riboflavin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2834 83-88-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • riboflavine
  • beflavine
  • lactoflavin
  • lactoflavine
  • Vitamin B2
  • riboflavin (vit B2)
  • riboflavin
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.
  • Molecular weight: 376.37
  • Formula: C17H20N4O6
  • CLOGP: -0.73
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 5
  • TPSA: 155.05
  • ALOGS: -2.76
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.11 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.33 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1657.57 9.95 2696 354033 101335 52891002
Rheumatoid arthritis 1654.10 9.95 5233 351496 309298 52683039
Systemic lupus erythematosus 1509.16 9.95 2873 353856 122541 52869796
Glossodynia 1292.88 9.95 2367 354362 97924 52894413
Hand deformity 1022.55 9.95 1946 354783 82903 52909434
Alopecia 904.01 9.95 3526 353203 231057 52761280
Maternal exposure during pregnancy 893.84 9.95 2674 354055 152965 52839372
Arthropathy 883.06 9.95 2504 354225 138949 52853388
Abdominal discomfort 861.61 9.95 3335 353394 217727 52774610
Wound 802.46 9.95 1843 354886 89714 52902623
Completed suicide 679.70 9.95 68 356661 138133 52854204
Infusion related reaction 666.95 9.95 2425 354304 153532 52838805
Synovitis 630.54 9.95 1866 354863 106027 52886310
Contraindicated product administered 627.10 9.95 2164 354565 133465 52858872
Pericarditis 589.13 9.95 1319 355410 63087 52929250
Anti-cyclic citrullinated peptide antibody positive 584.82 9.95 1225 355504 55947 52936390
Joint swelling 558.88 9.95 3064 353665 231574 52760763
Pain 554.47 9.95 6185 350544 582213 52410124
Discomfort 550.93 9.95 1644 355085 93828 52898509
Swelling 546.59 9.95 2627 354102 188478 52803859
Toxicity to various agents 464.37 9.95 470 356259 219128 52773209
Death 417.35 9.95 1127 355602 356105 52636232
Product use issue 394.55 9.95 1913 354816 137671 52854666
Rheumatoid factor positive 382.53 9.95 849 355880 40349 52951988
Arthralgia 371.14 9.95 4529 352200 435254 52557083
Drug abuse 325.28 9.95 31 356698 65495 52926842
Drug interaction 325.15 9.95 607 356122 218722 52773615
Duodenal ulcer perforation 309.83 9.95 710 356019 34473 52957864
Helicobacter infection 298.33 9.95 746 355983 38323 52954014
Intentional overdose 283.31 9.95 53 356676 67152 52925185
Exposure during pregnancy 278.40 9.95 1603 355126 123257 52869080
Hepatic enzyme increased 267.69 9.95 1599 355130 124596 52867741
Hip arthroplasty 262.93 9.95 578 356151 27284 52965053
Musculoskeletal stiffness 243.86 9.95 1535 355194 121833 52870504
Treatment failure 242.33 9.95 1579 355150 126824 52865513
Knee arthroplasty 239.71 9.95 625 356104 32944 52959393
Drug intolerance 225.90 9.95 2232 354497 203261 52789076
Overdose 211.47 9.95 245 356484 107491 52884846
Febrile neutropenia 209.92 9.95 235 356494 104701 52887636
Therapeutic product effect decreased 207.85 9.95 1496 355233 124159 52868178
Acute kidney injury 199.22 9.95 946 355783 252922 52739415
Suicide attempt 195.64 9.95 72 356657 58096 52934241
Nasopharyngitis 182.20 9.95 2027 354702 190268 52802069
Cardiac arrest 179.55 9.95 217 356512 93450 52898887
Red blood cell sedimentation rate abnormal 176.69 9.95 350 356379 15339 52976998
Drug ineffective 176.57 9.95 6899 349830 810346 52181991
C-reactive protein abnormal 167.91 9.95 465 356264 25405 52966932
Drug hypersensitivity 162.05 9.95 1073 355656 264169 52728168
Depressed level of consciousness 156.89 9.95 84 356645 54344 52937993
Malignant neoplasm progression 140.02 9.95 163 356566 71378 52920959
Pregnancy 136.67 9.95 492 356237 30949 52961388
Rheumatic fever 135.74 9.95 276 356453 12328 52980009
Psoriatic arthropathy 135.59 9.95 660 356069 47530 52944807
Disease progression 135.56 9.95 300 356429 101620 52890717
Device expulsion 133.41 9.95 20 356709 29793 52962544
Sickle cell anaemia with crisis 133.38 9.95 158 356571 4369 52987968
Cardiac failure 132.91 9.95 231 356498 85613 52906724
Swollen joint count increased 132.15 9.95 256 356473 11034 52981303
Lactic acidosis 130.62 9.95 43 356686 37210 52955127
Hyponatraemia 129.93 9.95 338 356391 108269 52884068
Hypersensitivity 129.16 9.95 2052 354677 208613 52783724
Diarrhoea 126.31 9.95 3203 353526 622343 52369994
Bradycardia 125.47 9.95 175 356554 70881 52921456
Nausea 121.36 9.95 3996 352733 752095 52240242
Constipation 120.41 9.95 804 355925 197608 52794729
Neutropenia 119.05 9.95 603 356126 158582 52833755
Dyspnoea 119.02 9.95 2999 353730 583233 52409104
Anxiety 114.45 9.95 807 355922 195897 52796440
Fatigue 110.36 9.95 5951 350778 724555 52267782
Injection site erythema 109.87 9.95 888 355841 76361 52915976
Tremor 109.70 9.95 450 356279 125286 52867051
Impaired healing 108.72 9.95 769 355960 63436 52928901
Asthenia 106.58 9.95 1636 355093 341954 52650383
Asthma 103.41 9.95 377 356352 108595 52883742
Respiratory arrest 100.78 9.95 49 356680 33491 52958846
Arthritis 100.03 9.95 957 355772 86341 52905996
Drug reaction with eosinophilia and systemic symptoms 99.97 9.95 47 356682 32753 52959584
Hypotension 99.41 9.95 1153 355576 252923 52739414
Vomiting 98.16 9.95 2553 354176 494586 52497751
Agitation 98.00 9.95 150 356579 58476 52933861
Electrocardiogram QT prolonged 97.50 9.95 141 356588 56262 52936075
Dizziness 95.58 9.95 1834 354895 370425 52621912
Renal failure 95.35 9.95 437 356292 118015 52874322
Sedation 94.40 9.95 40 356689 29635 52962702
Live birth 92.16 9.95 265 356464 14794 52977543
Somnolence 89.50 9.95 705 356024 167029 52825308
Rash 88.81 9.95 3737 352992 442454 52549883
Injection site pruritus 88.06 9.95 527 356202 41062 52951275
Condition aggravated 87.49 9.95 2603 354126 294531 52697806
Rhabdomyolysis 86.01 9.95 100 356629 43823 52948514
Osteoarthritis 85.91 9.95 783 355946 69703 52922634
Abortion spontaneous 85.73 9.95 570 356159 46065 52946272
Blood pressure fluctuation 84.63 9.95 464 356265 35006 52957331
Sopor 83.92 9.95 19 356710 21065 52971272
Cardio-respiratory arrest 82.24 9.95 168 356561 58590 52933747
Injection site pain 81.30 9.95 1135 355594 112256 52880081
Intentional self-injury 80.56 9.95 34 356695 25250 52967087
Product quality issue 78.37 9.95 79 356650 36944 52955393
Injection site swelling 74.76 9.95 515 356214 42113 52950224
Multiple sclerosis relapse 73.78 9.95 116 356613 44737 52947600
Injection site reaction 72.10 9.95 587 356142 50579 52941758
Hyperhidrosis 71.56 9.95 368 356361 96425 52895912
Insomnia 71.54 9.95 853 355876 186219 52806118
Drug dependence 71.48 9.95 27 356702 21445 52970892
Drug withdrawal syndrome 71.35 9.95 50 356679 27972 52964365
Joint effusion 70.44 9.95 223 356506 13129 52979208
Hypoglycaemia 70.28 9.95 184 356545 58829 52933508
Neuropathy peripheral 69.32 9.95 405 356324 102782 52889555
Basal cell carcinoma 69.31 9.95 326 356403 23143 52969194
Neoplasm progression 69.04 9.95 59 356670 29860 52962477
Lower respiratory tract infection 69.01 9.95 920 355809 90061 52902276
Tachycardia 67.85 9.95 434 356295 107778 52884559
Disability assessment scale score increased 67.02 9.95 82 356647 2347 52989990
Caesarean section 66.92 9.95 261 356468 17059 52975278
Sleep disorder due to general medical condition, insomnia type 65.99 9.95 330 356399 24019 52968318
Hyperglycaemia 63.74 9.95 106 356623 39978 52952359
Encephalopathy 63.63 9.95 92 356637 36716 52955621
Hepatic failure 63.38 9.95 88 356641 35718 52956619
Renal impairment 63.16 9.95 314 356415 83004 52909333
Myalgia 63.13 9.95 579 356150 132912 52859425
Hypoxia 63.01 9.95 178 356551 55502 52936835
Palmar-plantar erythrodysaesthesia syndrome 62.76 9.95 33 356696 21573 52970764
Serotonin syndrome 62.26 9.95 51 356678 26355 52965982
Hepatic function abnormal 62.05 9.95 94 356635 36805 52955532
Sinusitis 61.88 9.95 1520 355209 167044 52825293
Respiratory failure 61.55 9.95 406 356323 100106 52892231
Syncope 61.45 9.95 467 356262 111526 52880811
