thiamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2832 59-43-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiamine
  • vitamin B1
  • thiamine hydrochloride
  • thiamine mononitrate
  • thiamine (vit B1)
  • thiamine HCl
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.
  • Molecular weight: 265.35
  • Formula: C12H17N4OS
  • CLOGP: -5.67
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.91
  • ALOGS: -4.29
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O
50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 27 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.55 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 4.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1993 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1574.16 10.10 3081 383412 117085 50101546
Systemic lupus erythematosus 1462.31 10.10 3280 383213 137342 50081289
Glossodynia 1258.93 10.10 2747 383746 112822 50105809
Rheumatoid arthritis 1021.36 10.10 3633 382860 198917 50019714
Hand deformity 1001.55 10.10 2302 384191 97897 50120734
Maternal exposure during pregnancy 903.16 10.10 2978 383515 156800 50061831
Arthropathy 901.42 10.10 2953 383540 154953 50063678
Alopecia 884.43 10.10 3959 382534 241088 49977543
Abdominal discomfort 862.77 10.10 3778 382715 227863 49990768
Wound 817.17 10.10 2203 384290 103591 50115040
Completed suicide 728.31 10.10 79 386414 131810 50086821
Infusion related reaction 643.18 10.10 2782 383711 166775 50051856
Synovitis 642.48 10.10 2244 384249 121621 50097010
Pericarditis 620.88 10.10 1652 384841 77037 50141594
Anti-cyclic citrullinated peptide antibody positive 611.58 10.10 1535 384958 69052 50149579
Contraindicated product administered 593.42 10.10 2481 384012 146477 50072154
Discomfort 582.46 10.10 1987 384506 106393 50112238
Swelling 561.05 10.10 3018 383475 197854 50020777
Joint swelling 546.91 10.10 3472 383021 241814 49976817
Toxicity to various agents 546.59 10.10 491 386002 212008 50006623
Pain 528.81 10.10 6737 379756 572166 49646465
Death 449.72 10.10 1152 385341 324227 49894404
Product use issue 377.13 10.10 2186 384307 147289 50071342
Rheumatoid factor positive 373.26 10.10 1027 385466 48832 50169799
Duodenal ulcer perforation 351.91 10.10 950 385543 44661 50173970
Arthralgia 344.82 10.10 4973 381520 433729 49784902
Helicobacter infection 340.05 10.10 991 385502 48711 50169920
Drug abuse 324.78 10.10 38 386455 59808 50158823
Drug interaction 319.75 10.10 652 385841 198969 50019662
Hepatic enzyme increased 305.12 10.10 1944 384549 135436 50083195
Intentional overdose 301.60 10.10 56 386437 62448 50156183
Exposure during pregnancy 284.68 10.10 1738 384755 119277 50099354
Musculoskeletal stiffness 240.99 10.10 1744 384749 126737 50091894
Hip arthroplasty 237.91 10.10 637 385856 29792 50188839
Drug intolerance 231.87 10.10 2626 383867 216478 50002153
Therapeutic product effect decreased 225.55 10.10 1794 384699 134256 50084375
Treatment failure 221.15 10.10 1802 384691 135835 50082796
Knee arthroplasty 218.14 10.10 686 385807 35160 50183471
Febrile neutropenia 210.10 10.10 262 386231 97405 50121226
Overdose 196.80 10.10 285 386208 99442 50119189
Psoriatic arthropathy 183.47 10.10 779 385714 46253 50172378
Nasopharyngitis 178.41 10.10 2254 384239 190673 50027958
Suicide attempt 173.57 10.10 89 386404 51643 50166988
Depressed level of consciousness 171.91 10.10 91 386402 51862 50166769
Red blood cell sedimentation rate abnormal 161.33 10.10 374 386119 15969 50202662
Acute kidney injury 158.95 10.10 1054 385439 227004 49991627
Malignant neoplasm progression 158.06 10.10 172 386321 67952 50150679
Drug hypersensitivity 156.51 10.10 1198 385295 249812 49968819
Cardiac arrest 155.45 10.10 249 386244 83402 50135229
Hypersensitivity 152.32 10.10 2398 384095 212763 50005868
Device expulsion 152.21 10.10 20 386473 28802 50189829
Disease progression 145.88 10.10 322 386171 95544 50123087
C-reactive protein abnormal 144.90 10.10 505 385988 27304 50191327
Nausea 139.79 10.10 4215 382278 701183 49517448
Constipation 139.27 10.10 839 385654 184869 50033762
Impaired healing 138.71 10.10 961 385532 68825 50149806
Diarrhoea 137.77 10.10 3434 383059 585042 49633589
Rheumatic fever 134.77 10.10 356 386137 16511 50202120
Swollen joint count increased 130.30 10.10 325 386168 14548 50204083
Sickle cell anaemia with crisis 128.57 10.10 166 386327 4377 50214254
Neutropenia 128.22 10.10 637 385856 147328 50071303
Lactic acidosis 121.77 10.10 51 386442 33304 50185327
Bradycardia 119.48 10.10 192 386301 64234 50154397
Drug ineffective 118.85 10.10 7505 378988 811828 49406803
Cardiac failure 118.50 10.10 252 386241 75788 50142843
Sedation 116.34 10.10 44 386449 30566 50188065
Asthenia 116.16 10.10 1726 384767 317316 49901315
Anxiety 112.34 10.10 844 385649 176762 50041869
Tremor 109.98 10.10 477 386016 114426 50104205
Hypotension 109.35 10.10 1210 385283 234259 49984372
Dyspnoea 105.53 10.10 3283 383210 544325 49674306
Pregnancy 104.02 10.10 475 386018 29102 50189529
Somnolence 102.08 10.10 728 385765 154257 50064374
Dizziness 101.29 10.10 1950 384543 344419 49874212
Psoriasis 100.95 10.10 885 385608 68115 50150516
Renal failure 100.63 10.10 445 386048 106188 50112443
Respiratory arrest 100.10 10.10 52 386441 29957 50188674
Vomiting 99.31 10.10 2720 383773 458038 49760593
Fatigue 96.12 10.10 6447 380046 701154 49517477
Sleep disorder due to general medical condition, insomnia type 95.40 10.10 484 386009 30963 50187668
Live birth 94.33 10.10 308 386185 16100 50202531
Muscle injury 93.54 10.10 543 385950 36568 50182063
Sopor 93.36 10.10 19 386474 19860 50198771
Arthritis 92.23 10.10 1041 385452 85680 50132951
Folliculitis 91.87 10.10 563 385930 38662 50179969
Rash 91.04 10.10 4147 382346 433324 49785307
Agitation 90.84 10.10 168 386325 53216 50165415
Multiple sclerosis relapse 90.54 10.10 117 386376 42847 50175784
Osteoarthritis 89.75 10.10 859 385634 67747 50150884
Neoplasm progression 89.42 10.10 56 386437 29101 50189530
Abortion spontaneous 88.82 10.10 585 385908 41187 50177444
Intentional self-injury 88.21 10.10 33 386460 23079 50195552
Lower respiratory tract infection 88.16 10.10 1113 385380 94088 50124543
Rhabdomyolysis 87.82 10.10 101 386392 38926 50179705
Hyponatraemia 86.66 10.10 408 386085 95731 50122900
Blister 85.76 10.10 1014 385479 84404 50134227
Drug reaction with eosinophilia and systemic symptoms 85.24 10.10 56 386437 28368 50190263
Injection site erythema 79.89 10.10 900 385593 74036 50144595
Insomnia 78.98 10.10 904 385589 173961 50044670
Syncope 77.32 10.10 465 386028 102537 50116094
Cardio-respiratory arrest 77.13 10.10 187 386306 53705 50164926
Condition aggravated 76.29 10.10 2880 383613 294178 49924453
Hyperhidrosis 76.26 10.10 387 386106 89039 50129592
Electrocardiogram QT prolonged 75.88 10.10 178 386315 51708 50166923
Product quality issue 74.84 10.10 75 386418 30783 50187848
Drug withdrawal syndrome 74.42 10.10 50 386443 25031 50193600
Blood pressure fluctuation 72.15 10.10 495 385998 35328 50183303
Myalgia 71.07 10.10 607 385886 123712 50094919
Tachycardia 70.43 10.10 459 386034 99304 50119327
Neuropathy peripheral 69.41 10.10 443 386050 96314 50122317
Drug dependence 69.30 10.10 32 386461 19727 50198904
Hypoglycaemia 67.53 10.10 198 386295 53383 50165248
Joint effusion 67.42 10.10 236 386257 12785 50205846
Irritable bowel syndrome 66.73 10.10 643 385850 50798 50167833
Serotonin syndrome 65.95 10.10 55 386438 24658 50193973
Injection site pruritus 65.82 10.10 531 385962 39880 50178751
Palmar-plantar erythrodysaesthesia syndrome 65.31 10.10 36 386457 20062 50198569
Anaemia 65.19 10.10 1450 385043 251006 49967625
Hypoxia 65.10 10.10 188 386305 50935 50167696
Hyperglycaemia 63.33 10.10 113 386380 36292 50182339
Caesarean section 63.27 10.10 262 386231 15377 50203254
Cognitive disorder 62.43 10.10 154 386339 43969 50174662
Intentional product misuse 62.37 10.10 168 386325 46566 50172065
Asthma 62.06 10.10 413 386080 88924 50129707
Disability assessment scale score increased 61.84 10.10 83 386410 2275 50216356
