pyrithione zinc Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4248 13463-41-7

Description:

MoleculeDescription

Synonyms:

  • pyrithione zinc
  • zinc pyrithione
dimer of two pyrithione molecules bound by zinc; ingredient of commercial anti-dandruff shampoos; Do not confuse zinc pyrithione with Raman spectrum probe dye known as zincon; antifungal and antibacterial
  • Molecular weight: 317.69
  • Formula: C10H8N2O2S2Zn
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AX12 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
MeSH PA D003879 Dermatologic Agents
MeSH PA D007641 Keratolytic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Seborrheic dermatitis indication 50563003 DOID:8741
Pityriasis simplex indication 200767005

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 12 Enzyme Ki 5.27 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 5.21 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 5.38 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.79 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 5.29 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 5.54 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 5.11 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 5.76 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 5.45 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 5.62 CHEMBL

External reference:

IDSource
4020508 VUID
N0000179286 NUI
C0078792 UMLSCUI
D01938 KEGG_DRUG
411297004 SNOMEDCT_US
4019187 VANDF
4020508 VANDF
39952 RXNORM
4999 MMSL
255954005 SNOMEDCT_US
5397 MMSL
002961 NDDF
CHEMBL1200471 ChEMBL_ID
R953O2RHZ5 UNII
2295 INN_ID
CHEBI:32076 CHEBI
CHEMBL3392049 ChEMBL_ID
26041 PUBCHEM_CID
2597 IUPHAR_LIGAND_ID
C010423 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dandruff HUMAN OTC DRUG LABEL 1 0363-0253 SHAMPOO 10 mg TOPICAL OTC monograph final 12 sections
Dry Scalp Care HUMAN OTC DRUG LABEL 1 0363-0688 SHAMPOO 10 mg TOPICAL OTC monograph final 13 sections
2 in 1 Dandruff HUMAN OTC DRUG LABEL 1 0363-0755 SHAMPOO 10 mg TOPICAL OTC monograph final 12 sections
Dandruff HUMAN OTC DRUG LABEL 1 0869-0153 SHAMPOO 10 mg TOPICAL OTC monograph final 12 sections
Satinique Anti Dandruff HUMAN OTC DRUG LABEL 1 10056-006 CREAM 95 mg TOPICAL OTC monograph final 7 sections
Advance Techniques Keep Clear HUMAN OTC DRUG LABEL 1 10096-0220 LOTION 0.15 mL TOPICAL OTC monograph final 6 sections
Advance Techniques Keep Clear HUMAN OTC DRUG LABEL 1 10096-0221 SHAMPOO 10 mg TOPICAL OTC monograph final 6 sections
Neutrogena Tgel Daily Control 2 in 1 HUMAN OTC DRUG LABEL 1 10812-152 SHAMPOO 10 mg TOPICAL OTC MONOGRAPH FINAL 9 sections
American Crew HUMAN OTC DRUG LABEL 1 10967-650 SHAMPOO 1 mg TOPICAL OTC monograph final 8 sections
Dandruff HUMAN OTC DRUG LABEL 1 11344-253 SHAMPOO 10 mg TOPICAL OTC monograph final 11 sections
Fresh Mint Dandruff HUMAN OTC DRUG LABEL 1 11344-309 SHAMPOO 1 kg TOPICAL OTC monograph final 7 sections
2 in 1 Dandruff HUMAN OTC DRUG LABEL 1 11344-311 SHAMPOO 10 mg TOPICAL OTC monograph final 12 sections
Dandruff HUMAN OTC DRUG LABEL 1 11344-443 SHAMPOO 10.40 mg TOPICAL OTC monograph final 12 sections
Dandruff HUMAN OTC DRUG LABEL 1 11344-475 SHAMPOO 1 mg TOPICAL OTC monograph final 12 sections
Dandruff HUMAN OTC DRUG LABEL 1 11344-514 SHAMPOO 1 mg TOPICAL OTC monograph final 12 sections
Dandruff HUMAN OTC DRUG LABEL 1 11344-531 SHAMPOO, SUSPENSION 958 mg TOPICAL OTC monograph final 12 sections
2 in 1 Dandruff HUMAN OTC DRUG LABEL 1 11344-612 SHAMPOO 1 g TOPICAL OTC monograph final 11 sections
pyrithione zinc HUMAN OTC DRUG LABEL 1 11344-928 SHAMPOO 10.40 mg TOPICAL OTC monograph final 11 sections
Just For Men Control GX Anti-Dandruff HUMAN OTC DRUG LABEL 1 11509-5225 SHAMPOO 10 mg TOPICAL OTC MONOGRAPH FINAL 8 sections
2 in 1 HUMAN OTC DRUG LABEL 1 11673-011 SHAMPOO 10.40 mg TOPICAL OTC monograph final 12 sections
Everyday Clean Dandruff HUMAN OTC DRUG LABEL 1 11673-153 SHAMPOO 10 mg TOPICAL OTC monograph final 13 sections
Smooth and glossy HUMAN OTC DRUG LABEL 1 11673-214 SHAMPOO 10.40 mg TOPICAL OTC monograph final 13 sections
Dandruff HUMAN OTC DRUG LABEL 1 11673-253 SHAMPOO 10 mg TOPICAL OTC monograph final 12 sections
Dandruff HUMAN OTC DRUG LABEL 1 11673-281 SHAMPOO 10 mg TOPICAL OTC monograph final 13 sections
2 in 1 HUMAN OTC DRUG LABEL 1 11673-836 SHAMPOO 10.30 mg TOPICAL OTC monograph final 12 sections
Rite Aid Dandruff HUMAN OTC DRUG LABEL 1 11822-4101 SHAMPOO 1 mL TOPICAL OTC monograph final 7 sections
Rite Aid Dandruff HUMAN OTC DRUG LABEL 1 11822-4111 SHAMPOO 1 mL TOPICAL OTC monograph final 7 sections
Daylogic 2in1 Dandruff Classic Clean HUMAN OTC DRUG LABEL 1 11822-4242 LIQUID 10 mg TOPICAL OTC monograph final 6 sections
Daylogic 2in1 Dandruff Dry Scalp Care HUMAN OTC DRUG LABEL 1 11822-4251 LIQUID 10 mg TOPICAL OTC monograph final 6 sections
Daylogic Dandruff Classic Clean HUMAN OTC DRUG LABEL 1 11822-4272 LIQUID 10 mg TOPICAL OTC monograph final 6 sections