Cholestasis 61.00 9.95 61 356668 28634 52963703
Pulmonary arterial hypertension 60.76 9.95 55 356674 27067 52965270
Metabolic acidosis 60.63 9.95 119 356610 42123 52950214
Coma 60.41 9.95 211 356518 61572 52930765
No adverse event 59.54 9.95 107 356622 39158 52953179
Urticaria 59.34 9.95 601 356128 135284 52857053
Muscle injury 58.48 9.95 370 356359 29396 52962941
Joint laxity 58.30 9.95 75 356654 2261 52990076
Red blood cell sedimentation rate increased 57.78 9.95 353 356376 27704 52964633
Folliculitis 57.33 9.95 386 356343 31323 52961014
Grip strength decreased 57.26 9.95 191 356538 11558 52980779
Drug resistance 57.24 9.95 31 356698 19931 52972406
Blood pressure diastolic abnormal 56.55 9.95 157 356572 8588 52983749
Multiple organ dysfunction syndrome 55.89 9.95 188 356541 55489 52936848
Pulmonary embolism 55.14 9.95 494 356235 113948 52878389
Intentional product misuse 55.08 9.95 159 356570 49233 52943104
Plasma cell myeloma 54.95 9.95 152 356577 47722 52944615
Altered state of consciousness 54.88 9.95 51 356678 24785 52967552
Hepatocellular injury 54.79 9.95 72 356657 29914 52962423
Thrombocytopenia 54.78 9.95 628 356101 138099 52854238
Diabetic ketoacidosis 54.14 9.95 33 356696 19882 52972455
Cognitive disorder 53.79 9.95 139 356590 44639 52947698
Cardiac failure congestive 53.17 9.95 382 356347 92375 52899962
Foetal exposure during pregnancy 52.59 9.95 405 356324 34310 52958027
Hallucination 52.55 9.95 184 356545 53654 52938683
Contusion 52.54 9.95 1036 355693 109696 52882641
Blood glucose increased 52.29 9.95 303 356426 77058 52915279
Muscle spasticity 52.18 9.95 27 356702 17811 52974526
Anaemia 52.08 9.95 1430 355299 275288 52717049
Decreased appetite 51.77 9.95 1070 355659 213904 52778433
Hypokalaemia 51.29 9.95 406 356323 96111 52896226
Osteoporosis 51.07 9.95 505 356224 45955 52946382
Blood pressure systolic abnormal 51.03 9.95 133 356596 7006 52985331
Foot deformity 50.57 9.95 252 356477 18316 52974021
Premature labour 49.98 9.95 189 356540 12173 52980164
Blister 49.63 9.95 771 355958 77982 52914355
Disturbance in attention 48.37 9.95 98 356631 34285 52958052
Emotional distress 48.17 9.95 89 356640 32228 52960109
Respiratory disorder 48.12 9.95 97 356632 34000 52958337
Seizure 47.78 9.95 595 356134 128914 52863423
Restlessness 47.76 9.95 71 356658 28016 52964321
Loss of personal independence in daily activities 47.68 9.95 693 356036 69122 52923215
Rheumatoid nodule 47.65 9.95 181 356548 11683 52980654
Bone erosion 47.17 9.95 173 356556 10979 52981358
Neck deformity 47.06 9.95 63 356666 1976 52990361
Cytomegalovirus infection 46.98 9.95 37 356692 19502 52972835
Fibromyalgia 46.48 9.95 475 356254 43600 52948737
Delirium 46.46 9.95 133 356596 41296 52951041
Gestational diabetes 45.88 9.95 138 356591 7901 52984436
Depression 45.58 9.95 906 355823 182146 52810191
Hyperkalaemia 45.54 9.95 197 356532 54059 52938278
Disorientation 45.14 9.95 125 356604 39234 52953103
Poisoning 45.13 9.95 18 356711 13832 52978505
Peripheral swelling 44.94 9.95 1744 354985 204364 52787973
Metastases to bone 44.74 9.95 38 356691 19290 52973047
Confusional state 44.33 9.95 975 355754 193246 52799091
Muscle spasms 44.02 9.95 635 356094 134160 52858177
Juvenile idiopathic arthritis 43.97 9.95 95 356634 4429 52987908
Injection site bruising 43.74 9.95 414 356315 37232 52955105
Fluid retention 43.57 9.95 201 356528 54200 52938137
Mydriasis 43.52 9.95 11 356718 11315 52981022
Maternal drugs affecting foetus 43.47 9.95 107 356622 5439 52986898
Psoriasis 43.41 9.95 821 355908 86268 52906069
Injection site rash 43.04 9.95 222 356507 16357 52975980
Anaphylactic reaction 42.95 9.95 222 356507 58104 52934233
Osteonecrosis of jaw 42.81 9.95 113 356616 36033 52956304
Dehydration 42.70 9.95 831 355898 167579 52824758
Feeling abnormal 42.59 9.95 642 356087 134659 52857678
Hypothermia 42.49 9.95 17 356712 13039 52979298
Vision blurred 42.34 9.95 367 356362 85237 52907100
Blood cholesterol increased 42.33 9.95 541 356188 52448 52939889
Shock 41.83 9.95 56 356673 23083 52969254
Balance disorder 41.70 9.95 302 356427 72905 52919432
Neutrophil count decreased 41.37 9.95 178 356551 48920 52943417
Tuberculosis 41.29 9.95 165 356564 10906 52981431
Ejection fraction decreased 41.27 9.95 43 356686 19805 52972532
Respiratory depression 41.15 9.95 17 356712 12789 52979548
Weight increased 41.13 9.95 1716 355013 202851 52789486
Chest discomfort 41.04 9.95 447 356282 99248 52893089
Angioedema 40.93 9.95 144 356585 41932 52950405
Mental status changes 40.83 9.95 132 356597 39439 52952898
Pre-eclampsia 40.75 9.95 139 356590 8508 52983829
Infective pulmonary exacerbation of cystic fibrosis 40.68 9.95 12 356717 11144 52981193
Localised infection 40.64 9.95 312 356417 26404 52965933
Multiple fractures 40.45 9.95 116 356613 6465 52985872
Blood pressure systolic increased 40.45 9.95 386 356343 34791 52957546
Enthesopathy 40.25 9.95 115 356614 6396 52985941
Loss of consciousness 40.17 9.95 530 356199 113682 52878655
Oral herpes 39.60 9.95 260 356469 20919 52971418
Dyspnoea exertional 39.57 9.95 211 356518 54789 52937548
Speech disorder 39.53 9.95 132 356597 39049 52953288
Orthostatic hypotension 39.18 9.95 88 356641 29665 52962672
Product administration error 39.03 9.95 52 356677 21479 52970858
Extrapyramidal disorder 38.99 9.95 17 356712 12385 52979952
Gamma-glutamyltransferase increased 38.91 9.95 106 356623 33449 52958888
Blood creatine phosphokinase increased 38.77 9.95 85 356644 28900 52963437
Myocardial infarction 38.72 9.95 451 356278 98903 52893434
Type 2 diabetes mellitus 38.66 9.95 352 356377 31318 52961019
Acute hepatic failure 38.54 9.95 33 356696 16687 52975650
Ventricular septal defect 38.51 9.95 88 356641 4262 52988075
Cerebral haemorrhage 38.47 9.95 90 356639 29906 52962431
Abnormal behaviour 38.44 9.95 54 356675 21812 52970525
Limb deformity 38.33 9.95 82 356647 3797 52988540
Accidental overdose 37.80 9.95 53 356676 21426 52970911
Blood bilirubin increased 37.70 9.95 118 356611 35612 52956725
Disseminated intravascular coagulation 37.42 9.95 46 356683 19673 52972664
Deep vein thrombosis 36.89 9.95 365 356364 82548 52909789
Leukopenia 36.75 9.95 314 356415 73149 52919188
Blood alkaline phosphatase increased 36.69 9.95 147 356582 41215 52951122
Ascites 36.66 9.95 139 356590 39596 52952741
Sedation complication 36.61 9.95 3 356726 7163 52985174
Anaphylactic shock 36.59 9.95 56 356673 21837 52970500
Aspartate aminotransferase increased 36.52 9.95 372 356357 83657 52908680
Premature delivery 36.50 9.95 299 356430 25805 52966532
Nodule 36.34 9.95 220 356509 17209 52975128
Blood pressure diastolic decreased 36.25 9.95 214 356515 16589 52975748
Ill-defined disorder 36.25 9.95 497 356232 48947 52943390
Joint stiffness 36.17 9.95 335 356394 29948 52962389
Schizophrenia 35.79 9.95 12 356717 10267 52982070
White blood cell count decreased 35.37 9.95 602 356127 123873 52868464
Metastases to liver 34.96 9.95 56 356673 21440 52970897
Tenderness 34.96 9.95 239 356490 19491 52972846
Suicidal ideation 34.77 9.95 249 356480 60262 52932075
Posterior reversible encephalopathy syndrome 34.75 9.95 34 356695 16126 52976211
Herpes zoster 34.58 9.95 691 356038 73328 52919009
Product use in unapproved indication 34.58 9.95 535 356194 111754 52880583
Irritable bowel syndrome 34.23 9.95 444 356285 43188 52949149
Heart rate decreased 33.77 9.95 387 356342 36560 52955777
Drug level increased 33.40 9.95 53 356676 20368 52971969
Inflammation 33.22 9.95 552 356177 56584 52935753
Polyarthritis 33.09 9.95 121 356608 7668 52984669
Musculoskeletal pain 32.82 9.95 695 356034 74505 52917832
Alanine aminotransferase increased 32.81 9.95 443 356286 94652 52897685
Platelet count decreased 32.63 9.95 517 356212 107582 52884755
Blood pressure decreased 32.51 9.95 261 356468 61608 52930729
Arrhythmia 32.44 9.95 131 356598 36648 52955689
Joint destruction 32.33 9.95 72 356657 3427 52988910
