tolciclate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3614 50838-36-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tolciclate
  • fungifos
  • kilmicen
  • tolmicen
  • Molecular weight: 323.45
  • Formula: C20H21NOS
  • CLOGP: 5.49
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -5.94
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,STK33,TEK,TTK 34
kinase-selectivity-class AXL,EIF2AK3,GRK2,PDK4 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AE19 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
CHEBI has role CHEBI:86327 antifungal drug

Related Drugs by ATC class:

D01AE Other antifungals for topical use 23 drugs
2-(4-chlorphenoxy)-ethanolamorolfinebromochlorosalicylanilidebutenafinechlorphenesin carbamateciclopiroxdimazoleethyl hydroxybenzoateflucytosinehaloproginliranaftatemethylrosaniline show all 23 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01384 KEGG_DRUG
C0076793 UMLSCUI
CHEBI:32242 CHEBI
CHEMBL2105485 ChEMBL_ID
DB13360 DRUGBANK_ID
C013305 MESH_SUPPLEMENTAL_RECORD_UI
92169693 PUBCHEM_CID
3811 INN_ID
T3TZ02X2AZ UNII
38372 RXNORM
006024 NDDF

Pharmaceutical products:

None