All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

butenafine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
squalene monooxygenase inhibitors, antifungals	444	101828-21-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: KP-363 KP 363 butenafine butenafine hydrochloride butenafine HCl	studied on experimental dermatophytosis Molecular weight: 317.48 Formula: C23H27N CLOGP: 6.74 LIPINSKI: 1 HAC: 1 HDO: 0 TPSA: 3.24 ALOGS: -6.62 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 18, 1996	FDA	MYLAN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D01AE23	DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Other antifungals for topical use
FDA CS	M0002392	Benzylamines
CHEBI has role	CHEBI:59285	squalene monooxygenase inhibitors
CHEBI has role	CHEBI:86327	pharmaceutical fungicide
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents
FDA EPC	N0000175875	Benzylamine Antifungal

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Tinea pedis	indication	6020002	DOID:12403
Pityriasis versicolor	indication	56454009	DOID:9060
Tinea corporis	indication	84849002
Tinea cruris	indication	399029005

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.59	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	5.78		DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	6.13		DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.41		DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6.52		DRUG MATRIX
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	5.16		DRUG MATRIX
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	5.86		DRUG MATRIX
Squalene epoxidase	Enzyme		Q4JEY0_TRIRU	INHIBITOR				CHEMBL	CHEMBL
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		Ki	6.81		DRUG MATRIX
Enoyl-[acyl-carrier-protein] reductase [NADH]	Enzyme		Q5NGQ3_FRATT		IC50	4.12		CHEMBL
Squalene monooxygenase	Enzyme		ERG1_CANAL		IC50	7.35		WOMBAT-PK

External reference:

ID	Source
4024054	VUID
N0000022059	NUI
D01093	KEGG_DRUG
101827-46-7	SECONDARY_CAS_RN
236558	RXNORM
CHEBI:3238	CHEBI
CHEMBL990	ChEMBL_ID
CHEMBL1200397	ChEMBL_ID
C067594	MESH_SUPPLEMENTAL_RECORD_UI
6550	INN_ID
DB01091	DRUGBANK_ID
91Y494NL0X	UNII
14815	MMSL
266673	MMSL
4313	MMSL
108923003	SNOMEDCT_US
108924009	SNOMEDCT_US
373449007	SNOMEDCT_US
C0107497	UMLSCUI
4021015	VANDF
4024054	VANDF
2484	PUBCHEM_CID
006293	NDDF
006294	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Athletes Foot	HUMAN OTC DRUG LABEL	1	0363-2100	CREAM	10 mg	TOPICAL	ANDA	14 sections
Jock Itch	HUMAN OTC DRUG LABEL	1	0363-2101	CREAM	10 mg	TOPICAL	ANDA	14 sections
MENTAX	HUMAN PRESCRIPTION DRUG LABEL	1	0378-6151	CREAM	10 mg	TOPICAL	NDA	17 sections
Lotrimin Ultra	HUMAN OTC DRUG LABEL	1	11523-0082	CREAM	1 g	TOPICAL	NDA	14 sections
Lotrimin Ultra	HUMAN OTC DRUG LABEL	1	11523-0082	CREAM	1 g	TOPICAL	NDA	14 sections
Lotrimin UltraAthletes Foot	HUMAN OTC DRUG LABEL	1	11523-4338	CREAM	1 g	TOPICAL	NDA	13 sections
Lotrimin UltraAthletes Foot	HUMAN OTC DRUG LABEL	1	11523-4338	CREAM	1 g	TOPICAL	NDA	13 sections
Lotrimin UltraAthletes Foot	HUMAN OTC DRUG LABEL	1	11523-4338	CREAM	1 g	TOPICAL	NDA	13 sections
Lotrimin UltraJock Itch	HUMAN OTC DRUG LABEL	1	11523-4339	CREAM	1 g	TOPICAL	NDA	13 sections
Lotrimin UltraJock Itch	HUMAN OTC DRUG LABEL	1	11523-4339	CREAM	1 g	TOPICAL	NDA	13 sections
Lotrimin UltraAntifungal	HUMAN OTC DRUG LABEL	1	11523-7154	CREAM	10 mg	TOPICAL	NDA	14 sections
Lotrimin Ultra Jock ItchAntifungal	HUMAN OTC DRUG LABEL	1	11523-7155	CREAM	10 mg	TOPICAL	NDA	14 sections
Athletes Foot	HUMAN OTC DRUG LABEL	1	11673-016	CREAM	10 mg	TOPICAL	ANDA	14 sections
Athletes Foot	HUMAN OTC DRUG LABEL	1	11822-2100	CREAM	10 mg	TOPICAL	ANDA	14 sections
Butenafine Hydrochloride	HUMAN OTC DRUG LABEL	1	21130-965	CREAM	10 mg	TOPICAL	ANDA	14 sections
Butenafine Hydrochloride Athletes Foot	HUMAN OTC DRUG LABEL	1	30142-210	CREAM	10 mg	TOPICAL	ANDA	14 sections
Athletes Foot	HUMAN OTC DRUG LABEL	1	36800-049	CREAM	10 mg	TOPICAL	ANDA	14 sections
Athletes Foot Ultra	HUMAN OTC DRUG LABEL	1	37808-013	CREAM	10 mg	TOPICAL	ANDA	14 sections
Butenafine Hydrochloride Jock Itch	HUMAN OTC DRUG LABEL	1	49035-178	CREAM	10 mg	TOPICAL	ANDA	14 sections
Athletes Foot Ultra	HUMAN OTC DRUG LABEL	1	49035-225	CREAM	10 mg	TOPICAL	ANDA	14 sections
Athletes Foot	HUMAN OTC DRUG LABEL	1	51672-2100	CREAM	10 mg	TOPICAL	ANDA	14 sections
Jock Itch	HUMAN OTC DRUG LABEL	1	51672-2101	CREAM	10 mg	TOPICAL	ANDA	14 sections
Athletes Foot	HUMAN OTC DRUG LABEL	1	69842-986	CREAM	10 mg	TOPICAL	ANDA	14 sections
Athletes Foot	HUMAN OTC DRUG LABEL	1	69842-986	CREAM	10 mg	TOPICAL	ANDA	14 sections
Butenafine Hydrochloride 1%	HUMAN OTC DRUG LABEL	1	69842-989	CREAM	10 mg	TOPICAL	ANDA	14 sections
Butenafine Hydrochloride 1%	HUMAN OTC DRUG LABEL	1	69842-989	CREAM	10 mg	TOPICAL	ANDA	14 sections