Juvenile idiopathic arthritis 61.67 10.10 92 386401 2787 50215844
Basal cell carcinoma 61.65 10.10 346 386147 23010 50195621
Cardiac failure congestive 60.69 10.10 386 386107 83996 50134635
Drug resistance 60.29 10.10 35 386458 18954 50199677
Hepatic function abnormal 60.01 10.10 98 386395 32583 50186048
Renal impairment 59.75 10.10 336 386157 75325 50143306
Urticaria 59.57 10.10 667 385826 128894 50089737
Feeling abnormal 57.71 10.10 646 385847 124846 50093785
Encephalopathy 57.43 10.10 106 386387 33605 50185026
No adverse event 56.83 10.10 106 386387 33472 50185159
Diabetic ketoacidosis 56.66 10.10 33 386460 17839 50200792
Foot deformity 56.41 10.10 293 386200 18917 50199714
Red blood cell sedimentation rate increased 56.03 10.10 401 386092 29015 50189616
Sinusitis 55.99 10.10 1702 384791 168856 50049775
Contusion 55.58 10.10 1183 385310 111000 50107631
Joint laxity 54.80 10.10 79 386414 2319 50216312
Cholestasis 54.73 10.10 68 386425 25333 50193298
Sedation complication 54.64 10.10 3 386490 8763 50209868
Thrombocytopenia 54.55 10.10 668 385825 127005 50091626
Respiratory failure 54.46 10.10 440 386053 90741 50127890
Pulmonary embolism 53.99 10.10 506 385987 101198 50117433
Injection site reaction 53.81 10.10 602 385891 49430 50169201
Multiple organ dysfunction syndrome 53.79 10.10 200 386293 50137 50168494
Premature labour 53.49 10.10 201 386292 11275 50207356
Fluid retention 52.98 10.10 203 386290 50446 50168185
Hepatic failure 52.81 10.10 104 386389 32179 50186452
Orthostatic hypotension 52.65 10.10 90 386403 29391 50189240
Blood cholesterol increased 52.15 10.10 648 385845 54567 50164064
Chest discomfort 51.96 10.10 455 386038 92267 50126364
Muscle spasms 51.73 10.10 662 385831 124891 50093740
Coma 51.46 10.10 241 386252 56638 50161993
Blood glucose increased 50.91 10.10 327 386166 70997 50147634
Ill-defined disorder 50.58 10.10 639 385854 54015 50164616
Respiratory disorder 50.56 10.10 101 386392 31086 50187545
Blood pressure diastolic abnormal 50.50 10.10 172 386321 9189 50209442
Injection site swelling 50.22 10.10 514 385979 41259 50177372
Vision blurred 50.01 10.10 373 386120 78274 50140357
Muscle spasticity 49.99 10.10 35 386458 17149 50201482
Balance disorder 49.70 10.10 325 386168 70265 50148366
Metastases to bone 49.32 10.10 39 386454 17956 50200675
Metabolic acidosis 49.27 10.10 143 386350 38682 50179949
Osteoporosis 49.18 10.10 542 385951 44337 50174294
Altered state of consciousness 48.97 10.10 57 386436 21853 50196778
Hepatocellular injury 48.40 10.10 77 386416 25870 50192761
Mydriasis 48.19 10.10 11 386482 10616 50208015
Foetal exposure during pregnancy 48.14 10.10 366 386127 26993 50191638
Cytomegalovirus infection 47.90 10.10 40 386453 17922 50200709
Neutrophil count decreased 47.80 10.10 185 386308 45841 50172790
Injection site pain 47.56 10.10 1147 385346 109877 50108754
Grip strength decreased 47.43 10.10 201 386292 11920 50206711
Decreased appetite 47.10 10.10 1171 385322 199752 50018879
Fibromyalgia 46.93 10.10 538 385955 44440 50174191
Disturbance in attention 46.39 10.10 106 386387 31080 50187551
Peripheral swelling 46.37 10.10 1969 384524 203967 50014664
Pulmonary arterial hypertension 46.34 10.10 52 386441 20267 50198364
Emotional distress 46.32 10.10 93 386400 28570 50190061
Type 2 diabetes mellitus 46.23 10.10 433 386060 33942 50184689
Loss of consciousness 46.09 10.10 542 385951 103811 50114820
Dehydration 46.05 10.10 853 385640 151596 50067035
Bone erosion 45.88 10.10 194 386299 11493 50207138
Anaphylactic reaction 45.47 10.10 235 386258 53820 50164811
Loss of personal independence in daily activities 45.08 10.10 769 385724 69281 50149350
Product use in unapproved indication 45.04 10.10 618 385875 115201 50103430
Ejection fraction decreased 44.92 10.10 45 386448 18475 50200156
Restlessness 43.91 10.10 78 386415 25095 50193536
Poisoning 43.79 10.10 20 386473 12409 50206222
Seizure 43.35 10.10 636 385857 117238 50101393
Osteonecrosis of jaw 43.35 10.10 117 386376 32409 50186222
Depression 43.26 10.10 948 385545 164475 50054156
Hypokalaemia 43.24 10.10 446 386047 87546 50131085
Product administration error 43.22 10.10 52 386441 19647 50198984
Hallucination 43.21 10.10 196 386297 46461 50172170
White blood cell count decreased 43.20 10.10 629 385864 116093 50102538
Blood pressure systolic increased 43.00 10.10 437 386056 35012 50183619
Hypothermia 42.86 10.10 19 386474 11997 50206634
Blood pressure systolic abnormal 42.82 10.10 143 386350 7563 50211068
Gestational diabetes 42.79 10.10 140 386353 7325 50211306
Mental status changes 42.19 10.10 139 386354 36133 50182498
Neck deformity 42.07 10.10 63 386430 1915 50216716
Creatinine renal clearance decreased 42.04 10.10 19 386474 11862 50206769
Dyspnoea exertional 41.82 10.10 225 386268 51008 50167623
Multiple fractures 41.57 10.10 128 386365 6483 50212148
Maternal drugs affecting foetus 41.41 10.10 108 386385 4969 50213662
Extrapyramidal disorder 41.37 10.10 19 386474 11751 50206880
Leukopenia 41.17 10.10 324 386169 67204 50151427
Infection 40.59 10.10 1661 384832 171293 50047338
Blood pressure decreased 40.07 10.10 256 386237 55653 50162978
Hyperkalaemia 39.92 10.10 210 386283 47879 50170752
Pain in jaw 39.56 10.10 155 386338 38273 50180358
Tuberculosis 39.29 10.10 167 386326 9916 50208715
Respiratory depression 38.32 10.10 22 386471 11988 50206643
Speech disorder 38.14 10.10 141 386352 35407 50183224
Blood creatine phosphokinase increased 38.11 10.10 91 386402 26276 50192355
Weight increased 38.02 10.10 1896 384597 199995 50018636
Rheumatoid nodule 37.91 10.10 195 386298 12540 50206091
Shock 37.84 10.10 62 386431 20588 50198043
Cerebral haemorrhage 37.81 10.10 95 386398 26957 50191674
Hospitalisation 37.34 10.10 335 386158 67602 50151029
Metastases to liver 37.18 10.10 60 386433 20044 50198587
Suicidal ideation 36.98 10.10 259 386234 55126 50163505
Deep vein thrombosis 36.66 10.10 370 386123 72934 50145697
Pre-eclampsia 35.94 10.10 139 386354 7905 50210726
Dysgeusia 35.73 10.10 164 386329 38752 50179879
Platelet count decreased 35.48 10.10 548 385945 100178 50118453
Aspartate aminotransferase increased 35.26 10.10 403 386090 77595 50141036
Unresponsive to stimuli 35.12 10.10 118 386375 30491 50188140
Ventricular septal defect 35.07 10.10 88 386405 3953 50214678
Myocardial infarction 34.98 10.10 474 386019 88553 50130078
Brain oedema 34.94 10.10 26 386467 12344 50206287
Maternal exposure before pregnancy 34.85 10.10 108 386385 5489 50213142
Acute hepatic failure 34.80 10.10 41 386452 15636 50202995
Device dislocation 34.74 10.10 70 386423 21476 50197155
Disseminated intravascular coagulation 34.73 10.10 48 386445 17087 50201544
Memory impairment 34.73 10.10 413 386080 78947 50139684
Torsade de pointes 34.57 10.10 24 386469 11811 50206820
Delirium 34.44 10.10 162 386331 38030 50180601
Enthesopathy 34.37 10.10 127 386366 7066 50211565
Abnormal behaviour 34.21 10.10 61 386432 19597 50199034
Limb deformity 34.19 10.10 83 386410 3651 50214980
Palpitations 34.02 10.10 512 385981 93994 50124637
Angioedema 33.86 10.10 160 386333 37516 50181115
Polyarthritis 33.81 10.10 135 386358 7792 50210839
Anaphylactic shock 33.77 10.10 64 386429 20091 50198540
Blood bilirubin increased 33.77 10.10 128 386365 31910 50186721
Injection site bruising 33.64 10.10 429 386064 36339 50182292
Bone pain 33.46 10.10 217 386276 47012 50171619
Vertigo 33.34 10.10 245 386248 51587 50167044
Drug level increased 33.34 10.10 60 386433 19208 50199423
Blood pressure diastolic decreased 33.26 10.10 231 386262 16550 50202081
Localised infection 33.26 10.10 319 386174 25166 50193465
Flushing 33.20 10.10 339 386154 66676 50151955
Joint stiffness 33.19 10.10 366 386127 29942 50188689
Nodule 33.08 10.10 233 386260 16770 50201861
Tenderness 33.02 10.10 249 386244 18316 50200315
Ascites 33.00 10.10 151 386342 35710 50182921
Disorientation 32.89 10.10 149 386344 35335 50183296
Injection site rash 32.84 10.10 224 386269 15953 50202678
Gamma-glutamyltransferase increased 32.77 10.10 116 386377 29507 50189124
