13 13.99 790 362340 66196 79315062
Disability assessment scale score increased 267.04 13.99 177 362953 3281 79377977
Asthenia 265.39 13.99 1313 361817 510376 78870882
Electrocardiogram QT prolonged 260.63 13.99 48 363082 90338 79290920
Agitation 259.07 13.99 67 363063 99648 79281610
Inappropriate schedule of product administration 257.27 13.99 144 362986 133484 79247774
Neuropathy peripheral 255.59 13.99 164 362966 141141 79240117
Therapeutic response decreased 254.85 13.99 776 362354 66077 79315181
Decreased appetite 251.81 13.99 763 362367 341655 79039603
Metabolic acidosis 250.89 13.99 38 363092 82491 79298767
Neutropenia 247.78 13.99 593 362537 287117 79094141
Drug tolerance decreased 246.56 13.99 300 362830 12678 79368580
Vomiting 245.76 13.99 1900 361230 663928 78717330
Dizziness 244.55 13.99 1402 361728 525039 78856219
Hallucination 242.00 13.99 48 363082 85697 79295561
Condition aggravated 241.43 13.99 3405 359725 497719 78883539
Cerebrovascular accident 241.31 13.99 211 362919 155081 79226177
Disease progression 239.56 13.99 292 362838 184070 79197188
Foot deformity 239.26 13.99 409 362721 23665 79357593
Injection site pain 235.77 13.99 150 362980 129688 79251570
Bursitis 234.43 13.99 510 362620 35334 79345924
Blood pressure diastolic decreased 232.92 13.99 460 362670 29756 79351502
Lactic acidosis 231.75 13.99 25 363105 70334 79310924
Dysphagia 226.06 13.99 138 362992 121998 79259260
Joint range of motion decreased 225.07 13.99 480 362650 32802 79348456
Fall 220.36 13.99 1310 361820 486319 78894939
Balance disorder 220.34 13.99 87 363043 98770 79282488
Sciatica 218.76 13.99 474 362656 32748 79348510
Adverse event 212.03 13.99 680 362450 59534 79321724
Vision blurred 211.33 13.99 109 363021 105789 79275469
Dysarthria 210.52 13.99 29 363101 67593 79313665
Respiratory failure 210.21 13.99 311 362819 180600 79200658
Pulmonary fibrosis 208.06 13.99 553 362577 43559 79337699
Orthostatic hypotension 207.12 13.99 12 363118 56152 79325106
Anxiety 207.03 13.99 521 362609 247991 79133267
Drug reaction with eosinophilia and systemic symptoms 201.31 13.99 27 363103 64217 79317041
Wrong technique in product usage process 201.00 13.99 45 363085 73830 79307428
Haemoglobin decreased 199.88 13.99 447 362683 221672 79159586
Unresponsive to stimuli 199.54 13.99 14 363116 55774 79325484
Joint destruction 198.18 13.99 185 362945 5740 79375518
Cognitive disorder 197.64 13.99 39 363091 69887 79311371
Nausea 196.36 13.99 3124 360006 954072 78427186
Mental status changes 194.25 13.99 35 363095 66924 79314334
Haematuria 193.28 13.99 39 363091 68797 79312461
Ascites 192.06 13.99 53 363077 75509 79305749
Hyperglycaemia 191.04 13.99 43 363087 70292 79310966
Respiratory arrest 190.69 13.99 20 363110 57530 79323728
Lethargy 190.50 13.99 66 363064 81226 79300032
Coronary artery disease 190.42 13.99 34 363096 65440 79315818
Joint injury 184.94 13.99 428 362702 30907 79350351
Plasma cell myeloma 183.10 13.99 16 363114 53243 79328015
Hypomagnesaemia 182.75 13.99 7 363123 46904 79334354
Blood pressure diastolic increased 179.98 13.99 273 362857 14269 79366989
Type 2 diabetes mellitus 179.69 13.99 621 362509 56501 79324757
Immunodeficiency 177.05 13.99 339 362791 21429 79359829
Disturbance in attention 175.36 13.99 15 363115 50786 79330472
Incorrect dose administered 174.82 13.99 65 363065 76565 79304693
Sedation 174.64 13.99 17 363113 51878 79329380
Pyrexia 173.92 13.99 2117 361013 676592 78704666
Aggression 173.32 13.99 16 363114 50942 79330316
Disorientation 173.30 13.99 37 363093 62739 79318519
Chest discomfort 170.62 13.99 227 362903 137817 79243441
Abdominal pain 170.38 13.99 1057 362073 388512 78992746
Contusion 167.93 13.99 1207 361923 147569 79233689
Mucosal inflammation 167.63 13.99 67 363063 75513 79305745
Skin exfoliation 166.04 13.99 26 363104 55074 79326184
Urticaria 165.77 13.99 1424 361706 183777 79197481
Serotonin syndrome 164.89 13.99 10 363120 45017 79336241
Platelet count decreased 164.51 13.99 405 362725 194259 79186999
Neoplasm progression 163.66 13.99 21 363109 51661 79329597
Ear pain 163.13 13.99 420 362710 32449 79348809
Blood creatinine increased 161.85 13.99 286 362844 154771 79226487
Temperature regulation disorder 158.85 13.99 163 362967 5690 79375568
Deformity 158.56 13.99 207 362923 9398 79371860
Pain in extremity 157.99 13.99 2433 360697 362105 79019153
Pneumonia aspiration 157.55 13.99 54 363076 66913 79314345
Toxic epidermal necrolysis 157.12 13.99 12 363118 44569 79336689
Intentional product misuse 156.85 13.99 122 363008 95043 79286215
Skin necrosis 156.20 13.99 289 362841 17798 79363460
Pleural effusion 156.13 13.99 263 362867 144999 79236259
Apparent death 154.92 13.99 118 363012 2747 79378511
Chronic obstructive pulmonary disease 154.62 13.99 99 363031 85320 79295938
Restlessness 154.44 13.99 16 363114 46476 79334782
Urinary retention 153.04 13.99 35 363095 56595 79324663
COVID-19 152.96 13.99 304 362826 157370 79223888
Rheumatoid factor negative 152.80 13.99 84 363046 1089 79380169
Tenosynovitis 151.60 13.99 262 362868 15292 79365966
Suicidal ideation 150.20 13.99 80 363050 76260 79304998
Acute myocardial infarction 149.71 13.99 82 363048 76954 79304304
Nodule 149.02 13.99 326 362804 22668 79358590
Dyspnoea exertional 148.16 13.99 108 363022 86965 79294293
Depression 148.07 13.99 499 362631 216291 79164967
Haematemesis 148.01 13.99 29 363101 52235 79329023
Jaundice 146.13 13.99 32 363098 53317 79327941
Blood glucose increased 145.22 13.99 186 362944 114789 79266469
Hypophagia 144.71 13.99 18 363112 45349 79335909
Accidental overdose 144.31 13.99 9 363121 39572 79341686
Renal impairment 142.33 13.99 317 362813 157466 79223792
Ulcer 141.60 13.99 376 362754 29596 79351662
Generalised tonic-clonic seizure 141.10 13.99 17 363113 43893 79337365
Investigation abnormal 141.07 13.99 98 363032 1968 79379290
Sepsis 140.16 13.99 690 362440 268738 79112520
Liver injury 139.41 13.99 569 362561 56045 79325213
Pulmonary oedema 139.39 13.99 118 363012 88136 79293122
Heart rate decreased 139.19 13.99 662 362468 69654 79311604
Ventricular tachycardia 137.84 13.99 15 363115 41920 79339338
Dyskinesia 137.49 13.99 20 363110 44753 79336505
Myalgia 136.77 13.99 413 362717 185228 79196030
Blood pressure fluctuation 136.45 13.99 637 362493 66508 79314750
Loss of consciousness 136.02 13.99 357 362773 167586 79213672
Drug withdrawal syndrome 135.86 13.99 5 363125 34713 79346545
Feeling abnormal 134.66 13.99 331 362799 158868 79222390
Oral mucosal exfoliation 134.41 13.99 84 363046 1401 79379857
Hallucination, visual 134.35 13.99 3 363127 32726 79348532
Physical disability 134.14 13.99 115 363015 3183 79378075
Grip strength decreased 133.80 13.99 303 362827 21566 79359692
Tubulointerstitial nephritis 132.77 13.99 11 363119 38224 79343034
Hypoxia 132.50 13.99 165 362965 103078 79278180
Blood bilirubin increased 132.38 13.99 68 363062 66164 79315094
Blood alkaline phosphatase increased 132.35 13.99 62 363068 63602 79317656
Palpitations 131.70 13.99 234 362896 126376 79254882
Diabetic ketoacidosis 129.89 13.99 6 363124 34116 79347142
Limb deformity 129.63 13.99 117 363013 3473 79377785