Brain oedema 32.19 9.95 26 356703 13532 52978805
Vertigo 32.11 9.95 231 356498 55850 52936487
Unresponsive to stimuli 32.11 9.95 115 356614 33311 52959026
Ventricular tachycardia 32.09 9.95 43 356686 17719 52974618
Toxic skin eruption 31.44 9.95 25 356704 13114 52979223
Psychotic disorder 31.40 9.95 73 356656 24312 52968025
Dysarthria 31.25 9.95 152 356577 40416 52951921
Smear cervix abnormal 31.18 9.95 62 356667 2724 52989613
Small for dates baby 31.13 9.95 74 356655 3678 52988659
Femur fracture 31.13 9.95 403 356326 39182 52953155
Pyrexia 31.01 9.95 2299 354430 400894 52591443
Pain in jaw 30.96 9.95 153 356576 40516 52951821
Maternal exposure before pregnancy 30.94 9.95 96 356633 5590 52986747
Memory impairment 30.65 9.95 391 356338 84366 52907971
Blood pressure diastolic increased 30.54 9.95 111 356618 7013 52985324
Pain in extremity 30.50 9.95 2256 354473 282794 52709543
Therapeutic response decreased 30.45 9.95 467 356262 47102 52945235
Inappropriate antidiuretic hormone secretion 30.40 9.95 33 356696 14918 52977419
Premature rupture of membranes 30.29 9.95 87 356642 4853 52987484
Disability 30.15 9.95 164 356565 12334 52980003
Infection 30.07 9.95 1424 355305 170781 52821556
Nightmare 30.06 9.95 45 356684 17706 52974631
Eosinophilia 29.85 9.95 61 356668 21274 52971063
Dyskinesia 29.60 9.95 111 356618 31722 52960615
Torsade de pointes 29.57 9.95 26 356703 12979 52979358
Dysphagia 29.54 9.95 392 356337 84005 52908332
Ventricular fibrillation 29.41 9.95 22 356707 11903 52980434
Palpitations 29.40 9.95 494 356235 101854 52890483
Cytokine release syndrome 29.17 9.95 9 356720 8120 52984217
Agranulocytosis 29.08 9.95 73 356656 23676 52968661
Haemorrhage 28.94 9.95 248 356481 57739 52934598
Respiratory distress 28.89 9.95 122 356607 33705 52958632
Joint range of motion decreased 28.61 9.95 212 356517 17744 52974593
Atrial fibrillation 28.56 9.95 550 356179 111102 52881235
Latent tuberculosis 28.52 9.95 52 356677 2139 52990198
Intentional product use issue 28.48 9.95 660 356069 71834 52920503
Arthritis infective 28.30 9.95 96 356633 5859 52986478
Malignant melanoma 28.29 9.95 145 356584 10657 52981680
Pleural effusion 27.96 9.95 420 356309 88159 52904178
Tenosynovitis stenosans 27.83 9.95 53 356676 2255 52990082
Device dislocation 27.77 9.95 74 356655 23523 52968814
Chest pain 27.72 9.95 1016 355713 189169 52803168
Bone pain 27.57 9.95 212 356517 50510 52941827
Diabetes mellitus inadequate control 27.56 9.95 33 356696 14277 52978060
Developmental hip dysplasia 27.55 9.95 39 356690 1291 52991046
Wheezing 27.53 9.95 291 356438 64984 52927353
Dysgeusia 27.50 9.95 171 356558 42760 52949577
Injection site warmth 27.37 9.95 175 356554 13953 52978384
Jaundice 27.35 9.95 107 356622 30206 52962131
Skin ulcer 27.27 9.95 365 356364 35754 52956583
Cerebrovascular accident 27.24 9.95 517 356212 104657 52887680
Impaired quality of life 27.21 9.95 83 356646 4788 52987549
International normalised ratio increased 27.21 9.95 197 356532 47564 52944773
Creatinine renal clearance decreased 27.12 9.95 19 356710 10632 52981705
Synovial cyst 27.00 9.95 120 356609 8316 52984021
Acute generalised exanthematous pustulosis 26.63 9.95 18 356711 10263 52982074
Akathisia 26.55 9.95 12 356717 8559 52983778
Tenosynovitis 26.43 9.95 134 356595 9805 52982532
Pulmonary fibrosis 26.35 9.95 262 356467 23873 52968464
Oropharyngeal pain 26.33 9.95 721 356008 80547 52911790
Hospitalisation 26.27 9.95 326 356403 70686 52921651
Coagulopathy 26.15 9.95 58 356671 19640 52972697
Hypomagnesaemia 26.13 9.95 82 356647 24729 52967608
Placental disorder 26.13 9.95 41 356688 1490 52990847
Chronic kidney disease 26.13 9.95 176 356553 43194 52949143
Obstructive airways disorder 25.97 9.95 48 356681 17381 52974956
Skin papilloma 25.96 9.95 77 356652 4374 52987963
Neck mass 25.88 9.95 66 356663 3430 52988907
Pulmonary oedema 25.82 9.95 232 356497 53491 52938846
Face oedema 25.74 9.95 61 356668 20179 52972158
Aggression 25.61 9.95 76 356653 23327 52969010
Ischaemic stroke 25.55 9.95 51 356678 17942 52974395
Blood creatinine increased 25.39 9.95 394 356335 82268 52910069
Bronchospasm 25.37 9.95 45 356684 16553 52975784
Atrioventricular block complete 25.18 9.95 11 356718 8004 52984333
Wrong technique in product usage process 25.17 9.95 268 356461 59764 52932573
Bradyphrenia 25.09 9.95 7 356722 6743 52985594
Wheelchair user 24.90 9.95 80 356649 4746 52987591
Acute respiratory failure 24.72 9.95 116 356613 31142 52961195
Withdrawal syndrome 24.68 9.95 58 356671 19243 52973094
Multiple sclerosis 24.40 9.95 96 356633 27057 52965280
Pancreatitis acute 24.30 9.95 91 356638 26018 52966319
Asphyxia 24.13 9.95 5 356724 5896 52986441
Febrile bone marrow aplasia 23.99 9.95 9 356720 7180 52985157
Neuroleptic malignant syndrome 23.98 9.95 27 356702 12006 52980331
Polyneuropathy 23.94 9.95 32 356697 13201 52979136
Breast cancer metastatic 23.93 9.95 41 356688 15287 52977050
Synovial fluid analysis 23.90 9.95 42 356687 1678 52990659
Fear 23.77 9.95 47 356682 16594 52975743
Melaena 23.69 9.95 107 356622 29022 52963315
Rotator cuff repair 23.62 9.95 43 356686 1767 52990570
Pulmonary hypertension 23.59 9.95 149 356580 37121 52955216
Oedema peripheral 23.42 9.95 919 355810 169868 52822469
Atrial septal defect 23.39 9.95 100 356629 6814 52985523
C-reactive protein increased 23.35 9.95 607 356122 67279 52925058
Thrombotic microangiopathy 23.32 9.95 17 356712 9320 52983017
Loose body in joint 23.25 9.95 34 356695 1160 52991177
Acute myeloid leukaemia 23.19 9.95 49 356680 16883 52975454
Spinal stenosis 23.18 9.95 169 356560 14072 52978265
Laryngitis 23.18 9.95 136 356593 10519 52981818
Metastases to central nervous system 23.01 9.95 28 356701 12029 52980308
Flushing 22.89 9.95 333 356396 70267 52922070
Immune reconstitution inflammatory syndrome 22.82 9.95 7 356722 6339 52985998
Dysmorphism 22.73 9.95 48 356681 2202 52990135
Postoperative wound infection 22.63 9.95 122 356607 9144 52983193
Hypomania 22.48 9.95 3 356726 4879 52987458
Crying 22.45 9.95 75 356654 22187 52970150
Skin cancer 22.45 9.95 126 356603 9588 52982749
Transplant rejection 22.24 9.95 21 356708 10130 52982207
Stress cardiomyopathy 22.16 9.95 15 356714 8547 52983790
Drug ineffective for unapproved indication 22.16 9.95 68 356661 20652 52971685
Irritability 22.12 9.95 119 356610 30834 52961503
Mania 22.02 9.95 28 356701 11801 52980536
Graft versus host disease 22.02 9.95 10 356719 7112 52985225
Gastrointestinal haemorrhage 22.01 9.95 391 356338 79939 52912398
Polyhydramnios 21.94 9.95 47 356682 2178 52990159
Product adhesion issue 21.78 9.95 5 356724 5492 52986845
Parkinsonism 21.76 9.95 17 356712 8996 52983341
Body tinea 21.67 9.95 33 356696 1168 52991169
Fluid overload 21.59 9.95 104 356625 27727 52964610
Drug tolerance decreased 21.57 9.95 102 356627 7256 52985081
Body height below normal 21.49 9.95 43 356686 1898 52990439
Rash maculo-papular 21.47 9.95 114 356615 29635 52962702
Neurotoxicity 21.37 9.95 44 356685 15305 52977032
Blood calcium decreased 21.14 9.95 65 356664 19729 52972608
Tardive dyskinesia 21.08 9.95 14 356715 8056 52984281
Paralysis 21.05 9.95 19 356710 9365 52982972
Cellulitis 21.02 9.95 661 356068 75328 52917009
Device difficult to use 20.91 9.95 23 356706 10336 52982001
Cardiac failure acute 20.89 9.95 18 356711 9074 52983263
Joint injury 20.88 9.95 233 356496 21867 52970470
Acute chest syndrome 20.88 9.95 24 356705 642 52991695
Psychomotor hyperactivity 20.85 9.95 22 356707 10074 52982263
Cushingoid 20.65 9.95 99 356630 7083 52985254
Dactylitis 20.63 9.95 41 356688 1801 52990536
Sepsis 20.49 9.95 786 355943 145643 52846694
Glycosylated haemoglobin increased 20.27 9.95 29 356700 11626 52980711
Haematotoxicity 20.22 9.95 14 356715 7883 52984454
Substance abuse 20.14 9.95 3 356726 4491 52987846
Tumour lysis syndrome 20.11 9.95 14 356715 7860 52984477
Pulmonary tuberculosis 20.04 9.95 75 356654 4806 52987531
Influenza 20.03 9.95 804 355925 94575 52897762
