riboflavin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2834 83-88-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • riboflavine
  • beflavine
  • lactoflavin
  • lactoflavine
  • Vitamin B2
  • riboflavin (vit B2)
  • riboflavin
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.
  • Molecular weight: 376.37
  • Formula: C17H20N4O6
  • CLOGP: -0.73
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 5
  • TPSA: 155.05
  • ALOGS: -2.76
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.09 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1777.11 10.31 4404 526666 179322 62778630
Systemic lupus erythematosus 1676.98 10.31 4671 526399 204247 62753705
Glossodynia 1484.22 10.31 4049 527021 174827 62783125
Hand deformity 1209.92 10.31 3495 527575 155962 62801990
Arthropathy 1122.03 10.31 4404 526666 230388 62727564
Abdominal discomfort 1042.12 10.31 5366 525704 315519 62642433
Alopecia 1032.13 10.31 5551 525519 331985 62625967
Wound 1002.99 10.31 3325 527745 159938 62798014
Completed suicide 958.42 10.31 67 531003 145606 62812346
Rheumatoid arthritis 892.96 10.31 4343 526727 249476 62708476
Maternal exposure during pregnancy 886.51 10.31 3918 527152 216144 62741808
Synovitis 800.16 10.31 3390 527680 183528 62774424
Toxicity to various agents 761.83 10.31 573 530497 246677 62711275
Anti-cyclic citrullinated peptide antibody positive 758.56 10.31 2417 528653 113795 62844157
Pericarditis 752.51 10.31 2617 528453 128962 62828990
Discomfort 746.32 10.31 3074 527996 164300 62793652
Swelling 743.58 10.31 4382 526688 270996 62686956
Contraindicated product administered 722.41 10.31 3664 527406 213984 62743968
Infusion related reaction 686.07 10.31 3943 527127 241578 62716374
Joint swelling 669.93 10.31 4862 526208 322804 62635148
Pain 593.66 10.31 9078 521992 731550 62226402
Death 536.68 10.31 1491 529579 372890 62585062
Duodenal ulcer perforation 478.02 10.31 1711 529359 85498 62872454
Rheumatoid factor positive 468.61 10.31 1663 529407 82743 62875209
Helicobacter infection 464.63 10.31 1768 529302 91017 62866935
Product use issue 450.42 10.31 3273 527797 217247 62740705
Drug interaction 436.60 10.31 780 530290 228351 62729601
Hepatic enzyme increased 412.54 10.31 3002 528068 199326 62758626
Intentional overdose 411.19 10.31 64 531006 74088 62883864
Arthralgia 383.75 10.31 6791 524279 562919 62395033
Drug abuse 383.56 10.31 71 530999 72447 62885505
Psoriatic arthropathy 349.38 10.31 1605 529465 89915 62868037
Musculoskeletal stiffness 339.56 10.31 2674 528396 181944 62776008
Therapeutic product effect decreased 323.42 10.31 2739 528331 190448 62767504
Drug intolerance 315.33 10.31 3955 527115 304706 62653246
Febrile neutropenia 315.26 10.31 315 530755 118134 62839818
Exposure during pregnancy 279.93 10.31 2242 528828 153305 62804647
Suicide attempt 276.11 10.31 83 530987 60835 62897117
Treatment failure 264.54 10.31 2686 528384 196357 62761595
Depressed level of consciousness 253.07 10.31 101 530969 61977 62895975
Acute kidney injury 250.84 10.31 1241 529829 262174 62695778
Hip arthroplasty 249.27 10.31 921 530149 46725 62911227
Knee arthroplasty 242.27 10.31 997 530073 53209 62904743
Cardiac arrest 241.81 10.31 250 530820 92295 62865657
Overdose 241.08 10.31 368 530702 114710 62843242
Hypersensitivity 232.90 10.31 3588 527482 289097 62668855
Malignant neoplasm progression 216.64 10.31 220 530850 81901 62876051
Rheumatic fever 210.35 10.31 815 530255 42296 62915656
Disease progression 206.73 10.31 449 530621 122309 62835643
Impaired healing 203.28 10.31 1512 529558 101030 62856922
Nasopharyngitis 199.15 10.31 3109 527961 251148 62706804
Neutropenia 191.38 10.31 783 530287 174222 62783730
Swollen joint count increased 183.63 10.31 691 530379 35363 62922589
Constipation 179.02 10.31 1124 529946 223819 62734133
Sedation 173.84 10.31 54 531016 38755 62919197
Folliculitis 170.84 10.31 1090 529980 69227 62888725
Electrocardiogram QT prolonged 170.50 10.31 148 530922 59382 62898570
Hyponatraemia 168.69 10.31 434 530636 111466 62846486
Blister 166.70 10.31 1740 529330 128074 62829878
Fatigue 166.13 10.31 9041 522029 878987 62078965
Red blood cell sedimentation rate abnormal 165.75 10.31 450 530620 19332 62938620
Muscle injury 165.01 10.31 1023 530047 64322 62893630
Bradycardia 164.35 10.31 223 530847 73004 62884948
Lactic acidosis 163.22 10.31 58 531012 38229 62919723
Nausea 151.46 10.31 5736 525334 848735 62109217
Cardiac failure 147.63 10.31 329 530741 88813 62869139
Sleep disorder due to general medical condition, insomnia type 146.27 10.31 840 530230 51377 62906575
Hypotension 145.55 10.31 1517 529553 271087 62686865
Rash 144.23 10.31 5896 525174 554975 62402977
Somnolence 142.05 10.31 893 530177 177792 62780160
Sickle cell anaemia with crisis 140.71 10.31 210 530860 5793 62952159
Irritable bowel syndrome 137.45 10.31 1168 529902 81244 62876708
Agitation 136.11 10.31 180 530890 59577 62898375
Renal failure 133.25 10.31 519 530551 117133 62840819
Drug reaction with eosinophilia and systemic symptoms 133.14 10.31 58 531012 33778 62924174
Diarrhoea 131.08 10.31 4782 526288 710584 62247368
Respiratory arrest 129.98 10.31 55 531015 32590 62925362
Hyperhidrosis 129.76 10.31 464 530606 107372 62850580
C-reactive protein abnormal 129.41 10.31 742 530328 45354 62912598
Drug hypersensitivity 128.94 10.31 1826 529244 308861 62649091
Rhabdomyolysis 128.64 10.31 107 530963 43844 62914108
Lower respiratory tract infection 122.45 10.31 1666 529404 130641 62827311
Neoplasm progression 121.84 10.31 77 530993 36351 62921601
Tremor 121.72 10.31 630 530440 131609 62826343
Asthenia 121.63 10.31 2369 528701 381235 62576717
Sopor 120.89 10.31 20 531050 22144 62935808
Intentional self-injury 120.07 10.31 33 531037 25654 62932298
Blood cholesterol increased 119.54 10.31 1258 529812 92774 62865178
Osteoarthritis 113.08 10.31 1258 529812 94085 62863867
Vomiting 112.71 10.31 3696 527374 555921 62402031
Dyspnoea 111.27 10.31 4465 526605 656848 62301104
Cardio-respiratory arrest 109.67 10.31 209 530861 59750 62898202
Anxiety 109.46 10.31 1227 529843 216314 62741638
Tachycardia 108.12 10.31 564 530506 117592 62840360
Coma 106.19 10.31 238 530832 64126 62893826
Thrombocytopenia 104.95 10.31 786 530284 150371 62807581
Liver injury 104.76 10.31 865 530205 59655 62898297
Arthritis 103.32 10.31 1450 529620 114471 62843481
Condition aggravated 103.11 10.31 4228 526842 397989 62559963
Serotonin syndrome 102.47 10.31 56 531014 28626 62929326
Pregnancy 101.48 10.31 590 530480 36246 62921706
Type 2 diabetes mellitus 101.16 10.31 895 530175 62973 62894979
Hypoglycaemia 100.82 10.31 220 530850 59845 62898107
Anaemia 100.75 10.31 1787 529283 291643 62666309
Syncope 99.36 10.31 575 530495 116810 62841142
Cognitive disorder 98.25 10.31 199 530871 55616 62902336
Fibromyalgia 98.07 10.31 1067 530003 79353 62878599
Contusion 95.55 10.31 1775 529295 148269 62809683
Renal impairment 94.84 10.31 398 530672 87957 62869995
Psoriasis 94.45 10.31 1128 529942 85829 62872123
Metabolic acidosis 92.54 10.31 146 530924 44923 62913029
No adverse event 90.98 10.31 128 530942 41277 62916675
Hepatic failure 89.01 10.31 100 530970 35556 62922396
Intentional product use issue 88.51 10.31 1533 529537 126359 62831593
Intentional product misuse 85.95 10.31 244 530826 60673 62897279
Peripheral swelling 85.59 10.31 2868 528202 263074 62694878
Drug resistance 84.55 10.31 43 531027 22890 62935062
Live birth 84.41 10.31 431 530639 25199 62932753
Sedation complication 83.65 10.31 9 531061 13813 62944139
Hepatic function abnormal 83.43 10.31 113 530957 37029 62920923
Ill-defined disorder 82.93 10.31 1047 530023 80708 62877244
Drug dependence 82.92 10.31 51 531019 24432 62933520
Hyperglycaemia 82.81 10.31 139 530931 41728 62916224
Drug ineffective 82.45 10.31 9956 521114 1034809 61923143
Orthostatic hypotension 82.26 10.31 109 530961 36051 62921901
Respiratory failure 81.95 10.31 507 530563 101351 62856601
Neuropathy peripheral 81.31 10.31 586 530484 113081 62844871
Multiple organ dysfunction syndrome 80.30 10.31 227 530843 56525 62901427
Abortion spontaneous 79.78 10.31 671 530399 46524 62911428
Joint effusion 79.54 10.31 318 530752 16742 62941210
Altered state of consciousness 79.45 10.31 57 531013 25173 62932779
Seizure 78.29 10.31 720 530350 131914 62826038
Macular degeneration 78.17 10.31 54 531016 24322 62933630
Myalgia 77.86 10.31 816 530254 145713 62812239
Angioedema 76.98 10.31 180 530890 47785 62910167
Asthma 76.36 10.31 690 530380 126871 62831081
Multiple sclerosis relapse 76.16 10.31 184 530886 48294 62909658
Blood pressure diastolic abnormal 75.94 10.31 281 530789 14261 62943691
Drug withdrawal syndrome 75.00 10.31 70 531000 27124 62930828
Blood pressure fluctuation 73.83 10.31 650 530420 45667 62912285
Dizziness 73.77 10.31 2895 528175 427030 62530922
Blood pressure systolic abnormal 73.57 10.31 263 530807 13123 62944829
Blood glucose increased 73.17 10.31 406 530664 83350 62874602
Sinusitis 72.82 10.31 2444 528626 224209 62733743
Hypoxia 72.09 10.31 257 530813 59535 62898417
Encephalopathy 71.17 10.31 134 530936 38486 62919466
Creatinine renal clearance decreased 70.72 10.31 24 531046 16284 62941668
Hallucination 70.58 10.31 229 530841 54588 62903364
Hepatocellular injury 70.33 10.31 75 530995 27306 62930646
Balance disorder 69.06 10.31 418 530652 84004 62873948
Red blood cell sedimentation rate increased 68.95 10.31 615 530455 43367 62914585
Device expulsion 68.09 10.31 117 530953 34805 62923147
Hyperkalaemia 68.03 10.31 229 530841 53974 62903978
Cytomegalovirus infection 67.74 10.31 46 531024 20906 62937046
Palmar-plantar erythrodysaesthesia syndrome 67.38 10.31 56 531014 22959 62934993
Disability assessment scale score increased 67.22 10.31 107 530963 3126 62954826
Anaphylactic reaction 67.13 10.31 304 530766 65796 62892156
Metastases to bone 66.83 10.31 47 531023 20972 62936980
Cholestasis 66.67 10.31 89 530981 29345 62928607
Weight increased 66.15 10.31 2739 528331 258053 62699899
Foot deformity 65.92 10.31 429 530641 27424 62930528
Product quality issue 65.60 10.31 125 530945 35740 62922212
Cardiac failure congestive 65.39 10.31 478 530592 91955 62865997
Dehydration 65.21 10.31 1038 530032 172316 62785636
Leukopenia 64.64 10.31 380 530690 76910 62881042
Vision blurred 64.25 10.31 477 530593 91447 62866505
Neutrophil count decreased 63.72 10.31 249 530821 56157 62901795
Chest discomfort 63.58 10.31 600 530470 109369 62848583
Myocardial infarction 62.13 10.31 535 530535 99358 62858594
Drug ineffective for unapproved indication 62.05 10.31 119 530951 33944 62924008
Basal cell carcinoma 61.36 10.31 423 530647 27568 62930384
Product use in unapproved indication 60.31 10.31 1094 529976 177986 62779966
Ejection fraction decreased 59.82 10.31 59 531011 22273 62935679
Poisoning 59.69 10.31 20 531050 13680 62944272
Osteonecrosis of jaw 59.47 10.31 128 530942 34995 62922957
Shock 59.45 10.31 65 531005 23398 62934554
Hypokalaemia 59.32 10.31 568 530502 103236 62854716
Grip strength decreased 58.82 10.31 353 530717 21934 62936018
Stomatitis 58.39 10.31 1547 529523 137178 62820774
Anaphylactic shock 58.21 10.31 67 531003 23566 62934386
Diabetic ketoacidosis 57.47 10.31 52 531018 20453 62937499
Cytokine release syndrome 57.17 10.31 24 531046 14290 62943662
Blood pressure systolic increased 56.91 10.31 627 530443 46770 62911182
Injection site erythema 56.81 10.31 995 530075 82179 62875773
Loss of consciousness 56.72 10.31 673 530397 117448 62840504
Blood creatine phosphokinase increased 56.58 10.31 105 530965 30325 62927627
Pulmonary fibrosis 56.54 10.31 545 530525 39264 62918688
Respiratory depression 56.40 10.31 22 531048 13693 62944259
Osteoporosis 56.32 10.31 730 530340 56608 62901344
Restlessness 56.22 10.31 100 530970 29353 62928599
Feeling abnormal 55.98 10.31 888 530182 147504 62810448
Juvenile idiopathic arthritis 55.76 10.31 100 530970 3226 62954726
Gamma-glutamyltransferase increased 55.18 10.31 127 530943 33904 62924048
Blood calcium decreased 54.96 10.31 85 530985 26366 62931586
Infection 54.96 10.31 2393 528677 226780 62731172
Suicidal ideation 54.84 10.31 302 530768 62119 62895833
COVID-19 54.47 10.31 644 530426 112459 62845493
Bone erosion 54.25 10.31 292 530778 17425 62940527
Disorientation 53.48 10.31 161 530909 39291 62918661
Drug level increased 53.30 10.31 67 531003 22669 62935283
Disturbance in attention 52.38 10.31 155 530915 38034 62919918
Ventricular tachycardia 52.13 10.31 54 531016 19925 62938027
White blood cell count decreased 51.94 10.31 834 530236 138270 62819682
Joint laxity 51.85 10.31 82 530988 2382 62955570
Dysphagia 51.77 10.31 482 530588 88103 62869849
Joint range of motion decreased 51.63 10.31 455 530615 31973 62925979
Mydriasis 51.15 10.31 18 531052 11938 62946014
Inflammation 50.85 10.31 969 530101 81304 62876648
Extrapyramidal disorder 50.34 10.31 24 531046 13260 62944692
Metastases to liver 50.04 10.31 75 530995 23564 62934388
Mental status changes 49.89 10.31 167 530903 39432 62918520
Wrong technique in product usage process 49.76 10.31 311 530759 62029 62895923
Acute hepatic failure 49.57 10.31 48 531022 18279 62939673
Joint destruction 49.18 10.31 139 530931 6113 62951839
Caesarean section 49.00 10.31 276 530794 16756 62941196
Platelet count decreased 48.94 10.31 680 530390 115442 62842510
Blood pressure decreased 48.55 10.31 331 530739 64691 62893261
Drug tolerance decreased 48.20 10.31 280 530790 17193 62940759
Disseminated intravascular coagulation 48.02 10.31 53 531017 18998 62938954
Loss of personal independence in daily activities 47.81 10.31 1108 529962 96182 62861770
Torsade de pointes 47.79 10.31 26 531044 13325 62944627
Abnormal behaviour 47.30 10.31 66 531004 21360 62936592
Cerebral haemorrhage 47.19 10.31 118 530952 30611 62927341
C-reactive protein increased 46.97 10.31 1080 529990 93627 62864325
Ascites 46.51 10.31 179 530891 40549 62917403
Posterior reversible encephalopathy syndrome 46.26 10.31 46 531024 17299 62940653
Speech disorder 46.12 10.31 179 530891 40450 62917502
Injection site reaction 45.82 10.31 716 530354 57808 62900144
Blood alkaline phosphatase increased 45.81 10.31 194 530876 42773 62915179
Sepsis 45.59 10.31 955 530115 152168 62805784
Palpitations 45.54 10.31 666 530404 112104 62845848
Neurotoxicity 45.38 10.31 45 531025 16945 62941007
Hypothermia 45.01 10.31 29 531041 13552 62944400
Dysarthria 44.83 10.31 194 530876 42517 62915435
Polyarthritis 44.82 10.31 186 530884 9960 62947992
Inappropriate antidiuretic hormone secretion 44.80 10.31 38 531032 15424 62942528
Urticaria 44.53 10.31 1051 530019 164751 62793201
Respiratory disorder 44.48 10.31 172 530898 38910 62919042
Unresponsive to stimuli 44.42 10.31 140 530930 33676 62924276
Insomnia 44.24 10.31 1417 529653 213835 62744117
Pulmonary embolism 44.08 10.31 698 530372 115986 62841966
Emotional distress 44.00 10.31 133 530937 32416 62925536
Injection site pruritus 43.72 10.31 573 530497 44543 62913409
Muscle spasticity 43.43 10.31 72 530998 21722 62936230
Blood bilirubin increased 42.56 10.31 163 530907 36977 62920975
Schizophrenia 42.54 10.31 15 531055 9937 62948015
Disability 42.45 10.31 281 530789 18066 62939886
Akathisia 42.28 10.31 12 531058 9134 62948818
Myelosuppression 42.14 10.31 84 530986 23619 62934333
Chronic kidney disease 41.90 10.31 216 530854 45182 62912770
Device difficult to use 41.50 10.31 28 531042 12768 62945184
