thiamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2832 59-43-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiamine
  • vitamin B1
  • thiamine hydrochloride
  • thiamine mononitrate
  • thiamine (vit B1)
  • thiamine HCl
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.
  • Molecular weight: 265.35
  • Formula: C12H17N4OS
  • CLOGP: -5.67
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.91
  • ALOGS: -4.29
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O
50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 27 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.55 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 4.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1993 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1758.45 10.05 3873 444760 153339 55690095
Rheumatoid arthritis 1665.69 10.05 6734 441899 375870 55467564
Systemic lupus erythematosus 1636.36 10.05 4090 444543 175988 55667446
Glossodynia 1459.06 10.05 3533 445100 148925 55694509
Hand deformity 1183.36 10.05 3019 445614 131473 55711961
Arthropathy 1090.78 10.05 3792 444841 196483 55646951
Alopecia 1025.13 10.05 4839 443794 288619 55554815
Abdominal discomfort 1013.96 10.05 4634 443999 272640 55570794
Wound 981.59 10.05 2876 445757 135928 55707506
Maternal exposure during pregnancy 951.59 10.05 3495 445138 186058 55657376
Synovitis 790.63 10.05 2952 445681 158353 55685081
Completed suicide 780.48 10.05 80 448553 133753 55709681
Pericarditis 766.93 10.05 2254 446379 106669 55736765
Anti-cyclic citrullinated peptide antibody positive 751.00 10.05 2099 446534 96501 55746933
Infusion related reaction 737.06 10.05 3457 445176 205474 55637960
Discomfort 733.02 10.05 2640 445993 139121 55704313
Contraindicated product administered 723.97 10.05 3172 445461 183114 55660320
Swelling 702.38 10.05 3764 444869 236007 55607427
Joint swelling 675.41 10.05 4282 444351 285518 55557916
Toxicity to various agents 609.23 10.05 536 448097 224028 55619406
Pain 577.66 10.05 7923 440710 655261 55188173
Death 532.23 10.05 1211 447422 340215 55503219
Product use issue 468.60 10.05 2806 445827 183235 55660199
Duodenal ulcer perforation 464.32 10.05 1397 447236 66945 55776489
Helicobacter infection 450.87 10.05 1447 447186 71821 55771613
Rheumatoid factor positive 450.78 10.05 1392 447241 67668 55775766
Hepatic enzyme increased 419.48 10.05 2566 446067 168818 55674616
Arthralgia 387.47 10.05 5873 442760 495796 55347638
Drug interaction 359.04 10.05 705 447928 209050 55634384
Drug abuse 356.31 10.05 56 448577 67554 55775880
Intentional overdose 348.79 10.05 61 448572 68056 55775378
Therapeutic product effect decreased 325.97 10.05 2390 446243 167062 55676372
Drug intolerance 320.32 10.05 3372 445261 261446 55581988
Musculoskeletal stiffness 306.72 10.05 2212 446421 153795 55689639
Exposure during pregnancy 302.83 10.05 1992 446641 134350 55709084
Treatment failure 291.83 10.05 2339 446294 168053 55675381
Febrile neutropenia 259.07 10.05 275 448358 105270 55738164
Hip arthroplasty 249.59 10.05 776 447857 37847 55805587
Knee arthroplasty 234.95 10.05 832 447801 43427 55800007
Psoriatic arthropathy 231.26 10.05 1184 447449 72824 55770610
Hypersensitivity 225.85 10.05 3074 445559 253334 55590100
Suicide attempt 216.05 10.05 95 448538 57741 55785693
Depressed level of consciousness 207.19 10.05 95 448538 56338 55787096
Acute kidney injury 203.09 10.05 1108 447525 239655 55603779
Overdose 202.19 10.05 332 448301 105498 55737936
Nasopharyngitis 198.60 10.05 2659 445974 218300 55625134
Constipation 195.75 10.05 885 447748 201058 55642376
Impaired healing 195.25 10.05 1273 447360 85568 55757866
Malignant neoplasm progression 192.87 10.05 181 448452 73406 55770028
Rheumatic fever 189.79 10.05 583 448050 28244 55815190
Disease progression 185.44 10.05 347 448286 104826 55738608
Cardiac arrest 181.05 10.05 254 448379 86060 55757374
Nausea 178.24 10.05 4686 443947 759492 55083942
Diarrhoea 174.47 10.05 3822 444811 634685 55208749
Device expulsion 172.81 10.05 20 448613 30429 55813005
Red blood cell sedimentation rate abnormal 171.99 10.05 427 448206 18246 55825188
Swollen joint count increased 170.43 10.05 501 448132 23683 55819751
Neutropenia 169.39 10.05 667 447966 157500 55685934
Muscle injury 156.43 10.05 829 447804 51671 55791763
Folliculitis 155.60 10.05 856 447777 54123 55789311
Blister 155.41 10.05 1436 447197 107451 55735983
Sedation 149.12 10.05 46 448587 34808 55808626
Sleep disorder due to general medical condition, insomnia type 146.43 10.05 709 447924 42629 55800805
Anxiety 146.29 10.05 920 447713 192252 55651182
Hypotension 145.84 10.05 1285 447348 249223 55594211
C-reactive protein abnormal 145.01 10.05 630 448003 36179 55807255
Asthenia 142.43 10.05 1902 446731 341071 55502363
Cardiac failure 141.94 10.05 274 448359 81819 55761615
Lactic acidosis 138.56 10.05 54 448579 35292 55808142
Bradycardia 136.29 10.05 204 448429 67300 55776134
Drug hypersensitivity 132.48 10.05 1478 447155 273727 55569707
Somnolence 130.66 10.05 765 447868 162648 55680786
Sickle cell anaemia with crisis 130.51 10.05 180 448453 4848 55838586
Tremor 129.38 10.05 511 448122 120578 55722856
Lower respiratory tract infection 127.47 10.05 1438 447195 113356 55730078
Irritable bowel syndrome 125.43 10.05 955 447678 67503 55775931
Drug ineffective 123.98 10.05 8700 439933 910289 54933145
Dyspnoea 121.39 10.05 3698 444935 588879 55254555
Rash 121.20 10.05 4940 443693 488107 55355327
Vomiting 120.29 10.05 3038 445595 495190 55348244
Renal failure 120.17 10.05 463 448170 110037 55733397
Pregnancy 117.84 10.05 549 448084 32484 55810950
Fatigue 114.45 10.05 7512 441121 781040 55062394
Asthma 113.53 10.05 487 448146 112283 55731151
Agitation 108.66 10.05 174 448459 55862 55787572
Respiratory arrest 108.66 10.05 54 448579 30571 55812863
Osteoarthritis 108.58 10.05 1047 447586 79249 55764185
Dizziness 107.75 10.05 2233 446400 373907 55469527
Intentional self-injury 106.89 10.05 33 448600 24959 55818475
Neoplasm progression 105.49 10.05 62 448571 31954 55811480
Syncope 104.84 10.05 474 448159 107725 55735709
Multiple sclerosis relapse 104.64 10.05 122 448511 44781 55798653
Sopor 104.35 10.05 20 448613 20902 55822532
Rhabdomyolysis 104.19 10.05 102 448531 40556 55802878
Hyponatraemia 104.10 10.05 439 448194 101700 55741734
Condition aggravated 102.72 10.05 3531 445102 341367 55502067
Drug reaction with eosinophilia and systemic symptoms 100.82 10.05 58 448575 30246 55813188
Arthritis 100.28 10.05 1227 447406 98625 55744809
Hyperhidrosis 98.63 10.05 400 448233 93688 55749746
Electrocardiogram QT prolonged 98.05 10.05 178 448455 54410 55789024
Neuropathy peripheral 97.76 10.05 454 448179 102439 55740995
Blood cholesterol increased 93.06 10.05 936 447697 71643 55771791
Live birth 91.00 10.05 353 448280 19252 55824182
Myalgia 90.75 10.05 647 447986 131378 55712056
Cardio-respiratory arrest 88.52 10.05 193 448440 55128 55788306
Drug dependence 87.37 10.05 35 448598 22498 55820936
Tachycardia 87.08 10.05 491 448142 105385 55738049
Cognitive disorder 85.78 10.05 163 448470 48970 55794464
Product quality issue 85.58 10.05 76 448557 31660 55811774
Drug withdrawal syndrome 85.29 10.05 50 448583 25807 55817627
Pulmonary arterial hypertension 84.97 10.05 53 448580 26450 55816984
Type 2 diabetes mellitus 84.85 10.05 652 447981 46210 55797224
Hypoglycaemia 82.65 10.05 203 448430 55612 55787822
Hypoxia 82.20 10.05 193 448440 53704 55789730
Serotonin syndrome 82.17 10.05 55 448578 26435 55816999
Abortion spontaneous 81.60 10.05 613 448020 43140 55800294
Plasma cell myeloma 81.21 10.05 155 448478 46491 55796943
Sedation complication 79.73 10.05 3 448630 11669 55831765
Cardiac failure congestive 79.27 10.05 394 448239 87326 55756108
Anaemia 78.61 10.05 1581 447052 265930 55577504
Ill-defined disorder 77.58 10.05 862 447771 67681 55775753
Hyperglycaemia 76.96 10.05 116 448517 38165 55805269
Insomnia 76.25 10.05 1073 447560 190787 55652647
Renal impairment 76.15 10.05 357 448276 80356 55763078
Orthostatic hypotension 75.43 10.05 92 448541 33107 55810327
Blood pressure fluctuation 75.01 10.05 565 448068 39795 55803639
Thrombocytopenia 73.87 10.05 711 447922 135513 55707921
Peripheral swelling 73.56 10.05 2418 446215 232308 55611126
Liver injury 71.77 10.05 575 448058 41273 55802161
Drug resistance 71.71 10.05 37 448596 20505 55822929
Foot deformity 71.49 10.05 377 448256 23448 55819986
No adverse event 71.41 10.05 112 448521 36262 55807172
Feeling abnormal 70.90 10.05 701 447932 132901 55710533
Seizure 70.86 10.05 646 447987 124473 55718961
Chest discomfort 70.61 10.05 479 448154 98378 55745056
Joint effusion 70.58 10.05 270 448363 14628 55828806
Palmar-plantar erythrodysaesthesia syndrome 70.53 10.05 40 448593 21025 55822409
Contusion 69.92 10.05 1424 447209 127006 55716428
Respiratory failure 69.20 10.05 458 448175 94604 55748830
Fibromyalgia 69.02 10.05 753 447880 58850 55784584
Balance disorder 68.96 10.05 344 448289 76176 55767258
Depression 68.87 10.05 1015 447618 179102 55664332
Sinusitis 68.64 10.05 2061 446572 195520 55647914
Red blood cell sedimentation rate increased 68.24 10.05 513 448120 36110 55807324
Dehydration 67.15 10.05 877 447756 157948 55685486
Pulmonary embolism 66.50 10.05 540 448093 106584 55736850
Intentional product use issue 66.10 10.05 1140 447493 98593 55744841
Vision blurred 65.86 10.05 389 448244 82554 55760880
Multiple organ dysfunction syndrome 65.47 10.05 209 448424 52561 55790873
Hepatic function abnormal 65.41 10.05 109 448524 34449 55808985
Coma 64.16 10.05 251 448382 59404 55784030
Neutrophil count decreased 62.74 10.05 196 448437 49626 55793808
Hepatic failure 62.11 10.05 107 448526 33379 55810055
Metabolic acidosis 61.58 10.05 145 448488 40309 55803125
Injection site erythema 61.37 10.05 912 447721 76536 55766898
Creatinine renal clearance decreased 60.88 10.05 20 448613 14539 55828895
Urticaria 60.74 10.05 800 447833 143876 55699558
Disability assessment scale score increased 60.62 10.05 91 448542 2653 55840781
Infection 60.55 10.05 2054 446579 198152 55645282
Blood glucose increased 60.44 10.05 351 448282 74800 55768634
Metastases to bone 59.84 10.05 41 448592 19467 55823967
Fluid retention 59.79 10.05 225 448408 53853 55789581
Intentional product misuse 59.78 10.05 210 448423 51294 55792140
Cholestasis 59.66 10.05 76 448557 26837 55816597
Blood pressure diastolic abnormal 58.94 10.05 215 448418 11383 55832051
Encephalopathy 58.38 10.05 121 448512 35204 55808230
Diabetic ketoacidosis 57.44 10.05 40 448593 18831 55824603
Basal cell carcinoma 57.41 10.05 371 448262 24850 55818584
Cytomegalovirus infection 57.29 10.05 42 448591 19254 55824180
Bone erosion 57.22 10.05 254 448379 14720 55828714
Grip strength decreased 57.11 10.05 269 448364 15987 55827447
Hepatocellular injury 56.60 10.05 77 448556 26437 55816997
Altered state of consciousness 56.43 10.05 60 448573 22961 55820473
Loss of consciousness 56.24 10.05 578 448055 108771 55734663
White blood cell count decreased 56.11 10.05 688 447945 125302 55718132
Osteoporosis 55.91 10.05 648 447985 51404 55792030
Ejection fraction decreased 55.34 10.05 46 448587 19795 55823639
Leukopenia 55.11 10.05 335 448298 70605 55772829
Muscle spasticity 54.79 10.05 47 448586 19913 55823521
Muscle spasms 54.64 10.05 768 447865 136603 55706831
Mydriasis 54.34 10.05 11 448622 11060 55832374
Caesarean section 54.16 10.05 263 448370 15828 55827606
Joint laxity 54.05 10.05 81 448552 2358 55841076
Hallucination 54.01 10.05 205 448428 48944 55794490
Injection site pruritus 53.37 10.05 540 448093 41391 55802043
Hyperkalaemia 52.81 10.05 217 448416 50648 55792786
Mental status changes 52.73 10.05 140 448493 37361 55806073
Weight increased 52.45 10.05 2285 446348 227418 55616016
Blood pressure decreased 52.33 10.05 267 448366 58783 55784651
Blood pressure systolic abnormal 52.04 10.05 184 448449 9593 55833841
Osteonecrosis of jaw 52.03 10.05 118 448515 33240 55810194
Emotional distress 51.72 10.05 99 448534 29664 55813770
Disturbance in attention 51.66 10.05 114 448519 32426 55811008
Macular degeneration 51.32 10.05 45 448588 18863 55824571
Blood pressure systolic increased 51.07 10.05 524 448109 40312 55803122
Platelet count decreased 50.81 10.05 572 448061 105811 55737623
Blood calcium decreased 50.76 10.05 69 448564 23700 55819734
Loss of personal independence in daily activities 50.67 10.05 921 447712 80448 55762986
Anaphylactic reaction 50.46 10.05 270 448363 58725 55784709
Premature labour 50.38 10.05 208 448425 11674 55831760
Product use in unapproved indication 50.25 10.05 804 447829 140018 55703416
Decreased appetite 50.24 10.05 1346 447287 217885 55625549
Respiratory disorder 49.88 10.05 124 448509 33833 55809601
Deep vein thrombosis 49.17 10.05 385 448248 76592 55766842
Hypothermia 48.95 10.05 19 448614 12451 55830983
Pain in jaw 48.66 10.05 160 448473 39876 55803558
Hypokalaemia 48.63 10.05 499 448134 93938 55749496
Dyspnoea exertional 48.62 10.05 247 448386 54442 55788992
Suicidal ideation 48.43 10.05 266 448367 57476 55785958
Restlessness 48.36 10.05 86 448547 26500 55816934
Foetal exposure during pregnancy 48.17 10.05 446 448187 33377 55810057
Angioedema 48.12 10.05 169 448464 41284 55802150
Poisoning 47.91 10.05 21 448612 12792 55830642
Myocardial infarction 47.71 10.05 491 448142 92379 55751055
Flushing 46.95 10.05 346 448287 69754 55773680
Extrapyramidal disorder 46.60 10.05 20 448613 12336 55831098
Multiple fractures 46.03 10.05 146 448487 7195 55836239
Blood creatine phosphokinase increased 45.98 10.05 96 448537 27856 55815578
Stomatitis 45.71 10.05 1274 447359 119536 55723898
Palpitations 45.62 10.05 541 448092 99131 55744303
Shock 45.48 10.05 64 448569 21664 55821770
Aspartate aminotransferase increased 45.24 10.05 430 448203 82172 55761262
Dysphagia 45.13 10.05 426 448207 81521 55761913
Drug ineffective for unapproved indication 45.05 10.05 85 448548 25608 55817826
Bone pain 44.99 10.05 226 448407 49959 55793475
Injection site reaction 44.94 10.05 634 447999 52613 55790821
Metastases to liver 44.76 10.05 64 448569 21522 55821912
Pulmonary fibrosis 44.72 10.05 397 448236 29361 55814073
Product administration error 44.45 10.05 61 448572 20868 55822566
Dysgeusia 44.09 10.05 172 448461 40743 55802691
Cerebral haemorrhage 43.96 10.05 102 448531 28504 55814930
Atrial fibrillation 43.58 10.05 608 448025 108289 55735145
Anaphylactic shock 43.58 10.05 66 448567 21674 55821760
Wrong technique in product usage process 43.46 10.05 278 448355 57890 55785544
