haloprogin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1355 777-11-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • haloprogine
  • haloprogin
minor descriptor (73-86); on-line & INDEX MEDICUS search PHENYL ETHERS (73-86)
  • Molecular weight: 361.38
  • Formula: C9H4Cl3IO
  • CLOGP: 5.23
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -4.78
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA WESTWOOD SQUIBB

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AE11 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Tinea corporis indication 84849002
Tinea cruris indication 399029005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(1A) dopamine receptor GPCR Ki 6.55 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 6.34 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 6.37 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.56 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.16 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.87 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.73 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 6.60 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.78 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.23 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.81 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 6.90 DRUG MATRIX
Kappa-type opioid receptor GPCR Ki 6.34 DRUG MATRIX
Substance-K receptor GPCR Ki 6.31 DRUG MATRIX
UDP-glucose 4-epimerase Enzyme IC50 6.30 CHEMBL

External reference:

IDSource
4018665 VUID
N0000146976 NUI
D00339 KEGG_DRUG
4018665 VANDF
C0062106 UMLSCUI
CHEBI:5614 CHEBI
CHEMBL1289 ChEMBL_ID
DB00793 DRUGBANK_ID
C100276 MESH_SUPPLEMENTAL_RECORD_UI
3561 PUBCHEM_CID
2263 INN_ID
AIU7053OWL UNII
26422 RXNORM
4819 MMSL
002913 NDDF
387251004 SNOMEDCT_US
46436003 SNOMEDCT_US

Pharmaceutical products:

None