Blood calcium decreased 32.76 10.10 68 386425 20638 50197993
Accidental overdose 32.75 10.10 62 386431 19471 50199160
Akathisia 32.68 10.10 11 386482 8218 50210413
Infective pulmonary exacerbation of cystic fibrosis 32.42 10.10 10 386483 7899 50210732
Blood alkaline phosphatase increased 32.20 10.10 162 386331 37364 50181267
Wrong technique in product usage process 32.16 10.10 270 386223 55240 50163391
Posterior reversible encephalopathy syndrome 32.12 10.10 40 386453 14888 50203743
Pleural effusion 31.88 10.10 434 386059 81020 50137611
Joint destruction 31.63 10.10 83 386410 3833 50214798
Chest pain 31.58 10.10 1070 385423 175812 50042819
Femur fracture 31.31 10.10 430 386063 37034 50181597
Premature delivery 31.28 10.10 297 386196 23366 50195265
Pulmonary fibrosis 30.97 10.10 304 386189 24133 50194498
Diabetes mellitus inadequate control 30.68 10.10 33 386460 13112 50205519
Pulmonary oedema 30.68 10.10 233 386260 48705 50169926
Intentional product use issue 30.65 10.10 787 385706 76131 50142500
Chronic kidney disease 30.64 10.10 178 386315 39593 50179038
Dysphagia 30.35 10.10 413 386080 77105 50141526
Drug ineffective for unapproved indication 30.32 10.10 74 386419 21207 50197424
Arrhythmia 30.19 10.10 140 386353 32992 50185639
Small for dates baby 30.08 10.10 76 386417 3429 50215202
Premature rupture of membranes 30.04 10.10 90 386403 4490 50214141
Alanine aminotransferase increased 29.68 10.10 485 386008 87874 50130757
Haemorrhage 29.59 10.10 263 386230 53178 50165453
Disability 29.05 10.10 182 386311 12593 50206038
Tenosynovitis stenosans 29.00 10.10 57 386436 2167 50216464
Musculoskeletal pain 28.91 10.10 739 385754 71438 50147193
Latent tuberculosis 28.66 10.10 57 386436 2186 50216445
Smear cervix abnormal 28.46 10.10 64 386429 2677 50215954
Atrial fibrillation 28.36 10.10 577 385916 101168 50117463
Respiratory distress 28.28 10.10 128 386365 30361 50188270
C-reactive protein increased 28.22 10.10 686 385807 65788 50152843
Inflammation 28.11 10.10 600 385893 56312 50162319
Dysarthria 27.97 10.10 169 386324 37234 50181397
Synovial cyst 27.86 10.10 130 386363 8036 50210595
Toxic skin eruption 27.68 10.10 27 386466 11224 50207407
Device difficult to use 27.64 10.10 21 386472 9865 50208766
Withdrawal syndrome 27.63 10.10 58 386435 17532 50201099
Ventricular tachycardia 27.61 10.10 49 386444 15772 50202859
Heart rate decreased 27.36 10.10 411 386082 36086 50182545
International normalised ratio increased 27.26 10.10 205 386288 42947 50175684
Neurotoxicity 27.25 10.10 44 386449 14696 50203935
Cerebrovascular accident 26.66 10.10 536 385957 94144 50124487
Bradyphrenia 26.66 10.10 7 386486 6145 50212486
Pulmonary hypertension 26.59 10.10 148 386345 33269 50185362
Macular degeneration 26.55 10.10 43 386450 14345 50204286
Blood pressure diastolic increased 26.51 10.10 120 386373 7323 50211308
Joint range of motion decreased 26.31 10.10 236 386257 18276 50200355
Nightmare 26.15 10.10 52 386441 16034 50202597
Melaena 25.99 10.10 111 386382 26753 50191878
Irritability 25.97 10.10 120 386373 28306 50190325
Mania 25.93 10.10 27 386466 10889 50207742
Coagulopathy 25.88 10.10 62 386431 17882 50200749
Asphyxia 25.88 10.10 5 386488 5422 50213209
Stress cardiomyopathy 25.81 10.10 14 386479 7873 50210758
Wheelchair user 25.64 10.10 90 386403 4882 50213749
Tenosynovitis 25.59 10.10 153 386340 10412 50208219
Ischaemic stroke 25.55 10.10 52 386441 15896 50202735
Laryngitis 25.48 10.10 157 386336 10799 50207832
Thrombotic microangiopathy 25.45 10.10 18 386475 8773 50209858
Crying 25.32 10.10 76 386417 20340 50198291
Dysmorphism 25.24 10.10 53 386440 2114 50216517
Pyrexia 25.20 10.10 2531 383962 377672 49840959
Obstructive airways disorder 25.10 10.10 51 386442 15601 50203030
Psychotic disorder 25.08 10.10 84 386409 21728 50196903
Atrioventricular block complete 25.05 10.10 12 386481 7243 50211388
Bronchospasm 25.04 10.10 47 386446 14807 50203824
Pain in extremity 24.99 10.10 2414 384079 270451 49948180
Transplant rejection 24.89 10.10 22 386471 9587 50209044
Device use error 24.80 10.10 5 386488 5261 50213370
Oedema peripheral 24.70 10.10 971 385522 156990 50061641
Arthritis infective 24.69 10.10 96 386397 5473 50213158
Cytokine release syndrome 24.57 10.10 18 386475 8616 50210015
Polyneuropathy 24.57 10.10 34 386459 12097 50206534
Back pain 24.56 10.10 1402 385091 218628 50000003
Metastases to central nervous system 24.52 10.10 30 386463 11252 50207379
Developmental hip dysplasia 24.49 10.10 39 386454 1252 50217379
Parkinsonism 24.47 10.10 19 386474 8828 50209803
Accidental exposure to product 24.38 10.10 92 386401 22965 50195666
Febrile bone marrow aplasia 24.10 10.10 9 386484 6302 50212329
Dyskinesia 24.06 10.10 120 386373 27741 50190890
Skin papilloma 23.96 10.10 79 386414 4150 50214481
Neck mass 23.92 10.10 68 386425 3293 50215338
Drug tolerance decreased 23.71 10.10 135 386358 9025 50209606
Acute respiratory failure 23.71 10.10 126 386367 28656 50189975
Malignant melanoma 23.61 10.10 145 386348 9963 50208668
Paralysis 23.47 10.10 19 386474 8645 50209986
Eosinophilia 23.44 10.10 69 386424 18583 50200048
Graft versus host disease 23.20 10.10 9 386484 6157 50212474
Haematotoxicity 23.07 10.10 16 386477 7879 50210752
Oropharyngeal pain 23.03 10.10 767 385726 77034 50141597
Ventricular fibrillation 23.03 10.10 28 386465 10531 50208100
Second primary malignancy 23.03 10.10 12 386481 6902 50211729
Schizophrenia 22.97 10.10 14 386479 7383 50211248
Placental disorder 22.85 10.10 40 386453 1390 50217241
Inappropriate antidiuretic hormone secretion 22.67 10.10 41 386452 13102 50205529
Pancreatitis acute 22.67 10.10 99 386394 23713 50194918
Synovial fluid analysis 22.60 10.10 43 386450 1595 50217036
Sepsis 22.58 10.10 809 385684 132116 50086515
Skin ulcer 22.45 10.10 387 386106 34931 50183700
Complication of device insertion 22.43 10.10 9 386484 6032 50212599
Rotator cuff repair 22.40 10.10 44 386449 1672 50216959
Gastrointestinal haemorrhage 22.20 10.10 410 386083 72911 50145720
Abdominal distension 21.96 10.10 408 386085 72495 50146136
Panic attack 21.89 10.10 75 386418 19267 50199364
Aggression 21.84 10.10 85 386408 21031 50197600
Polyhydramnios 21.83 10.10 48 386445 1977 50216654
Acute myeloid leukaemia 21.80 10.10 52 386441 15022 50203609
Hypomania 21.80 10.10 4 386489 4501 50214130
Neuroleptic malignant syndrome 21.75 10.10 32 386461 11098 50207533
Pulmonary tuberculosis 21.74 10.10 77 386416 4196 50214435
Unevaluable event 21.61 10.10 236 386257 45830 50172801
Lupus-like syndrome 21.44 10.10 135 386358 9356 50209275
Muscular weakness 21.36 10.10 557 385936 94456 50124175
Blood potassium decreased 21.26 10.10 180 386313 36765 50181866
Metastases to lung 21.22 10.10 32 386461 10988 50207643
Agranulocytosis 21.04 10.10 88 386405 21333 50197298
Genital haemorrhage 21.04 10.10 12 386481 6562 50212069
Loose body in joint 21 10.10 35 386458 1168 50217463
Spinal stenosis 20.96 10.10 176 386317 13374 50205257
Miosis 20.94 10.10 11 386482 6299 50212332
Erythema multiforme 20.81 10.10 23 386470 9027 50209604
Blood creatinine increased 20.60 10.10 434 386059 75726 50142905
Tachypnoea 20.52 10.10 51 386442 14526 50204105
Cytopenia 20.52 10.10 22 386471 8753 50209878
Tumour lysis syndrome 20.44 10.10 16 386477 7405 50211226
Body temperature decreased 20.31 10.10 203 386290 16192 50202439
Face oedema 20.31 10.10 69 386424 17770 50200861
Acute graft versus host disease 20.30 10.10 3 386490 3955 50214676
Headache 20.19 10.10 3482 383011 503053 49715578
Uterine perforation 20.11 10.10 12 386481 6403 50212228
Postoperative wound infection 20.06 10.10 122 386371 8353 50210278
Cardiac failure acute 20.06 10.10 20 386473 8230 50210401
Anhedonia 19.99 10.10 26 386467 9498 50209133
Therapeutic response decreased 19.92 10.10 487 386006 46744 50171887
Injection site warmth 19.82 10.10 177 386316 13689 50204942
Stevens-Johnson syndrome 19.77 10.10 92 386401 21660 50196971
Foetal death 19.52 10.10 118 386375 8062 50210569
Stomatitis 19.51 10.10 954 385539 100390 50118241