Accidental exposure to product 41.49 10.31 106 530964 27299 62930653
Neuroleptic malignant syndrome 40.98 10.31 25 531045 12031 62945921
Polyneuropathy 40.89 10.31 37 531033 14552 62943400
Foetal exposure during pregnancy 40.77 10.31 428 530642 31534 62926418
Fluid retention 40.61 10.31 312 530758 59374 62898578
Blood pressure diastolic decreased 40.61 10.31 327 530743 22379 62935573
Flushing 40.33 10.31 417 530653 74670 62883282
Hepatotoxicity 40.26 10.31 166 530904 36875 62921077
Depression 40.26 10.31 1294 529776 195198 62762754
Psychotic disorder 40.06 10.31 98 530972 25614 62932338
Rheumatoid nodule 39.85 10.31 263 530807 16892 62941060
Blood creatinine increased 39.71 10.31 507 530563 87337 62870615
Gestational diabetes 39.54 10.31 157 530913 8239 62949713
Vertigo 39.38 10.31 316 530754 59571 62898381
Parkinsonism 39.35 10.31 19 531051 10420 62947532
Withdrawal syndrome 38.98 10.31 67 531003 19930 62938022
Dyskinesia 38.94 10.31 137 530933 31865 62926087
Respiratory distress 38.90 10.31 149 530921 33802 62924150
Hypomania 38.62 10.31 4 531066 6326 62951626
Eosinophilia 38.47 10.31 83 530987 22673 62935279
Neck deformity 38.45 10.31 66 531004 2055 62955897
Bone pain 38.43 10.31 283 530787 54358 62903594
Arrhythmia 38.37 10.31 176 530894 37964 62919988
Premature labour 38.23 10.31 206 530864 12298 62945654
Diabetes mellitus inadequate control 38.22 10.31 42 531028 15084 62942868
Toxic skin eruption 38.16 10.31 31 531039 12854 62945098
Accidental overdose 37.78 10.31 87 530983 23222 62934730
Stress cardiomyopathy 37.49 10.31 16 531054 9434 62948518
Pain in jaw 37.35 10.31 212 530858 43284 62914668
Multiple fractures 37.30 10.31 157 530913 8461 62949491
Tuberculosis 37.24 10.31 189 530881 11022 62946930
Thrombotic microangiopathy 37.17 10.31 21 531049 10540 62947412
Agranulocytosis 36.69 10.31 99 530971 25035 62932917
Haemorrhage 36.53 10.31 330 530740 60692 62897260
Acute generalised exanthematous pustulosis 36.38 10.31 24 531046 11075 62946877
Hospitalisation 36.28 10.31 497 530573 84584 62873368
Joint stiffness 36.18 10.31 521 530549 41348 62916604
Disease recurrence 36.15 10.31 117 530953 27913 62930039
Cerebrovascular accident 36.00 10.31 661 530409 107363 62850589
Product administration error 35.98 10.31 84 530986 22313 62935639
Ventricular fibrillation 35.83 10.31 28 531042 11839 62946113
Metastases to central nervous system 35.82 10.31 34 531036 13071 62944881
Decreased appetite 35.81 10.31 1725 529345 249327 62708625
Second primary malignancy 35.73 10.31 11 531059 7942 62950010
Adverse event 35.56 10.31 777 530293 66782 62891170
Exposure to toxic agent 35.50 10.31 3 531067 5584 62952368
Haematotoxicity 35.44 10.31 17 531053 9359 62948593
Dystonia 35.32 10.31 38 531032 13781 62944171
Pancreatitis acute 35.31 10.31 113 530957 27053 62930899
Brain oedema 35.22 10.31 40 531030 14155 62943797
Gastrointestinal haemorrhage 35.04 10.31 473 530597 80703 62877249
Depressed mood 35.00 10.31 195 530875 39996 62917956
Hypomagnesaemia 34.98 10.31 123 530947 28614 62929338
Pulmonary oedema 34.51 10.31 293 530777 54580 62903372
Colitis 34.29 10.31 251 530819 48277 62909675
Dysgeusia 34.27 10.31 239 530831 46471 62911481
Pyrexia 34.05 10.31 3431 527639 467047 62490905
Face oedema 33.94 10.31 74 530996 20138 62937814
Bronchospasm 33.59 10.31 58 531012 17222 62940730
Aspartate aminotransferase increased 33.44 10.31 542 530528 89735 62868217
Gastrointestinal disorder 33.36 10.31 1379 529691 129860 62828092
Miosis 33.34 10.31 10 531060 7343 62950609
Alanine aminotransferase increased 33.34 10.31 639 530431 103131 62854821
Maternal drugs affecting foetus 33.20 10.31 108 530962 5134 62952818
Nodule 32.95 10.31 294 530776 20732 62937220
Atrial fibrillation 32.81 10.31 734 530336 115902 62842050
Laryngitis 32.35 10.31 248 530822 16719 62941233
Hemiparesis 32.29 10.31 94 530976 23188 62934764
Coagulopathy 32.24 10.31 78 530992 20466 62937486
Mobility decreased 32.16 10.31 1279 529791 119880 62838072
Jaundice 31.85 10.31 131 530939 29120 62928832
Transplant rejection 31.84 10.31 26 531044 10754 62947198
Injection site swelling 31.72 10.31 567 530503 47005 62910947
Mania 31.62 10.31 34 531036 12333 62945619
Tenderness 31.52 10.31 308 530762 22270 62935682
Ventricular septal defect 31.24 10.31 94 530976 4284 62953668
Atrioventricular block complete 31.13 10.31 15 531055 8236 62949716
Panic attack 31.09 10.31 90 530980 22241 62935711
Maternal exposure before pregnancy 30.97 10.31 136 530934 7467 62950485
Irritability 30.85 10.31 148 530922 31546 62926406
Forced expiratory volume decreased 30.67 10.31 3 531067 4965 62952987
Melaena 30.61 10.31 140 530930 30225 62927727
Musculoskeletal pain 30.60 10.31 999 530071 91278 62866674
Enthesopathy 30.59 10.31 148 530922 8466 62949486
International normalised ratio increased 30.05 10.31 246 530824 46179 62911773
Joint dislocation 30.04 10.31 264 530806 18536 62939416
Nightmare 30.02 10.31 73 530997 19121 62938831
Heart rate decreased 30.02 10.31 542 530528 45018 62912934
Blood pressure diastolic increased 29.99 10.31 164 530906 9846 62948106
Pulmonary arterial hypertension 29.98 10.31 93 530977 22484 62935468
Obstructive airways disorder 29.86 10.31 82 530988 20617 62937335
Status epilepticus 29.73 10.31 51 531019 15182 62942770
Device use error 29.69 10.31 6 531064 5755 62952197
Ankylosing spondylitis 29.65 10.31 169 530901 10305 62947647
Pleural effusion 29.62 10.31 575 530495 92635 62865317
Sinus tachycardia 29.45 10.31 104 530966 24164 62933788
Substance abuse 29.42 10.31 3 531067 4804 62953148
Ischaemic stroke 29.12 10.31 67 531003 17890 62940062
Asphyxia 28.78 10.31 8 531062 6173 62951779
Dyspnoea exertional 28.77 10.31 344 530726 59958 62897994
Prescribed underdose 28.73 10.31 377 530693 29312 62928640
Tumour lysis syndrome 28.71 10.31 20 531050 8970 62948982
Haemophagocytic lymphohistiocytosis 28.55 10.31 28 531042 10599 62947353
General physical health deterioration 28.44 10.31 2003 529067 199399 62758553
Aggression 28.32 10.31 101 530969 23397 62934555
Proteinuria 28.26 10.31 75 530995 19070 62938882
Aphasia 28.25 10.31 161 530909 32839 62925113
Wheelchair user 28.04 10.31 116 530954 6203 62951749
Chronic sinusitis 27.92 10.31 40 531030 12803 62945149
Device related infection 27.89 10.31 101 530969 23291 62934661
Procedural pain 27.83 10.31 90 530980 21479 62936473
Stevens-Johnson syndrome 27.63 10.31 111 530959 24839 62933113
Latent tuberculosis 27.47 10.31 65 531005 2562 62955390
Off label use 27.47 10.31 5097 525973 669365 62288587
Metastases to lung 27.43 10.31 40 531030 12710 62945242
Cardiogenic shock 27.42 10.31 69 531001 17863 62940089
Cytopenia 27.39 10.31 34 531036 11567 62946385
Localised infection 27.34 10.31 379 530691 29831 62928121
Lymphocyte count decreased 27.34 10.31 145 530925 30112 62927840
Angina pectoris 27.25 10.31 144 530926 29934 62928018
Lupus-like syndrome 27.20 10.31 220 530850 15075 62942877
Erythema multiforme 27.08 10.31 27 531043 10142 62947810
Back pain 26.98 10.31 1874 529196 262271 62695681
Urinary retention 26.94 10.31 146 530924 30155 62927797
Limb deformity 26.76 10.31 84 530986 3918 62954034
Myoclonus 26.72 10.31 58 531012 15810 62942142
Cerebral infarction 26.65 10.31 106 530964 23787 62934165
Rash maculo-papular 26.56 10.31 157 530913 31739 62926213
Acute respiratory failure 26.52 10.31 174 530896 34311 62923641
Pain in extremity 26.40 10.31 3163 527907 328323 62629629
Small for dates baby 26.26 10.31 80 530990 3671 62954281
Muscle twitching 26.13 10.31 81 530989 19587 62938365
Haemorrhage intracranial 26.12 10.31 45 531025 13374 62944578
Chest pain 26.04 10.31 1509 529561 214450 62743502
Rhinitis allergic 26.01 10.31 36 531034 11691 62946261
Obesity 25.99 10.31 373 530697 29579 62928373
Graft versus host disease 25.97 10.31 12 531058 6751 62951201
Bradyphrenia 25.86 10.31 13 531057 6967 62950985
Dry skin 25.82 10.31 328 530742 56559 62901393
Facet joint syndrome 25.76 10.31 182 530888 11956 62945996
Pre-eclampsia 25.61 10.31 147 530923 8986 62948966
Peripheral venous disease 25.60 10.31 219 530851 15258 62942694
Paralysis 25.55 10.31 27 531043 9873 62948079
Acute myeloid leukaemia 25.44 10.31 67 531003 17080 62940872
Tachypnoea 25.37 10.31 68 531002 17234 62940718
Injection site pain 25.27 10.31 1328 529742 128472 62829480
Deep vein thrombosis 25.12 10.31 522 530548 83278 62874674
Malaise 24.99 10.31 3072 527998 412882 62545070
Temperature regulation disorder 24.95 10.31 10 531060 6122 62951830
Malignant mediastinal neoplasm 24.92 10.31 44 531026 1402 62956550
Tenosynovitis 24.85 10.31 199 530871 13596 62944356
Premature rupture of membranes 24.84 10.31 95 530975 4898 62953054
Haematoma 24.65 10.31 180 530890 34640 62923312
Fear 24.63 10.31 60 531010 15706 62942246
Diabetes mellitus 24.52 10.31 324 530746 55486 62902466
Tardive dyskinesia 24.50 10.31 21 531049 8481 62949471
Personality disorder 24.43 10.31 9 531061 5802 62952150
Paradoxical drug reaction 24.38 10.31 3 531067 4149 62953803
Lethargy 24.29 10.31 326 530744 55681 62902271
Acute graft versus host disease 24.14 10.31 4 531066 4424 62953528
Haemoptysis 24.13 10.31 141 530929 28585 62929367
Bronchopulmonary aspergillosis 24.08 10.31 22 531048 8613 62949339
Product dose omission issue 23.98 10.31 1662 529408 232651 62725301
Tenosynovitis stenosans 23.79 10.31 72 530998 3292 62954660
Clostridium difficile colitis 23.74 10.31 90 530980 20479 62937473
Smear cervix abnormal 23.67 10.31 66 531004 2880 62955072
Abdominal pain 23.60 10.31 2123 528947 291333 62666619
Lip dry 23.57 10.31 215 530855 15255 62942697
Body tinea 23.47 10.31 50 531020 1835 62956117
Acidosis 23.43 10.31 36 531034 11197 62946755
Injection site bruising 23.34 10.31 486 530584 41424 62916528
Complication of device removal 23.30 10.31 7 531063 5135 62952817
Hallucination, auditory 23.18 10.31 45 531025 12779 62945173
Retinitis 23.13 10.31 108 530962 6088 62951864
Red blood cell sedimentation rate 23.05 10.31 91 530979 4763 62953189
Dislocation of vertebra 22.93 10.31 137 530933 8498 62949454
Delirium 22.72 10.31 292 530778 50249 62907703
Neck mass 22.61 10.31 74 530996 3529 62954423
Myocarditis 22.60 10.31 32 531038 10293 62947659
Febrile bone marrow aplasia 22.48 10.31 17 531053 7308 62950644
Skin exfoliation 22.48 10.31 241 530829 42861 62915091
Synovial cyst 22.47 10.31 157 530913 10276 62947676
Rash erythematous 22.45 10.31 237 530833 42273 62915679
Breast cancer stage I 22.44 10.31 15 531055 6874 62951078
Oral herpes 22.35 10.31 324 530746 25750 62932202
Dysmorphism 22.07 10.31 55 531015 2241 62955711
Muscle rigidity 21.99 10.31 39 531031 11461 62946491
Affective disorder 21.95 10.31 12 531058 6134 62951818
Bone marrow failure 21.91 10.31 149 530921 29141 62928811
Femur fracture 21.89 10.31 480 530590 41276 62916676
Sleep apnoea syndrome 21.89 10.31 148 530922 28985 62928967
Mental disorder 21.89 10.31 127 530943 25792 62932160
Skin papilloma 21.88 10.31 91 530979 4878 62953074
Anuria 21.87 10.31 45 531025 12506 62945446
Muscle spasms 21.83 10.31 1075 529995 155075 62802877
Maternal exposure timing unspecified 21.83 10.31 117 530953 6970 62950982
Anti-cyclic citrullinated peptide antibody 21.80 10.31 113 530957 6645 62951307
Lip swelling 21.78 10.31 161 530909 30902 62927050
Multiple-drug resistance 21.75 10.31 8 531062 5162 62952790
Labelled drug-drug interaction medication error 21.72 10.31 50 531020 13349 62944603
Wound infection 21.61 10.31 274 530796 21136 62936816
Crying 21.57 10.31 111 530959 23232 62934720
Sexual dysfunction 21.53 10.31 5 531065 4354 62953598
Psychomotor hyperactivity 21.46 10.31 35 531035 10628 62947324
Rotator cuff repair 21.45 10.31 52 531018 2082 62955870
Complication of device insertion 21.42 10.31 19 531051 7545 62950407
Prescribed overdose 21.35 10.31 403 530667 33750 62924202
Swollen tongue 21.35 10.31 187 530883 34613 62923339
Hallucination, visual 21.28 10.31 86 530984 19212 62938740
Nasal polyps 21.27 10.31 12 531058 6027 62951925
Bone density decreased 21.22 10.31 201 530869 14411 62943541
Placental disorder 21.21 10.31 42 531028 1462 62956490
Glycosylated haemoglobin increased 21.14 10.31 45 531025 12353 62945599
Malignant melanoma 21.10 10.31 165 530905 11191 62946761
Skin ulcer 21.06 10.31 490 530580 42555 62915397
Synovial fluid analysis 21.04 10.31 56 531014 2377 62955575
Circulatory collapse 21.03 10.31 103 530967 21835 62936117
Body temperature decreased 20.92 10.31 261 530809 20058 62937894
Cardiomyopathy 20.91 10.31 76 530994 17508 62940444
Gastroenteritis viral 20.91 10.31 296 530774 23404 62934548
Leukocytosis 20.89 10.31 129 530941 25806 62932146
Pulmonary hypertension 20.83 10.31 204 530866 36919 62921033
Rebound effect 20.81 10.31 6 531064 4520 62953432
Hypothyroidism 20.80 10.31 242 530828 42390 62915562
Pathogen resistance 20.75 10.31 14 531056 6384 62951568
Body height below normal 20.68 10.31 52 531018 2131 62955821
Infusion site pain 20.67 10.31 72 530998 16797 62941155
Therapeutic response decreased 20.63 10.31 667 530403 60858 62897094
Nervousness 20.58 10.31 163 530907 30816 62927136
Adjustment disorder with depressed mood 20.50 10.31 151 530919 10053 62947899
Dermatitis atopic 20.44 10.31 31 531039 9693 62948259
Cough 20.43 10.31 2140 528930 290603 62667349
Toxic epidermal necrolysis 20.41 10.31 126 530944 25208 62932744
Injection site rash 20.41 10.31 244 530826 18565 62939387
Pancreatitis 20.39 10.31 288 530782 48767 62909185
Coronary artery disease 20.30 10.31 173 530897 32204 62925748
Hyperprolactinaemia 20.23 10.31 4 531066 3896 62954056
Developmental hip dysplasia 20.19 10.31 39 531031 1333 62956619
Immune reconstitution inflammatory syndrome 20.15 10.31 13 531057 6071 62951881
Acute respiratory distress syndrome 20.05 10.31 115 530955 23419 62934533
Schizoaffective disorder 19.91 10.31 3 531067 3559 62954393
Aspergillus infection 19.87 10.31 23 531047 8070 62949882
Bradypnoea 19.82 10.31 3 531067 3547 62954405
Ketoacidosis 19.77 10.31 6 531064 4372 62953580
Pseudomonas infection 19.71 10.31 40 531030 11173 62946779
Cardiotoxicity 19.64 10.31 25 531045 8413 62949539
Cyanosis 19.61 10.31 74 530996 16861 62941091
Atrioventricular block 19.58 10.31 21 531049 7626 62950326
Abdominal distension 19.54 10.31 563 530507 86052 62871900
Loose body in joint 19.47 10.31 37 531033 1249 62956703
Anhedonia 19.41 10.31 39 531031 10935 62947017
Deep vein thrombosis postoperative 19.40 10.31 162 530908 11207 62946745
Arthritis infective 19.32 10.31 106 530964 6372 62951580
Paraesthesia oral 19.28 10.31 89 530981 19167 62938785
Pericardial effusion 19.12 10.31 160 530910 29898 62928054
Exostosis 19.07 10.31 231 530839 17631 62940321
Pemphigoid 18.99 10.31 20 531050 7324 62950628
Genital haemorrhage 18.92 10.31 20 531050 7312 62950640
Vascular device infection 18.81 10.31 20 531050 7292 62950660
Erythema 18.74 10.31 1242 529828 174509 62783443
Infective pulmonary exacerbation of cystic fibrosis 18.64 10.31 28 531042 8789 62949163
Synovial disorder 18.63 10.31 48 531022 1997 62955955
Spinal stenosis 18.63 10.31 199 530871 14726 62943226
Product prescribing error 18.56 10.31 136 530934 26153 62931799
Cardiac failure acute 18.48 10.31 32 531038 9491 62948461
Memory impairment 18.47 10.31 699 530371 103559 62854393
Foetal anticonvulsant syndrome 18.42 10.31 24 531046 581 62957371
Hemiplegia 18.39 10.31 31 531039 9292 62948660
Pulmonary congestion 18.35 10.31 79 530991 17339 62940613