Pemphigoid 20.00 9.95 9 356720 6435 52985902
Miosis 19.89 9.95 11 356718 6991 52985346
Clear cell renal cell carcinoma 19.89 9.95 31 356698 1120 52991217
Erythema multiforme 19.79 9.95 24 356705 10325 52982012
Ketoacidosis 19.73 9.95 3 356726 4423 52987914
Cardiogenic shock 19.69 9.95 56 356673 17426 52974911
Gastroenteritis viral 19.69 9.95 207 356522 19138 52973199
Antinuclear antibody positive 19.55 9.95 93 356636 6632 52985705
Abdominal distension 19.51 9.95 396 356333 79394 52912943
Body temperature decreased 19.38 9.95 183 356546 16444 52975893
Fracture 19.38 9.95 195 356534 17824 52974513
Scleritis 19.37 9.95 58 356671 3312 52989025
Cerebral infarction 19.16 9.95 91 356638 24353 52967984
Second primary malignancy 19.13 9.95 12 356717 7120 52985217
Acute graft versus host disease 19.08 9.95 3 356726 4314 52988023
Abdominal pain 19.02 9.95 1463 355266 254440 52737897
Urinary retention 18.96 9.95 112 356617 28354 52963983
Foetal death 18.86 9.95 117 356612 9230 52983107
Complication associated with device 18.79 9.95 51 356678 16114 52976223
Surgery 18.65 9.95 309 356420 31655 52960682
Hemiparesis 18.62 9.95 77 356652 21398 52970939
Tachypnoea 18.44 9.95 50 356679 15804 52976533
Stevens-Johnson syndrome 18.41 9.95 93 356636 24489 52967848
Unevaluable event 18.39 9.95 227 356502 49271 52943066
Poor venous access 18.37 9.95 122 356607 9853 52982484
Congenital arterial malformation 18.36 9.95 17 356712 350 52991987
Status epilepticus 18.34 9.95 47 356682 15137 52977200
Sinus tachycardia 18.34 9.95 88 356641 23484 52968853
Injection site haematoma 18.33 9.95 87 356642 6198 52986139
Back pain 18.23 9.95 1334 355395 232913 52759424
Breast feeding 18.20 9.95 26 356703 868 52991469
Anhedonia 18.18 9.95 27 356702 10660 52981677
Synovial disorder 18.18 9.95 26 356703 869 52991468
Pancreatitis 18.14 9.95 209 356520 45933 52946404
Myoclonus 18.12 9.95 50 356679 15714 52976623
Accidental exposure to product 18.06 9.95 89 356640 23585 52968752
Red blood cell sedimentation rate 18.03 9.95 52 356677 2907 52989430
Depressed mood 18.03 9.95 159 356570 36805 52955532
Joint noise 18.03 9.95 59 356670 3535 52988802
Shock haemorrhagic 17.87 9.95 21 356708 9162 52983175
Oedema 17.87 9.95 370 356359 73976 52918361
Atrioventricular block 17.83 9.95 13 356716 7127 52985210
Squamous cell carcinoma 17.82 9.95 104 356625 8028 52984309
Complication of device insertion 17.76 9.95 9 356720 6008 52986329
Muscular weakness 17.66 9.95 527 356202 100465 52891872
Metastases to lung 17.65 9.95 32 356697 11672 52980665
Lethargy 17.62 9.95 253 356476 53507 52938830
Dystonia 17.57 9.95 38 356691 12983 52979354
Fear of injection 17.51 9.95 79 356650 5510 52986827
Hypertransaminasaemia 17.28 9.95 3 356726 4013 52988324
Gestational hypertension 17.23 9.95 44 356685 2289 52990048
Panic attack 17.22 9.95 79 356650 21339 52970998
Dementia 17.19 9.95 56 356673 16694 52975643
Haemorrhage intracranial 17.17 9.95 40 356689 13312 52979025
Hallucination, auditory 17.04 9.95 33 356696 11740 52980597
Pharyngitis streptococcal 16.83 9.95 111 356618 8944 52983393
Bone marrow failure 16.77 9.95 125 356604 29990 52962347
Human antichimeric antibody positive 16.75 9.95 33 356696 1440 52990897
Haemophagocytic lymphohistiocytosis 16.63 9.95 22 356707 9115 52983222
Immunodeficiency 16.59 9.95 163 356566 14804 52977533
Device use error 16.57 9.95 8 356721 5491 52986846
Blood iron increased 16.55 9.95 32 356697 1377 52990960
Haemorrhage in pregnancy 16.52 9.95 37 356692 1768 52990569
Foetal anticonvulsant syndrome 16.51 9.95 19 356710 509 52991828
Subdural haematoma 16.49 9.95 43 356686 13770 52978567
Nervousness 16.46 9.95 126 356603 30052 52962285
Impaired work ability 16.39 9.95 155 356574 13935 52978402
Immunosuppression 16.34 9.95 99 356630 7745 52984592
Haematoma 16.33 9.95 146 356583 33698 52958639
Pathogen resistance 16.31 9.95 12 356717 6548 52985789
Antibody test positive 16.28 9.95 43 356686 2283 52990054
Fracture delayed union 16.20 9.95 43 356686 2290 52990047
Mouth ulceration 16.20 9.95 281 356448 29045 52963292
Maternal exposure during breast feeding 16.17 9.95 55 356674 3362 52988975
Leukocytosis 16.11 9.95 98 356631 24636 52967701
Foot fracture 16.04 9.95 213 356516 20826 52971511
Dislocation of vertebra 15.96 9.95 47 356682 2659 52989678
Aspergillus infection 15.86 9.95 16 356713 7480 52984857
Myocarditis 15.81 9.95 20 356709 8448 52983889
Cytopenia 15.77 9.95 23 356706 9147 52983190
Salivary hypersecretion 15.64 9.95 14 356715 6929 52985408
Bronchopulmonary aspergillosis 15.63 9.95 21 356708 8644 52983693
Acidosis 15.57 9.95 33 356696 11359 52980978
Neonatal respiratory distress syndrome 15.54 9.95 49 356680 2878 52989459
Diabetes mellitus 15.52 9.95 260 356469 53639 52938698
Drug-induced liver injury 15.50 9.95 123 356606 29110 52963227
Injection site haemorrhage 15.49 9.95 220 356509 21831 52970506
Joint dislocation 15.47 9.95 138 356591 12207 52980130
Hallucination, visual 15.42 9.95 69 356660 18763 52973574
Lupus-like syndrome 15.39 9.95 110 356619 9102 52983235
Labelled drug-drug interaction medication error 15.38 9.95 31 356698 10868 52981469
Hepatic cytolysis 15.38 9.95 18 356711 7867 52984470
Exomphalos 15.36 9.95 19 356710 550 52991787
Affective disorder 15.31 9.95 9 356720 5530 52986807
Infusion site erythema 15.29 9.95 22 356707 8800 52983537
Disease recurrence 15.26 9.95 80 356649 20866 52971471
Blood potassium decreased 15.24 9.95 185 356544 40275 52952062
Respiration abnormal 15.20 9.95 9 356720 5509 52986828
Aphasia 15.19 9.95 132 356597 30646 52961691
Catheter site pain 15.15 9.95 4 356725 3997 52988340
Talipes 15.13 9.95 32 356697 1470 52990867
Bone density decreased 15.08 9.95 126 356603 10938 52981399
Tubulointerstitial nephritis 15.05 9.95 58 356671 16446 52975891
Renal injury 15.00 9.95 27 356702 9877 52982460
Cardiomyopathy 14.98 9.95 61 356668 17027 52975310
Genital haemorrhage 14.94 9.95 15 356714 7029 52985308
Proteinuria 14.92 9.95 66 356663 18002 52974335
Incorrect route of product administration 14.88 9.95 72 356657 19172 52973165
Haemoptysis 14.86 9.95 118 356611 27921 52964416
Occult blood 14.79 9.95 28 356701 1186 52991151
Serum ferritin increased 14.79 9.95 75 356654 5489 52986848
Induced labour 14.79 9.95 25 356704 968 52991369
Infusion site pain 14.78 9.95 36 356693 11797 52980540
Cholecystitis chronic 14.77 9.95 30 356699 10488 52981849
Angina pectoris 14.71 9.95 122 356607 28603 52963734
Maternal exposure timing unspecified 14.70 9.95 50 356679 3056 52989281
Lip swelling 14.63 9.95 114 356615 27087 52965250
Injection site irritation 14.60 9.95 64 356665 4408 52987929
Mood altered 14.60 9.95 46 356683 13855 52978482
Hypophagia 14.55 9.95 135 356594 30927 52961410
Acute myocardial infarction 14.49 9.95 147 356582 33088 52959249
Bronchitis 14.48 9.95 900 355829 110999 52881338
Device related infection 14.47 9.95 91 356638 22695 52969642
Bone disorder 14.39 9.95 206 356523 20477 52971860
Injection site urticaria 14.32 9.95 138 356591 12469 52979868
Stillbirth 14.30 9.95 86 356643 6711 52985626
Autism spectrum disorder 14.26 9.95 21 356708 721 52991616
Ulcer 14.20 9.95 205 356524 20414 52971923
Bone density abnormal 14.18 9.95 50 356679 3112 52989225
Oliguria 14.16 9.95 25 356704 9213 52983124
Joint lock 14.14 9.95 39 356690 2125 52990212
Coronary artery disease 14.12 9.95 149 356580 33288 52959049
Clostridium difficile colitis 14.12 9.95 76 356653 19689 52972648
Colitis microscopic 14.05 9.95 16 356713 7078 52985259
Cyst 14.02 9.95 140 356589 12771 52979566
Vascular device infection 13.99 9.95 6 356723 4415 52987922
Lymphocyte count decreased 13.98 9.95 120 356609 27932 52964405
Toxic epidermal necrolysis 13.97 9.95 96 356633 23454 52968883
Multiple allergies 13.94 9.95 22 356707 8473 52983864
Acute pulmonary oedema 13.91 9.95 21 356708 8234 52984103
Anuria 13.90 9.95 40 356689 12400 52979937
Delusion 13.87 9.95 38 356691 11971 52980366
