bromochlorosalicylanilide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
brominated salicylamide derivatives disinfectant 3040 3679-64-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bromosalicylchloranilide
  • bromochlorosalicylanilide
  • clobromsalan
  • Molecular weight: 326.57
  • Formula: C13H9BrClNO2
  • CLOGP: 5.23
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 2
  • TPSA: 49.33
  • ALOGS: -4.29
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 4.303 Moderate 0.66
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.422 Moderate 0.66
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 19.011 10^-6 cm/s Moderate 0.66
dh-clint Dog hepatocyte intrinsic clearance 82.604 uL/min/10^6 cells Moderate 0.66
dppb Dog plasma protein binding (% unbound) 0.140 % Moderate 0.66
fcs-ppb Fetal calf serum protein binding (% unbound) 0.170 % Moderate 0.66
herg hERG pIC50 4.676 pIC50 Moderate 0.66
hh-clint Human hepatocyte intrinsic clearance 332.660 uL/min/10^6 cells Moderate 0.66
hlm-clint Human liver microsomal intrinsic clearance 49.091 uL/min/mg protein Moderate 0.66
hppb Human plasma protein binding (% unbound) 0.320 % Moderate 0.66
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK19,CDK2,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FGFR1,FLT3,GRK1,GRK2,GRK3,GSK3A,GSK3B,IKBKB,IRAK1,ITK,JAK1,JAK2,KDR,KIT,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PIM3,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK10,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2 83
kinase-selectivity-class ACVR2B,DYRK1B,GRK2,PDK4,TTK 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.962 Moderate 0.66
mh-clint Mouse hepatocyte intrinsic clearance 373.250 Moderate 0.66
mppb Mouse plasma protein binding (% unbound) 0.180 Moderate 0.66
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.165 Moderate 0.66
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 0.260 % Moderate 0.66
rh-clint Rat hepatocyte intrinsic clearance 374.973 uL/min/10^6 cells Moderate 0.66
rh-fuinc Rat hepatocyte fraction unbound in incubation 3.120 % Moderate 0.66
rppb Rat plasma protein binding (% unbound) 0.170 % Moderate 0.66
solubility-dd Solubility at pH 7.4 in DMSO 2.051 uM Moderate 0.66

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AE01 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use

Related Drugs by ATC class:

D01AE Other antifungals for topical use 23 drugs
2-(4-chlorphenoxy)-ethanolamorolfinebutenafinechlorphenesin carbamateciclopiroxdimazoleethyl hydroxybenzoateflucytosinehaloproginliranaftatemethylrosanilinenaftifine show all 23 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.26 acidic
pKa2 10.05 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C0770939 UMLSCUI
CHEBI:135394 CHEBI
CHEMBL153192 ChEMBL_ID
DB13696 DRUGBANK_ID
6GK715PWMQ UNII
77254 PUBCHEM_CID
003719 NDDF

Pharmaceutical products:

None