Hepatitis acute 18.29 10.31 30 531040 9090 62948862
Acute chest syndrome 18.22 10.31 28 531042 793 62957159
Tubulointerstitial nephritis 18.19 10.31 95 530975 19808 62938144
Rheumatoid lung 18.16 10.31 72 530998 3776 62954176
Toxic encephalopathy 18.06 10.31 17 531053 6562 62951390
Hepatic cytolysis 18.05 10.31 67 531003 15340 62942612
Clear cell renal cell carcinoma 18.04 10.31 39 531031 1446 62956506
Therapy partial responder 17.91 10.31 39 531031 10619 62947333
Fall 17.90 10.31 2946 528124 389388 62568564
Sinus bradycardia 17.90 10.31 62 531008 14489 62943463
Hallucinations, mixed 17.88 10.31 9 531061 4820 62953132
Lymphoedema 17.87 10.31 45 531025 11647 62946305
Acute myocardial infarction 17.82 10.31 177 530893 31947 62926005
Eating disorder 17.81 10.31 90 530980 18926 62939026
Paranoia 17.81 10.31 45 531025 11634 62946318
Atrial septal defect 17.74 10.31 109 530961 6829 62951123
Hyperthyroidism 17.73 10.31 63 531007 14610 62943342
Subdural haematoma 17.66 10.31 61 531009 14267 62943685
Shock haemorrhagic 17.65 10.31 35 531035 9860 62948092
Bursitis 17.62 10.31 420 530650 36621 62921331
Antinuclear antibody positive 17.60 10.31 121 530949 7878 62950074
Lymphopenia 17.59 10.31 86 530984 18241 62939711
Epstein-Barr virus infection 17.57 10.31 25 531045 8025 62949927
Graft versus host disease in gastrointestinal tract 17.51 10.31 3 531067 3238 62954714
Chills 17.35 10.31 773 530297 112605 62845347
Systemic inflammatory response syndrome 17.31 10.31 13 531057 5608 62952344
Hypervolaemia 17.29 10.31 153 530917 28260 62929692
Incorrect product administration duration 17.22 10.31 45 531025 11501 62946451
Aspiration 17.19 10.31 41 531029 10810 62947142
Product adhesion issue 17.17 10.31 9 531061 4710 62953242
Acute pulmonary oedema 17.15 10.31 26 531044 8132 62949820
Body temperature increased 17.04 10.31 214 530856 36978 62920974
Delusion 17.04 10.31 48 531022 11969 62945983
Hypophagia 17.03 10.31 173 530897 31086 62926866
Renal disorder 16.94 10.31 185 530885 32789 62925163
Eosinophil count increased 16.75 10.31 42 531028 10886 62947066
Hepatitis B reactivation 16.74 10.31 3 531067 3134 62954818
Jaundice cholestatic 16.73 10.31 22 531048 7302 62950650
Transplant dysfunction 16.71 10.31 10 531060 4862 62953090
Colitis microscopic 16.68 10.31 33 531037 9306 62948646
Hypophosphataemia 16.68 10.31 45 531025 11381 62946571
Blood potassium decreased 16.68 10.31 249 530821 41777 62916175
Skin cancer 16.63 10.31 158 530912 11337 62946615
Ileus 16.63 10.31 65 531005 14660 62943292
Salivary hypersecretion 16.54 10.31 24 531046 7642 62950310
Sensitisation 16.49 10.31 4 531066 3382 62954570
Blood glucose decreased 16.47 10.31 105 530965 20847 62937105
Multiple drug therapy 16.46 10.31 5 531065 3641 62954311
Antibody test positive 16.46 10.31 55 531015 2652 62955300
Polyhydramnios 16.43 10.31 49 531021 2222 62955730
Neutropenic colitis 16.42 10.31 3 531067 3092 62954860
Klebsiella infection 16.42 10.31 29 531041 8537 62949415
Human antichimeric antibody positive 16.42 10.31 41 531029 1673 62956279
Hepatitis cholestatic 16.40 10.31 20 531050 6858 62951094
Congenital arterial malformation 16.37 10.31 17 531053 320 62957632
Tinnitus 16.33 10.31 205 530865 35423 62922529
Renal injury 16.31 10.31 34 531036 9405 62948547
Mucosal inflammation 16.31 10.31 285 530785 46643 62911309
Polyuria 16.30 10.31 29 531041 8513 62949439
Urinary incontinence 16.29 10.31 180 530890 31834 62926118
Feeling hot 16.19 10.31 310 530760 50044 62907908
Complication associated with device 16.11 10.31 80 530990 16898 62941054
Headache 16.04 10.31 4892 526178 628349 62329603
Ear infection 16.02 10.31 426 530644 37787 62920165
Hypertransaminasaemia 15.99 10.31 19 531051 6590 62951362
Bradykinesia 15.97 10.31 12 531058 5176 62952776
Laryngospasm 15.93 10.31 3 531067 3025 62954927
Infection susceptibility increased 15.91 10.31 65 531005 3456 62954496
Generalised oedema 15.90 10.31 73 530997 15745 62942207
Dysuria 15.89 10.31 193 530877 33545 62924407
Right ventricular failure 15.73 10.31 82 530988 17106 62940846
Renal tubular necrosis 15.72 10.31 49 531021 11829 62946123
Scleritis 15.67 10.31 76 530994 4352 62953600
Product administered to patient of inappropriate age 15.65 10.31 4 531066 3264 62954688
Cushingoid 15.61 10.31 123 530947 8362 62949590
Injury 15.61 10.31 756 530314 72491 62885461
Oliguria 15.55 10.31 33 531037 9068 62948884
Subarachnoid haemorrhage 15.53 10.31 64 531006 14219 62943733
Affect lability 15.48 10.31 45 531025 11106 62946846
Acute coronary syndrome 15.46 10.31 39 531031 10087 62947865
Presyncope 15.45 10.31 153 530917 27632 62930320
Muscular weakness 15.45 10.31 851 530219 121502 62836450
Peripheral sensory neuropathy 15.42 10.31 24 531046 7427 62950525
Rectal haemorrhage 15.41 10.31 303 530767 48727 62909225
Stillbirth 15.38 10.31 103 530967 6647 62951305
Tendonitis 15.36 10.31 240 530830 19375 62938577
Bundle branch block left 15.33 10.31 22 531048 7037 62950915
Hypernatraemia 15.29 10.31 25 531045 7584 62950368
Bone lesion 15.22 10.31 16 531054 5865 62952087
Lupus vulgaris 15.22 10.31 94 530976 5900 62952052
Treatment noncompliance 15.21 10.31 220 530850 37105 62920847
Dermatitis exfoliative 15.11 10.31 14 531056 5445 62952507
Hypocalcaemia 15.09 10.31 181 530889 31532 62926420
Haematemesis 15.08 10.31 172 530898 30240 62927712
Cytomegalovirus viraemia 15.04 10.31 15 531055 5634 62952318
Proctitis 15.01 10.31 14 531056 5427 62952525
Cholecystitis chronic 14.98 10.31 41 531029 10320 62947632
Fear of injection 14.96 10.31 107 530963 7057 62950895
Pulmonary tuberculosis 14.90 10.31 76 530994 4441 62953511
Blood parathyroid hormone decreased 14.88 10.31 136 530934 9655 62948297
Dementia 14.87 10.31 94 530976 18700 62939252
Pulseless electrical activity 14.84 10.31 25 531045 7496 62950456
Middle insomnia 14.80 10.31 55 531015 12588 62945364
Postoperative wound infection 14.74 10.31 148 530922 10777 62947175
Pallor 14.72 10.31 174 530896 30394 62927558
Hyperuricaemia 14.60 10.31 14 531056 5356 62952596
Breast cancer female 14.59 10.31 61 531009 13498 62944454
Transaminases increased 14.56 10.31 180 530890 31187 62926765
Respiratory acidosis 14.51 10.31 21 531049 6694 62951258
Breast feeding 14.49 10.31 26 531044 839 62957113
Tumour marker increased 14.34 10.31 12 531058 4903 62953049
Device breakage 14.32 10.31 49 531021 11493 62946459
Granuloma skin 14.28 10.31 120 530950 8317 62949635
Carotid artery thrombosis 14.21 10.31 3 531067 2791 62955161
Coordination abnormal 14.18 10.31 63 531007 13710 62944242
Herpes zoster 14.15 10.31 834 530236 81628 62876324
Atrial tachycardia 14.13 10.31 9 531061 4231 62953721
Personality change 13.93 10.31 23 531047 6950 62951002
Oedema peripheral 13.80 10.31 1381 529689 188130 62769822
Crohn's disease 13.73 10.31 79 530991 4834 62953118
Multiple allergies 13.70 10.31 64 531006 13738 62944214
Fracture delayed union 13.66 10.31 48 531022 2374 62955578
Sleep disorder due to a general medical condition 13.64 10.31 54 531016 12134 62945818
Amylase increased 13.56 10.31 20 531050 6325 62951627
Visual acuity reduced 13.51 10.31 117 530953 21709 62936243
Injection site warmth 13.49 10.31 190 530880 15005 62942947
Wrong product administered 13.47 10.31 19 531051 6122 62951830
Hyperthermia 13.41 10.31 36 531034 9120 62948832
Electrocardiogram QRS complex prolonged 13.40 10.31 18 531052 5920 62952032
Sciatica 13.36 10.31 379 530691 33945 62924007
Inadequate analgesia 13.35 10.31 4 531066 2939 62955013
Nephropathy toxic 13.34 10.31 38 531032 9441 62948511
Device dislocation 13.29 10.31 144 530926 25561 62932391
Visual impairment 13.28 10.31 574 530496 83872 62874080
Paraesthesia 13.27 10.31 1131 529939 155835 62802117
Reversible cerebral vasoconstriction syndrome 13.23 10.31 3 531067 2655 62955297
Gastroschisis 13.22 10.31 17 531053 406 62957546
Short stature 13.21 10.31 22 531048 668 62957284
Colorectal cancer 13.19 10.31 7 531063 3638 62954314
Skin toxicity 13.16 10.31 12 531058 4702 62953250
Blood urea increased 13.15 10.31 149 530921 26230 62931722
Pulmonary haemorrhage 13.15 10.31 25 531045 7156 62950796
Autism spectrum disorder 13.13 10.31 25 531045 845 62957107
Food allergy 13.08 10.31 50 531020 11351 62946601
Ulcer 13.02 10.31 298 530772 25809 62932143
Diabetes insipidus 12.99 10.31 3 531067 2622 62955330
Respiration abnormal 12.97 10.31 21 531049 6396 62951556
Abortion incomplete 12.91 10.31 5 531065 3126 62954826
Myopathy 12.89 10.31 49 531021 11142 62946810
Pulmonary alveolar haemorrhage 12.89 10.31 12 531058 4656 62953296
Blood phosphorus decreased 12.83 10.31 11 531059 4442 62953510
Premature delivery 12.81 10.31 338 530732 29943 62928009
Anger 12.81 10.31 57 531013 12399 62945553
Post-traumatic stress disorder 12.81 10.31 15 531055 5236 62952716
Head injury 12.79 10.31 157 530913 27239 62930713
Metastases to lymph nodes 12.78 10.31 31 531039 8127 62949825
Cellulitis 12.77 10.31 822 530248 81136 62876816
Chronic graft versus host disease 12.72 10.31 5 531065 3097 62954855
Blood lactic acid increased 12.69 10.31 25 531045 7061 62950891
Intracranial pressure increased 12.68 10.31 15 531055 5212 62952740
Polydipsia 12.67 10.31 7 531063 3557 62954395
Hypoglycaemic coma 12.63 10.31 3 531067 2572 62955380
Mood altered 12.58 10.31 72 530998 14671 62943281
Neutrophilia 12.56 10.31 11 531059 4395 62953557
Joint noise 12.52 10.31 71 530999 4321 62953631
Haemorrhage in pregnancy 12.50 10.31 40 531030 1885 62956067
Dermatitis acneiform 12.48 10.31 14 531056 4982 62952970
Onychomycosis 12.47 10.31 111 530959 7821 62950131
Lymph gland infection 12.45 10.31 18 531052 482 62957470
Hypercholesterolaemia 12.41 10.31 249 530821 21085 62936867
Inhibitory drug interaction 12.41 10.31 52 531018 2797 62955155
Exomphalos 12.37 10.31 19 531051 538 62957414
Breast cancer metastatic 12.36 10.31 55 531015 11963 62945989
Impaired work ability 12.26 10.31 210 530860 17265 62940687
Product preparation error 12.25 10.31 20 531050 6072 62951880
Nasal obstruction 12.19 10.31 37 531033 1694 62956258
Plasma cell myeloma 12.18 10.31 219 530851 35686 62922266
Product substitution issue 12.15 10.31 81 530989 15915 62942037
Epistaxis 12.13 10.31 491 530579 72234 62885718
Speech disorder developmental 12.12 10.31 21 531049 659 62957293
Ankle arthroplasty 12.07 10.31 38 531032 1775 62956177
Cardiac disorder 12.05 10.31 328 530742 50488 62907464
Gestational hypertension 12.03 10.31 46 531024 2371 62955581
Multiple sclerosis 12.02 10.31 138 530932 24234 62933718
Oligoarthritis 12.01 10.31 19 531051 552 62957400
Learning disorder 12.01 10.31 21 531049 664 62957288
Congenital cerebral cyst 11.97 10.31 13 531057 258 62957694
Epilepsy 11.93 10.31 157 530913 26908 62931044
Pregnancy with contraceptive device 11.90 10.31 13 531057 4681 62953271
Talipes 11.88 10.31 34 531036 1506 62956446
Hypertelorism 11.88 10.31 17 531053 451 62957501
Fracture 11.87 10.31 230 530840 19354 62938598
Progressive multifocal leukoencephalopathy 11.81 10.31 62 531008 12909 62945043
Illness 11.80 10.31 316 530754 48743 62909209
Squamous cell carcinoma 11.68 10.31 117 530953 8515 62949437
Dactylitis 11.63 10.31 48 531022 2564 62955388
Panniculitis 11.62 10.31 146 530924 11239 62946713
Induced labour 11.58 10.31 25 531045 926 62957026
Sleep terror 11.52 10.31 4 531066 2676 62955276
Hyperbilirubinaemia 11.50 10.31 52 531018 11262 62946690
Impaired gastric emptying 11.42 10.31 46 531024 10286 62947666
Ejection fraction 11.42 10.31 3 531067 2403 62955549
Haemodynamic instability 11.41 10.31 39 531031 9151 62948801
Contrast media allergy 11.38 10.31 3 531067 2398 62955554
Tongue disorder 11.37 10.31 137 530933 10443 62947509
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.36 10.31 5 531065 2894 62955058
Abdominal pain upper 11.35 10.31 1533 529537 204911 62753041
Disturbance in social behaviour 11.34 10.31 10 531060 3983 62953969
Product physical issue 11.34 10.31 15 531055 4965 62952987
Adenovirus infection 11.33 10.31 8 531062 3563 62954389
Ingrown hair 11.29 10.31 19 531051 582 62957370
Nail injury 11.29 10.31 20 531050 639 62957313
Cyst rupture 11.24 10.31 20 531050 641 62957311
Skin plaque 11.24 10.31 34 531036 8286 62949666
Human anti-human antibody test 11.19 10.31 16 531054 424 62957528
Bacteraemia 11.19 10.31 92 530978 17256 62940696
Hypoventilation 11.15 10.31 14 531056 4740 62953212
Lymphatic fistula 11.15 10.31 22 531048 764 62957188
Hepatic necrosis 11.13 10.31 19 531051 5668 62952284
Atrial flutter 11.12 10.31 43 531027 9729 62948223
Infusion site swelling 11.11 10.31 43 531027 9727 62948225
Potentiating drug interaction 11.11 10.31 12 531058 4344 62953608
Ileus paralytic 11.10 10.31 13 531057 4538 62953414
Infusion site erythema 11.10 10.31 55 531015 11624 62946328
Infusion site pruritus 11.06 10.31 21 531049 6014 62951938
Injection site haemorrhage 11.05 10.31 274 530796 24040 62933912
Catheter site pain 11.05 10.31 14 531056 4721 62953231
Oropharyngeal pain 11.04 10.31 926 530144 93561 62864391
Trigeminal neuralgia 11.01 10.31 8 531062 3511 62954441
Cartilage injury 11.00 10.31 39 531031 1938 62956014
Incoherent 10.99 10.31 13 531057 4517 62953435
Pneumonia viral 10.97 10.31 32 531038 7890 62950062
Blood lactate dehydrogenase increased 10.97 10.31 132 530938 22984 62934968
Injection site haematoma 10.95 10.31 96 530974 6736 62951216
Cervical incompetence 10.92 10.31 19 531051 598 62957354
Mouth ulceration 10.90 10.31 357 530713 32627 62925325
Hereditary angioedema 10.88 10.31 30 531040 7532 62950420
Septic shock 10.87 10.31 451 530619 66178 62891774
Rales 10.84 10.31 62 531008 12635 62945317
Device issue 10.83 10.31 137 530933 23644 62934308
Foetal distress syndrome 10.77 10.31 30 531040 1308 62956644
Glomerular filtration rate decreased 10.75 10.31 67 531003 13374 62944578
Joint lock 10.71 10.31 43 531027 2268 62955684
Catatonia 10.70 10.31 13 531057 4464 62953488
Hepatitis fulminant 10.68 10.31 8 531062 3456 62954496
Catheter site erythema 10.66 10.31 12 531058 4264 62953688
Intervertebral disc degeneration 10.66 10.31 188 530882 15544 62942408
Endodontic procedure 10.61 10.31 54 531016 3153 62954799
Troponin increased 10.60 10.31 46 531024 10075 62947877
Terminal state 10.54 10.31 3 531067 2279 62955673
Cleft lip and palate 10.53 10.31 19 531051 616 62957336
Bronchial secretion retention 10.52 10.31 5 531065 2768 62955184
Forceps delivery 10.51 10.31 11 531059 209 62957743
Bone density increased 10.49 10.31 21 531049 737 62957215
Uterine perforation 10.49 10.31 27 531043 6936 62951016
Syndactyly 10.47 10.31 16 531054 451 62957501
Maternal exposure during breast feeding 10.45 10.31 66 531004 4175 62953777
Bundle branch block right 10.44 10.31 16 531054 4982 62952970
Neonatal respiratory distress syndrome 10.43 10.31 49 531021 2769 62955183
Drug screen positive 10.41 10.31 9 531061 3620 62954332
Cholestasis of pregnancy 10.39 10.31 28 531042 1197 62956755
Haematocrit decreased 10.36 10.31 415 530655 38925 62919027
Blood pressure inadequately controlled 10.34 10.31 16 531054 4962 62952990
Myocardial ischaemia 10.34 10.31 64 531006 12795 62945157
Osteoporotic fracture 10.31 10.31 60 531010 3686 62954266

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 550.92 10.27 830 182399 37408 34736294
Drug abuse 377.49 10.27 40 183189 99056 34674646
Toxicity to various agents 303.94 10.27 362 182867 200000 34573702
Completed suicide 277.00 10.27 85 183144 98083 34675619