Wound infection 13.83 9.95 137 356592 12470 52979867
Bundle branch block left 13.69 9.95 16 356713 6997 52985340
Cholestasis of pregnancy 13.65 9.95 27 356702 1182 52991155
Tendon disorder 13.63 9.95 74 356655 5561 52986776
Hereditary angioedema 13.63 9.95 13 356716 6240 52986097
Headache 13.61 9.95 3283 353446 533538 52458799
Arthritis bacterial 13.56 9.95 78 356651 5990 52986347
Cervical incompetence 13.53 9.95 19 356710 624 52991713
Foetal distress syndrome 13.51 9.95 29 356700 1346 52990991
Dry skin 13.42 9.95 220 356509 45540 52946797
Pulmonary congestion 13.35 9.95 59 356670 16097 52976240
Hypophosphataemia 13.34 9.95 24 356705 8781 52983556
Dermatitis exfoliative 13.34 9.95 12 356717 5924 52986413
Myopathy 13.31 9.95 28 356701 9664 52982673
Abdominal pain upper 13.25 9.95 945 355784 165346 52826991
Paradoxical drug reaction 13.23 9.95 3 356726 3322 52989015
Mental disorder 13.19 9.95 102 356627 24274 52968063
Visual acuity reduced 13.17 9.95 92 356637 22393 52969944
Hepatotoxicity 13.13 9.95 121 356608 27759 52964578
Infection susceptibility increased 13.04 9.95 42 356687 2495 52989842
Sickle cell anaemia 13.03 9.95 18 356711 582 52991755
Eosinophil count increased 13.01 9.95 28 356701 9584 52982753
Epilepsy 12.94 9.95 110 356619 25657 52966680
Temperature regulation disorder 12.86 9.95 6 356723 4201 52988136
Limb malformation 12.85 9.95 17 356712 527 52991810
Pseudomonas infection 12.81 9.95 32 356697 10396 52981941
Aspiration 12.80 9.95 31 356698 10179 52982158
Catheter site erythema 12.73 9.95 6 356723 4176 52988161
Abnormal dreams 12.66 9.95 33 356696 10568 52981769
Ingrown hair 12.65 9.95 16 356713 474 52991863
Knee operation 12.59 9.95 68 356661 5100 52987237
Klebsiella infection 12.56 9.95 21 356708 7905 52984432
Generalised oedema 12.56 9.95 55 356674 15044 52977293
Device breakage 12.54 9.95 33 356696 10534 52981803
Joint warmth 12.52 9.95 29 356700 1417 52990920
Polyuria 12.50 9.95 21 356708 7890 52984447
Myofascial pain syndrome 12.40 9.95 37 356692 2109 52990228
Placental insufficiency 12.36 9.95 28 356701 1348 52990989
Hallucinations, mixed 12.30 9.95 7 356722 4379 52987958
Rheumatoid lung 12.30 9.95 39 356690 2298 52990039
Hypocalcaemia 12.28 9.95 131 356598 29206 52963131
Tongue disorder 12.28 9.95 102 356627 8839 52983498
Macular degeneration 12.22 9.95 42 356687 12319 52980018
Anterior chamber cleavage syndrome 12.18 9.95 10 356719 174 52992163
Sleep apnoea syndrome 12.18 9.95 113 356616 25889 52966448
Bradykinesia 12.13 9.95 7 356722 4346 52987991
Tooth infection 12.05 9.95 148 356581 14215 52978122
Endodontic procedure 12.02 9.95 43 356686 2696 52989641
Muscle rigidity 12.01 9.95 35 356694 10806 52981531
Nail injury 12 9.95 15 356714 439 52991898
Carpal tunnel syndrome 11.98 9.95 176 356553 17591 52974746
Malaise 11.95 9.95 2157 354572 355460 52636877
Crystal nephropathy 11.93 9.95 21 356708 840 52991497
Right ventricular failure 11.90 9.95 65 356664 16778 52975559
Cyanosis 11.87 9.95 64 356665 16575 52975762
Circulatory collapse 11.85 9.95 96 356633 22618 52969719
Hypertelorism 11.82 9.95 14 356715 387 52991950
Forceps delivery 11.77 9.95 10 356719 183 52992154
Tendonitis 11.68 9.95 169 356560 16837 52975500
Human anti-human antibody test 11.66 9.95 13 356716 336 52992001
Rash erythematous 11.66 9.95 179 356550 37444 52954893
Potentiating drug interaction 11.63 9.95 7 356722 4246 52988091
Dysuria 11.56 9.95 139 356590 30314 52962023
Tumour marker increased 11.54 9.95 6 356723 3947 52988390
Post procedural infection 11.53 9.95 93 356636 7988 52984349
Lymphadenectomy 11.49 9.95 22 356707 940 52991397
Blood count abnormal 11.47 9.95 84 356645 20231 52972106
Inflammatory pain 11.44 9.95 19 356710 725 52991612
Infusion site swelling 11.42 9.95 18 356711 6936 52985401
Skin exfoliation 11.41 9.95 171 356558 35912 52956425
Product physical issue 11.40 9.95 11 356718 5251 52987086
Swollen tongue 11.37 9.95 143 356586 30937 52961400
Hyperuricaemia 11.37 9.95 11 356718 5245 52987092
Amylase increased 11.36 9.95 14 356715 5980 52986357
Pericardial effusion 11.34 9.95 122 356607 27156 52965181
Vascular rupture 11.32 9.95 27 356702 1345 52990992
Pleuritic pain 11.32 9.95 82 356647 6814 52985523
Lymphatic fistula 11.30 9.95 21 356708 877 52991460
Patent ductus arteriosus 11.29 9.95 56 356673 4062 52988275
Renal mass 11.29 9.95 34 356695 1948 52990389
Muscle twitching 11.27 9.95 64 356665 16362 52975975
Incorrect product administration duration 11.27 9.95 35 356694 10589 52981748
COVID-19 11.26 9.95 176 356553 36712 52955625
Vacuum extractor delivery 11.19 9.95 9 356720 152 52992185
Blood glucose decreased 11.19 9.95 83 356646 19933 52972404
Wound infection pseudomonas 11.18 9.95 28 356701 1439 52990898
Renal tubular necrosis 11.16 9.95 39 356690 11380 52980957
Speech disorder developmental 11.14 9.95 16 356713 537 52991800
Transplant dysfunction 11.08 9.95 10 356719 4928 52987409
Hepatitis cholestatic 11.07 9.95 19 356710 7080 52985257
Bone lesion 11.07 9.95 13 356716 5673 52986664
Femoral hernia incarcerated 11.07 9.95 21 356708 891 52991446
Toxic encephalopathy 11.07 9.95 14 356715 5913 52986424
Cystitis 11.03 9.95 401 356328 46587 52945750
Trigeminal neuralgia 11.02 9.95 4 356725 3257 52989080
Anger 11.01 9.95 44 356685 12346 52979991
Abortion missed 11.00 9.95 31 356698 1710 52990627
Congenital hydronephrosis 10.99 9.95 14 356715 418 52991919
Abortion threatened 10.97 9.95 17 356712 611 52991726
Pancytopenia 10.97 9.95 727 356002 90201 52902136
Retrognathia 10.96 9.95 14 356715 419 52991918
Somnambulism 10.90 9.95 12 356717 5390 52986947
Blood loss anaemia 10.89 9.95 27 356702 8796 52983541
Ear infection 10.85 9.95 238 356491 25662 52966675
Bursitis 10.84 9.95 211 356518 22281 52970056
Injection site extravasation 10.83 9.95 87 356642 7465 52984872
Product prescribing error 10.83 9.95 100 356629 22931 52969406
Lymphoedema 10.81 9.95 31 356698 9622 52982715
Uterine contractions during pregnancy 10.81 9.95 16 356713 552 52991785
Product substitution issue 10.79 9.95 62 356667 15804 52976533
Inadequate analgesia 10.77 9.95 3 356726 2892 52989445
Dry eye 10.75 9.95 298 356431 33346 52958991
Ileus paralytic 10.75 9.95 9 356720 4602 52987735
Lung adenocarcinoma 10.74 9.95 60 356669 4558 52987779
Pulseless electrical activity 10.69 9.95 21 356708 7433 52984904
Cardiac disorder 10.63 9.95 236 356493 46730 52945607
Stress at work 10.62 9.95 23 356706 1074 52991263
Product complaint 10.59 9.95 44 356685 12213 52980124
Catatonia 10.56 9.95 7 356722 4033 52988304
Uterine perforation 10.56 9.95 21 356708 7398 52984939
Epstein-Barr virus infection 10.55 9.95 21 356708 7397 52984940
Coronary arterial stent insertion 10.53 9.95 3 356726 2851 52989486
Paranoia 10.51 9.95 40 356689 11384 52980953
Hepatitis C 10.51 9.95 17 356712 6484 52985853
Visual impairment 10.50 9.95 390 356339 72522 52919815
Ankyloglossia congenital 10.48 9.95 10 356719 214 52992123
Therapy change 10.48 9.95 13 356716 5539 52986798
Cartilage injury 10.46 9.95 30 356699 1672 52990665
Normal newborn 10.45 9.95 83 356646 7096 52985241
Drug abuser 10.44 9.95 4 356725 3149 52989188
Large for dates baby 10.43 9.95 15 356714 504 52991833
Pulmonary haemorrhage 10.41 9.95 19 356710 6914 52985423
Inflammatory marker increased 10.39 9.95 74 356655 6116 52986221
Peripheral sensory neuropathy 10.37 9.95 20 356709 7128 52985209
Polydipsia 10.37 9.95 5 356724 3435 52988902
Premature baby 10.32 9.95 188 356541 19613 52972724
Diverticulitis 10.32 9.95 313 356416 35488 52956849
Threatened labour 10.31 9.95 20 356709 863 52991474
Carcinoma in situ of skin 10.30 9.95 10 356719 219 52992118
Blood parathyroid hormone decreased 10.30 9.95 75 356654 6243 52986094
Mycobacterium tuberculosis complex test positive 10.25 9.95 31 356698 1780 52990557
Kidney transplant rejection 10.25 9.95 8 356721 4236 52988101
Intervertebral disc degeneration 10.18 9.95 143 356586 14155 52978182