Pulmonary hypertension 129.36 13.99 30 363100 48050 79333208
Rectal haemorrhage 129.34 13.99 95 363035 76205 79305053
Melaena 128.60 13.99 58 363072 60832 79320426
Food allergy 128.05 13.99 199 362931 10625 79370633
Hepatitis 127.77 13.99 548 362582 55179 79326079
Joint laxity 127.76 13.99 97 363033 2247 79379011
Chest pain 127.50 13.99 758 362372 281546 79099712
Emotional distress 127.14 13.99 16 363114 39953 79341305
Rheumatoid lung 125.81 13.99 124 363006 4121 79377137
Herpes zoster 125.29 13.99 789 362341 92294 79288964
Bone marrow failure 124.11 13.99 39 363091 51068 79330190
Haematochezia 123.39 13.99 130 363000 87515 79293743
Intentional self-injury 122.44 13.99 6 363124 32413 79348845
Angioedema 122.13 13.99 100 363030 75935 79305323
Chronic kidney disease 122.03 13.99 75 363055 66079 79315179
Chills 122.00 13.99 351 362779 159883 79221375
Impaired work ability 121.87 13.99 274 362856 19407 79361851
Oedema peripheral 121.69 13.99 663 362467 251625 79129633
Psychotic disorder 121.48 13.99 21 363109 41381 79339877
Depressed mood 121.35 13.99 35 363095 48445 79332813
Gastrooesophageal reflux disease 121.24 13.99 179 362951 104067 79277191
Drug level increased 121.09 13.99 18 363112 39633 79341625
Blood creatine phosphokinase increased 120.43 13.99 76 363054 66014 79315244
Pulmonary embolism 120.02 13.99 391 362739 171263 79209995
Pneumonia 120.00 13.99 2201 360929 658045 78723213
Ejection fraction decreased 119.92 13.99 10 363120 34567 79346691
Abnormal behaviour 119.78 13.99 13 363117 36408 79344850
Human antichimeric antibody positive 119.52 13.99 81 363049 1560 79379698
Disability 119.32 13.99 250 362880 16870 79364388
Musculoskeletal deformity 118.59 13.99 79 363051 1477 79379781
Product prescribing error 118.52 13.99 29 363101 44784 79336474
Dysgeusia 118.37 13.99 56 363074 57121 79324137
Circulatory collapse 117.61 13.99 16 363114 37652 79343606
Immune effector cell-associated neurotoxicity syndrome 117.34 13.99 139 362991 5709 79375549
Blood sodium decreased 117.05 13.99 9 363121 33246 79348012
Blood pressure decreased 116.45 13.99 170 362960 99296 79281962
Body height below normal 116.43 13.99 87 363043 1966 79379292
Irritability 116.15 13.99 23 363107 41121 79340137
Cholestasis 115.87 13.99 46 363084 52063 79329195
Blood potassium decreased 115.65 13.99 34 363096 46478 79334780
Polyarthritis 115.62 13.99 203 362927 11999 79369259
Blood urea increased 115.36 13.99 39 363091 48751 79332507
Myocardial infarction 113.05 13.99 443 362687 183686 79197572
Red blood cell sedimentation rate 112.86 13.99 133 362997 5432 79375826
Osteonecrosis of jaw 112.34 13.99 29 363101 43197 79338061
Hypervolaemia 112.18 13.99 28 363102 42662 79338596
Flushing 111.25 13.99 143 362987 88125 79293133
Arrhythmia 110.90 13.99 71 363059 61201 79320057
Stevens-Johnson syndrome 110.34 13.99 22 363108 39144 79342114
Joint arthroplasty 110.34 13.99 95 363035 2645 79378613
Sinus tachycardia 109.89 13.99 18 363112 36890 79344368
Upper gastrointestinal haemorrhage 109.01 13.99 27 363103 41353 79339905
Abdominal distension 108.21 13.99 240 362890 119410 79261848
Presyncope 107.74 13.99 27 363103 41027 79340231
Musculoskeletal disorder 107.39 13.99 275 362855 21173 79360085
Transient ischaemic attack 106.97 13.99 53 363077 52642 79328616
Bone cyst 106.84 13.99 103 363027 3330 79377928
Cerebral haemorrhage 105.53 13.99 66 363064 57607 79323651
Full blood count abnormal 105.48 13.99 27 363103 40447 79340811
Haemorrhage 105.43 13.99 157 362973 90961 79290297
Hepatic failure 105.34 13.99 75 363055 61137 79320121
Dysuria 105.32 13.99 50 363080 50901 79330357
Basal cell carcinoma 105.32 13.99 392 362738 36983 79344275
Immobile 103.97 13.99 143 362987 6830 79374428
Lower limb fracture 103.41 13.99 285 362845 22930 79358328
Blood calcium decreased 103.03 13.99 12 363118 31807 79349451
Therapy non-responder 103.02 13.99 747 362383 91558 79289700
Obstructive airways disorder 101.52 13.99 12 363118 31447 79349811
Haemophagocytic lymphohistiocytosis 101.18 13.99 272 362858 21565 79359693
Respiratory distress 101.02 13.99 71 363059 58268 79322990
Gastric disorder 100.84 13.99 387 362743 37046 79344212
Adverse drug reaction 100.31 13.99 580 362550 65812 79315446
Paraesthesia 100.27 13.99 437 362693 175886 79205372
Night sweats 99.87 13.99 486 362644 51609 79329649
Accidental exposure to product 98.51 13.99 13 363117 31309 79349949
Cardiogenic shock 96.53 13.99 35 363095 41879 79339379
Hypofibrinogenaemia 96.42 13.99 77 363053 1925 79379333
Speech disorder 95.95 13.99 65 363065 54380 79326878
Oral herpes 95.68 13.99 309 362821 27145 79354113
Dry skin 94.43 13.99 102 363028 67893 79313365
Electrolyte imbalance 94.35 13.99 14 363116 30867 79350391
Bronchitis chronic 94.03 13.99 109 363021 4373 79376885
Altered state of consciousness 93.70 13.99 41 363089 43781 79337477
Myoclonus 93.23 13.99 9 363121 27651 79353607
Bone density decreased 93.13 13.99 195 362935 13152 79368106
Pericardial effusion 93.11 13.99 47 363083 46190 79335068
Deep vein thrombosis postoperative 93.09 13.99 172 362958 10580 79370678
Gait inability 92.49 13.99 520 362610 58397 79322861
Withdrawal syndrome 92.49 13.99 8 363122 26846 79354412
X-ray abnormal 92.43 13.99 123 363007 5690 79375568
Acute respiratory failure 92.32 13.99 81 363049 59460 79321798
Body temperature decreased 92.12 13.99 339 362791 31806 79349452
Cardiac disorder 92.03 13.99 98 363032 65659 79315599
Prescribed overdose 91.88 13.99 379 362751 37504 79343754
Surgical failure 91.09 13.99 54 363076 815 79380443
Rash macular 90.88 13.99 12 363118 28887 79352371
Haemoptysis 90.74 13.99 73 363057 55926 79325332
Hospitalisation 90.24 13.99 183 362947 94053 79287205
Haemorrhage intracranial 89.68 13.99 8 363122 26185 79355073
Myocardial ischaemia 89.56 13.99 7 363123 25512 79355746
Urinary tract infection 89.29 13.99 809 362321 273703 79107555
Colitis 89.08 13.99 122 363008 73185 79308073
Liver disorder 89.00 13.99 600 362530 71817 79309441
Multiple organ dysfunction syndrome 88.90 13.99 267 362863 119979 79261279
Anti-cyclic citrullinated peptide antibody 88.74 13.99 121 363009 5731 79375527
Visual acuity reduced 88.57 13.99 14 363116 29455 79351803
Nightmare 88.27 13.99 8 363122 25853 79355405
Pollakiuria 87.93 13.99 30 363100 37287 79343971
Inappropriate antidiuretic hormone secretion 87.54 13.99 9 363121 26304 79354954
Mental disorder 87.31 13.99 18 363112 31284 79349974
Joint effusion 87.14 13.99 228 362902 17786 79363472
Aphasia 86.16 13.99 53 363077 46679 79334579
Arthrodesis 86.03 13.99 78 363052 2329 79378929
Ventricular fibrillation 85.73 13.99 20 363110 31906 79349352
Cardiomegaly 85.17 13.99 10 363120 26342 79354916
Respiratory depression 83.33 13.99 13 363117 27617 79353641
Fine motor skill dysfunction 83.11 13.99 112 363018 5245 79376013
Encephalopathy 83.07 13.99 111 363019 67286 79313972
Sleep disorder 82.02 13.99 669 362461 85008 79296250
Onychomycosis 81.62 13.99 140 362990 8121 79373137
Bone pain 81.50 13.99 80 363050 55662 79325596
Dislocation of vertebra 81.10 13.99 136 362994 7744 79373514
Injection site erythema 80.87 13.99 145 362985 78052 79303206
Liver function test increased 80.55 13.99 377 362753 39396 79341862