Pancreatitis 19.32 10.10 220 386273 42394 50176237
Complication associated with device 19.31 10.10 53 386440 14602 50204029
Hemiparesis 19.30 10.10 83 386410 19965 50198666
Glycosylated haemoglobin increased 19.29 10.10 32 386461 10574 50208057
Substance abuse 19.24 10.10 4 386489 4120 50214511
Acute generalised exanthematous pustulosis 19.18 10.10 24 386469 8914 50209717
Product dose omission issue 19.15 10.10 1179 385314 182659 50035972
Maternal exposure timing unspecified 19.08 10.10 66 386427 3554 50215077
Product adhesion issue 19.03 10.10 5 386488 4387 50214244
Joint dislocation 18.97 10.10 160 386333 12173 50206458
Oedema 18.96 10.10 400 386093 69781 50148850
Gastroenteritis viral 18.83 10.10 223 386270 18563 50200068
Atrial septal defect 18.81 10.10 97 386396 6244 50212387
Disease recurrence 18.80 10.10 84 386409 19997 50198634
Abdominal pain 18.74 10.10 1551 384942 234677 49983954
Off label use 18.61 10.10 3264 383229 471162 49747469
Pemphigoid 18.59 10.10 11 386482 5896 50212735
Depressed mood 18.59 10.10 168 386325 33855 50184776
Acute chest syndrome 18.58 10.10 24 386469 633 50217998
Body height below normal 18.57 10.10 44 386449 1905 50216726
COVID-19 18.48 10.10 248 386245 46414 50172217
Shock haemorrhagic 18.33 10.10 22 386471 8322 50210309
Exposure to toxic agent 18.24 10.10 3 386490 3655 50214976
Synovial disorder 18.20 10.10 28 386465 872 50217759
Paradoxical drug reaction 18.17 10.10 3 386490 3644 50214987
Fear 18.16 10.10 54 386439 14495 50204136
Rash maculo-papular 18.07 10.10 124 386369 26517 50192114
Scleritis 18.03 10.10 60 386433 3167 50215464
Foetal anticonvulsant syndrome 17.93 10.10 22 386471 550 50218081
Sinus tachycardia 17.86 10.10 93 386400 21261 50197370
Fracture 17.85 10.10 202 386291 16631 50202000
Labelled drug-drug interaction medication error 17.79 10.10 33 386460 10444 50208187
Cholecystitis chronic 17.74 10.10 29 386464 9640 50208991
Red blood cell sedimentation rate 17.71 10.10 64 386429 3522 50215109
Hyperlipidaemia 17.71 10.10 71 386422 17419 50201212
Congenital arterial malformation 17.67 10.10 17 386476 320 50218311
Haemorrhage intracranial 17.65 10.10 43 386450 12331 50206300
Hypervolaemia 17.64 10.10 118 386375 25381 50193250
Nervousness 17.64 10.10 131 386362 27520 50191111
Bone marrow failure 17.56 10.10 131 386362 27493 50191138
Herpes zoster 17.55 10.10 684 385809 70102 50148529
Device related infection 17.51 10.10 90 386403 20645 50197986
Dementia 17.45 10.10 63 386430 15934 50202697
Plasma cell myeloma 17.40 10.10 154 386339 31168 50187463
Dystonia 17.36 10.10 41 386452 11885 50206746
Antinuclear antibody positive 17.27 10.10 94 386399 6178 50212453
Wheezing 17.24 10.10 352 386141 61695 50156936
Myopathy 17.16 10.10 27 386466 9112 50209519
Infusion site erythema 17.14 10.10 25 386468 8702 50209929
Clear cell renal cell carcinoma 17.12 10.10 32 386461 1171 50217460
Proteinuria 17.04 10.10 67 386426 16530 50202101
Mood altered 16.98 10.10 46 386447 12727 50205904
Joint noise 16.86 10.10 63 386430 3524 50215107
Multiple allergies 16.86 10.10 24 386469 8439 50210192
Haemorrhage in pregnancy 16.74 10.10 39 386454 1670 50216961
Haemophagocytic lymphohistiocytosis 16.69 10.10 25 386468 8608 50210023
Dactylitis 16.65 10.10 41 386452 1820 50216811
Crohn's disease 16.63 10.10 76 386417 4657 50213974
Cyst 16.63 10.10 154 386339 12033 50206598
Breast feeding 16.62 10.10 26 386467 822 50217809
Cushingoid 16.59 10.10 97 386396 6548 50212083
Atrioventricular block 16.58 10.10 15 386478 6463 50212168
Joint injury 16.57 10.10 246 386247 21543 50197088
Oral herpes 16.56 10.10 236 386257 20489 50198142
Status epilepticus 16.55 10.10 50 386443 13356 50205275
Fear of injection 16.49 10.10 91 386402 6012 50212619
Gestational hypertension 16.48 10.10 45 386448 2128 50216503
Haemoptysis 16.38 10.10 121 386372 25452 50193179
Lethargy 16.37 10.10 272 386221 49160 50169471
Immune reconstitution inflammatory syndrome 16.36 10.10 11 386482 5505 50213126
Incorrect route of product administration 16.35 10.10 80 386413 18586 50200045
Catheter site erythema 16.26 10.10 5 386488 3957 50214674
Hyperprolactinaemia 16.26 10.10 3 386490 3362 50215269
Temperature regulation disorder 16.19 10.10 6 386487 4221 50214410
Fracture delayed union 16.15 10.10 46 386447 2230 50216401
Lymphocyte count decreased 16.13 10.10 126 386367 26181 50192450
Aspergillus infection 16.06 10.10 17 386476 6804 50211827
Psychomotor hyperactivity 16.06 10.10 29 386464 9272 50209359
Salivary hypersecretion 16.00 10.10 16 386477 6575 50212056
Cardiogenic shock 16.00 10.10 63 386430 15536 50203095
Cholestasis of pregnancy 15.99 10.10 30 386463 1101 50217530
Hepatotoxicity 15.96 10.10 132 386361 27094 50191537
Tubulointerstitial nephritis 15.88 10.10 61 386432 15150 50203481
Hypertransaminasaemia 15.86 10.10 4 386489 3607 50215024
Poor venous access 15.83 10.10 134 386359 10206 50208425
Affective disorder 15.82 10.10 10 386483 5171 50213460
Complication of device removal 15.80 10.10 6 386487 4158 50214473
Talipes 15.79 10.10 34 386459 1380 50217251
Oliguria 15.69 10.10 24 386469 8192 50210439
Bronchopulmonary aspergillosis 15.66 10.10 21 386472 7571 50211060
Skin cancer 15.60 10.10 124 386369 9270 50209361
Stillbirth 15.59 10.10 88 386405 5864 50212767
Pharyngitis streptococcal 15.59 10.10 118 386375 8690 50209941
Dry skin 15.53 10.10 234 386259 42957 50175674
Aphasia 15.44 10.10 141 386352 28353 50190278
Cerebral infarction 15.43 10.10 99 386394 21505 50197126
Blood glucose decreased 15.40 10.10 79 386414 18132 50200499
Blood iron increased 15.40 10.10 33 386460 1335 50217296
Pulmonary congestion 15.37 10.10 62 386431 15185 50203446
Respiration abnormal 15.37 10.10 10 386483 5092 50213539
Exomphalos 15.33 10.10 20 386473 533 50218098
Anuria 15.32 10.10 40 386453 11204 50207427
Diabetes mellitus 15.21 10.10 273 386220 48760 50169871
Dislocation of vertebra 15.17 10.10 55 386438 3032 50215599
Tardive dyskinesia 15.15 10.10 20 386473 7259 50211372
Hallucination, visual 15.15 10.10 70 386423 16512 50202119
Catheter site pain 14.99 10.10 5 386488 3757 50214874
Injection site haematoma 14.83 10.10 88 386405 5972 50212659
Sleep apnoea syndrome 14.78 10.10 114 386379 23754 50194877
Gastrointestinal disorder 14.76 10.10 872 385621 93584 50125047
Renal injury 14.73 10.10 27 386466 8584 50210047
Cardiomyopathy 14.71 10.10 65 386428 15521 50203110
Human antichimeric antibody positive 14.61 10.10 34 386459 1455 50217176
Infusion site pain 14.57 10.10 47 386446 12299 50206332
Colitis microscopic 14.53 10.10 17 386476 6503 50212128
Neonatal respiratory distress syndrome 14.52 10.10 49 386444 2605 50216026
Myoclonus 14.49 10.10 59 386434 14411 50204220
Coronary artery disease 14.46 10.10 151 386342 29575 50189056
Leukocytosis 14.39 10.10 107 386386 22472 50196159
Polyuria 14.38 10.10 20 386473 7101 50211530
Generalised oedema 14.38 10.10 55 386438 13676 50204955
Serum ferritin increased 14.35 10.10 78 386415 5124 50213507
Mouth ulceration 14.34 10.10 297 386196 27727 50190904
Hot flush 14.31 10.10 244 386249 43925 50174706
Starvation ketoacidosis 14.29 10.10 8 386485 61 50218570
Myelosuppression 14.25 10.10 54 386439 13463 50205168
Dysuria 14.19 10.10 144 386349 28360 50190271
Bundle branch block left 14.15 10.10 16 386477 6214 50212417
Ketoacidosis 14.14 10.10 6 386487 3889 50214742
Vascular device infection 14.03 10.10 8 386485 4376 50214255
HIV-associated neurocognitive disorder 14.02 10.10 10 386483 121 50218510
Urinary retention 14.01 10.10 130 386363 26060 50192571
Angina pectoris 14.01 10.10 130 386363 26058 50192573
Hallucination, auditory 13.99 10.10 39 386454 10689 50207942
Right ventricular failure 13.98 10.10 68 386425 15825 50202806
Immunodeficiency 13.98 10.10 174 386319 14654 50203977
Foetal distress syndrome 13.98 10.10 30 386463 1215 50217416
Joint lock 13.94 10.10 41 386452 2024 50216607
Speech disorder developmental 13.93 10.10 20 386473 585 50218046
Inflammatory marker increased 13.91 10.10 82 386411 5552 50213079
Clostridium difficile colitis 13.88 10.10 79 386414 17663 50200968
