thiamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2832 59-43-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiamine
  • vitamin B1
  • thiamine hydrochloride
  • thiamine mononitrate
  • thiamine (vit B1)
  • thiamine HCl
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.
  • Molecular weight: 265.35
  • Formula: C12H17N4OS
  • CLOGP: -5.67
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.91
  • ALOGS: -4.29
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O
50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 500 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.55 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 4.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1993 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1726.75 10.32 4403 535873 179323 62769423
Systemic lupus erythematosus 1626.69 10.32 4671 535605 204247 62744499
Glossodynia 1439.36 10.32 4048 536228 174828 62773918
Hand deformity 1172.81 10.32 3495 536781 155962 62792784
Arthropathy 1089.69 10.32 4416 535860 230376 62718370
Abdominal discomfort 1010.41 10.32 5387 534889 315498 62633248
Alopecia 1001.29 10.32 5575 534701 331961 62616785
Wound 971.12 10.32 3327 536949 159936 62788810
Completed suicide 941.64 10.32 80 540196 145593 62803153
Maternal exposure during pregnancy 866.53 10.32 3939 536337 216123 62732623
Rheumatoid arthritis 866.17 10.32 4359 535917 249460 62699286
Synovitis 768.86 10.32 3390 536886 183528 62765218
Toxicity to various agents 738.36 10.32 612 539664 246638 62702108
Anti-cyclic citrullinated peptide antibody positive 733.79 10.32 2417 537859 113795 62834951
Pericarditis 726.52 10.32 2617 537659 128962 62819784
Discomfort 722.28 10.32 3080 537196 164294 62784452
Swelling 719.98 10.32 4401 535875 270977 62677769
Contraindicated product administered 689.46 10.32 3662 536614 213986 62734760
Infusion related reaction 656.28 10.32 3947 536329 241574 62707172
Joint swelling 650.51 10.32 4892 535384 322774 62625972
Pain 565.23 10.32 9134 531142 731494 62217252
Death 524.54 10.32 1546 538730 372835 62575911
Duodenal ulcer perforation 461.22 10.32 1711 538565 85498 62863248
Rheumatoid factor positive 452.24 10.32 1663 538613 82743 62866003
Helicobacter infection 447.66 10.32 1768 538508 91017 62857729
Product use issue 431.63 10.32 3283 536993 217237 62731509
Drug interaction 399.42 10.32 845 539431 228286 62720460
Intentional overdose 398.70 10.32 74 540202 74078 62874668
Hepatic enzyme increased 393.55 10.32 3008 537268 199320 62749426
Drug abuse 373.94 10.32 80 540196 72438 62876308
Arthralgia 368.24 10.32 6846 533430 562864 62385882
Psoriatic arthropathy 335.76 10.32 1606 538670 89914 62858832
Musculoskeletal stiffness 331.05 10.32 2694 537582 181924 62766822
Therapeutic product effect decreased 313.05 10.32 2756 537520 190431 62758315
Febrile neutropenia 297.80 10.32 341 539935 118108 62830638
Drug intolerance 295.69 10.32 3964 536312 304697 62644049
Exposure during pregnancy 286.50 10.32 2284 537992 153263 62795483
Suicide attempt 255.65 10.32 99 540177 60819 62887927
Treatment failure 255.09 10.32 2703 537573 196340 62752406
Depressed level of consciousness 245.83 10.32 110 540166 61968 62886778
Hip arthroplasty 241.98 10.32 923 539353 46723 62902023
Knee arthroplasty 234.53 10.32 999 539277 53207 62895539
Hypersensitivity 222.83 10.32 3613 536663 289072 62659674
Overdose 220.56 10.32 401 539875 114677 62834069
Malignant neoplasm progression 217.91 10.32 226 540050 81895 62866851
Cardiac arrest 211.06 10.32 287 539989 92258 62856488
Acute kidney injury 205.74 10.32 1354 538922 262061 62686685
Rheumatic fever 202.58 10.32 815 539461 42296 62906450
Disease progression 197.96 10.32 472 539804 122286 62826460
Impaired healing 196.01 10.32 1519 538757 101023 62847723
Nasopharyngitis 186.90 10.32 3121 537155 251136 62697610
Neutropenia 183.96 10.32 814 539462 174191 62774555
Constipation 178.27 10.32 1151 539125 223792 62724954
Swollen joint count increased 176.98 10.32 691 539585 35363 62913383
Sedation 166.29 10.32 61 540215 38748 62909998
Blister 162.48 10.32 1755 538521 128059 62820687
Folliculitis 161.68 10.32 1089 539187 69228 62879518
Red blood cell sedimentation rate abnormal 160.88 10.32 450 539826 19332 62929414
Muscle injury 157.50 10.32 1024 539252 64321 62884425
Lactic acidosis 152.91 10.32 67 540209 38220 62910526
Nausea 150.21 10.32 5853 534423 848618 62100128
Fatigue 147.97 10.32 9089 531187 878939 62069807
Bradycardia 146.78 10.32 248 540028 72979 62875767
Cardiac failure 141.12 10.32 346 539930 88796 62859950
Hypotension 140.94 10.32 1561 538715 271043 62677703
Sleep disorder due to general medical condition, insomnia type 139.40 10.32 840 539436 51377 62897369
Sickle cell anaemia with crisis 137.97 10.32 210 540066 5793 62942953
Somnolence 134.64 10.32 928 539348 177757 62770989
Drug hypersensitivity 134.26 10.32 1849 538427 308838 62639908
Rash 131.60 10.32 5931 534345 554940 62393806
Renal failure 130.49 10.32 536 539740 117116 62831630
Irritable bowel syndrome 128.80 10.32 1167 539109 81245 62867501
Hyponatraemia 125.86 10.32 507 539769 111393 62837353
Respiratory arrest 124.37 10.32 61 540215 32584 62916162
Sopor 123.76 10.32 20 540256 22144 62926602
C-reactive protein abnormal 123.34 10.32 742 539534 45354 62903392
Drug reaction with eosinophilia and systemic symptoms 123.29 10.32 67 540209 33769 62914977
Electrocardiogram QT prolonged 122.67 10.32 198 540078 59332 62889414
Rhabdomyolysis 122.27 10.32 116 540160 43835 62904911
Neoplasm progression 121.68 10.32 80 540196 36348 62912398
Hyperhidrosis 121.65 10.32 488 539788 107348 62841398
Agitation 119.19 10.32 203 540073 59554 62889192
Intentional self-injury 117.69 10.32 36 540240 25651 62923095
Diarrhoea 117.55 10.32 4937 535339 710429 62238317
Lower respiratory tract infection 116.94 10.32 1676 538600 130631 62818115
Blood cholesterol increased 116.58 10.32 1269 539007 92763 62855983
Asthenia 115.09 10.32 2439 537837 381165 62567581
Osteoarthritis 113.76 10.32 1277 538999 94066 62854680
Anxiety 110.29 10.32 1251 539025 216290 62732456
Dyspnoea 109.21 10.32 4561 535715 656752 62291994
Cardio-respiratory arrest 107.79 10.32 217 540059 59742 62889004
Tremor 107.57 10.32 671 539605 131568 62817178
Vomiting 105.37 10.32 3800 536476 555817 62392929
Syncope 103.77 10.32 580 539696 116805 62831941
Tachycardia 103.26 10.32 586 539690 117570 62831176
Liver injury 101.80 10.32 871 539405 59649 62889097
Condition aggravated 100.05 10.32 4280 535996 397937 62550809
Arthritis 98.70 10.32 1459 538817 114462 62834284
Serotonin syndrome 98.53 10.32 61 540215 28621 62920125
Pregnancy 97.31 10.32 591 539685 36245 62912501
Type 2 diabetes mellitus 97.04 10.32 899 539377 62969 62885777
Psoriasis 96.28 10.32 1148 539128 85809 62862937
Thrombocytopenia 95.08 10.32 825 539451 150332 62798414
Cognitive disorder 93.65 10.32 210 540066 55605 62893141
Hypoglycaemia 90.53 10.32 239 540037 59826 62888920
Fibromyalgia 90.49 10.32 1065 539211 79355 62869391
Anaemia 87.82 10.32 1866 538410 291564 62657182
Intentional product misuse 87.61 10.32 248 540028 60669 62888077
No adverse event 86.92 10.32 136 540140 41269 62907477
Sedation complication 85.50 10.32 9 540267 13813 62934933
Coma 84.01 10.32 274 540002 64090 62884656
Renal impairment 83.95 10.32 426 539850 87929 62860817
Hepatic function abnormal 82.83 10.32 117 540159 37025 62911721
Drug resistance 82.70 10.32 46 540230 22887 62925859
Live birth 82.08 10.32 433 539843 25197 62923549
Orthostatic hypotension 81.55 10.32 113 540163 36047 62912699
Macular degeneration 80.78 10.32 54 540222 24322 62924424
Asthma 80.31 10.32 696 539580 126865 62821881
Contusion 79.33 10.32 1752 538524 148292 62800454
Intentional product use issue 79.32 10.32 1529 538747 126363 62822383
Hyperglycaemia 79.18 10.32 147 540129 41720 62907026
Drug dependence 78.79 10.32 56 540220 24427 62924319
Peripheral swelling 78.18 10.32 2882 537394 263060 62685686
Abortion spontaneous 77.16 10.32 675 539601 46520 62902226
Joint effusion 76.55 10.32 318 539958 16742 62932004
Ill-defined disorder 76.38 10.32 1046 539230 80709 62868037
Multiple sclerosis relapse 76.05 10.32 189 540087 48289 62900457
Multiple organ dysfunction syndrome 75.18 10.32 240 540036 56512 62892234
Myalgia 74.07 10.32 843 539433 145686 62803060
Drug ineffective for unapproved indication 73.31 10.32 110 540166 33953 62914793
Drug withdrawal syndrome 73.07 10.32 74 540202 27120 62921626
Creatinine renal clearance decreased 72.67 10.32 24 540252 16284 62932462
Device expulsion 72.08 10.32 116 540160 34806 62913940
Metabolic acidosis 72.05 10.32 174 540102 44895 62903851
Blood pressure diastolic abnormal 71.59 10.32 279 539997 14263 62934483
Respiratory failure 71.35 10.32 540 539736 101318 62847428
Blood pressure systolic abnormal 70.99 10.32 263 540013 13123 62935623
Blood pressure fluctuation 70.88 10.32 653 539623 45664 62903082
Altered state of consciousness 70.87 10.32 66 540210 25164 62923582
Dizziness 70.79 10.32 2965 537311 426960 62521786
Neuropathy peripheral 70.31 10.32 623 539653 113044 62835702
Product quality issue 69.55 10.32 124 540152 35741 62913005
Seizure 69.43 10.32 757 539519 131877 62816869
Hepatic failure 69.39 10.32 123 540153 35533 62913213
Angioedema 69.17 10.32 195 540081 47770 62900976
Metastases to bone 69.07 10.32 47 540229 20972 62927774
Hepatocellular injury 68.58 10.32 79 540197 27302 62921444
Chest discomfort 67.46 10.32 604 539672 109365 62839381
Anaphylactic reaction 67.26 10.32 311 539965 65789 62882957
Hypoxia 67.15 10.32 271 540005 59521 62889225
Cardiac failure congestive 67.15 10.32 485 539791 91948 62856798
Blood glucose increased 67.05 10.32 427 539849 83329 62865417
Neutrophil count decreased 66.32 10.32 251 540025 56155 62892591
Foot deformity 66.19 10.32 435 539841 27418 62921328
Cytomegalovirus infection 66.02 10.32 49 540227 20903 62927843
Drug ineffective 65.99 10.32 9986 530290 1034779 61913967
Disability assessment scale score increased 65.85 10.32 107 540169 3126 62945620
Cholestasis 65.36 10.32 93 540183 29341 62919405
Palmar-plantar erythrodysaesthesia syndrome 64.89 10.32 60 540216 22955 62925791
Red blood cell sedimentation rate increased 64.26 10.32 614 539662 43368 62905378
Sinusitis 64.12 10.32 2446 537830 224207 62724539
Balance disorder 62.77 10.32 440 539836 83982 62864764
Hyperkalaemia 62.56 10.32 243 540033 53960 62894786
Leukopenia 62.40 10.32 393 539883 76897 62871849
Vision blurred 62.19 10.32 492 539784 91432 62857314
Hallucination 61.21 10.32 249 540027 54568 62894178
Ejection fraction decreased 60.88 10.32 60 540216 22272 62926474
Basal cell carcinoma 60.46 10.32 427 539849 27564 62921182
Osteonecrosis of jaw 59.86 10.32 131 540145 34992 62913754
Dehydration 59.82 10.32 1076 539200 172278 62776468
Product use in unapproved indication 59.47 10.32 1119 539157 177961 62770785
Anaphylactic shock 59.39 10.32 68 540208 23565 62925181
Encephalopathy 57.94 10.32 154 540122 38466 62910280
Poisoning 57.91 10.32 22 540254 13678 62935068
Feeling abnormal 57.42 10.32 902 539374 147490 62801256
Diabetic ketoacidosis 57.17 10.32 54 540222 20451 62928295
Injection site erythema 56.99 10.32 1010 539266 82164 62866582
Loss of consciousness 56.81 10.32 687 539589 117434 62831312
Grip strength decreased 56.61 10.32 354 539922 21933 62926813
Insomnia 56.41 10.32 1397 538879 213855 62734891
Blood creatine phosphokinase increased 54.80 10.32 110 540166 30320 62918426
Blood pressure systolic increased 54.78 10.32 631 539645 46766 62901980
Myocardial infarction 54.76 10.32 564 539712 99329 62849417
Juvenile idiopathic arthritis 54.53 10.32 100 540176 3226 62945520
Pulmonary fibrosis 54.38 10.32 548 539728 39261 62909485
Weight increased 54.34 10.32 2727 537549 258065 62690681
Mydriasis 54.33 10.32 17 540259 11939 62936807
COVID-19 54.32 10.32 658 539618 112445 62836301
Cytokine release syndrome 54.14 10.32 27 540249 14287 62934459
Infection 53.81 10.32 2425 537851 226748 62721998
Restlessness 53.44 10.32 106 540170 29347 62919399
Osteoporosis 53.30 10.32 733 539543 56605 62892141
Stomatitis 53.26 10.32 1552 538724 137173 62811573
Wrong technique in product usage process 52.93 10.32 312 539964 62028 62886718
Blood calcium decreased 52.61 10.32 90 540186 26361 62922385
Bone erosion 52.47 10.32 293 539983 17424 62931322
Gamma-glutamyltransferase increased 51.58 10.32 135 540141 33896 62914850
Hypokalaemia 51.35 10.32 600 539676 103204 62845542
Shock 51.24 10.32 75 540201 23388 62925358
Metastases to liver 51.20 10.32 76 540200 23563 62925183
Suicidal ideation 51.11 10.32 316 539960 62105 62886641
White blood cell count decreased 51.01 10.32 854 539422 138250 62810496
Joint laxity 50.80 10.32 82 540194 2382 62946364
Blood pressure decreased 50.76 10.32 334 539942 64688 62884058
Extrapyramidal disorder 50.33 10.32 25 540251 13259 62935487
Respiratory depression 50.19 10.32 27 540249 13688 62935058
Disseminated intravascular coagulation 49.87 10.32 53 540223 18998 62929748
Ventricular tachycardia 49.65 10.32 58 540218 19921 62928825
Disturbance in attention 49.53 10.32 163 540113 38026 62910720
Torsade de pointes 49.28 10.32 26 540250 13325 62935421
Joint range of motion decreased 48.51 10.32 455 539821 31973 62916773
Cerebral haemorrhage 48.04 10.32 120 540156 30609 62918137
Caesarean section 48.02 10.32 278 539998 16754 62931992
Dysphagia 47.79 10.32 502 539774 88083 62860663
Joint destruction 47.70 10.32 139 540137 6113 62942633
Platelet count decreased 47.60 10.32 698 539578 115424 62833322
Drug level increased 47.42 10.32 75 540201 22661 62926085
Premature labour 46.95 10.32 221 540055 12283 62936463
Injection site reaction 46.84 10.32 729 539547 57795 62890951
Drug tolerance decreased 45.92 10.32 280 539996 17193 62931553
Urticaria 45.64 10.32 1068 539208 164734 62784012
Loss of personal independence in daily activities 45.53 10.32 1117 539159 96173 62852573
Inflammation 45.47 10.32 967 539309 81306 62867440
Accidental exposure to product 45.24 10.32 104 540172 27301 62921445
Palpitations 45.13 10.32 681 539595 112089 62836657
Hypothermia 45.12 10.32 30 540246 13551 62935195
Pulmonary embolism 44.88 10.32 710 539566 115974 62832772
Myelosuppression 44.14 10.32 84 540192 23619 62925127
Respiratory disorder 43.96 10.32 177 540099 38905 62909841
Disorientation 43.55 10.32 180 540096 39272 62909474
C-reactive protein increased 43.02 10.32 1083 539193 93624 62855122
Muscle spasticity 42.57 10.32 75 540201 21719 62927027
Neurotoxicity 42.57 10.32 49 540227 16941 62931805
Abnormal behaviour 42.52 10.32 73 540203 21353 62927393
Polyarthritis 42.33 10.32 185 540091 9961 62938785
Mental status changes 42.27 10.32 183 540093 39416 62909330
Injection site pruritus 42.03 10.32 577 539699 44539 62904207
Fluid retention 41.98 10.32 316 539960 59370 62889376
Akathisia 41.57 10.32 13 540263 9133 62939613
Device difficult to use 41.53 10.32 29 540247 12767 62935979
Emotional distress 41.48 10.32 140 540136 32409 62916337
Blood alkaline phosphatase increased 41.47 10.32 206 540070 42761 62905985
Speech disorder 40.83 10.32 192 540084 40437 62908309
Unresponsive to stimuli 40.71 10.32 149 540127 33667 62915079
Posterior reversible encephalopathy syndrome 40.33 10.32 53 540223 17292 62931454
Flushing 40.31 10.32 426 539850 74661 62874085
Vertigo 39.82 10.32 322 539954 59565 62889181
Acute hepatic failure 39.62 10.32 59 540217 18268 62930478
Ascites 39.46 10.32 195 540081 40533 62908213
Chronic kidney disease 39.18 10.32 226 540050 45172 62903574
Disability 39.11 10.32 279 539997 18068 62930678
Depression 38.93 10.32 1325 538951 195167 62753579
Pain in jaw 38.91 10.32 214 540062 43282 62905464
Polyneuropathy 38.85 10.32 40 540236 14549 62934197
Blood bilirubin increased 38.82 10.32 173 540103 36967 62911779
Stress cardiomyopathy 38.59 10.32 16 540260 9434 62939312
Thrombotic microangiopathy 38.35 10.32 21 540255 10540 62938206
Dysarthria 38.28 10.32 210 540066 42501 62906245
Blood pressure diastolic decreased 38.28 10.32 327 539949 22379 62926367
Disease recurrence 38.20 10.32 117 540159 27913 62920833
Gestational diabetes 38.06 10.32 157 540119 8239 62940507
Foetal exposure during pregnancy 38.05 10.32 428 539848 31534 62917212
Rheumatoid nodule 37.81 10.32 263 540013 16892 62931854
Neck deformity 37.62 10.32 66 540210 2055 62946691
Parkinsonism 37.55 10.32 21 540255 10418 62938328
Diabetes mellitus inadequate control 37.49 10.32 44 540232 15082 62933664
Schizophrenia 37.30 10.32 19 540257 9933 62938813
Sepsis 37.11 10.32 1005 539271 152118 62796628
Toxic skin eruption 37.03 10.32 33 540243 12852 62935894
Hypomania 36.98 10.32 5 540271 6325 62942421
Respiratory distress 36.79 10.32 156 540120 33795 62914951
Hepatotoxicity 36.66 10.32 176 540100 36865 62911881
Multiple fractures 36.61 10.32 158 540118 8460 62940286
Exposure to toxic agent 36.26 10.32 3 540273 5584 62943162
Withdrawal syndrome 36.25 10.32 72 540204 19925 62928821
Product administration error 36.17 10.32 86 540190 22311 62926435
Bone pain 35.78 10.32 295 539981 54346 62894400
Adverse event 35.71 10.32 789 539487 66770 62881976
Decreased appetite 35.62 10.32 1759 538517 249293 62699453
Tuberculosis 35.62 10.32 189 540087 11022 62937724
Psychotic disorder 35.27 10.32 107 540169 25605 62923141
Pulmonary oedema 35.14 10.32 298 539978 54575 62894171
Haematotoxicity 34.99 10.32 18 540258 9358 62939388
Second primary malignancy 34.92 10.32 12 540264 7941 62940805
Agranulocytosis 34.91 10.32 104 540172 25030 62923716
Metastases to central nervous system 34.82 10.32 36 540240 13069 62935677
Dyskinesia 34.71 10.32 147 540129 31855 62916891
Cerebrovascular accident 34.61 10.32 679 539597 107345 62841401
Brain oedema 34.43 10.32 42 540234 14153 62934593
Pyrexia 34.43 10.32 3492 536784 466986 62481760
Inappropriate antidiuretic hormone secretion 34.18 10.32 49 540227 15413 62933333
Accidental overdose 34.17 10.32 94 540182 23215 62925531
Joint stiffness 34.06 10.32 523 539753 41346 62907400
Dysgeusia 33.95 10.32 245 540031 46465 62902281
Blood creatinine increased 33.95 10.32 534 539742 87310 62861436
Eosinophilia 33.94 10.32 91 540185 22665 62926081
Arrhythmia 33.93 10.32 188 540088 37952 62910794
Pancreatitis acute 33.83 10.32 118 540158 27048 62921698
Aspartate aminotransferase increased 33.82 10.32 552 539724 89725 62859021
Bronchospasm 33.27 10.32 60 540216 17220 62931526
Gastrointestinal disorder 33.05 10.32 1399 538877 129840 62818906
Maternal drugs affecting foetus 33.00 10.32 109 540167 5133 62943613
Transplant rejection 32.96 10.32 26 540250 10754 62937992
Miosis 32.45 10.32 11 540265 7342 62941404
Hospitalisation 32.28 10.32 519 539757 84562 62864184
Atrial fibrillation 32.17 10.32 751 539525 115885 62832861
Tenderness 31.90 10.32 313 539963 22265 62926481
Alanine aminotransferase increased 31.83 10.32 657 539619 103113 62845633
Mania 31.71 10.32 35 540241 12332 62936414
Haemorrhage 31.63 10.32 349 539927 60673 62888073
Mobility decreased 31.52 10.32 1296 538980 119863 62828883
Obstructive airways disorder 31.46 10.32 82 540194 20617 62928129
Nodule 31.44 10.32 295 539981 20731 62928015
Dystonia 31.34 10.32 43 540233 13776 62934970
Forced expiratory volume decreased 31.34 10.32 3 540273 4965 62943781
Panic attack 31.30 10.32 92 540184 22239 62926507
Lupus-like syndrome 31.11 10.32 230 540046 15065 62933681
Tumour lysis syndrome 31.04 10.32 19 540257 8971 62939775
Off label use 31.04 10.32 5156 535120 669306 62279440
Pulmonary arterial hypertension 30.94 10.32 94 540182 22483 62926263
Colitis 30.87 10.32 264 540012 48264 62900482
Irritability 30.56 10.32 152 540124 31542 62917204
Atrioventricular block complete 30.55 10.32 16 540260 8235 62940511
Laryngitis 30.55 10.32 248 540028 16719 62932027
Maternal exposure before pregnancy 30.49 10.32 137 540139 7466 62941280
Hemiparesis 30.45 10.32 99 540177 23183 62925563
Device use error 30.42 10.32 6 540270 5755 62942991
Ventricular septal defect 30.26 10.32 94 540182 4284 62944462
General physical health deterioration 30.21 10.32 2045 538231 199357 62749389
Depressed mood 30.10 10.32 209 540067 39982 62908764
Acute generalised exanthematous pustulosis 30.05 10.32 30 540246 11069 62937677
Dyspnoea exertional 30.03 10.32 348 539928 59954 62888792
Face oedema 30.01 10.32 81 540195 20131 62928615
Coagulopathy 30.00 10.32 83 540193 20461 62928285
Neuroleptic malignant syndrome 29.96 10.32 35 540241 12021 62936725
Pleural effusion 29.82 10.32 586 539690 92624 62856122
Melaena 29.63 10.32 145 540131 30220 62918526
Asphyxia 29.54 10.32 8 540268 6173 62942573
Joint dislocation 29.24 10.32 266 540010 18534 62930212
Injection site swelling 29.21 10.32 568 539708 47004 62901742
Chronic sinusitis 29.09 10.32 40 540236 12803 62935943
Proteinuria 28.98 10.32 76 540200 19069 62929677
Ischaemic stroke 28.96 10.32 69 540207 17888 62930858
Ventricular fibrillation 28.90 10.32 35 540241 11832 62936914
Gastrointestinal haemorrhage 28.89 10.32 501 539775 80675 62868071
Musculoskeletal pain 28.76 10.32 1007 539269 91270 62857476
Enthesopathy 28.60 10.32 147 540129 8467 62940279
Metastases to lung 28.59 10.32 40 540236 12710 62936036
International normalised ratio increased 28.45 10.32 255 540021 46170 62902576
Status epilepticus 28.35 10.32 54 540222 15179 62933567
Heart rate decreased 28.32 10.32 545 539731 45015 62903731
Procedural pain 28.01 10.32 92 540184 21477 62927269
Hyperlipidaemia 27.89 10.32 80 540196 19491 62929255
Pain in extremity 27.81 10.32 3225 537051 328261 62620485
Latent tuberculosis 27.81 10.32 66 540210 2561 62946185
Wheelchair user 27.73 10.32 117 540159 6202 62942544
Substance abuse 27.61 10.32 4 540272 4803 62943943
Cytopenia 27.43 10.32 35 540241 11566 62937180
Haemophagocytic lymphohistiocytosis 27.33 10.32 30 540246 10597 62938149
Sinus tachycardia 27.24 10.32 110 540166 24158 62924588
Back pain 27.19 10.32 1908 538368 262237 62686509
Ankylosing spondylitis 26.99 10.32 167 540109 10307 62938439
Lymphocyte count decreased 26.99 10.32 149 540127 30108 62918638
Prescribed underdose 26.96 10.32 378 539898 29311 62919435
Erythema multiforme 26.95 10.32 28 540248 10141 62938605
Device related infection 26.91 10.32 105 540171 23287 62925459
Chest pain 26.88 10.32 1533 538743 214426 62734320
Limb deformity 26.80 10.32 85 540191 3917 62944829
Graft versus host disease 26.74 10.32 12 540264 6751 62941995
Blood pressure diastolic increased 26.68 10.32 161 540115 9849 62938897
Rhinitis allergic 26.09 10.32 37 540239 11690 62937056
Aggression 26.06 10.32 107 540169 23391 62925355
Aphasia 26.01 10.32 169 540107 32831 62915915
Localised infection 25.98 10.32 381 539895 29829 62918917
Tachypnoea 25.94 10.32 69 540207 17233 62931513
Cerebral infarction 25.76 10.32 110 540166 23783 62924963
Temperature regulation disorder 25.66 10.32 10 540266 6122 62942624
Peripheral venous disease 25.62 10.32 222 540054 15255 62933491
Nightmare 25.53 10.32 81 540195 19113 62929633
Small for dates baby 25.43 10.32 80 540196 3671 62945075
Paralysis 25.41 10.32 28 540248 9872 62938874
Angina pectoris 25.28 10.32 151 540125 29927 62918819
Personality disorder 25.12 10.32 9 540267 5802 62942944
Bronchopulmonary aspergillosis 24.95 10.32 22 540254 8613 62940133
Paradoxical drug reaction 24.94 10.32 3 540273 4149 62944597
Acute graft versus host disease 24.71 10.32 4 540272 4424 62944322
Acute myeloid leukaemia 24.50 10.32 70 540206 17077 62931669
Deep vein thrombosis 24.40 10.32 535 539741 83265 62865481
Facet joint syndrome 24.39 10.32 182 540094 11956 62936790
Malignant mediastinal neoplasm 24.37 10.32 44 540232 1402 62947344
Smear cervix abnormal 23.93 10.32 67 540209 2879 62945867
Injection site bruising 23.93 10.32 495 539781 41415 62907331
Premature rupture of membranes 23.93 10.32 95 540181 4898 62943848
Obesity 23.92 10.32 373 539903 29579 62919167
Anuria 23.79 10.32 44 540232 12507 62936239
Pre-eclampsia 23.78 10.32 146 540130 8987 62939759
Haemorrhage intracranial 23.74 10.32 49 540227 13370 62935376
Haemoptysis 23.73 10.32 145 540131 28581 62920165
Bone marrow failure 23.60 10.32 149 540127 29141 62919605
Sleep apnoea syndrome 23.58 10.32 148 540128 28985 62919761
Product dose omission issue 23.54 10.32 1696 538580 232617 62716129
Nasal polyps 23.44 10.32 11 540265 6028 62942718
Tenosynovitis 23.43 10.32 199 540077 13596 62935150
Rash maculo-papular 23.33 10.32 167 540109 31729 62917017
Purpura 23.32 10.32 38 540238 11347 62937399
Dry skin 23.28 10.32 342 539934 56545 62892201
Febrile bone marrow aplasia 23.25 10.32 17 540259 7308 62941438
Breast cancer stage I 23.18 10.32 15 540261 6874 62941872
Femur fracture 23.13 10.32 491 539785 41265 62907481
Tenosynovitis stenosans 23.04 10.32 72 540204 3292 62945454
Diabetes mellitus 23.02 10.32 335 539941 55475 62893271
Malaise 22.90 10.32 3146 537130 412808 62535938
Injection site pain 22.76 10.32 1336 538940 128464 62820282
Neck mass 22.75 10.32 75 540201 3528 62945218
Affective disorder 22.64 10.32 12 540264 6134 62942612
Synovial cyst 22.44 10.32 159 540117 10274 62938472
Multiple-drug resistance 22.36 10.32 8 540268 5162 62943584
Cardiogenic shock 22.26 10.32 78 540198 17854 62930892
Maternal exposure timing unspecified 22.19 10.32 119 540157 6968 62941778
Complication of device insertion 22.19 10.32 19 540257 7545 62941201
Red blood cell sedimentation rate 22.18 10.32 91 540185 4763 62943983
Stevens-Johnson syndrome 22.18 10.32 123 540153 24827 62923919
Retinitis 22.17 10.32 108 540168 6088 62942658
Muscle twitching 22.17 10.32 89 540187 19579 62929167
Complication of device removal 22.17 10.32 8 540268 5134 62943612
Exostosis 22.09 10.32 241 540035 17621 62931125
Sexual dysfunction 22.08 10.32 5 540271 4354 62944392
Labelled drug-drug interaction medication error 21.99 10.32 51 540225 13348 62935398
Muscle spasms 21.94 10.32 1095 539181 155055 62793691
Rotator cuff repair 21.93 10.32 53 540223 2081 62946665
Dislocation of vertebra 21.83 10.32 137 540139 8498 62940248
Acute respiratory failure 21.75 10.32 188 540088 34297 62914449
Infective pulmonary exacerbation of cystic fibrosis 21.48 10.32 26 540250 8791 62939955
Dysmorphism 21.46 10.32 55 540221 2241 62946505
Pulmonary hypertension 21.41 10.32 207 540069 36916 62911830
Clostridium difficile colitis 21.38 10.32 96 540180 20473 62928273
Glycosylated haemoglobin increased 21.32 10.32 46 540230 12352 62936394
Abdominal pain 21.29 10.32 2179 538097 291277 62657469
Wound infection 21.25 10.32 277 539999 21133 62927613
Lip dry 21.14 10.32 213 540063 15257 62933489
Arthritis infective 21.12 10.32 110 540166 6368 62942378
Skin papilloma 21.03 10.32 91 540185 4878 62943868
Developmental hip dysplasia 20.93 10.32 40 540236 1332 62947414
Anti-cyclic citrullinated peptide antibody 20.84 10.32 113 540163 6645 62942101
Genital haemorrhage 20.80 10.32 19 540257 7313 62941433
Placental disorder 20.71 10.32 42 540234 1462 62947284
Coronary artery disease 20.65 10.32 176 540100 32201 62916545
Aspergillus infection 20.65 10.32 23 540253 8070 62940676
Body temperature decreased 20.64 10.32 264 540012 20055 62928691
Urinary retention 20.57 10.32 162 540114 30139 62918607
Hypothyroidism 20.46 10.32 248 540028 42384 62906362
Malignant melanoma 20.45 10.32 166 540110 11190 62937556
Cardiotoxicity 20.43 10.32 25 540251 8413 62940333
Synovial fluid analysis 20.43 10.32 56 540220 2377 62946369
Schizoaffective disorder 20.37 10.32 3 540273 3559 62945187
Crying 20.25 10.32 116 540160 23227 62925519
Injection site rash 20.23 10.32 247 540029 18562 62930184
Lip swelling 20.20 10.32 168 540108 30895 62917851
Rash erythematous 20.14 10.32 248 540028 42262 62906484
Hallucination, auditory 20.11 10.32 50 540226 12774 62935972
Body height below normal 20.10 10.32 52 540224 2131 62946615
Prescribed overdose 20.03 10.32 405 539871 33748 62914998
Gastroenteritis viral 20.03 10.32 298 539978 23402 62925344
Bradyphrenia 19.91 10.32 18 540258 6962 62941784
Acute respiratory distress syndrome 19.86 10.32 118 540158 23416 62925330
Skin exfoliation 19.84 10.32 253 540023 42849 62905897
Cough 19.72 10.32 2185 538091 290558 62658188
Pemphigoid 19.71 10.32 20 540256 7324 62941422
Myoclonus 19.71 10.32 69 540207 15799 62932947
Swollen tongue 19.67 10.32 195 540081 34605 62914141
Acute graft versus host disease in skin 19.53 10.32 3 540273 3449 62945297
Hallucination, visual 19.50 10.32 91 540185 19207 62929539
Lethargy 19.50 10.32 347 539929 55660 62893086
Dermatitis atopic 19.41 10.32 33 540243 9691 62939055
Adjustment disorder with depressed mood 19.38 10.32 151 540125 10053 62938693
Paraesthesia oral 19.35 10.32 91 540185 19165 62929581
Hypomagnesaemia 19.34 10.32 154 540122 28583 62920163
Abdominal distension 19.32 10.32 575 539701 86040 62862706
Therapeutic response decreased 19.32 10.32 672 539604 60853 62887893
Hemiplegia 19.21 10.32 31 540245 9292 62939454
Skin ulcer 19.17 10.32 491 539785 42554 62906192
Synovial disorder 19.13 10.32 49 540227 1996 62946750
Nervousness 19.05 10.32 170 540106 30809 62917937
Loose body in joint 19.02 10.32 37 540239 1249 62947497
Pseudomonas infection 18.96 10.32 42 540234 11171 62937575
Sinus bradycardia 18.94 10.32 62 540214 14489 62934257
Cardiomyopathy 18.93 10.32 81 540195 17503 62931243
Headache 18.89 10.32 4946 535330 628295 62320451
Mental disorder 18.81 10.32 136 540140 25783 62922963
Chills 18.77 10.32 781 539495 112597 62836149
Lymphopenia 18.77 10.32 86 540190 18241 62930505
Tardive dyskinesia 18.74 10.32 27 540249 8475 62940271
Hyperprolactinaemia 18.73 10.32 5 540271 3895 62944851
Jaundice 18.66 10.32 159 540117 29092 62919654
Fear 18.63 10.32 70 540206 15696 62933050
Erythema 18.48 10.32 1267 539009 174484 62774262
Hallucinations, mixed 18.43 10.32 9 540267 4820 62943926
Leukocytosis 18.38 10.32 137 540139 25798 62922948
Pulmonary congestion 18.28 10.32 81 540195 17337 62931409
Deep vein thrombosis postoperative 18.26 10.32 162 540114 11207 62937539
Cyanosis 18.23 10.32 78 540198 16857 62931889
Hepatitis acute 18.16 10.32 31 540245 9089 62939657
Atrioventricular block 18.16 10.32 23 540253 7624 62941122
Foetal anticonvulsant syndrome 18.09 10.32 24 540252 581 62948165
Pancreatitis 18.02 10.32 301 539975 48754 62899992
Lymphoedema 18.01 10.32 46 540230 11646 62937100
Psychomotor hyperactivity 17.98 10.32 40 540236 10623 62938123
Infusion site pain 17.98 10.32 78 540198 16791 62931955
Therapy partial responder 17.95 10.32 40 540236 10618 62938128
Systemic inflammatory response syndrome 17.90 10.32 13 540263 5608 62943138
Acute chest syndrome 17.86 10.32 28 540248 793 62947953
Anhedonia 17.83 10.32 42 540234 10932 62937814
Spinal stenosis 17.83 10.32 200 540076 14725 62934021
Tubulointerstitial nephritis 17.76 10.32 98 540178 19805 62928941
Acute myocardial infarction 17.75 10.32 181 540095 31943 62916803
Memory impairment 17.73 10.32 716 539560 103542 62845204
Blood glucose decreased 17.71 10.32 105 540171 20847 62927899
Shock haemorrhagic 17.62 10.32 36 540240 9859 62938887
Clear cell renal cell carcinoma 17.59 10.32 39 540237 1446 62947300
Cardiac failure acute 17.51 10.32 34 540242 9489 62939257
Atrial septal defect 17.49 10.32 110 540166 6828 62941918
Rheumatoid lung 17.48 10.32 72 540204 3776 62944970
Circulatory collapse 17.47 10.32 112 540164 21826 62926920
Jaundice cholestatic 17.42 10.32 22 540254 7302 62941444
Vascular device infection 17.35 10.32 22 540254 7290 62941456
Incorrect product administration duration 17.35 10.32 46 540230 11500 62937246
Epstein-Barr virus infection 17.32 10.32 26 540250 8024 62940722
Antinuclear antibody positive 17.26 10.32 122 540154 7877 62940869
Transplant dysfunction 17.24 10.32 10 540266 4862 62943884
Pericardial effusion 17.17 10.32 168 540108 29890 62918856
Oliguria 17.17 10.32 32 540244 9069 62939677
Hepatitis B reactivation 17.14 10.32 3 540273 3134 62945612
Renal injury 17.10 10.32 34 540242 9405 62939341
Delirium 17.01 10.32 315 539961 50226 62898520
Ileus 17.00 10.32 66 540210 14659 62934087
Ketoacidosis 16.95 10.32 8 540268 4370 62944376
Sensitisation 16.92 10.32 4 540272 3382 62945364
Multiple drug therapy 16.90 10.32 5 540271 3641 62945105
Neutropenic colitis 16.82 10.32 3 540273 3092 62945654
Tinnitus 16.82 10.32 208 540068 35420 62913326
Hyperthyroidism 16.79 10.32 66 540210 14607 62934139
Blood potassium decreased 16.73 10.32 254 540022 41772 62906974
Muscular weakness 16.61 10.32 861 539415 121492 62827254
Complication associated with device 16.61 10.32 81 540195 16897 62931849
Colitis microscopic 16.61 10.32 34 540242 9305 62939441
Paranoia 16.45 10.32 48 540228 11631 62937115
Scleritis 16.43 10.32 78 540198 4350 62944396
Dysuria 16.29 10.32 196 540080 33542 62915204
Eating disorder 16.23 10.32 95 540181 18921 62929825
Bradypnoea 16.22 10.32 5 540271 3545 62945201
Haematoma 16.17 10.32 204 540072 34616 62914130
Polyuria 16.14 10.32 30 540246 8512 62940234
Congenital arterial malformation 16.12 10.32 17 540259 320 62948426
Eosinophil count increased 16.07 10.32 44 540232 10884 62937862
Bursitis 16.06 10.32 421 539855 36620 62912126
Product administered to patient of inappropriate age 16.05 10.32 4 540272 3264 62945482
Human antichimeric antibody positive 15.96 10.32 41 540235 1673 62947073
Mucosal inflammation 15.94 10.32 292 539984 46636 62902110
Polyhydramnios 15.92 10.32 49 540227 2222 62946524
Antibody test positive 15.90 10.32 55 540221 2652 62946094
Product preparation error 15.89 10.32 17 540259 6075 62942671
Graft versus host disease in gastrointestinal tract 15.86 10.32 4 540272 3237 62945509
Immune reconstitution inflammatory syndrome 15.84 10.32 17 540259 6067 62942679
Urinary incontinence 15.84 10.32 185 540091 31829 62916917
Sleep disorder due to a general medical condition 15.82 10.32 52 540224 12136 62936610
Renal disorder 15.76 10.32 192 540084 32782 62915964
Generalised oedema 15.75 10.32 75 540201 15743 62933003
Pulmonary tuberculosis 15.64 10.32 78 540198 4439 62944307
Myocarditis 15.62 10.32 41 540235 10284 62938462
Cytomegalovirus viraemia 15.60 10.32 15 540261 5634 62943112
Affect lability 15.59 10.32 46 540230 11105 62937641
Skin cancer 15.58 10.32 158 540118 11337 62937409
Proctitis 15.56 10.32 14 540262 5427 62943319
Cyst 15.53 10.32 186 540090 13913 62934833
Acute coronary syndrome 15.47 10.32 40 540236 10086 62938660
Klebsiella infection 15.39 10.32 31 540245 8535 62940211
Salivary hypersecretion 15.32 10.32 26 540250 7640 62941106
Acidosis 15.23 10.32 47 540229 11186 62937560
Hyperuricaemia 15.14 10.32 14 540262 5356 62943390
Right ventricular failure 15.13 10.32 85 540191 17103 62931643
Respiratory acidosis 15.12 10.32 21 540255 6694 62942052
Body temperature increased 15.08 10.32 224 540052 36968 62911778
Cholecystitis chronic 15.03 10.32 42 540234 10319 62938427
Bundle branch block left 14.99 10.32 23 540253 7036 62941710
Product prescribing error 14.99 10.32 147 540129 26142 62922604
Hyperlactacidaemia 14.98 10.32 3 540273 2846 62945900
Muscle rigidity 14.97 10.32 49 540227 11451 62937295
Fracture delayed union 14.92 10.32 50 540226 2372 62946374
Product adhesion issue 14.91 10.32 11 540265 4708 62944038
Breast cancer female 14.88 10.32 62 540214 13497 62935249
Ear infection 14.78 10.32 428 539848 37785 62910961
Multiple allergies 14.60 10.32 64 540212 13738 62935008
Stillbirth 14.59 10.32 103 540173 6647 62942099
Atrial tachycardia 14.59 10.32 9 540267 4231 62944515
Pulseless electrical activity 14.58 10.32 26 540250 7495 62941251
Carotid artery thrombosis 14.57 10.32 3 540273 2791 62945955
Rectal haemorrhage 14.56 10.32 312 539964 48718 62900028
Hypertransaminasaemia 14.56 10.32 21 540255 6588 62942158
Personality change 14.54 10.32 23 540253 6950 62941796
Lupus vulgaris 14.47 10.32 94 540182 5900 62942846
Tendonitis 14.44 10.32 241 540035 19374 62929372
Injection site warmth 14.42 10.32 195 540081 15000 62933746
Middle insomnia 14.38 10.32 57 540219 12586 62936160
Paraesthesia 14.35 10.32 1145 539131 155821 62792925
Myopathy 14.35 10.32 48 540228 11143 62937603
Starvation ketoacidosis 14.32 10.32 9 540267 77 62948669
Laryngospasm 14.32 10.32 4 540272 3024 62945722
Aspiration 14.29 10.32 46 540230 10805 62937941
Peripheral sensory neuropathy 14.23 10.32 26 540250 7425 62941321
Subdural haematoma 14.22 10.32 68 540208 14260 62934486
Cushingoid 14.20 10.32 122 540154 8363 62940383
Breast feeding 14.17 10.32 26 540250 839 62947907
Fear of injection 14.16 10.32 107 540169 7057 62941689
Device dislocation 14.13 10.32 145 540131 25560 62923186
Hepatitis cholestatic 14.05 10.32 23 540253 6855 62941891
Blood parathyroid hormone decreased 13.96 10.32 136 540140 9655 62939091
Fall 13.95 10.32 3039 537237 389295 62559451
Electrocardiogram QRS complex prolonged 13.95 10.32 18 540258 5920 62942826
Food allergy 13.88 10.32 50 540226 11351 62937395
Injury 13.82 10.32 759 539517 72488 62876258
Device breakage 13.80 10.32 51 540225 11491 62937255
Postoperative wound infection 13.78 10.32 148 540128 10777 62937969
Delusion 13.78 10.32 54 540222 11963 62936783
Hypervolaemia 13.74 10.32 165 540111 28248 62920498
Bone lesion 13.64 10.32 18 540258 5863 62942883
Skin toxicity 13.63 10.32 12 540264 4702 62944044
Colorectal cancer 13.60 10.32 7 540269 3638 62945108
Presyncope 13.58 10.32 161 540115 27624 62921122
Reversible cerebral vasoconstriction syndrome 13.56 10.32 3 540273 2655 62946091
Respiration abnormal 13.54 10.32 21 540255 6396 62942350
Exomphalos 13.53 10.32 20 540256 537 62948209
Visual impairment 13.50 10.32 584 539692 83862 62864884
Oedema peripheral 13.48 10.32 1409 538867 188102 62760644
Hypophagia 13.47 10.32 186 540090 31073 62917673
Pathogen resistance 13.44 10.32 21 540255 6377 62942369
Granuloma skin 13.44 10.32 120 540156 8317 62940429
Metastases to lymph nodes 13.43 10.32 31 540245 8127 62940619
Dermatitis exfoliative 13.40 10.32 16 540260 5443 62943303
Hyperthermia 13.36 10.32 37 540239 9119 62939627
Pulmonary alveolar haemorrhage 13.36 10.32 12 540264 4656 62944090
Coordination abnormal 13.31 10.32 66 540210 13707 62935039
Head injury 13.29 10.32 159 540117 27237 62921509
Abortion incomplete 13.28 10.32 5 540271 3126 62945620
Illness 13.21 10.32 317 539959 48742 62900004
Speech disorder developmental 13.17 10.32 22 540254 658 62948088
Amylase increased 13.16 10.32 21 540255 6324 62942422
Fracture 13.12 10.32 237 540039 19347 62929399
Adenovirus infection 13.11 10.32 7 540269 3564 62945182
Crohn's disease 13.08 10.32 79 540197 4834 62943912
Chronic graft versus host disease 13.08 10.32 5 540271 3097 62945649
Product substitution issue 13.08 10.32 81 540195 15915 62932831
Treatment noncompliance 13.07 10.32 231 540045 37094 62911652
Gastroschisis 12.99 10.32 17 540259 406 62948340
Dementia 12.98 10.32 100 540176 18694 62930052
Bundle branch block right 12.98 10.32 14 540262 4984 62943762
Hypoglycaemic coma 12.95 10.32 3 540273 2572 62946174
Short stature 12.93 10.32 22 540254 668 62948078
Mood altered 12.93 10.32 73 540203 14670 62934076
Subarachnoid haemorrhage 12.92 10.32 70 540206 14213 62934533
Pulmonary haemorrhage 12.89 10.32 26 540250 7155 62941591
Hypercholesterolaemia 12.85 10.32 254 540022 21080 62927666
Blood urea increased 12.83 10.32 153 540123 26226 62922520
Autism spectrum disorder 12.83 10.32 25 540251 845 62947901
Pallor 12.77 10.32 183 540093 30385 62918361
Nasal obstruction 12.74 10.32 38 540238 1693 62947053
Nephropathy toxic 12.61 10.32 40 540236 9439 62939307
HIV-associated neurocognitive disorder 12.59 10.32 10 540266 128 62948618
Feeling hot 12.58 10.32 329 539947 50025 62898721
Toxic encephalopathy 12.53 10.32 23 540253 6556 62942190
Rebound effect 12.52 10.32 12 540264 4514 62944232
Tumour marker increased 12.50 10.32 14 540262 4901 62943845
Premature delivery 12.50 10.32 342 539934 29939 62918807
Maternal exposure during breast feeding 12.47 10.32 70 540206 4171 62944575
Visual acuity reduced 12.46 10.32 122 540154 21704 62927042
Blood lactic acid increased 12.43 10.32 26 540250 7060 62941686
Pregnancy with contraceptive device 12.35 10.32 13 540263 4681 62944065
Epistaxis 12.24 10.32 500 539776 72225 62876521
Lymph gland infection 12.22 10.32 18 540258 482 62948264
Onychomycosis 12.22 10.32 112 540164 7820 62940926
Cholestasis of pregnancy 12.14 10.32 30 540246 1195 62947551
Intracranial pressure increased 12.12 10.32 16 540260 5211 62943535
Hepatic cytolysis 12.09 10.32 79 540197 15328 62933418
Haemorrhage in pregnancy 12.09 10.32 40 540236 1885 62946861
Progressive multifocal leukoencephalopathy 12.05 10.32 63 540213 12908 62935838
Body mass index decreased 12.05 10.32 17 540259 437 62948309
Renal tubular necrosis 12.01 10.32 56 540220 11822 62936924
Transaminases increased 12.00 10.32 191 540085 31176 62917570
Inadequate analgesia 11.99 10.32 5 540271 2938 62945808
Ulcer 11.98 10.32 299 539977 25808 62922938
Joint noise 11.94 10.32 71 540205 4321 62944425
Joint lock 11.92 10.32 45 540231 2266 62946480
Dermatitis acneiform 11.89 10.32 15 540261 4981 62943765
Sleep terror 11.84 10.32 4 540272 2676 62946070
Sciatica 11.82 10.32 379 539897 33945 62914801
Product physical issue 11.80 10.32 15 540261 4965 62943781
Congenital cerebral cyst 11.79 10.32 13 540263 258 62948488
Oligoarthritis 11.77 10.32 19 540257 552 62948194
Disturbance in social behaviour 11.75 10.32 10 540266 3983 62944763
Learning disorder 11.74 10.32 21 540255 664 62948082
Ejection fraction 11.71 10.32 3 540273 2403 62946343
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.69 10.32 5 540271 2894 62945852
Ankle arthroplasty 11.68 10.32 38 540238 1775 62946971
Contrast media allergy 11.68 10.32 3 540273 2398 62946348
Polydipsia 11.67 10.32 8 540268 3556 62945190
Cardiac disorder 11.66 10.32 336 539940 50480 62898266
Blood lactate dehydrogenase increased 11.66 10.32 133 540143 22983 62925763
Pruritus genital 11.66 10.32 4 540272 2650 62946096
Hypertelorism 11.66 10.32 17 540259 451 62948295
Multiple sclerosis 11.61 10.32 142 540134 24230 62924516
Hypoventilation 11.60 10.32 14 540262 4740 62944006
Gestational hypertension 11.59 10.32 46 540230 2371 62946375
Pneumonia viral 11.57 10.32 32 540244 7890 62940856
Ileus paralytic 11.54 10.32 13 540263 4538 62944208
Talipes 11.52 10.32 34 540242 1506 62947240
Catheter site pain 11.49 10.32 14 540262 4721 62944025
Blood iron increased 11.49 10.32 34 540242 1508 62947238
Intervertebral disc degeneration 11.47 10.32 193 540083 15539 62933207
Diabetes insipidus 11.46 10.32 4 540272 2621 62946125
Foetal distress syndrome 11.44 10.32 31 540245 1307 62947439
Squamous cell carcinoma 11.39 10.32 118 540158 8514 62940232
Haemodynamic instability 11.39 10.32 40 540236 9150 62939596
Hot flush 11.31 10.32 340 539936 50819 62897927
Induced labour 11.29 10.32 25 540251 926 62947820
Wrong product administered 11.23 10.32 22 540254 6119 62942627
Bacteraemia 11.20 10.32 94 540182 17254 62931492
Dactylitis 11.18 10.32 48 540228 2564 62946182
Toxic epidermal necrolysis 11.18 10.32 150 540126 25184 62923562
Panniculitis 11.17 10.32 147 540129 11238 62937508
Device issue 11.16 10.32 139 540137 23642 62925104
Skin plaque 11.14 10.32 35 540241 8285 62940461
Myocardial ischaemia 11.10 10.32 64 540212 12795 62935951
Plasma cell myeloma 11.10 10.32 227 540049 35678 62913068
Catheter site erythema 11.08 10.32 12 540264 4264 62944482
Ingrown hair 11.05 10.32 19 540257 582 62948164
Hepatitis fulminant 11.05 10.32 8 540268 3456 62945290
Nail injury 11.04 10.32 20 540256 639 62948107
Uterine perforation 11.03 10.32 27 540249 6936 62941810
Cyst rupture 11.00 10.32 20 540256 641 62948105
Human anti-human antibody test 10.98 10.32 16 540260 424 62948322
Tongue disorder 10.97 10.32 138 540138 10442 62938304
Alcoholic liver disease 10.97 10.32 9 540267 121 62948625
Serum ferritin increased 10.94 10.32 90 540186 6092 62942654
Immunosuppression 10.93 10.32 119 540157 8695 62940051
Hypernatraemia 10.92 10.32 31 540245 7578 62941168
Lymphatic fistula 10.88 10.32 22 540254 764 62947982
Bronchial secretion retention 10.84 10.32 5 540271 2768 62945978
Terminal state 10.82 10.32 3 540273 2279 62946467
Injection site haematoma 10.79 10.32 97 540179 6735 62942011
Drug screen positive 10.79 10.32 9 540267 3620 62945126
Immune effector cell-associated neurotoxicity syndrome 10.78 10.32 3 540273 2274 62946472
Anger 10.75 10.32 62 540214 12394 62936352
Neutrophilia 10.73 10.32 13 540263 4393 62944353
Haematemesis 10.72 10.32 188 540088 30224 62918522
Hereditary angioedema 10.71 10.32 31 540245 7531 62941215
Infusion site erythema 10.70 10.32 57 540219 11622 62937124
Cervical incompetence 10.69 10.32 19 540257 598 62948148
Epilepsy 10.63 10.32 164 540112 26901 62921845
Oropharyngeal pain 10.60 10.32 938 539338 93549 62855197
Atrial flutter 10.53 10.32 45 540231 9727 62939019
Infusion site swelling 10.52 10.32 45 540231 9725 62939021
Glomerular filtration rate decreased 10.51 10.32 69 540207 13372 62935374
Product residue present 10.49 10.32 11 540265 3968 62944778
Acute pulmonary oedema 10.45 10.32 35 540241 8123 62940623
International normalised ratio fluctuation 10.44 10.32 4 540272 2474 62946272
Drug effective for unapproved indication 10.43 10.32 8 540268 3356 62945390
Forceps delivery 10.35 10.32 11 540265 209 62948537
Post-traumatic stress disorder 10.32 10.32 18 540258 5233 62943513

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 507.39 10.27 832 196495 37406 34722198
Drug abuse 379.79 10.27 54 197273 99042 34660562
Completed suicide 302.93 10.27 89 197238 98079 34661525
Toxicity to various agents 264.70 10.27 453 196874 199909 34559695
Foetal exposure during pregnancy 240.34 10.27 609 196718 37492 34722112
Arthralgia 214.87 10.27 1668 195659 168373 34591231
Psoriatic arthropathy 180.11 10.27 366 196961 19432 34740172
Drug interaction 145.68 10.27 718 196609 225228 34534376
Sickle cell anaemia with crisis 132.91 10.27 138 197189 3915 34755689
Joint swelling 124.60 10.27 667 196660 59223 34700381
Dysmorphism 121.05 10.27 117 197210 3039 34756565
Psoriasis 111.83 10.27 475 196852 38337 34721267
Musculoskeletal stiffness 96.47 10.27 519 196808 46161 34713443
Intentional overdose 88.48 10.27 70 197257 43604 34716000
Product use in unapproved indication 85.99 10.27 356 196971 117143 34642461
Premature baby 79.54 10.27 268 197059 19365 34740239
Enthesopathy 76.00 10.27 111 197216 4502 34755102
Blood pressure fluctuation 75.83 10.27 313 197014 24936 34734668
Death 74.64 10.27 1696 195631 396353 34363251
Acute kidney injury 72.03 10.27 1250 196077 303738 34455866
Tenosynovitis 71.03 10.27 107 197220 4463 34755141
Synovitis 70.79 10.27 207 197120 13859 34745745
Exposure during pregnancy 69.50 10.27 155 197172 8779 34750825
Pain 69.12 10.27 1576 195751 203099 34556505
Hepatic function abnormal 68.39 10.27 90 197237 44273 34715331
Speech disorder developmental 66.97 10.27 72 197255 2128 34757476
C-reactive protein abnormal 62.10 10.27 146 197181 8564 34751040
Febrile neutropenia 60.56 10.27 488 196839 136361 34623243
Arthropathy 60.29 10.27 306 197021 26601 34733003
Foetal anticonvulsant syndrome 57.20 10.27 50 197277 1137 34758467
Drug resistance 57.14 10.27 38 197289 25889 34733715
Drug dependence 55.42 10.27 34 197293 24183 34735421
Neonatal respiratory distress syndrome 55.10 10.27 89 197238 3945 34755659
Blood pressure systolic increased 54.95 10.27 266 197061 22686 34736918
Suicide attempt 54.71 10.27 85 197242 39031 34720573
Maternal exposure during pregnancy 54.65 10.27 99 197228 4819 34754785
Intentional product misuse 53.98 10.27 110 197217 45501 34714103
Rhabdomyolysis 53.34 10.27 201 197126 67962 34691642
Sopor 53.15 10.27 4 197323 12132 34747472
Alanine aminotransferase abnormal 52.90 10.27 95 197232 4593 34755011
Overdose 52.59 10.27 300 197027 90759 34668845
Coma 51.68 10.27 113 197214 45565 34714039
Hypospadias 51.25 10.27 76 197251 3125 34756479
Multiple organ dysfunction syndrome 51.12 10.27 240 197087 76326 34683278
Disease progression 50.79 10.27 379 196948 107698 34651906
Atrial septal defect 49.57 10.27 121 197206 7271 34752333
Arthritis 47.79 10.27 322 197005 31024 34728580
Nasopharyngitis 46.80 10.27 602 196725 69366 34690238
Learning disorder 46.73 10.27 43 197284 1048 34758556
Autism spectrum disorder 46.45 10.27 61 197266 2235 34757369
Cardiac failure 46.27 10.27 313 197014 90935 34668669
Cryptorchism 45.66 10.27 57 197270 1984 34757620
Maternal drugs affecting foetus 45.57 10.27 81 197246 3884 34755720
Low birth weight baby 45.34 10.27 122 197205 7783 34751821
Off label use 45.25 10.27 1923 195404 417601 34342003
Peripheral swelling 44.82 10.27 643 196684 75898 34683706
Hypoglycaemia neonatal 43.99 10.27 54 197273 1847 34757757
Cytomegalovirus infection 43.45 10.27 50 197277 26085 34733519
Lower respiratory tract infection 42.40 10.27 315 197012 31322 34728282
Small for dates baby 41.05 10.27 77 197250 3850 34755754
Blood pressure systolic abnormal 40.76 10.27 77 197250 3871 34755733
Rheumatoid nodule 40.23 10.27 65 197262 2882 34756722
Ventricular septal defect 40.03 10.27 77 197250 3924 34755680
Tongue disorder 39.71 10.27 91 197236 5248 34754356
Poisoning 39.71 10.27 10 197317 12216 34747388
Maternal exposure during breast feeding 39.31 10.27 46 197281 1495 34758109
Syndactyly 38.37 10.27 35 197292 843 34758761
Haemoglobin decreased 38.24 10.27 922 196405 119850 34639754
Drug reaction with eosinophilia and systemic symptoms 36.25 10.27 83 197244 32929 34726675
Osteoarthritis 35.74 10.27 219 197108 20423 34739181
Immune reconstitution inflammatory syndrome 35.39 10.27 4 197323 8755 34750849
Pain in extremity 34.82 10.27 948 196379 125565 34634039
Joint effusion 34.81 10.27 85 197242 5108 34754496
Renal failure 34.72 10.27 523 196804 130034 34629570
Blood pressure diastolic abnormal 34.60 10.27 81 197246 4737 34754867
Respiratory arrest 34.58 10.27 66 197261 27977 34731627
Appendicolith 34.57 10.27 4 197323 8597 34751007
Hand deformity 34.03 10.27 69 197258 3656 34755948
Developmental delay 33.59 10.27 58 197269 2717 34756887
Heart rate decreased 33.31 10.27 299 197028 31446 34728158
Blood pressure diastolic decreased 33.24 10.27 120 197207 8974 34750630
Poisoning deliberate 33.21 10.27 3 197324 7841 34751763
Renal impairment 33.17 10.27 357 196970 94156 34665448
Somnolence 32.76 10.27 436 196891 110680 34648924
Pathogen resistance 32.29 10.27 7 197320 9475 34750129
Foot deformity 32.28 10.27 76 197251 4461 34755143
Tendonitis 32.06 10.27 119 197208 9021 34750583
Joint laxity 32.03 10.27 23 197304 389 34759215
Grip strength decreased 31.72 10.27 61 197266 3108 34756496
C-reactive protein increased 31.47 10.27 454 196873 53644 34705960
Talipes 31.28 10.27 46 197281 1877 34757727
Weight decreased 31.23 10.27 1254 196073 175047 34584557
Exposure via breast milk 31.15 10.27 47 197280 1963 34757641
Basal cell carcinoma 29.99 10.27 202 197125 19456 34740148
Blood pressure increased 28.90 10.27 676 196651 87426 34672178
Bradycardia 28.88 10.27 279 197048 75139 34684465
Drug withdrawal syndrome 28.79 10.27 42 197285 19792 34739812
Congenital hand malformation 28.54 10.27 25 197302 570 34759034
Plagiocephaly 28.27 10.27 24 197303 524 34759080
Depressed level of consciousness 28.16 10.27 135 197192 42706 34716898
Altered state of consciousness 28.12 10.27 54 197273 22839 34736765
Acute hepatic failure 27.94 10.27 23 197304 14051 34745553
Knee arthroplasty 27.87 10.27 99 197228 7345 34752259
Hypermobility syndrome 27.52 10.27 20 197307 345 34759259
Pulmonary fibrosis 27.45 10.27 188 197139 18208 34741396
Infusion related reaction 26.90 10.27 435 196892 52622 34706982
Fall 26.81 10.27 1401 195926 201484 34558120
Drug intolerance 26.79 10.27 479 196848 59091 34700513
Suicidal ideation 26.70 10.27 127 197200 40261 34719343
Dysgraphia 26.64 10.27 47 197280 2240 34757364
Shock 26.38 10.27 61 197266 24118 34735486
Red blood cell sedimentation rate increased 26.27 10.27 112 197215 9050 34750554
Intellectual disability 26.23 10.27 35 197292 1303 34758301
Jaundice neonatal 26.06 10.27 35 197292 1311 34758293
Colitis ulcerative 25.95 10.27 171 197156 16349 34743255
Palmar-plantar erythrodysaesthesia syndrome 25.95 10.27 34 197293 16761 34742843
Caesarean section 25.90 10.27 45 197282 2119 34757485
Finger deformity 25.79 10.27 37 197290 1476 34758128
Body temperature decreased 25.62 10.27 143 197184 12891 34746713
Substance abuse 25.30 10.27 6 197321 7635 34751969
Musculoskeletal pain 25.29 10.27 284 197043 31679 34727925
Astigmatism 25.13 10.27 31 197296 1066 34758538
Acute chest syndrome 25.06 10.27 27 197300 800 34758804
Venoocclusive liver disease 24.95 10.27 7 197320 7959 34751645
Psychotic disorder 24.85 10.27 64 197263 24388 34735216
Pancytopenia 24.75 10.27 708 196619 94449 34665155
Malignant neoplasm progression 24.68 10.27 349 196978 87697 34671907
Language disorder 24.54 10.27 45 197282 2211 34757393
Hypoglycaemia 24.52 10.27 194 197133 54446 34705158
Diaphragmatic disorder 24.45 10.27 33 197294 1242 34758362
Angioedema 24.43 10.27 118 197209 37256 34722348
Large for dates baby 24.42 10.27 28 197299 890 34758714
Foetal growth restriction 24.08 10.27 64 197263 4053 34755551
Wound 24.05 10.27 155 197172 14709 34744895
Polyarthritis 23.99 10.27 68 197259 4472 34755132
Anal fistula 23.93 10.27 76 197251 5323 34754281
Rash maculo-papular 23.50 10.27 82 197245 28369 34731235
Hyperglycaemia 23.35 10.27 129 197198 39351 34720253
Mobility decreased 23.07 10.27 266 197061 29862 34729742
Cardiogenic shock 22.47 10.27 76 197251 26542 34733062
Tuberculosis 22.43 10.27 102 197225 8475 34751129
Hydrops foetalis 22.32 10.27 26 197301 841 34758763
Wrong technique in product usage process 22.16 10.27 116 197211 35870 34723734
Ultrasound antenatal screen 22.06 10.27 21 197306 535 34759069
No adverse event 21.80 10.27 62 197265 22865 34736739
Inflammation 21.75 10.27 250 197077 28045 34731559
Cardiac arrest 21.67 10.27 397 196930 95762 34663842
Hypotonia neonatal 21.63 10.27 32 197295 1313 34758291
Blood pressure diastolic increased 21.60 10.27 70 197257 4955 34754649
Neck pain 21.33 10.27 228 197099 25121 34734483
Selective eating disorder 21.31 10.27 37 197290 1741 34757863
Ventricular fibrillation 21.15 10.27 63 197264 22891 34736713
Hyperbilirubinaemia neonatal 21.05 10.27 24 197303 758 34758846
Aspergillus infection 20.85 10.27 23 197304 12231 34747373
Neurotoxicity 20.82 10.27 44 197283 17966 34741638
Sedation 20.58 10.27 56 197271 20950 34738654
Motor developmental delay 20.57 10.27 22 197305 646 34758958
Knee deformity 20.57 10.27 22 197305 646 34758958
Ankylosing spondylitis 20.53 10.27 74 197253 5530 34754074
Pyrexia 20.39 10.27 1611 195716 331402 34428202
Fatigue 20.34 10.27 2389 194938 368264 34391340
Otitis media 20.32 10.27 48 197279 2824 34756780
Dyspraxia 20.24 10.27 18 197309 419 34759185
Haematocrit decreased 20.19 10.27 274 197053 31942 34727662
Encephalitis toxic 19.96 10.27 15 197312 273 34759331
Vitamin D deficiency 19.90 10.27 82 197245 6526 34753078
Serum ferritin increased 19.89 10.27 78 197249 6068 34753536
Joint stiffness 19.87 10.27 117 197210 10756 34748848
Radiation inflammation 19.81 10.27 25 197302 880 34758724
Trisomy 18 19.64 10.27 23 197304 748 34758856
Sleep disorder due to a general medical condition 19.62 10.27 3 197324 5218 34754386
Skin cancer 19.59 10.27 112 197215 10185 34749419
Aptyalism 19.58 10.27 17 197310 383 34759221
Lactic acidosis 19.29 10.27 116 197211 34656 34724948
Ear infection 19.28 10.27 111 197216 10120 34749484
Nasal disorder 19.16 10.27 37 197290 1891 34757713
Incorrect route of product administration 19.14 10.27 34 197293 14811 34744793
Drug withdrawal syndrome neonatal 18.92 10.27 54 197273 3565 34756039
Osteonecrosis of jaw 18.82 10.27 46 197281 17843 34741761
Ear disorder 18.75 10.27 34 197293 1656 34757948
Disseminated intravascular coagulation 18.61 10.27 62 197265 21754 34737850
Neck mass 18.60 10.27 33 197294 1580 34758024
Post procedural infection 18.54 10.27 65 197262 4791 34754813
Drug ineffective for unapproved indication 18.49 10.27 70 197257 23645 34735959
Foetal disorder 18.37 10.27 23 197304 803 34758801
Hydrocele 18.29 10.27 38 197289 2049 34757555
Second primary malignancy 18.14 10.27 11 197316 7875 34751729
Congenital foot malformation 18.12 10.27 17 197310 425 34759179
Cleft lip and palate 18.10 10.27 24 197303 888 34758716
Back disorder 18.07 10.27 80 197247 6571 34753033
Dyslexia 18.00 10.27 15 197312 319 34759285
Cleft lip 17.88 10.27 15 197312 322 34759282
Arthritis infective 17.86 10.27 51 197276 3368 34756236
Vomiting 17.71 10.27 1182 196145 246439 34513165
Joint range of motion decreased 17.68 10.27 85 197242 7227 34752377
Limb reduction defect 17.64 10.27 14 197313 277 34759327
Oropharyngeal pain 17.64 10.27 290 197037 35195 34724409
Agranulocytosis 17.50 10.27 72 197255 23749 34735855
Serotonin syndrome 17.45 10.27 56 197271 19877 34739727
Malignant melanoma 17.42 10.27 91 197236 7999 34751605
Umbilical hernia 17.34 10.27 62 197265 4615 34754989
Red blood cell sedimentation rate 17.31 10.27 27 197300 1161 34758443
Suspected suicide 17.23 10.27 3 197324 4745 34754859
Respiratory disorder neonatal 17.09 10.27 32 197295 1598 34758006
Poor venous access 16.95 10.27 66 197261 5117 34754487
Strabismus 16.94 10.27 33 197294 1698 34757906
Respiratory failure 16.87 10.27 475 196852 108097 34651507
Haematochezia 16.80 10.27 362 196965 46172 34713432
Crohn's disease 16.78 10.27 47 197280 3070 34756534
Blood parathyroid hormone decreased 16.71 10.27 30 197297 1450 34758154
Arthritis bacterial 16.69 10.27 65 197262 5041 34754563
Acute graft versus host disease 16.52 10.27 8 197319 6495 34753109
Decreased gait velocity 16.50 10.27 11 197316 164 34759440
Medical device implantation 16.49 10.27 19 197308 607 34758997
Infection 16.38 10.27 648 196679 90267 34669337
Multiple congenital abnormalities 16.37 10.27 18 197309 546 34759058
Kidney infection 16.29 10.27 67 197260 5327 34754277
Influenza 16.25 10.27 381 196946 49285 34710319
Therapeutic product effect decreased 16.19 10.27 281 197046 34462 34725142
Localised infection 16.13 10.27 161 197166 17426 34742178
Agitation neonatal 16.10 10.27 25 197302 1071 34758533
Cellulitis 16.06 10.27 402 196925 52549 34707055
Anal fissure 16.01 10.27 57 197270 4233 34755371
Cystitis haemorrhagic 16.00 10.27 6 197321 5673 34753931
Juvenile idiopathic arthritis 15.99 10.27 34 197293 1863 34757741
Anaphylactic shock 15.99 10.27 42 197285 15899 34743705
Cholestasis 15.96 10.27 88 197239 26860 34732744
Gastrointestinal infection 15.95 10.27 70 197257 5728 34753876
Hypertelorism 15.90 10.27 18 197309 564 34759040
Lacrimal disorder 15.88 10.27 14 197313 322 34759282
Congenital bladder anomaly 15.85 10.27 13 197314 270 34759334
Granuloma skin 15.83 10.27 27 197300 1252 34758352
Weight decrease neonatal 15.78 10.27 14 197313 325 34759279
Sexual dysfunction 15.64 10.27 8 197319 6295 34753309
Appendicitis 15.64 10.27 38 197289 14769 34744835
Withdrawal syndrome 15.63 10.27 29 197298 12426 34747178
Intentional self-injury 15.62 10.27 34 197293 13737 34745867
Immunodeficiency 15.60 10.27 67 197260 5431 34754173
Spinal disorder 15.45 10.27 56 197271 4196 34755408
Pectus excavatum 15.44 10.27 12 197315 230 34759374
Congenital anomaly 15.42 10.27 28 197299 1365 34758239
Lung neoplasm malignant 15.36 10.27 158 197169 17237 34742367
Hypertriglyceridaemia 15.34 10.27 15 197312 8433 34751171
Skin injury 15.31 10.27 38 197289 2307 34757297
Ankyloglossia congenital 15.30 10.27 13 197314 284 34759320
Respiratory rate increased 15.29 10.27 102 197225 9792 34749812
Neuroleptic malignant syndrome 15.28 10.27 51 197276 17883 34741721
Proteinuria 15.21 10.27 54 197273 18588 34741016
Akathisia 15.19 10.27 14 197313 8095 34751509
Attention deficit hyperactivity disorder 15.19 10.27 40 197287 2519 34757085
Joint injury 15.05 10.27 96 197231 9077 34750527
Mastication disorder 15.02 10.27 27 197300 1306 34758298
Renal aplasia 14.96 10.27 20 197307 746 34758858
Acute generalised exanthematous pustulosis 14.84 10.27 10 197317 6766 34752838
Erythrosis 14.69 10.27 9 197318 115 34759489
Vitamin B12 deficiency 14.57 10.27 53 197274 3978 34755626
Ventricular tachycardia 14.57 10.27 89 197238 26490 34733114
Failure to anastomose 14.46 10.27 11 197316 204 34759400
Sarcopenia 14.35 10.27 15 197312 429 34759175
Cerebral haemorrhage 14.33 10.27 127 197200 34810 34724794
Therapy partial responder 14.32 10.27 20 197307 9596 34750008
Synovial cyst 14.28 10.27 37 197290 2307 34757297
Cardiotoxicity 14.27 10.27 7 197320 5641 34753963
Cerebral haemorrhage neonatal 14.25 10.27 12 197315 259 34759345
Joint ankylosis 14.22 10.27 29 197298 1543 34758061
Abdominal discomfort 14.14 10.27 440 196887 59395 34700209
Neutropenia 14.12 10.27 732 196595 156046 34603558
Haemangioma congenital 14.12 10.27 16 197311 502 34759102
Adenovirus infection 14.09 10.27 6 197321 5251 34754353
Microcephaly 14.07 10.27 20 197307 791 34758813
Behaviour disorder 14.06 10.27 60 197267 4850 34754754
Sinusitis 13.97 10.27 319 197008 41083 34718521
Hepatic failure 13.96 10.27 126 197201 34405 34725199
Stevens-Johnson syndrome 13.90 10.27 56 197271 18583 34741021
Urticaria 13.90 10.27 258 197069 62119 34697485
Transplant rejection 13.85 10.27 23 197304 10288 34749316
Arthrodesis 13.85 10.27 15 197312 447 34759157
Hyperthermia 13.84 10.27 24 197303 10553 34749051
Abortion spontaneous 13.80 10.27 14 197313 386 34759218
Aggression 13.73 10.27 147 197180 38817 34720787
Drug ineffective 13.67 10.27 2319 195008 454432 34305172
C-reactive protein decreased 13.67 10.27 33 197294 1969 34757635
Oesophageal fibrosis 13.59 10.27 10 197317 176 34759428
Posterior reversible encephalopathy syndrome 13.56 10.27 22 197305 9932 34749672
Upper respiratory tract infection 13.53 10.27 262 197065 32797 34726807
Product quality issue 13.47 10.27 50 197277 16985 34742619
Hernia pain 13.44 10.27 12 197315 281 34759323
Chronic graft versus host disease 13.41 10.27 4 197323 4369 34755235
Latent tuberculosis 13.35 10.27 26 197301 1337 34758267
Tooth malformation 13.35 10.27 10 197317 181 34759423
Arnold-Chiari malformation 13.34 10.27 13 197314 341 34759263
Anti-cyclic citrullinated peptide antibody positive 13.25 10.27 31 197296 1812 34757792
Agitation 13.23 10.27 236 197091 57163 34702441
BK virus infection 13.20 10.27 8 197319 5730 34753874
Tachycardia 13.13 10.27 371 196956 84401 34675203
Thrombotic microangiopathy 13.12 10.27 25 197302 10605 34748999
Scoliosis 13.01 10.27 40 197287 2753 34756851
Fistula discharge 12.98 10.27 20 197307 851 34758753
Back pain 12.97 10.27 825 196502 120964 34638640
Bronchopulmonary aspergillosis 12.96 10.27 41 197286 14618 34744986
Progressive multifocal leukoencephalopathy 12.91 10.27 22 197305 9742 34749862
Developmental coordination disorder 12.90 10.27 10 197317 191 34759413
Patent ductus arteriosus 12.89 10.27 45 197282 3309 34756295
Dysstasia 12.86 10.27 115 197212 12080 34747524
Cardio-respiratory arrest 12.82 10.27 227 197100 55046 34704558
Autoscopy 12.74 10.27 11 197316 246 34759358
Blood test abnormal 12.73 10.27 75 197252 6896 34752708
Bone cyst 12.71 10.27 28 197299 1572 34758032
Injection site pain 12.69 10.27 299 197028 38706 34720898
Hypertransaminasaemia 12.65 10.27 8 197319 5598 34754006
Respiratory depression 12.63 10.27 48 197279 16197 34743407
End stage renal disease 12.63 10.27 19 197308 8842 34750762
Abdominal adhesions 12.62 10.27 27 197300 1486 34758118
Bradycardia neonatal 12.61 10.27 21 197306 955 34758649
Loss of personal independence in daily activities 12.59 10.27 260 197067 32919 34726685
Asphyxia 12.57 10.27 12 197315 6823 34752781
Septic arthritis staphylococcal 12.50 10.27 15 197312 501 34759103
Maternal exposure timing unspecified 12.48 10.27 13 197314 370 34759234
Foetal heart rate deceleration abnormality 12.38 10.27 15 197312 506 34759098
Hepatitis E antibody positive 12.37 10.27 11 197316 256 34759348
Diverticular perforation 12.29 10.27 45 197282 3389 34756215
Communication disorder 12.12 10.27 37 197290 2537 34757067
Nephrotic syndrome 12.11 10.27 14 197313 7289 34752315
Alcoholic liver disease 12.06 10.27 16 197311 592 34759012
Foetal distress syndrome 12.04 10.27 22 197305 1078 34758526
Brain oedema 11.98 10.27 39 197288 13782 34745822
Asthma 11.97 10.27 169 197158 42487 34717117
Low set ears 11.96 10.27 14 197313 455 34759149
Nerve compression 11.76 10.27 43 197284 3236 34756368
Delirium 11.75 10.27 176 197151 43815 34715789
Nail bed inflammation 11.74 10.27 9 197318 169 34759435
Polydactyly 11.72 10.27 23 197304 1190 34758414
Bronchiolitis 11.68 10.27 42 197285 3134 34756470
Respiratory tract infection viral 11.68 10.27 36 197291 2481 34757123
Panniculitis 11.66 10.27 31 197296 1963 34757641
Hepatic enzyme increased 11.64 10.27 296 197031 38784 34720820
Interstitial lung disease 11.62 10.27 280 197047 65002 34694602
Haemangioma 11.62 10.27 30 197297 1867 34757737
Drug level increased 11.59 10.27 75 197252 22021 34737583
Nodule 11.58 10.27 72 197255 6747 34752857
Maternal exposure before pregnancy 11.56 10.27 18 197309 773 34758831
Cytomegalovirus chorioretinitis 11.53 10.27 3 197324 3586 34756018
Cytomegalovirus viraemia 11.52 10.27 15 197312 7415 34752189
Vascular insufficiency 11.51 10.27 12 197315 342 34759262
Educational problem 11.48 10.27 15 197312 547 34759057
Myelosuppression 11.36 10.27 63 197264 19202 34740402
Blood insulin increased 11.34 10.27 12 197315 348 34759256
Glycosylated haemoglobin increased 11.34 10.27 30 197297 11330 34748274
Anal atresia 11.34 10.27 11 197316 287 34759317
Hepatitis E virus test positive 11.31 10.27 11 197316 288 34759316
Nephropathy toxic 11.28 10.27 35 197292 12553 34747051
Neoplasm progression 11.27 10.27 81 197246 23219 34736385
Oxygen saturation decreased 11.23 10.27 390 196937 53428 34706176
Complications of transplanted kidney 11.22 10.27 6 197321 4603 34755001
Obsessive-compulsive disorder 11.16 10.27 9 197318 5555 34754049
Hepatic cirrhosis 11.15 10.27 148 197179 17166 34742438
Endophthalmitis 11.14 10.27 3 197324 3505 34756099
Blood creatine phosphokinase increased 11.13 10.27 182 197145 44675 34714929
Chronic obstructive pulmonary disease 11.10 10.27 358 196969 48560 34711044
Spina bifida 11.10 10.27 12 197315 357 34759247
Haemolysis 11.07 10.27 81 197246 8013 34751591
Abnormal behaviour 11.04 10.27 89 197238 24880 34734724
Hepatic steatosis 11.03 10.27 155 197172 18207 34741397
Weight increased 10.98 10.27 636 196691 92397 34667207
Heart rate irregular 10.98 10.27 137 197190 15670 34743934
Acute graft versus host disease in skin 10.96 10.27 8 197319 5193 34754411
Nephrolithiasis 10.96 10.27 236 197091 30097 34729507
Cholelithiasis 10.94 10.27 174 197153 20974 34738630
Hypermetropia 10.94 10.27 14 197313 500 34759104
Drug use disorder 10.89 10.27 5 197322 4186 34755418
Ear malformation 10.88 10.27 11 197316 302 34759302
Acute respiratory distress syndrome 10.83 10.27 94 197233 25875 34733729
Nail pitting 10.82 10.27 11 197316 304 34759300
Pulmonary alveolar haemorrhage 10.81 10.27 16 197311 7496 34752108
Pleural fibrosis 10.80 10.27 24 197303 1356 34758248
Gangrene neonatal 10.77 10.27 9 197318 192 34759412
Inguinal hernia 10.76 10.27 77 197250 7564 34752040
Psychomotor retardation 10.76 10.27 45 197282 3605 34755999
Cerebral infarction 10.74 10.27 101 197226 27354 34732250
Palindromic rheumatism 10.73 10.27 9 197318 193 34759411
Nail bed bleeding 10.73 10.27 12 197315 371 34759233
Cirrhosis alcoholic 10.72 10.27 18 197309 824 34758780
Pleuritic pain 10.71 10.27 44 197283 3497 34756107
Personality change 10.71 10.27 8 197319 5131 34754473
Hepatitis 10.66 10.27 85 197242 23819 34735785
Blood phosphorus increased 10.58 10.27 17 197310 7704 34751900
Pharyngeal disorder 10.55 10.27 17 197310 752 34758852
Necrotising fasciitis streptococcal 10.53 10.27 8 197319 148 34759456
Scarlet fever 10.52 10.27 7 197320 104 34759500
Rheumatoid lung 10.51 10.27 19 197308 923 34758681
Blood albumin decreased 10.47 10.27 120 197207 13452 34746152
Irritability 10.46 10.27 89 197238 24601 34735003
Joint instability 10.40 10.27 13 197314 453 34759151
Blood magnesium decreased 10.40 10.27 67 197260 6356 34753248
Red blood cell sedimentation rate abnormal 10.39 10.27 44 197283 3545 34756059
Haematotoxicity 10.35 10.27 19 197308 8175 34751429
Melaena 10.35 10.27 139 197188 35241 34724363
Rheumatoid vasculitis 10.34 10.27 10 197317 260 34759344
Haemophagocytic lymphohistiocytosis 10.31 10.27 38 197289 12935 34746669

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1190.55 10.08 163 563457 245604 78935164
Rheumatoid arthritis 1153.30 10.08 3666 559954 204804 78975964
Toxicity to various agents 934.64 10.08 961 562659 420579 78760189
Arthropathy 911.98 10.08 3040 560580 174071 79006697
Pemphigus 900.10 10.08 2099 561521 97483 79083285
Systemic lupus erythematosus 885.86 10.08 2355 561265 118794 79061974
Joint swelling 876.29 10.08 4199 559421 284447 78896321
Hand deformity 866.59 10.08 2123 561497 101796 79078972
Synovitis 832.39 10.08 2650 560970 148084 79032684
Glossodynia 776.00 10.08 2029 561591 101308 79079460
Drug abuse 757.37 10.08 121 563499 162570 79018198
Arthralgia 691.85 10.08 6615 557005 565188 78615580
Anti-cyclic citrullinated peptide antibody positive 665.03 10.08 1672 561948 81471 79099297
Wound 650.79 10.08 2053 561567 114126 79066642
Maternal exposure during pregnancy 616.95 10.08 2245 561375 134293 79046475
Pericarditis 593.94 10.08 1853 561767 102383 79078385
Infusion related reaction 571.89 10.08 3168 560452 227069 78953699
Abdominal discomfort 546.75 10.08 3333 560287 247394 78933374
Pain 505.62 10.08 7367 556253 696435 78484333
Discomfort 496.18 10.08 1979 561641 123638 79057130
Swelling 493.56 10.08 2914 560706 213797 78966971
Alopecia 483.93 10.08 3043 560577 228312 78952456
Drug interaction 482.13 10.08 1425 562195 413758 78767010
Therapeutic product effect decreased 473.67 10.08 2352 561268 161511 79019257
Musculoskeletal stiffness 424.96 10.08 2394 561226 172614 79008154
Duodenal ulcer perforation 420.36 10.08 1223 562397 64988 79115780
Helicobacter infection 416.39 10.08 1260 562360 68444 79112324
Contraindicated product administered 411.32 10.08 2198 561422 155340 79025428
Rheumatoid factor positive 398.99 10.08 1125 562495 58714 79122054
Death 398.32 10.08 2361 561259 564153 78616615
Intentional overdose 377.83 10.08 138 563482 105822 79074946
Drug intolerance 362.12 10.08 3142 560478 260977 78919791
Nasopharyngitis 361.62 10.08 3046 560574 250835 78929933
Psoriatic arthropathy 361.02 10.08 1293 562327 76706 79104062
Hepatic enzyme increased 347.53 10.08 2346 561274 180264 79000504
Febrile neutropenia 318.22 10.08 727 562893 230272 78950496
Exposure during pregnancy 300.89 10.08 1464 562156 99668 79081100
Impaired healing 271.67 10.08 1284 562336 86371 79094397
Acute kidney injury 263.29 10.08 2375 561245 517029 78663739
Hypersensitivity 237.12 10.08 2865 560755 259374 78921394
Peripheral swelling 234.88 10.08 2925 560695 266692 78914076
Depressed level of consciousness 231.57 10.08 205 563415 96447 79084321
Muscle injury 230.65 10.08 812 562808 47749 79133019
C-reactive protein abnormal 229.94 10.08 809 562811 47558 79133210
Folliculitis 227.81 10.08 884 562736 54496 79126272
Lower respiratory tract infection 226.80 10.08 1628 561992 127592 79053176
Sinusitis 221.21 10.08 2233 561387 193268 78987500
Irritable bowel syndrome 220.77 10.08 949 562671 61292 79119476
Suicide attempt 219.87 10.08 159 563461 82773 79097995
Treatment failure 219.43 10.08 2001 561619 168485 79012283
Cardiac arrest 210.90 10.08 575 563045 171521 79009247
Blister 210.11 10.08 1506 562114 117970 79062798
Overdose 209.26 10.08 638 562982 183568 78997200
Sickle cell anaemia with crisis 202.98 10.08 265 563355 7657 79173111
Red blood cell sedimentation rate abnormal 202.63 10.08 454 563166 20509 79160259
Sleep disorder due to general medical condition, insomnia type 200.60 10.08 721 562899 42835 79137933
Knee arthroplasty 195.02 10.08 711 562909 42537 79138231
Arthritis 191.66 10.08 1430 562190 113450 79067318
Osteoarthritis 186.35 10.08 1155 562465 86154 79094614
Product use issue 182.93 10.08 2277 561343 207545 78973223
Hip arthroplasty 180.36 10.08 610 563010 35146 79145622
Rhabdomyolysis 177.40 10.08 284 563336 102847 79077921
Blood pressure fluctuation 176.54 10.08 939 562681 66206 79114562
Weight increased 173.70 10.08 2840 560780 274546 78906222
Malignant neoplasm progression 171.41 10.08 448 563172 135542 79045226
Hepatic function abnormal 165.76 10.08 163 563457 72944 79107824
Respiratory arrest 163.75 10.08 102 563518 57448 79123320
Disease progression 163.47 10.08 708 562912 183654 78997114
Cardiac failure 161.46 10.08 557 563063 154285 79026483
Sopor 159.40 10.08 22 563598 32988 79147780
Renal failure 158.05 10.08 806 562814 200162 78980606
Neutropenia 156.89 10.08 1290 562330 286420 78894348
Rheumatic fever 151.31 10.08 495 563125 28030 79152738
Bradycardia 150.73 10.08 474 563146 135083 79045685
Sedation 149.01 10.08 91 563529 51804 79128964
Multiple organ dysfunction syndrome 147.85 10.08 401 563219 119845 79060923
Drug reaction with eosinophilia and systemic symptoms 147.09 10.08 142 563478 64102 79116666
Psoriasis 144.25 10.08 1106 562514 88481 79092287
Lactic acidosis 142.77 10.08 172 563448 70187 79110581
Drug resistance 140.57 10.08 61 563559 42152 79138616
Contusion 137.64 10.08 1633 561987 147143 79033625
Infection 135.04 10.08 2430 561190 239282 78941486
Intentional product misuse 134.60 10.08 295 563325 94870 79085898
Fibromyalgia 132.20 10.08 843 562777 63497 79117271
Pregnancy 131.84 10.08 454 563166 26397 79154371
Abortion spontaneous 129.58 10.08 481 563139 29026 79151742
Blood pressure systolic increased 129.31 10.08 864 562756 66122 79114646
Blood pressure systolic abnormal 126.62 10.08 336 563284 16911 79163857
Swollen joint count increased 126.26 10.08 403 563217 22524 79158244
Fatigue 123.27 10.08 7876 555744 921851 78258917
Ill-defined disorder 123.17 10.08 843 562777 65032 79115736
Cytomegalovirus infection 122.13 10.08 75 563545 42569 79138199
Blood pressure diastolic abnormal 122.11 10.08 355 563265 18847 79161921
Red blood cell sedimentation rate increased 120.42 10.08 642 562978 45300 79135468
Cardio-respiratory arrest 119.52 10.08 381 563239 108129 79072639
Poisoning deliberate 118.71 10.08 3 563617 18825 79161943
Renal impairment 118.33 10.08 643 562977 157140 79023628
Constipation 117.99 10.08 1355 562265 281695 78899073
Somnolence 114.64 10.08 1107 562513 237874 78942894
Condition aggravated 114.61 10.08 4477 559143 496647 78684121
Joint effusion 114.52 10.08 333 563287 17681 79163087
Hypoglycaemia 113.10 10.08 355 563265 101239 79079529
Product use in unapproved indication 112.51 10.08 1178 562442 249181 78931587
Neoplasm progression 111.75 10.08 120 563500 51562 79129206
Coma 111.13 10.08 353 563267 100296 79080472
Drug dependence 109.57 10.08 77 563543 40692 79140076
Respiratory failure 106.06 10.08 795 562825 180116 79000652
Poisoning 104.48 10.08 25 563595 25247 79155521
Grip strength decreased 104.10 10.08 366 563254 21503 79159265
Rash 101.06 10.08 5026 558594 573332 78607436
Pain in extremity 99.49 10.08 3323 560297 361215 78819553
Hypotension 98.63 10.08 2364 561256 437953 78742815
Serotonin syndrome 97.97 10.08 104 563516 44923 79135845
Hyperglycaemia 96.22 10.08 222 563398 70113 79110655
Inflammation 96.11 10.08 1050 562570 92703 79088065
C-reactive protein increased 95.66 10.08 1360 562260 127667 79053101
Injection site erythema 94.59 10.08 906 562714 77291 79103477
Intentional self-injury 92.86 10.08 57 563563 32362 79148406
Agitation 92.63 10.08 376 563244 99339 79081429
Thrombocytopenia 92.28 10.08 1319 562301 263940 78916828
Osteoporosis 91.57 10.08 676 562944 53436 79127332
Disseminated intravascular coagulation 90.78 10.08 72 563548 35770 79144998
Tachycardia 89.71 10.08 813 562807 176955 79003813
Blood pressure diastolic decreased 89.50 10.08 437 563183 29779 79150989
Foot deformity 89.17 10.08 372 563248 23702 79157066
Enthesopathy 89.15 10.08 230 563390 11378 79169390
Altered state of consciousness 89.04 10.08 107 563513 43715 79137053
Disability assessment scale score increased 86.00 10.08 114 563506 3344 79177424
Rheumatoid nodule 85.74 10.08 295 563325 17143 79163625
Musculoskeletal pain 84.95 10.08 1101 562519 101253 79079515
Hepatic failure 83.90 10.08 193 563427 61019 79119749
Stomatitis 82.81 10.08 1478 562142 145279 79035489
Gastrointestinal disorder 81.56 10.08 1265 562355 120940 79059828
Live birth 79.35 10.08 302 563318 18442 79162326
Hyponatraemia 78.57 10.08 840 562780 177008 79003760
Bone erosion 78.42 10.08 291 563329 17556 79163212
Blood cholesterol increased 77.85 10.08 920 562700 82800 79097968
Shock 77.66 10.08 117 563503 43431 79137337
Injection site reaction 77.64 10.08 657 562963 54128 79126640
Cholestasis 77.47 10.08 157 563463 51952 79128816
Hyperhidrosis 77.23 10.08 691 562929 150801 79029967
Juvenile idiopathic arthritis 76.63 10.08 128 563492 4635 79176133
Heart rate decreased 76.01 10.08 796 562824 69520 79111248
Tenosynovitis 75.49 10.08 262 563358 15292 79165476
Sedation complication 74.35 10.08 11 563609 15658 79165110
Angioedema 72.97 10.08 283 563337 75752 79105016
Electrocardiogram QT prolonged 71.86 10.08 361 563259 90025 79090743
Joint range of motion decreased 71.43 10.08 441 563179 32841 79147927
Joint stiffness 71.33 10.08 514 563106 40316 79140452
Ventricular tachycardia 69.74 10.08 118 563502 41817 79138951
Respiratory depression 69.35 10.08 56 563564 27574 79153194
Drug ineffective for unapproved indication 69.06 10.08 163 563457 51075 79129693
Anaemia 68.21 10.08 2515 561105 442500 78738268
Mobility decreased 67.70 10.08 1227 562393 120948 79059820
Polyarthritis 67.66 10.08 215 563405 11987 79168781
Syncope 67.52 10.08 878 562742 178571 79002197
Injection site pruritus 67.47 10.08 521 563099 41762 79139006
Joint destruction 67.26 10.08 137 563483 5788 79174980
Anaphylactic shock 66.84 10.08 94 563526 35902 79144866
Leukopenia 66.84 10.08 515 563105 115998 79064770
Cerebral haemorrhage 66.69 10.08 198 563422 57475 79123293
Hepatocellular injury 66.08 10.08 149 563471 47444 79133324
Intentional product use issue 66.07 10.08 1473 562147 150639 79030129
Cardiac failure congestive 65.16 10.08 667 562953 141735 79039033
Metabolic acidosis 64.82 10.08 331 563289 82198 79098570
Ventricular fibrillation 64.81 10.08 78 563542 31848 79148920
Caesarean section 64.22 10.08 215 563405 12320 79168448
Basal cell carcinoma 62.15 10.08 465 563155 36910 79143858
Suspected suicide 62.11 10.08 3 563617 10573 79170195
Palmar-plantar erythrodysaesthesia syndrome 62.05 10.08 86 563534 33048 79147720
Neurotoxicity 61.30 10.08 84 563536 32434 79148334
Drug withdrawal syndrome 61.21 10.08 94 563526 34624 79146144
Myocardial infarction 61.07 10.08 924 562696 183205 78997563
Localised infection 60.52 10.08 464 563156 37111 79143657
Hyperkalaemia 60.42 10.08 517 563103 113881 79066887
Injection site pain 59.47 10.08 1267 562353 128571 79052197
Joint laxity 59.42 10.08 78 563542 2266 79178502
Orthostatic hypotension 59.21 10.08 201 563419 55963 79124805
Venoocclusive liver disease 58.87 10.08 7 563613 11764 79169004
Pulmonary fibrosis 58.85 10.08 522 563098 43590 79137178
Loss of personal independence in daily activities 58.52 10.08 1035 562585 101545 79079223
Vomiting 58.08 10.08 3989 559631 661839 78518929
Acute hepatic failure 57.56 10.08 77 563543 30036 79150732
Hypoxia 57.52 10.08 460 563160 102783 79077985
Cognitive disorder 57.47 10.08 276 563344 69650 79111118
Drug ineffective 56.42 10.08 8580 555040 1072333 78108435
Blood creatine phosphokinase increased 56 10.08 258 563362 65832 79114936
Cardiogenic shock 55.96 10.08 134 563486 41780 79138988
Tendonitis 55.12 10.08 322 563298 23508 79157260
Aspergillus infection 54.45 10.08 34 563586 19127 79161641
Blood pressure diastolic increased 54.08 10.08 225 563395 14317 79166451
Agranulocytosis 53.96 10.08 152 563468 44878 79135890
Gestational diabetes 53.92 10.08 130 563490 6163 79174605
Mydriasis 53.41 10.08 29 563591 17614 79163154
Immune reconstitution inflammatory syndrome 52.86 10.08 16 563604 13825 79166943
Cerebral infarction 52.68 10.08 157 563463 45519 79135249
Neutrophil count decreased 52.64 10.08 418 563202 93541 79087227
Body temperature decreased 52.36 10.08 398 563222 31747 79149021
Second primary malignancy 52.31 10.08 18 563602 14332 79166436
Injection site swelling 52.09 10.08 536 563084 46596 79134172
Nodule 51.45 10.08 308 563312 22686 79158082
Disability 50.99 10.08 248 563372 16872 79163896
Red blood cell sedimentation rate 50.98 10.08 118 563502 5447 79175321
Creatinine renal clearance decreased 50.92 10.08 36 563584 18966 79161802
Substance abuse 50.86 10.08 7 563613 10519 79170249
Adverse event 50.49 10.08 649 562971 59565 79121203
Type 2 diabetes mellitus 49.74 10.08 620 563000 56502 79124266
No adverse event 49.58 10.08 119 563501 37073 79143695
Tongue disorder 49.47 10.08 213 563407 13762 79167006
Thrombotic microangiopathy 49.24 10.08 42 563578 20127 79160641
Alanine aminotransferase abnormal 48.95 10.08 156 563464 8711 79172057
Pathogen resistance 48.91 10.08 20 563600 14322 79166446
Blood pressure increased 48.32 10.08 1889 561731 209471 78971297
Abnormal behaviour 48.18 10.08 117 563503 36304 79144464
Cytokine release syndrome 48.13 10.08 115 563505 35883 79144885
Neuropathy peripheral 47.91 10.08 706 562914 140599 79040169
Asphyxia 47.66 10.08 12 563608 11708 79169060
Disturbance in attention 47.52 10.08 191 563429 50610 79130158
Posterior reversible encephalopathy syndrome 47.45 10.08 70 563550 26211 79154557
Torsade de pointes 47.41 10.08 40 563580 19272 79161496
Myelosuppression 46.84 10.08 138 563482 40158 79140610
Drug use disorder 46.24 10.08 4 563616 8647 79172121
Wrong technique in product usage process 45.99 10.08 319 563301 73556 79107212
Hallucination 45.95 10.08 386 563234 85359 79095409
Ejection fraction decreased 45.80 10.08 111 563509 34466 79146302
Bronchopulmonary aspergillosis 45.75 10.08 54 563566 22240 79158528
Transplant rejection 45.61 10.08 42 563578 19395 79161373
Appendicolith 45.58 10.08 4 563616 8547 79172221
Neuroleptic malignant syndrome 45.41 10.08 78 563542 27481 79153287
Osteonecrosis of jaw 45.36 10.08 155 563465 43071 79137697
Femur fracture 45.34 10.08 445 563175 38207 79142561
Psychotic disorder 45.13 10.08 146 563474 41256 79139512
Tenderness 45.04 10.08 304 563316 23338 79157430
Myalgia 45.04 10.08 984 562636 184657 78996111
Brain oedema 44.92 10.08 68 563552 25195 79155573
Haematotoxicity 44.84 10.08 27 563593 15492 79165276
Restlessness 44.63 10.08 173 563447 46319 79134449
Injection site bruising 44.23 10.08 464 563156 40538 79140230
Acute graft versus host disease 44.17 10.08 9 563611 10158 79170610
Ear infection 44.16 10.08 404 563216 34028 79146740
Dyspnoea 44.08 10.08 5345 558275 851680 78329088
Tremor 44.05 10.08 892 562728 169191 79011577
Laryngitis 44.00 10.08 227 563393 15812 79164956
Seizure 43.80 10.08 1008 562612 187826 78992942
Sepsis 43.41 10.08 1513 562107 267915 78912853
Drug level increased 43.10 10.08 140 563480 39511 79141257
Unintentional medical device removal 42.81 10.08 3 563617 7709 79173059
Disorientation 42.66 10.08 264 563356 62512 79118256
Synovial cyst 42.47 10.08 162 563458 9903 79170865
Withdrawal syndrome 42.45 10.08 78 563542 26776 79153992
Oropharyngeal pain 42.26 10.08 1042 562578 108311 79072457
Latent tuberculosis 42.25 10.08 81 563539 3272 79177496
Nausea 42.21 10.08 6028 557592 951168 78229600
Exposure to toxic agent 42.16 10.08 7 563613 9151 79171617
Blood creatinine increased 42.03 10.08 807 562813 154250 79026518
Blood glucose increased 41.97 10.08 566 563054 114409 79066359
Encephalopathy 41.97 10.08 291 563329 67106 79113662
Ascites 41.93 10.08 337 563283 75225 79105543
Melaena 41.93 10.08 255 563365 60635 79120133
Off label use 41.90 10.08 5697 557923 901518 78279250
Exostosis 41.76 10.08 232 563388 16626 79164142
Proteinuria 41.75 10.08 106 563514 32396 79148372
Akathisia 41.31 10.08 21 563599 13238 79167530
Hypokalaemia 41.11 10.08 743 562877 143297 79037471
Acute respiratory distress syndrome 41.02 10.08 166 563454 43901 79136867
Dehydration 40.84 10.08 1390 562230 246797 78933971
Coronary artery disease 40.62 10.08 283 563337 65191 79115577
Vision blurred 40.23 10.08 517 563103 105381 79075387
Rash maculo-papular 40.12 10.08 232 563388 55846 79124922
Neck mass 39.92 10.08 93 563527 4311 79176457
Skin ulcer 39.80 10.08 570 563050 53580 79127188
Aggression 39.10 10.08 206 563414 50752 79130016
Fracture 38.98 10.08 276 563344 21525 79159243
Suicidal ideation 38.98 10.08 348 563272 75992 79104776
Hyperthermia 38.86 10.08 42 563578 17995 79162773
Neck deformity 38.84 10.08 56 563564 1781 79178987
Haemophagocytic lymphohistiocytosis 38.61 10.08 59 563561 21778 79158990
Speech disorder 38.55 10.08 226 563394 54219 79126549
Anaphylactic reaction 38.40 10.08 392 563228 83351 79097417
Miosis 38.39 10.08 33 563587 15756 79165012
Blood parathyroid hormone decreased 38.39 10.08 162 563458 10374 79170394
Gamma-glutamyltransferase increased 38.17 10.08 228 563392 54452 79126316
Acute chest syndrome 38.11 10.08 51 563569 1510 79179258
Loss of consciousness 37.96 10.08 900 562720 167043 79013725
Lupus-like syndrome 37.93 10.08 196 563424 13661 79167107
Bursitis 37.90 10.08 404 563216 35440 79145328
Joint injury 37.85 10.08 363 563257 30972 79149796
Irritability 37.66 10.08 156 563464 40988 79139780
Inappropriate antidiuretic hormone secretion 37.66 10.08 81 563539 26232 79154536
Asthma 37.57 10.08 700 562920 134395 79046373
Extrapyramidal disorder 37.54 10.08 64 563556 22615 79158153
Ischaemic stroke 37.40 10.08 115 563505 33016 79147752
Injection site rash 37.34 10.08 236 563384 17718 79163050
Myoclonus 37.27 10.08 88 563532 27572 79153196
Respiratory distress 37.26 10.08 250 563370 58089 79122679
Tuberculosis 36.88 10.08 208 563412 14990 79165778
Colorectal cancer 36.85 10.08 8 563612 8639 79172129
Pyrexia 36.74 10.08 4218 559402 674491 78506277
Eosinophilia 36.67 10.08 180 563440 45165 79135603
Diabetic ketoacidosis 36.04 10.08 122 563498 34000 79146768
Maternal exposure before pregnancy 36.04 10.08 89 563531 4284 79176484
BK virus infection 35.83 10.08 9 563611 8795 79171973
Wheelchair user 35.80 10.08 110 563510 6022 79174746
Granuloma skin 35.74 10.08 144 563476 9030 79171738
Arthritis infective 35.62 10.08 134 563486 8137 79172631
Peripheral venous disease 35.53 10.08 213 563407 15696 79165072
Multiple fractures 35.37 10.08 131 563489 7895 79172873
Coagulopathy 35.20 10.08 133 563487 35873 79144895
Acute generalised exanthematous pustulosis 35.19 10.08 42 563578 17212 79163556
Facet joint syndrome 34.58 10.08 165 563455 11137 79169631
Pre-eclampsia 34.52 10.08 119 563501 6922 79173846
Stress cardiomyopathy 34.32 10.08 18 563602 11148 79169620
Tachypnoea 34.30 10.08 114 563506 31949 79148819
Pulmonary oedema 34.22 10.08 429 563191 87825 79092943
Paradoxical drug reaction 34.19 10.08 5 563615 7180 79173588
Anxiety 34.18 10.08 1422 562198 247090 78933678
Disease recurrence 34.01 10.08 178 563442 43931 79136837
Erythema multiforme 33.87 10.08 45 563575 17606 79163162
Arrhythmia 33.66 10.08 274 563346 60998 79119770
Ankylosing spondylitis 33.66 10.08 173 563447 12032 79168736
Bronchospasm 33.56 10.08 79 563541 24780 79155988
Lip dry 33.52 10.08 205 563415 15213 79165555
Graft versus host disease 33.48 10.08 34 563586 14992 79165776
Accidental overdose 33.24 10.08 155 563465 39426 79141342
Atrial fibrillation 33.08 10.08 1106 562514 196780 78983988
Clostridium difficile colitis 33.04 10.08 117 563503 32166 79148602
Joint dislocation 32.99 10.08 219 563401 16720 79164048
Smear cervix abnormal 32.87 10.08 62 563558 2474 79178294
Limb deformity 32.75 10.08 76 563544 3514 79177254
Hypothermia 32.57 10.08 70 563550 22676 79158092
Premature labour 32.14 10.08 131 563489 8259 79172509
Fear of injection 32.12 10.08 121 563499 7353 79173415
Interstitial lung disease 32.07 10.08 581 563039 112019 79068749
Maternal exposure timing unspecified 32.06 10.08 102 563518 5690 79175078
Status epilepticus 31.91 10.08 82 563538 24959 79155809
Panniculitis 31.82 10.08 172 563448 12199 79168569
Therapeutic response decreased 31.78 10.08 656 562964 66197 79114571
Forced expiratory volume decreased 31.77 10.08 8 563612 7806 79172962
Cytopenia 31.52 10.08 60 563560 20323 79160445
Pancreatitis acute 31.47 10.08 213 563407 49391 79131377
Poor venous access 31.42 10.08 228 563392 17921 79162847
Spinal stenosis 31.26 10.08 205 563415 15586 79165182
Graft versus host disease in gastrointestinal tract 31.25 10.08 4 563616 6352 79174416
Gastroenteritis viral 31.16 10.08 290 563330 24541 79156227
Rotator cuff repair 31.09 10.08 51 563569 1819 79178949
Chronic kidney disease 31.02 10.08 308 563312 65846 79114922
Chest discomfort 30.85 10.08 741 562879 137303 79043465
Premature rupture of membranes 30.61 10.08 80 563540 3989 79176779
Anuria 30.45 10.08 64 563556 20899 79159869
Asthenia 30.43 10.08 3159 560461 508530 78672238
Blood calcium decreased 30.16 10.08 119 563501 31700 79149068
Scleritis 30.10 10.08 83 563537 4273 79176495
Adenovirus infection 30.10 10.08 11 563609 8436 79172332
Retinitis 29.99 10.08 98 563522 5545 79175223
Toxic skin eruption 29.97 10.08 71 563549 22222 79158546
Premature delivery 29.92 10.08 275 563345 23192 79157576
Mania 29.80 10.08 52 563568 18208 79162560
Cytomegalovirus viraemia 29.74 10.08 28 563592 12793 79167975
Malignant mediastinal neoplasm 29.72 10.08 43 563577 1372 79179396
Hepatitis B reactivation 29.66 10.08 4 563616 6104 79174664
Acute myeloid leukaemia 29.60 10.08 115 563505 30770 79149998
Angina pectoris 29.50 10.08 229 563391 51503 79129265
Ulcer 29.47 10.08 333 563287 29639 79151129
Face oedema 29.44 10.08 101 563519 28035 79152733
Deep vein thrombosis postoperative 29.37 10.08 152 563468 10600 79170168
Dysarthria 29.19 10.08 321 563299 67301 79113467
Haemoptysis 29.15 10.08 254 563366 55745 79125023
Balance disorder 29.13 10.08 507 563113 98350 79082418
Wound infection 29.02 10.08 278 563342 23713 79157055
Platelet count decreased 28.89 10.08 1104 562516 193560 78987208
Metastases to bone 28.86 10.08 83 563537 24344 79156424
Adjustment disorder with depressed mood 28.79 10.08 134 563486 8952 79171816
Pulmonary embolism 28.78 10.08 959 562661 170695 79010073
Anti-cyclic citrullinated peptide antibody 28.77 10.08 99 563521 5753 79175015
Bone disorder 28.57 10.08 232 563388 18881 79161887
Product quality issue 28.45 10.08 133 563487 33807 79146961
Skin papilloma 28.44 10.08 99 563521 5787 79174981
Psychomotor hyperactivity 28.40 10.08 47 563573 16802 79163966
Klebsiella infection 28.25 10.08 42 563578 15678 79165090
Metastases to liver 28.06 10.08 104 563516 28210 79152558
Tumour lysis syndrome 27.81 10.08 82 563538 23857 79156911
Pulmonary alveolar haemorrhage 27.79 10.08 24 563596 11433 79169335
Unresponsive to stimuli 27.31 10.08 257 563363 55531 79125237
Foot fracture 27.23 10.08 256 563364 21725 79159043
Blood pressure decreased 27.15 10.08 517 563103 98949 79081819
Aphasia 27.05 10.08 206 563414 46526 79134242
Weight decreased 27.05 10.08 2887 560733 352311 78828457
Sciatica 26.98 10.08 356 563264 32866 79147902
Nocardiosis 26.92 10.08 4 563616 5675 79175093
Device difficult to use 26.85 10.08 33 563587 13352 79167416
Tenosynovitis stenosans 26.82 10.08 64 563556 3014 79177754
Haemorrhage intracranial 26.75 10.08 95 563525 26098 79154670
Drug tolerance decreased 26.62 10.08 170 563450 12808 79167960
Hypertransaminasaemia 26.55 10.08 27 563593 11897 79168871
Pemphigoid 26.49 10.08 42 563578 15273 79165495
Cystitis haemorrhagic 26.44 10.08 16 563604 9156 79171612
Liver injury 26.41 10.08 554 563066 56060 79124708
Sexual dysfunction 26.19 10.08 11 563609 7752 79173016
Synovial fluid analysis 26.14 10.08 54 563566 2305 79178463
Influenza 25.87 10.08 1142 562478 128464 79052304
Temperature regulation disorder 25.80 10.08 5 563615 5848 79174920
Cerebrovascular accident 25.70 10.08 869 562751 154423 79026345
Emotional distress 25.66 10.08 171 563449 39798 79140970
Chronic graft versus host disease 25.61 10.08 8 563612 6773 79173995
Acute graft versus host disease in skin 25.60 10.08 11 563609 7647 79173121
Delirium 25.59 10.08 432 563188 84195 79096573
Dislocation of vertebra 25.55 10.08 117 563503 7763 79173005
Accidental exposure to product 25.52 10.08 124 563496 31198 79149570
Skin cancer 25.50 10.08 188 563432 14852 79165916
Stevens-Johnson syndrome 25.43 10.08 167 563453 38999 79141769
Dermatitis acneiform 25.40 10.08 20 563600 9973 79170795
Acute myocardial infarction 25.38 10.08 387 563233 76649 79104119
Shock haemorrhagic 25.32 10.08 66 563554 19994 79160774
Blood bilirubin increased 25.28 10.08 323 563297 65909 79114859
Labelled drug-drug interaction medication error 25.21 10.08 105 563515 27545 79153223
Cyst 25.20 10.08 176 563444 13664 79167104
Febrile bone marrow aplasia 25.18 10.08 33 563587 12987 79167781
Breast cancer stage I 25.13 10.08 8 563612 6692 79174076
Mental status changes 25.02 10.08 328 563292 66631 79114137
Bradyphrenia 24.96 10.08 23 563597 10617 79170151
Hyperuricaemia 24.84 10.08 28 563592 11771 79168997
Lymphocyte count decreased 24.83 10.08 214 563406 47075 79133693
Cardiotoxicity 24.74 10.08 30 563590 12209 79168559
Rheumatoid lung 24.64 10.08 76 563544 4169 79176599
Glycosylated haemoglobin increased 24.59 10.08 63 563557 19197 79161571
Hepatotoxicity 24.53 10.08 238 563382 51114 79129654
Haemoglobin decreased 24.52 10.08 1855 561765 220264 78960504
White blood cell count decreased 24.50 10.08 1084 562536 187204 78993564
Blood alkaline phosphatase increased 24.48 10.08 310 563310 63354 79117414
Pulmonary arterial hypertension 24.46 10.08 110 563510 28256 79152512
Oliguria 24.36 10.08 49 563571 16260 79164508
Dystonia 24.35 10.08 74 563546 21325 79159443
Fear 24.33 10.08 77 563543 21909 79158859
Product administration error 24.28 10.08 129 563491 31717 79149051
Ileus 24.23 10.08 99 563521 26112 79154656
Herpes zoster 24.17 10.08 844 562776 92239 79088529
Cardiac failure chronic 23.91 10.08 26 563594 11109 79169659
Loose body in joint 23.84 10.08 37 563583 1258 79179510
Multiple sclerosis relapse 23.80 10.08 212 563408 46321 79134447
Malignant melanoma 23.72 10.08 182 563438 14559 79166209
Gastrointestinal haemorrhage 23.66 10.08 830 562790 146889 79033879
Obesity 23.57 10.08 364 563256 34761 79146007
Mouth ulceration 23.56 10.08 392 563228 38002 79142766
Urticaria 23.53 10.08 1069 562551 184132 78996636
Diarrhoea 23.50 10.08 5693 557927 874796 78305972
Antinuclear antibody positive 23.28 10.08 114 563506 7776 79172992
Myocardial ischaemia 23.20 10.08 97 563523 25422 79155346
Decreased appetite 23.13 10.08 2094 561526 340324 78840444
Hemiplegia 23.08 10.08 44 563576 14895 79165873
Fracture delayed union 23.02 10.08 48 563572 2062 79178706
Nephropathy toxic 22.96 10.08 71 563549 20348 79160420
Dyskinesia 22.90 10.08 204 563416 44569 79136199
Synovial disorder 22.69 10.08 46 563574 1937 79178831
Pancytopenia 22.65 10.08 1409 562211 164336 79016432
Device use error 22.49 10.08 11 563609 7090 79173678
Electrocardiogram QRS complex prolonged 22.49 10.08 26 563594 10807 79169961
Infective pulmonary exacerbation of cystic fibrosis 22.46 10.08 35 563585 12816 79167952
Immunodeficiency 22.39 10.08 244 563376 21524 79159244
Hepatic cirrhosis 22.39 10.08 359 563261 34547 79146221
Injection site warmth 22.27 10.08 180 563440 14627 79166141
Therapy partial responder 22.14 10.08 57 563563 17340 79163428
Metastases to central nervous system 22.14 10.08 52 563568 16323 79164445
Vertigo 22.09 10.08 349 563271 68733 79112035
Joint noise 22.01 10.08 70 563550 3904 79176864
Blood lactic acid increased 21.99 10.08 35 563585 12709 79168059
Affective disorder 21.98 10.08 16 563604 8303 79172465
Pleural effusion 21.95 10.08 822 562798 144440 79036328
Rhinorrhoea 21.85 10.08 698 562922 75376 79105392
Hemiparesis 21.82 10.08 144 563476 33589 79147179
Hyperbilirubinaemia 21.80 10.08 94 563526 24424 79156344
Epstein-Barr virus infection 21.80 10.08 43 563577 14373 79166395
Oral herpes 21.80 10.08 293 563327 27161 79153607
Hyperthyroidism 21.73 10.08 82 563538 22127 79158641
Pruritus genital 21.63 10.08 3 563617 4483 79176285
Hallucination, visual 21.53 10.08 139 563481 32590 79148178
Graft versus host disease in skin 21.48 10.08 8 563612 6065 79174703
Hydrops foetalis 21.47 10.08 27 563593 751 79180017
Finger deformity 21.35 10.08 107 563513 7367 79173401
Polyneuropathy 21.22 10.08 93 563527 24058 79156710
Sinus tachycardia 21.22 10.08 163 563457 36745 79144023
Cardiac failure acute 21.16 10.08 66 563554 18863 79161905
Haematocrit decreased 20.99 10.08 575 563045 60737 79120031
Leukocytosis 20.92 10.08 201 563419 43254 79137514
Cyanosis 20.92 10.08 99 563521 25083 79155685
Multiple-drug resistance 20.71 10.08 19 563601 8789 79171979
Ultrasound antenatal screen 20.65 10.08 25 563595 668 79180100
Hyperprolactinaemia 20.60 10.08 4 563616 4672 79176096
Haemodynamic instability 20.58 10.08 59 563561 17323 79163445
Hyperammonaemia 20.56 10.08 29 563591 11064 79169704
Hallucination, auditory 20.51 10.08 76 563544 20617 79160151
Cleft lip and palate 20.51 10.08 25 563595 673 79180095
Enterocolitis 20.50 10.08 45 563575 14467 79166301
Bladder cancer 20.49 10.08 70 563550 19456 79161312
Peripheral sensory neuropathy 20.47 10.08 38 563582 12995 79167773
Anhedonia 20.39 10.08 47 563573 14851 79165917
Endophthalmitis 20.30 10.08 10 563610 6418 79174350
Transplant dysfunction 20.26 10.08 13 563607 7208 79173560
Cytomegalovirus infection reactivation 20.26 10.08 19 563601 8697 79172071
Pleuritic pain 20.22 10.08 132 563488 10020 79170748
Septic shock 20.12 10.08 688 562932 122113 79058655
Pancreatitis 20.11 10.08 352 563268 68223 79112545
Bronchitis 20.01 10.08 1122 562498 129522 79051246
Sinus bradycardia 19.96 10.08 101 563519 25146 79155622
Palpitations 19.91 10.08 713 562907 125897 79054871
Human antichimeric antibody positive 19.89 10.08 39 563581 1602 79179166
Cytomegalovirus chorioretinitis 19.82 10.08 7 563613 5483 79175285
Atrial tachycardia 19.80 10.08 13 563607 7120 79173648
Virologic failure 19.75 10.08 3 563617 4188 79176580
Respiratory disorder 19.73 10.08 212 563408 44644 79136124
Potentiating drug interaction 19.60 10.08 20 563600 8799 79171969
Haemorrhage 19.57 10.08 492 563128 90626 79090142
Nasal polyps 19.47 10.08 14 563606 7313 79173455
Jaundice cholestatic 19.46 10.08 31 563589 11253 79169515
Flushing 19.39 10.08 475 563145 87793 79092975
Lip swelling 19.37 10.08 190 563430 40721 79140047
Ingrown hair 19.32 10.08 25 563595 716 79180052
Sleep terror 19.25 10.08 4 563616 4454 79176314
Product prescribing error 19.23 10.08 213 563407 44600 79136168
Purpura 19.17 10.08 72 563548 19455 79161313
Hepatitis fulminant 19.14 10.08 14 563606 7248 79173520
Muscle twitching 19.06 10.08 100 563520 24664 79156104
Multiple drug therapy 19.04 10.08 3 563617 4075 79176693
Obstructive airways disorder 19.01 10.08 137 563483 31322 79149446
Renal injury 18.93 10.08 59 563561 16868 79163900
Progressive multifocal leukoencephalopathy 18.92 10.08 78 563542 20522 79160246
Pulmonary congestion 18.91 10.08 113 563507 26987 79153781
Eosinophil count increased 18.86 10.08 60 563560 17045 79163723
Urinary retention 18.82 10.08 284 563336 56346 79124422
Acute coronary syndrome 18.80 10.08 81 563539 21052 79159716
Tubulointerstitial nephritis 18.77 10.08 176 563444 38059 79142709
Oxygen saturation decreased 18.75 10.08 1103 562517 127944 79052824
Pneumatosis intestinalis 18.67 10.08 11 563609 6386 79174382
Post procedural infection 18.56 10.08 141 563479 11243 79169525
Lower limb fracture 18.53 10.08 248 563372 22967 79157801
Rash pruritic 18.48 10.08 649 562971 70980 79109788
Metastases to lung 18.47 10.08 66 563554 18097 79162671
Procedural pain 18.45 10.08 92 563528 22992 79157776
Personality change 18.44 10.08 27 563593 10143 79170625
Bone pain 18.37 10.08 280 563340 55462 79125306
Body height below normal 18.22 10.08 43 563577 2010 79178758
Maternal exposure during breast feeding 18.20 10.08 52 563568 2733 79178035
Trisomy 18 18.20 10.08 22 563598 587 79180181
Ankle arthroplasty 18.19 10.08 36 563584 1489 79179279
Respiratory acidosis 18.18 10.08 32 563588 11168 79169600
Postoperative wound infection 18.13 10.08 155 563465 12806 79167962
Pseudomonas infection 18.06 10.08 81 563539 20822 79159946
Osteopenia 18.04 10.08 204 563416 18160 79162608
Dysphagia 18.04 10.08 693 562927 121443 79059325
Lymphopenia 18.02 10.08 134 563486 30423 79150345
End stage renal disease 18.01 10.08 37 563583 12183 79168585
Venoocclusive disease 17.99 10.08 5 563615 4568 79176200
Hepatitis cholestatic 17.93 10.08 45 563575 13807 79166961
Autoimmune disorder 17.92 10.08 188 563432 16424 79164344
Rebound effect 17.70 10.08 15 563605 7211 79173557
Oesophageal carcinoma 17.69 10.08 32 563588 11052 79169716
General physical health deterioration 17.69 10.08 2213 561407 273025 78907743
Aspartate aminotransferase increased 17.66 10.08 800 562820 137841 79042927
Viral mutation identified 17.65 10.08 3 563617 3855 79176913
Device related infection 17.65 10.08 156 563464 34138 79146630
Subdural haematoma 17.52 10.08 140 563480 31294 79149474
Hepatitis acute 17.51 10.08 54 563566 15488 79165280
Bacteraemia 17.48 10.08 148 563472 32676 79148092
Polyhydramnios 17.47 10.08 38 563582 1682 79179086
Device expulsion 17.44 10.08 109 563511 25752 79155016
Onychomycosis 17.43 10.08 109 563511 8152 79172616
Drug tolerance 17.40 10.08 113 563507 8562 79172206
Pulmonary haemorrhage 17.39 10.08 50 563570 14667 79166101
Skin necrosis 17.36 10.08 200 563420 17887 79162881
Injection site haemorrhage 17.26 10.08 285 563335 27585 79153183
Gastric haemorrhage 17.16 10.08 52 563568 14998 79165770
Parkinsonism 17.04 10.08 60 563560 16524 79164244
Foot operation 17.04 10.08 83 563537 5650 79175118
Breast feeding 16.98 10.08 23 563597 689 79180079
Hypoalbuminaemia 16.95 10.08 85 563535 21212 79159556
Blood lactate dehydrogenase increased 16.88 10.08 186 563434 38984 79141784
Colitis ulcerative 16.87 10.08 342 563278 34400 79146368
Short stature 16.86 10.08 23 563597 694 79180074
Disturbance in social behaviour 16.84 10.08 7 563613 4963 79175805
Acidosis 16.82 10.08 77 563543 19685 79161083
Pulseless electrical activity 16.81 10.08 48 563572 14112 79166656
Foetal distress syndrome 16.74 10.08 19 563601 473 79180295
Glomerular filtration rate decreased 16.74 10.08 93 563527 22609 79158159
Surgery 16.73 10.08 325 563295 32441 79148327
Vascular stent thrombosis 16.72 10.08 3 563617 3707 79177061
Musculoskeletal disorder 16.66 10.08 228 563392 21220 79159548
Heart rate irregular 16.64 10.08 324 563296 32355 79148413
Injury 16.62 10.08 688 562932 76808 79103960
COVID-19 16.57 10.08 928 562692 156746 79024022
Rhinitis allergic 16.55 10.08 39 563581 12230 79168538
Accidental death 16.32 10.08 5 563615 4286 79176482
Mental disorder 16.28 10.08 142 563478 31160 79149608
Hepatic cancer 16.27 10.08 31 563589 10498 79170270
Placental disorder 16.26 10.08 26 563594 907 79179861
Coordination abnormal 16.24 10.08 65 563555 17247 79163521
Prescribed overdose 16.16 10.08 366 563254 37517 79143251
Paralysis 16.14 10.08 44 563576 13133 79167635
Blood urea increased 16.10 10.08 245 563375 48545 79132223
Acute respiratory failure 16.09 10.08 310 563310 59231 79121537
Haematuria 16.07 10.08 367 563253 68469 79112299
Personality disorder 16.00 10.08 12 563608 6134 79174634
Normal newborn 15.99 10.08 95 563525 6977 79173791
Pharyngitis streptococcal 15.98 10.08 130 563490 10584 79170184
Lipase increased 15.98 10.08 61 563559 16405 79164363
Dysgeusia 15.97 10.08 296 563324 56881 79123887
Device leakage 15.89 10.08 33 563587 10823 79169945
Respiration abnormal 15.84 10.08 19 563601 7769 79172999
Strongyloidiasis 15.83 10.08 4 563616 3894 79176874
Endodontic procedure 15.82 10.08 49 563571 2694 79178074
Intervertebral disc degeneration 15.80 10.08 176 563444 15609 79165159
Fluid retention 15.79 10.08 374 563246 69435 79111333
Dizziness 15.73 10.08 3385 560235 523056 78657712
Injection site urticaria 15.70 10.08 149 563471 12677 79168091
Alcoholic liver disease 15.69 10.08 20 563600 564 79180204
Decreased gait velocity 15.68 10.08 12 563608 177 79180591
Atrioventricular block 15.66 10.08 49 563571 13992 79166776
Polyuria 15.64 10.08 54 563566 14960 79165808
Amylase increased 15.63 10.08 35 563585 11174 79169594
Neck pain 15.59 10.08 667 562953 74750 79106018
Jaundice 15.59 10.08 274 563346 53075 79127693
Coronary artery bypass 15.57 10.08 12 563608 6050 79174718
Bradypnoea 15.52 10.08 12 563608 6040 79174728
Ventricular arrhythmia 15.52 10.08 24 563596 8816 79171952
Pain in jaw 15.49 10.08 231 563389 45920 79134848
Radiation inflammation 15.48 10.08 25 563595 880 79179888
Acute lymphocytic leukaemia recurrent 15.45 10.08 7 563613 4717 79176051
Bone marrow failure 15.41 10.08 261 563359 50846 79129922
Cushingoid 15.40 10.08 118 563502 9434 79171334
Cholangitis 15.40 10.08 43 563577 12733 79168035
Knee operation 15.39 10.08 82 563538 5784 79174984
Right ventricular failure 15.35 10.08 100 563520 23397 79157371
Pulmonary hypertension 15.34 10.08 243 563377 47837 79132931
Antibody test positive 15.30 10.08 49 563571 2743 79178025
Hypertriglyceridaemia 15.27 10.08 43 563577 12697 79168071
Depression 15.17 10.08 1322 562298 215468 78965300
Sickle cell anaemia 15.16 10.08 21 563599 643 79180125
Skin toxicity 15.15 10.08 22 563598 8292 79172476
Deformity 15.13 10.08 118 563502 9487 79171281
Kidney transplant rejection 15.12 10.08 31 563589 10215 79170553
Sleep disorder due to a general medical condition 15.11 10.08 51 563569 14226 79166542
Bone cyst 15.10 10.08 56 563564 3377 79177391
Type 1 diabetes mellitus 15.03 10.08 16 563604 6903 79173865
Hypercapnia 14.99 10.08 25 563595 8910 79171858
COVID-19 pneumonia 14.95 10.08 131 563489 28718 79152050
Hypoxic-ischaemic encephalopathy 14.94 10.08 20 563600 7800 79172968
Appendicitis 14.89 10.08 86 563534 20708 79160060
Chronic sinusitis 14.86 10.08 45 563575 12981 79167787
Acute graft versus host disease in intestine 14.85 10.08 5 563615 4036 79176732
Prostatic specific antigen increased 14.84 10.08 32 563588 10354 79170414
Diaphragmatic disorder 14.83 10.08 36 563584 1714 79179054
Encephalitis toxic 14.83 10.08 14 563606 279 79180489
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.82 10.08 4 563616 3725 79177043
Induced labour 14.79 10.08 24 563596 848 79179920
Hypomania 14.72 10.08 19 563601 7525 79173243
Blood phosphorus increased 14.68 10.08 32 563588 10315 79170453
Haematoma 14.64 10.08 270 563350 51925 79128843
Lacrimal disorder 14.58 10.08 18 563602 491 79180277
Diabetes mellitus 14.57 10.08 432 563188 77958 79102810
Stillbirth 14.56 10.08 61 563559 3894 79176874
Heparin-induced thrombocytopenia 14.54 10.08 29 563591 9653 79171115
International normalised ratio increased 14.50 10.08 472 563148 84249 79096519
Diabetes mellitus inadequate control 14.50 10.08 106 563514 24158 79156610
Kidney infection 14.49 10.08 226 563394 21625 79159143
Hyperlactacidaemia 14.47 10.08 11 563609 5584 79175184
Immunosuppressant drug level increased 14.46 10.08 26 563594 9001 79171767
Erectile dysfunction 14.44 10.08 54 563566 14610 79166158
Lymph gland infection 14.42 10.08 19 563601 554 79180214
Chest pain 14.38 10.08 1761 561859 280543 78900225
Hypernatraemia 14.37 10.08 53 563567 14398 79166370
Pneumonia bacterial 14.35 10.08 79 563541 19252 79161516
Drug screen positive 14.35 10.08 13 563607 6050 79174718
Dry eye 14.29 10.08 352 563268 36579 79144189
Product administered to patient of inappropriate age 14.26 10.08 11 563609 5542 79175226
Lower respiratory tract congestion 14.21 10.08 61 563559 3936 79176832
Paranoia 14.11 10.08 80 563540 19352 79161416
Anticholinergic syndrome 14.11 10.08 4 563616 3607 79177161
Red blood cell count decreased 14.07 10.08 518 563102 56995 79123773
Anal fissure 14.05 10.08 98 563522 7605 79173163
Renal disorder 14.04 10.08 211 563409 41894 79138874
Tooth disorder 14.01 10.08 262 563358 25971 79154797
Upper respiratory tract infection 13.96 10.08 783 562837 90385 79090383
Hydrocephalus 13.93 10.08 26 563594 8874 79171894
Diabetes insipidus 13.93 10.08 10 563610 5227 79175541
Psychomotor skills impaired 13.93 10.08 10 563610 5227 79175541
Foetal exposure during pregnancy 13.89 10.08 79 563541 5711 79175057
Dactylitis 13.87 10.08 47 563573 2710 79178058
Incorrect route of product administration 13.83 10.08 169 563451 34760 79146008
Transaminases increased 13.80 10.08 270 563350 51473 79129295
Osteoporotic fracture 13.78 10.08 63 563557 4177 79176591
Joint lock 13.68 10.08 52 563568 3173 79177595
Tuberculin test positive 13.68 10.08 54 563566 3354 79177414
Type I hypersensitivity 13.65 10.08 7 563613 4391 79176377
Salivary hypersecretion 13.61 10.08 53 563567 14171 79166597
Spinal osteoarthritis 13.58 10.08 181 563439 16746 79164022
Dry skin 13.58 10.08 371 563249 67624 79113144
Persecutory delusion 13.55 10.08 9 563611 4900 79175868
Bone density abnormal 13.53 10.08 50 563570 3010 79177758
Hypoaesthesia 13.52 10.08 1457 562163 177895 79002873
Complications of transplanted kidney 13.52 10.08 15 563605 6351 79174417
Systemic inflammatory response syndrome 13.51 10.08 39 563581 11426 79169342
Lymphatic fistula 13.48 10.08 22 563598 781 79179987
Ileus paralytic 13.45 10.08 30 563590 9590 79171178
Feeling abnormal 13.44 10.08 956 562664 158243 79022525
Toxic encephalopathy 13.42 10.08 39 563581 11401 79169367
Immunosuppression 13.39 10.08 144 563476 12659 79168109
Atrioventricular block complete 13.39 10.08 66 563554 16544 79164224
Wound infection pseudomonas 13.37 10.08 33 563587 1588 79179180
Human herpesvirus 6 infection 13.33 10.08 11 563609 5359 79175409
Hyperpyrexia 13.33 10.08 14 563606 6078 79174690
Hypertonia 13.31 10.08 19 563601 7213 79173555
Intracranial pressure increased 13.31 10.08 24 563596 8298 79172470
Hypoventilation 13.28 10.08 19 563601 7205 79173563
Gastric cancer 13.23 10.08 33 563587 10146 79170622
Subarachnoid haemorrhage 13.16 10.08 110 563510 24355 79156413
Pulmonary tuberculosis 13.16 10.08 98 563522 7767 79173001
Coronary arterial stent insertion 13.10 10.08 14 563606 6030 79174738
Toothache 13.04 10.08 206 563414 19764 79161004
Clear cell renal cell carcinoma 13.03 10.08 44 563576 2532 79178236
Ligament rupture 13.00 10.08 53 563567 3341 79177427
Renal tubular disorder 13.00 10.08 16 563604 6470 79174298
C-reactive protein decreased 13.00 10.08 45 563575 2623 79178145
Walking aid user 12.98 10.08 119 563501 10029 79170739
Drug dose omission by device 12.97 10.08 15 563605 6235 79174533
Palmoplantar keratoderma 12.97 10.08 5 563615 3711 79177057
Haemorrhage in pregnancy 12.97 10.08 30 563590 1384 79179384
Laryngospasm 12.96 10.08 6 563614 3991 79176777
Vascular purpura 12.93 10.08 3 563617 3095 79177673
Cellulitis 12.91 10.08 916 562704 108144 79072624
Hypothyroidism 12.90 10.08 277 563343 52115 79128653
Hypophosphataemia 12.88 10.08 85 563535 19828 79160940
Tooth abscess 12.87 10.08 173 563447 16037 79164731
Skin neoplasm excision 12.79 10.08 25 563595 1025 79179743
Acute myeloid leukaemia recurrent 12.76 10.08 4 563616 3379 79177389
Metastasis 12.74 10.08 18 563602 6862 79173906
Abortion incomplete 12.73 10.08 3 563617 3061 79177707
Femoral hernia incarcerated 12.72 10.08 22 563598 820 79179948
Myopathy 12.69 10.08 89 563531 20474 79160294
Reversible cerebral vasoconstriction syndrome 12.68 10.08 3 563617 3054 79177714
Injection site extravasation 12.68 10.08 114 563506 9555 79171213
Carotid artery thrombosis 12.66 10.08 3 563617 3050 79177718
C-reactive protein 12.65 10.08 69 563551 4910 79175858
Tooth infection 12.57 10.08 195 563425 18637 79162131
Angina unstable 12.57 10.08 67 563553 16460 79164308
Cervical incompetence 12.54 10.08 17 563603 510 79180258
Cell death 12.46 10.08 9 563611 4690 79176078
Hyperlipidaemia 12.43 10.08 121 563499 25972 79154796
Oligoarthritis 12.38 10.08 20 563600 704 79180064
Sensitisation 12.34 10.08 4 563616 3307 79177461
Myofascial pain syndrome 12.32 10.08 37 563583 2000 79178768
Metastases to meninges 12.32 10.08 5 563615 3596 79177172
Small for dates baby 12.31 10.08 16 563604 460 79180308
Blood folate increased 12.31 10.08 17 563603 519 79180249
Nightmare 12.29 10.08 120 563500 25741 79155027
Joint warmth 12.29 10.08 32 563588 1592 79179176
Visual acuity reduced 12.28 10.08 141 563479 29328 79151440
Muscle spasticity 12.27 10.08 95 563525 21380 79159388
Pulmonary function test abnormal 12.27 10.08 7 563613 4137 79176631
Breast abscess 12.26 10.08 30 563590 1436 79179332
Human anti-human antibody test 12.18 10.08 15 563605 408 79180360
Immune effector cell-associated neurotoxicity syndrome 12.18 10.08 14 563606 5834 79174934
Generalised oedema 12.13 10.08 108 563512 23601 79157167
Abortion threatened 12.13 10.08 15 563605 410 79180358
Osteonecrosis 12.11 10.08 151 563469 30944 79149824
Drug hypersensitivity 12.10 10.08 1891 561729 297025 78883743
Alcohol interaction 12.08 10.08 10 563610 4864 79175904
Lip blister 12.06 10.08 45 563575 2722 79178046
Generalised tonic-clonic seizure 12.05 10.08 228 563392 43682 79137086
Cyst rupture 12.05 10.08 19 563601 655 79180113
Hepatitis E antibody positive 12.05 10.08 12 563608 256 79180512
Therapy non-responder 11.93 10.08 781 562839 91524 79089244
Bacterial sepsis 11.93 10.08 25 563595 8173 79172595
Epstein-Barr virus associated lymphoproliferative disorder 11.92 10.08 5 563615 3527 79177241
Accidental exposure to product by child 11.89 10.08 3 563617 2923 79177845
Anal fistula 11.89 10.08 87 563533 6857 79173911
Drug abuser 11.88 10.08 15 563605 5998 79174770
Hyperthermia malignant 11.84 10.08 3 563617 2914 79177854
Steroid diabetes 11.78 10.08 5 563615 3501 79177267
Neurologic neglect syndrome 11.77 10.08 3 563617 2904 79177864
Nephrotic syndrome 11.77 10.08 40 563580 11134 79169634
Peritoneal dialysis complication 11.73 10.08 40 563580 2314 79178454
Threatened labour 11.73 10.08 18 563602 606 79180162
Joint ankylosis 11.71 10.08 38 563582 2142 79178626
Hypocalcaemia 11.70 10.08 266 563354 49658 79131110
Drug specific antibody 11.67 10.08 43 563577 2585 79178183
Spondylitis 11.64 10.08 65 563555 4666 79176102
Nail injury 11.64 10.08 18 563602 610 79180158
Placental insufficiency 11.62 10.08 25 563595 1098 79179670
Oesophageal fibrosis 11.61 10.08 10 563610 176 79180592
Incoherent 11.58 10.08 23 563597 7669 79173099
Defaecation disorder 11.49 10.08 19 563601 682 79180086
Respiratory tract infection viral 11.49 10.08 60 563560 4199 79176569
Pneumonia aspiration 11.48 10.08 373 563247 66594 79114174
Depressed mood 11.45 10.08 258 563362 48222 79132546
Starvation ketoacidosis 11.42 10.08 9 563611 139 79180629
Renal cancer 11.41 10.08 46 563574 12180 79168588
Diplopia 11.41 10.08 167 563453 33299 79147469
Left ventricular dysfunction 11.37 10.08 85 563535 19276 79161492
Vascular device infection 11.36 10.08 36 563584 10240 79170528
Skin injury 11.36 10.08 51 563569 3355 79177413
Ventricular hypokinesia 11.36 10.08 31 563589 9248 79171520
Road traffic accident 11.35 10.08 396 563224 43268 79137500
Aphthous ulcer 11.32 10.08 175 563445 16714 79164054
Psychiatric decompensation 11.30 10.08 7 563613 3956 79176812
Tooth fracture 11.29 10.08 128 563492 11402 79169366
Aplasia 11.25 10.08 24 563596 7796 79172972
Gestational hypertension 11.24 10.08 34 563586 1845 79178923
Panic attack 11.24 10.08 113 563507 24103 79156665
Anger 11.23 10.08 73 563547 17089 79163679
Chills 11.22 10.08 977 562643 159257 79021511
Acute pulmonary oedema 11.21 10.08 57 563563 14173 79166595
Lung opacity 11.20 10.08 12 563608 5162 79175606
Mitochondrial toxicity 11.19 10.08 4 563616 3110 79177658
Arthropod bite 11.17 10.08 100 563520 8371 79172397
Renal tubular necrosis 11.15 10.08 118 563502 24921 79155847
Acute lung injury 11.11 10.08 4 563616 3096 79177672
Rash erythematous 11.08 10.08 317 563303 57452 79123316
Pseudomembranous colitis 11.05 10.08 13 563607 5361 79175407
Iodine allergy 11.04 10.08 17 563603 574 79180194
Spinal disorder 11.01 10.08 116 563504 10144 79170624
Genital haemorrhage 10.96 10.08 17 563603 6238 79174530
Candida infection 10.93 10.08 197 563423 38017 79142751
Adverse drug reaction 10.92 10.08 574 563046 65818 79114950
Complication of device removal 10.91 10.08 7 563613 3882 79176886
Sarcopenia 10.91 10.08 15 563605 456 79180312
Delusion 10.91 10.08 92 563528 20331 79160437
Benign ovarian tumour 10.90 10.08 13 563607 342 79180426
Inadequate analgesia 10.86 10.08 10 563610 4619 79176149
Hepatitis B 10.84 10.08 27 563593 8305 79172463
Proctitis 10.79 10.08 18 563602 6414 79174354
Hypercholesterolaemia 10.77 10.08 226 563394 22869 79157899
Pleural fibrosis 10.76 10.08 58 563562 4109 79176659
Cardiomyopathy 10.73 10.08 141 563479 28633 79152135
Product monitoring error 10.72 10.08 30 563590 8876 79171892
Hernia pain 10.71 10.08 15 563605 464 79180304
Pulmonary pain 10.71 10.08 61 563559 4412 79176356
Bronchial secretion retention 10.70 10.08 8 563612 4096 79176672
Eyelid oedema 10.68 10.08 55 563565 13632 79167136
Skin exfoliation 10.65 10.08 302 563318 54798 79125970
Eye infection 10.64 10.08 130 563490 11790 79168978
Foetal death 10.63 10.08 95 563525 7949 79172819
Mass 10.57 10.08 178 563442 17294 79163474
Lung transplant 10.53 10.08 10 563610 4551 79176217
Neutropenic colitis 10.50 10.08 15 563605 5692 79175076
Arthritis bacterial 10.49 10.08 105 563515 9061 79171707
Complication of device insertion 10.44 10.08 18 563602 6332 79174436
Serum ferritin increased 10.41 10.08 111 563509 9736 79171032
Bone density increased 10.41 10.08 20 563600 809 79179959
Presyncope 10.41 10.08 216 563404 40838 79139930
Colitis microscopic 10.38 10.08 40 563580 10728 79170040
Dermatitis allergic 10.36 10.08 183 563437 17947 79162821
Upper respiratory tract inflammation 10.35 10.08 8 563612 4027 79176741
Skin ulcer haemorrhage 10.31 10.08 16 563604 544 79180224
Cirrhosis alcoholic 10.31 10.08 23 563597 1036 79179732
Cartilage injury 10.27 10.08 29 563591 1514 79179254
Paresis 10.25 10.08 9 563611 4252 79176516
Device occlusion 10.24 10.08 46 563574 11820 79168948
Intestinal stenosis 10.21 10.08 53 563567 3701 79177067
Cryptococcosis 10.20 10.08 6 563614 3487 79177281
Pancreatic steatosis 10.18 10.08 24 563596 1121 79179647
Vacuum extractor delivery 10.18 10.08 8 563612 123 79180645
Cholestasis of pregnancy 10.15 10.08 22 563598 971 79179797
Paraesthesia oral 10.15 10.08 94 563526 20377 79160391
CD4 lymphocytes decreased 10.14 10.08 3 563617 2631 79178137
Hypogammaglobulinaemia 10.13 10.08 52 563568 12899 79167869
Stress at work 10.10 10.08 24 563596 1127 79179641
Hand fracture 10.09 10.08 77 563543 6148 79174620

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11DA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12
Vitamin B1, plain
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:71692 insect repellents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Korsakoff's psychosis indication 69482004 DOID:10915
Pernicious anemia indication 84027009 DOID:13381
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Cobalamin deficiency indication 190634004
Thiamin deficiency indication 399357009 DOID:0070313
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Prevention of Vitamin B12 Deficiency indication
Methylmalonic acidemia off-label use 42393006
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Agoraphobia contraindication 70691001 DOID:593
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Panic disorder contraindication 371631005 DOID:594
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thiamine transporter 1 Transporter WOMBAT-PK
Transketolase Enzyme WOMBAT-PK
Thiamin pyrophosphokinase 1 Kinase WOMBAT-PK
Thiamine-triphosphatase Enzyme WOMBAT-PK
Transketolase-like protein 1 Enzyme WOMBAT-PK
Heat shock protein HSP 90-alpha Cytosolic other IC50 4.90 CHEMBL
Thiamine transporter ThiT Transporter Kd 9.91 CHEMBL

External reference:

IDSource
4017777 VUID
N0000146138 NUI
D08580 KEGG_DRUG
67-03-8 SECONDARY_CAS_RN
532-43-4 SECONDARY_CAS_RN
4017446 VANDF
4017474 VANDF
4017634 VANDF
4017777 VANDF
4021900 VANDF
C0039840 UMLSCUI
CHEBI:26948 CHEBI
VIB PDB_CHEM_ID
CHEMBL1547 ChEMBL_ID
CHEMBL1588 ChEMBL_ID
CHEMBL1200941 ChEMBL_ID
DB00152 DRUGBANK_ID
CHEMBL2104496 ChEMBL_ID
D013831 MESH_DESCRIPTOR_UI
C000712172 MESH_SUPPLEMENTAL_RECORD_UI
1130 PUBCHEM_CID
4629 IUPHAR_LIGAND_ID
432 INN_ID
X66NSO3N35 UNII
10454 RXNORM
1096 MMSL
15466 MMSL
41397 MMSL
5566 MMSL
5681 MMSL
7276 MMSL
d03130 MMSL
001061 NDDF
001062 NDDF
003860 NDDF
126228004 SNOMEDCT_US
126229007 SNOMEDCT_US
259659006 SNOMEDCT_US
30306003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 2 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 4.54 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 4.54 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 3 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 3 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 3 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 3 mg ORAL Unapproved drug other 11 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9963 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 11 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9963 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 11 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9963 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 11 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9963 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 11 sections
Thiamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0641-6228 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 15 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1.60 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1.10 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1.60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.60 mg ORAL Unapproved drug other 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.60 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 20 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 20 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1.60 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 3 mg ORAL UNAPPROVED DRUG OTHER 4 sections