Pallor 80.19 13.99 66 363064 49996 79331262
Wound infection 79.99 13.99 266 362864 23725 79357533
Treatment noncompliance 79.96 13.99 72 363058 52196 79329062
Subdural haematoma 79.96 13.99 22 363108 31412 79349846
Arthritis bacterial 79.83 13.99 147 362983 9019 79372239
Ataxia 79.70 13.99 10 363120 25029 79356229
Localised infection 79.68 13.99 361 362769 37214 79344044
Drug use disorder 79.48 13.99 142 362988 8509 79372749
Tooth disorder 78.86 13.99 281 362849 25952 79355306
Facet joint syndrome 78.71 13.99 165 362965 11137 79370121
Adjustment disorder with depressed mood 78.23 13.99 145 362985 8941 79372317
Loose body in joint 78.21 13.99 57 363073 1238 79380020
Clostridium difficile colitis 77.74 13.99 25 363105 32258 79349000
Dystonia 77.61 13.99 5 363125 21394 79359864
Lip dry 77.52 13.99 198 362932 15220 79366038
Small intestinal obstruction 77.50 13.99 15 363115 27257 79354001
Muscle rigidity 77.33 13.99 3 363127 19879 79361379
Hypercholesterolaemia 76.94 13.99 256 362874 22839 79358419
Muscle spasticity 76.92 13.99 244 362886 21231 79360027
Intestinal sepsis 76.73 13.99 49 363081 850 79380408
Deep vein thrombosis 76.72 13.99 287 362843 120632 79260626
Intestinal obstruction 76.29 13.99 51 363079 42969 79338289
Hepatic encephalopathy 76.08 13.99 10 363120 24156 79357102
Gastritis 75.98 13.99 64 363066 47929 79333329
Hyperhidrosis 75.84 13.99 393 362737 151099 79230159
Toothache 75.31 13.99 231 362899 19739 79361519
Colitis microscopic 74.76 13.99 157 362973 10611 79370647
Terminal state 74.00 13.99 101 363029 4788 79376470
Diplopia 73.66 13.99 30 363100 33436 79347822
Sinus bradycardia 73.65 13.99 13 363117 25234 79356024
Haematocrit decreased 73.53 13.99 103 363027 61209 79320049
Hemiparesis 73.02 13.99 31 363099 33702 79347556
Neutrophil count decreased 72.83 13.99 204 362926 93755 79287503
Device issue 72.75 13.99 17 363113 27091 79354167
Product administration error 72.65 13.99 27 363103 31819 79349439
Aspiration 72.25 13.99 5 363125 20153 79361105
Blood albumin decreased 71.78 13.99 12 363118 24231 79357027
Mental impairment 70.39 13.99 4 363126 19032 79362226
Exostosis 70.22 13.99 202 362928 16656 79364602
Joint dislocation 69.63 13.99 202 362928 16737 79364521
Cough 69.53 13.99 1213 361917 365576 79015682
Faeces discoloured 69.35 13.99 23 363107 29104 79352154
Drug tolerance 69.19 13.99 134 362996 8541 79372717
Hallucination, auditory 69.04 13.99 7 363123 20686 79360572
Oxygen saturation decreased 68.89 13.99 894 362236 128153 79253105
Femur fracture 68.72 13.99 353 362777 38299 79342959
Gamma-glutamyltransferase increased 68.47 13.99 89 363041 54591 79326667
Presbyacusis 68.45 13.99 72 363058 2588 79378670
Hypophosphataemia 68.39 13.99 6 363124 19907 79361351
Pulmonary arterial hypertension 68.24 13.99 22 363108 28344 79352914
Metastases to bone 68.23 13.99 14 363116 24413 79356845
Anticipatory anxiety 68.23 13.99 51 363079 1153 79380105
Limb mass 68.04 13.99 83 363047 3516 79377742
Lip swelling 67.96 13.99 52 363078 40859 79340399
Tricuspid valve incompetence 67.54 13.99 6 363124 19706 79361552
Acute myeloid leukaemia 67.47 13.99 28 363102 30857 79350401
Frequent bowel movements 67.46 13.99 25 363105 29514 79351744
Mitral valve incompetence 67.24 13.99 23 363107 28542 79352716
Vertigo 67.13 13.99 133 362997 68949 79312309
Mania 67.02 13.99 4 363126 18256 79363002
Infusion site reaction 66.76 13.99 81 363049 3412 79377846
Blood iron abnormal 66.74 13.99 53 363077 1314 79379944
Transplant rejection 66.37 13.99 6 363124 19431 79361827
Coordination abnormal 66.04 13.99 3 363127 17309 79363949
Pharyngitis 65.83 13.99 238 362892 22137 79359121
Glaucoma 65.79 13.99 219 362911 19542 79361716
Hypothermia 65.72 13.99 12 363118 22734 79358524
Delusion 65.38 13.99 8 363122 20415 79360843
Anuria 65.22 13.99 9 363121 20954 79360304
Seronegative arthritis 65.16 13.99 93 363037 4599 79376659
Osteoporotic fracture 64.80 13.99 88 363042 4152 79377106
Obesity 64.70 13.99 324 362806 34801 79346457
Cardiomyopathy 64.63 13.99 25 363105 28749 79352509
Urinary incontinence 64.21 13.99 55 363075 40854 79340404
Tachypnoea 63.95 13.99 33 363097 32030 79349228
Myelodysplastic syndrome 63.76 13.99 29 363101 30272 79350986
Muscle twitching 63.61 13.99 17 363113 24747 79356511
Coagulopathy 63.43 13.99 43 363087 35963 79345295
Agranulocytosis 63.13 13.99 67 363063 44963 79336295
Onychomadesis 62.88 13.99 97 363033 5145 79376113
Parkinsonism 62.85 13.99 3 363127 16581 79364677
Fear 62.67 13.99 12 363118 21974 79359284
Myelosuppression 62.25 13.99 55 363075 40241 79341017
Systemic lupus erythematosus rash 62.06 13.99 58 363072 1802 79379456
Ileus 61.88 13.99 21 363109 26190 79355068
Retinitis 61.59 13.99 100 363030 5543 79375715
Feeling hot 61.56 13.99 111 363019 59623 79321635
Unevaluable event 61.22 13.99 99 363031 55486 79325772
Blood lactate dehydrogenase increased 61.07 13.99 53 363077 39117 79342141
Haemodialysis 61.00 13.99 6 363124 18162 79363096
Nephropathy toxic 60.69 13.99 10 363120 20409 79360849
Clostridium difficile infection 60.42 13.99 63 363067 42622 79338636
Multiple fractures 60.42 13.99 121 363009 7905 79373353
Acute generalised exanthematous pustulosis 59.80 13.99 5 363125 17249 79364009
Dialysis 59.68 13.99 7 363123 18455 79362803
Angina unstable 59.53 13.99 4 363126 16523 79364735
Eczema 59.19 13.99 59 363071 40759 79340499
Hypersomnia 59.02 13.99 16 363114 23070 79358188
Hypovolaemia 58.98 13.99 6 363124 17685 79363573
Metastases to central nervous system 58.87 13.99 4 363126 16371 79364887
Torsade de pointes 58.43 13.99 9 363121 19303 79361955
Blood pressure increased 58.35 13.99 1316 361814 210044 79171214
Leukocytosis 58.35 13.99 67 363063 43388 79337870
Troponin increased 58.20 13.99 9 363121 19246 79362012
Fatigue 58.00 13.99 4949 358181 924778 78456480
Full blood count decreased 57.48 13.99 25 363105 26794 79354464
Hypokinesia 57.41 13.99 9 363121 19051 79362207
Acute coronary syndrome 57.22 13.99 13 363117 21120 79360138
Arteriosclerosis coronary artery 56.99 13.99 7 363123 17809 79363449
Pulmonary toxicity 56.98 13.99 158 362972 12756 79368502
Blood glucose decreased 56.96 13.99 24 363106 26210 79355048
Paranoia 56.69 13.99 10 363120 19422 79361836
Finger deformity 56.65 13.99 113 363017 7361 79373897
Product quality issue 56.56 13.99 43 363087 33897 79347361
Iron deficiency anaemia 56.52 13.99 23 363107 25649 79355609
Hyperlipidaemia 56.44 13.99 24 363106 26069 79355189
Oesophagitis 56.41 13.99 20 363110 24269 79356989
Body temperature increased 56.35 13.99 371 362759 44049 79337209
Angina pectoris 56.16 13.99 93 363037 51639 79329619
Status epilepticus 55.84 13.99 22 363108 25019 79356239
Maternal exposure timing unspecified 55.71 13.99 97 363033 5695 79375563
Glomerular filtration rate decreased 55.70 13.99 17 363113 22685 79358573
Haematoma 55.59 13.99 95 363035 52100 79329158
Eating disorder 55.50 13.99 13 363117 20684 79360574
Autoimmune disorder 55.22 13.99 184 362946 16428 79364830
White blood cell count decreased 55.21 13.99 569 362561 187719 79193539
Brain oedema 55.03 13.99 23 363107 25240 79356018
Retinal toxicity 54.95 13.99 48 363082 1363 79379895