Foetal exposure during pregnancy 266.83 10.27 606 182623 37495 34736207
Arthralgia 230.59 10.27 1603 181626 168438 34605264
Psoriatic arthropathy 194.25 10.27 362 182867 19436 34754266
Drug interaction 185.58 10.27 588 182641 225358 34548344
Sickle cell anaemia with crisis 141.50 10.27 138 183091 3915 34769787
Joint swelling 138.79 10.27 652 182577 59238 34714464
Dysmorphism 128.45 10.27 117 183112 3039 34770663
Intentional overdose 115.80 10.27 42 183187 43632 34730070
Psoriasis 111.65 10.27 451 182778 38361 34735341
Musculoskeletal stiffness 102.19 10.27 500 182729 46180 34727522
Acute kidney injury 97.39 10.27 1076 182153 303912 34469790
Premature baby 91.50 10.27 268 182961 19365 34754337
Blood pressure fluctuation 84.59 10.27 308 182921 24941 34748761
Enthesopathy 82.37 10.27 111 183118 4502 34769200
Product use in unapproved indication 80.82 10.27 329 182900 117170 34656532
Synovitis 79.44 10.27 206 183023 13860 34759842
Tenosynovitis 77.12 10.27 107 183122 4463 34769239
Exposure during pregnancy 76.19 10.27 154 183075 8780 34764922
Coma 75.15 10.27 77 183152 45601 34728101
Overdose 73.83 10.27 238 182991 90821 34682881
Pain 71.75 10.27 1487 181742 203188 34570514
Speech disorder developmental 71.42 10.27 72 183157 2128 34771574
Arthropathy 70.59 10.27 304 182925 26603 34747099
C-reactive protein abnormal 69.41 10.27 146 183083 8564 34765138
Suicide attempt 68.93 10.27 62 183167 39054 34734648
Drug reaction with eosinophilia and systemic symptoms 68.83 10.27 44 183185 32968 34740734
Rhabdomyolysis 64.91 10.27 165 183064 67998 34705704
Hepatic function abnormal 63.06 10.27 84 183145 44279 34729423
Death 62.89 10.27 1598 181631 396451 34377251
Foetal anticonvulsant syndrome 60.43 10.27 50 183179 1137 34772565
Neonatal respiratory distress syndrome 60.07 10.27 89 183140 3945 34769757
Febrile neutropenia 60.05 10.27 445 182784 136404 34637298
Nasopharyngitis 58.84 10.27 593 182636 69375 34704327
Maternal exposure during pregnancy 57.34 10.27 97 183132 4821 34768881
Blood pressure systolic increased 56.92 10.27 255 182974 22697 34751005
Serotonin syndrome 56.63 10.27 17 183212 19916 34753786
Hypospadias 55.60 10.27 76 183153 3125 34770577
Atrial septal defect 55.56 10.27 121 183108 7271 34766431
Alanine aminotransferase abnormal 55.37 10.27 93 183136 4595 34769107
Arthritis 55.04 10.27 316 182913 31030 34742672
Drug dependence 53.69 10.27 30 183199 24187 34749515
Low birth weight baby 52.29 10.27 123 183106 7782 34765920
Autism spectrum disorder 50.05 10.27 61 183168 2235 34771467
Maternal drugs affecting foetus 49.98 10.27 81 183148 3884 34769818
Drug resistance 49.50 10.27 38 183191 25889 34747813
Learning disorder 49.47 10.27 43 183186 1048 34772654
Cryptorchism 49.06 10.27 57 183172 1984 34771718
Peripheral swelling 48.61 10.27 614 182615 75927 34697775
Bradycardia 48.25 10.27 217 183012 75201 34698501
Hypoglycaemia neonatal 47.23 10.27 54 183175 1847 34771855
Angioedema 45.19 10.27 79 183150 37295 34736407
Small for dates baby 45.18 10.27 77 183152 3850 34769852
Disease progression 44.78 10.27 357 182872 107720 34665982
Ventricular septal defect 44.13 10.27 77 183152 3924 34769778
Rheumatoid nodule 43.86 10.27 65 183164 2882 34770820
Blood pressure systolic abnormal 43.57 10.27 76 183153 3872 34769830
Tongue disorder 43.13 10.27 90 183139 5249 34768453
Maternal exposure during breast feeding 42.10 10.27 46 183183 1495 34772207
Pain in extremity 41.29 10.27 910 182319 125603 34648099
Cardiac failure 40.82 10.27 295 182934 90953 34682749
Intentional product misuse 40.69 10.27 114 183115 45497 34728205
Syndactyly 40.61 10.27 35 183194 843 34772859
Delirium 39.95 10.27 109 183120 43882 34729820
Osteoarthritis 39.50 10.27 213 183016 20429 34753273
Joint effusion 39.02 10.27 85 183144 5108 34768594
Renal failure 39.01 10.27 467 182762 130090 34643612
Haemoglobin decreased 38.87 10.27 867 182362 119905 34653797
Drug intolerance 38.72 10.27 480 182749 59090 34714612
Cytomegalovirus infection 38.67 10.27 48 183181 26087 34747615
Blood pressure diastolic abnormal 38.67 10.27 81 183148 4737 34768965
Off label use 37.64 10.27 1807 181422 417717 34355985
Hand deformity 37.64 10.27 69 183160 3656 34770046
Blood pressure increased 37.25 10.27 659 182570 87443 34686259
Altered state of consciousness 37.18 10.27 39 183190 22854 34750848
Psychotic disorder 37.14 10.27 44 183185 24408 34749294
Multiple organ dysfunction syndrome 36.98 10.27 242 182987 76324 34697378
Respiratory arrest 36.97 10.27 56 183173 27987 34745715
Palmar-plantar erythrodysaesthesia syndrome 36.95 10.27 21 183208 16774 34756928
Developmental delay 36.77 10.27 58 183171 2717 34770985
Depressed level of consciousness 36.09 10.27 110 183119 42731 34730971
Foot deformity 36.09 10.27 76 183153 4461 34769241
Blood pressure diastolic decreased 35.74 10.27 117 183112 8977 34764725
Poisoning 35.52 10.27 10 183219 12216 34761486
Heart rate decreased 35.34 10.27 286 182943 31459 34742243
Basal cell carcinoma 35.05 10.27 199 183030 19459 34754243
Sedation 35.01 10.27 35 183194 20971 34752731
Pulmonary fibrosis 34.64 10.27 189 183040 18207 34755495
Suicidal ideation 34.53 10.27 103 183126 40285 34733417
Talipes 33.92 10.27 46 183183 1877 34771825
Infusion related reaction 33.83 10.27 426 182803 52631 34721071
Exposure via breast milk 33.82 10.27 47 183182 1963 34771739
Tendonitis 33.62 10.27 115 183114 9025 34764677
Joint laxity 33.57 10.27 23 183206 389 34773313
C-reactive protein increased 33.07 10.27 431 182798 53667 34720035
Lower respiratory tract infection 33.07 10.27 281 182948 31356 34742346
Lactic acidosis 32.45 10.27 85 183144 34687 34739015
Grip strength decreased 32.40 10.27 59 183170 3110 34770592
Weight decreased 32.24 10.27 1178 182051 175123 34598579
Knee arthroplasty 32.21 10.27 99 183130 7345 34766357
Pancytopenia 32.16 10.27 688 182541 94469 34679233
Immune reconstitution inflammatory syndrome 32.15 10.27 4 183225 8755 34764947
Somnolence 31.10 10.27 403 182826 110713 34662989
Pathogen resistance 31.02 10.27 6 183223 9476 34764226
Renal impairment 31.00 10.27 331 182898 94182 34679520
Red blood cell sedimentation rate increased 30.88 10.27 112 183117 9050 34764652
Musculoskeletal pain 30.36 10.27 278 182951 31685 34742017
Cardiac arrest 30.25 10.27 340 182889 95819 34677883
Congenital hand malformation 30.16 10.27 25 183204 570 34773132
Plagiocephaly 29.82 10.27 24 183205 524 34773178
Hyperglycaemia 29.39 10.27 107 183122 39373 34734329
Acute hepatic failure 29.00 10.27 19 183210 14055 34759647
Hypermobility syndrome 28.85 10.27 20 183209 345 34773357
Shock 28.43 10.27 52 183177 24127 34749575
Caesarean section 28.36 10.27 45 183184 2119 34771583
Jaundice neonatal 28.11 10.27 35 183194 1311 34772391
Agitation 27.93 10.27 181 183048 57218 34716484
Dysgraphia 27.85 10.27 46 183183 2241 34771461
Drug withdrawal syndrome 27.73 10.27 38 183191 19796 34753906
Neuroleptic malignant syndrome 27.53 10.27 32 183197 17902 34755800
Hypoglycaemia 27.25 10.27 171 183058 54469 34719233
Polyarthritis 27.20 10.27 68 183161 4472 34769230
Foetal growth restriction 27.16 10.27 64 183165 4053 34769649
Astigmatism 26.98 10.27 31 183198 1066 34772636
Language disorder 26.97 10.27 45 183184 2211 34771491
Acute chest syndrome 26.72 10.27 27 183202 800 34772902
Intellectual disability 26.69 10.27 34 183195 1304 34772398
Intentional self-injury 26.52 10.27 20 183209 13751 34759951
Fatigue 26.42 10.27 2270 180959 368383 34405319
Finger deformity 26.39 10.27 36 183193 1477 34772225
Diaphragmatic disorder 26.38 10.27 33 183196 1242 34772460
Rash maculo-papular 26.20 10.27 70 183159 28381 34745321
Wound 26.19 10.27 150 183079 14714 34758988
Large for dates baby 26.13 10.27 28 183201 890 34772812
Colitis ulcerative 25.46 10.27 161 183068 16359 34757343
Substance abuse 24.65 10.27 5 183224 7636 34766066
Anal fistula 24.48 10.27 73 183156 5326 34768376
Blood creatine phosphokinase increased 24.15 10.27 137 183092 44720 34728982
Hepatic failure 24.14 10.27 96 183133 34435 34739267
Body temperature decreased 23.93 10.27 133 183096 12901 34760801
Hydrops foetalis 23.90 10.27 26 183203 841 34772861
Ankylosing spondylitis 23.75 10.27 74 183155 5530 34768172
Respiratory failure 23.75 10.27 413 182816 108159 34665543
Neurotoxicity 23.71 10.27 36 183193 17974 34755728
Hypotonia neonatal 23.46 10.27 32 183197 1313 34772389
Ultrasound antenatal screen 23.39 10.27 21 183208 535 34773167
Oropharyngeal pain 23.08 10.27 286 182943 35199 34738503
Skin cancer 23.02 10.27 111 183118 10186 34763516
Inflammation 22.90 10.27 238 182991 28057 34745645
Haematocrit decreased 22.86 10.27 264 182965 31952 34741750
Blood pressure diastolic increased 22.84 10.27 68 183161 4957 34768745
Respiratory depression 22.83 10.27 31 183198 16214 34757488
Hyperbilirubinaemia neonatal 22.52 10.27 24 183205 758 34772944
Vitamin D deficiency 22.46 10.27 81 183148 6527 34767175
Venoocclusive liver disease 22.26 10.27 7 183222 7959 34765743
Selective eating disorder 21.97 10.27 36 183193 1742 34771960
Knee deformity 21.94 10.27 22 183207 646 34773056
Motor developmental delay 21.94 10.27 22 183207 646 34773056
Anaphylactic shock 21.83 10.27 31 183198 15910 34757792
Tuberculosis 21.79 10.27 96 183133 8481 34765221
Therapeutic product effect decreased 21.73 10.27 278 182951 34465 34739237
Otitis media 21.57 10.27 47 183182 2825 34770877
Drug withdrawal syndrome neonatal 21.47 10.27 54 183175 3565 34770137
Dyspraxia 21.40 10.27 18 183211 419 34773283
Radiation inflammation 21.30 10.27 25 183204 880 34772822
Ear infection 21.24 10.27 108 183121 10123 34763579
Nasal disorder 21.13 10.27 37 183192 1891 34771811
Trisomy 18 21.04 10.27 23 183206 748 34772954
Cholestasis 20.75 10.27 72 183157 26876 34746826
Joint stiffness 20.67 10.27 112 183117 10761 34762941
Ear disorder 20.59 10.27 34 183195 1656 34772046
Post procedural infection 20.47 10.27 64 183165 4792 34768910
Arthritis infective 20.26 10.27 51 183178 3368 34770334
Hydrocele 20.26 10.27 38 183191 2049 34771653
Electrocardiogram QT prolonged 19.99 10.27 129 183100 40823 34732879
Drug ineffective for unapproved indication 19.89 10.27 61 183168 23654 34750048
Localised infection 19.87 10.27 159 183070 17428 34756274
Wrong technique in product usage process 19.86 10.27 109 183120 35877 34737825
Foetal disorder 19.74 10.27 23 183206 803 34772899
Back disorder 19.68 10.27 78 183151 6573 34767129
Cleft lip and palate 19.51 10.27 24 183205 888 34772814
Agranulocytosis 19.47 10.27 62 183167 23759 34749943
Joint range of motion decreased 19.47 10.27 83 183146 7229 34766473
Tachycardia 19.34 10.27 320 182909 84452 34689250
Infection 19.24 10.27 618 182611 90297 34683405
Congenital foot malformation 19.20 10.27 17 183212 425 34773277
Sinusitis 19.04 10.27 314 182915 41088 34732614
Crohn's disease 19.00 10.27 47 183182 3070 34770632
Dyslexia 18.97 10.27 15 183214 319 34773383
Malignant neoplasm progression 18.91 10.27 336 182893 87710 34685992
Loss of personal independence in daily activities 18.89 10.27 261 182968 32918 34740784
Red blood cell sedimentation rate 18.84 10.27 27 183202 1161 34772541
Respiratory disorder neonatal 18.80 10.27 32 183197 1598 34772104
Influenza 18.71 10.27 365 182864 49301 34724401
Strabismus 18.68 10.27 33 183196 1698 34772004
Toxic epidermal necrolysis 18.64 10.27 55 183174 21591 34752111
Limb reduction defect 18.56 10.27 14 183215 277 34773425
Anal fissure 18.51 10.27 57 183172 4233 34769469
Blood parathyroid hormone decreased 18.34 10.27 30 183199 1450 34772252
Umbilical hernia 18.22 10.27 60 183169 4617 34769085
Serum ferritin increased 18.13 10.27 72 183157 6074 34767628
Cerebral haemorrhage 18.11 10.27 108 183121 34829 34738873
Akathisia 18.04 10.27 10 183219 8099 34765603
Poor venous access 18.01 10.27 64 183165 5119 34768583
Malignant melanoma 17.93 10.27 87 183142 8003 34765699
Proteinuria 17.83 10.27 45 183184 18597 34755105
Stevens-Johnson syndrome 17.82 10.27 45 183184 18594 34755108
Juvenile idiopathic arthritis 17.75 10.27 34 183195 1863 34771839
Sleep disorder due to a general medical condition 17.74 10.27 3 183226 5218 34768484
Arthritis bacterial 17.70 10.27 63 183166 5043 34768659
Medical device implantation 17.65 10.27 19 183210 607 34773095
Aspergillus infection 17.61 10.27 23 183206 12231 34761471
Cellulitis 17.60 10.27 382 182847 52569 34721133
Agitation neonatal 17.51 10.27 25 183204 1071 34772631
Multiple congenital abnormalities 17.47 10.27 18 183211 546 34773156
Granuloma skin 17.32 10.27 27 183202 1252 34772450
Metabolic acidosis 17.28 10.27 146 183083 43534 34730168
Gastrointestinal infection 17.16 10.27 68 183161 5730 34767972
Attention deficit hyperactivity disorder 17.12 10.27 40 183189 2519 34771183
Hypertelorism 17.00 10.27 18 183211 564 34773138
Spinal disorder 16.97 10.27 55 183174 4197 34769505
Congenital anomaly 16.94 10.27 28 183201 1365 34772337
Lung neoplasm malignant 16.87 10.27 152 183077 17243 34756459
Lacrimal disorder 16.79 10.27 14 183215 322 34773380
Cleft lip 16.75 10.27 14 183215 323 34773379
Congenital bladder anomaly 16.70 10.27 13 183216 270 34773432
Immunodeficiency 16.69 10.27 65 183164 5433 34768269
Weight decrease neonatal 16.68 10.27 14 183215 325 34773377
Fall 16.57 10.27 1256 181973 201629 34572073
No adverse event 16.50 10.27 63 183166 22864 34750838
Aggression 16.44 10.27 128 183101 38836 34734866
Drug level increased 16.37 10.27 60 183169 22036 34751666
Disseminated intravascular coagulation 16.32 10.27 59 183170 21757 34751945
Withdrawal syndrome 16.29 10.27 25 183204 12430 34761272
Pectus excavatum 16.23 10.27 12 183217 230 34773472
Pyrexia 16.23 10.27 1514 181715 331499 34442203
Ankyloglossia congenital 16.15 10.27 13 183216 284 34773418
Renal aplasia 16.13 10.27 20 183209 746 34772956
Synovial cyst 16.08 10.27 37 183192 2307 34771395
Latent tuberculosis 16.04 10.27 27 183202 1336 34772366
Hepatocellular injury 16.00 10.27 61 183168 22150 34751552
Haematochezia 15.88 10.27 337 182892 46197 34727505
Second primary malignancy 15.78 10.27 11 183218 7875 34765827
Osteonecrosis of jaw 15.74 10.27 45 183184 17844 34755858
Joint ankylosis 15.73 10.27 29 183200 1543 34772159
Cardio-respiratory arrest 15.62 10.27 200 183029 55073 34718629
Colorectal cancer 15.60 10.27 3 183226 4758 34768944
Suspected suicide 15.54 10.27 3 183226 4745 34768957
Ventricular tachycardia 15.51 10.27 79 183150 26500 34747202
Abdominal discomfort 15.45 10.27 417 182812 59418 34714284
Hyperammonaemia 15.44 10.27 7 183222 6360 34767342
C-reactive protein decreased 15.30 10.27 33 183196 1969 34771733
Upper respiratory tract infection 15.30 10.27 251 182978 32808 34740894
Microcephaly 15.22 10.27 20 183209 791 34772911
Sexual dysfunction 15.18 10.27 7 183222 6296 34767406
Haemangioma congenital 15.10 10.27 16 183213 502 34773200
Nephrolithiasis 15.06 10.27 233 182996 30100 34743602
Skin injury 14.98 10.27 36 183193 2309 34771393
Patent ductus arteriosus 14.88 10.27 45 183184 3309 34770393
Behaviour disorder 14.87 10.27 58 183171 4852 34768850
Scoliosis 14.85 10.27 40 183189 2753 34770949
Anti-cyclic citrullinated peptide antibody positive 14.81 10.27 31 183198 1812 34771890
Arthrodesis 14.78 10.27 15 183214 447 34773255
Abortion spontaneous 14.68 10.27 14 183215 386 34773316
Acute graft versus host disease 14.49 10.27 8 183221 6495 34767207
Injection site pain 14.47 10.27 286 182943 38719 34734983