Decreased insulin requirement 10.15 9.95 8 356721 131 52992206
Lung neoplasm 10.14 9.95 70 356659 5726 52986611
Haematocrit decreased 10.13 9.95 324 356405 37007 52955330
Cardiotoxicity 10.10 9.95 21 356708 7278 52985059
Pregnancy with contraceptive device 10.07 9.95 10 356719 4711 52987626
Osteoporotic fracture 10.07 9.95 46 356683 3225 52989112
Blood pressure increased 10.07 9.95 1080 355649 139399 52852938
Hyperthyroidism 10.05 9.95 49 356680 13024 52979313
Respiratory acidosis 10.05 9.95 17 356712 6371 52985966
Intracranial pressure increased 10.01 9.95 10 356719 4696 52987641
Pulmonary alveolar haemorrhage 9.99 9.95 9 356720 4441 52987896
Plasma cell myeloma recurrent 9.99 9.95 3 356726 2754 52989583
Hyperthermia 9.98 9.95 27 356702 8542 52983795
Sinus bradycardia 9.96 9.95 57 356672 14544 52977793
Complication of device removal 9.95 9.95 8 356721 4174 52988163

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 490.56 10.18 749 132868 43795 32336114
Foetal exposure during pregnancy 284.80 10.18 565 133052 40736 32339173
Drug abuse 271.91 10.18 14 133603 80229 32299680
Arthralgia 223.88 10.18 1201 132416 147247 32232662
Toxicity to various agents 184.45 10.18 279 133338 177762 32202147
Completed suicide 174.29 10.18 81 133536 92436 32287473
Psoriatic arthropathy 152.63 10.18 268 133349 17592 32362317
Joint swelling 118.90 10.18 474 133143 51261 32328648
Drug interaction 114.87 10.18 484 133133 217701 32162208
Dysmorphism 110.99 10.18 92 133525 2701 32377208
Sickle cell anaemia with crisis 107.99 10.18 88 133529 2521 32377388
Premature baby 101.68 10.18 231 133386 18287 32361622
Enthesopathy 89.92 10.18 91 133526 3472 32376437
Exposure during pregnancy 88.77 10.18 146 133471 9083 32370826
Tenosynovitis 76.30 10.18 86 133531 3717 32376192
Acute kidney injury 74.60 10.18 809 132808 292659 32087250
Neonatal respiratory distress syndrome 73.53 10.18 88 133529 4059 32375850
Blood pressure fluctuation 72.15 10.18 214 133403 19921 32359988
Intentional overdose 71.48 10.18 41 133576 41560 32338349
Hypospadias 71.02 10.18 74 133543 2923 32376986
Atrial septal defect 70.10 10.18 113 133504 6912 32372997
Nasopharyngitis 67.30 10.18 471 133146 63316 32316593
Musculoskeletal stiffness 66.14 10.18 328 133289 38936 32340973
Speech disorder developmental 63.98 10.18 55 133562 1699 32378210
Synovitis 63.42 10.18 139 133478 10739 32369170
Drug reaction with eosinophilia and systemic symptoms 63.39 10.18 27 133590 32458 32347451
Overdose 59.24 10.18 173 133444 86904 32293005
Maternal drugs affecting foetus 58.83 10.18 80 133537 4197 32375712
Foetal anticonvulsant syndrome 57.86 10.18 42 133575 1009 32378900
Psoriasis 56.78 10.18 354 133263 45769 32334140
Pain 55.44 10.18 1080 132537 186476 32193433
Maternal exposure during pregnancy 54.70 10.18 78 133539 4279 32375630
Low birth weight baby 54.69 10.18 101 133516 6893 32373016
C-reactive protein abnormal 52.51 10.18 94 133523 6262 32373647
Tongue disorder 51.30 10.18 79 133538 4645 32375264
Hepatic function abnormal 50.56 10.18 66 133551 44774 32335135
Hypoglycaemia neonatal 49.40 10.18 47 133570 1661 32378248
Arthritis 48.56 10.18 228 133389 26464 32353445
Ventricular septal defect 48.27 10.18 68 133549 3689 32376220
Cryptorchism 48.08 10.18 49 133568 1885 32378024
Death 47.94 10.18 1202 132415 381315 31998594
Drug intolerance 47.84 10.18 362 133255 49873 32330036
Maternal exposure during breast feeding 47.18 10.18 45 133572 1595 32378314
Haemoglobin decreased 46.83 10.18 721 132896 118950 32260959
Small for dates baby 45.96 10.18 63 133554 3330 32376579
Serotonin syndrome 45.95 10.18 11 133606 19106 32360803
Suicide attempt 45.52 10.18 54 133563 38190 32341719
Autism spectrum disorder 43.76 10.18 46 133571 1836 32378073
Basal cell carcinoma 42.79 10.18 164 133453 17404 32362505
Coma 41.90 10.18 69 133548 42543 32337366
Drug resistance 41.84 10.18 21 133596 22944 32356965
Syndactyly 41.61 10.18 31 133586 776 32379133
Infusion related reaction 41.42 10.18 325 133292 45274 32334635
Pulmonary fibrosis 40.97 10.18 158 133459 16816 32363093
Arthropathy 40.11 10.18 191 133426 22298 32357611
Rhabdomyolysis 39.91 10.18 142 133475 67123 32312786
Exposure via breast milk 38.30 10.18 42 133575 1760 32378149
Palmar-plantar erythrodysaesthesia syndrome 37.98 10.18 9 133608 15740 32364169
Rheumatoid nodule 37.83 10.18 45 133572 2062 32377847
Febrile neutropenia 37.33 10.18 313 133304 119253 32260656
Osteoarthritis 37.02 10.18 170 133447 19549 32360360
Intentional product misuse 35.79 10.18 58 133559 35993 32343916
Drug dependence 35.14 10.18 27 133590 23457 32356452
Lower respiratory tract infection 35.08 10.18 223 133394 29020 32350889
Blood pressure systolic increased 34.93 10.18 153 133464 17243 32362666
Alanine aminotransferase abnormal 34.65 10.18 52 133565 2988 32376921
Pain in extremity 34.16 10.18 682 132935 118219 32261690
Product use in unapproved indication 34.11 10.18 214 133403 86990 32292919
Pancytopenia 33.52 10.18 544 133073 90691 32289218
Drug withdrawal syndrome 33.26 10.18 21 133596 20210 32359699
Bradycardia 33.22 10.18 166 133451 71396 32308513
Blood pressure increased 32.92 10.18 483 133134 78871 32301038
Cardiac failure 32.83 10.18 231 133386 91442 32288467
Respiratory arrest 32.12 10.18 43 133574 28865 32351044
Foot deformity 32.11 10.18 59 133558 4011 32375898
Delirium 31.79 10.18 85 133532 43961 32335948
Learning disorder 31.55 10.18 27 133590 829 32379080
Angioedema 31.02 10.18 64 133553 36225 32343684
Hypermobility syndrome 30.84 10.18 19 133598 344 32379565
Tendonitis 30.49 10.18 92 133525 8643 32371266
Joint effusion 30.45 10.18 60 133557 4299 32375610
Talipes 30.30 10.18 38 133579 1840 32378069
Serum ferritin increased 30.27 10.18 73 133544 6006 32373903
Congenital hand malformation 30.25 10.18 22 133595 530 32379379
Large for dates baby 29.84 10.18 27 133590 894 32379015
Blood pressure systolic abnormal 29.62 10.18 40 133577 2084 32377825
Peripheral swelling 28.74 10.18 417 133200 67928 32311981
Developmental delay 28.61 10.18 44 133573 2584 32377325
Renal failure 28.59 10.18 385 133232 134093 32245816
Hyperglycaemia 28.54 10.18 73 133544 38318 32341591
Skin cancer 27.93 10.18 90 133527 8760 32371149
Foetal growth restriction 27.75 10.18 55 133562 3957 32375952
Loss of personal independence in daily activities 27.61 10.18 197 133420 26636 32353273
Injection site pain 27.51 10.18 231 133386 32827 32347082
Musculoskeletal pain 26.60 10.18 223 133394 31674 32348235
Agitation 26.43 10.18 133 133484 57103 32322806
Suicidal ideation 26.36 10.18 75 133542 38008 32341901
Intellectual disability 26.28 10.18 28 133589 1135 32378774
Knee arthroplasty 26.11 10.18 68 133549 5869 32374040
Caesarean section 24.97 10.18 37 133580 2102 32377807
Somnolence 24.73 10.18 290 133327 103507 32276402
Language disorder 24.68 10.18 35 133582 1910 32377999
Joint laxity 24.62 10.18 15 133602 266 32379643
Motor developmental delay 24.02 10.18 19 133598 521 32379388
Hand deformity 23.96 10.18 36 133581 2071 32377838
Knee deformity 23.86 10.18 19 133598 526 32379383
Pathogen resistance 23.81 10.18 5 133612 9505 32370404
Hypoglycaemia 23.63 10.18 129 133488 54253 32325656
Blood pressure diastolic decreased 23.45 10.18 74 133543 7123 32372786
Cytomegalovirus infection 23.42 10.18 43 133574 25421 32354488
Sedation 23.30 10.18 25 133592 18501 32361408
Infective pulmonary exacerbation of cystic fibrosis 23.28 10.18 4 133613 8775 32371134
Arthritis bacterial 23.27 10.18 56 133561 4601 32375308
Altered state of consciousness 23.16 10.18 34 133583 21963 32357946
Selective eating disorder 23.16 10.18 32 133585 1704 32378205
Multiple organ dysfunction syndrome 23.10 10.18 180 133437 69674 32310235
Medical device implantation 23.03 10.18 19 133598 554 32379355
Psychotic disorder 22.88 10.18 37 133580 22983 32356926
Shock 22.82 10.18 40 133577 24074 32355835
Polyarthritis 22.67 10.18 51 133566 4009 32375900
Lactic acidosis 22.51 10.18 67 133550 33469 32346440
Cardiac arrest 22.43 10.18 272 133345 96504 32283405
Constipation 22.31 10.18 375 133242 125998 32253911
Agitation neonatal 22.24 10.18 25 133592 1077 32378832
Body temperature decreased 22.21 10.18 97 133520 10917 32368992
Poisoning 22.21 10.18 9 133608 11149 32368760
Juvenile idiopathic arthritis 21.80 10.18 29 133588 1489 32378420
Depressed level of consciousness 21.17 10.18 91 133526 40756 32339153
Renal impairment 21.12 10.18 259 133358 91713 32288196
Anal fistula 20.93 10.18 52 133565 4359 32375550
Jaundice neonatal 20.87 10.18 25 133592 1154 32378755
Wound 20.76 10.18 108 133509 13059 32366850
Congenital anomaly 20.35 10.18 27 133590 1383 32378526
Patent ductus arteriosus 20.32 10.18 43 133574 3242 32376667
Dyslexia 20.27 10.18 14 133603 310 32379599
Lacrimal disorder 19.96 10.18 14 133603 318 32379591
Hydrocele 19.81 10.18 34 133583 2190 32377719
Plagiocephaly 19.78 10.18 15 133602 386 32379523
Blood creatine phosphokinase increased 19.69 10.18 108 133509 45368 32334541
Hyperbilirubinaemia neonatal 19.54 10.18 19 133598 690 32379219
Rash maculo-papular 19.53 10.18 55 133562 27967 32351942
Substance abuse 19.38 10.18 3 133614 7104 32372805
Renal aplasia 19.34 10.18 19 133598 699 32379210
Astigmatism 19.22 10.18 22 133595 967 32378942
Blood pressure diastolic abnormal 19.09 10.18 34 133583 2256 32377653
Vitamin D deficiency 18.95 10.18 61 133556 5933 32373976
Weight decrease neonatal 18.87 10.18 14 133603 348 32379561
Congenital bladder anomaly 18.62 10.18 13 133604 293 32379616
Off label use 18.54 10.18 1050 132567 305270 32074639
Limb reduction defect 18.43 10.18 13 133604 298 32379611
Grip strength decreased 18.30 10.18 34 133583 2331 32377578
Post procedural infection 18.24 10.18 52 133565 4733 32375176
Foetal disorder 18.22 10.18 19 133598 751 32379158
Infection 18.07 10.18 466 133151 84249 32295660
Acute hepatic failure 18.05 10.18 16 133601 12953 32366956
Joint stiffness 18.03 10.18 85 133532 9880 32370029
Back disorder 17.98 10.18 63 133554 6400 32373509
Haemangioma congenital 17.96 10.18 16 133601 519 32379390
Multiple congenital abnormalities 17.93 10.18 16 133601 520 32379389
Malignant melanoma 17.89 10.18 73 133544 7973 32371936
Bronchiolitis 17.87 10.18 38 133579 2875 32377034
Arthrodesis 17.79 10.18 15 133602 451 32379458
Blood pressure diastolic increased 17.76 10.18 43 133574 3547 32376362
Therapeutic product effect decreased 17.58 10.18 200 133417 30817 32349092
Hypotonia neonatal 17.52 10.18 23 133594 1166 32378743
Neuroleptic malignant syndrome 17.50 10.18 28 133589 17467 32362442
Cleft lip 17.39 10.18 13 133604 327 32379582
Bradycardia neonatal 17.35 10.18 21 133596 980 32378929
Heart rate decreased 17.34 10.18 169 133448 25031 32354878
Contraindicated product administered 17.33 10.18 136 133481 18940 32360969
Pneumonia 17.30 10.18 1689 131928 353563 32026346
Weight decreased 17.17 10.18 835 132782 163983 32215926
Proteinuria 17.15 10.18 28 133589 17327 32362582
Haematocrit decreased 16.98 10.18 202 133415 31460 32348449
Neck mass 16.98 10.18 26 133591 1521 32378388
Joint range of motion decreased 16.97 10.18 60 133557 6122 32373787
Umbilical hernia 16.86 10.18 47 133570 4223 32375686
Otitis media 16.81 10.18 36 133581 2737 32377172
Oropharyngeal pain 16.81 10.18 200 133417 31152 32348757
Hallucination 16.74 10.18 137 133480 52482 32327427
Diaphragmatic disorder 16.67 10.18 22 133595 1121 32378788
Ankyloglossia congenital 16.65 10.18 12 133605 285 32379624
Injection site bruising 16.64 10.18 70 133547 7750 32372159
Red blood cell sedimentation rate increased 16.56 10.18 70 133547 7765 32372144
Pyrexia 16.52 10.18 1113 132504 318855 32061054
Septic arthritis staphylococcal 16.42 10.18 15 133602 503 32379406
Crohn's disease 16.35 10.18 47 133570 4298 32375611
Dysgraphia 16.28 10.18 29 133588 1924 32377985
Intentional self-injury 16.14 10.18 20 133597 13880 32366029
Cellulitis 16.07 10.18 293 133324 49937 32329972
Urticaria 16.01 10.18 162 133455 59452 32320457
Arthritis infective 15.90 10.18 37 133580 2975 32376934
Disease progression 15.89 10.18 256 133361 86606 32293303
Drug withdrawal syndrome neonatal 15.85 10.18 41 133576 3523 32376386
Strabismus 15.74 10.18 24 133593 1399 32378510
Aggression 15.73 10.18 96 133521 39293 32340616
Lung neoplasm malignant 15.73 10.18 116 133501 15847 32364062
Product quality issue 15.54 10.18 35 133582 19198 32360711
Arnold-Chiari malformation 15.49 10.18 12 133605 319 32379590
Tuberculosis 15.46 10.18 74 133543 8655 32371254
Hernia pain 15.45 10.18 11 133606 256 32379653
Status epilepticus 15.33 10.18 16 133601 11990 32367919
Hepatocellular injury 15.31 10.18 53 133564 25265 32354644
Hepatic failure 15.30 10.18 85 133532 35595 32344314
Maternal exposure timing unspecified 15.28 10.18 13 133604 396 32379513
C-reactive protein decreased 15.20 10.18 26 133591 1670 32378239
Neurotoxicity 15.19 10.18 24 133593 15046 32364863
Electrocardiogram QT prolonged 15.12 10.18 98 133519 39543 32340366
Diabetic ketoacidosis 15.01 10.18 32 133585 17900 32362009
Foetal heart rate deceleration abnormality 14.90 10.18 14 133603 487 32379422
Microcephaly 14.86 10.18 17 133600 747 32379162
Inflammation 14.82 10.18 160 133457 24333 32355576
Oesophageal fibrosis 14.80 10.18 9 133608 159 32379750
Congenital foot malformation 14.78 10.18 11 133606 275 32379634
Immunodeficiency 14.76 10.18 48 133569 4694 32375215
Finger deformity 14.71 10.18 21 133596 1153 32378756
Foetal distress syndrome 14.42 10.18 20 133597 1069 32378840
Poor venous access 14.40 10.18 36 133581 3030 32376879
Tonsil cancer 14.38 10.18 18 133599 870 32379039
Prostate cancer 14.33 10.18 174 133443 27232 32352677
Cholestasis 14.14 10.18 60 133557 26973 32352936
Injection site swelling 14.01 10.18 77 133540 9507 32370402
Vascular insufficiency 13.98 10.18 12 133605 370 32379539
Peripheral artery thrombosis 13.97 10.18 30 133587 2285 32377624
Blood parathyroid hormone decreased 13.97 10.18 17 133600 798 32379111
Hypertelorism 13.88 10.18 14 133603 532 32379377
Blood insulin increased 13.87 10.18 12 133605 374 32379535
Cleft palate 13.84 10.18 15 133602 620 32379289
C-reactive protein increased 13.82 10.18 276 133341 47826 32332083
Scoliosis 13.80 10.18 29 133588 2176 32377733
Diverticular perforation 13.71 10.18 37 133580 3261 32376648
Mouth ulceration 13.70 10.18 87 133530 11314 32368595
Pectus excavatum 13.61 10.18 9 133608 185 32379724
Respiratory rate increased 13.56 10.18 75 133542 9282 32370627
Ear malformation 13.50 10.18 11 133606 315 32379594
Mean cell volume increased 13.39 10.18 29 133588 2222 32377687
Spinal disorder 13.35 10.18 40 133577 3743 32376166
Anal atresia 13.32 10.18 11 133606 321 32379588
Haemolysis 13.26 10.18 65 133552 7676 32372233
Wrong technique in product usage process 13.20 10.18 87 133530 34972 32344937
Dyspraxia 13.18 10.18 11 133606 326 32379583
Pleural fibrosis 13.15 10.18 23 133594 1504 32378405
Palindromic rheumatism 13.12 10.18 9 133608 197 32379712
Ear infection 13.12 10.18 69 133548 8379 32371530
Hypertriglyceridaemia 13.07 10.18 10 133607 8709 32371200
Disseminated intravascular coagulation 13.03 10.18 50 133567 23126 32356783
Radiation inflammation 13.03 10.18 8 133609 144 32379765
Venoocclusive liver disease 13.02 10.18 7 133610 7358 32372551
Maternal exposure before pregnancy 12.99 10.18 13 133604 489 32379420
Agranulocytosis 12.98 10.18 51 133566 23426 32356483
Neonatal seizure 12.97 10.18 13 133604 490 32379419
Back pain 12.92 10.18 569 133048 110484 32269425
Stevens-Johnson syndrome 12.83 10.18 37 133580 18672 32361237
Emphysema 12.82 10.18 77 133540 9820 32370089
Gangrene neonatal 12.81 10.18 9 133608 205 32379704
Red blood cell sedimentation rate 12.80 10.18 13 133604 498 32379411
Cerebral haemorrhage 12.70 10.18 87 133530 34660 32345249
Sinusitis 12.67 10.18 216 133401 36344 32343565
Pulmonary artery stenosis congenital 12.63 10.18 13 133604 506 32379403
Skin lesion 12.61 10.18 133 133484 20108 32359801
Haemangioma 12.61 10.18 25 133592 1799 32378110
Attention deficit hyperactivity disorder 12.59 10.18 28 133589 2184 32377725
Excessive cerumen production 12.59 10.18 10 133607 276 32379633
Localised infection 12.57 10.18 106 133511 15081 32364828
Asthma 12.56 10.18 118 133499 43947 32335962
Moaning 12.56 10.18 16 133601 787 32379122
Limb malformation 12.53 10.18 13 133604 511 32379398
Behaviour disorder 12.49 10.18 38 133579 3586 32376323
Respiratory failure 12.48 10.18 340 133277 106842 32273067
Osteonecrosis of jaw 12.36 10.18 39 133578 19127 32360782
Kidney infection 12.22 10.18 47 133570 4994 32374915
Red blood cell count decreased 12.20 10.18 171 133446 27642 32352267
Spina bifida 12.14 10.18 11 133606 365 32379544
Lung cancer metastatic 12.04 10.18 31 133586 2657 32377252
Tachycardia 11.97 10.18 241 133376 78847 32301062
Abnormal behaviour 11.93 10.18 62 133555 26404 32353505
Cholelithiasis 11.92 10.18 135 133482 20777 32359132
Nasal disorder 11.64 10.18 22 133595 1528 32378381
Hyperammonaemia 11.58 10.18 5 133612 5964 32373945
Hypocalcaemia 11.55 10.18 52 133565 23002 32356907
Incorrect route of product administration 11.51 10.18 19 133598 11707 32368202
Steatorrhoea 11.46 10.18 15 133602 758 32379151
Congenital diaphragmatic hernia 11.43 10.18 9 133608 245 32379664
Anaemia vitamin B12 deficiency 11.42 10.18 10 133607 317 32379592
Dermatitis psoriasiform 11.35 10.18 19 133598 1199 32378710
Joint instability 11.35 10.18 11 133606 398 32379511
Hepatic encephalopathy 11.32 10.18 28 133589 14867 32365042
Hepatic siderosis 11.28 10.18 8 133609 185 32379724
Pancreatic duct stenosis 11.17 10.18 8 133609 188 32379721
Anti-erythropoietin antibody positive 11.15 10.18 16 133601 883 32379026
Aspergillus infection 11.13 10.18 19 133598 11555 32368354
Foetal hypokinesia 11.12 10.18 11 133606 408 32379501
Non-Hodgkin's lymphoma 11.11 10.18 23 133594 1707 32378202
Lipase increased 11.09 10.18 13 133604 9244 32370665
Sexual dysfunction 11.08 10.18 6 133611 6283 32373626
Drug-induced liver injury 11.05 10.18 56 133561 24007 32355902
Polydactyly 11.05 10.18 19 133598 1226 32378683
Lung neoplasm 11.03 10.18 43 133574 4598 32375311
Transfusion-related circulatory overload 11.03 10.18 8 133609 192 32379717
Erectile dysfunction 11.03 10.18 43 133574 19796 32360113
Oesophageal atresia 11.02 10.18 12 133605 499 32379410
Heart rate irregular 10.99 10.18 97 133520 13981 32365928
Oxygen saturation decreased 10.96 10.18 267 133350 47832 32332077
Congenital hydronephrosis 10.95 10.18 14 133603 691 32379218
Brain oedema 10.95 10.18 23 133594 12937 32366972
Injection site erythema 10.90 10.18 100 133517 14568 32365341
Anaphylactic shock 10.85 10.18 29 133588 15005 32364904
Fistula 10.85 10.18 48 133569 5431 32374478
Injection site haemorrhage 10.83 10.18 66 133551 8462 32371447
Gross motor delay 10.80 10.18 9 133608 266 32379643
Hepatic enzyme increased 10.80 10.18 213 133404 36824 32343085
Progressive multifocal leukoencephalopathy 10.77 10.18 14 133603 9517 32370392
Tooth malformation 10.75 10.18 7 133610 140 32379769
Congenital musculoskeletal anomaly 10.75 10.18 9 133608 268 32379641
Retinopathy hypertensive 10.69 10.18 9 133608 270 32379639
Influenza 10.66 10.18 256 133361 45758 32334151
Subdural haematoma 10.61 10.18 44 133573 19909 32360000
Toxic epidermal necrolysis 10.59 10.18 46 133571 20547 32359362
Granuloma skin 10.57 10.18 13 133604 617 32379292
Blood test abnormal 10.56 10.18 52 133565 6152 32373757
Low set ears 10.55 10.18 11 133606 435 32379474
Vitamin B12 deficiency 10.54 10.18 32 133585 3017 32376892
Upper respiratory tract infection 10.53 10.18 175 133442 29298 32350611
Transaminases increased 10.52 10.18 60 133557 24968 32354941
Renal injury 10.52 10.18 21 133596 12034 32367875
Pharyngitis 10.49 10.18 61 133556 7689 32372220
Placental insufficiency 10.44 10.18 6 133611 95 32379814
Irritability 10.42 10.18 59 133558 24595 32355314
Hypotension 10.42 10.18 756 132861 215354 32164555
Squamous cell carcinoma 10.41 10.18 79 133538 10889 32369020
Nerve compression 10.40 10.18 32 133585 3038 32376871
Inguinal hernia 10.39 10.18 62 133555 7890 32372019
Ulna fracture 10.38 10.18 10 133607 359 32379550
Necrotising fasciitis streptococcal 10.38 10.18 7 133610 149 32379760
Developmental coordination disorder 10.38 10.18 7 133610 149 32379760
Mesothelioma 10.36 10.18 11 133606 444 32379465
Pulmonary valve stenosis 10.33 10.18 10 133607 361 32379548
Appendix disorder 10.24 10.18 13 133604 637 32379272
Psychomotor retardation 10.20 10.18 31 133586 2924 32376985
Hypokalaemia 10.20 10.18 162 133455 54932 32324977
Nail pitting 10.19 10.18 8 133609 217 32379692

Pharmacologic Action:

SourceCodeDescription
ATC A11HA04 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC S01XA26 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
MeSH PA D003879 Dermatologic Agents
MeSH PA D018977 Micronutrients
MeSH PA D017319 Photosensitizing Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:47868 photosensitising agent
CHEBI has role CHEBI:67079 antiinflammatory agents
CHEBI has role CHEBI:75771 Mus musculus metabolite
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:76971 E.coli metabolites
CHEBI has role CHEBI:77182 food colourings
CHEBI has role CHEBI:78675 essential metabolite
CHEBI has role CHEBI:84087 human urinary metabolites
CHEBI has role CHEBI:75772 bakers yeast metabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Glutaric aciduria, type 2 off-label use 22886006 DOID:0060358
Glutaric aciduria, type 1 off-label use 76175005
Migraine Prevention off-label use
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Obstruction of bile duct contraindication 30144000
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Agoraphobia contraindication 70691001 DOID:593
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Panic disorder contraindication 371631005 DOID:594
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.13 acidic
pKa2 11.89 acidic
pKa3 13.48 acidic
pKa4 2.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Flavin reductase (NADPH) Enzyme WOMBAT-PK
Riboflavin kinase Kinase WOMBAT-PK
Riboflavin-binding protein Unclassified Kd 8.30 CHEMBL

External reference:

IDSource
4017778 VUID
N0000146139 NUI
D00050 KEGG_DRUG
4017633 VANDF
4017778 VANDF
4021901 VANDF
CHEBI:57986 CHEBI
RBF PDB_CHEM_ID
CHEMBL1534 ChEMBL_ID
CHEMBL1397833 ChEMBL_ID
6578 IUPHAR_LIGAND_ID
419 INN_ID
DB00140 DRUGBANK_ID
TLM2976OFR UNII
493570 PUBCHEM_CID
9346 RXNORM
5060 MMSL
5062 MMSL
5422 MMSL
5683 MMSL
d00409 MMSL
001059 NDDF
13235001 SNOMEDCT_US
329260009 SNOMEDCT_US
D012256 MESH_DESCRIPTOR_UI
C0035527 UMLSCUI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 3 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3.40 mg ORAL unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 3.40 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 3.40 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 3.40 mg ORAL Unapproved drug other 11 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1.80 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1.80 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.80 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 5 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1.80 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 3.40 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 1.60 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 3 mg ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 3 mg ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 3 mg ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 3 mg ORAL unapproved drug other 16 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 6 mg ORAL unapproved drug other 19 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 3 mg ORAL unapproved drug other 8 sections