Synovial cyst 54.54 13.99 133 362997 9932 79371326
Alanine aminotransferase abnormal 54.40 13.99 123 363007 8744 79372514
Dermatitis allergic 54.32 13.99 194 362936 17936 79363322
Toxic skin eruption 54.15 13.99 17 363113 22276 79358982
Hyperthyroidism 53.83 13.99 17 363113 22192 79359066
Anal incontinence 53.77 13.99 9 363121 18159 79363099
Ventricular extrasystoles 53.59 13.99 12 363118 19692 79361566
Mesenteritis 53.55 13.99 28 363102 326 79380932
Drug level decreased 53.33 13.99 3 363127 14399 79366859
Flatulence 53.02 13.99 70 363060 42654 79338604
Schizophrenia 52.10 13.99 5 363125 15435 79365823
Atrioventricular block complete 51.98 13.99 7 363123 16603 79364655
Cyanosis 51.60 13.99 25 363105 25157 79356101
White blood cell count increased 51.44 13.99 171 362959 74462 79306796
Rash papular 50.98 13.99 18 363112 21898 79359360
Peripheral venous disease 50.92 13.99 174 362956 15735 79365523
Prothrombin time prolonged 50.85 13.99 8 363122 16891 79364367
Respiratory disorder 50.60 13.99 364 362766 44492 79336766
Antibody test positive 50.55 13.99 63 363067 2729 79378529
Acute hepatic failure 50.37 13.99 38 363092 30075 79351183
Hypocalcaemia 50.35 13.99 94 363036 49830 79331428
Influenza like illness 50.32 13.99 163 362967 71544 79309714
Right ventricular failure 50.21 13.99 22 363108 23475 79357783
Second primary malignancy 50.18 13.99 4 363126 14346 79366912
Memory impairment 49.85 13.99 301 362829 111433 79269825
Delirium 49.76 13.99 207 362923 84420 79296838
Ageusia 49.76 13.99 8 363122 16624 79364634
Head injury 49.76 13.99 58 363072 37311 79343947
Injection site mass 49.73 13.99 15 363115 20169 79361089
Renal disorder 49.23 13.99 72 363058 42033 79339225
Skin reaction 49.05 13.99 173 362957 15895 79365363
Vascular access complication 49.05 13.99 55 363075 2127 79379131
Face oedema 49.03 13.99 34 363096 28102 79353156
Mean platelet volume decreased 48.99 13.99 62 363068 2728 79378530
Renal injury 48.76 13.99 9 363121 16918 79364340
Epilepsy 48.64 13.99 69 363061 40791 79340467
Red cell distribution width decreased 48.63 13.99 53 363077 1985 79379273
Supraventricular tachycardia 48.57 13.99 18 363112 21252 79360006
Pleural fibrosis 48.44 13.99 76 363054 4091 79377167
Left ventricular dysfunction 48.41 13.99 14 363116 19347 79361911
Mood altered 48.28 13.99 11 363119 17836 79363422
Pancreatitis 48.04 13.99 156 362974 68419 79312839
Lower respiratory tract congestion 48.00 13.99 74 363056 3923 79377335
Pulmonary thrombosis 47.98 13.99 143 362987 12028 79369230
Cutaneous vasculitis 47.90 13.99 112 363018 8140 79373118
Joint lock 47.87 13.99 66 363064 3159 79378099
Myopathy 47.64 13.99 17 363113 20546 79360712
Shock 47.54 13.99 78 363052 43470 79337788
Pneumonia viral 47.49 13.99 119 363011 9039 79372219
Device dislocation 47.12 13.99 30 363100 25940 79355318
Metastases to liver 47.02 13.99 36 363094 28278 79352980
Wrist deformity 46.97 13.99 53 363077 2064 79379194
Salivary hypersecretion 46.97 13.99 5 363125 14219 79367039
Atrial flutter 46.60 13.99 20 363110 21605 79359653
Nail disorder 46.48 13.99 139 362991 11713 79369545
Injection site swelling 46.43 13.99 90 363040 47042 79334216
Blood lactic acid increased 46.15 13.99 3 363127 12741 79368517
Eosinophilia 46.06 13.99 85 363045 45260 79335998
Lymphocyte count decreased 45.98 13.99 91 363039 47198 79334060
Pleural thickening 45.74 13.99 62 363068 2920 79378338
Paraesthesia oral 45.62 13.99 18 363112 20453 79360805
Drug specific antibody 45.51 13.99 58 363072 2570 79378688
Pruritus allergic 45.48 13.99 43 363087 1356 79379902
Graft versus host disease 45.47 13.99 7 363123 15019 79366239
Nervousness 45.43 13.99 51 363079 33364 79347894
Spinal column injury 45.35 13.99 53 363077 2145 79379113
Hemiplegia 45.11 13.99 7 363123 14932 79366326
Malnutrition 45.11 13.99 23 363107 22479 79358779
Coronary artery stenosis 45.03 13.99 3 363127 12481 79368777
Sinus disorder 44.98 13.99 23 363107 22441 79358817
Skin papilloma 44.62 13.99 89 363041 5797 79375461
Activated partial thromboplastin time prolonged 44.52 13.99 6 363124 14222 79367036
Wheelchair user 44.44 13.99 91 363039 6041 79375217
Joint ankylosis 44.04 13.99 52 363078 2128 79379130
Electrocardiogram abnormal 43.93 13.99 11 363119 16726 79364532
End stage renal disease 43.89 13.99 3 363127 12217 79369041
Hypoalbuminaemia 43.86 13.99 21 363109 21276 79359982
Atrioventricular block 43.75 13.99 6 363124 14035 79367223
Chromaturia 43.70 13.99 32 363098 25714 79355544
Lung infiltration 43.62 13.99 25 363105 22887 79358371
Juvenile idiopathic arthritis 43.53 13.99 78 363052 4685 79376573
Eye swelling 43.51 13.99 34 363096 26434 79354824
Cerebral infarction 43.46 13.99 89 363041 45587 79335671
Demyelination 43.45 13.99 106 363024 7917 79373341
Cardiac failure acute 43.26 13.99 16 363114 18913 79362345
Polyuria 43.21 13.99 8 363122 15006 79366252
Haematotoxicity 43.13 13.99 9 363121 15510 79365748
Dementia 42.70 13.99 30 363100 24629 79356629
Concomitant disease aggravated 42.54 13.99 5 363125 13162 79368096
Caesarean section 42.45 13.99 4 363126 12531 79368727
Viral upper respiratory tract infection 42.39 13.99 113 363017 8913 79372345
Device occlusion 42.36 13.99 3 363127 11863 79369395
Arteriosclerosis 42.34 13.99 15 363115 18212 79363046
Failure to thrive 42.27 13.99 3 363127 11841 79369417
Atrioventricular block first degree 42.27 13.99 4 363126 12487 79368771
Pneumonitis 42.25 13.99 139 362991 60721 79320537
Tooth infection 42.24 13.99 184 362946 18648 79362610
Soft tissue disorder 42.10 13.99 65 363065 3450 79377808
Peripheral sensory neuropathy 41.98 13.99 5 363125 13028 79368230
Laryngitis 41.71 13.99 164 362966 15875 79365383
Bone swelling 41.64 13.99 45 363085 1669 79379589
Hypotonia 41.30 13.99 5 363125 12865 79368393
Bedridden 41.23 13.99 135 362995 11944 79369314
Glycosylated haemoglobin increased 41.21 13.99 18 363112 19242 79362016
Blood magnesium decreased 41.17 13.99 12 363118 16500 79364758
Diverticular perforation 41.00 13.99 86 363044 5807 79375451
Blood uric acid increased 40.94 13.99 6 363124 13354 79367904
Haemolytic anaemia 40.83 13.99 15 363115 17805 79363453
Hepatitis cholestatic 40.69 13.99 7 363123 13845 79367413
Ischaemic stroke 40.38 13.99 55 363075 33076 79348182
Injection site warmth 40.31 13.99 9 363121 14798 79366460
Incorrect product administration duration 40.28 13.99 4 363126 12018 79369240
Injection site reaction 40.26 13.99 404 362726 54381 79326877
Cytology abnormal 40.24 13.99 23 363107 323 79380935
Renal tubular necrosis 40.11 13.99 33 363097 25006 79356252
Progressive multifocal leukoencephalopathy 39.91 13.99 22 363108 20578 79360680
Vaginal haemorrhage 39.86 13.99 25 363105 21792 79359466
Prostate cancer 39.77 13.99 56 363074 33212 79348046
Pain of skin 39.54 13.99 9 363121 14604 79366654
Foot fracture 39.24 13.99 201 362929 21780 79359478
Enthesopathy 38.96 13.99 129 363001 11479 79369779
Pancreatitis acute 38.95 13.99 107 363023 49497 79331761
Infected bite 38.93 13.99 46 363084 1884 79379374
Thirst 38.90 13.99 18 363112 18601 79362657
Atelectasis 38.86 13.99 54 363076 32203 79349055
Eyelid ptosis 38.84 13.99 3 363127 11041 79370217