Respiratory rate increased 14.37 10.27 95 183134 9799 34763903
Oesophageal fibrosis 14.26 10.27 10 183219 176 34773526
Weight increased 14.25 10.27 610 182619 92423 34681279
Electrocardiogram QRS complex prolonged 14.22 10.27 4 183225 4890 34768812
Hernia pain 14.21 10.27 12 183217 281 34773421
Hypokalaemia 14.19 10.27 217 183012 57997 34715705
Kidney infection 14.18 10.27 61 183168 5333 34768369
Arnold-Chiari malformation 14.16 10.27 13 183216 341 34773361
Cystitis haemorrhagic 14.16 10.27 6 183223 5673 34768029
Bone cyst 14.14 10.27 28 183201 1572 34772130
Fistula discharge 14.11 10.27 20 183209 851 34772851
Maternal exposure before pregnancy 14.07 10.27 19 183210 772 34772930
Blood test abnormal 14.06 10.27 73 183156 6898 34766804
Tooth malformation 14.02 10.27 10 183219 181 34773521
Neck mass 13.99 10.27 28 183201 1585 34772117
Bradycardia neonatal 13.77 10.27 21 183208 955 34772747
Heart rate irregular 13.77 10.27 135 183094 15672 34758030
Melaena 13.67 10.27 119 183110 35261 34738441
Hepatic enzyme increased 13.65 10.27 284 182945 38796 34734906
Nerve compression 13.62 10.27 43 183186 3236 34770466
Developmental coordination disorder 13.56 10.27 10 183219 191 34773511
Bronchiolitis 13.52 10.27 42 183187 3134 34770568
Autoscopy 13.45 10.27 11 183218 246 34773456
Septic arthritis staphylococcal 13.40 10.27 15 183214 501 34773201
Diverticular perforation 13.33 10.27 44 183185 3390 34770312
Gamma-glutamyltransferase increased 13.30 10.27 94 183135 29137 34744565
Maternal exposure timing unspecified 13.29 10.27 13 183216 370 34773332
Foetal heart rate deceleration abnormality 13.28 10.27 15 183214 506 34773196
Foetal distress syndrome 13.23 10.27 22 183207 1078 34772624
Panniculitis 13.16 10.27 31 183198 1963 34771739
Acute respiratory distress syndrome 13.08 10.27 81 183148 25888 34747814
Hepatitis E antibody positive 13.08 10.27 11 183218 256 34773446
Haemangioma 13.07 10.27 30 183199 1867 34771835
Hypertriglyceridaemia 13.05 10.27 15 183214 8433 34765269
Oxygen saturation decreased 13.03 10.27 372 182857 53446 34720256
Vomiting 13.03 10.27 1119 182110 246502 34527200
Polydactyly 12.93 10.27 23 183206 1190 34772512
BK virus infection 12.87 10.27 7 183222 5731 34767971
Acute generalised exanthematous pustulosis 12.84 10.27 10 183219 6766 34766936
Low set ears 12.81 10.27 14 183215 455 34773247
Nodule 12.80 10.27 70 183159 6749 34766953
Pleuritic pain 12.54 10.27 44 183185 3497 34770205
Vitamin B12 deficiency 12.52 10.27 48 183181 3983 34769719
Abnormal behaviour 12.52 10.27 78 183151 24891 34748811
Cardiotoxicity 12.51 10.27 7 183222 5641 34768061
Red blood cell count decreased 12.42 10.27 218 183011 28872 34744830
Adenovirus infection 12.41 10.27 6 183223 5251 34768451
Educational problem 12.36 10.27 15 183214 547 34773155
Respiratory tract infection viral 12.34 10.27 35 183194 2482 34771220
Headache 12.30 10.27 1216 182013 199419 34574283
Myoclonus 12.26 10.27 38 183191 14687 34759015
Vascular insufficiency 12.26 10.27 12 183217 342 34773360
Hyperthermia 12.21 10.27 23 183206 10554 34763148
Red blood cell sedimentation rate abnormal 12.20 10.27 44 183185 3545 34770157
Loss of consciousness 12.13 10.27 335 182894 82332 34691370
Inguinal hernia 12.11 10.27 75 183154 7566 34766136
Blood insulin increased 12.09 10.27 12 183217 348 34773354
Bronchopulmonary aspergillosis 12.09 10.27 38 183191 14621 34759081
Anal atresia 12.03 10.27 11 183218 287 34773415
Fistula 12.03 10.27 69 183160 6771 34766931
Pleural fibrosis 12.02 10.27 24 183205 1356 34772346
Glycosylated haemoglobin increased 12.00 10.27 26 183203 11334 34762368
Hepatitis E virus test positive 12.00 10.27 11 183218 288 34773414
Chronic graft versus host disease 11.94 10.27 4 183225 4369 34769333
Neck pain 11.93 10.27 193 183036 25156 34748546
Therapy partial responder 11.92 10.27 20 183209 9596 34764106
Hallucination 11.87 10.27 194 183035 51304 34722398
Spina bifida 11.84 10.27 12 183217 357 34773345
Psychomotor retardation 11.78 10.27 44 183185 3606 34770096
Hypermetropia 11.77 10.27 14 183215 500 34773202
Pneumonia 11.67 10.27 2114 181115 360513 34413189
Abdominal adhesions 11.64 10.27 25 183204 1488 34772214
Hypocalcaemia 11.60 10.27 77 183152 24212 34749490
Mania 11.59 10.27 20 183209 9491 34764211
Ear malformation 11.57 10.27 11 183218 302 34773400
Urticaria 11.57 10.27 244 182985 62133 34711569
Rheumatoid lung 11.54 10.27 19 183210 923 34772779
Nail pitting 11.51 10.27 11 183218 304 34773398
Thrombotic microangiopathy 11.51 10.27 24 183205 10606 34763096
Product quality issue 11.50 10.27 48 183181 16987 34756715
Pharyngeal disorder 11.50 10.27 17 183212 752 34772950
Nail bed bleeding 11.46 10.27 12 183217 371 34773331
Diabetic ketoacidosis 11.45 10.27 52 183177 17980 34755722
Irritability 11.43 10.27 79 183150 24611 34749091
Transplant rejection 11.40 10.27 23 183206 10288 34763414
Gangrene neonatal 11.36 10.27 9 183220 192 34773510
Skin abrasion 11.36 10.27 70 183159 7049 34766653
Palindromic rheumatism 11.32 10.27 9 183220 193 34773509
Hallucination, auditory 11.22 10.27 29 183200 11888 34761814
Posterior reversible encephalopathy syndrome 11.18 10.27 22 183207 9932 34763770
Joint instability 11.18 10.27 13 183216 453 34773249
Necrotising fasciitis streptococcal 11.06 10.27 8 183221 148 34773554
Contusion 11.03 10.27 259 182970 36105 34737597
Neutropenia neonatal 11.02 10.27 16 183213 696 34773006
Vitamin B complex deficiency 10.98 10.27 12 183217 390 34773312
Hypertransaminasaemia 10.98 10.27 8 183221 5598 34768104
Unresponsive to stimuli 10.97 10.27 92 183137 27477 34746225
Gross motor delay 10.91 10.27 11 183218 325 34773377
Pulmonary alveolar haemorrhage 10.90 10.27 14 183215 7498 34766204
Mobility decreased 10.87 10.27 220 183009 29908 34743794
Hypotension 10.87 10.27 1007 182222 220642 34553060
Excessive cerumen production 10.86 10.27 11 183218 327 34773375
Obsessive-compulsive disorder 10.82 10.27 8 183221 5556 34768146
Hepatitis 10.81 10.27 77 183152 23827 34749875
Fine motor skill dysfunction 10.81 10.27 27 183202 1775 34771927
Peripheral artery thrombosis 10.79 10.27 32 183197 2328 34771374
Pharyngitis 10.78 10.27 75 183154 7869 34765833
Acute graft versus host disease in skin 10.75 10.27 7 183222 5194 34768508
Congenital genital malformation 10.71 10.27 8 183221 156 34773546
Asphyxia 10.70 10.27 12 183217 6823 34766879
Exposure to toxic agent 10.69 10.27 3 183226 3672 34770030
Congenital hydronephrosis 10.67 10.27 16 183213 717 34772985
Eosinophilia 10.67 10.27 87 183142 26135 34747567
Peritoneal dialysis complication 10.66 10.27 26 183203 1683 34772019
Cardiac murmur 10.64 10.27 74 183155 7763 34765939
Neonatal infection 10.62 10.27 12 183217 405 34773297
Back pain 10.61 10.27 758 182471 121031 34652671
Progressive multifocal leukoencephalopathy 10.61 10.27 22 183207 9742 34763960
Brain oedema 10.59 10.27 37 183192 13784 34759918
Visuospatial deficit 10.55 10.27 7 183222 112 34773590
Muscle twitching 10.53 10.27 24 183205 10274 34763428
Abdominal pain 10.51 10.27 995 182234 162623 34611079
Dystonia 10.51 10.27 26 183203 10819 34762883
Personality change 10.51 10.27 7 183222 5132 34768570
Pulmonary artery stenosis congenital 10.42 10.27 13 183216 488 34773214
Blood folate increased 10.39 10.27 10 183219 279 34773423
Neonatal seizure 10.36 10.27 13 183216 491 34773211
Gastroschisis 10.33 10.27 8 183221 165 34773537
Cholelithiasis 10.32 10.27 162 183067 20986 34752716
Pulmonary pain 10.32 10.27 21 183208 1203 34772499
Meningeal disorder 10.31 10.27 11 183218 348 34773354
Pneumonia aspiration 10.28 10.27 156 183073 41747 34731955

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1219.58 9.99 3649 539514 204821 78996404
Completed suicide 1169.13 9.99 148 543015 245619 78955606
Toxicity to various agents 1019.99 9.99 826 542337 420714 78780511
Arthropathy 968.08 9.99 3028 540135 174083 79027142
Pemphigus 946.63 9.99 2094 541069 97488 79103737
Systemic lupus erythematosus 943.06 9.99 2356 540807 118793 79082432
Joint swelling 928.37 9.99 4160 539003 284486 78916739
Hand deformity 918.55 9.99 2123 541040 101796 79099429
Synovitis 890.95 9.99 2649 540514 148085 79053140
Glossodynia 825.68 9.99 2030 541133 101307 79099918
Drug abuse 770.96 9.99 99 543064 162592 79038633
Arthralgia 734.85 9.99 6509 536654 565294 78635931
Anti-cyclic citrullinated peptide antibody positive 705.60 9.99 1672 541491 81471 79119754
Wound 691.29 9.99 2047 541116 114132 79087093
Maternal exposure during pregnancy 651.85 9.99 2230 540933 134308 79066917
Pericarditis 634.85 9.99 1852 541311 102384 79098841
Infusion related reaction 625.97 9.99 3162 540001 227075 78974150
Abdominal discomfort 584.59 9.99 3301 539862 247426 78953799
Drug interaction 566.31 9.99 1242 541921 413941 78787284
Pain 546.90 9.99 7246 535917 696556 78504669
Swelling 527.60 9.99 2887 540276 213824 78987401
Discomfort 523.01 9.99 1962 541201 123655 79077570
Alopecia 511.14 9.99 3003 540160 228352 78972873
Therapeutic product effect decreased 506.08 9.99 2335 540828 161528 79039697
Contraindicated product administered 450.14 9.99 2195 540968 155343 79045882
Duodenal ulcer perforation 445.64 9.99 1220 541943 64991 79136234
Musculoskeletal stiffness 443.81 9.99 2358 540805 172650 79028575
Helicobacter infection 442.21 9.99 1257 541906 68447 79132778
Rheumatoid factor positive 424.25 9.99 1124 542039 58715 79142510
Intentional overdose 420.50 9.99 102 543061 105858 79095367
Death 406.18 9.99 2234 540929 564280 78636945
Drug intolerance 405.71 9.99 3133 540030 260986 78940239
Nasopharyngitis 403.64 9.99 3036 540127 250845 78950380
Psoriatic arthropathy 385.30 9.99 1289 541874 76710 79124515
Hepatic enzyme increased 378.04 9.99 2331 540832 180279 79020946
Acute kidney injury 362.53 9.99 2066 541097 517338 78683887
Febrile neutropenia 336.46 9.99 665 542498 230334 78970891
Exposure during pregnancy 311.94 9.99 1441 541722 99691 79101534
Impaired healing 294.40 9.99 1281 541882 86374 79114851
Overdose 266.71 9.99 532 542631 183674 79017551
Peripheral swelling 260.61 9.99 2896 540267 266721 78934504
Hypersensitivity 258.16 9.99 2827 540336 259412 78941813
Cardiac arrest 256.99 9.99 488 542675 171608 79029617
Depressed level of consciousness 255.68 9.99 172 542991 96480 79104745
Suicide attempt 248.51 9.99 127 543036 82805 79118420
Sinusitis 247.53 9.99 2221 540942 193280 79007945
C-reactive protein abnormal 247.46 9.99 809 542354 47558 79153667
Muscle injury 245.54 9.99 809 542354 47752 79153473
Folliculitis 243.76 9.99 881 542282 54499 79146726
Treatment failure 241.09 9.99 1985 541178 168501 79032724
Irritable bowel syndrome 235.89 9.99 944 542219 61297 79139928
Lower respiratory tract infection 230.34 9.99 1589 541574 127631 79073594
Blister 220.58 9.99 1482 541681 117994 79083231
Sleep disorder due to general medical condition, insomnia type 216.09 9.99 721 542442 42835 79158390
Red blood cell sedimentation rate abnormal 214.04 9.99 454 542709 20509 79180716
Sickle cell anaemia with crisis 210.75 9.99 265 542898 7657 79193568
Arthritis 209.69 9.99 1421 541742 113459 79087766
Knee arthroplasty 208.46 9.99 709 542454 42539 79158686
Bradycardia 208.01 9.99 378 542785 135179 79066046
Weight increased 206.87 9.99 2838 540325 274548 78926677
Rhabdomyolysis 204.91 9.99 240 542923 102891 79098334
Product use issue 204.59 9.99 2258 540905 207564 78993661
Drug reaction with eosinophilia and systemic symptoms 199.12 9.99 94 543069 64150 79137075
Osteoarthritis 190.98 9.99 1131 542032 86178 79115047
Hip arthroplasty 189.17 9.99 605 542558 35151 79166074
Blood pressure fluctuation 188.33 9.99 931 542232 66214 79135011
Sedation 181.90 9.99 63 543100 51832 79149393
Respiratory arrest 175.62 9.99 86 543077 57464 79143761
Renal failure 174.06 9.99 740 542423 200228 79000997
Lactic acidosis 172.05 9.99 136 543027 70223 79131002
Contusion 168.12 9.99 1650 541513 147126 79054099
Cardiac failure 167.93 9.99 519 542644 154323 79046902
Malignant neoplasm progression 166.52 9.99 430 542733 135560 79065665
Disease progression 166.43 9.99 668 542495 183694 79017531
Hepatic function abnormal 163.34 9.99 154 543009 72953 79128272
Rheumatic fever 162.30 9.99 495 542668 28030 79173195
Sopor 161.43 9.99 18 543145 32992 79168233
Neutropenia 155.42 9.99 1234 541929 286476 78914749
Fatigue 151.87 9.99 7760 535403 921967 78279258
Coma 151.43 9.99 284 542879 100365 79100860
Fibromyalgia 148.20 9.99 845 542318 63495 79137730
Infection 144.33 9.99 2381 540782 239331 78961894
Serotonin syndrome 142.46 9.99 64 543099 44963 79156262
Pregnancy 140.83 9.99 453 542710 26398 79174827
Psoriasis 140.21 9.99 1068 542095 88519 79112706
Abortion spontaneous 137.19 9.99 478 542685 29029 79172196
Multiple organ dysfunction syndrome 136.88 9.99 394 542769 119852 79081373
Ill-defined disorder 136.82 9.99 842 542321 65033 79136192
Swollen joint count increased 135.28 9.99 403 542760 22524 79178701
Blood pressure systolic increased 135.25 9.99 850 542313 66136 79135089
Drug resistance 135.13 9.99 59 543104 42154 79159071
Blood pressure systolic abnormal 133.57 9.99 335 542828 16912 79184313
Red blood cell sedimentation rate increased 133.10 9.99 643 542520 45299 79155926
Blood pressure diastolic abnormal 132.32 9.99 357 542806 18845 79182380
Hyponatraemia 130.48 9.99 695 542468 177153 79024072
Respiratory failure 129.40 9.99 713 542450 180198 79021027
Agitation 129.34 9.99 306 542857 99409 79101816
Cardio-respiratory arrest 129.11 9.99 348 542815 108162 79093063
Renal impairment 128.13 9.99 595 542568 157188 79044037
Condition aggravated 125.15 9.99 4375 538788 496749 78704476
Hypoglycaemia 124.55 9.99 321 542842 101273 79099952
Hypotension 124.02 9.99 2181 540982 438136 78763089
Joint effusion 122.21 9.99 333 542830 17681 79183544
Cytomegalovirus infection 120.90 9.99 70 543093 42574 79158651
Electrocardiogram QT prolonged 120.75 9.99 273 542890 90113 79111112
Intentional product misuse 118.73 9.99 298 542865 94867 79106358
Hepatic failure 117.80 9.99 146 543017 61066 79140159
Rash 116.17 9.99 4930 538233 573428 78627797
Somnolence 115.12 9.99 1056 542107 237925 78963300
Drug dependence 114.06 9.99 68 543095 40701 79160524
Product use in unapproved indication 110.57 9.99 1130 542033 249229 78951996
Constipation 110.15 9.99 1315 541848 281735 78919490
Grip strength decreased 109.34 9.99 363 542800 21506 79179719
Intentional self-injury 109.14 9.99 42 543121 32377 79168848
Neoplasm progression 108.42 9.99 115 543048 51567 79149658
Hyperglycaemia 107.97 9.99 196 542967 70139 79131086
Altered state of consciousness 106.76 9.99 85 543078 43737 79157488
Inflammation 106.46 9.99 1041 542122 92712 79108513
Pain in extremity 104.12 9.99 3234 539929 361304 78839921
Angioedema 102.92 9.99 228 542935 75807 79125418
Poisoning 102.86 9.99 23 543140 25249 79175976
Tachycardia 102.75 9.99 748 542415 177020 79024205
C-reactive protein increased 102.17 9.99 1335 541828 127692 79073533
Thrombocytopenia 100.67 9.99 1239 541924 264020 78937205
Metabolic acidosis 98.69 9.99 264 542899 82265 79118960
Stomatitis 98.67 9.99 1475 541688 145282 79055943
Injection site erythema 98.65 9.99 888 542275 77309 79123916
Musculoskeletal pain 95.79 9.99 1093 542070 101261 79099964
Enthesopathy 95.75 9.99 231 542932 11377 79189848
Blood pressure diastolic decreased 95.66 9.99 434 542729 29782 79171443
Osteoporosis 95.51 9.99 664 542499 53448 79147777
Blood cholesterol increased 95.25 9.99 930 542233 82790 79118435