Unresponsive to stimuli 43.43 10.05 120 448513 31605 55811829
Speech disorder 43.42 10.05 153 448480 37340 55806094
Pulmonary oedema 43.22 10.05 235 448398 50908 55792526
Schizophrenia 42.90 10.05 15 448618 10484 55832950
Hospitalisation 42.55 10.05 387 448246 74613 55768821
Joint range of motion decreased 42.12 10.05 346 448287 25019 55818415
C-reactive protein increased 42.00 10.05 870 447763 77814 55765620
Blood alkaline phosphatase increased 41.78 10.05 164 448469 38781 55804653
Ascites 41.63 10.05 156 448477 37388 55806046
Drug tolerance decreased 41.46 10.05 214 448419 13197 55830237
Neck deformity 41.46 10.05 65 448568 1970 55841464
Inflammation 41.33 10.05 777 447856 68294 55775140
Torsade de pointes 41.11 10.05 24 448609 12416 55831018
Respiratory depression 41.08 10.05 24 448609 12411 55831023
Pleural effusion 40.66 10.05 460 448173 85020 55758414
Gestational diabetes 40.57 10.05 149 448484 7915 55835519
COVID-19 40.56 10.05 392 448241 74666 55768768
Drug level increased 40.51 10.05 64 448569 20661 55822773
Device dislocation 40.33 10.05 74 448559 22532 55820902
Disability 40.23 10.05 239 448394 15541 55827893
Abnormal behaviour 40.19 10.05 62 448571 20210 55823224
Disseminated intravascular coagulation 40.17 10.05 50 448583 17835 55825599
Memory impairment 39.93 10.05 469 448164 86088 55757346
Joint destruction 39.78 10.05 109 448524 4946 55838488
Maternal exposure before pregnancy 39.45 10.05 132 448501 6691 55836743
Disorientation 39.40 10.05 154 448479 36459 55806975
Blood bilirubin increased 39.37 10.05 135 448498 33219 55810215
Chest pain 39.22 10.05 1182 447451 188615 55654819
Vertigo 39.16 10.05 264 448369 54308 55789126
Rheumatoid nodule 39.16 10.05 227 448406 14630 55828804
Chronic kidney disease 39.08 10.05 187 448446 41869 55801565
Blood pressure diastolic decreased 39.05 10.05 276 448357 19047 55824387
Gamma-glutamyltransferase increased 39.01 10.05 122 448511 30883 55812551
Cerebrovascular accident 38.75 10.05 557 448076 98713 55744721
Acute hepatic failure 38.66 10.05 45 448588 16533 55826901
Maternal drugs affecting foetus 38.29 10.05 108 448525 4985 55838449
Pulmonary hypertension 38.16 10.05 152 448481 35792 55807642
Alanine aminotransferase increased 37.81 10.05 522 448111 93140 55750294
Akathisia 37.77 10.05 11 448622 8641 55834793
Multiple sclerosis 37.43 10.05 106 448527 27696 55815738
Cytokine release syndrome 37.35 10.05 20 448613 10855 55832579
Sepsis 36.50 10.05 842 447791 138998 55704436
Injection site swelling 36.42 10.05 518 448115 43060 55800374
Infective pulmonary exacerbation of cystic fibrosis 36.29 10.05 10 448623 8147 55835287
Back pain 36.03 10.05 1534 447099 235636 55607798
Product dose omission issue 35.73 10.05 1303 447330 203450 55639984
Polyarthritis 35.61 10.05 151 448482 8577 55834857
Accidental overdose 35.60 10.05 68 448565 20393 55823041
Arrhythmia 35.59 10.05 151 448482 34932 55808502
Tuberculosis 35.51 10.05 178 448455 10851 55832583
Joint stiffness 35.39 10.05 435 448198 34990 55808444
Device difficult to use 35.22 10.05 21 448612 10740 55832694
Haemorrhage 34.66 10.05 285 448348 56112 55787322
Accidental exposure to product 34.66 10.05 92 448541 24555 55818879
Posterior reversible encephalopathy syndrome 34.42 10.05 46 448587 15914 55827520
Respiratory distress 34.20 10.05 133 448500 31534 55811900
International normalised ratio increased 34.19 10.05 208 448425 43833 55799601
Dysarthria 33.82 10.05 181 448452 39369 55804065
Withdrawal syndrome 33.32 10.05 60 448573 18402 55825032
Enthesopathy 33.29 10.05 140 448493 7923 55835511
Ventricular tachycardia 33.21 10.05 52 448581 16849 55826585
Brain oedema 33.19 10.05 34 448599 13237 55830197
Psychotic disorder 33.08 10.05 88 448545 23470 55819964
Melaena 33.06 10.05 115 448518 28175 55815259
Juvenile idiopathic arthritis 32.79 10.05 98 448535 4675 55838759
Gastrointestinal disorder 32.71 10.05 1151 447482 111551 55731883
Tenderness 32.44 10.05 273 448360 19882 55823552
Laryngitis 32.37 10.05 206 448427 13724 55829710
Joint dislocation 32.29 10.05 226 448407 15547 55827887
Mania 31.77 10.05 27 448606 11493 55831941
Limb deformity 31.67 10.05 85 448548 3810 55839624
Neurotoxicity 31.61 10.05 48 448585 15747 55827687
Lupus-like syndrome 31.54 10.05 188 448445 12239 55831195
Nodule 31.47 10.05 255 448378 18364 55825070
Ventricular septal defect 31.35 10.05 88 448545 4050 55839384
Thrombotic microangiopathy 31.32 10.05 18 448615 9393 55834041
Bronchospasm 30.99 10.05 48 448585 15621 55827813
Breast cancer metastatic 30.97 10.05 47 448586 15422 55828012
Dyskinesia 30.96 10.05 123 448510 28985 55814449
Polyneuropathy 30.89 10.05 35 448598 13015 55830419
Diabetes mellitus inadequate control 30.45 10.05 40 448593 13940 55829494
Irritability 30.23 10.05 127 448506 29461 55813973
Coagulopathy 30.18 10.05 65 448568 18651 55824783
Nightmare 30.09 10.05 55 448578 16771 55826663
Asphyxia 30.03 10.05 5 448628 5784 55837650
Acute respiratory failure 29.86 10.05 136 448497 30858 55812576
Eosinophilia 29.73 10.05 73 448560 20004 55823430
Obstructive airways disorder 29.58 10.05 58 448575 17224 55826210
Pancreatitis acute 29.44 10.05 102 448531 25022 55818412
Toxic skin eruption 29.44 10.05 30 448603 11709 55831725
Latent tuberculosis 29.42 10.05 63 448570 2439 55840995
Parkinsonism 29.36 10.05 20 448613 9526 55833908
Musculoskeletal pain 29.35 10.05 851 447782 80301 55763133
Disease recurrence 29.24 10.05 95 448538 23765 55819669
Stress cardiomyopathy 29.12 10.05 15 448618 8321 55835113
Acute myeloid leukaemia 29.01 10.05 57 448576 16915 55826519
Transplant rejection 29.00 10.05 22 448611 9912 55833522
Gastrointestinal haemorrhage 28.99 10.05 428 448205 75523 55767911
Pre-eclampsia 28.77 10.05 139 448494 8347 55835087
Psoriasis 28.75 10.05 954 447679 91738 55751696
Blood creatinine increased 28.54 10.05 458 448175 79733 55763701
Adverse event 28.47 10.05 609 448024 54767 55788667
Headache 28.43 10.05 3964 444669 555080 55288354
Localised infection 28.43 10.05 339 448294 27073 55816361
Delirium 28.39 10.05 210 448423 42307 55801127
Premature rupture of membranes 28.28 10.05 93 448540 4672 55838762
Crying 27.95 10.05 83 448550 21357 55822077
Haematotoxicity 27.95 10.05 16 448617 8367 55835067
Agranulocytosis 27.92 10.05 90 448543 22569 55820865
Second primary malignancy 27.89 10.05 12 448621 7390 55836044
Heart rate decreased 27.82 10.05 465 448168 39962 55803472
Injection site pain 27.80 10.05 1170 447463 115948 55727486
Femur fracture 27.79 10.05 454 448179 38841 55804593
Paralysis 27.68 10.05 19 448614 9013 55834421
Device use error 27.67 10.05 5 448628 5451 55837983
Small for dates baby 27.66 10.05 76 448557 3454 55839980
Tenosynovitis stenosans 27.55 10.05 63 448570 2551 55840883
Panic attack 27.50 10.05 78 448555 20369 55823065
Blood potassium decreased 27.29 10.05 188 448445 38484 55804950
Metastases to central nervous system 27.18 10.05 34 448599 12102 55831332
Abdominal pain 27.12 10.05 1738 446895 257067 55586367
Tenosynovitis 26.96 10.05 181 448452 12280 55831154
Atrioventricular block complete 26.91 10.05 13 448620 7481 55835953
Blood pressure diastolic increased 26.74 10.05 137 448496 8424 55835010
Complication of device insertion 26.55 10.05 9 448624 6415 55837019
Unevaluable event 26.21 10.05 248 448385 47439 55795995
Smear cervix abnormal 26.03 10.05 64 448569 2717 55840717
Hemiparesis 26.03 10.05 86 448547 21404 55822030
Hypomania 25.95 10.05 4 448629 4898 55838536
Ischaemic stroke 25.92 10.05 60 448573 16782 55826652
Stevens-Johnson syndrome 25.90 10.05 93 448540 22570 55820864
Injection site rash 25.87 10.05 227 448406 16731 55826703
Febrile bone marrow aplasia 25.82 10.05 10 448623 6562 55836872
Abdominal distension 25.77 10.05 449 448184 77177 55766257
Status epilepticus 25.75 10.05 51 448582 15090 55828344
Cytopenia 25.54 10.05 24 448609 9731 55833703
Graft versus host disease 25.53 10.05 11 448622 6770 55836664
Maternal exposure timing unspecified 25.45 10.05 98 448535 5325 55838109
Tachypnoea 25.37 10.05 53 448580 15377 55828057
Pyrexia 25.36 10.05 2936 445697 415837 55427597
Ventricular fibrillation 25.25 10.05 30 448603 10922 55832512
Face oedema 25.10 10.05 70 448563 18382 55825052
Metastases to lung 25.04 10.05 34 448599 11684 55831750
Injection site bruising 25.03 10.05 439 448194 38082 55805352
Wheelchair user 25.02 10.05 98 448535 5368 55838066
Complication associated with device 25.01 10.05 53 448580 15297 55828137
Neuroleptic malignant syndrome 24.83 10.05 33 448600 11445 55831989
Myelosuppression 24.66 10.05 65 448568 17390 55826044
Inappropriate antidiuretic hormone secretion 24.57 10.05 45 448588 13711 55829723
Genital haemorrhage 24.49 10.05 12 448621 6850 55836584
Erythema multiforme 24.44 10.05 24 448609 9530 55833904
Synovial cyst 24.42 10.05 141 448492 9073 55834361
Miosis 24.34 10.05 11 448622 6581 55836853
Arthritis infective 24.26 10.05 103 448530 5853 55837581
Glycosylated haemoglobin increased 24.26 10.05 32 448601 11133 55832301
Dry skin 24.21 10.05 249 448384 46860 55796574
Anhedonia 24.12 10.05 26 448607 9888 55833546
Depressed mood 24.08 10.05 180 448453 36179 55807255
Dysmorphism 24.06 10.05 54 448579 2159 55841275
Tumour lysis syndrome 23.84 10.05 17 448616 7906 55835528
Lethargy 23.61 10.05 279 448354 51162 55792272
Body temperature decreased 23.42 10.05 234 448399 17874 55825560
General physical health deterioration 23.40 10.05 1614 447019 168396 55675038
Aggression 23.39 10.05 93 448540 21913 55821521
Substance abuse 23.27 10.05 4 448629 4521 55838913
Hepatotoxicity 23.21 10.05 149 448484 31004 55812430
Sinus tachycardia 23.14 10.05 96 448537 22348 55821086
Nervousness 23.06 10.05 136 448497 28879 55814555
Acute graft versus host disease 23.06 10.05 3 448630 4172 55839262
Cardiac failure acute 23.03 10.05 22 448611 8851 55834583
Hyperlipidaemia 22.96 10.05 71 448562 18038 55825396
Proteinuria 22.92 10.05 68 448565 17502 55825932
Developmental hip dysplasia 22.82 10.05 39 448594 1272 55842162
Acute generalised exanthematous pustulosis 22.79 10.05 27 448606 9842 55833592
Hypervolaemia 22.67 10.05 121 448512 26337 55817097
Aphasia 22.39 10.05 146 448487 30269 55813165
Dislocation of vertebra 22.34 10.05 94 448539 5321 55838113
Haemophagocytic lymphohistiocytosis 22.30 10.05 26 448607 9546 55833888
Pain in extremity 22.30 10.05 2702 445931 294729 55548705
Uterine perforation 22.29 10.05 12 448621 6493 55836941
Fear 22.24 10.05 54 448579 14854 55828580
Muscular weakness 22.18 10.05 648 447985 103804 55739630
Therapeutic response decreased 22.13 10.05 564 448069 52194 55791240
Oedema peripheral 22.11 10.05 1127 447506 170127 55673307
Breast cancer stage I 22.08 10.05 11 448622 6219 55837215
Retinitis 22.06 10.05 79 448554 4145 55839289
Red blood cell sedimentation rate 22.01 10.05 80 448553 4228 55839206
Dementia 21.95 10.05 67 448566 17091 55826343
Synovial fluid analysis 21.87 10.05 48 448585 1890 55841544
Dystonia 21.86 10.05 41 448592 12380 55831054
Angina pectoris 21.78 10.05 132 448501 27844 55815590
Mobility decreased 21.73 10.05 981 447652 98010 55745424
Fall 21.69 10.05 2506 446127 355004 55488430
Device related infection 21.69 10.05 95 448538 21785 55821649
Haemorrhage intracranial 21.66 10.05 43 448590 12712 55830722
Myopathy 21.44 10.05 28 448605 9784 55833650
Neck mass 21.43 10.05 68 448565 3352 55840082
Haemoptysis 21.37 10.05 124 448509 26436 55816998
Skin ulcer 21.29 10.05 429 448204 38179 55805255
Aspergillus infection 21.20 10.05 17 448616 7448 55835986
Loose body in joint 21.19 10.05 37 448596 1228 55842206
Placental disorder 21.17 10.05 40 448593 1413 55842021
Lymphocyte count decreased 21.14 10.05 133 448500 27806 55815628
Pemphigoid 21.04 10.05 12 448621 6288 55837146
Skin papilloma 20.97 10.05 81 448552 4408 55839026
Cerebral infarction 20.94 10.05 100 448533 22405 55821029
Product adhesion issue 20.90 10.05 5 448628 4478 55838956
Diabetes mellitus 20.89 10.05 295 448338 52440 55790994
Bronchopulmonary aspergillosis 20.86 10.05 21 448612 8243 55835191
Sleep apnoea syndrome 20.80 10.05 122 448511 25939 55817495
Premature delivery 20.78 10.05 317 448316 26743 55816691
Tardive dyskinesia 20.74 10.05 20 448613 8011 55835423
Bone marrow failure 20.71 10.05 136 448497 28150 55815284
Cardiogenic shock 20.71 10.05 64 448569 16261 55827173
Pulmonary congestion 20.56 10.05 63 448570 16052 55827382
Pancreatitis 20.50 10.05 245 448388 44835 55798599
Paradoxical drug reaction 20.49 10.05 3 448630 3817 55839617
Hot flush 20.47 10.05 256 448377 46470 55796964
Chills 20.44 10.05 642 447991 101962 55741472
Atrioventricular block 20.43 10.05 15 448618 6872 55836562
Rotator cuff repair 20.42 10.05 46 448587 1844 55841590
Peripheral venous disease 20.39 10.05 144 448489 9935 55833499
Cholecystitis chronic 20.12 10.05 29 448604 9719 55833715
Personality disorder 20.11 10.05 8 448625 5165 55838269
Blood glucose decreased 20.08 10.05 81 448552 19006 55824428
Colitis 19.88 10.05 225 448408 41586 55801848
Hallucination, visual 19.75 10.05 72 448561 17396 55826038
Affective disorder 19.69 10.05 10 448623 5593 55837841
Rash maculo-papular 19.68 10.05 142 448491 28765 55814669
Psychomotor hyperactivity 19.50 10.05 30 448603 9790 55833644
Exposure to toxic agent 19.48 10.05 3 448630 3675 55839759
Dysuria 19.47 10.05 154 448479 30575 55812859
Clostridium difficile colitis 19.41 10.05 80 448553 18658 55824776
Malignant melanoma 19.32 10.05 149 448484 10570 55832864
Exostosis 19.28 10.05 193 448440 14750 55828684
Lymphoedema 19.20 10.05 34 448599 10496 55832938
Leukocytosis 19.18 10.05 111 448522 23680 55819754
Complication of device removal 19.16 10.05 6 448627 4498 55838936
Polyhydramnios 19.09 10.05 48 448585 2067 55841367
Lip dry 19.03 10.05 138 448495 9602 55833832
Temperature regulation disorder 18.93 10.05 6 448627 4462 55838972
Bradyphrenia 18.90 10.05 15 448618 6605 55836829
Infusion site pain 18.88 10.05 52 448581 13710 55829724
Hereditary angioedema 18.87 10.05 16 448617 6819 55836615
Coronary artery disease 18.75 10.05 156 448477 30640 55812794
Immune reconstitution inflammatory syndrome 18.67 10.05 11 448622 5663 55837771
Mood altered 18.66 10.05 50 448583 13305 55830129
Tubulointerstitial nephritis 18.64 10.05 69 448564 16596 55826838
Hallucination, auditory 18.60 10.05 40 448593 11484 55831950
Urinary retention 18.58 10.05 139 448494 27935 55815499
Respiration abnormal 18.47 10.05 11 448622 5630 55837804
Cardiomyopathy 18.39 10.05 67 448566 16191 55827243