Metastases to lung 38.82 13.99 17 363113 18146 79363112
Neutrophil count increased 38.74 13.99 46 363084 29350 79351908
Device malfunction 38.61 13.99 25 363105 21423 79359835
Pathogen resistance 38.48 13.99 9 363121 14333 79366925
Thrombotic microangiopathy 38.41 13.99 22 363108 20147 79361111
Faecaloma 38.35 13.99 4 363126 11560 79369698
Skin burning sensation 38.35 13.99 7 363123 13265 79367993
Urine output decreased 38.31 13.99 17 363113 18005 79363253
Bundle branch block left 38.14 13.99 4 363126 11509 79369749
Posterior reversible encephalopathy syndrome 38.09 13.99 38 363092 26243 79355015
Blood magnesium increased 38.09 13.99 62 363068 3444 79377814
Pulmonary haemorrhage 38.00 13.99 10 363120 14707 79366551
Toxic encephalopathy 37.83 13.99 4 363126 11436 79369822
C-reactive protein 37.40 13.99 75 363055 4904 79376354
Hypercalcaemia 37.26 13.99 301 362829 38129 79343129
Polyneuropathy 37.26 13.99 33 363097 24118 79357140
Hepatitis B virus test positive 37.23 13.99 25 363105 474 79380784
Staphylococcal infection 37.20 13.99 138 362992 58157 79323101
Pruritus 37.02 13.99 2173 360957 392475 78988783
Congestive cardiomyopathy 36.78 13.99 5 363125 11775 79369483
Escherichia infection 36.75 13.99 18 363112 17999 79363259
Cardiac failure chronic 36.55 13.99 4 363126 11131 79370127
Confusional state 36.47 13.99 1136 361994 316861 79064397
Hepatocellular injury 36.38 13.99 104 363026 47489 79333769
Blood fibrinogen decreased 36.38 13.99 45 363085 1934 79379324
Adverse reaction 36.30 13.99 109 363021 9205 79372053
Therapeutic response unexpected 36.24 13.99 23 363107 19923 79361335
Prostatic specific antigen increased 36.02 13.99 3 363127 10383 79370875
Live birth 36.01 13.99 175 362955 18569 79362689
Poor venous access 35.99 13.99 171 362959 17978 79363280
Prescribed underdose 35.93 13.99 244 362886 29270 79351988
Infiltration anaesthesia 35.91 13.99 17 363113 157 79381101
Incontinence 35.86 13.99 10 363120 14154 79367104
Hospice care 35.76 13.99 3 363127 10321 79370937
Injection site hypersensitivity 35.75 13.99 44 363086 1881 79379377
Bone disorder 35.69 13.99 177 362953 18936 79362322
Gastric haemorrhage 35.63 13.99 12 363118 15038 79366220
Blood loss anaemia 35.59 13.99 13 363117 15485 79365773
Squamous cell carcinoma of skin 35.36 13.99 10 363120 14023 79367235
Hyperthermia 35.33 13.99 19 363111 18018 79363240
Dermatitis exfoliative 35.27 13.99 4 363126 10825 79370433
Ankle arthroplasty 35.25 13.99 39 363091 1486 79379772
Personality change 35.10 13.99 3 363127 10167 79371091
Transaminases abnormal 34.94 13.99 30 363100 832 79380426
Bronchospasm 34.83 13.99 37 363093 24822 79356436
Purpura 34.82 13.99 23 363107 19504 79361754
Lupus-like syndrome 34.68 13.99 140 362990 13717 79367541
Dermatitis atopic 34.62 13.99 3 363127 10053 79371205
Acute pulmonary oedema 34.30 13.99 11 363119 14219 79367039
Anger 33.73 13.99 18 363112 17144 79364114
Oliguria 33.71 13.99 16 363114 16293 79364965
Dizziness postural 33.57 13.99 6 363124 11543 79369715
Retching 33.34 13.99 19 363111 17448 79363810
Nephropathy 33.27 13.99 3 363127 9735 79371523
Coronary artery occlusion 33.26 13.99 14 363116 15301 79365957
Pemphigoid 33.26 13.99 14 363116 15301 79365957
Sudden death 33.26 13.99 32 363098 22479 79358779
Tongue disorder 33.24 13.99 139 362991 13836 79367422
Eructation 33.20 13.99 5 363125 10904 79370354
Hepatic cytolysis 33.16 13.99 45 363085 27106 79354152
Haemodynamic instability 33.05 13.99 19 363111 17363 79363895
Abortion spontaneous 33.01 13.99 52 363078 29455 79351803
Device leakage 32.98 13.99 5 363125 10851 79370407
Hepatitis C 32.97 13.99 7 363123 11918 79369340
Interstitial lung disease 32.92 13.99 707 362423 111893 79269365
Electrocardiogram QRS complex prolonged 32.89 13.99 5 363125 10828 79370430
Device difficult to use 32.88 13.99 10 363120 13375 79367883
Muscular weakness 32.87 13.99 524 362606 160205 79221053
Sleep disorder due to a general medical condition 32.74 13.99 12 363118 14265 79366993
Odynophagia 32.67 13.99 6 363124 11321 79369937
Skin laceration 32.65 13.99 235 362895 28727 79352531
Rales 32.49 13.99 26 363104 19975 79361283
Device related infection 32.48 13.99 67 363063 34227 79347031
Bunion operation 32.37 13.99 30 363100 922 79380336
Respiratory acidosis 32.16 13.99 6 363124 11194 79370064
Deafness 32.15 13.99 29 363101 21008 79360250
Proteinuria 32.07 13.99 62 363068 32440 79348818
Deafness neurosensory 32.03 13.99 86 363044 6812 79374446
Complication associated with device 32.03 13.99 20 363110 17476 79363782
Thermal burn 31.98 13.99 88 363042 7072 79374186
Drug specific antibody present 31.97 13.99 84 363046 6568 79374690
Haemorrhoids 31.96 13.99 52 363078 29076 79352182
Mean cell volume decreased 31.90 13.99 70 363060 4877 79376381
Respiratory syncytial virus infection 31.84 13.99 3 363127 9399 79371859
Drug resistance 31.71 13.99 93 363037 42120 79339138
Tinnitus 31.64 13.99 100 363030 44233 79337025
Hypothyroidism 31.52 13.99 127 363003 52265 79328993
Cholecystitis chronic 31.42 13.99 4 363126 9902 79371356
Nystagmus 31.41 13.99 4 363126 9900 79371358
Multiple sclerosis 31.41 13.99 33 363097 22249 79359009
Vasculitic rash 31.38 13.99 44 363086 2140 79379118
Squamous cell carcinoma 31.27 13.99 16 363114 15606 79365652
Red blood cell count decreased 31.19 13.99 145 362985 57368 79323890
Immune reconstitution inflammatory syndrome 31.13 13.99 12 363118 13829 79367429
Swollen tongue 31.11 13.99 95 363035 42475 79338783
Cold sweat 30.76 13.99 24 363106 18675 79362583
Rash maculo-papular 30.64 13.99 141 362989 55937 79325321
Hyperuricaemia 30.50 13.99 8 363122 11791 79369467
Immune thrombocytopenia 30.39 13.99 22 363108 17783 79363475
Generalised oedema 30.29 13.99 38 363092 23671 79357587
Muscle atrophy 30.23 13.99 7 363123 11225 79370033
Asphyxia 30.19 13.99 8 363122 11712 79369546
Neck pain 30.16 13.99 497 362633 74920 79306338
Cerebral ischaemia 30.08 13.99 7 363123 11188 79370070
Left ventricular hypertrophy 30.07 13.99 7 363123 11184 79370074
Malignant melanoma 30.04 13.99 140 362990 14601 79366657
Prosthesis user 30.01 13.99 12 363118 70 79381188
Dysstasia 30.00 13.99 50 363080 27696 79353562
Injury 30 13.99 508 362622 76988 79304270
Orthopnoea 29.79 13.99 5 363125 10068 79371190
Myocarditis 29.73 13.99 33 363097 21700 79359558
Extremity contracture 29.64 13.99 38 363092 1694 79379564
Lupus vulgaris 29.56 13.99 54 363076 3292 79377966
Anosmia 29.48 13.99 3 363127 8841 79372417
Subarachnoid haemorrhage 29.43 13.99 41 363089 24424 79356834
Intervertebral disc compression 29.29 13.99 33 363097 1283 79379975
Mass 29.29 13.99 157 362973 17315 79363943
Hypoaesthesia oral 28.97 13.99 14 363116 14110 79367148
Tumour lysis syndrome 28.91 13.99 40 363090 23899 79357359
Neoscytalidium infection 28.73 13.99 8 363122 10 79381248
Therapy interrupted 28.53 13.99 242 362888 31099 79350159
Osteonecrosis 28.40 13.99 62 363068 31033 79350225
Skin discolouration 28.29 13.99 94 363036 40940 79340318
Intestinal polyp 28.19 13.99 41 363089 2063 79379195
Cytokine storm 28.15 13.99 29 363101 1017 79380241
Dermatitis bullous 27.91 13.99 15 363115 14230 79367028