Respiratory depression 94.34 9.99 35 543128 27595 79173630
Rheumatoid nodule 92.18 9.99 295 542868 17143 79184082
Foot deformity 91.88 9.99 366 542797 23708 79177517
Disability assessment scale score increased 89.33 9.99 114 543049 3344 79197881
Shock 89.02 9.99 99 543064 43449 79157776
Disseminated intravascular coagulation 87.97 9.99 69 543094 35773 79165452
Gastrointestinal disorder 87.57 9.99 1242 541921 120963 79080262
Hyperhidrosis 85.83 9.99 641 542522 150851 79050374
Live birth 84.85 9.99 301 542862 18443 79182782
Cholestasis 84.73 9.99 140 543023 51969 79149256
Bone erosion 84.60 9.99 291 542872 17556 79183669
Heart rate decreased 82.40 9.99 786 542377 69530 79131695
Tenosynovitis 81.19 9.99 262 542901 15292 79185933
Blood creatine phosphokinase increased 80.85 9.99 209 542954 65881 79135344
Intentional product use issue 80.84 9.99 1471 541692 150641 79050584
Drug ineffective 80.71 9.99 8471 534692 1072442 78128783
Juvenile idiopathic arthritis 80.14 9.99 128 543035 4635 79196590
Hepatocellular injury 79.14 9.99 126 543037 47467 79153758
Injection site reaction 78.48 9.99 640 542523 54145 79147080
Joint range of motion decreased 77.87 9.99 439 542724 32843 79168382
Hyperkalaemia 76.86 9.99 460 542703 113938 79087287
Joint stiffness 76.82 9.99 509 542654 40321 79160904
Ventricular tachycardia 75.58 9.99 105 543058 41830 79159395
Injection site pruritus 74.71 9.99 519 542644 41764 79159461
Polyarthritis 73.43 9.99 216 542947 11986 79189239
Cerebral haemorrhage 73.18 9.99 179 542984 57494 79143731
Sedation complication 73.06 9.99 10 543153 15659 79185566
Syncope 72.73 9.99 826 542337 178623 79022602
Palmar-plantar erythrodysaesthesia syndrome 72.60 9.99 71 543092 33063 79168162
Cognitive disorder 72.54 9.99 239 542924 69687 79131538
Anaphylactic shock 72.30 9.99 83 543080 35913 79165312
Encephalopathy 71.55 9.99 228 542935 67169 79134056
Joint destruction 70.81 9.99 137 543026 5788 79195437
Neuroleptic malignant syndrome 70.27 9.99 51 543112 27508 79173717
Anaemia 69.55 9.99 2407 540756 442608 78758617
Hypoxia 69.43 9.99 415 542748 102828 79098397
Caesarean section 68.95 9.99 215 542948 12320 79188905
Loss of personal independence in daily activities 68.92 9.99 1031 542132 101549 79099676
Injection site pain 68.42 9.99 1254 541909 128584 79072641
Acute hepatic failure 67.76 9.99 63 543100 30050 79171175
Neurotoxicity 67.49 9.99 73 543090 32445 79168780
Leukopenia 66.94 9.99 491 542672 116022 79085203
Localised infection 66.85 9.99 462 542701 37113 79164112
Pulmonary fibrosis 66.28 9.99 521 542642 43591 79157634
Basal cell carcinoma 65.59 9.99 458 542705 36917 79164308
Drug withdrawal syndrome 64.53 9.99 85 543078 34633 79166592
Seizure 64.28 9.99 902 542261 187932 79013293
Myocardial infarction 63.22 9.99 878 542285 183251 79017974
Cardiac failure congestive 63.12 9.99 642 542521 141760 79059465
Drug ineffective for unapproved indication 62.70 9.99 162 543001 51076 79150149
Mobility decreased 61.95 9.99 1173 541990 121002 79080223
Joint laxity 61.70 9.99 78 543085 2266 79198959
Hallucination 61.23 9.99 338 542825 85407 79115818
Neuropathy peripheral 60.61 9.99 642 542521 140663 79060562
Blood pressure diastolic increased 60.32 9.99 227 542936 14315 79186910
Agranulocytosis 60.14 9.99 136 543027 44894 79156331
Blood pressure increased 59.43 9.99 1872 541291 209488 78991737
Orthostatic hypotension 58.92 9.99 191 542972 55973 79145252
Hypothermia 58.12 9.99 42 543121 22704 79178521
Vomiting 57.69 9.99 3834 539329 661994 78539231
Mydriasis 57.52 9.99 24 543139 17619 79183606
Cytokine release syndrome 57.34 9.99 98 543065 35900 79165325
Gestational diabetes 57.11 9.99 130 543033 6163 79195062
Injection site swelling 56.78 9.99 530 542633 46602 79154623
Disturbance in attention 56.66 9.99 168 542995 50633 79150592
Disability 56.52 9.99 249 542914 16871 79184354
Tendonitis 56.19 9.99 315 542848 23515 79177710
Psychotic disorder 56.14 9.99 124 543039 41278 79159947
Venoocclusive liver disease 56.11 9.99 7 543156 11764 79189461
Nodule 55.59 9.99 306 542857 22688 79178537
Immune reconstitution inflammatory syndrome 55.53 9.99 13 543150 13828 79187397
Abnormal behaviour 55.44 9.99 102 543061 36319 79164906
Hypokalaemia 55.27 9.99 671 542492 143369 79057856
Tremor 54.54 9.99 822 542341 169261 79031964
Adverse event 54.08 9.99 638 542525 59576 79141649
Red blood cell sedimentation rate 53.91 9.99 118 543045 5447 79195778
Type 2 diabetes mellitus 53.88 9.99 611 542552 56511 79144714
Drug level increased 53.57 9.99 119 543044 39532 79161693
Neutrophil count decreased 53.47 9.99 397 542766 93562 79107663
Cerebral infarction 53.18 9.99 148 543015 45528 79155697
Tongue disorder 52.96 9.99 212 542951 13763 79187462
Inappropriate antidiuretic hormone secretion 52.50 9.99 61 543102 26252 79174973
Restlessness 51.68 9.99 154 543009 46338 79154887
Sepsis 51.64 9.99 1418 541745 268010 78933215
Disorientation 51.36 9.99 236 542927 62540 79138685
Delirium 51.35 9.99 351 542812 84276 79116949
Body temperature decreased 51.27 9.99 385 542778 31760 79169465
Second primary malignancy 51.01 9.99 17 543146 14333 79186892
Pathogen resistance 50.97 9.99 17 543146 14325 79186900
Substance abuse 50.82 9.99 6 543157 10520 79190705
Aspergillus infection 50.79 9.99 34 543129 19127 79182098
Gamma-glutamyltransferase increased 50.65 9.99 196 542967 54484 79146741
Alanine aminotransferase abnormal 50.55 9.99 154 543009 8713 79192512
Posterior reversible encephalopathy syndrome 50.23 9.99 63 543100 26218 79175007
Myoclonus 50.11 9.99 69 543094 27591 79173634
Ejection fraction decreased 49.87 9.99 100 543063 34477 79166748
Diabetic ketoacidosis 49.80 9.99 98 543065 34024 79167201
Respiratory distress 49.73 9.99 216 542947 58123 79143102
Extrapyramidal disorder 49.22 9.99 49 543114 22630 79178595
Suicidal ideation 49.17 9.99 311 542852 76029 79125196
Blood creatinine increased 49.16 9.99 751 542412 154306 79046919
Miosis 49.08 9.99 23 543140 15766 79185459
Creatinine renal clearance decreased 48.66 9.99 35 543128 18967 79182258
Ear infection 48.65 9.99 401 542762 34031 79167194
Oropharyngeal pain 48.14 9.99 1028 542135 108325 79092900
Melaena 48.00 9.99 232 542931 60658 79140567
Torsade de pointes 47.62 9.99 37 543126 19275 79181950
Dehydration 47.10 9.99 1308 541855 246879 78954346
Myalgia 47.02 9.99 936 542227 184705 79016520
Laryngitis 46.82 9.99 225 542938 15814 79185411
Thrombotic microangiopathy 46.81 9.99 41 543122 20128 79181097
No adverse event 46.74 9.99 116 543047 37076 79164149
Akathisia 46.63 9.99 16 543147 13243 79187982
Injection site bruising 46.39 9.99 455 542708 40547 79160678
Rash maculo-papular 46.37 9.99 210 542953 55868 79145357
Aggression 46.34 9.99 184 542979 50774 79150451
Blood glucose increased 45.88 9.99 531 542632 114444 79086781
Acute respiratory distress syndrome 45.44 9.99 151 543012 43916 79157309
Bronchopulmonary aspergillosis 45.22 9.99 51 543112 22243 79178982
Proteinuria 45.18 9.99 96 543067 32406 79168819
Asphyxia 45.09 9.99 12 543151 11708 79189517
Oral herpes 45.03 9.99 331 542832 27123 79174102
Eosinophilia 44.97 9.99 158 543005 45187 79156038
Brain oedema 44.79 9.99 64 543099 25199 79176026
Femur fracture 44.75 9.99 431 542732 38221 79163004
Withdrawal syndrome 44.73 9.99 71 543092 26783 79174442
Haematotoxicity 44.67 9.99 25 543138 15494 79185731
Latent tuberculosis 44.39 9.99 81 543082 3272 79197953
Synovial cyst 44.17 9.99 160 543003 9905 79191320
Drug use disorder 44.17 9.99 4 543159 8647 79192578
Tenderness 44.03 9.99 294 542869 23348 79177877
Irritability 43.80 9.99 139 543024 41005 79160220
Loss of consciousness 43.68 9.99 843 542320 167100 79034125
Cardiogenic shock 43.64 9.99 143 543020 41771 79159454
Dyspnoea 43.63 9.99 5142 538021 851883 78349342
Speech disorder 43.17 9.99 207 542956 54238 79146987
Myelosuppression 42.99 9.99 136 543027 40160 79161065
Bursitis 42.64 9.99 402 542761 35442 79165783
Exposure to toxic agent 42.33 9.99 6 543157 9152 79192073
Transplant rejection 42.18 9.99 42 543121 19395 79181830
Osteonecrosis of jaw 41.95 9.99 152 543011 43074 79158151
Acute graft versus host disease 41.89 9.99 9 543154 10158 79191067
Blood parathyroid hormone decreased 41.67 9.99 162 543001 10374 79190851
Unresponsive to stimuli 41.44 9.99 217 542946 55571 79145654
Dystonia 41.21 9.99 51 543112 21348 79179877
Atrial fibrillation 41.20 9.99 1029 542134 196857 79004368
Herpes zoster 40.95 9.99 875 542288 92208 79109017
Unintentional medical device removal 40.94 9.99 3 543160 7709 79193516
Ascites 40.76 9.99 324 542839 75238 79125987
Wrong technique in product usage process 40.68 9.99 315 542848 73560 79127665
Neck deformity 40.44 9.99 56 543107 1781 79199444
Coagulopathy 40.21 9.99 119 543044 35887 79165338
Tumour lysis syndrome 40.16 9.99 63 543100 23876 79177349
Fracture 39.94 9.99 270 542893 21531 79179694
Ventricular fibrillation 39.79 9.99 100 543063 31826 79169399
Acute chest syndrome 39.60 9.99 51 543112 1510 79199715
Arrhythmia 39.26 9.99 250 542913 61022 79140203
Coronary artery disease 39.01 9.99 273 542890 65201 79136024
Anaphylactic reaction 39 9.99 373 542790 83370 79117855
Acute generalised exanthematous pustulosis 38.94 9.99 36 543127 17218 79184007
Ischaemic stroke 38.83 9.99 107 543056 33024 79168201
Granuloma skin 38.71 9.99 144 543019 9030 79192195
Exostosis 38.54 9.99 221 542942 16637 79184588
Lip dry 38.50 9.99 207 542956 15211 79186014
Skin ulcer 38.23 9.99 549 542614 53601 79147624
Maternal exposure before pregnancy 38.21 9.99 89 543074 4284 79196941
Psychomotor hyperactivity 38.21 9.99 35 543128 16814 79184411
Vision blurred 38.12 9.99 500 542663 105398 79095827
Haemophagocytic lymphohistiocytosis 38.04 9.99 56 543107 21781 79179444
Tuberculosis 37.92 9.99 204 542959 14994 79186231
Facet joint syndrome 37.78 9.99 165 542998 11137 79190088
Ankylosing spondylitis 37.66 9.99 174 542989 12031 79189194
Joint injury 37.56 9.99 352 542811 30983 79170242
Pre-eclampsia 37.11 9.99 119 543044 6922 79194303
Toxic skin eruption 37.08 9.99 59 543104 22234 79178991
Therapeutic response decreased 37.08 9.99 651 542512 66202 79135023
Hyperthermia 36.87 9.99 41 543122 17996 79183229
Pancreatitis acute 36.81 9.99 193 542970 49411 79151814
Haemorrhage intracranial 36.72 9.99 77 543086 26116 79175109
Accidental overdose 36.58 9.99 142 543021 39439 79161786
Clostridium difficile colitis 36.56 9.99 106 543057 32177 79169048
Multiple fractures 36.43 9.99 129 543034 7897 79193328
Wheelchair user 36.37 9.99 108 543055 6024 79195201
Peripheral venous disease 36.00 9.99 208 542955 15701 79185524
BK virus infection 35.85 9.99 8 543155 8796 79192429
Nausea 35.84 9.99 5852 537311 951344 78249881
Neck mass 35.64 9.99 87 543076 4317 79196908
Dyskinesia 35.63 9.99 170 542993 44603 79156622
Status epilepticus 35.62 9.99 73 543090 24968 79176257
Dysarthria 35.54 9.99 292 542871 67330 79133895
Joint dislocation 35.46 9.99 217 542946 16722 79184503
Injection site rash 35.10 9.99 226 542937 17728 79183497
Arthritis infective 35.05 9.99 130 543033 8141 79193084
Fear of injection 34.67 9.99 121 543042 7353 79193872
Mania 34.66 9.99 44 543119 18216 79183009
Off label use 34.66 9.99 5540 537623 901675 78299550
Tachypnoea 34.35 9.99 108 543055 31955 79169270
Maternal exposure timing unspecified 34.35 9.99 102 543061 5690 79195535
Asthenia 34.34 9.99 3009 540154 508680 78692545
Panniculitis 34.29 9.99 171 542992 12200 79189025
Forced expiratory volume decreased 34.13 9.99 6 543157 7808 79193417
Pyrexia 34.11 9.99 4075 539088 674634 78526591
Bronchospasm 34.08 9.99 74 543089 24785 79176440
Balance disorder 34.05 9.99 471 542692 98386 79102839
Premature labour 34 9.99 130 543033 8260 79192965
Gastroenteritis viral 33.91 9.99 287 542876 24544 79176681
Mental status changes 33.90 9.99 292 542871 66667 79134558
Pulmonary oedema 33.89 9.99 411 542752 87843 79113382
Bradyphrenia 33.85 9.99 15 543148 10625 79190600
Ulcer 33.61 9.99 332 542831 29640 79171585
Limb deformity 33.51 9.99 75 543088 3515 79197710
Spinal stenosis 33.51 9.99 203 542960 15588 79185637
Stevens-Johnson syndrome 33.39 9.99 145 543018 39021 79162204
Smear cervix abnormal 33.24 9.99 61 543102 2475 79198750
Anxiety 33.23 9.99 1369 541794 247143 78954082
Acidosis 33.15 9.99 52 543111 19710 79181515
Erythema multiforme 33.02 9.99 43 543120 17608 79183617
Colorectal cancer 32.99 9.99 9 543154 8638 79192587
Blood bilirubin increased 32.57 9.99 291 542872 65941 79135284
Premature rupture of membranes 32.52 9.99 80 543083 3989 79197236
Premature delivery 32.45 9.99 272 542891 23195 79178030
Deep vein thrombosis postoperative 32.23 9.99 152 543011 10600 79190625
Stress cardiomyopathy 32.12 9.99 18 543145 11148 79190077
Graft versus host disease 32 9.99 33 543130 14993 79186232
Chronic kidney disease 31.94 9.99 292 542871 65862 79135363
Lupus-like syndrome 31.90 9.99 182 542981 13675 79187550
Toxic epidermal necrolysis 31.68 9.99 176 542987 44405 79156820
Sciatica 31.62 9.99 356 542807 32866 79168359
Gastrointestinal haemorrhage 31.59 9.99 765 542398 146954 79054271
Face oedema 31.41 9.99 93 543070 28043 79173182
Retinitis 31.23 9.99 97 543066 5546 79195679
Rotator cuff repair 31.11 9.99 50 543113 1820 79199405
Bone disorder 31.09 9.99 230 542933 18883 79182342
Poor venous access 31.02 9.99 221 542942 17928 79183297
Asthma 31.02 9.99 692 542471 134403 79066822
Malignant mediastinal neoplasm 30.95 9.99 43 543120 1372 79199853
Anti-cyclic citrullinated peptide antibody 30.93 9.99 99 543064 5753 79195472
Disease recurrence 30.87 9.99 175 542988 43934 79157291
Influenza 30.85 9.99 1126 542037 128480 79072745
Haemoptysis 30.72 9.99 239 542924 55760 79145465
Angina pectoris 30.67 9.99 216 542947 51516 79149709
Adjustment disorder with depressed mood 30.64 9.99 133 543030 8953 79192272
Skin papilloma 30.59 9.99 99 543064 5787 79195438
Jaundice 30.54 9.99 225 542938 53124 79148101
Fear 30.51 9.99 65 543098 21921 79179304
Leukocytosis 30.10 9.99 173 542990 43282 79157943
Scleritis 30.02 9.99 81 543082 4275 79196950
Wound infection 30.02 9.99 272 542891 23719 79177506
Blood alkaline phosphatase increased 29.88 9.99 283 542880 63381 79137844
Bone density decreased 29.87 9.99 174 542989 13173 79188052
Shock haemorrhagic 29.81 9.99 57 543106 20003 79181222
Platelet count decreased 29.62 9.99 1056 542107 193608 79007617
Drug tolerance decreased 29.58 9.99 170 542993 12808 79188417
Blood calcium decreased 29.50 9.99 114 543049 31705 79169520
Cytopenia 29.35 9.99 59 543104 20324 79180901
Interstitial lung disease 29.33 9.99 565 542598 112035 79089190
Urinary retention 28.65 9.99 247 542916 56383 79144842
Hallucination, visual 28.61 9.99 120 543043 32609 79168616
Skin cancer 28.59 9.99 188 542975 14852 79186373
Foot fracture 28.42 9.99 251 542912 21730 79179495
Tenosynovitis stenosans 28.39 9.99 64 543099 3014 79198211
Emotional distress 28.29 9.99 158 543005 39811 79161414
Hypomagnesaemia 28.24 9.99 195 542968 46716 79154509
Hepatitis B reactivation 28.24 9.99 4 543159 6104 79195121
Pulmonary alveolar haemorrhage 28.19 9.99 22 543141 11435 79189790
Hallucination, auditory 28.04 9.99 62 543101 20631 79180594
Obesity 28.02 9.99 364 542799 34761 79166464
Septic shock 27.91 9.99 630 542533 122171 79079054
Dislocation of vertebra 27.85 9.99 117 543046 7763 79193462
Acute myeloid leukaemia 27.78 9.99 112 543051 30773 79170452
Aphasia 27.77 9.99 195 542968 46537 79154688