Body height below normal 18.35 10.05 46 448587 1977 55841457
Generalised oedema 18.28 10.05 57 448576 14444 55828990
Acute chest syndrome 18.27 10.05 25 448608 668 55842766
Pericardial effusion 18.25 10.05 134 448499 27041 55816393
Haematoma 18.25 10.05 165 448468 31854 55811580
Atrial septal defect 18.20 10.05 101 448532 6405 55837029
Skin exfoliation 18.16 10.05 197 448436 36703 55806731
Jaundice 18.13 10.05 135 448498 27159 55816275
Malaise 18.11 10.05 2613 446020 365247 55478187
Catheter site erythema 18.09 10.05 5 448628 4065 55839369
Incorrect route of product administration 18.02 10.05 98 448535 21231 55822203
Anuria 18.01 10.05 42 448591 11718 55831716
Facet joint syndrome 17.94 10.05 103 448530 6614 55836820
Pulmonary tuberculosis 17.92 10.05 77 448556 4399 55839035
Swollen tongue 17.84 10.05 155 448478 30169 55813265
Renal injury 17.79 10.05 27 448606 8860 55834574
Subdural haematoma 17.78 10.05 52 448581 13447 55829987
Off label use 17.73 10.05 4044 444589 552136 55291298
Synovial disorder 17.72 10.05 32 448601 1091 55842343
Salivary hypersecretion 17.70 10.05 18 448615 7032 55836402
Spinal stenosis 17.60 10.05 180 448453 13834 55829600
Hypothyroidism 17.59 10.05 207 448426 37989 55805445
Shock haemorrhagic 17.55 10.05 28 448605 9005 55834429
Right ventricular failure 17.55 10.05 69 448564 16310 55827124
Infusion site erythema 17.53 10.05 31 448602 9575 55833859
Oliguria 17.52 10.05 25 448608 8415 55835019
Lip swelling 17.43 10.05 130 448503 26142 55817292
Multiple allergies 17.30 10.05 36 448597 10460 55832974
Joint noise 17.25 10.05 68 448565 3736 55839698
Malignant mediastinal neoplasm 17.19 10.05 28 448605 877 55842557
Foetal anticonvulsant syndrome 17.19 10.05 22 448611 550 55842884
Hyperthyroidism 17.18 10.05 52 448581 13300 55830134
Acute myocardial infarction 17.15 10.05 157 448476 30236 55813198
Hypertransaminasaemia 17.15 10.05 8 448625 4699 55838735
Gastroenteritis viral 17.15 10.05 243 448390 20181 55823253
Pseudomonas infection 17.06 10.05 34 448599 10037 55833397
Urinary incontinence 17.06 10.05 152 448481 29433 55814001
Congenital arterial malformation 17.06 10.05 17 448616 320 55843114
Muscle twitching 17.04 10.05 69 448564 16173 55827261
Rebound effect 16.75 10.05 5 448628 3865 55839569
Purpura 16.70 10.05 36 448597 10326 55833108
Wound infection 16.69 10.05 190 448443 15003 55828431
Cyanosis 16.69 10.05 67 448566 15743 55827691
Cough 16.56 10.05 1816 446817 258145 55585289
Device breakage 16.56 10.05 35 448598 10112 55833322
Scleritis 16.56 10.05 66 448567 3645 55839789
Hypophagia 16.37 10.05 149 448484 28727 55814707
Ketoacidosis 16.35 10.05 6 448627 4069 55839365
Product preparation error 16.33 10.05 9 448624 4807 55838627
Rash erythematous 16.27 10.05 204 448429 37017 55806417
Bundle branch block left 16.25 10.05 16 448617 6346 55837088
Epilepsy 16.19 10.05 126 448507 25105 55818329
Fear of injection 16.18 10.05 98 448535 6417 55837017
Adjustment disorder with depressed mood 16.17 10.05 82 448551 5021 55838413
Catheter site pain 16.11 10.05 7 448626 4286 55839148
Klebsiella infection 16.08 10.05 23 448610 7733 55835701
Injection site warmth 16.05 10.05 179 448454 14064 55829370
Polyuria 16.04 10.05 22 448611 7529 55835905
Clear cell renal cell carcinoma 16.02 10.05 33 448600 1243 55842191
Postoperative wound infection 15.98 10.05 128 448505 9185 55834249
Product substitution issue 15.96 10.05 61 448572 14538 55828896
Eating disorder 15.92 10.05 76 448557 17029 55826405
Infusion site swelling 15.92 10.05 24 448609 7897 55835537
Dermatitis atopic 15.87 10.05 26 448607 8273 55835161
Fracture delayed union 15.87 10.05 48 448585 2305 55841129
Foetal death 15.83 10.05 120 448513 8467 55834967
Cushingoid 15.82 10.05 107 448526 7277 55836157
Myocarditis 15.80 10.05 29 448604 8829 55834605
Rhinitis allergic 15.78 10.05 27 448606 8447 55834987
Breast feeding 15.74 10.05 26 448607 824 55842610
Labelled drug-drug interaction medication error 15.73 10.05 44 448589 11542 55831892
Incorrect product administration duration 15.72 10.05 37 448596 10289 55833145
Haemorrhage in pregnancy 15.71 10.05 40 448593 1736 55841698
Multiple-drug resistance 15.69 10.05 6 448627 3968 55839466
Myoclonus 15.69 10.05 65 448568 15138 55828296
Anti-cyclic citrullinated peptide antibody 15.65 10.05 65 448568 3658 55839776
Epstein-Barr virus infection 15.60 10.05 22 448611 7441 55835993
Mental disorder 15.56 10.05 117 448516 23487 55819947
Vascular device infection 15.54 10.05 13 448620 5577 55837857
Visual acuity reduced 15.51 10.05 99 448534 20627 55822807
Epistaxis 15.45 10.05 411 448222 66612 55776822
Hemiplegia 15.45 10.05 27 448606 8377 55835057
Hallucinations, mixed 15.39 10.05 8 448625 4416 55839018
Presyncope 15.39 10.05 130 448503 25452 55817982
Fracture 15.38 10.05 215 448418 17803 55825631
Hyperprolactinaemia 15.36 10.05 5 448628 3656 55839778
Starvation ketoacidosis 15.26 10.05 9 448624 73 55843361
Head injury 15.25 10.05 127 448506 24939 55818495
Hypomagnesaemia 15.10 10.05 127 448506 24888 55818546
Tendonitis 15.07 10.05 215 448418 17882 55825552
Systemic inflammatory response syndrome 15.01 10.05 12 448621 5266 55838168
Blood loss anaemia 14.94 10.05 27 448606 8270 55835164
Injection site haematoma 14.87 10.05 93 448540 6159 55837275
Colitis microscopic 14.75 10.05 25 448608 7850 55835584
Sinus bradycardia 14.71 10.05 57 448576 13529 55829905
Human antichimeric antibody positive 14.66 10.05 36 448597 1527 55841907
Exomphalos 14.66 10.05 20 448613 533 55842901
Obesity 14.64 10.05 256 448377 22192 55821242
Cardiotoxicity 14.60 10.05 24 448609 7626 55835808
Renal disorder 14.59 10.05 158 448475 29447 55813987
Antinuclear antibody positive 14.58 10.05 99 448534 6742 55836692
Bundle branch block right 14.53 10.05 10 448623 4737 55838697
Transplant dysfunction 14.52 10.05 10 448623 4736 55838698
Dactylitis 14.41 10.05 43 448590 2049 55841385
Pulseless electrical activity 14.39 10.05 21 448612 7003 55836431
Talipes 14.37 10.05 34 448599 1408 55842026
Rectal haemorrhage 14.36 10.05 238 448395 41229 55802205
Hepatitis acute 14.34 10.05 28 448605 8329 55835105
Mouth ulceration 14.29 10.05 323 448310 29317 55814117
Graft versus host disease in gastrointestinal tract 14.26 10.05 3 448630 2936 55840498
Aspiration 14.23 10.05 35 448598 9586 55833848
Device issue 14.21 10.05 104 448529 21002 55822432
Delusion 14.20 10.05 44 448589 11171 55832263
Oropharyngeal pain 14.20 10.05 810 447823 82978 55760456
Amylase increased 14.19 10.05 15 448618 5756 55837678
Cholestasis of pregnancy 14.19 10.05 30 448603 1151 55842283
Visual impairment 14.12 10.05 467 448166 73735 55769699
Bradypnoea 14.11 10.05 4 448629 3199 55840235
Pneumonia viral 14.09 10.05 22 448611 7136 55836298
Respiratory acidosis 14.08 10.05 17 448616 6146 55837288
Poor venous access 14.02 10.05 155 448478 12151 55831283
Pregnancy with contraceptive device 14.02 10.05 8 448625 4191 55839243
Ileus 13.93 10.05 60 448573 13822 55829612
Stillbirth 13.89 10.05 91 448542 6123 55837311
Laryngospasm 13.88 10.05 3 448630 2881 55840553
Ear infection 13.85 10.05 337 448296 30958 55812476
Colorectal cancer 13.84 10.05 5 448628 3424 55840010
Cardiac disorder 13.80 10.05 270 448363 45617 55797817
Gestational hypertension 13.76 10.05 45 448588 2254 55841180
Trigeminal neuralgia 13.69 10.05 5 448628 3402 55840032
Cyst 13.68 10.05 159 448474 12619 55830815
Ankylosing spondylitis 13.66 10.05 130 448503 9800 55833634
Blood iron increased 13.63 10.05 33 448600 1387 55842047
Infusion site pruritus 13.59 10.05 11 448622 4796 55838638
Abnormal dreams 13.58 10.05 36 448597 9613 55833821
Sexual dysfunction 13.57 10.05 5 448628 3383 55840051
Foetal distress syndrome 13.50 10.05 31 448602 1259 55842175
Bursitis 13.43 10.05 301 448332 27281 55816153
Pharyngitis streptococcal 13.40 10.05 125 448508 9373 55834061
Acute respiratory distress syndrome 13.38 10.05 111 448522 21815 55821619
Affect lability 13.34 10.05 39 448594 10086 55833348
Acute coronary syndrome 13.33 10.05 37 448596 9731 55833703
Anger 13.27 10.05 48 448585 11624 55831810
Progressive multifocal leukoencephalopathy 13.26 10.05 50 448583 11963 55831471
Antibody test positive 13.15 10.05 46 448587 2385 55841049
HIV-associated neurocognitive disorder 13.11 10.05 10 448623 129 55843305
Peripheral sensory neuropathy 13.11 10.05 22 448611 6934 55836500
Immunodeficiency 13.08 10.05 191 448442 15966 55827468
Body temperature increased 13.05 10.05 193 448440 34049 55809385
Pulmonary alveolar haemorrhage 13.03 10.05 9 448624 4255 55839179
Paranoia 13.01 10.05 43 448590 10701 55832733
Tinnitus 13.00 10.05 165 448468 29877 55813557
Skin cancer 13.00 10.05 133 448500 10222 55833212
Product complaint 12.95 10.05 49 448584 11711 55831723
Cytomegalovirus viraemia 12.94 10.05 13 448620 5107 55838327
Neutropenic colitis 12.90 10.05 3 448630 2740 55840694
Immunosuppression 12.88 10.05 108 448525 7856 55835578
Paraesthesia 12.88 10.05 881 447752 129633 55713801
Acidosis 12.74 10.05 42 448591 10459 55832975
Sleep disorder due to a general medical condition 12.73 10.05 34 448599 9056 55834378
Blood urea increased 12.72 10.05 129 448504 24344 55819090
Chronic graft versus host disease 12.72 10.05 5 448628 3251 55840183
Embedded device 12.71 10.05 4 448629 2989 55840445
Prescribed underdose 12.70 10.05 233 448400 20384 55823050
Therapy change 12.69 10.05 15 448618 5473 55837961
Hyperuricaemia 12.68 10.05 13 448620 5060 55838374
Restless legs syndrome 12.65 10.05 81 448552 16866 55826568
Ileus paralytic 12.62 10.05 9 448624 4186 55839248
Speech disorder developmental 12.62 10.05 20 448613 612 55842822
Polydipsia 12.58 10.05 5 448628 3230 55840204
Middle insomnia 12.47 10.05 45 448588 10905 55832529
Drug screen positive 12.45 10.05 6 448627 3458 55839976
Lung transplant 12.41 10.05 4 448629 2943 55840491
Circulatory collapse 12.38 10.05 106 448527 20697 55822737
Food allergy 12.36 10.05 33 448600 8791 55834643
Embolism 12.36 10.05 25 448608 7339 55836095
Inflammatory marker increased 12.31 10.05 87 448546 6003 55837431
Neonatal respiratory distress syndrome 12.30 10.05 49 448584 2705 55840729
Pulmonary haemorrhage 12.28 10.05 22 448611 6761 55836673
Erythema 12.20 10.05 1073 447560 154866 55688568
Oral herpes 12.17 10.05 253 448380 22637 55820797
Tongue disorder 12.17 10.05 128 448505 9908 55833526
Intracranial pressure increased 12.11 10.05 11 448622 4534 55838900
Procedural pain 12.03 10.05 78 448555 16193 55827241
Crystal nephropathy 11.97 10.05 23 448610 823 55842611
Full blood count abnormal 11.96 10.05 144 448489 26318 55817116
Toxic epidermal necrolysis 11.95 10.05 115 448518 21927 55821507
Autism spectrum disorder 11.94 10.05 22 448611 762 55842672
Tumour marker increased 11.91 10.05 10 448623 4283 55839151
Lymphatic fistula 11.90 10.05 22 448611 764 55842670
Cervical incompetence 11.90 10.05 19 448614 585 55842849
Abortion incomplete 11.89 10.05 5 448628 3122 55840312
Human anti-human antibody test 11.88 10.05 16 448617 421 55843013
Potentiating drug interaction 11.88 10.05 9 448624 4057 55839377
Alcoholic liver disease 11.87 10.05 9 448624 115 55843319
Induced labour 11.81 10.05 24 448609 895 55842539
Rheumatoid lung 11.80 10.05 53 448580 3087 55840347
Ageusia 11.78 10.05 55 448578 12396 55831038
Product administered to patient of inappropriate age 11.75 10.05 4 448629 2844 55840590
Intervertebral disc degeneration 11.73 10.05 169 448464 14085 55829349
Treatment noncompliance 11.71 10.05 186 448447 32437 55810997
Dermatitis exfoliative 11.71 10.05 15 448618 5284 55838150
Abdominal pain upper 11.70 10.05 1243 447390 177070 55666364
Taste disorder 11.68 10.05 39 448594 9676 55833758
Joint lock 11.66 10.05 41 448592 2131 55841303
Catheter management 11.61 10.05 4 448629 2822 55840612
Lymphopenia 11.61 10.05 82 448551 16692 55826742
Femoral hernia incarcerated 11.60 10.05 22 448611 779 55842655
Atrial flutter 11.59 10.05 36 448597 9133 55834301
Foot fracture 11.58 10.05 241 448392 21568 55821866
Serum ferritin increased 11.54 10.05 80 448553 5485 55837949
Lipase increased 11.53 10.05 35 448598 8944 55834490
Hypertelorism 11.51 10.05 16 448617 434 55843000
Deep vein thrombosis postoperative 11.48 10.05 63 448570 3978 55839456
Multiple drug therapy 11.39 10.05 4 448629 2788 55840646
Occult blood 11.38 10.05 28 448605 1189 55842245
Eosinophil count increased 11.38 10.05 39 448594 9598 55833836
Bone lesion 11.36 10.05 16 448617 5414 55838020
Pathogen resistance 11.28 10.05 19 448614 5981 55837453
Plasma cell myeloma recurrent 11.27 10.05 4 448629 2770 55840664
Blood parathyroid hormone decreased 11.26 10.05 109 448524 8255 55835179
Forceps delivery 11.25 10.05 11 448622 202 55843232
Product physical issue 11.16 10.05 12 448621 4570 55838864
Sickle cell anaemia 11.16 10.05 18 448615 559 55842875
Ulcer 11.15 10.05 246 448387 22239 55821195
Madarosis 11.13 10.05 4 448629 2749 55840685
Onychomycosis 11.10 10.05 90 448543 6482 55836952
Granuloma skin 11.08 10.05 95 448538 6956 55836478
Prescribed overdose 11.07 10.05 244 448389 22052 55821382
Herpes zoster 11.06 10.05 724 447909 75165 55768269
Breast cancer stage II 11.05 10.05 18 448615 5740 55837694
Flatulence 11.02 10.05 179 448454 31109 55812325
Wound infection pseudomonas 11.00 10.05 29 448604 1286 55842148
Metastases to lymph nodes 10.98 10.05 27 448606 7396 55836038
Pancreatic steatosis 10.95 10.05 24 448609 944 55842490
Joint warmth 10.93 10.05 31 448602 1435 55841999
Body mass index decreased 10.90 10.05 15 448618 403 55843031
Hyperthermia 10.85 10.05 32 448601 8253 55835181
Hepatitis fulminant 10.85 10.05 6 448627 3198 55840236
Muscle rigidity 10.78 10.05 46 448587 10625 55832809
Renal tubular necrosis 10.74 10.05 47 448586 10781 55832653
Joint injury 10.68 10.05 274 448359 25380 55818054
Nail injury 10.68 10.05 17 448616 522 55842912
Adenovirus infection 10.67 10.05 7 448626 3401 55840033
Haemodialysis 10.67 10.05 34 448599 8557 55834877
Anterior chamber cleavage syndrome 10.66 10.05 10 448623 174 55843260
Coordination abnormal 10.66 10.05 58 448575 12563 55830871
Oxygen consumption increased 10.65 10.05 8 448625 3623 55839811
Endodontic procedure 10.62 10.05 49 448584 2887 55840547
Device deployment issue 10.61 10.05 8 448625 3616 55839818
Hepatitis cholestatic 10.57 10.05 22 448611 6392 55837042
Respiratory syncytial virus infection 10.54 10.05 17 448616 5444 55837990
Bacteraemia 10.53 10.05 77 448556 15554 55827880
Ear pain 10.47 10.05 178 448455 30712 55812722
Maternal exposure during breast feeding 10.46 10.05 57 448576 3590 55839844
Mental impairment 10.45 10.05 59 448574 12663 55830771
Foetal alcohol syndrome 10.44 10.05 5 448628 25 55843409
Mycobacterium tuberculosis complex test positive 10.40 10.05 37 448596 1935 55841499
Abortion threatened 10.36 10.05 17 448616 536 55842898
Hypoglycaemic coma 10.35 10.05 3 448630 2364 55841070
Paraesthesia oral 10.31 10.05 70 448563 14379 55829055
Tendon disorder 10.31 10.05 77 448556 5408 55838026
Kidney transplant rejection 10.30 10.05 11 448622 4202 55839232
Breast cancer female 10.25 10.05 57 448576 12281 55831153
Electrolyte imbalance 10.24 10.05 93 448540 17940 55825494
Retrognathia 10.23 10.05 15 448618 428 55843006
Drug abuser 10.20 10.05 5 448628 2854 55840580
Product prescribing error 10.16 10.05 127 448506 23059 55820375
Hypoventilation 10.16 10.05 12 448621 4380 55839054
Learning disorder 10.11 10.05 18 448615 607 55842827
Dermatitis bullous 10.10 10.05 29 448604 7544 55835890
Catatonia 10.09 10.05 10 448623 3954 55839480
Bone disorder 10.07 10.05 215 448418 19328 55824106

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 446.62 10.13 839 159768 46970 31489767
Drug abuse 311.26 10.13 39 160568 87719 31449018
Foetal exposure during pregnancy 303.43 10.13 652 159955 40224 31496513
Completed suicide 236.64 10.13 84 160523 91430 31445307
Arthralgia 225.22 10.13 1424 159183 150000 31386737
Toxicity to various agents 211.85 10.13 372 160235 181115 31355622
Psoriatic arthropathy 147.27 10.13 317 160290 19566 31517171
Dysmorphism 128.59 10.13 114 160493 2958 31533779
Joint swelling 113.67 10.13 554 160053 52877 31483860
Sickle cell anaemia with crisis 110.14 10.13 102 160505 2805 31533932
Drug interaction 101.95 10.13 629 159978 207914 31328823
Premature baby 89.79 10.13 247 160360 17819 31518918
Musculoskeletal stiffness 85.39 10.13 425 160182 40900 31495837
Enthesopathy 82.19 10.13 105 160502 4182 31532555
Death 81.73 10.13 1311 159296 359258 31177479
Exposure during pregnancy 75.38 10.13 147 160460 8451 31528286
Blood pressure fluctuation 73.55 10.13 268 160339 22468 31514269
Tenosynovitis 72.78 10.13 98 160509 4112 31532625
Intentional overdose 72.23 10.13 62 160545 41327 31495410
Speech disorder developmental 70.89 10.13 69 160538 2022 31534715
Neonatal respiratory distress syndrome 64.98 10.13 89 160518 3796 31532941
Synovitis 64.11 10.13 171 160436 12112 31524625
Pain 64.08 10.13 1314 159293 185445 31351292
Foetal anticonvulsant syndrome 60.46 10.13 49 160558 1120 31535617
Atrial septal defect 60.20 10.13 118 160489 6809 31529928
Hypospadias 59.23 10.13 76 160531 3040 31533697
Product use in unapproved indication 58.32 10.13 281 160326 98890 31437847
Drug resistance 56.47 10.13 24 160583 23429 31513308
Hepatic function abnormal 56.09 10.13 76 160531 41146 31495591
Acute kidney injury 55.83 10.13 1040 159567 278674 31258063
Maternal exposure during pregnancy 55.45 10.13 91 160516 4565 31532172
C-reactive protein abnormal 54.26 10.13 121 160486 7648 31529089
Autism spectrum disorder 52.26 10.13 60 160547 2135 31534602
Lower respiratory tract infection 51.81 10.13 281 160326 27956 31508781
Maternal drugs affecting foetus 51.59 10.13 80 160527 3823 31532914
Nasopharyngitis 51.34 10.13 518 160089 62727 31474010
Blood pressure systolic increased 50.41 10.13 214 160393 19256 31517481
Hypoglycaemia neonatal 49.84 10.13 53 160554 1729 31535008
Small for dates baby 49.84 10.13 76 160531 3579 31533158
Arthropathy 49.41 10.13 247 160360 23804 31512933
Febrile neutropenia 49.33 10.13 388 160219 121461 31415276
Cryptorchism 48.46 10.13 55 160552 1932 31534805
Learning disorder 47.85 10.13 41 160566 1015 31535722
Suicide attempt 47.39 10.13 72 160535 37176 31499561
Arthritis 47.22 10.13 268 160339 27117 31509620
Alanine aminotransferase abnormal 46.53 10.13 77 160530 3890 31532847
Low birth weight baby 45.84 10.13 106 160501 6864 31529873
Drug dependence 45.63 10.13 29 160578 22550 31514187
Maternal exposure during breast feeding 44.97 10.13 47 160560 1502 31535235
Psoriasis 44.56 10.13 396 160211 46323 31490414
Tongue disorder 44.25 10.13 86 160521 4931 31531806
Ventricular septal defect 43.97 10.13 72 160535 3605 31533132
Sopor 43.81 10.13 4 160603 11548 31525189
Rheumatoid nodule 42.72 10.13 60 160547 2621 31534116
Syndactyly 42.10 10.13 35 160572 830 31535907
Overdose 40.92 10.13 256 160351 84408 31452329
Cardiac failure 40.46 10.13 262 160345 85691 31451046
Foot deformity 40.16 10.13 74 160533 4075 31532662
Disease progression 39.97 10.13 281 160326 90183 31446554
Rhabdomyolysis 39.22 10.13 177 160430 63404 31473333
Blood pressure diastolic abnormal 37.30 10.13 70 160537 3909 31532828
Developmental delay 36.70 10.13 55 160552 2550 31534187
Drug intolerance 36.54 10.13 414 160193 51619 31485118
Blood pressure systolic abnormal 36.31 10.13 60 160547 3027 31533710
Coma 35.80 10.13 99 160508 41051 31495686
C-reactive protein increased 35.49 10.13 390 160217 48260 31488477
Haemoglobin decreased 35.08 10.13 782 159825 111893 31424844
Pulmonary fibrosis 34.86 10.13 172 160435 16488 31520249
Basal cell carcinoma 34.77 10.13 183 160424 17996 31518741
Intentional product misuse 34.76 10.13 89 160518 37862 31498875
Infusion related reaction 34.49 10.13 384 160223 47671 31489066
Joint laxity 34.33 10.13 23 160584 388 31536349
Cytomegalovirus infection 34.17 10.13 45 160562 24662 31512075
Tendonitis 33.93 10.13 108 160499 8450 31528287
Osteoarthritis 33.80 10.13 188 160419 18879 31517858
Talipes 33.49 10.13 44 160563 1802 31534935
Exposure via breast milk 33.23 10.13 44 160563 1816 31534921
Respiratory arrest 32.21 10.13 52 160555 26205 31510532
Drug reaction with eosinophilia and systemic symptoms 31.86 10.13 65 160542 29953 31506784
Renal failure 31.71 10.13 437 160170 122893 31413844
Hand deformity 31.60 10.13 56 160551 2991 31533746
Congenital hand malformation 31.09 10.13 25 160582 565 31536172
Heart rate decreased 30.87 10.13 247 160360 28019 31508718
Pain in extremity 30.85 10.13 789 159818 115414 31421323
Multiple organ dysfunction syndrome 30.54 10.13 211 160396 67992 31468745
Peripheral swelling 30.37 10.13 498 160109 67367 31469370
Joint effusion 30.30 10.13 70 160537 4529 31532208
Jaundice neonatal 30.05 10.13 35 160572 1265 31535472
Intellectual disability 29.94 10.13 34 160573 1195 31535542
Blood pressure diastolic decreased 29.85 10.13 99 160508 7914 31528823
Palmar-plantar erythrodysaesthesia syndrome 29.78 10.13 21 160586 15462 31521275
Hypermobility syndrome 29.72 10.13 20 160587 340 31536397
Drug withdrawal syndrome 29.30 10.13 31 160576 18719 31518018
Plagiocephaly 29.01 10.13 23 160584 509 31536228
Body temperature decreased 27.90 10.13 126 160481 11644 31525093
Poisoning 27.76 10.13 9 160598 10382 31526355
Language disorder 27.34 10.13 43 160564 2080 31534657
Foetal growth restriction 27.30 10.13 60 160547 3755 31532982
Blood pressure increased 27.13 10.13 560 160047 79073 31457664
Astigmatism 26.96 10.13 30 160577 1031 31535706
Poisoning deliberate 26.66 10.13 3 160604 7341 31529396
Serum ferritin increased 26.63 10.13 77 160530 5715 31531022
Dysgraphia 26.45 10.13 43 160564 2140 31534597
Polyarthritis 26.15 10.13 63 160544 4189 31532548
Pathogen resistance 26.13 10.13 6 160601 8695 31528042
Pancytopenia 25.91 10.13 602 160005 86714 31450023
Large for dates baby 25.83 10.13 27 160580 863 31535874
Somnolence 25.69 10.13 352 160255 99093 31437644
Off label use 25.52 10.13 1470 159137 345804 31190933
Knee arthroplasty 25.31 10.13 82 160525 6476 31530261
Selective eating disorder 25.22 10.13 37 160570 1683 31535054
Vitamin B1 deficiency 24.76 10.13 17 160590 299 31536438
Mobility decreased 24.74 10.13 230 160377 27239 31509498
Knee deformity 24.52 10.13 22 160585 580 31536157
Urticaria 24.26 10.13 181 160426 57336 31479401
Hyperbilirubinaemia neonatal 24.25 10.13 24 160583 718 31536019
Suicidal ideation 23.88 10.13 99 160508 36307 31500430
Rash maculo-papular 23.79 10.13 60 160547 25659 31511078
Inflammation 23.57 10.13 213 160394 25028 31511709
Substance abuse 23.45 10.13 4 160603 7154 31529583
Hypotonia neonatal 23.44 10.13 31 160576 1278 31535459
Hypoglycaemia 23.10 10.13 157 160450 50789 31485948
Grip strength decreased 22.90 10.13 45 160562 2601 31534136
Motor developmental delay 22.79 10.13 22 160585 638 31536099
Pyrexia 22.69 10.13 1284 159323 302556 31234181
Vitamin B12 deficiency 22.57 10.13 53 160554 3466 31533271
Bradycardia 22.26 10.13 234 160373 69093 31467644
Neck mass 22.00 10.13 33 160574 1531 31535206
Caesarean section 21.93 10.13 37 160570 1899 31534838
Acute hepatic failure 21.54 10.13 20 160587 12839 31523898
Renal impairment 21.46 10.13 308 160299 86041 31450696
Encephalitis toxic 21.41 10.13 15 160592 273 31536464
Altered state of consciousness 21.16 10.13 47 160560 21004 31515733
Constipation 21.07 10.13 473 160134 123518 31413219
Red blood cell sedimentation rate increased 21.03 10.13 91 160516 8255 31528482
Otitis media 20.86 10.13 43 160564 2573 31534164
Shock 20.82 10.13 53 160554 22592 31514145
Nasal disorder 20.78 10.13 34 160573 1701 31535036
Joint stiffness 20.64 10.13 103 160504 9918 31526819
Plasma cell myeloma 20.59 10.13 185 160422 56346 31480391
Dyspraxia 20.49 10.13 17 160590 402 31536335
Anal fistula 20.48 10.13 62 160545 4721 31532016
No adverse event 20.40 10.13 43 160564 19582 31517155
Diaphragmatic disorder 20.40 10.13 27 160580 1114 31535623
Vitamin D deficiency 20.09 10.13 71 160536 5861 31530876
Strabismus 19.96 10.13 32 160575 1574 31535163
Hyperglycaemia 19.91 10.13 106 160501 36370 31500367
Blood pressure diastolic increased 19.83 10.13 57 160550 4216 31532521
Cleft lip 19.75 10.13 15 160592 311 31536426
Drug withdrawal syndrome neonatal 19.64 10.13 50 160557 3442 31533295
Poor venous access 19.50 10.13 55 160552 4025 31532712
Musculoskeletal pain 19.45 10.13 234 160373 29594 31507143
Dyslexia 19.42 10.13 15 160592 319 31536418
Appendicolith 19.23 10.13 3 160604 5728 31531009
Behaviour disorder 19.23 10.13 57 160550 4290 31532447
Neck pain 19.23 10.13 189 160418 22721 31514016
Malignant neoplasm progression 19.20 10.13 283 160324 78715 31458022
Decreased gait velocity 19.16 10.13 11 160596 139 31536598
Foetal disorder 19.04 10.13 22 160585 788 31535949
Depressed level of consciousness 19.01 10.13 116 160491 38485 31498252
Skin cancer 19.00 10.13 96 160511 9289 31527448
Venoocclusive liver disease 18.80 10.13 7 160600 7405 31529332
Blood parathyroid hormone decreased 18.75 10.13 28 160579 1294 31535443
Hydrocele 18.73 10.13 35 160572 1948 31534789
Weight decreased 18.66 10.13 990 159617 158962 31377775
Aptyalism 18.56 10.13 14 160593 287 31536450
Agitation neonatal 18.40 10.13 25 160582 1058 31535679
Umbilical hernia 18.40 10.13 55 160552 4159 31532578
Psychotic disorder 18.39 10.13 55 160552 22238 31514499
Medical device implantation 18.34 10.13 19 160588 601 31536136
Arthritis bacterial 18.26 10.13 58 160549 4532 31532205
Angioedema 18.18 10.13 98 160509 33520 31503217
Aspergillus infection 18.08 10.13 19 160588 11509 31525228
Radiation inflammation 17.88 10.13 18 160589 550 31536187
Red blood cell sedimentation rate 17.73 10.13 24 160583 1012 31535725
Lacrimal disorder 17.69 10.13 14 160593 309 31536428
Congenital bladder anomaly 17.51 10.13 13 160594 260 31536477
Limb reduction defect 17.47 10.13 13 160594 261 31536476
Weight decrease neonatal 17.24 10.13 14 160593 321 31536416
Congenital anomaly 17.14 10.13 27 160580 1308 31535429
Haematocrit decreased 17.12 10.13 230 160377 29831 31506906
Joint range of motion decreased 17.07 10.13 73 160534 6588 31530149
Post procedural infection 16.95 10.13 56 160551 4467 31532270
Respiratory rate increased 16.95 10.13 92 160515 9153 31527584
Loss of personal independence in daily activities 16.76 10.13 218 160389 28070 31508667
Congenital foot malformation 16.76 10.13 15 160592 394 31536343
Ear infection 16.70 10.13 89 160518 8792 31527945
Infective pulmonary exacerbation of cystic fibrosis 16.65 10.13 6 160601 6478 31530259
Multiple congenital abnormalities 16.63 10.13 17 160590 529 31536208
Ankyloglossia congenital 16.54 10.13 13 160594 284 31536453
Mastication disorder 16.41 10.13 25 160582 1176 31535561
Renal aplasia 16.39 10.13 19 160588 683 31536054
Wound 16.38 10.13 117 160490 12811 31523926
Attention deficit hyperactivity disorder 16.35 10.13 37 160570 2361 31534376
Ear disorder 16.23 10.13 27 160580 1370 31535367
Cardiac arrest 16.21 10.13 336 160271 88726 31448011
Patent ductus arteriosus 16.20 10.13 44 160563 3149 31533588
Respiratory disorder neonatal 16.18 10.13 28 160579 1467 31535270
Asthma 16.16 10.13 138 160469 42473 31494264
Granuloma skin 16.11 10.13 24 160583 1107 31535630
Haemangioma congenital 16.05 10.13 16 160591 483 31536254
Finger deformity 16.04 10.13 25 160582 1200 31535537
Therapeutic product effect decreased 16.02 10.13 237 160370 31385 31505352
Microcephaly 15.98 10.13 20 160587 780 31535957
Sarcopenia 15.89 10.13 14 160593 360 31536377
Bronchiolitis 15.73 10.13 41 160566 2863 31533874
Malignant melanoma 15.72 10.13 79 160528 7628 31529109
Psychomotor retardation 15.70 10.13 44 160563 3208 31533529
Second primary malignancy 15.68 10.13 8 160599 7024 31529713
Neurotoxicity 15.68 10.13 37 160570 16189 31520548
Osteonecrosis of jaw 15.65 10.13 40 160567 17031 31519706
Juvenile idiopathic arthritis 15.64 10.13 30 160577 1703 31535034
Cerebral haemorrhage neonatal 15.55 10.13 12 160595 255 31536482
Failure to anastomose 15.53 10.13 11 160596 204 31536533
Scoliosis 15.44 10.13 38 160569 2561 31534176
Product quality issue 15.36 10.13 37 160570 16074 31520663
Tuberculosis 15.29 10.13 83 160524 8258 31528479
Arthrodesis 15.26 10.13 15 160592 445 31536292
Spinal disorder 15.11 10.13 49 160558 3871 31532866
Arnold-Chiari malformation 15.06 10.13 13 160594 325 31536412
Haemangioma 15.05 10.13 30 160577 1752 31534985
Back disorder 15.02 10.13 66 160541 6027 31530710
Wrong technique in product usage process 14.99 10.13 103 160504 33240 31503497
Pectus excavatum 14.99 10.13 11 160596 216 31536521
Bradycardia neonatal 14.75 10.13 21 160586 929 31535808
Lactic acidosis 14.69 10.13 98 160509 31839 31504898
Oxygen saturation decreased 14.67 10.13 339 160268 48776 31487961
C-reactive protein decreased 14.67 10.13 30 160577 1785 31534952
Blood folate decreased 14.66 10.13 18 160589 688 31536049
Lung neoplasm malignant 14.66 10.13 136 160471 16094 31520643
Drug ineffective for unapproved indication 14.59 10.13 44 160563 17746 31518991
Foetal distress syndrome 14.58 10.13 22 160585 1026 31535711
Oesophageal fibrosis 14.56 10.13 10 160597 176 31536561
Hypertelorism 14.47 10.13 16 160591 546 31536191
Hypertriglyceridaemia 14.45 10.13 11 160596 7787 31528950
Tooth malformation 14.32 10.13 10 160597 181 31536556
Cholelithiasis 14.12 10.13 156 160451 19323 31517414
Proteinuria 14.08 10.13 41 160566 16722 31520015
Neutropenia 14.02 10.13 575 160032 139789 31396948
Foetal heart rate deceleration abnormality 14.01 10.13 15 160592 493 31536244
Septic arthritis staphylococcal 13.99 10.13 15 160592 494 31536243
Infection 13.91 10.13 527 160080 81404 31455333
Maternal exposure timing unspecified 13.90 10.13 13 160594 362 31536375
Emphysema 13.90 10.13 85 160522 8833 31527904
Kidney infection 13.89 10.13 55 160552 4795 31531942
Polydactyly 13.77 10.13 23 160584 1171 31535566
Obsessive-compulsive disorder 13.68 10.13 4 160603 4933 31531804
Progressive multifocal leukoencephalopathy 13.55 10.13 16 160591 9197 31527540
Incorrect route of product administration 13.50 10.13 24 160583 11649 31525088
Sedation 13.44 10.13 50 160557 18915 31517822
Hepatitis E antibody positive 13.41 10.13 11 160596 256 31536481
Cystitis haemorrhagic 13.41 10.13 5 160602 5284 31531453
Disseminated intravascular coagulation 13.37 10.13 56 160551 20481 31516256
Haemolysis 13.36 10.13 72 160535 7144 31529593
Chronic graft versus host disease 13.24 10.13 3 160604 4389 31532348
Hernia pain 13.19 10.13 11 160596 262 31536475
Inguinal hernia 13.19 10.13 70 160537 6905 31529832
Immunodeficiency 13.16 10.13 53 160554 4656 31532081
Joint injury 13.03 10.13 76 160531 7765 31528972
Sexual dysfunction 13.00 10.13 7 160600 5961 31530776
Oropharyngeal pain 12.97 10.13 228 160379 31255 31505482
Injection site pain 12.93 10.13 247 160360 34387 31502350
Vomiting 12.84 10.13 969 159638 223004 31313733
Alcoholic liver disease 12.77 10.13 15 160592 547 31536190
Aggression 12.73 10.13 124 160483 37167 31499570
Hepatic enzyme increased 12.70 10.13 254 160353 35654 31501083
Vascular insufficiency 12.69 10.13 12 160595 339 31536398
Communication disorder 12.67 10.13 34 160573 2416 31534321
Gastrointestinal infection 12.61 10.13 53 160554 4747 31531990
Spina bifida 12.60 10.13 12 160595 342 31536395
Blood insulin increased 12.46 10.13 12 160595 347 31536390
Anal atresia 12.45 10.13 11 160596 284 31536453
Hepatitis E virus test positive 12.45 10.13 11 160596 284 31536453
Fall 12.34 10.13 1099 159508 184990 31351747
Acute graft versus host disease 12.30 10.13 8 160599 6145 31530592
Arthritis infective 12.29 10.13 38 160569 2927 31533810
Developmental coordination disorder 12.25 10.13 9 160598 177 31536560
Irritability 12.22 10.13 67 160540 22822 31513915
Liver function test abnormal 12.22 10.13 215 160392 29477 31507260
Pharyngeal disorder 12.07 10.13 16 160591 661 31536076
Synovial cyst 12.07 10.13 30 160577 2035 31534702
End stage renal disease 12.02 10.13 14 160593 8095 31528642
Crohn's disease 12.02 10.13 47 160560 4074 31532663
Erythrosis 12.01 10.13 6 160601 56 31536681
Ear malformation 12.01 10.13 11 160596 298 31536439
Suspected suicide 12 10.13 3 160604 4104 31532633
Localised infection 11.88 10.13 124 160483 15141 31521596
Blood test abnormal 11.86 10.13 62 160545 6079 31530658
Cellulitis 11.84 10.13 323 160284 47695 31489042
Palindromic rheumatism 11.83 10.13 9 160598 187 31536550
Low set ears 11.79 10.13 13 160594 442 31536295
Peripheral artery thrombosis 11.75 10.13 31 160576 2181 31534556
Cardiogenic shock 11.74 10.13 66 160541 22342 31514395
Maternal exposure before pregnancy 11.63 10.13 16 160591 685 31536052
Gangrene neonatal 11.63 10.13 9 160598 192 31536545
Intentional self-injury 11.60 10.13 32 160575 13283 31523454
Respiratory failure 11.58 10.13 409 160198 101040 31435697
Pleural fibrosis 11.58 10.13 23 160584 1340 31535397
Contraindicated product administered 11.56 10.13 152 160455 19620 31517117
Abnormal behaviour 11.52 10.13 72 160535 23756 31512981
Respiratory tract infection viral 11.50 10.13 29 160578 1985 31534752
Educational problem 11.49 10.13 14 160593 531 31536206
Panniculitis 11.47 10.13 27 160580 1769 31534968
Nodule 11.38 10.13 58 160549 5632 31531105
Back pain 11.34 10.13 670 159937 108743 31427994
Congenital hydronephrosis 11.32 10.13 16 160591 703 31536034
Cerebral haemorrhage 11.25 10.13 109 160498 32703 31504034
Adenovirus infection 11.23 10.13 5 160602 4749 31531988
Bloody discharge 11.20 10.13 12 160595 395 31536342
Neonatal seizure 11.14 10.13 13 160594 471 31536266
Withdrawal syndrome 11.10 10.13 27 160580 11690 31525047
Depression 11.09 10.13 363 160244 90452 31446285
Pulmonary artery stenosis congenital 11.09 10.13 13 160594 473 31536264
Folate deficiency 11.09 10.13 21 160586 1181 31535556
Posterior reversible encephalopathy syndrome 11.07 10.13 19 160588 9348 31527389
BK virus infection 11.06 10.13 6 160601 5089 31531648
Erectile dysfunction 11 10.13 55 160552 19180 31517557
Neonatal infection 10.96 10.13 12 160595 405 31536332
Meningeal disorder 10.96 10.13 11 160596 335 31536402
Stevens-Johnson syndrome 10.92 10.13 48 160559 17324 31519413
Blood lactic acid increased 10.91 10.13 9 160598 6121 31530616
Blood magnesium decreased 10.89 10.13 58 160549 5728 31531009
Injection site haemorrhage 10.81 10.13 81 160526 9004 31527733
Diverticular perforation 10.79 10.13 38 160569 3131 31533606
Excessive cerumen production 10.77 10.13 10 160597 276 31536461
Acute chest syndrome 10.72 10.13 11 160596 344 31536393
Upper respiratory tract infection 10.70 10.13 209 160398 29213 31507524
Tooth injury 10.69 10.13 20 160587 1114 31535623
Pulmonary arterial hypertension 10.65 10.13 21 160586 9800 31526937
Chronic obstructive pulmonary disease 10.63 10.13 302 160305 44864 31491873
Gross motor delay 10.62 10.13 10 160597 281 31536456
Acute generalised exanthematous pustulosis 10.59 10.13 9 160598 6031 31530706
Injection site bruising 10.59 10.13 73 160534 7902 31528835
Regurgitation 10.55 10.13 22 160585 1327 31535410
Neutropenia neonatal 10.49 10.13 15 160592 666 31536071
Nail bed inflammation 10.48 10.13 8 160599 167 31536570
Coma scale abnormal 10.48 10.13 42 160565 3681 31533056
Lower respiratory tract congestion 10.48 10.13 19 160588 1033 31535704
Drug level below therapeutic 10.48 10.13 52 160555 4996 31531741
Anti-erythropoietin antibody positive 10.44 10.13 17 160590 847 31535890
Decreased appetite 10.41 10.13 653 159954 152564 31384173
Mouth ulceration 10.36 10.13 92 160515 10756 31525981
Fine motor skill dysfunction 10.35 10.13 25 160582 1665 31535072
Brain oedema 10.34 10.13 32 160575 12800 31523937
Blood creatine phosphokinase increased 10.32 10.13 150 160457 41824 31494913
Transplant rejection 10.32 10.13 21 160586 9687 31527050
Pancreatitis chronic 10.31 10.13 29 160578 2119 31534618
Bronchopulmonary aspergillosis 10.29 10.13 35 160572 13599 31523138
PCO2 decreased 10.27 10.13 25 160582 1673 31535064
Akathisia 10.24 10.13 13 160594 7240 31529497
Cirrhosis alcoholic 10.22 10.13 16 160591 771 31535966
Myopia 10.21 10.13 19 160588 1054 31535683
Skin ulcer 10.21 10.13 150 160457 19835 31516902
Heart rate irregular 10.16 10.13 114 160493 14175 31522562
Thinking abnormal 10.15 10.13 8 160599 5565 31531172

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1666.24 9.99 4909 456057 286896 70180582
Completed suicide 966.98 9.99 158 460808 226977 70240501
Pemphigus 927.86 9.99 1815 459151 81221 70386257
Arthropathy 920.78 9.99 2593 458373 147464 70320014
Joint swelling 914.04 9.99 3658 457308 249553 70217925
Hand deformity 886.99 9.99 1824 459142 84658 70382820
Systemic lupus erythematosus 886.91 9.99 2011 458955 99891 70367587
Synovitis 861.30 9.99 2302 458664 126926 70340552
Glossodynia 797.72 9.99 1747 459219 84740 70382738
Toxicity to various agents 760.25 9.99 818 460148 381354 70086124
Arthralgia 727.59 9.99 5673 455293 497717 69969761
Anti-cyclic citrullinated peptide antibody positive 683.02 9.99 1449 459517 68736 70398742
Maternal exposure during pregnancy 664.45 9.99 1949 459017 113396 70354082
Drug abuse 662.22 9.99 87 460879 147169 70320309
Wound 659.89 9.99 1761 459205 96971 70370507
Infusion related reaction 651.84 9.99 2777 458189 194757 70272721
Pericarditis 649.19 9.99 1591 459375 83114 70384364
Abdominal discomfort 536.07 9.99 2783 458183 211875 70255603
Alopecia 510.62 9.99 2595 458371 195895 70271583
Pain 508.76 9.99 6277 454689 622539 69844939
Swelling 501.96 9.99 2489 458477 186050 70281428
Discomfort 500.39 9.99 1666 459300 103770 70363708
Therapeutic product effect decreased 498.38 9.99 2045 458921 140973 70326505
Contraindicated product administered 464.43 9.99 1919 459047 132693 70334785
Duodenal ulcer perforation 422.67 9.99 989 459977 50123 70417355
Helicobacter infection 418.48 9.99 1038 459928 54618 70412860
Death 418.25 9.99 1800 459166 508261 69959217
Drug intolerance 408.02 9.99 2687 458279 223000 70244478
Rheumatoid factor positive 396.38 9.99 933 460033 47467 70420011
Drug interaction 395.03 9.99 1221 459745 380220 70087258
Nasopharyngitis 394.70 9.99 2634 458332 219572 70247906
Musculoskeletal stiffness 391.92 9.99 1949 459017 145811 70321667
Hepatic enzyme increased 379.01 9.99 2017 458949 154973 70312505
Exposure during pregnancy 327.57 9.99 1282 459684 86435 70381043
Intentional overdose 324.26 9.99 117 460849 98318 70369160
Febrile neutropenia 277.30 9.99 569 460397 203749 70263729
Impaired healing 273.63 9.99 1082 459884 73292 70394186
Psoriatic arthropathy 263.53 9.99 973 459993 63798 70403680
Lower respiratory tract infection 255.87 9.99 1417 459549 110496 70356982
Treatment failure 246.93 9.99 1694 459272 142448 70325030
Hypersensitivity 246.78 9.99 2429 458537 227383 70240095
C-reactive protein abnormal 246.39 9.99 677 460289 37902 70429576
Acute kidney injury 245.45 9.99 1942 459024 472682 69994796
Muscle injury 241.38 9.99 671 460295 37823 70429655
Sinusitis 235.05 9.99 1892 459074 167303 70300175
Peripheral swelling 231.85 9.99 2454 458512 234109 70233369
Folliculitis 227.58 9.99 701 460265 41869 70425609
Irritable bowel syndrome 222.25 9.99 782 460184 50068 70417410
Product use issue 220.77 9.99 1957 459009 177980 70289498
Red blood cell sedimentation rate abnormal 208.23 9.99 416 460550 18887 70448591
Sleep disorder due to general medical condition, insomnia type 207.64 9.99 606 460360 35126 70432352
Blister 205.08 9.99 1235 459731 99291 70368187
Overdose 193.96 9.99 518 460448 169227 70298251
Depressed level of consciousness 187.28 9.99 175 460791 87256 70380222
Arthritis 184.98 9.99 1180 459786 96800 70370678
Suicide attempt 183.84 9.99 148 460818 79362 70388116
Blood pressure fluctuation 180.81 9.99 812 460154 58200 70409278
Cardiac arrest 178.67 9.99 493 460473 159341 70308137
Knee arthroplasty 177.03 9.99 558 460408 33743 70433735
Hip arthroplasty 175.03 9.99 488 460478 27552 70439926
Sickle cell anaemia with crisis 174.85 9.99 205 460761 5773 70461705
Osteoarthritis 170.20 9.99 940 460026 73207 70394271
Weight increased 169.30 9.99 2358 458608 239973 70227505
Cardiac failure 157.27 9.99 447 460519 143094 70324384
Pregnancy 151.52 9.99 417 460549 23364 70444114
Disease progression 150.41 9.99 518 460448 156154 70311324
Respiratory arrest 148.02 9.99 83 460883 53850 70413628
Malignant neoplasm progression 147.91 9.99 360 460606 121379 70346099
Renal failure 144.99 9.99 683 460283 188387 70279091
Infection 144.75 9.99 2045 458921 208740 70258738
Rhabdomyolysis 143.58 9.99 251 460715 95509 70371969
Neutropenia 139.80 9.99 1037 459929 256119 70211359
Hepatic function abnormal 137.66 9.99 143 460823 67853 70399625
Constipation 134.83 9.99 1023 459943 251415 70216063
Bradycardia 134.35 9.99 391 460575 124224 70343254
Sopor 132.33 9.99 22 460944 31245 70436233
Rheumatic fever 132.29 9.99 329 460637 17331 70450147
Ill-defined disorder 129.66 9.99 700 460266 54041 70413437
Drug ineffective 128.51 9.99 7393 453573 932359 69535119
Lactic acidosis 123.65 9.99 144 460822 64880 70402598
Drug reaction with eosinophilia and systemic symptoms 122.03 9.99 118 460848 57895 70409583
Red blood cell sedimentation rate increased 121.59 9.99 536 460430 38106 70429372
Sedation 121.10 9.99 77 460889 46654 70420824
Blood pressure systolic increased 120.93 9.99 710 460256 56549 70410929
Abortion spontaneous 120.71 9.99 413 460553 26066 70441412
Drug resistance 119.74 9.99 49 460917 38141 70429337
Contusion 116.86 9.99 1310 459656 126726 70340752
Condition aggravated 115.71 9.99 3616 457350 424019 70043459
Multiple organ dysfunction syndrome 112.28 9.99 347 460619 108168 70359310
Drug dependence 110.51 9.99 52 460914 37269 70430209
Blood pressure diastolic abnormal 110.05 9.99 283 460683 15221 70452257
Swollen joint count increased 108.77 9.99 261 460705 13439 70454039
Hypoglycaemia 106.95 9.99 289 460677 94075 70373403
Cytomegalovirus infection 105.11 9.99 64 460902 39694 70427784
Fibromyalgia 103.94 9.99 598 460368 47276 70420202
Joint effusion 101.20 9.99 274 460692 15203 70452275
Hypotension 100.60 9.99 1937 459029 402444 70065034
Somnolence 100.42 9.99 906 460060 214700 70252778
Osteoporosis 99.79 9.99 601 460365 48306 70419172
Enthesopathy 99.46 9.99 219 460747 10650 70456828
Blood pressure systolic abnormal 99.35 9.99 243 460723 12666 70454812
Injection site erythema 98.73 9.99 811 460155 72113 70395365
Respiratory failure 97.19 9.99 669 460297 168066 70299412
Poisoning deliberate 97.06 9.99 3 460963 17057 70450421
Rash 97.04 9.99 4149 456817 506413 69961065
C-reactive protein increased 96.45 9.99 1121 459845 109396 70358082
Renal impairment 96.18 9.99 545 460421 143392 70324086
Grip strength decreased 95.94 9.99 271 460695 15414 70452064
Foot deformity 95.76 9.99 324 460642 20331 70447147
Product use in unapproved indication 92.67 9.99 881 460085 206597 70260881
Gastrointestinal disorder 90.94 9.99 1067 459899 104360 70363118
Fatigue 90.80 9.99 6367 454599 817952 69649526
Cardio-respiratory arrest 90.53 9.99 342 460624 100335 70367143
Hyperglycaemia 88.58 9.99 179 460787 64493 70402985
Rheumatoid nodule 87.97 9.99 256 460710 14811 70452667
Intentional product misuse 87.78 9.99 247 460719 79348 70388130
Blood pressure diastolic decreased 87.57 9.99 366 460600 25414 70442064
Neoplasm progression 87.24 9.99 99 460867 45129 70422349
Device expulsion 87.04 9.99 19 460947 22227 70445251
Plasma cell myeloma 86.14 9.99 220 460746 72981 70394497
Inflammation 85.02 9.99 833 460133 77832 70389646
Pain in extremity 84.66 9.99 2759 458207 325323 70142155
Live birth 84.21 9.99 238 460728 13541 70453937