Central nervous system lesion 27.81 13.99 13 363117 13355 79367903
Immunosuppressant drug level increased 27.79 13.99 4 363126 9023 79372235
Hyperammonaemia 27.77 13.99 8 363122 11085 79370173
Panic attack 27.74 13.99 42 363088 24174 79357084
Breast cancer stage III 27.63 13.99 103 363027 9723 79371535
Electrocardiogram ST segment elevation 27.60 13.99 3 363127 8394 79372864
Haemorrhagic stroke 27.59 13.99 8 363122 11038 79370220
Brain injury 27.58 13.99 9 363121 11508 79369750
Abnormal loss of weight 27.52 13.99 3 363127 8373 79372885
Post transplant lymphoproliferative disorder 27.39 13.99 9 363121 11455 79369803
Breast cancer female 27.37 13.99 9 363121 11452 79369806
Brachiocephalic artery stenosis 27.21 13.99 9 363121 27 79381231
Foot operation 27.15 13.99 72 363058 5661 79375597
Injection site pruritus 27.04 13.99 100 363030 42183 79339075
Autoimmune hepatitis 26.86 13.99 10 363120 11773 79369485
Splenomegaly 26.79 13.99 33 363097 20721 79360537
Catatonia 26.68 13.99 4 363126 8752 79372506
Fracture delayed union 26.66 13.99 40 363090 2070 79379188
Cytomegalovirus infection 26.53 13.99 102 363028 42542 79338716
Procedural pain 26.48 13.99 40 363090 23044 79358214
Tuberculin test positive 26.40 13.99 52 363078 3356 79377902
Hepatic enzyme abnormal 26.40 13.99 87 363043 7723 79373535
Erythema multiforme 26.19 13.99 25 363105 17626 79363632
Post procedural haemorrhage 26.16 13.99 15 363115 13729 79367529
Lower gastrointestinal haemorrhage 26.14 13.99 21 363109 16104 79365154
Eye movement disorder 25.99 13.99 3 363127 8008 79373250
Ileus paralytic 25.88 13.99 6 363124 9614 79371644
Epigastric discomfort 25.83 13.99 87 363043 7809 79373449
Shock haemorrhagic 25.79 13.99 32 363098 20028 79361230
Dermatitis contact 25.77 13.99 9 363121 11024 79370234
Post procedural complication 25.71 13.99 43 363087 23786 79357472
Pulmonary alveolar haemorrhage 25.65 13.99 10 363120 11447 79369811
Oral candidiasis 25.50 13.99 61 363069 29567 79351691
Refusal of treatment by patient 25.43 13.99 5 363125 8986 79372272
Mean cell haemoglobin decreased 25.36 13.99 74 363056 6150 79375108
Back injury 25.29 13.99 105 363025 10418 79370840
Infusion site erythema 25.25 13.99 6 363124 9454 79371804
Muscle spasms 25.25 13.99 604 362526 174126 79207132
Product label confusion 25.23 13.99 34 363096 1592 79379666
Eye pruritus 25.22 13.99 34 363096 20536 79360722
Infusion site swelling 25.21 13.99 3 363127 7823 79373435
Hyperreflexia 25.16 13.99 4 363126 8381 79372877
Aplasia pure red cell 25.15 13.99 3 363127 7807 79373451
Aortic arteriosclerosis 25.14 13.99 5 363125 8913 79372345
Nervous system disorder 24.99 13.99 53 363077 26803 79354455
Bundle branch block right 24.90 13.99 10 363120 11241 79370017
Hyperbilirubinaemia 24.87 13.99 46 363084 24472 79356786
Lipase increased 24.81 13.99 23 363107 16443 79364815
Normochromic normocytic anaemia 24.80 13.99 3 363127 7724 79373534
Amylase increased 24.74 13.99 10 363120 11199 79370059
Gynaecomastia 24.61 13.99 3 363127 7678 79373580
Lymphocyte adoptive therapy 24.61 13.99 7 363123 10 79381248
Torus fracture 24.38 13.99 11 363119 90 79381168
Ear infection 24.38 13.99 252 362878 34180 79347078
Swelling face 24.38 13.99 207 362923 71005 79310253
Cyst 24.32 13.99 126 363004 13714 79367544
Allergy to chemicals 24.28 13.99 43 363087 2559 79378699
Rheumatic disorder 24.24 13.99 48 363082 3110 79378148
Paralysis 24.21 13.99 15 363115 13162 79368096
Petechiae 24.21 13.99 35 363095 20530 79360728
Dental restoration failure 24.20 13.99 26 363104 958 79380300
Gastric infection 24.08 13.99 53 363077 3700 79377558
Multiple allergies 24.07 13.99 103 363027 10357 79370901
Protein urine present 24.05 13.99 8 363122 10104 79371154
Metabolic encephalopathy 24.03 13.99 6 363124 9141 79372117
Acidosis 23.89 13.99 33 363097 19729 79361529
Tendonitis 23.84 13.99 188 362942 23642 79357616
Gout 23.74 13.99 48 363082 24701 79356557
Exercise tolerance decreased 23.73 13.99 6 363124 9065 79372193
Hypoacusis 23.70 13.99 65 363065 30085 79351173
Colitis ulcerative 23.66 13.99 80 363050 34662 79346596
Blood triglycerides increased 23.61 13.99 37 363093 21003 79360255
Throat tightness 23.59 13.99 58 363072 27849 79353409
Hepatocellular carcinoma 23.54 13.99 6 363124 9015 79372243
Cytokine release syndrome 23.41 13.99 259 362871 35739 79345519
Cerebral haematoma 23.36 13.99 4 363126 7938 79373320
Blood creatine increased 23.34 13.99 7 363123 9448 79371810
Urosepsis 23.25 13.99 54 363076 26441 79354817
Eyelid oedema 23.24 13.99 17 363113 13670 79367588
Periorbital oedema 23.09 13.99 5 363125 8397 79372861
Limb discomfort 23.06 13.99 240 362890 32610 79348648
Nephrotic syndrome 23.04 13.99 11 363119 11163 79370095
Iron deficiency 22.72 13.99 10 363120 10644 79370614
Cachexia 22.71 13.99 11 363119 11072 79370186
Thyroid disorder 22.58 13.99 125 363005 13954 79367304
Smear cervix abnormal 22.50 13.99 41 363089 2495 79378763
Duodenal ulcer haemorrhage 22.46 13.99 3 363127 7160 79374098
Blood glucose abnormal 22.41 13.99 10 363120 10556 79370702
Eosinophil count increased 22.29 13.99 27 363103 17078 79364180
Metabolic disorder 22.26 13.99 7 363123 9163 79372095
Duodenal ulcer 22.23 13.99 25 363105 16344 79364914
Carotid artery occlusion 22.17 13.99 4 363126 7643 79373615
Nasal ulcer 22.11 13.99 37 363093 2103 79379155
Injection site inflammation 22.03 13.99 53 363077 3923 79377335
Peritonitis bacterial 22.01 13.99 8 363122 9559 79371699
Diabetic eye disease 22.00 13.99 12 363118 153 79381105
Appendicitis 22.00 13.99 38 363092 20756 79360502
Androgenetic alopecia 21.80 13.99 12 363118 156 79381102
Hepatic cirrhosis 21.73 13.99 249 362881 34657 79346601
Hypertension 21.61 13.99 1769 361361 329223 79052035
Sleep apnoea syndrome 21.58 13.99 89 363041 36389 79344869
Ventricular hypertrophy 21.53 13.99 3 363127 6935 79374323
Partial seizures 21.53 13.99 7 363123 8971 79372287
Stress cardiomyopathy 21.52 13.99 12 363118 11154 79370104
Vaginal discharge 21.43 13.99 4 363126 7459 79373799
Vascular rupture 21.37 13.99 32 363098 1653 79379605
Hypercapnia 21.37 13.99 7 363123 8928 79372330
Short stature 21.35 13.99 21 363109 696 79380562
Mood swings 21.33 13.99 36 363094 19844 79361414
Bladder cancer 21.29 13.99 35 363095 19491 79361767
Premature delivery 21.26 13.99 47 363083 23420 79357838
Extrasystoles 21.25 13.99 4 363126 7415 79373843
Nerve injury 21.24 13.99 92 363038 9300 79371958
Ligament sprain 21.23 13.99 119 363011 13345 79367913
Bladder transitional cell carcinoma 21.22 13.99 41 363089 2609 79378649
Needle issue 21.21 13.99 17 363113 13051 79368207
Intestinal perforation 21.17 13.99 144 362986 17282 79363976
Gastric ulcer 21.15 13.99 81 363049 33824 79347434
Walking aid user 21.14 13.99 97 363033 10051 79371207
Hiatus hernia 20.87 13.99 47 363083 23265 79357993
Diabetes mellitus inadequate control 20.85 13.99 50 363080 24214 79357044
Hypernatraemia 20.82 13.99 21 363109 14430 79366828
Embolic stroke 20.82 13.99 5 363125 7821 79373437
Interleukin level increased 20.63 13.99 19 363111 579 79380679
Breast cancer stage I 20.55 13.99 3 363127 6697 79374561
Paranasal sinus inflammation 20.53 13.99 13 363117 222 79381036
Injection site haemorrhage 20.50 13.99 62 363068 27808 79353450
Decreased activity 20.46 13.99 7 363123 8687 79372571
Retinal haemorrhage 20.44 13.99 6 363124 8211 79373047
Blood pressure abnormal 20.43 13.99 29 363101 17140 79364118
Blood phosphorus decreased 20.42 13.99 3 363127 6665 79374593
Tension headache 20.42 13.99 4 363126 7207 79374051
Proctalgia 20.38 13.99 10 363120 9991 79371267
Metastases to lymph nodes 20.29 13.99 11 363119 10386 79370872
Thinking abnormal 20.28 13.99 18 363112 13143 79368115
Ammonia increased 20.07 13.99 5 363125 7630 79373628
Escherichia urinary tract infection 20.02 13.99 20 363110 13805 79367453
Glucose tolerance impaired 19.93 13.99 6 363124 8078 79373180
Fear of injection 19.90 13.99 77 363053 7397 79373861
Cerebral atrophy 19.90 13.99 6 363124 8069 79373189
Defaecation disorder 19.89 13.99 20 363110 681 79380577
Vascular device infection 19.87 13.99 11 363119 10265 79370993
Device breakage 19.83 13.99 12 363118 10663 79370595
Abnormal faeces 19.82 13.99 5 363125 7566 79373692
Urine analysis abnormal 19.81 13.99 3 363127 6517 79374741
Systemic inflammatory response syndrome 19.78 13.99 14 363116 11451 79369807
Arthropod sting 19.77 13.99 27 363103 1281 79379977
Granulocytopenia 19.67 13.99 14 363116 11417 79369841
Thiopurine methyltransferase decreased 19.63 13.99 15 363115 351 79380907
Lung disorder 19.59 13.99 493 362637 80064 79301194
Lymphadenopathy 19.50 13.99 152 362978 53095 79328163
Arthritis infective 19.47 13.99 82 363048 8189 79373069
Proctitis 19.45 13.99 3 363127 6429 79374829
Localised oedema 19.43 13.99 6 363124 7946 79373312
Hepatic lesion 19.41 13.99 4 363126 6955 79374303
Myositis 19.41 13.99 36 363094 19132 79362126
Productive cough 19.40 13.99 284 362846 88047 79293211
Premature labour 19.33 13.99 7 363123 8383 79372875
Radiculopathy 19.27 13.99 8 363122 8816 79372442
Thrombotic thrombocytopenic purpura 19.23 13.99 3 363127 6373 79374885
Colitis ischaemic 19.22 13.99 25 363105 15334 79365924
Intercepted product storage error 19.20 13.99 13 363117 250 79381008
Rash pruritic 19.12 13.99 444 362686 71185 79310073
Malaise 19.11 13.99 1946 361184 487923 78893335
Blood urine present 19.01 13.99 43 363087 21254 79360004
Cholelithiasis 18.98 13.99 151 362979 52513 79328745
Hypoxic-ischaemic encephalopathy 18.93 13.99 6 363124 7814 79373444
Skin hyperpigmentation 18.78 13.99 5 363125 7298 79373960
Respiratory tract infection 18.77 13.99 137 362993 48552 79332706
Adenoiditis 18.72 13.99 7 363123 33 79381225
Protein total decreased 18.67 13.99 9 363121 9083 79372175
Therapeutic response shortened 18.67 13.99 27 363103 15836 79365422
Poor quality sleep 18.61 13.99 48 363082 22674 79358584
Disease recurrence 18.54 13.99 121 363009 43988 79337270
Arteriospasm coronary 18.45 13.99 4 363126 6712 79374546
Hereditary motor and sensory neuropathy 18.37 13.99 10 363120 127 79381131
Illness 18.35 13.99 130 363000 46381 79334877
Injection site induration 18.29 13.99 11 363119 9808 79371450
Sebaceous gland infection 18.27 13.99 11 363119 171 79381087
Amyotrophic lateral sclerosis 18.25 13.99 31 363099 1784 79379474
Neurotoxicity 18.22 13.99 81 363049 32437 79348821
Gastropleural fistula 18.21 13.99 8 363122 61 79381197
Injection site hyperaesthesia 18.21 13.99 8 363122 61 79381197
Neck surgery 18.20 13.99 31 363099 1788 79379470
Lung consolidation 18.15 13.99 9 363121 8938 79372320
Viral infection 18.08 13.99 118 363012 42898 79338360
Injection site urticaria 18.07 13.99 19 363111 12807 79368451
Disability assessment scale score decreased 18.07 13.99 5 363125 6 79381252
Tongue oedema 18.07 13.99 5 363125 7112 79374146
Apnoea 18.05 13.99 16 363114 11688 79369570
Vaginal haematoma 18.03 13.99 10 363120 132 79381126
Tympanic membrane perforation 17.99 13.99 30 363100 1700 79379558
Normal newborn 17.89 13.99 5 363125 7067 79374191
Hepatomegaly 17.77 13.99 37 363093 18837 79362421
Rhinovirus infection 17.71 13.99 7 363123 7946 79373312
Infectious pleural effusion 17.71 13.99 47 363083 3697 79377561
Bladder prolapse 17.67 13.99 27 363103 1420 79379838
Varices oesophageal 17.66 13.99 3 363127 5988 79375270
Bacteraemia 17.65 13.99 83 363047 32741 79348517
Oesophageal candidiasis 17.63 13.99 10 363120 9208 79372050
Female genital tract fistula 17.59 13.99 3 363127 5972 79375286
Blood potassium increased 17.59 13.99 71 363059 29204 79352054
Pulmonary mass 17.58 13.99 206 362924 28828 79352430
Disseminated large cell lymphoma 17.57 13.99 8 363122 67 79381191
Oesophageal ulcer 17.52 13.99 5 363125 6970 79374288
Hepatitis B 17.49 13.99 8 363122 8324 79372934
Cystitis haemorrhagic 17.47 13.99 10 363120 9162 79372096
Sensory loss 17.47 13.99 20 363110 12971 79368287
Affective disorder 17.44 13.99 8 363122 8311 79372947
Therapy cessation 17.38 13.99 100 363030 37462 79343796
Epistaxis 17.37 13.99 381 362749 111134 79270124
Wrist surgery 17.36 13.99 20 363110 797 79380461
Impaired gastric emptying 17.33 13.99 93 363037 10260 79370998
Fistula 17.32 13.99 20 363110 12920 79368338
Blood disorder 17.28 13.99 8 363122 8265 79372993
Oesophageal carcinoma 17.27 13.99 15 363115 11069 79370189
Blood immunoglobulin E increased 17.22 13.99 3 363127 5879 79375379
Mycotic endophthalmitis 17.22 13.99 11 363119 191 79381067
Occult blood positive 17.17 13.99 5 363125 6878 79374380
Metastasis 17.16 13.99 5 363125 6875 79374383
Ulcerative keratitis 17.14 13.99 46 363084 3643 79377615
Injection site rash 17.07 13.99 35 363095 17919 79363339
Enteritis 16.99 13.99 25 363105 14558 79366700
Defaecation urgency 16.98 13.99 3 363127 5821 79375437
Pregnancy 16.92 13.99 192 362938 26659 79354599
Major depression 16.81 13.99 10 363120 8970 79372288
Anal fissure 16.80 13.99 7 363123 7696 79373562
Swollen joint count 16.75 13.99 24 363106 1191 79380067
Genital haemorrhage 16.63 13.99 4 363126 6251 79375007
Insurance issue 16.62 13.99 3 363127 5730 79375528
Petit mal epilepsy 16.59 13.99 3 363127 5724 79375534
Pulmonary function test decreased 16.56 13.99 7 363123 7630 79373628
Hydrocephalus 16.54 13.99 10 363120 8890 79372368
Infected varicose vein 16.45 13.99 6 363124 26 79381232
Cardiac tamponade 16.44 13.99 11 363119 9265 79371993
Micturition urgency 16.42 13.99 20 363110 12621 79368637
Hypovolaemic shock 16.40 13.99 19 363111 12257 79369001
Oropharyngeal pain 16.40 13.99 631 362499 108722 79272536
Brain death 16.39 13.99 3 363127 5674 79375584
Nocturia 16.38 13.99 23 363107 13658 79367600
Hepatic steatosis 16.33 13.99 252 362878 37486 79343772
Subileus 16.30 13.99 3 363127 5651 79375607
Injection site extravasation 16.28 13.99 87 363043 9582 79371676
Spondylitis 16.26 13.99 53 363077 4678 79376580
Allergic oedema 16.20 13.99 19 363111 772 79380486
Left ventricular failure 16.14 13.99 12 363118 9569 79371689
Nerve block 16.08 13.99 18 363112 695 79380563
Aortic stenosis 16.04 13.99 7 363123 7488 79373770
Pre-eclampsia 16.01 13.99 6 363124 7035 79374223
Tendon disorder 15.95 13.99 70 363060 7116 79374142
Product administered to patient of inappropriate age 15.89 13.99 3 363127 5550 79375708
Choking 15.88 13.99 19 363111 12082 79369176
Diaphragmatic rupture 15.87 13.99 11 363119 220 79381038
Abdominal pain upper 15.87 13.99 1204 361926 222615 79158643
Secretion discharge 15.85 13.99 120 363010 14902 79366356
Areflexia 15.82 13.99 3 363127 5531 79375727
Bronchitis viral 15.77 13.99 23 363107 1160 79380098
Vascular access site pain 15.77 13.99 9 363121 126 79381132
Endocrine ophthalmopathy 15.77 13.99 18 363112 710 79380548
Bacille Calmette-Guerin scar reactivation 15.76 13.99 6 363124 30 79381228
Muscle abscess 15.75 13.99 22 363108 1066 79380192
Human anti-human antibody test 15.70 13.99 14 363116 409 79380849
Aplasia 15.67 13.99 8 363122 7812 79373446
Cytomegalovirus chorioretinitis 15.64 13.99 3 363127 5487 79375771
Macular degeneration 15.62 13.99 17 363113 11279 79369979
Gastric ulcer haemorrhage 15.61 13.99 11 363119 9016 79372242
Product dose omission in error 15.55 13.99 8 363122 7780 79373478
Breast cancer metastatic 15.52 13.99 10 363120 8592 79372666
Pulmonary congestion 15.49 13.99 67 363063 27033 79354225
Bone density increased 15.48 13.99 19 363111 810 79380448
Flank pain 15.43 13.99 43 363087 19801 79361457
Disseminated mucormycosis 15.37 13.99 18 363112 730 79380528
Apathy 15.36 13.99 22 363108 12955 79368303
Impaired driving ability 15.34 13.99 3 363127 5412 79375846
Rhinitis allergic 15.33 13.99 20 363110 12249 79369009
Clonus 15.27 13.99 6 363124 6834 79374424
Non-small cell lung cancer 15.18 13.99 5 363125 6355 79374903
Electrocardiogram T wave inversion 15.17 13.99 3 363127 5369 79375889
Product storage error 15.11 13.99 32 363098 16194 79365064
Acute graft versus host disease in skin 15.10 13.99 8 363122 7650 79373608
Pulmonary trichosporonosis 15.04 13.99 7 363123 62 79381196
Dry eye 14.99 13.99 244 362886 36687 79344571
Spinal stenosis 14.94 13.99 123 363007 15668 79365590
Blood culture positive 14.93 13.99 10 363120 8419 79372839
Eosinophilic pneumonia 14.92 13.99 3 363127 5307 79375951
BK virus infection 14.87 13.99 11 363119 8793 79372465
Aortic valve stenosis 14.86 13.99 3 363127 5291 79375967
Sputum discoloured 14.85 13.99 50 363080 21693 79359565
Bacterial myositis 14.83 13.99 4 363126 4 79381254
Device failure 14.81 13.99 5 363125 6256 79375002
Bronchopulmonary aspergillosis 14.77 13.99 161 362969 22133 79359125
Duodenitis 14.73 13.99 9 363121 7958 79373300
Carotid artery stenosis 14.71 13.99 11 363119 8747 79372511
CD4/CD8 ratio increased 14.65 13.99 5 363125 17 79381241
Concussion 14.64 13.99 13 363117 9490 79371768
Catheter site erythema 14.64 13.99 3 363127 5237 79376021
Diabetes insipidus 14.63 13.99 3 363127 5234 79376024
Multiple system atrophy 14.60 13.99 13 363117 379 79380879
Facial pain 14.55 13.99 21 363109 12329 79368929
Wheezing 14.54 13.99 412 362718 116252 79265006
Clostridial infection 14.53 13.99 4 363126 5710 79375548
Abscess limb 14.51 13.99 67 363063 6960 79374298
Skin haemorrhage 14.49 13.99 20 363110 11961 79369297
Pseudomonal sepsis 14.48 13.99 5 363125 6169 79375089
Lacrimation increased 14.48 13.99 53 363077 22424 79358834
Exposure via skin contact 14.47 13.99 12 363118 317 79380941
Hepatitis E antibody positive 14.41 13.99 11 363119 257 79381001
Gait disturbance 14.40 13.99 785 362345 206721 79174537
Visual field defect 14.39 13.99 12 363118 9033 79372225
Hepatic cancer 14.39 13.99 16 363114 10513 79370745
Parosmia 14.32 13.99 7 363123 7007 79374251
Sluggishness 14.29 13.99 6 363124 6566 79374692
Wrong product administered 14.28 13.99 12 363118 9000 79372258
Gastritis erosive 14.26 13.99 17 363113 10830 79370428
Renal cancer 14.20 13.99 21 363109 12205 79369053
Abscess rupture 14.18 13.99 12 363118 326 79380932
Pigmentation disorder 14.16 13.99 4 363126 5614 79375644
Catheter site haemorrhage 14.15 13.99 3 363127 5114 79376144
Blood thyroid stimulating hormone increased 14.11 13.99 14 363116 9694 79371564
Hyperlactacidaemia 14.07 13.99 4 363126 5591 79375667
Coronary artery bypass 14.06 13.99 5 363125 6057 79375201
Red blood cell sedimentation rate decreased 14.05 13.99 11 363119 267 79380991
Mouth swelling 14.02 13.99 5 363125 6046 79375212
Head discomfort 14.02 13.99 28 363102 14474 79366784
Facial bones fracture 14.01 13.99 3 363127 5079 79376179

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AC07 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
FDA MoA N0000190478 Interleukin 6 Receptor Antagonists
FDA EPC N0000190480 Interleukin-6 Receptor Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Castleman's disease indication 207036003 DOID:0111157
Juvenile idiopathic arthritis indication 410502007
Still's disease indication 410794002
Juvenile rheumatoid arthritis indication 410795001
Juvenile seropositive polyarthritis indication 410796000
Juvenile seronegative polyarthritis indication 410797009
Juvenile idiopathic arthritis, extended oligoarthritis indication 410800006
Giant cell arteritis indication 414341000 DOID:13375
Cytokine release syndrome induced by tumor-specific T-cell infusion therapy indication 710027002
Pneumonia caused by Severe acute respiratory syndrome coronavirus 2 indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Interleukin-6 receptor Membrane receptor ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D02596 KEGG_DRUG
4029705 VUID
N0000180629 NUI
4029705 VANDF
CHEMBL1237022 ChEMBL_ID
C502936 MESH_SUPPLEMENTAL_RECORD_UI
6881 IUPHAR_LIGAND_ID
DB06273 DRUGBANK_ID
612865 RXNORM
169600 MMSL
26778 MMSL
d07496 MMSL
013198 NDDF
444648007 SNOMEDCT_US
444649004 SNOMEDCT_US
C1609165 UMLSCUI
8394 INN_ID
10150081 PUBCHEM_CID
I031V2H011 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-135 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-135 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-135 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-135 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-136 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-136 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-136 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-136 INJECTION, SOLUTION, CONCENTRATE 200 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-137 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-137 INJECTION, SOLUTION, CONCENTRATE 400 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-137 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-137 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
Actemra HUMAN PRESCRIPTION DRUG LABEL 1 50242-138 INJECTION, SOLUTION 162 mg SUBCUTANEOUS BLA 33 sections
Actemra HUMAN PRESCRIPTION DRUG LABEL 1 50242-138 INJECTION, SOLUTION 180 mg SUBCUTANEOUS BLA 33 sections
Actemra HUMAN PRESCRIPTION DRUG LABEL 1 50242-138 INJECTION, SOLUTION 180 mg SUBCUTANEOUS BLA 33 sections
Actemra HUMAN PRESCRIPTION DRUG LABEL 1 50242-138 INJECTION, SOLUTION 180 mg SUBCUTANEOUS BLA 33 sections
Actemra ACTPen HUMAN PRESCRIPTION DRUG LABEL 1 50242-143 INJECTION, SOLUTION 180 mg SUBCUTANEOUS BLA 33 sections
Actemra ACTPen HUMAN PRESCRIPTION DRUG LABEL 1 50242-143 INJECTION, SOLUTION 180 mg SUBCUTANEOUS BLA 33 sections
Actemra ACTPen HUMAN PRESCRIPTION DRUG LABEL 1 50242-143 INJECTION, SOLUTION 162 mg SUBCUTANEOUS BLA 33 sections
Actemra ACTPen HUMAN PRESCRIPTION DRUG LABEL 1 50242-143 INJECTION, SOLUTION 180 mg SUBCUTANEOUS BLA 33 sections