Pneumatosis intestinalis 27.75 9.99 5 543158 6392 79194833
Sinus tachycardia 27.73 9.99 143 543020 36765 79164460
Klebsiella infection 27.69 9.99 40 543123 15680 79185545
Synovial fluid analysis 27.53 9.99 54 543109 2305 79198920
Cerebrovascular accident 27.52 9.99 826 542337 154466 79046759
Cytomegalovirus viraemia 27.48 9.99 28 543135 12793 79188432
Anuria 27.43 9.99 64 543099 20899 79180326
Acute graft versus host disease in skin 27.35 9.99 9 543154 7649 79193576
Diarrhoea 27.32 9.99 5437 537726 875052 78326173
Lymphocyte count decreased 27.28 9.99 199 542964 47090 79154135
Polyneuropathy 26.84 9.99 80 543083 24071 79177154
Hypertransaminasaemia 26.76 9.99 25 543138 11899 79189326
Adenovirus infection 26.73 9.99 12 543151 8435 79192790
Glycosylated haemoglobin increased 26.68 9.99 57 543106 19203 79182022
Metastases to bone 26.37 9.99 82 543081 24345 79176880
Rheumatoid lung 26.36 9.99 76 543087 4169 79197056
Hemiplegia 26.33 9.99 38 543125 14901 79186324
Sexual dysfunction 26.22 9.99 10 543153 7753 79193472
Mouth ulceration 26.21 9.99 387 542776 38007 79163218
Pulmonary embolism 26.15 9.99 931 542232 170723 79030502
Liver injury 26.14 9.99 536 542627 56078 79145147
Muscle twitching 26.12 9.99 84 543079 24680 79176545
Haemorrhage 25.99 9.99 450 542713 90668 79110557
Pemphigoid 25.98 9.99 40 543123 15275 79185950
Hyperbilirubinaemia 25.98 9.99 83 543080 24435 79176790
Bronchitis 25.94 9.99 1113 542050 129531 79071694
Subdural haematoma 25.81 9.99 118 543045 31316 79169909
Chest discomfort 25.78 9.99 729 542434 137315 79063910
Dysphagia 25.70 9.99 634 542529 121502 79079723
Labelled drug-drug interaction medication error 25.67 9.99 99 543064 27551 79173674
Device difficult to use 25.67 9.99 32 543131 13353 79187872
Nocardiosis 25.61 9.99 4 543159 5675 79195550
Hepatotoxicity 25.52 9.99 225 542938 51127 79150098
Acute myocardial infarction 25.48 9.99 370 542793 76666 79124559
Antinuclear antibody positive 25.48 9.99 114 543049 7776 79193449
Metastases to liver 25.26 9.99 103 543060 28211 79173014
Diabetes insipidus 25.25 9.99 3 543160 5234 79195991
Hyperammonaemia 25.20 9.99 23 543140 11070 79190155
Electrocardiogram QRS complex prolonged 25.17 9.99 22 543141 10811 79190414
Hyperuricaemia 25.03 9.99 26 543137 11773 79189452
Muscle rigidity 24.99 9.99 62 543101 19820 79181405
Rhinorrhoea 24.95 9.99 687 542476 75387 79125838
Rebound effect 24.93 9.99 9 543154 7217 79194008
Loose body in joint 24.87 9.99 37 543126 1258 79199967
Immunodeficiency 24.84 9.99 242 542921 21526 79179699
Dermatitis acneiform 24.82 9.99 19 543144 9974 79191251
Body tinea 24.81 9.99 45 543118 1809 79199416
Cystitis haemorrhagic 24.68 9.99 16 543147 9156 79192069
Weight decreased 24.65 9.99 2772 540391 352426 78848799
Temperature regulation disorder 24.49 9.99 5 543158 5848 79195377
Infection susceptibility increased 24.46 9.99 68 543095 3653 79197572
Blood pressure decreased 24.43 9.99 504 542659 98962 79102263
Malignant melanoma 24.33 9.99 178 542985 14563 79186662
Chronic graft versus host disease 24.16 9.99 8 543155 6773 79194452
Product quality issue 24.11 9.99 134 543029 33806 79167419
Hemiparesis 24.06 9.99 133 543030 33600 79167625
Synovial disorder 23.88 9.99 46 543117 1937 79199288
Breast cancer stage I 23.71 9.99 8 543155 6692 79194533
Ileus 23.60 9.99 95 543068 26116 79175109
Joint noise 23.58 9.99 70 543093 3904 79197321
Product administration error 23.58 9.99 124 543039 31722 79169503
Multiple sclerosis relapse 23.52 9.99 203 542960 46330 79154895
Pancreatitis 23.51 9.99 327 542836 68248 79132977
Cyanosis 23.49 9.99 90 543073 25092 79176133
Cellulitis 23.45 9.99 937 542226 108123 79093102
Injection site warmth 23.42 9.99 177 542986 14630 79186595
Finger deformity 23.39 9.99 107 543056 7367 79193858
Myocardial ischaemia 23.29 9.99 92 543071 25427 79175798
Accidental exposure to product 23.17 9.99 122 543041 31200 79170025
Peripheral sensory neuropathy 23.12 9.99 33 543130 13000 79188225
Febrile bone marrow aplasia 23.06 9.99 33 543130 12987 79188238
Hyperlactacidaemia 22.96 9.99 5 543158 5590 79195635
Haematoma 22.83 9.99 236 542927 51959 79149266
Acute coronary syndrome 22.77 9.99 71 543092 21062 79180163
Cardiotoxicity 22.71 9.99 30 543133 12209 79189016
Device use error 22.61 9.99 10 543153 7091 79194134
Impaired work ability 22.55 9.99 219 542944 19462 79181763
Haematocrit decreased 22.52 9.99 562 542601 60750 79140475
Tubulointerstitial nephritis 22.49 9.99 160 543003 38075 79163150
Nephropathy toxic 22.43 9.99 68 543095 20351 79180874
Pulmonary arterial hypertension 22.40 9.99 108 543055 28258 79172967
Cardiac failure acute 22.28 9.99 61 543102 18868 79182357
Hyperthyroidism 22.28 9.99 77 543086 22132 79179093
Hydrops foetalis 22.26 9.99 27 543136 751 79200474
White blood cell count decreased 22.13 9.99 1052 542111 187236 79013989
Pancytopenia 22.04 9.99 1359 541804 164386 79036839
Cardiac failure chronic 22.01 9.99 26 543137 11109 79190116
Compartment syndrome 21.98 9.99 4 543159 5078 79196147
Blood lactic acid increased 21.89 9.99 33 543130 12711 79188514
Fracture delayed union 21.89 9.99 46 543117 2064 79199161
Pleuritic pain 21.85 9.99 131 543032 10021 79191204
Hyperprolactinaemia 21.76 9.99 3 543160 4673 79196552
Affective disorder 21.73 9.99 15 543148 8304 79192921
Decreased appetite 21.71 9.99 2022 541141 340396 78860829
Tardive dyskinesia 21.64 9.99 24 543139 10547 79190678
Potentiating drug interaction 21.61 9.99 17 543146 8802 79192423
Multiple-drug resistance 21.56 9.99 17 543146 8791 79192434
Product prescribing error 21.55 9.99 198 542965 44615 79156610
Hypernatraemia 21.53 9.99 41 543122 14410 79186815
Hepatitis acute 21.52 9.99 46 543117 15496 79185729
Hepatic encephalopathy 21.50 9.99 88 543075 24078 79177147
Acute respiratory failure 21.47 9.99 281 542882 59260 79141965
Ultrasound antenatal screen 21.40 9.99 25 543138 668 79200557
Cardiomyopathy 21.33 9.99 112 543051 28662 79172563
Lower limb fracture 21.30 9.99 247 542916 22968 79178257
Pseudomonas infection 21.29 9.99 72 543091 20831 79180394
Cleft lip and palate 21.25 9.99 25 543138 673 79200552
Haemoglobin decreased 21.24 9.99 1773 541390 220346 78980879
Sinus bradycardia 21.20 9.99 94 543069 25153 79176072
Oliguria 21.18 9.99 50 543113 16259 79184966
Venoocclusive disease 21.13 9.99 3 543160 4570 79196655
Vertigo 21.07 9.99 337 542826 68745 79132480
Oxygen saturation decreased 21.04 9.99 1078 542085 127969 79073256
Human antichimeric antibody positive 20.92 9.99 39 543124 1602 79199623
Hepatitis cholestatic 20.90 9.99 39 543124 13813 79187412
Injection site haemorrhage 20.65 9.99 285 542878 27585 79173640
Metastases to central nervous system 20.63 9.99 51 543112 16324 79184901
Autoimmune disorder 20.61 9.99 188 542975 16424 79184801
Epstein-Barr virus infection 20.53 9.99 42 543121 14374 79186851
Therapy partial responder 20.53 9.99 56 543107 17341 79183884
Haemodynamic instability 20.47 9.99 56 543107 17326 79183899
Infective pulmonary exacerbation of cystic fibrosis 20.45 9.99 35 543128 12816 79188409
Respiratory disorder 20.37 9.99 201 542962 44655 79156570
Polyuria 20.33 9.99 45 543118 14969 79186256
Post procedural infection 20.26 9.99 140 543023 11244 79189981
Graft versus host disease in skin 20.22 9.99 8 543155 6065 79195160
General physical health deterioration 20.19 9.99 2156 541007 273082 78928143
Hypocalcaemia 20.13 9.99 230 542933 49694 79151531
Injury 20.10 9.99 680 542483 76816 79124409
Ingrown hair 20.05 9.99 25 543138 716 79200509
Pulmonary haemorrhage 20.02 9.99 44 543119 14673 79186552
Cyst 19.99 9.99 162 543001 13678 79187547
Atrioventricular block 19.91 9.99 41 543122 14000 79187225
Anhedonia 19.89 9.99 45 543118 14853 79186372
Urticaria 19.78 9.99 1045 542118 184156 79017069
Jaundice cholestatic 19.60 9.99 29 543134 11255 79189970
Lip swelling 19.57 9.99 181 542982 40730 79160495
Pulseless electrical activity 19.54 9.99 42 543121 14118 79187107
Bacteraemia 19.48 9.99 137 543026 32687 79168538
Postoperative wound infection 19.42 9.99 153 543010 12808 79188417
Mental disorder 19.40 9.99 129 543034 31173 79170052
Bladder cancer 19.39 9.99 68 543095 19458 79181767
Drug tolerance 19.36 9.99 113 543050 8562 79192663
Body height below normal 19.29 9.99 43 543120 2010 79199215
Respiratory acidosis 19.24 9.99 29 543134 11171 79190054
Ankle arthroplasty 19.13 9.99 36 543127 1489 79199736
Parkinsonism 19.11 9.99 54 543109 16530 79184695
Hepatitis fulminant 19.09 9.99 13 543150 7249 79193976
Haematemesis 19.09 9.99 246 542917 52018 79149207
Pleural effusion 19.03 9.99 802 542361 144460 79056765
Endophthalmitis 19.02 9.99 10 543153 6418 79194807
Pneumonia aspiration 19.01 9.99 331 542832 66636 79134589
Catatonia 18.91 9.99 19 543144 8737 79192488
Lymphopenia 18.90 9.99 126 543037 30431 79170794
Transplant dysfunction 18.89 9.99 13 543150 7208 79194017
Trisomy 18 18.85 9.99 22 543141 587 79200638
Myocarditis 18.80 9.99 80 543083 21653 79179572
Virologic failure 18.79 9.99 3 543160 4188 79197037
Eosinophil count increased 18.76 9.99 57 543106 17048 79184177
Atrial tachycardia 18.45 9.99 13 543150 7120 79194105
Polyhydramnios 18.43 9.99 38 543125 1682 79199543
Pruritus genital 18.42 9.99 4 543159 4482 79196743
Toxic encephalopathy 18.35 9.99 31 543132 11409 79189816
Flushing 18.35 9.99 459 542704 87809 79113416
Sleep terror 18.26 9.99 4 543159 4454 79196771
Glomerular filtration rate decreased 18.18 9.99 86 543077 22616 79178609
Procedural pain 18.16 9.99 88 543075 22996 79178229
Renal injury 18.15 9.99 57 543106 16870 79184355
Surgery 18.14 9.99 319 542844 32447 79168778
Multiple drug therapy 18.10 9.99 3 543160 4075 79197150
Hypoalbuminaemia 18.06 9.99 79 543084 21218 79180007
Cushingoid 17.92 9.99 119 543044 9433 79191792
Hepatocellular carcinoma 17.90 9.99 21 543142 9000 79192225
Foot operation 17.89 9.99 82 543081 5651 79195574
Palpitations 17.87 9.99 693 542470 125917 79075308
Generalised tonic-clonic seizure 17.82 9.99 202 542961 43708 79157517
Oesophageal carcinoma 17.81 9.99 30 543133 11054 79190171
Personality change 17.80 9.99 26 543137 10144 79191081
Skin necrosis 17.75 9.99 195 542968 17892 79183333
Progressive multifocal leukoencephalopathy 17.72 9.99 76 543087 20524 79180701
Normal newborn 17.69 9.99 95 543068 6977 79194248
Heparin-induced thrombocytopenia 17.69 9.99 24 543139 9658 79191567
Heart rate irregular 17.68 9.99 317 542846 32362 79168863
Enterocolitis 17.66 9.99 46 543117 14466 79186759
Pulmonary congestion 17.65 9.99 110 543053 26990 79174235
Breast feeding 17.65 9.99 23 543140 689 79200536
Red blood cell count decreased 17.64 9.99 515 542648 56998 79144227
Cytomegalovirus infection reactivation 17.61 9.99 20 543143 8696 79192529
Device related infection 17.60 9.99 149 543014 34145 79167080
Cholangitis 17.54 9.99 38 543125 12738 79188487
Short stature 17.53 9.99 23 543140 694 79200531
International normalised ratio increased 17.49 9.99 441 542722 84280 79116945
Immune effector cell-associated neurotoxicity syndrome 17.45 9.99 9 543154 5839 79195386
Onychomycosis 17.40 9.99 106 543057 8155 79193070
Gastric haemorrhage 17.34 9.99 49 543114 15001 79186224
Dizziness 17.34 9.99 3240 539923 523201 78678024
Foetal distress syndrome 17.32 9.99 19 543144 473 79200752
Accidental death 17.27 9.99 4 543159 4287 79196938
Rhinitis allergic 17.25 9.99 36 543127 12233 79188992
Aspartate aminotransferase increased 17.21 9.99 770 542393 137871 79063354
Hypoaesthesia 17.20 9.99 1432 541731 177920 79023305
Hypothyroidism 17.20 9.99 252 542911 52140 79149085
Subarachnoid haemorrhage 17.16 9.99 97 543066 24368 79176857
Ventricular arrhythmia 17.09 9.99 21 543142 8819 79192406
Bradypnoea 17.06 9.99 10 543153 6042 79195183
Musculoskeletal disorder 16.99 9.99 222 542941 21226 79179999
Placental disorder 16.99 9.99 26 543137 907 79200318
Prescribed overdose 16.94 9.99 357 542806 37526 79163699
Endodontic procedure 16.93 9.99 49 543114 2694 79198531
Left ventricular dysfunction 16.92 9.99 71 543092 19290 79181935
Obstructive airways disorder 16.91 9.99 135 543028 31324 79169901
Nasal polyps 16.88 9.99 15 543148 7312 79193913
Hypoxic-ischaemic encephalopathy 16.85 9.99 17 543146 7803 79193422
Rash pruritic 16.72 9.99 621 542542 71008 79130217
Acute pulmonary oedema 16.64 9.99 46 543117 14184 79187041
Bone pain 16.64 9.99 273 542890 55469 79145756
Delusion 16.57 9.99 77 543086 20346 79180879
Paranoia 16.52 9.99 72 543091 19360 79181865
Maternal exposure during breast feeding 16.47 9.99 49 543114 2736 79198489
Hepatic cancer 16.46 9.99 29 543134 10500 79190725
Ileus paralytic 16.44 9.99 25 543138 9595 79191630
Upper respiratory tract infection 16.41 9.99 769 542394 90399 79110826
Antibody test positive 16.40 9.99 49 543114 2743 79198482
Colitis ulcerative 16.39 9.99 330 542833 34412 79166813
COVID-19 pneumonia 16.36 9.99 122 543041 28727 79172498
Hydrocephalus 16.32 9.99 22 543141 8878 79192347
Nightmare 16.32 9.99 106 543057 25755 79175470
Metastases to lung 16.25 9.99 66 543097 18097 79183128
Knee operation 16.20 9.99 81 543082 5785 79195440
Radiation inflammation 16.17 9.99 25 543138 880 79200345
Device leakage 16.00 9.99 31 543132 10825 79190400
Transaminases increased 15.92 9.99 252 542911 51491 79149734
Fluid retention 15.90 9.99 358 542805 69451 79131774
Cross sensitivity reaction 15.89 9.99 3 543160 3709 79197516
Paralysis 15.86 9.99 42 543121 13135 79188090
Therapy non-responder 15.85 9.99 775 542388 91530 79109695
Injection site urticaria 15.83 9.99 145 543018 12681 79188544
Disturbance in social behaviour 15.82 9.99 7 543156 4963 79196262
Stillbirth 15.80 9.99 61 543102 3894 79197331
Osteopenia 15.79 9.99 193 542970 18171 79183054
Pharyngitis streptococcal 15.79 9.99 126 543037 10588 79190637
Dysgeusia 15.78 9.99 284 542879 56893 79144332
Sickle cell anaemia 15.77 9.99 21 543142 643 79200582
Atrioventricular block complete 15.73 9.99 59 543104 16551 79184674
Diaphragmatic disorder 15.71 9.99 36 543127 1714 79199511
Hepatic cirrhosis 15.63 9.99 329 542834 34577 79166648
Respiration abnormal 15.59 9.99 18 543145 7770 79193455
Cataract 15.59 9.99 543 542620 61577 79139648
Cytomegalovirus chorioretinitis 15.58 9.99 9 543154 5481 79195744
Hypercapnia 15.48 9.99 23 543140 8912 79192313
Induced labour 15.45 9.99 24 543139 848 79200377
End stage renal disease 15.44 9.99 38 543125 12182 79189043
Coordination abnormal 15.43 9.99 63 543100 17249 79183976
Alcohol interaction 15.30 9.99 7 543156 4867 79196358
Erectile dysfunction 15.29 9.99 50 543113 14614 79186611
Blood urea increased 15.21 9.99 237 542926 48553 79152672
Pulmonary hypertension 15.18 9.99 233 542930 47847 79153378
Schizophrenia 15.18 9.99 54 543109 15386 79185839
Salivary hypersecretion 15.18 9.99 48 543115 14176 79187049
Incoherent 15.16 9.99 18 543145 7674 79193551
COVID-19 15.12 9.99 899 542264 156775 79044450
Toothache 15.12 9.99 205 542958 19765 79181460
Lacrimal disorder 15.12 9.99 18 543145 491 79200734
Right ventricular failure 14.98 9.99 96 543067 23401 79177824
Strongyloidiasis 14.98 9.99 4 543159 3894 79197331
Lymph gland infection 14.98 9.99 19 543144 554 79200671
Injection site extravasation 14.96 9.99 115 543048 9554 79191671
Type 1 diabetes mellitus 14.96 9.99 15 543148 6904 79194321
Dactylitis 14.90 9.99 47 543116 2710 79198515
Personality disorder 14.87 9.99 12 543151 6134 79195091
Amylase increased 14.85 9.99 34 543129 11175 79190050
Device expulsion 14.83 9.99 109 543054 25752 79175473