Intentional self-injury 82.21 9.99 52 460914 31598 70435880
Poisoning 81.37 9.99 23 460943 22599 70444879
Disability assessment scale score increased 80.51 9.99 98 460868 2873 70464605
Tenosynovitis 80.20 9.99 236 460730 13740 70453738
Cardiac failure congestive 80.02 9.99 533 460433 134924 70332554
Stomatitis 79.96 9.99 1226 459740 127285 70340193
Injection site pruritus 79.45 9.99 481 460485 38729 70428749
Agitation 78.99 9.99 325 460641 93050 70374428
Bone erosion 77.52 9.99 246 460720 14927 70452551
Injection site reaction 77.20 9.99 572 460394 49280 70418198
Syncope 76.84 9.99 697 460269 165012 70302466
Serotonin syndrome 76.11 9.99 97 460869 42017 70425461
Disseminated intravascular coagulation 75.84 9.99 64 460902 33534 70433944
Coma 75.63 9.99 323 460643 91521 70375957
Musculoskeletal pain 75.18 9.99 908 460058 89419 70378059
Pulmonary arterial hypertension 74.88 9.99 62 460904 32793 70434685
Heart rate decreased 74.15 9.99 671 460295 61344 70406134
Joint stiffness 73.50 9.99 435 460531 34741 70432737
Hepatic failure 71.88 9.99 168 460798 57457 70410021
Thrombocytopenia 69.72 9.99 1113 459853 237997 70229481
Drug withdrawal syndrome 69.43 9.99 66 460900 32649 70434829
Asthma 69.01 9.99 480 460486 120313 70347165
Hypoxia 68.71 9.99 342 460624 93002 70374476
Altered state of consciousness 68.45 9.99 96 460870 39926 70427552
Tachycardia 68.33 9.99 679 460287 157867 70309611
Shock 68.11 9.99 98 460868 40327 70427151
Sedation complication 67.87 9.99 5 460961 13405 70454073
Palmar-plantar erythrodysaesthesia syndrome 67.80 9.99 58 460908 30189 70437289
Caesarean section 65.65 9.99 195 460771 11412 70456066
Joint laxity 64.76 9.99 78 460888 2261 70465217
Injection site pain 64.16 9.99 1098 459868 116521 70350957
Blood cholesterol increased 63.99 9.99 672 460294 63932 70403546
Cholestasis 63.44 9.99 135 460831 47737 70419741
Loss of personal independence in daily activities 63.18 9.99 836 460130 84074 70383404
Psoriasis 63.13 9.99 944 460022 97489 70369989
Vomiting 62.16 9.99 3186 457780 589925 69877553
Neuropathy peripheral 61.80 9.99 527 460439 126369 70341109
Hyperhidrosis 60.76 9.99 554 460412 131032 70336446
Injection site swelling 60.59 9.99 484 460482 42673 70424805
Polyarthritis 60.17 9.99 180 460786 10576 70456902
Joint range of motion decreased 59.73 9.99 330 460636 25696 70441782
Localised infection 58.67 9.99 393 460573 32765 70434713
Body temperature decreased 58.26 9.99 352 460614 28320 70439158
Basal cell carcinoma 58.19 9.99 397 460569 33301 70434177
Juvenile idiopathic arthritis 57.82 9.99 121 460845 5679 70461799
Immune reconstitution inflammatory syndrome 57.58 9.99 8 460958 12982 70454496
Electrocardiogram QT prolonged 57.53 9.99 313 460653 83204 70384274
Gestational diabetes 57.29 9.99 123 460843 5878 70461600
Joint destruction 56.79 9.99 106 460860 4572 70462906
Myalgia 56.76 9.99 759 460207 167133 70300345
Mobility decreased 56.71 9.99 963 460003 102036 70365442
Cerebral haemorrhage 56.59 9.99 171 460795 53693 70413785
Myocardial infarction 56.22 9.99 781 460185 170864 70296614
Post transplant lymphoproliferative disorder 56.15 9.99 3 460963 10542 70456936
Tendonitis 55.88 9.99 288 460678 21834 70445644
Hyponatraemia 55.48 9.99 720 460246 159367 70308111
Blood pressure increased 55.38 9.99 1611 459355 186906 70280572
Mydriasis 55.25 9.99 18 460948 16135 70451343
Respiratory depression 55.19 9.99 48 460918 24783 70442695
Tremor 54.64 9.99 698 460268 154926 70312552
Orthostatic hypotension 54.55 9.99 164 460802 51579 70415899
Pulmonary fibrosis 54.45 9.99 396 460570 33914 70433564
Anxiety 54.19 9.99 1057 459909 219273 70248205
Tongue disorder 54.02 9.99 199 460767 13028 70454450
Acute hepatic failure 53.99 9.99 60 460906 27612 70439866
Blood pressure diastolic increased 53.64 9.99 190 460776 12201 70455277
Intentional product use issue 53.54 9.99 1087 459879 119055 70348423
Leukopenia 53.03 9.99 440 460526 106120 70361358
Femur fracture 52.80 9.99 409 460557 35723 70431755
Nausea 52.51 9.99 4797 456169 847291 69620187
Hepatocellular injury 52.33 9.99 141 460825 45950 70421528
Anaemia 52.13 9.99 2118 458848 401305 70066173
Disability 51.11 9.99 213 460753 14770 70452708
Metabolic acidosis 51.00 9.99 279 460687 74067 70393411
Red blood cell sedimentation rate 50.79 9.99 104 460862 4806 70462672
Neutrophil count decreased 50.74 9.99 326 460640 83230 70384248
Nodule 50.46 9.99 260 460706 19709 70447769
Dehydration 50.26 9.99 1103 459863 225039 70242439
Dyspnoea 50.09 9.99 4317 456649 765743 69701735
Angioedema 49.62 9.99 243 460723 66367 70401111
Injection site bruising 49.35 9.99 419 460547 37613 70429865
Asthenia 49.31 9.99 2451 458515 455215 70012263
Cognitive disorder 49.18 9.99 216 460750 60740 70406738
Hyperkalaemia 49.10 9.99 449 460517 106142 70361336
Venoocclusive liver disease 48.71 9.99 6 460960 10672 70456806
Aspergillus infection 48.30 9.99 28 460938 17840 70449638
Alanine aminotransferase abnormal 48.08 9.99 138 460828 7921 70459557
Abnormal behaviour 47.58 9.99 96 460870 34613 70432865
Laryngitis 47.46 9.99 195 460771 13436 70454042
Ventricular tachycardia 47.20 9.99 104 460862 36319 70431159
Blood creatine phosphokinase increased 47.09 9.99 221 460745 61042 70406436
Seizure 46.77 9.99 844 460122 177118 70290360
Tenderness 46.72 9.99 266 460700 20944 70446534
Infective pulmonary exacerbation of cystic fibrosis 46.33 9.99 11 460955 12147 70455331
Suspected suicide 45.56 9.99 3 460963 8831 70458647
Anaphylactic shock 45.28 9.99 89 460877 32401 70435077
Diarrhoea 45.23 9.99 4431 456535 778910 69688568
Synovial cyst 44.90 9.99 142 460824 8600 70458878
Neurotoxicity 44.85 9.99 78 460888 29748 70437730
Pulmonary embolism 44.57 9.99 728 460238 155139 70312339
Drug ineffective for unapproved indication 44.43 9.99 117 460849 38421 70429057
Skin ulcer 44.07 9.99 493 460473 47652 70419826
Injection site rash 43.81 9.99 217 460749 16193 70451285
Disturbance in attention 43.76 9.99 138 460828 42756 70424722
Substance abuse 43.74 9.99 6 460960 9831 70457647
Maternal exposure before pregnancy 43.28 9.99 84 460882 3732 70463746
Neck deformity 42.79 9.99 55 460911 1706 70465772
Oropharyngeal pain 42.78 9.99 871 460095 95439 70372039
Multiple sclerosis relapse 42.77 9.99 140 460826 42877 70424601
Blood glucose increased 42.72 9.99 445 460521 102537 70364941
Multiple fractures 42.47 9.99 118 460848 6647 70460831
Brain oedema 42.25 9.99 54 460912 23364 70444114
Asphyxia 42.19 9.99 8 460958 10334 70457144
Second primary malignancy 42.14 9.99 16 460950 13035 70454443
Fracture 41.90 9.99 247 460719 19697 70447781
Vision blurred 41.66 9.99 405 460561 94579 70372899
Product quality issue 41.49 9.99 85 460881 30476 70437002
Poor venous access 41.42 9.99 200 460766 14771 70452707
Ejection fraction decreased 41.39 9.99 86 460880 30676 70436802
Neck mass 41.35 9.99 87 460879 4099 70463379
Unresponsive to stimuli 41.30 9.99 185 460781 51746 70415732
Atrial fibrillation 41.28 9.99 898 460068 183450 70284028
Restlessness 41.27 9.99 138 460828 41990 70425488
Hallucination 41.14 9.99 308 460658 75952 70391526
Joint injury 41.11 9.99 308 460658 26624 70440854
Lupus-like syndrome 41.10 9.99 166 460800 11349 70456129
Adverse event 41.05 9.99 497 460469 48964 70418514
Creatinine renal clearance decreased 41.03 9.99 31 460935 17169 70450309
Mental status changes 41.01 9.99 241 460725 62860 70404618
Cerebral infarction 40.70 9.99 143 460823 42866 70424612
No adverse event 40.69 9.99 93 460873 32060 70435418
Ear infection 40.44 9.99 319 460647 28017 70439461
Torsade de pointes 40.29 9.99 35 460931 18081 70449397
Posterior reversible encephalopathy syndrome 40.28 9.99 60 460906 24342 70443136
Pathogen resistance 40.09 9.99 18 460948 13261 70454217
Diabetic ketoacidosis 40.00 9.99 91 460875 31421 70436057
Ventricular fibrillation 39.77 9.99 72 460894 27039 70440439
Speech disorder 39.74 9.99 181 460785 50399 70417079
Irritability 39.69 9.99 122 460844 38103 70429375
Depression 39.60 9.99 987 459979 197987 70269491
Latent tuberculosis 39.50 9.99 72 460894 3049 70464429
Disorientation 39.38 9.99 218 460748 57705 70409773
Transplant rejection 39.34 9.99 36 460930 18135 70449343
Cardiogenic shock 39.05 9.99 114 460852 36193 70431285
Coronary artery disease 38.99 9.99 243 460723 62493 70404985
Limb deformity 38.97 9.99 76 460890 3389 70464089
Psychotic disorder 38.67 9.99 121 460845 37580 70429898
Drug use disorder 38.64 9.99 4 460962 8147 70459331
Pre-eclampsia 38.64 9.99 111 460855 6374 70461104
Pulmonary oedema 38.58 9.99 345 460621 81933 70385545
Bronchopulmonary aspergillosis 38.34 9.99 48 460918 20954 70446524
Arrhythmia 38.34 9.99 211 460755 55932 70411546
Encephalopathy 38.24 9.99 239 460727 61422 70406056
Urticaria 38.03 9.99 789 460177 162260 70305218
Rash maculo-papular 37.87 9.99 184 460782 50361 70417117
Melaena 37.83 9.99 213 460753 56142 70411336
Exostosis 37.80 9.99 189 460777 14156 70453322
Decreased appetite 37.66 9.99 1608 459358 303172 70164306
Dizziness 37.48 9.99 2555 458411 461586 70005892
Premature delivery 37.39 9.99 252 460714 21052 70446426
Premature rupture of membranes 37.33 9.99 80 460886 3818 70463660
Aggression 37.09 9.99 175 460791 48271 70419207
Type 2 diabetes mellitus 37.05 9.99 444 460522 43636 70423842
Osteonecrosis of jaw 37.03 9.99 139 460827 40863 70426615
Thrombotic microangiopathy 36.72 9.99 37 460929 17811 70449667
Premature labour 36.65 9.99 125 460841 7875 70459603
Fluid retention 36.62 9.99 251 460715 63134 70404344
Therapeutic response decreased 36.46 9.99 558 460408 57895 70409583
Proteinuria 36.34 9.99 86 460880 29288 70438190
Sepsis 36.18 9.99 1263 459703 243282 70224196
Balance disorder 35.95 9.99 393 460573 89735 70377743
Respiratory distress 35.90 9.99 208 460758 54442 70413036
Joint dislocation 35.89 9.99 188 460778 14343 70453135
Accidental overdose 35.82 9.99 113 460853 35008 70432470
Hypokalaemia 35.79 9.99 618 460348 130570 70336908
Withdrawal syndrome 35.77 9.99 67 460899 24837 70442641
Acute graft versus host disease 35.76 9.99 9 460957 9553 70457925
Colorectal cancer 35.75 9.99 6 460960 8464 70459014
Suicidal ideation 35.70 9.99 285 460681 69311 70398167
Agranulocytosis 35.50 9.99 138 460828 40160 70427318
Drug level increased 35.35 9.99 120 460846 36349 70431129
Maternal exposure timing unspecified 35.23 9.99 84 460882 4307 70463171
Smear cervix abnormal 35.17 9.99 59 460907 2337 70465141
Unintentional medical device removal 35.09 9.99 3 460963 7121 70460357
Akathisia 35.07 9.99 18 460948 12275 70455203
Arthritis infective 35.00 9.99 117 460849 7295 70460183
Fear of injection 34.84 9.99 109 460857 6563 70460915
Haematotoxicity 34.78 9.99 23 460943 13651 70453827
Cytokine release syndrome 34.77 9.99 75 460891 26392 70441086
Neuroleptic malignant syndrome 34.74 9.99 73 460893 25934 70441544
Graft versus host disease 34.67 9.99 28 460938 14995 70452483
Blood parathyroid hormone decreased 34.56 9.99 133 460833 8891 70458587
Wrong technique in product usage process 34.47 9.99 283 460683 68415 70399063
Herpes zoster 34.34 9.99 760 460206 84475 70383003
Blood creatinine increased 34.24 9.99 689 460277 142312 70325166
Ascites 34.01 9.99 278 460688 67269 70400209
Wheelchair user 33.78 9.99 92 460874 5122 70462356
Cerebrovascular accident 33.24 9.99 695 460271 142775 70324703
Product administration error 33.00 9.99 91 460875 29432 70438046
Tachypnoea 32.97 9.99 87 460879 28551 70438927
Delirium 32.78 9.99 318 460648 74296 70393182
Coagulopathy 32.51 9.99 109 460857 33140 70434338
White blood cell count decreased 32.50 9.99 849 460117 169292 70298186
Pleural effusion 32.46 9.99 638 460328 132226 70335252
Loss of consciousness 32.46 9.99 767 460199 154949 70312529
Extrapyramidal disorder 32.37 9.99 53 460913 20697 70446781
Chronic kidney disease 32.27 9.99 248 460718 60809 70406669
Ischaemic stroke 32.26 9.99 98 460868 30722 70436756
Oral herpes 32.19 9.99 268 460698 23918 70443560
Acute myeloid leukaemia 31.94 9.99 99 460867 30841 70436637
Granuloma skin 31.73 9.99 116 460850 7566 70459912
Gastrointestinal haemorrhage 31.73 9.99 666 460300 136742 70330736
Hyperthermia 31.60 9.99 37 460929 16634 70450844
Haemoptysis 31.10 9.99 201 460765 51251 70416227
Tenosynovitis stenosans 31.03 9.99 55 460911 2278 70465200
Platelet count decreased 31.03 9.99 901 460065 177321 70290157
BK virus infection 30.90 9.99 7 460959 7982 70459496
Hypothermia 30.83 9.99 54 460912 20540 70446938
Psychomotor hyperactivity 30.62 9.99 33 460933 15400 70452078
Tuberculosis 30.62 9.99 183 460783 14665 70452813
Bursitis 30.56 9.99 286 460680 26387 70441091
Immunodeficiency 30.42 9.99 207 460759 17348 70450130
Deep vein thrombosis 30.31 9.99 523 460443 110519 70356959
Mouth ulceration 30.20 9.99 349 460617 34000 70433478
Chest discomfort 30.16 9.99 598 460368 123783 70343695
Erythema multiforme 30.09 9.99 38 460928 16526 70450952
Eosinophilia 30.08 9.99 147 460819 40172 70427306
Emotional distress 29.86 9.99 132 460834 37056 70430422
Myoclonus 29.63 9.99 81 460885 26274 70441204
Foot fracture 29.27 9.99 223 460743 19377 70448101
Forced expiratory volume decreased 29.12 9.99 6 460960 7308 70460170
Panniculitis 29.09 9.99 142 460824 10534 70456944
Joint noise 29.01 9.99 67 460899 3364 70464114
Bone disorder 28.98 9.99 204 460762 17286 70450192
Rotator cuff repair 28.82 9.99 44 460922 1607 70465871
Status epilepticus 28.62 9.99 74 460892 24452 70443026
Dysgeusia 28.60 9.99 196 460770 49306 70418172
Pulmonary hypertension 28.53 9.99 181 460785 46355 70421123
Clostridium difficile colitis 28.39 9.99 95 460871 28901 70438577
Pyrexia 28.36 9.99 3483 457483 603469 69864009
Peripheral venous disease 28.30 9.99 141 460825 10546 70456932
Acute respiratory distress syndrome 28.19 9.99 155 460811 41099 70426379
Bronchospasm 27.98 9.99 67 460899 22725 70444753
Graft versus host disease in gastrointestinal tract 27.97 9.99 3 460963 5941 70461537
Haemophagocytic lymphohistiocytosis 27.96 9.99 53 460913 19559 70447919
Spinal stenosis 27.95 9.99 177 460789 14476 70453002
Ulcer 27.95 9.99 273 460693 25481 70441997
Stevens-Johnson syndrome 27.91 9.99 129 460837 35778 70431700
Aspartate aminotransferase increased 27.71 9.99 621 460345 126357 70341121
Aphasia 27.67 9.99 166 460800 43083 70424395
Retinitis 27.55 9.99 74 460892 4086 70463392
Synovial fluid analysis 27.40 9.99 46 460920 1823 70465655
Paradoxical drug reaction 27.36 9.99 5 460961 6631 70460847
Hypertransaminasaemia 27.19 9.99 12 460954 8931 70458547
Blood alkaline phosphatase increased 27.17 9.99 246 460720 58275 70409203
Gastroenteritis viral 27.11 9.99 235 460731 21220 70446258
Miosis 27.05 9.99 31 460935 14070 70453408
Skin papilloma 27.02 9.99 87 460879 5319 70462159
Mania 26.66 9.99 44 460922 17130 70450348
Pancreatitis acute 26.66 9.99 178 460788 45046 70422432
Lip dry 26.55 9.99 130 460836 9655 70457823
Loose body in joint 26.52 9.99 37 460929 1244 70466234
Acute chest syndrome 26.50 9.99 32 460934 930 70466548
Anaphylactic reaction 26.40 9.99 336 460630 74638 70392840
Appendicolith 26.39 9.99 3 460963 5677 70461801
Angina pectoris 26.29 9.99 195 460771 48188 70419290
Vitamin B1 deficiency 25.95 9.99 26 460940 610 70466868
Flushing 25.79 9.99 377 460589 81795 70385683
Fear 25.69 9.99 61 460905 20750 70446728
Febrile bone marrow aplasia 25.67 9.99 24 460942 11967 70455511
Bone pain 25.66 9.99 209 460757 50613 70416865
Blood pressure decreased 25.64 9.99 429 460537 91086 70376392
Pulmonary alveolar haemorrhage 25.63 9.99 18 460948 10351 70457127
Acute respiratory failure 25.61 9.99 224 460742 53441 70414037
Scleritis 25.59 9.99 66 460900 3556 70463922
Gamma-glutamyltransferase increased 25.34 9.99 209 460757 50476 70417002
Pancytopenia 25.31 9.99 1213 459753 149894 70317584
Acute generalised exanthematous pustulosis 25.28 9.99 38 460928 15359 70452119
Blood calcium decreased 25.27 9.99 99 460867 28747 70438731
Endophthalmitis 25.18 9.99 5 460961 6250 70461228
Injection site warmth 25.15 9.99 165 460801 13660 70453818
Dysarthria 25.13 9.99 271 460695 62042 70405436
Pain in jaw 25.13 9.99 168 460798 42501 70424977
Face oedema 25.10 9.99 84 460882 25555 70441923
Inappropriate antidiuretic hormone secretion 25.09 9.99 73 460893 23203 70444275
Metastases to bone 24.99 9.99 69 460897 22307 70445171
Facet joint syndrome 24.99 9.99 92 460874 6021 70461457
Blood bilirubin increased 24.77 9.99 259 460707 59642 70407836
Foetal death 24.75 9.99 93 460873 6146 70461332
Klebsiella infection 24.72 9.99 34 460932 14258 70453220
Respiration abnormal 24.65 9.99 7 460959 6857 70460621
Vertigo 24.64 9.99 274 460692 62369 70405109
Respiratory disorder 24.59 9.99 151 460815 38972 70428506
Stress cardiomyopathy 24.54 9.99 17 460949 9845 70457633
Cytopenia 24.53 9.99 47 460919 17276 70450202
Cyst 24.49 9.99 154 460812 12565 70454913
Hepatitis B reactivation 24.45 9.99 3 460963 5352 70462126
Cytomegalovirus viraemia 24.30 9.99 24 460942 11661 70455817
Adenovirus infection 24.30 9.99 10 460956 7758 70459720
Skin cancer 24.29 9.99 161 460805 13375 70454103
Cardiac failure acute 24.28 9.99 48 460918 17439 70450039
Fracture delayed union 24.18 9.99 46 460920 2013 70465465
Chronic graft versus host disease 24.13 9.99 7 460959 6763 70460715
Device difficult to use 24.08 9.99 21 460945 10828 70456650
Anuria 23.94 9.99 58 460908 19595 70447883
Chest pain 23.92 9.99 1362 459604 249898 70217580
Cystitis haemorrhagic 23.90 9.99 13 460953 8580 70458898
Pemphigoid 23.61 9.99 34 460932 13988 70453490
Malignant melanoma 23.55 9.99 163 460803 13737 70453741
Subdural haematoma 23.52 9.99 104 460862 29194 70438284
Hyperuricaemia 23.41 9.99 22 460944 10944 70456534
Shock haemorrhagic 23.21 9.99 52 460914 18054 70449424
Interstitial lung disease 23.11 9.99 511 460455 104174 70363304
Nocardiosis 23.11 9.99 3 460963 5126 70462352
Bronchitis 23.11 9.99 957 460009 116286 70351192
Glycosylated haemoglobin increased 23.08 9.99 49 460917 17342 70450136
Haemorrhage intracranial 23.03 9.99 83 460883 24694 70442784
Surgery 23.02 9.99 297 460669 29692 70437786
Myelosuppression 23.01 9.99 109 460857 30036 70437442
Oliguria 22.96 9.99 39 460927 15012 70452466
Leukocytosis 22.95 9.99 157 460809 39511 70427967
Influenza 22.85 9.99 930 460036 112770 70354708
Exposure to toxic agent 22.84 9.99 6 460960 6188 70461290
Dislocation of vertebra 22.83 9.99 77 460889 4823 70462655
Affective disorder 22.80 9.99 10 460956 7469 70460009
Disease recurrence 22.67 9.99 147 460819 37456 70430022
Cardiac failure chronic 22.64 9.99 20 460946 10249 70457229
Acute graft versus host disease in skin 22.63 9.99 9 460957 7128 70460350
Metastases to liver 22.55 9.99 89 460877 25789 70441689
Anhedonia 22.45 9.99 36 460930 14177 70453301
Pancreatitis 22.38 9.99 280 460686 62388 70405090
Bradyphrenia 22.38 9.99 19 460947 9927 70457551
Breast cancer stage I 22.33 9.99 6 460960 6096 70461382
Tumour lysis syndrome 22.30 9.99 68 460898 21292 70446186
Epstein-Barr virus infection 22.23 9.99 32 460934 13166 70454312
Polyhydramnios 21.99 9.99 37 460929 1469 70466009
Acute myocardial infarction 21.97 9.99 337 460629 72550 70394928
Device use error 21.97 9.99 8 460958 6688 70460790
Dyspnoea exertional 21.86 9.99 368 460598 78062 70389416
Haemorrhage 21.84 9.99 398 460568 83417 70384061
Potentiating drug interaction 21.78 9.99 13 460953 8151 70459327
Muscle spasticity 21.77 9.99 61 460905 19628 70447850
Progressive multifocal leukoencephalopathy 21.64 9.99 59 460907 19155 70448323
Rebound effect 21.61 9.99 6 460960 5965 70461513
Post procedural infection 21.61 9.99 128 460838 10225 70457253
Palpitations 21.58 9.99 551 460415 110202 70357276
Dermatitis acneiform 21.49 9.99 16 460950 8929 70458549
Drug tolerance decreased 21.45 9.99 123 460843 9710 70457768
Incorrect route of product administration 21.29 9.99 94 460872 26398 70441080
Anti-cyclic citrullinated peptide antibody 21.21 9.99 59 460907 3326 70464152
Adjustment disorder with depressed mood 21.14 9.99 68 460898 4155 70463323
Blood lactic acid increased 20.96 9.99 25 460941 11148 70456330
Hyperthyroidism 20.94 9.99 64 460902 20027 70447451
Renal injury 20.81 9.99 46 460920 16048 70451430
Malignant mediastinal neoplasm 20.75 9.99 27 460939 848 70466630
Hallucination, visual 20.72 9.99 109 460857 29228 70438250
Ileus 20.71 9.99 84 460882 24153 70443325
Oxygen saturation decreased 20.64 9.99 940 460026 115489 70351989
Electrocardiogram QRS complex prolonged 20.55 9.99 20 460946 9786 70457692
Toxic skin eruption 20.47 9.99 65 460901 20097 70447381
Muscle spasms 20.43 9.99 806 460160 153240 70314238
Postoperative wound infection 20.43 9.99 135 460831 11203 70456275
Pulmonary congestion 20.37 9.99 89 460877 25065 70442413
Dyskinesia 20.24 9.99 170 460796 40904 70426574
Rhinorrhoea 20.24 9.99 570 460396 65801 70401677
Lipase increased 20.19 9.99 43 460923 15203 70452275
Antinuclear antibody positive 20.15 9.99 93 460873 6740 70460738
Synovial disorder 20.11 9.99 30 460936 1073 70466405
Cyanosis 20.10 9.99 80 460886 23126 70444352
Sciatica 19.80 9.99 246 460720 24381 70443097
Enterocolitis 19.80 9.99 34 460932 13032 70454446
Polyneuropathy 19.73 9.99 72 460894 21343 70446135
International normalised ratio increased 19.60 9.99 388 460578 80338 70387140
Off label use 19.58 9.99 4403 456563 738657 69728821
Musculoskeletal disorder 19.42 9.99 207 460759 19764 70447714
Hyperammonaemia 19.34 9.99 23 460943 10270 70457208
Dactylitis 19.32 9.99 44 460922 2189 70465289
Tubulointerstitial nephritis 19.09 9.99 131 460835 32945 70434533
Hepatic cirrhosis 19.02 9.99 293 460673 30438 70437040
Breast feeding 18.90 9.99 23 460943 674 70466804
Foetal distress syndrome 18.85 9.99 19 460947 449 70467029
Stillbirth 18.81 9.99 61 460905 3744 70463734
End stage renal disease 18.74 9.99 27 460939 11106 70456372
Sexual dysfunction 18.74 9.99 10 460956 6671 70460807
Endodontic procedure 18.72 9.99 47 460919 2490 70464988
Paralysis 18.67 9.99 31 460935 12041 70455437
Hemiplegia 18.56 9.99 39 460927 13856 70453622
Rheumatoid lung 18.52 9.99 57 460909 3402 70464076
Ingrown hair 18.47 9.99 22 460944 630 70466848
Human antichimeric antibody positive 18.39 9.99 34 460932 1456 70466022
Metastases to lung 18.28 9.99 51 460915 16433 70451045
Sinus bradycardia 18.28 9.99 85 460881 23538 70443940
Sinus tachycardia 18.27 9.99 137 460829 33776 70433702
Hepatitis fulminant 18.24 9.99 10 460956 6571 70460907
Hyperbilirubinaemia 18.18 9.99 80 460886 22488 70444990
Wound infection 18.09 9.99 184 460782 17358 70450120
Decreased gait velocity 18.05 9.99 12 460954 153 70467325
Labelled drug-drug interaction medication error 17.97 9.99 88 460878 24039 70443439
Gastric haemorrhage 17.97 9.99 41 460925 14144 70453334
Pharyngitis streptococcal 17.94 9.99 114 460852 9334 70458144
Right ventricular failure 17.92 9.99 79 460887 22195 70445283
Nephropathy toxic 17.89 9.99 61 460905 18453 70449025
Lymphocyte count decreased 17.70 9.99 189 460777 43350 70424128
Venoocclusive disease 17.67 9.99 3 460963 4197 70463281
Coordination abnormal 17.60 9.99 50 460916 16016 70451462
Nightmare 17.57 9.99 79 460887 22077 70445401
Haemoglobin decreased 17.54 9.99 1555 459411 203604 70263874
Haematuria 17.48 9.99 299 460667 63274 70404204
Hepatotoxicity 17.45 9.99 192 460774 43794 70423684
Pleuritic pain 17.30 9.99 108 460858 8789 70458689
Feeling abnormal 17.11 9.99 753 460213 141566 70325912
Metastases to central nervous system 17.06 9.99 46 460920 14988 70452490
Cushingoid 17.05 9.99 103 460863 8285 70459193
Peripheral sensory neuropathy 17.02 9.99 33 460933 12077 70455401
Temperature regulation disorder 16.98 9.99 4 460962 4440 70463038
Bacteraemia 16.96 9.99 116 460850 29193 70438285
Pulseless electrical activity 16.90 9.99 38 460928 13177 70454301
Acute coronary syndrome 16.90 9.99 70 460896 20009 70447469
Onychomycosis 16.85 9.99 89 460877 6812 70460666
Alcoholic liver disease 16.80 9.99 19 460947 514 70466964
Hyperprolactinaemia 16.80 9.99 4 460962 4409 70463069
Induced labour 16.78 9.99 24 460942 826 70466652
Haematocrit decreased 16.70 9.99 489 460477 56769 70410709
Hallucination, auditory 16.64 9.99 62 460904 18266 70449212
Cardiotoxicity 16.60 9.99 29 460937 11041 70456437
Hemiparesis 16.54 9.99 128 460838 31341 70436137
Weight decreased 16.53 9.99 2281 458685 308207 70159271
Graft versus host disease in skin 16.43 9.99 8 460958 5622 70461856
Visual acuity reduced 16.43 9.99 110 460856 27820 70439658
Skin necrosis 16.38 9.99 170 460796 16121 70451357
Dysphagia 16.38 9.99 584 460382 112250 70355228
Lacrimal disorder 16.33 9.99 18 460948 473 70467005
Haematoma 16.30 9.99 219 460747 48199 70419279
Cytomegalovirus chorioretinitis 16.28 9.99 7 460959 5291 70462187
Coronary arterial stent insertion 16.24 9.99 9 460957 5878 70461600
Pneumatosis intestinalis 16.24 9.99 9 460957 5878 70461600
Pseudomonas infection 16.12 9.99 66 460900 18928 70448550
Lung transplant 16.12 9.99 4 460962 4286 70463192
Foetal exposure during pregnancy 16.04 9.99 76 460890 5569 70461909
Body height below normal 16.02 9.99 37 460929 1858 70465620
Amylase increased 15.99 9.99 26 460940 10182 70457296
Polyuria 15.99 9.99 40 460926 13366 70454112
Heart rate irregular 15.97 9.99 277 460689 29466 70438012
Haemorrhage in pregnancy 15.96 9.99 30 460936 1301 70466177
Myocardial ischaemia 15.95 9.99 92 460874 24108 70443370
Unevaluable event 15.94 9.99 240 460726 51823 70415655
Placental disorder 15.94 9.99 24 460942 866 70466612
Prostatic specific antigen increased 15.89 9.99 23 460943 9443 70458035
Hypoalbuminaemia 15.89 9.99 67 460899 19055 70448423
Acute lymphocytic leukaemia recurrent 15.85 9.99 6 460960 4898 70462580
Encephalitis toxic 15.83 9.99 14 460952 279 70467199
Atrioventricular block 15.81 9.99 37 460929 12651 70454827
Transplant dysfunction 15.79 9.99 13 460953 6896 70460582
Dystonia 15.79 9.99 70 460896 19636 70447842
Ankle arthroplasty 15.76 9.99 28 460938 1162 70466316
Pulmonary tuberculosis 15.74 9.99 96 460870 7749 70459729
Dry eye 15.69 9.99 296 460670 31986 70435492
Virologic failure 15.66 9.99 3 460963 3847 70463631
Myopathy 15.59 9.99 65 460901 18547 70448931
Spinal disorder 15.55 9.99 108 460858 9112 70458366
General physical health deterioration 15.53 9.99 1757 459209 234274 70233204
Tooth abscess 15.51 9.99 154 460812 14435 70453043
Persecutory delusion 15.51 9.99 5 460961 4512 70462966
Presyncope 15.43 9.99 162 460804 37276 70430202
Pulmonary haemorrhage 15.39 9.99 42 460924 13631 70453847
Dermatitis allergic 15.37 9.99 169 460797 16262 70451216
Respiratory acidosis 15.35 9.99 27 460939 10254 70457224
Deep vein thrombosis postoperative 15.35 9.99 55 460911 3552 70463926
Accidental exposure to product 15.26 9.99 113 460853 27938 70439540
Bladder cancer 15.21 9.99 59 460907 17183 70450295
Sickle cell anaemia 15.20 9.99 20 460946 635 70466843
Tuberculin test positive 15.12 9.99 51 460915 3195 70464283
Hypervolaemia 15.09 9.99 175 460791 39531 70427947
Kidney transplant rejection 15.02 9.99 26 460940 9935 70457543
Erectile dysfunction 15.01 9.99 42 460924 13520 70453958
Breast cancer stage II 15.00 9.99 8 460958 5338 70462140
Septic shock 14.96 9.99 587 460379 111671 70355807
Lymphatic fistula 14.94 9.99 22 460944 778 70466700
Complication of device insertion 14.93 9.99 8 460958 5324 70462154
Alanine aminotransferase increased 14.84 9.99 795 460171 146685 70320793
Delusion 14.80 9.99 69 460897 19096 70448382
Femoral hernia incarcerated 14.79 9.99 22 460944 785 70466693
Memory impairment 14.72 9.99 474 460492 92167 70375311
Chills 14.66 9.99 780 460186 144006 70323472
Kidney infection 14.65 9.99 192 460774 19263 70448215
Drug screen positive 14.62 9.99 10 460956 5830 70461648
Lip swelling 14.59 9.99 146 460820 33908 70433570
Wound infection pseudomonas 14.59 9.99 32 460934 1552 70465926
Genital haemorrhage 14.50 9.99 10 460956 5805 70461673
Viral mutation identified 14.36 9.99 3 460963 3619 70463859
Purpura 14.31 9.99 64 460902 17911 70449567
Device leakage 14.31 9.99 24 460942 9284 70458194
Intracranial pressure increased 14.30 9.99 16 460950 7340 70460138
Hypertriglyceridaemia 14.28 9.99 35 460931 11776 70455702
Upper respiratory tract infection 14.26 9.99 641 460325 78633 70388845
Foot operation 14.25 9.99 66 460900 4791 70462687
Radiation inflammation 14.21 9.99 18 460948 550 70466928
Finger deformity 14.21 9.99 78 460888 6058 70461420
Device related infection 14.20 9.99 137 460829 32048 70435430
Multiple sclerosis 14.17 9.99 101 460865 25184 70442294
Mass 14.16 9.99 163 460803 15863 70451615
Joint lock 14.16 9.99 47 460919 2920 70464558
Eosinophil count increased 14.14 9.99 51 460915 15171 70452307
Cholangitis 14.14 9.99 34 460932 11515 70455963
Bradypnoea 14.13 9.99 9 460957 5450 70462028
Urinary retention 14.12 9.99 248 460718 52272 70415206
Abdominal distension 14.02 9.99 547 460419 104122 70363356
Pneumonia bacterial 14.01 9.99 58 460908 16583 70450895
Cervical incompetence 14.00 9.99 17 460949 497 70466981
Injection site urticaria 13.94 9.99 126 460840 11512 70455966
Placental insufficiency 13.93 9.99 25 460941 1046 70466432
Obesity 13.90 9.99 248 460718 26523 70440955
Deformity 13.88 9.99 97 460869 8200 70459278
Normal newborn 13.87 9.99 79 460887 6221 70461257
Bone density abnormal 13.87 9.99 46 460920 2857 70464621
Obstructive airways disorder 13.83 9.99 106 460860 26007 70441471
Dry skin 13.83 9.99 268 460698 55663 70411815
Serum ferritin increased 13.75 9.99 103 460863 8902 70458576
Anger 13.73 9.99 56 460910 16076 70451402
COVID-19 pneumonia 13.70 9.99 85 460881 21884 70445594
Knee operation 13.66 9.99 67 460899 4980 70462498
Hyperlactacidaemia 13.64 9.99 8 460958 5064 70462414
Maternal exposure during breast feeding 13.62 9.99 39 460927 2235 70465243
Tooth disorder 13.60 9.99 225 460741 23713 70443765
Delivery 13.60 9.99 18 460948 575 70466903
Blood urea increased 13.59 9.99 213 460753 45696 70421782
Uterine perforation 13.57 9.99 11 460955 5880 70461598
Spinal osteoarthritis 13.52 9.99 156 460810 15192 70452286
Osteopenia 13.51 9.99 167 460799 16530 70450948
Paranoia 13.50 9.99 62 460904 17226 70450252
Tooth infection 13.47 9.99 165 460801 16298 70451180
Drug abuser 13.44 9.99 11 460955 5853 70461625
Skin neoplasm excision 13.42 9.99 23 460943 927 70466551
Respiratory tract infection viral 13.40 9.99 52 460914 3489 70463989
Peritoneal dialysis complication 13.39 9.99 39 460927 2257 70465221
Acidosis 13.38 9.99 67 460899 18196 70449282
Aphthous ulcer 13.37 9.99 150 460816 14506 70452972
Jaundice 13.35 9.99 237 460729 49871 70417607
Abortion threatened 13.35 9.99 15 460951 403 70467075
Human anti-human antibody test 13.29 9.99 15 460951 405 70467073
Hypercapnia 13.25 9.99 21 460945 8308 70459170
Frequent bowel movements 13.22 9.99 202 460764 20951 70446527
Ventricular arrhythmia 13.17 9.99 19 460947 7811 70459667
Ileus paralytic 13.09 9.99 23 460943 8738 70458740
Injection site haemorrhage 13.08 9.99 236 460730 25291 70442187
Immune thrombocytopenia 13.07 9.99 58 460908 16266 70451212
Immunosuppression 13.05 9.99 123 460843 11369 70456109
Arthritis bacterial 13.05 9.99 95 460871 8138 70459340
Generalised oedema 13.02 9.99 85 460881 21623 70445855
Strongyloidiasis 13.00 9.99 4 460962 3719 70463759
Hypothyroidism 12.97 9.99 214 460752 45541 70421937
Haemodynamic instability 12.92 9.99 55 460911 15603 70451875
Gestational hypertension 12.92 9.99 33 460933 1767 70465711
Joint warmth 12.92 9.99 30 460936 1512 70465966
Ankylosing spondylitis 12.91 9.99 124 460842 11522 70455956
Hepatitis E antibody positive 12.90 9.99 12 460954 256 70467222
Antibody test positive 12.90 9.99 41 460925 2490 70464988
Salivary hypersecretion 12.89 9.99 42 460924 12883 70454595
Pancreatic steatosis 12.84 9.99 24 460942 1036 70466442
Blood glucose decreased 12.82 9.99 98 460868 24061 70443417
Oesophageal carcinoma 12.76 9.99 26 460940 9340 70458138
Iodine allergy 12.75 9.99 17 460949 547 70466931
Systemic inflammatory response syndrome 12.75 9.99 32 460934 10680 70456798
Red blood cell count decreased 12.73 9.99 436 460530 51725 70415753
Pneumothorax 12.72 9.99 107 460859 25739 70441739
Starvation ketoacidosis 12.71 9.99 9 460957 128 70467350
Renal cancer 12.71 9.99 37 460929 11759 70455719
Blood folate increased 12.70 9.99 16 460950 486 70466992
Pleural fibrosis 12.70 9.99 57 460909 4082 70463396
Hepatitis cholestatic 12.69 9.99 41 460925 12609 70454869
Type 1 diabetes mellitus 12.65 9.99 13 460953 6201 70461277
Stress at work 12.64 9.99 24 460942 1049 70466429
Personality change 12.62 9.99 24 460942 8846 70458632
Glomerular filtration rate decreased 12.58 9.99 81 460885 20675 70446803
Schizophrenia 12.58 9.99 61 460905 16707 70450771
Lower respiratory tract congestion 12.57 9.99 49 460917 3295 70464183
Therapy non-responder 12.57 9.99 616 460350 76299 70391179
Complications of transplanted kidney 12.56 9.99 12 460954 5922 70461556
Mental disorder 12.55 9.99 120 460846 28120 70439358
Anti-neutrophil cytoplasmic antibody positive vasculitis 12.53 9.99 3 460963 3294 70464184
Arthropod bite 12.52 9.99 86 460880 7229 70460249
Coronary artery bypass 12.49 9.99 12 460954 5908 70461570
Small for dates baby 12.48 9.99 15 460951 434 70467044
Oesophageal fibrosis 12.34 9.99 10 460956 176 70467302
Clear cell renal cell carcinoma 12.30 9.99 38 460928 2272 70465206
Osteoporotic fracture 12.29 9.99 53 460913 3731 70463747
Accidental death 12.27 9.99 5 460961 3903 70463575
Hepatic cancer 12.26 9.99 28 460938 9655 70457823
Diaphragmatic disorder 12.23 9.99 30 460936 1566 70465912
Multiple-drug resistance 12.22 9.99 18 460948 7337 70460141
Muscle twitching 12.21 9.99 77 460889 19750 70447728
Metastasis 12.21 9.99 13 460953 6101 70461377
Breast abscess 12.20 9.99 26 460940 1236 70466242
Hepatitis acute 12.18 9.99 48 460918 13914 70453564
Anal fistula 12.12 9.99 74 460892 5976 70461502
Osteonecrosis 12.09 9.99 126 460840 29034 70438444
Atrioventricular block complete 12.06 9.99 54 460912 15109 70452369
Drug specific antibody 12.02 9.99 38 460928 2301 70465177
Personality disorder 12.00 9.99 11 460955 5537 70461941
Multiple drug therapy 11.94 9.99 3 460963 3189 70464289
Drug tolerance 11.94 9.99 86 460880 7342 70460136
Umbilical hernia 11.87 9.99 66 460900 5150 70462328
Cholestasis of pregnancy 11.82 9.99 22 460944 947 70466531
Acute graft versus host disease in intestine 11.79 9.99 5 460961 3811 70463667
Neck pain 11.77 9.99 538 460428 66119 70401359
Product prescribing error 11.77 9.99 180 460786 38772 70428706
Bone marrow failure 11.76 9.99 236 460730 48774 70418704
Nephrotic syndrome 11.74 9.99 33 460933 10607 70456871
Brain natriuretic peptide increased 11.72 9.99 22 460944 8149 70459329
Renal disorder 11.71 9.99 175 460791 37834 70429644
Tooth fracture 11.70 9.99 113 460853 10514 70456964
Catheter site erythema 11.70 9.99 9 460957 4939 70462539
Polydipsia 11.66 9.99 13 460953 5975 70461503
Labyrinthitis 11.64 9.99 42 460924 2722 70464756
Nail injury 11.60 9.99 16 460950 532 70466946
Heparin-induced thrombocytopenia 11.55 9.99 26 460940 9011 70458467
Sarcopenia 11.54 9.99 14 460952 409 70467069
Immune-mediated myositis 11.52 9.99 3 460963 3113 70464365
Toothache 11.51 9.99 176 460790 18254 70449224
Drug hypersensitivity 11.48 9.99 1512 459454 260947 70206531
Plasma cell myeloma recurrent 11.48 9.99 7 460959 4339 70463139
Sensitivity to weather change 11.48 9.99 85 460881 7320 70460158
Plasmacytoma 11.47 9.99 6 460960 4048 70463430
Epilepsy 11.46 9.99 180 460786 38604 70428874
Haemodialysis 11.46 9.99 66 460900 17300 70450178
Myofascial pain syndrome 11.44 9.99 32 460934 1810 70465668
Transaminases increased 11.41 9.99 226 460740 46792 70420686
Renal tubular necrosis 11.37 9.99 96 460870 23075 70444403
Defaecation disorder 11.36 9.99 17 460949 610 70466868
Sinus congestion 11.28 9.99 167 460799 17206 70450272
Dementia 11.28 9.99 92 460874 22273 70445205
Jaundice cholestatic 11.27 9.99 27 460939 9157 70458321
Angina unstable 11.25 9.99 59 460907 15834 70451644
Intervertebral disc degeneration 11.24 9.99 139 460827 13761 70453717
Abortion incomplete 11.22 9.99 3 460963 3059 70464419
C-reactive protein decreased 11.21 9.99 38 460928 2386 70465092
Tendon disorder 11.20 9.99 77 460889 6474 70461004
Hepatitis C 11.19 9.99 44 460922 12763 70454715
Sleep disorder due to a general medical condition 11.19 9.99 33 460933 10443 70457035
Vascular device infection 11.19 9.99 22 460944 8008 70459470
Acute myeloid leukaemia recurrent 11.18 9.99 3 460963 3051 70464427
Mycobacterium tuberculosis complex test positive 11.17 9.99 37 460929 2296 70465182
Device dislocation 11.16 9.99 93 460873 22414 70445064
Postpartum haemorrhage 11.16 9.99 28 460938 1483 70465995
Injection site extravasation 11.16 9.99 96 460870 8650 70458828
Cystitis 11.11 9.99 391 460575 46550 70420928
Hypoxic-ischaemic encephalopathy 11.09 9.99 19 460947 7289 70460189
Incoherent 11.08 9.99 19 460947 7287 70460191
Liver injury 11.04 9.99 347 460619 40688 70426790
Skin ulcer haemorrhage 11.03 9.99 15 460951 492 70466986
Hepatocellular carcinoma 11.01 9.99 32 460934 10176 70457302
Toxic encephalopathy 10.95 9.99 33 460933 10373 70457105
Upper respiratory tract inflammation 10.91 9.99 6 460960 3936 70463542
Laryngospasm 10.90 9.99 5 460961 3638 70463840
Threatened labour 10.90 9.99 16 460950 564 70466914
Product preparation error 10.89 9.99 8 460958 4494 70462984
Cytomegalovirus infection reactivation 10.88 9.99 17 460949 6764 70460714
Device occlusion 10.87 9.99 34 460932 10561 70456917
Eye infection 10.85 9.99 107 460859 10011 70457467
Skin exfoliation 10.83 9.99 237 460729 48389 70419089
Diabetes mellitus 10.82 9.99 370 460596 71454 70396024
Breast cancer metastatic 10.81 9.99 32 460934 10114 70457364
Parkinsonism 10.79 9.99 57 460909 15268 70452210
Crying 10.78 9.99 87 460879 21112 70446366
Vacuum extractor delivery 10.77 9.99 8 460958 123 70467355
Anticholinergic syndrome 10.77 9.99 3 460963 2977 70464501
Abortion missed 10.76 9.99 24 460942 1177 70466301
Hospitalisation 10.73 9.99 433 460533 82135 70385343
Hernia pain 10.73 9.99 14 460952 441 70467037
Hypertonia 10.70 9.99 16 460950 6482 70460996
Musculoskeletal discomfort 10.65 9.99 169 460797 17663 70449815
Therapy change 10.59 9.99 17 460949 6692 70460786
Cellulitis 10.59 9.99 763 460203 98165 70369313
Blood loss anaemia 10.57 9.99 53 460913 14388 70453090
Hydrocephalus 10.54 9.99 23 460943 8062 70459416
Aptyalism 10.53 9.99 18 460948 724 70466754
Swollen joint count 10.53 9.99 21 460945 952 70466526
Hernia 10.51 9.99 145 460821 14715 70452763
Anal fissure 10.50 9.99 73 460893 6160 70461318
Photophobia 10.49 9.99 175 460791 18475 70449003
COVID-19 10.47 9.99 571 460395 105186 70362292
Skin graft failure 10.46 9.99 10 460956 221 70467257
Oxygen consumption increased 10.46 9.99 9 460957 4671 70462807
Diabetes insipidus 10.42 9.99 9 460957 4662 70462816
Mitochondrial toxicity 10.39 9.99 3 460963 2907 70464571
Ligament rupture 10.37 9.99 42 460924 2875 70464603
Chondropathy 10.29 9.99 37 460929 2393 70465085
Failure to anastomose 10.28 9.99 10 460956 226 70467252
Hepatitis E virus test positive 10.26 9.99 11 460955 280 70467198
Panic attack 10.25 9.99 93 460873 22026 70445452
Cirrhosis alcoholic 10.25 9.99 21 460945 971 70466507
Lymphopenia 10.24 9.99 121 460845 27238 70440240
Bundle branch block left 10.23 9.99 34 460932 10365 70457113
Increased tendency to bruise 10.23 9.99 102 460864 9573 70457905
Complication associated with device 10.21 9.99 60 460906 15653 70451825
Injection site discolouration 10.21 9.99 80 460886 7012 70460466
Disturbance in social behaviour 10.13 9.99 7 460959 4060 70463418
Motor dysfunction 10.13 9.99 47 460919 13023 70454455
Mesothelioma 10.12 9.99 12 460954 342 70467136
Insomnia 10.11 9.99 1250 459716 216556 70250922
Hyperpyrexia 10.11 9.99 12 460954 5362 70462116
Hypoventilation 10.09 9.99 17 460949 6565 70460913
Atrial flutter 10.07 9.99 84 460882 20243 70447235
Cross sensitivity reaction 10.06 9.99 5 460961 3473 70464005
Pseudomembranous colitis 10.06 9.99 11 460955 5100 70462378
Benign ovarian tumour 10.04 9.99 11 460955 287 70467191
Product administered to patient of inappropriate age 10.01 9.99 10 460956 4833 70462645
Hypophysitis 10.00 9.99 6 460960 3752 70463726

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11DA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12
Vitamin B1, plain
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:71692 insect repellents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Korsakoff's psychosis indication 69482004 DOID:10915
Pernicious anemia indication 84027009 DOID:13381
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Cobalamin deficiency indication 190634004
Thiamin deficiency indication 399357009 DOID:0070313
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Prevention of Vitamin B12 Deficiency indication
Methylmalonic acidemia off-label use 42393006
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Agoraphobia contraindication 70691001 DOID:593
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Panic disorder contraindication 371631005 DOID:594
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thiamine transporter 1 Transporter WOMBAT-PK
Transketolase Enzyme WOMBAT-PK
Thiamin pyrophosphokinase 1 Kinase WOMBAT-PK
Thiamine-triphosphatase Enzyme WOMBAT-PK
Transketolase-like protein 1 Enzyme WOMBAT-PK
Heat shock protein HSP 90-alpha Cytosolic other IC50 4.90 CHEMBL
Thiamine transporter ThiT Transporter Kd 9.91 CHEMBL

External reference:

IDSource
4017777 VUID
N0000146138 NUI
D08580 KEGG_DRUG
67-03-8 SECONDARY_CAS_RN
532-43-4 SECONDARY_CAS_RN
4017446 VANDF
4017474 VANDF
4017634 VANDF
4017777 VANDF
4021900 VANDF
C0039840 UMLSCUI
CHEBI:26948 CHEBI
VIB PDB_CHEM_ID
CHEMBL1547 ChEMBL_ID
CHEMBL1588 ChEMBL_ID
CHEMBL1200941 ChEMBL_ID
DB00152 DRUGBANK_ID
CHEMBL2104496 ChEMBL_ID
D013831 MESH_DESCRIPTOR_UI
C000712172 MESH_SUPPLEMENTAL_RECORD_UI
1130 PUBCHEM_CID
4629 IUPHAR_LIGAND_ID
432 INN_ID
X66NSO3N35 UNII
10454 RXNORM
1096 MMSL
15466 MMSL
41397 MMSL
5566 MMSL
5681 MMSL
7276 MMSL
d03130 MMSL
001061 NDDF
001062 NDDF
003860 NDDF
126228004 SNOMEDCT_US
126229007 SNOMEDCT_US
259659006 SNOMEDCT_US
30306003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 2 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 4.54 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 4.54 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 3 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 3 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 3 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 3 mg ORAL Unapproved drug other 11 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9963 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 11 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9963 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 11 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9963 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 11 sections
Thiamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0641-6228 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 15 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1.60 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1.10 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1.60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.60 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 20 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1.60 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 3 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 1.50 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections