ticlatone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4734 70-10-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ticlatone
  • ticlaton
  • landromil
  • Molecular weight: 185.63
  • Formula: C7H4ClNOS
  • CLOGP: 1.32
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 29.10
  • ALOGS: -2.40
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.531 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.783 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 76.384 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 20.749 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 2.740 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 5.550 % High 1
herg hERG pIC50 4.220 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 19.454 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 27.353 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 1.900 % High 1
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,GSK3B,IRAK1,ITK,JAK1,JAK2,MAP3K1,MAP3K10,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK12,MAPK7,MAPK9,MARK4,MET,MTOR,NTRK2,PAK4,PDK1,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 57
kinase-selectivity-class ACVR2B,AXL,CDK9,DYRK1B,EIF2AK3,GRK2,MAP2K3,MAPK7,MARK4,PRKCZ,STK33,TEK,TTK 13
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.052 High 1
mh-clint Mouse hepatocyte intrinsic clearance 309.742 High 1
mppb Mouse plasma protein binding (% unbound) 4.550 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.237 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 2.130 % High 1
rh-clint Rat hepatocyte intrinsic clearance 22.491 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 80.510 % High 1
rppb Rat plasma protein binding (% unbound) 2.470 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 505.825 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AE08 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use

Related Drugs by ATC class:

D01AE Other antifungals for topical use 23 drugs
2-(4-chlorphenoxy)-ethanolamorolfinebromochlorosalicylanilidebutenafinechlorphenesin carbamateciclopiroxdimazoleethyl hydroxybenzoateflucytosinehaloproginliranaftatemethylrosaniline show all 23 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.6 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D06139 KEGG_DRUG
CHEBI:136026 CHEBI
CHEMBL2103914 ChEMBL_ID
C000409 MESH_SUPPLEMENTAL_RECORD_UI
DB13613 DRUGBANK_ID
BHW384Q9GI UNII
C0600823 UMLSCUI
2888 INN_ID
6258 PUBCHEM_CID

Pharmaceutical products:

None