Tuberculin test positive 14.81 9.99 54 543109 3354 79197871
Skin toxicity 14.80 9.99 21 543142 8293 79192932
Renal disorder 14.71 9.99 200 542963 41905 79159320
Aplasia 14.68 9.99 19 543144 7801 79193424
Polydipsia 14.65 9.99 14 543149 6591 79194634
Lower respiratory tract congestion 14.64 9.99 60 543103 3937 79197288
Foetal exposure during pregnancy 14.63 9.99 78 543085 5712 79195513
Hyperpyrexia 14.61 9.99 12 543151 6080 79195145
Bone density abnormal 14.60 9.99 50 543113 3010 79198215
Diabetes mellitus inadequate control 14.54 9.99 101 543062 24163 79177062
Hypomania 14.50 9.99 18 543145 7526 79193699
Acute lymphocytic leukaemia recurrent 14.50 9.99 7 543156 4717 79196508
Anal fissure 14.47 9.99 96 543067 7607 79193618
Drug screen positive 14.47 9.99 12 543151 6051 79195174
Coronary artery bypass 14.46 9.99 12 543151 6050 79195175
Bronchial secretion retention 14.35 9.99 5 543158 4099 79197126
Hypertriglyceridaemia 14.30 9.99 42 543121 12698 79188527
Haematuria 14.29 9.99 358 542805 68478 79132747
Osteoporotic fracture 14.25 9.99 62 543101 4178 79197047
Walking aid user 14.23 9.99 118 543045 10030 79191195
Wound infection pseudomonas 14.17 9.99 33 543130 1588 79199637
Prostatic specific antigen increased 14.17 9.99 31 543132 10355 79190870
Tooth infection 14.12 9.99 193 542970 18639 79182586
Ligament rupture 14.09 9.99 53 543110 3341 79197884
Lymphatic fistula 14.09 9.99 22 543141 781 79200444
Renal tubular disorder 14.09 9.99 14 543149 6472 79194753
Dyslipidaemia 14.06 9.99 37 543126 11596 79189629
Kidney infection 14.04 9.99 218 542945 21633 79179592
Tooth disorder 14.03 9.99 254 542909 25979 79175246
Lipase increased 14.01 9.99 61 543102 16405 79184820
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.01 9.99 4 543159 3725 79197500
Clear cell renal cell carcinoma 14.00 9.99 44 543119 2532 79198693
Acute graft versus host disease in intestine 14.00 9.99 5 543158 4036 79197189
Persecutory delusion 14.00 9.99 8 543155 4901 79196324
C-reactive protein decreased 13.98 9.99 45 543118 2623 79198602
Hypophosphataemia 13.94 9.99 79 543084 19834 79181391
Acute myeloid leukaemia recurrent 13.93 9.99 3 543160 3380 79197845
Joint lock 13.93 9.99 51 543112 3174 79198051
C-reactive protein 13.93 9.99 69 543094 4910 79196315
Pneumonia bacterial 13.91 9.99 76 543087 19255 79181970
Circulatory collapse 13.86 9.99 177 542986 37491 79163734
Intracranial pressure increased 13.86 9.99 22 543141 8300 79192925
Visual acuity reduced 13.83 9.99 131 543032 29338 79171887
Laryngospasm 13.75 9.99 5 543158 3992 79197233
Depression 13.75 9.99 1280 541883 215510 78985715
Anger 13.75 9.99 65 543098 17097 79184128
Bone marrow failure 13.75 9.99 255 542908 50852 79150373
Spinal osteoarthritis 13.75 9.99 176 542987 16751 79184474
Haemorrhage in pregnancy 13.72 9.99 30 543133 1384 79199841
Blood lactate dehydrogenase increased 13.71 9.99 186 542977 38984 79162241
Bradykinesia 13.65 9.99 21 543142 8022 79193203
Depressed mood 13.64 9.99 240 542923 48240 79152985
Kidney transplant rejection 13.63 9.99 31 543132 10215 79191010
Skin exfoliation 13.58 9.99 279 542884 54821 79146404
Alcohol abuse 13.57 9.99 10 543153 5353 79195872
Dry skin 13.49 9.99 356 542807 67639 79133586
Immunosuppression 13.48 9.99 140 543023 12663 79188562
Systemic inflammatory response syndrome 13.46 9.99 37 543126 11428 79189797
Capillary leak syndrome 13.35 9.99 5 543158 3920 79197305
Anticholinergic syndrome 13.33 9.99 4 543159 3607 79197618
Femoral hernia incarcerated 13.31 9.99 22 543141 820 79200405
Product administered to patient of inappropriate age 13.24 9.99 11 543152 5542 79195683
Cerebral haematoma 13.23 9.99 21 543142 7921 79193304
Intervertebral disc degeneration 13.19 9.99 165 542998 15620 79185605
Coronary arterial stent insertion 13.18 9.99 13 543150 6031 79195194
Chronic sinusitis 13.18 9.99 45 543118 12981 79188244
Hypertonia 13.14 9.99 18 543145 7214 79194011
Pain in jaw 13.13 9.99 228 542935 45923 79155302
Myopathy 13.12 9.99 84 543079 20479 79180746
Immunosuppressant drug level increased 13.11 9.99 26 543137 9001 79192224
Joint warmth 13.05 9.99 32 543131 1592 79199633
Drug abuser 13.04 9.99 13 543150 6000 79195225
Cervical incompetence 13.03 9.99 17 543146 510 79200715
Lip blister 13.01 9.99 45 543118 2722 79198503
Drug dose omission by device 13.00 9.99 14 543149 6236 79194989
Breast abscess 12.99 9.99 30 543133 1436 79199789
Panic attack 12.98 9.99 104 543059 24112 79177113
Psychomotor skills impaired 12.95 9.99 10 543153 5227 79195998
Oligoarthritis 12.93 9.99 20 543143 704 79200521
Brain injury 12.90 9.99 38 543125 11479 79189746
Road traffic accident 12.85 9.99 389 542774 43275 79157950
Blood folate increased 12.80 9.99 17 543146 519 79200706
Small for dates baby 12.78 9.99 16 543147 460 79200765
Type I hypersensitivity 12.78 9.99 7 543156 4391 79196834
Inhibitory drug interaction 12.66 9.99 62 543101 4391 79196834
Intestinal ischaemia 12.65 9.99 47 543116 13223 79188002
Aphthous ulcer 12.63 9.99 173 542990 16716 79184509
Human anti-human antibody test 12.63 9.99 15 543148 408 79200817
Metastasis 12.63 9.99 17 543146 6863 79194362
Peritoneal dialysis complication 12.60 9.99 40 543123 2314 79198911
Drug specific antibody 12.59 9.99 43 543120 2585 79198640
Cyst rupture 12.58 9.99 19 543144 655 79200570
Abortion threatened 12.57 9.99 15 543148 410 79200815
Joint ankylosis 12.56 9.99 38 543125 2142 79199083
Alanine aminotransferase increased 12.55 9.99 945 542218 161625 79039600
Dry eye 12.53 9.99 335 542828 36596 79164629
Neck pain 12.49 9.99 631 542532 74786 79126439
Complications of transplanted kidney 12.44 9.99 15 543148 6351 79194874
Angina unstable 12.43 9.99 64 543099 16463 79184762
Congestive cardiomyopathy 12.39 9.99 40 543123 11740 79189485
Sudden death 12.38 9.99 96 543067 22415 79178810
Human herpesvirus 6 infection 12.36 9.99 11 543152 5359 79195866
Renal tubular necrosis 12.31 9.99 110 543053 24929 79176296
Presyncope 12.27 9.99 201 542962 40853 79160372
Acute lung injury 12.26 9.99 3 543160 3097 79198128
Placental insufficiency 12.26 9.99 25 543138 1098 79200127
Vascular purpura 12.25 9.99 3 543160 3095 79198130
Threatened labour 12.23 9.99 18 543145 606 79200619
Palmoplantar keratoderma 12.20 9.99 5 543158 3711 79197514
Myofascial pain syndrome 12.20 9.99 36 543127 2001 79199224
Hepatitis C 12.20 9.99 41 543122 11884 79189341
Feeling abnormal 12.19 9.99 926 542237 158273 79042952
Generalised oedema 12.17 9.99 103 543060 23606 79177619
Arthropod bite 12.15 9.99 99 543064 8372 79192853
Nail injury 12.14 9.99 18 543145 610 79200615
Photophobia 12.14 9.99 202 542961 20326 79180899
Candida infection 12.13 9.99 185 542978 38029 79163196
Hypoventilation 12.13 9.99 19 543144 7205 79194020
Rash erythematous 12.11 9.99 300 542863 57469 79143756
Sleep disorder due to a general medical condition 12.08 9.99 53 543110 14224 79187001
Abortion incomplete 12.05 9.99 3 543160 3061 79198164
Bronchopulmonary aspergillosis allergic 12.03 9.99 3 543160 3058 79198167
Deep vein thrombosis 12.03 9.99 687 542476 120232 79080993
Gestational hypertension 12.02 9.99 34 543129 1845 79199380
Defaecation disorder 12.02 9.99 19 543144 682 79200543
Reversible cerebral vasoconstriction syndrome 12.01 9.99 3 543160 3054 79198171
Carotid artery thrombosis 11.99 9.99 3 543160 3050 79198175
Psychiatric decompensation 11.97 9.99 6 543157 3957 79197268
Diabetes mellitus 11.97 9.99 425 542738 77965 79123260
Ketoacidosis 11.95 9.99 22 543141 7832 79193393
Oesophageal fibrosis 11.93 9.99 10 543153 176 79201049
Respiratory tract infection viral 11.90 9.99 59 543104 4200 79197025
Pulmonary tuberculosis 11.87 9.99 93 543070 7772 79193453
Sinus congestion 11.85 9.99 196 542967 19700 79181525
Pulmonary pain 11.82 9.99 61 543102 4412 79196813
Pharyngitis 11.74 9.99 216 542947 22159 79179066
Long QT syndrome 11.67 9.99 14 543149 5941 79195284
Sensitisation 11.63 9.99 4 543159 3307 79197918
Pneumothorax 11.61 9.99 130 543033 28193 79173032
Cell death 11.59 9.99 9 543154 4690 79196535
Complication of device removal 11.58 9.99 6 543157 3883 79197342
Metastases to meninges 11.58 9.99 5 543158 3596 79197629
Deformity 11.56 9.99 108 543055 9497 79191728
Anal fistula 11.55 9.99 84 543079 6860 79194365
Frequent bowel movements 11.52 9.99 273 542890 29266 79171959
Adverse drug reaction 11.52 9.99 558 542605 65834 79135391
Iodine allergy 11.52 9.99 17 543146 574 79200651
Pulmonary function test abnormal 11.47 9.99 7 543156 4137 79197088
Spondylitis 11.46 9.99 63 543100 4668 79196557
Neutrophilia 11.46 9.99 23 543140 7928 79193297
Lethargy 11.46 9.99 445 542718 80847 79120378
Ischaemic cardiomyopathy 11.32 9.99 22 543141 7673 79193552
Benign ovarian tumour 11.28 9.99 13 543150 342 79200883
Hepatitis B 11.26 9.99 25 543138 8307 79192918
Accidental exposure to product by child 11.25 9.99 3 543160 2923 79198302
Inadequate analgesia 11.25 9.99 9 543154 4620 79196605
Pseudomembranous colitis 11.22 9.99 12 543151 5362 79195863
Epstein-Barr virus associated lymphoproliferative disorder 11.20 9.99 5 543158 3527 79197698
Spinal disorder 11.19 9.99 113 543050 10147 79191078
Nerve compression 11.18 9.99 104 543059 9135 79192090
Tooth fracture 11.17 9.99 124 543039 11406 79189819
Neurologic neglect syndrome 11.14 9.99 3 543160 2904 79198321
Troponin increased 11.12 9.99 81 543082 19174 79182051
Mass 11.11 9.99 174 542989 17298 79183927
Gastric cancer 11.11 9.99 34 543129 10145 79191080
Hypercholesterolaemia 11.11 9.99 220 542943 22875 79178350
Mycobacterium tuberculosis complex test positive 11.10 9.99 43 543120 2749 79198476
Atrial flutter 11.08 9.99 94 543069 21531 79179694
Steroid diabetes 11.06 9.99 5 543158 3501 79197724
Nephrotic syndrome 11.04 9.99 39 543124 11135 79190090
Colitis microscopic 11.03 9.99 37 543126 10731 79190494
Skin neoplasm excision 11.02 9.99 23 543140 1027 79200198
Arthritis bacterial 11 9.99 103 543060 9063 79192162
Extradural haematoma 10.96 9.99 3 543160 2873 79198352
Cartilage injury 10.95 9.99 29 543134 1514 79199711
Bone density increased 10.94 9.99 20 543143 809 79200416
Tooth abscess 10.91 9.99 163 543000 16047 79185178
Hernia 10.89 9.99 170 542993 16889 79184336
Eyelid oedema 10.87 9.99 52 543111 13635 79187590
Ventricular extrasystoles 10.85 9.99 84 543079 19620 79181605
Ventricular hypokinesia 10.85 9.99 30 543133 9249 79191976
Skin injury 10.84 9.99 49 543114 3357 79197868
Nephrolithiasis 10.80 9.99 455 542708 52836 79148389
Skin laceration 10.79 9.99 266 542897 28696 79172529
Skin ulcer haemorrhage 10.76 9.99 16 543147 544 79200681
Osteonecrosis 10.76 9.99 148 543015 30947 79170278
Bacterial sepsis 10.75 9.99 25 543138 8173 79193052
Vascular device infection 10.74 9.99 35 543128 10241 79190984
Cholestasis of pregnancy 10.71 9.99 22 543141 971 79200254
Muscle spasticity 10.71 9.99 94 543069 21381 79179844
Hepatitis E antibody positive 10.58 9.99 11 543152 257 79200968
Renal cancer 10.58 9.99 45 543118 12181 79189044
Neutropenic colitis 10.58 9.99 14 543149 5693 79195532
Euglycaemic diabetic ketoacidosis 10.56 9.99 19 543144 6825 79194400
Mitochondrial toxicity 10.54 9.99 4 543159 3110 79198115
Intestinal stenosis 10.48 9.99 52 543111 3702 79197523
Foetal death 10.47 9.99 92 543071 7952 79193273
Vacuum extractor delivery 10.44 9.99 8 543155 123 79201102
Cogwheel rigidity 10.39 9.99 4 543159 3084 79198141
Prescribed underdose 10.38 9.99 269 542894 29245 79171980
Uterine contractions during pregnancy 10.33 9.99 14 543149 436 79200789
Amyloid arthropathy 10.33 9.99 16 543147 564 79200661
Vascular rupture 10.30 9.99 30 543133 1655 79199570
Diplopia 10.29 9.99 163 543000 33303 79167922
Product monitoring error 10.26 9.99 29 543134 8877 79192348
Hyperhomocysteinaemia 10.26 9.99 15 543148 502 79200723
Onychomadesis 10.25 9.99 66 543097 5176 79196049
Hypotonia 10.16 9.99 49 543114 12821 79188404
Chest pain 10.15 9.99 1729 541434 280575 78920650
Eating disorder 10.14 9.99 91 543072 20606 79180619
Tumour haemorrhage 10.14 9.99 8 543155 4136 79197089
Labyrinthitis 10.14 9.99 43 543120 2865 79198360
Dyspnoea exertional 10.12 9.99 487 542676 86586 79114639
Tetany 10.11 9.99 3 543160 2725 79198500
Lip and/or oral cavity cancer 10.11 9.99 23 543140 1090 79200135
Precancerous skin lesion 10.08 9.99 26 543137 1335 79199890
Investigation abnormal 10.07 9.99 34 543129 2032 79199193
Autonomic nervous system imbalance 10.05 9.99 10 543153 4620 79196605
Retinal haemorrhage 10.04 9.99 26 543137 8191 79193034
Skin graft failure 10.03 9.99 10 543153 222 79201003
Abortion missed 10.02 9.99 25 543138 1258 79199967
Systemic candida 10.01 9.99 19 543144 6687 79194538

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA04 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC S01XA26 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
MeSH PA D003879 Dermatologic Agents
MeSH PA D018977 Micronutrients
MeSH PA D017319 Photosensitizing Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:47868 photosensitising agent
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77182 food coloring
CHEBI has role CHEBI:78675 fundamental metabolites
CHEBI has role CHEBI:84087 human urinary metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Glutaric aciduria, type 2 off-label use 22886006 DOID:0060358
Glutaric aciduria, type 1 off-label use 76175005
Migraine Prevention off-label use
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Obstruction of bile duct contraindication 30144000
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Agoraphobia contraindication 70691001 DOID:593
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Panic disorder contraindication 371631005 DOID:594
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.13 acidic
pKa2 11.89 acidic
pKa3 13.48 acidic
pKa4 2.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Flavin reductase (NADPH) Enzyme WOMBAT-PK
Riboflavin kinase Kinase WOMBAT-PK
Riboflavin-binding protein Unclassified Kd 8.30 CHEMBL

External reference:

IDSource
4017778 VUID
N0000146139 NUI
D00050 KEGG_DRUG
4017633 VANDF
4017778 VANDF
4021901 VANDF
CHEBI:57986 CHEBI
RBF PDB_CHEM_ID
CHEMBL1534 ChEMBL_ID
CHEMBL1397833 ChEMBL_ID
6578 IUPHAR_LIGAND_ID
DB00140 DRUGBANK_ID
9346 RXNORM
5060 MMSL
5062 MMSL
5422 MMSL
5683 MMSL
d00409 MMSL
001059 NDDF
13235001 SNOMEDCT_US
329260009 SNOMEDCT_US
D012256 MESH_DESCRIPTOR_UI
C0035527 UMLSCUI
419 INN_ID
493570 PUBCHEM_CID
TLM2976OFR UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 3 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3.40 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3.40 mg ORAL unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 3.40 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 3.40 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 3.40 mg ORAL Unapproved drug other 11 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1.80 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1.80 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.80 mg ORAL Unapproved drug other 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.80 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 5 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 5 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1.80 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 3.40 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 1.60 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections