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butenafine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| squalene monooxygenase inhibitors, antifungals | 444 | 101828-21-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
studied on experimental dermatophytosis
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK | 52 | |||
| kinase-selectivity-class | AXL,BRAF,EPHB4,GRK2 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 18, 1996 | FDA | MYLAN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D01AE23 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Other antifungals for topical use |
| FDA CS | M0002392 | Benzylamines |
| CHEBI has role | CHEBI:59285 | EC 1.14.13.132 (squalene monooxygenase) inhibitor |
| CHEBI has role | CHEBI:86327 | antifungal drug |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000935 | Antifungal Agents |
| FDA EPC | N0000175875 | Benzylamine Antifungal |
| CHEBI has role | CHEBI:50177 | dermatologic drug |
Related Drugs by ATC class:
D01AE Other antifungals for topical use 23 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Tinea pedis | indication | 6020002 | DOID:12403 |
| Pityriasis versicolor | indication | 56454009 | DOID:9060 |
| Tinea corporis | indication | 84849002 | |
| Tinea cruris | indication | 399029005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.59 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 5.78 | DRUG MATRIX | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 6.13 | DRUG MATRIX | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.41 | DRUG MATRIX | |||||
| Cytochrome P450 2D6 | Enzyme | IC50 | 6.52 | DRUG MATRIX | |||||
| Acetylcholinesterase | Enzyme | IC50 | 5.16 | DRUG MATRIX | |||||
| Alpha-2A adrenergic receptor | GPCR | Ki | 5.86 | DRUG MATRIX | |||||
| Squalene epoxidase | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 6.81 | DRUG MATRIX | |||||
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Enzyme | IC50 | 4.12 | CHEMBL | |||||
| Squalene monooxygenase | Enzyme | IC50 | 7.35 | WOMBAT-PK | |||||
| Replicase polyprotein 1ab | Enzyme | IC50 | 5.27 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4024054 | VUID |
| N0000022059 | NUI |
| D01093 | KEGG_DRUG |
| 236558 | RXNORM |
| CHEBI:3238 | CHEBI |
| CHEMBL990 | ChEMBL_ID |
| CHEMBL1200397 | ChEMBL_ID |
| C067594 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6550 | INN_ID |
| 101827-46-7 | SECONDARY_CAS_RN |
| DB01091 | DRUGBANK_ID |
| 91Y494NL0X | UNII |
| 14815 | MMSL |
| 266673 | MMSL |
| 4313 | MMSL |
| 108923003 | SNOMEDCT_US |
| 108924009 | SNOMEDCT_US |
| 373449007 | SNOMEDCT_US |
| C0107497 | UMLSCUI |
| 2484 | PUBCHEM_CID |
| 4021015 | VANDF |
| 4024054 | VANDF |
| 006293 | NDDF |
| 006294 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Athletes Foot | HUMAN OTC DRUG LABEL | 1 | 0363-2100 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Jock Itch | HUMAN OTC DRUG LABEL | 1 | 0363-2101 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Lotrimin Ultra | HUMAN OTC DRUG LABEL | 1 | 11523-0082 | CREAM | 1 g | TOPICAL | NDA | 14 sections |
| Lotrimin UltraRingworm | HUMAN OTC DRUG LABEL | 1 | 11523-0158 | CREAM | 1 g | TOPICAL | NDA | 13 sections |
| Lotrimin UltraAthletes Foot | HUMAN OTC DRUG LABEL | 1 | 11523-4338 | CREAM | 1 g | TOPICAL | NDA | 13 sections |
| Lotrimin UltraJock Itch | HUMAN OTC DRUG LABEL | 1 | 11523-4339 | CREAM | 1 g | TOPICAL | NDA | 13 sections |
| Athletes Foot | HUMAN OTC DRUG LABEL | 1 | 11673-016 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Jock Itch Cream | HUMAN OTC DRUG LABEL | 1 | 11673-436 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Athletes Foot | HUMAN OTC DRUG LABEL | 1 | 11822-2100 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Butenafine Hydrochloride | HUMAN OTC DRUG LABEL | 1 | 21130-965 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Butenafine Hydrochloride Athletes Foot | HUMAN OTC DRUG LABEL | 1 | 30142-210 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Athletes Foot | HUMAN OTC DRUG LABEL | 1 | 36800-049 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Athletes Foot Ultra | HUMAN OTC DRUG LABEL | 1 | 37808-013 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Butenafine Hydrochloride Jock Itch | HUMAN OTC DRUG LABEL | 1 | 49035-178 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Athletes Foot Ultra | HUMAN OTC DRUG LABEL | 1 | 49035-225 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Athletes Foot | HUMAN OTC DRUG LABEL | 1 | 51672-2100 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Jock Itch | HUMAN OTC DRUG LABEL | 1 | 51672-2101 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Athletes Foot | HUMAN OTC DRUG LABEL | 1 | 69842-986 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Butenafine Hydrochloride 1% | HUMAN OTC DRUG LABEL | 1 | 69842-989 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Athletes Foot | HUMAN OTC DRUG LABEL | 1 | 70677-1269 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Butenafine Hydrochloride | HUMAN OTC DRUG LABEL | 1 | 73581-210 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |
| Butenafine Hydrochloride | HUMAN OTC DRUG LABEL | 1 | 79481-0086 | CREAM | 10 mg | TOPICAL | ANDA | 14 sections |