Hallucinations, mixed 13.85 10.10 7 386486 4096 50214535
Antibody test positive 13.84 10.10 44 386449 2267 50216364
Malaise 13.71 10.10 2303 384190 333229 49885402
Hypomagnesaemia 13.69 10.10 112 386381 23044 50195587
Personality disorder 13.68 10.10 8 386485 4316 50214315
Product substitution issue 13.65 10.10 58 386435 13999 50204632
Bone disorder 13.60 10.10 210 386283 18542 50200089
Multiple sclerosis 13.59 10.10 96 386397 20397 50198234
Lip swelling 13.58 10.10 122 386371 24614 50194017
Maternal exposure during breast feeding 13.55 10.10 55 386438 3199 50215432
Skin exfoliation 13.54 10.10 178 386315 33434 50185197
Surgery 13.51 10.10 314 386179 29891 50188740
Subdural haematoma 13.47 10.10 52 386441 12895 50205736
Foot fracture 13.44 10.10 222 386271 19869 50198762
Immunosuppression 13.43 10.10 100 386393 7326 50211305
Foetal alcohol syndrome 13.38 10.10 5 386488 12 50218619
Jaundice 13.37 10.10 133 386360 26296 50192335
Pancytopenia 13.36 10.10 777 385716 83253 50135378
Cyanosis 13.34 10.10 65 386428 15119 50203512
Hepatic cytolysis 13.34 10.10 26 386467 8077 50210554
Squamous cell carcinoma 13.31 10.10 103 386390 7636 50210995
Crystal nephropathy 13.29 10.10 23 386470 792 50217839
Pericardial effusion 13.27 10.10 128 386365 25461 50193170
Tendonitis 13.26 10.10 190 386303 16515 50202116
Transplant dysfunction 13.03 10.10 10 386483 4674 50213957
Hypertelorism 13.01 10.10 16 386477 401 50218230
Pneumonia viral 13.01 10.10 20 386473 6814 50211817
Autism spectrum disorder 13.01 10.10 21 386472 682 50217949
Device breakage 12.98 10.10 34 386459 9513 50209118
Purpura 12.94 10.10 36 386457 9875 50208756
Bundle branch block right 12.81 10.10 10 386483 4635 50213996
Infusion site swelling 12.73 10.10 22 386471 7154 50211477
Confusional state 12.66 10.10 1235 385258 184693 50033938
Blood loss anaemia 12.65 10.10 27 386466 8112 50210519
Visual impairment 12.64 10.10 411 386082 67864 50150767
Induced labour 12.62 10.10 24 386469 890 50217741
Product preparation error 12.59 10.10 9 386484 4363 50214268
Aspiration 12.59 10.10 33 386460 9231 50209400
Cervical incompetence 12.56 10.10 19 386474 583 50218048
Systemic inflammatory response syndrome 12.55 10.10 12 386481 5037 50213594
Acute myocardial infarction 12.55 10.10 153 386340 29120 50189511
Body mass index decreased 12.54 10.10 15 386478 365 50218266
Wound infection 12.53 10.10 145 386348 12003 50206628
Pseudomonas infection 12.50 10.10 34 386459 9396 50209235
Haematoma 12.50 10.10 161 386332 30349 50188282
Sinus bradycardia 12.43 10.10 55 386438 13128 50205503
Bradypnoea 12.40 10.10 4 386489 3070 50215561
Graft versus host disease in gastrointestinal tract 12.37 10.10 3 386490 2778 50215853
Occult blood 12.33 10.10 28 386465 1179 50217452
Therapy change 12.33 10.10 13 386480 5212 50213419
Tumour marker increased 12.30 10.10 7 386486 3833 50214798
Pregnancy with contraceptive device 12.28 10.10 8 386485 4071 50214560
Alcoholic liver disease 12.21 10.10 9 386484 115 50218516
Multiple-drug resistance 12.20 10.10 5 386488 3309 50215322
Rash erythematous 12.13 10.10 190 386303 34662 50183969
Pulseless electrical activity 12.11 10.10 21 386472 6820 50211811
Respiratory acidosis 12.10 10.10 17 386476 6011 50212620
Visual acuity reduced 12.10 10.10 97 386396 20042 50198589
Catheter management 12.09 10.10 3 386490 2736 50215895
Sexual dysfunction 12.07 10.10 5 386488 3287 50215344
Cardiotoxicity 12.05 10.10 22 386471 7005 50211626
Malignant mediastinal neoplasm 12.05 10.10 18 386475 546 50218085
Lymphoedema 12.01 10.10 33 386460 9089 50209542
Lymphatic fistula 12.01 10.10 21 386472 729 50217902
Hyperthyroidism 11.97 10.10 50 386443 12125 50206506
Joint warmth 11.94 10.10 30 386463 1349 50217282
Muscle twitching 11.92 10.10 69 386424 15362 50203269
Klebsiella infection 11.92 10.10 23 386470 7171 50211460
Epstein-Barr virus infection 11.92 10.10 22 386471 6975 50211656
Chills 11.90 10.10 610 385883 96077 50122554
Urinary incontinence 11.88 10.10 148 386345 28060 50190571
Intervertebral disc degeneration 11.86 10.10 156 386337 13305 50205326
Injection site irritation 11.85 10.10 65 386428 4285 50214346
Tongue disorder 11.85 10.10 115 386378 9101 50209530
Myocarditis 11.83 10.10 27 386466 7920 50210711
Femoral hernia incarcerated 11.79 10.10 21 386472 740 50217891
Human anti-human antibody test 11.78 10.10 15 386478 390 50218241
Influenza 11.69 10.10 814 385679 88724 50129907
Ulcer 11.66 10.10 218 386275 19982 50198649
Tendon disorder 11.59 10.10 75 386418 5247 50213384
Ankylosing spondylitis 11.58 10.10 94 386399 7071 50211560
Abnormal dreams 11.56 10.10 35 386458 9342 50209289
Affect lability 11.52 10.10 33 386460 8965 50209666
Colitis 11.49 10.10 216 386277 38313 50180318
Anger 11.48 10.10 46 386447 11287 50207344
Hypophagia 11.48 10.10 146 386347 27582 50191049
Infusion site pruritus 11.48 10.10 8 386485 3929 50214702
Arthritis bacterial 11.46 10.10 78 386415 5551 50213080
Pulmonary haemorrhage 11.43 10.10 20 386473 6472 50212159
Swollen tongue 11.39 10.10 152 386341 28478 50190153
Wound infection pseudomonas 11.34 10.10 28 386465 1245 50217386
Presyncope 11.33 10.10 124 386369 24074 50194557
Product complaint 11.33 10.10 47 386446 11419 50207212
Renal disorder 11.32 10.10 145 386348 27360 50191271
Foetal growth restriction 11.29 10.10 88 386405 6539 50212092
Delusion 11.28 10.10 42 386451 10527 50208104
Hereditary angioedema 11.28 10.10 15 386478 5427 50213204
Amylase increased 11.22 10.10 15 386478 5415 50213216
Drug screen positive 11.19 10.10 6 386487 3396 50215235
Abortion missed 11.18 10.10 32 386461 1556 50217075
Pancreatic steatosis 11.15 10.10 23 386470 906 50217725
Abortion threatened 11.13 10.10 17 386476 526 50218105
Endodontic procedure 11.10 10.10 46 386447 2700 50215931
Hepatitis acute 11.09 10.10 28 386465 7933 50210698
Carpal tunnel syndrome 11.06 10.10 186 386307 16707 50201924
Abortion incomplete 11.06 10.10 5 386488 3121 50215510
Polydipsia 11.05 10.10 5 386488 3119 50215512
Food allergy 11.04 10.10 29 386464 8108 50210523
Patent ductus arteriosus 11.03 10.10 58 386435 3762 50214869
Anterior chamber cleavage syndrome 11.03 10.10 10 386483 174 50218457
Ingrown hair 11.01 10.10 16 386477 473 50218158
Abdominal pain upper 11.01 10.10 1057 385436 158252 50060379
Myofascial pain syndrome 11.00 10.10 38 386455 2045 50216586
Trigeminal neuralgia 10.99 10.10 5 386488 3110 50215521
Embedded device 10.91 10.10 4 386489 2833 50215798
Drug-induced liver injury 10.88 10.10 150 386343 27945 50190686
Adverse event 10.87 10.10 423 386070 43340 50175291
Acute coronary syndrome 10.85 10.10 36 386457 9338 50209293
Lung transplant 10.84 10.10 4 386489 2821 50215810
Dermatitis exfoliative 10.83 10.10 14 386479 5128 50213503
Ileus paralytic 10.82 10.10 9 386484 4041 50214590
Chondropathy 10.82 10.10 38 386455 2062 50216569
Knee operation 10.82 10.10 69 386424 4804 50213827
Learning disorder 10.82 10.10 18 386475 600 50218031
Eating disorder 10.81 10.10 71 386422 15338 50203293
Product prescribing error 10.81 10.10 105 386388 20856 50197775
Bone density abnormal 10.77 10.10 49 386444 2996 50215635
Ear infection 10.72 10.10 267 386226 25703 50192928
Pulmonary alveolar haemorrhage 10.70 10.10 9 386484 4018 50214613
Exostosis 10.67 10.10 136 386357 11517 50207114
Hyperuricaemia 10.65 10.10 12 386481 4668 50213963
Forceps delivery 10.62 10.10 10 386483 183 50218448
Mental disorder 10.58 10.10 112 386381 21879 50196752
Rheumatoid lung 10.53 10.10 42 386451 2423 50216208
Head injury 10.50 10.10 125 386368 23895 50194736
Pathogen resistance 10.50 10.10 17 386476 5672 50212959
Incorrect product administration duration 10.47 10.10 36 386457 9239 50209392
Haemoglobin decreased 10.40 10.10 1117 385376 126099 50092532
Device issue 10.32 10.10 100 386393 19872 50198759
Bradykinesia 10.25 10.10 9 386484 3934 50214697
Paraesthesia 10.21 10.10 785 385708 119458 50099173
Placental insufficiency 10.19 10.10 27 386466 1254 50217377
Nail injury 10.19 10.10 15 386478 449 50218182
Cardiac disorder 10.18 10.10 250 386243 42729 50175902
Eosinophil count increased 10.16 10.10 34 386459 8796 50209835
Ankyloglossia congenital 10.15 10.10 10 386483 194 50218437
Vacuum extractor delivery 10.14 10.10 9 386484 152 50218479
Renal mass 10.13 10.10 35 386458 1883 50216748
Peripheral sensory neuropathy 10.13 10.10 22 386471 6569 50212062
Embolism 10.11 10.10 24 386469 6944 50211687
Stress at work 10.10 10.10 24 386469 1041 50217590

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 475.81 10.00 693 148704 31459 29393671
Drug abuse 296.03 10.00 30 149367 79853 29345277
Foetal exposure during pregnancy 267.36 10.00 553 148844 33314 29391816
Completed suicide 230.27 10.00 84 149313 90162 29334968
Toxicity to various agents 205.67 10.00 351 149046 173310 29251820
Arthralgia 198.38 10.00 1295 148102 138322 29286808
Psoriatic arthropathy 140.30 10.00 260 149137 14431 29410699
Dysmorphism 122.16 10.00 109 149288 2862 29422268
Sickle cell anaemia with crisis 100.00 10.00 92 149305 2516 29422614
Joint swelling 95.39 10.00 499 148898 49131 29375999
Drug interaction 91.86 10.00 602 148795 196783 29228347
Premature baby 88.09 10.00 238 149159 17042 29408088
Psoriasis 83.91 10.00 354 149043 31873 29393257
Enthesopathy 80.54 10.00 97 149300 3646 29421484
Death 76.65 10.00 1242 148155 340842 29084288
Exposure during pregnancy 76.23 10.00 147 149250 8407 29416723
Speech disorder developmental 72.59 10.00 67 149330 1840 29423290
Neonatal respiratory distress syndrome 66.55 10.00 89 149308 3721 29421409
Intentional overdose 66.47 10.00 58 149339 38470 29386660
Tenosynovitis 66.43 10.00 88 149309 3645 29421485
Musculoskeletal stiffness 62.81 10.00 363 149034 37095 29388035
Blood pressure fluctuation 61.82 10.00 231 149166 19663 29405467
Foetal anticonvulsant syndrome 60.78 10.00 49 149348 1115 29424015
Hypospadias 60.07 10.00 75 149322 2927 29422203
Atrial septal defect 58.46 10.00 115 149282 6674 29418456
Maternal exposure during pregnancy 53.98 10.00 84 149313 4039 29421091
Hepatic function abnormal 53.42 10.00 72 149325 39187 29385943
Autism spectrum disorder 52.71 10.00 58 149339 1974 29423156
Acute kidney injury 52.57 10.00 984 148413 264283 29160847
Maternal drugs affecting foetus 51.93 10.00 80 149317 3813 29421317
Drug resistance 51.67 10.00 22 149375 21518 29403612
Lower respiratory tract infection 49.88 10.00 265 149132 26237 29398893
Synovitis 49.61 10.00 144 149253 10746 29414384
Pain 48.34 10.00 1170 148227 170262 29254868
Nasopharyngitis 48.19 10.00 487 148910 59178 29365952
Product use in unapproved indication 47.74 10.00 251 149146 86624 29338506
Low birth weight baby 47.59 10.00 104 149293 6504 29418626
Learning disorder 47.06 10.00 40 149357 982 29424148
Small for dates baby 46.97 10.00 73 149324 3506 29421624
Cryptorchism 46.22 10.00 53 149344 1889 29423241
Hypoglycaemia neonatal 46.10 10.00 50 149347 1674 29423456
C-reactive protein abnormal 44.96 10.00 101 149296 6435 29418695
Febrile neutropenia 44.06 10.00 359 149038 111881 29313249
Overdose 41.98 10.00 234 149163 79585 29345545
Tongue disorder 41.71 10.00 80 149317 4556 29420574
Maternal exposure during breast feeding 41.32 10.00 44 149353 1442 29423688
Ventricular septal defect 40.87 10.00 68 149329 3461 29421669
Sopor 40.74 10.00 4 149393 10930 29414200
Arthritis 40.34 10.00 240 149157 24779 29400351
Suicide attempt 40.20 10.00 69 149328 34041 29391089
Intentional product misuse 40.04 10.00 71 149326 34590 29390540
Drug dependence 39.42 10.00 29 149368 20952 29404178
Drug reaction with eosinophilia and systemic symptoms 37.41 10.00 52 149345 27940 29397190
Rhabdomyolysis 37.26 10.00 169 149228 60639 29364491
Syndactyly 37.06 10.00 31 149366 744 29424386
Foot deformity 37.00 10.00 70 149327 3945 29421185
Haemoglobin decreased 36.59 10.00 759 148638 107616 29317514
Blood pressure systolic increased 36.30 10.00 175 149222 16670 29408460
Coma 35.44 10.00 93 149304 39357 29385773
Rheumatoid nodule 34.68 10.00 48 149349 2074 29423056
Basal cell carcinoma 34.53 10.00 173 149224 16737 29408393
Developmental delay 33.95 10.00 52 149345 2466 29422664
Cardiac failure 33.72 10.00 248 149149 79039 29346091
Exposure via breast milk 33.03 10.00 42 149355 1670 29423460
Joint laxity 32.75 10.00 22 149375 374 29424756
Osteoarthritis 32.02 10.00 178 149219 17925 29407205
Arthropathy 31.75 10.00 202 149195 21352 29403778
Alanine aminotransferase abnormal 31.63 10.00 55 149342 2902 29422228
Pulmonary fibrosis 31.53 10.00 159 149238 15423 29409707
Congenital hand malformation 31.49 10.00 25 149372 556 29424574
Tendonitis 31.32 10.00 100 149297 7861 29417269
Drug intolerance 30.87 10.00 377 149020 48002 29377128
Respiratory arrest 30.67 10.00 52 149345 25781 29399349
Cytomegalovirus infection 30.16 10.00 44 149353 23171 29401959
Talipes 29.99 10.00 41 149356 1751 29423379
Drug withdrawal syndrome 29.91 10.00 28 149369 17956 29407174
Hypermobility syndrome 29.88 10.00 20 149377 338 29424792
Blood pressure systolic abnormal 29.66 10.00 45 149352 2116 29423014
Jaundice neonatal 29.42 10.00 34 149363 1222 29423908
Off label use 29.17 10.00 1233 148164 299567 29125563
Intellectual disability 28.71 10.00 32 149365 1105 29424025
Serum ferritin increased 28.51 10.00 77 149320 5511 29419619
Renal failure 28.29 10.00 425 148972 118174 29306956
Palmar-plantar erythrodysaesthesia syndrome 28.25 10.00 20 149377 14739 29410391
Disease progression 28.17 10.00 271 149126 81645 29343485
Language disorder 27.18 10.00 41 149356 1918 29423212
Foetal growth restriction 26.81 10.00 59 149338 3707 29421423
Large for dates baby 25.98 10.00 27 149370 860 29424270
Poisoning 25.97 10.00 9 149388 9984 29415146
Plagiocephaly 25.93 10.00 21 149376 481 29424649
Infusion related reaction 25.87 10.00 337 149060 43549 29381581
Joint effusion 25.86 10.00 62 149335 4122 29421008
Pancytopenia 25.65 10.00 575 148822 82593 29342537
Hyperbilirubinaemia neonatal 24.31 10.00 24 149373 718 29424412
Urticaria 24.19 10.00 169 149228 54491 29370639
Peripheral swelling 24.04 10.00 454 148943 63285 29361845
Pain in extremity 24.02 10.00 729 148668 109704 29315426
Renal impairment 23.93 10.00 279 149118 81054 29344076
Knee deformity 23.90 10.00 21 149376 540 29424590
Polyarthritis 23.90 10.00 58 149339 3887 29421243
Body temperature decreased 23.86 10.00 112 149285 10552 29414578
Astigmatism 23.84 10.00 27 149370 949 29424181
Pathogen resistance 23.47 10.00 6 149391 8110 29417020
Selective eating disorder 23.35 10.00 35 149362 1628 29423502
Multiple organ dysfunction syndrome 23.34 10.00 205 149192 62911 29362219
Dysgraphia 23.24 10.00 39 149358 1999 29423131
Motor developmental delay 22.85 10.00 22 149375 638 29424492
Behaviour disorder 22.80 10.00 54 149343 3562 29421568
Blood pressure increased 22.36 10.00 509 148888 73294 29351836
Caesarean section 22.20 10.00 37 149360 1886 29423244
Suicidal ideation 22.15 10.00 95 149302 34621 29390509
Neck mass 21.99 10.00 32 149365 1449 29423681
Hand deformity 21.99 10.00 39 149358 2091 29423039
Hyperglycaemia 21.77 10.00 94 149303 34193 29390937
Pyrexia 21.75 10.00 1210 148187 286412 29138718
Substance abuse 21.69 10.00 4 149393 6783 29418347
Hypoglycaemia 21.63 10.00 149 149248 48197 29376933
Encephalitis toxic 21.50 10.00 15 149382 272 29424858
Otitis media 21.26 10.00 43 149354 2546 29422584
Skin cancer 21.24 10.00 92 149305 8376 29416754
Knee arthroplasty 21.08 10.00 71 149326 5738 29419392
Constipation 20.84 10.00 429 148968 113731 29311399
Vitamin B12 deficiency 20.79 10.00 49 149348 3222 29421908
Drug withdrawal syndrome neonatal 20.66 10.00 50 149347 3345 29421785
Somnolence 20.60 10.00 342 149055 93613 29331517
C-reactive protein increased 20.55 10.00 326 149071 43937 29381193
Blood pressure diastolic decreased 20.54 10.00 80 149317 6942 29418188
Hypotonia neonatal 20.21 10.00 28 149369 1211 29423919
Strabismus 20.17 10.00 30 149367 1386 29423744
Musculoskeletal pain 19.95 10.00 229 149168 28724 29396406
Rash maculo-papular 19.79 10.00 60 149337 24229 29400901
Cleft lip 19.79 10.00 15 149382 311 29424819
Medical device implantation 19.59 10.00 19 149378 556 29424574
Dyslexia 19.54 10.00 15 149382 317 29424813
Blood pressure diastolic abnormal 19.34 10.00 41 149356 2510 29422620
Hydrocele 19.19 10.00 35 149362 1918 29423212
Decreased gait velocity 19.19 10.00 11 149386 139 29424991
Poisoning deliberate 19.15 10.00 3 149394 5728 29419402
No adverse event 19.12 10.00 37 149360 17441 29407689
Dyspraxia 19.09 10.00 16 149381 385 29424745
Colitis ulcerative 19.01 10.00 120 149277 12649 29412481
Heart rate decreased 18.98 10.00 201 149196 24711 29400419
Agitation neonatal 18.95 10.00 25 149372 1031 29424099
Arthritis bacterial 18.81 10.00 57 149340 4356 29420774
Mobility decreased 18.72 10.00 206 149191 25574 29399556
Aptyalism 18.60 10.00 14 149383 287 29424843
Altered state of consciousness 18.54 10.00 46 149351 19843 29405287
Attention deficit hyperactivity disorder 18.42 10.00 37 149360 2180 29422950
Loss of personal independence in daily activities 18.34 10.00 203 149194 25237 29399893
Acute hepatic failure 18.28 10.00 20 149377 11932 29413198
Bradycardia 18.21 10.00 228 149169 65401 29359729
Shock 18.07 10.00 52 149345 21352 29403778
Foetal disorder 18.02 10.00 21 149376 762 29424368
Crohn's disease 17.97 10.00 44 149353 2965 29422165
Vitamin D deficiency 17.84 10.00 65 149332 5464 29419666
Lacrimal disorder 17.73 10.00 14 149383 309 29424821
Anal fistula 17.71 10.00 54 149343 4141 29420989
Juvenile idiopathic arthritis 17.69 10.00 28 149369 1366 29423764
Congenital bladder anomaly 17.55 10.00 13 149384 260 29424870
Limb reduction defect 17.50 10.00 13 149384 261 29424869
Malignant melanoma 17.35 10.00 77 149320 7084 29418046
Weight decrease neonatal 17.35 10.00 14 149383 319 29424811
Congenital anomaly 17.31 10.00 27 149370 1301 29423829
Renal aplasia 17.26 10.00 19 149378 647 29424483
Psychomotor retardation 17.23 10.00 43 149354 2933 29422197
Tuberculosis 17.15 10.00 77 149320 7119 29418011
Mastication disorder 17.13 10.00 25 149372 1135 29423995
Wound 17.12 10.00 112 149285 11951 29413179
Congenital foot malformation 17.06 10.00 15 149382 386 29424744
Blood pressure diastolic increased 17.04 10.00 49 149348 3637 29421493
Depressed level of consciousness 16.95 10.00 113 149284 36829 29388301
Patent ductus arteriosus 16.84 10.00 44 149353 3087 29422043
Venoocclusive liver disease 16.69 10.00 7 149390 6910 29418220
Ankyloglossia congenital 16.57 10.00 13 149384 284 29424846
Respiratory rate increased 16.33 10.00 87 149310 8621 29416509
Sarcopenia 16.33 10.00 14 149383 348 29424782
Grip strength decreased 16.26 10.00 36 149361 2271 29422859
Bronchiolitis 16.15 10.00 40 149357 2715 29422415
Malignant neoplasm progression 16.14 10.00 269 149128 73590 29351540
Haemangioma congenital 16.09 10.00 16 149381 483 29424647
Joint stiffness 16.00 10.00 92 149305 9381 29415749
Post procedural infection 15.96 10.00 53 149344 4252 29420878
Back disorder 15.84 10.00 66 149331 5907 29419223
Inflammation 15.77 10.00 180 149217 22548 29402582
Diaphragmatic disorder 15.73 10.00 22 149375 960 29424170
Umbilical hernia 15.69 10.00 48 149349 3687 29421443
Cerebral haemorrhage neonatal 15.62 10.00 12 149385 254 29424876
Nasal disorder 15.56 10.00 27 149370 1422 29423708
Failure to anastomose 15.56 10.00 11 149386 204 29424926
Infective pulmonary exacerbation of cystic fibrosis 15.55 10.00 6 149391 6230 29418900
Haematocrit decreased 15.51 10.00 219 149178 28803 29396327
Injection site pain 15.45 10.00 240 149157 32206 29392924
Multiple congenital abnormalities 15.43 10.00 16 149381 508 29424622
Microcephaly 15.43 10.00 19 149378 731 29424399
Joint range of motion decreased 15.36 10.00 66 149331 5988 29419142
Arthrodesis 15.35 10.00 15 149382 443 29424687
Scoliosis 15.22 10.00 35 149362 2265 29422865
Cardiac arrest 15.21 10.00 323 149074 85268 29339862
Pectus excavatum 15.19 10.00 11 149386 212 29424918
Emphysema 15.16 10.00 85 149312 8586 29416544
Lung neoplasm malignant 15.04 10.00 124 149273 14233 29410897
Bradycardia neonatal 14.97 10.00 21 149376 919 29424211
Angioedema 14.95 10.00 97 149300 31818 29393312
Aspergillus infection 14.80 10.00 19 149378 10562 29414568
Osteonecrosis of jaw 14.76 10.00 39 149358 16471 29408659
Septic arthritis staphylococcal 14.68 10.00 15 149382 468 29424662
Product quality issue 14.63 10.00 37 149360 15858 29409272
Polydactyly 14.61 10.00 23 149374 1117 29424013
Respiratory disorder neonatal 14.59 10.00 26 149371 1399 29423731
Oesophageal fibrosis 14.59 10.00 10 149387 176 29424954
Hypertelorism 14.58 10.00 16 149381 543 29424587
Chronic obstructive pulmonary disease 14.51 10.00 289 149108 40666 29384464
Proteinuria 14.39 10.00 37 149360 15767 29409363
Second primary malignancy 14.33 10.00 8 149389 6697 29418433
Weight decreased 14.26 10.00 914 148483 149991 29275139
Neurotoxicity 14.26 10.00 33 149364 14580 29410550
C-reactive protein decreased 14.24 10.00 27 149370 1524 29423606
Kidney infection 14.23 10.00 54 149343 4629 29420501
Decreased appetite 14.18 10.00 595 148802 144747 29280383
Spinal disorder 14.16 10.00 46 149351 3649 29421481
Psychotic disorder 14.05 10.00 54 149343 20300 29404830
Ear disorder 14.03 10.00 24 149373 1250 29423880
Progressive multifocal leukoencephalopathy 14.00 10.00 14 149383 8705 29416425
Wrong technique in product usage process 13.98 10.00 97 149300 31331 29393799
Maternal exposure timing unspecified 13.96 10.00 13 149384 361 29424769
Cellulitis 13.83 10.00 316 149081 45524 29379606
Neutropenia 13.75 10.00 535 148862 131176 29293954
Haemangioma 13.75 10.00 28 149369 1666 29423464
Arnold-Chiari malformation 13.67 10.00 12 149385 308 29424822
Hernia pain 13.47 10.00 11 149386 255 29424875
Immunodeficiency 13.33 10.00 51 149346 4389 29420741
Finger deformity 13.25 10.00 22 149375 1118 29424012
Hypertriglyceridaemia 13.20 10.00 11 149386 7464 29417666
Disseminated intravascular coagulation 13.16 10.00 54 149343 19926 29405204
Vascular insufficiency 12.87 10.00 12 149385 334 29424796
Alcoholic liver disease 12.85 10.00 15 149382 545 29424585
Contraindicated product administered 12.82 10.00 145 149252 18121 29407009
Foetal heart rate deceleration abnormality 12.76 10.00 14 149383 475 29424655
Tooth malformation 12.72 10.00 9 149388 167 29424963
Anal atresia 12.71 10.00 11 149386 277 29424853
Poor venous access 12.70 10.00 40 149357 3121 29422009
Lipase increased 12.70 10.00 14 149383 8323 29416807
Inguinal hernia 12.66 10.00 67 149330 6621 29418509
Lactic acidosis 12.66 10.00 95 149302 30152 29394978
Peripheral artery thrombosis 12.64 10.00 31 149366 2091 29423039
Spina bifida 12.63 10.00 12 149385 342 29424788
Radiation inflammation 12.61 10.00 10 149387 222 29424908
Ear infection 12.61 10.00 77 149320 8023 29417107
Foetal distress syndrome 12.59 10.00 20 149377 979 29424151
Incorrect route of product administration 12.58 10.00 22 149375 10779 29414351
Status epilepticus 12.56 10.00 22 149375 10772 29414358
Ankylosing spondylitis 12.56 10.00 48 149349 4128 29421002
Blood parathyroid hormone decreased 12.52 10.00 18 149379 806 29424324
Blood insulin increased 12.49 10.00 12 149385 347 29424783
Fall 12.47 10.00 1048 148349 176130 29249000
Injection site bruising 12.40 10.00 73 149324 7507 29417623
Sexual dysfunction 12.33 10.00 7 149390 5807 29419323
Developmental coordination disorder 12.32 10.00 9 149388 176 29424954
Red blood cell sedimentation rate increased 12.30 10.00 72 149325 7389 29417741
Coma scale abnormal 12.24 10.00 42 149355 3427 29421703
Diverticular perforation 12.21 10.00 38 149359 2946 29422184
Obsessive-compulsive disorder 12.10 10.00 4 149393 4572 29420558
Ear malformation 12.04 10.00 11 149386 298 29424832
Haemolysis 12.04 10.00 68 149329 6888 29418242
Erythrosis 12.03 10.00 6 149391 56 29425074
Pleural fibrosis 11.96 10.00 23 149374 1312 29423818
Palindromic rheumatism 11.90 10.00 9 149388 186 29424944
Infection 11.78 10.00 487 148910 76264 29348866
Cholelithiasis 11.68 10.00 145 149252 18527 29406603
Gangrene neonatal 11.65 10.00 9 149388 192 29424938
Congenital hydronephrosis 11.64 10.00 16 149381 687 29424443
Chronic graft versus host disease 11.61 10.00 3 149394 4026 29421104
Arthritis infective 11.59 10.00 36 149361 2788 29422342
Suspected suicide 11.57 10.00 3 149394 4017 29421113
Bloody discharge 11.55 10.00 12 149385 382 29424748
Cystitis haemorrhagic 11.52 10.00 5 149392 4837 29420293
Sedation 11.49 10.00 47 149350 17358 29407772
Communication disorder 11.48 10.00 32 149365 2333 29422797
Excessive cerumen production 11.35 10.00 10 149387 258 29424872
Red blood cell sedimentation rate 11.34 10.00 14 149383 540 29424590
Neonatal seizure 11.17 10.00 13 149384 471 29424659
Mouth ulceration 11.15 10.00 90 149307 10265 29414865
Pulmonary artery stenosis congenital 11.12 10.00 13 149384 473 29424657
Regurgitation 11.08 10.00 22 149375 1285 29423845
Neonatal infection 11.08 10.00 12 149385 401 29424729
Meningeal disorder 11.06 10.00 11 149386 332 29424798
Acute graft versus host disease 11.00 10.00 8 149389 5816 29419314
Oxygen saturation decreased 10.95 10.00 301 149096 44636 29380494
Pulmonary tuberculosis 10.91 10.00 47 149350 4268 29420862
Blood magnesium decreased 10.88 10.00 55 149342 5339 29419791
Joint injury 10.85 10.00 66 149331 6867 29418263
Brain oedema 10.83 10.00 29 149368 12191 29412939
Cerebral haemorrhage 10.77 10.00 104 149293 31322 29393808
Cleft palate 10.75 10.00 14 149383 570 29424560
Injection site rash 10.75 10.00 41 149356 3523 29421607
Prostate cancer 10.73 10.00 185 149212 25342 29399788
Anaemia vitamin B12 deficiency 10.73 10.00 10 149387 278 29424852
Nephropathy toxic 10.73 10.00 24 149373 10732 29414398
Nail bed inflammation 10.71 10.00 8 149389 162 29424968
Dermatitis psoriasiform 10.69 10.00 20 149377 1118 29424012
Skin lesion 10.68 10.00 142 149255 18430 29406700
Lower respiratory tract congestion 10.68 10.00 19 149378 1021 29424109
Cirrhosis alcoholic 10.63 10.00 16 149381 747 29424383
Withdrawal syndrome 10.58 10.00 25 149372 10967 29414163
Dysgeusia 10.58 10.00 69 149328 22605 29402525
Irritability 10.54 10.00 67 149330 22085 29403045
Anti-erythropoietin antibody positive 10.54 10.00 17 149380 843 29424287
Vomiting 10.53 10.00 926 148471 211334 29213796
Low set ears 10.52 10.00 12 149385 425 29424705
End stage renal disease 10.48 10.00 14 149383 7650 29417480
Oedema 10.36 10.00 143 149254 40340 29384790
Appendix disorder 10.35 10.00 14 149383 592 29424538
Steatorrhoea 10.31 10.00 15 149382 679 29424451
Educational problem 10.28 10.00 13 149384 514 29424616
Injection site swelling 10.22 10.00 82 149315 9335 29415795
Agitation 10.20 10.00 190 149207 51114 29374016
Foetal hypokinesia 10.17 10.00 11 149386 367 29424763
Therapeutic product effect decreased 10.16 10.00 207 149190 29244 29395886
Non-Hodgkin's lymphoma 10.15 10.00 23 149374 1474 29423656
Acute generalised exanthematous pustulosis 10.12 10.00 8 149389 5575 29419555
Spinal pain 10.10 10.00 50 149347 4814 29420316
Hyperbilirubinaemia 10.07 10.00 40 149357 14894 29410236
Pancreatic duct stenosis 10.04 10.00 8 149389 179 29424951
Aggression 10.03 10.00 123 149274 35418 29389712
Lung cancer metastatic 10.02 10.00 31 149366 2396 29422734
Therapy partial responder 10.01 10.00 7 149390 5192 29419938

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1205.20 9.87 2964 401048 161330 63933390
Completed suicide 906.49 9.87 157 403855 224257 63870463
Pemphigus 780.39 9.87 1380 402632 59321 64035399
Arthropathy 760.13 9.87 2060 401952 118907 63975813
Systemic lupus erythematosus 744.08 9.87 1558 402454 76054 64018666
Joint swelling 741.17 9.87 2989 401023 212393 63882327
Hand deformity 714.59 9.87 1354 402658 61417 64033303
Toxicity to various agents 691.44 9.87 755 403257 362758 63731962
Synovitis 685.18 9.87 1749 402263 97341 63997379
Glossodynia 647.43 9.87 1322 402690 63374 64031346
Arthralgia 631.70 9.87 4832 399180 437428 63657292
Drug abuse 612.34 9.87 60 403952 132314 63962406
Maternal exposure during pregnancy 599.31 9.87 1630 402382 94254 64000466
Infusion related reaction 556.26 9.87 2271 401741 162196 63932524
Anti-cyclic citrullinated peptide antibody positive 536.92 9.87 1047 402965 48515 64046205
Wound 523.50 9.87 1345 402667 75132 64019588
Pericarditis 501.86 9.87 1169 402843 61347 64033373
Pain 445.31 9.87 5357 398655 548154 63546566
Abdominal discomfort 422.73 9.87 2255 401757 180067 63914653
Alopecia 405.94 9.87 2081 401931 163609 63931111
Swelling 381.88 9.87 1997 402015 158221 63936499
Therapeutic product effect decreased 370.28 9.87 1568 402444 113783 63980937
Contraindicated product administered 365.91 9.87 1491 402521 106338 63988382
Discomfort 356.82 9.87 1217 402795 79661 64015059
Nasopharyngitis 353.25 9.87 2269 401743 193804 63900916
Death 350.96 9.87 1693 402319 481012 63613708
Drug interaction 343.36 9.87 1143 402869 360940 63733780
Rheumatoid factor positive 320.31 9.87 689 403323 34249 64060471
Exposure during pregnancy 313.48 9.87 1135 402877 76540 64018180
Duodenal ulcer perforation 311.92 9.87 678 403334 33947 64060773
Helicobacter infection 309.60 9.87 719 403293 37643 64057077
Drug intolerance 305.16 9.87 2120 401892 185872 63908848
Musculoskeletal stiffness 295.05 9.87 1538 402474 121668 63973052
Intentional overdose 277.26 9.87 108 403904 89836 64004884
Hepatic enzyme increased 268.84 9.87 1559 402453 128384 63966336
Psoriatic arthropathy 232.49 9.87 697 403315 42584 64052136
Febrile neutropenia 225.41 9.87 528 403484 187129 63907591
C-reactive protein abnormal 224.13 9.87 535 403477 28512 64066208
Lower respiratory tract infection 202.08 9.87 1145 402867 93469 64001251
Sinusitis 202.06 9.87 1585 402427 144343 63950377
Impaired healing 200.12 9.87 830 403182 59643 64035077
Acute kidney injury 192.19 9.87 1843 402169 447397 63647323
Overdose 188.38 9.87 453 403559 159113 63935607
Red blood cell sedimentation rate abnormal 183.28 9.87 350 403662 15956 64078764
Product use issue 176.10 9.87 1584 402428 150131 63944589
Hypersensitivity 173.86 9.87 1939 402073 194513 63900207
Peripheral swelling 173.28 9.87 2038 401974 207115 63887605
Treatment failure 171.27 9.87 1286 402726 115530 63979190
Muscle injury 168.57 9.87 453 403559 25984 64068736
Blood pressure fluctuation 166.99 9.87 706 403306 51165 64043555
Sickle cell anaemia with crisis 163.41 9.87 184 403828 5148 64089572
Arthritis 155.68 9.87 978 403034 82836 64011884
Depressed level of consciousness 155.66 9.87 168 403844 81268 64013452
Folliculitis 153.69 9.87 476 403536 29601 64065119
Cardiac arrest 153.63 9.87 475 403537 153589 63941131
Hip arthroplasty 151.69 9.87 381 403631 20970 64073750
Sleep disorder due to general medical condition, insomnia type 145.76 9.87 428 403584 25842 64068878
Irritable bowel syndrome 145.59 9.87 540 403472 36829 64057891
Knee arthroplasty 145.17 9.87 435 403577 26564 64068156
Psoriasis 143.48 9.87 853 403159 70850 64023870
Suicide attempt 141.91 9.87 141 403871 70866 64023854
Respiratory arrest 136.73 9.87 81 403931 52904 64041816
Drug ineffective 135.32 9.87 6492 397520 833755 63260965
Osteoarthritis 132.90 9.87 763 403249 62573 64032147
Pregnancy 130.49 9.87 355 403657 20510 64074210
Weight increased 128.27 9.87 1962 402050 211386 63883334
Hepatic function abnormal 128.19 9.87 128 403884 64185 64030535
Cardiac failure 127.14 9.87 415 403597 131958 63962762
Blister 125.29 9.87 903 403109 80064 64014656
Rhabdomyolysis 121.73 9.87 244 403768 91482 64003238
Abortion spontaneous 120.29 9.87 389 403623 24754 64069966
Sopor 119.04 9.87 21 403991 29640 64065080
Injection site erythema 118.57 9.87 805 403207 69995 64024725
Malignant neoplasm progression 118.26 9.87 340 403672 112531 63982189
Renal failure 117.66 9.87 662 403350 181026 63913694
Drug reaction with eosinophilia and systemic symptoms 113.79 9.87 103 403909 54114 64040606
Bradycardia 111.20 9.87 374 403638 117845 63976875
Infection 109.49 9.87 1696 402316 183184 63911536
Disease progression 107.81 9.87 488 403524 141192 63953528
Neutropenia 105.67 9.87 975 403037 238649 63856071
Lactic acidosis 104.25 9.87 139 403873 61271 64033449
Drug resistance 103.53 9.87 45 403967 35057 64059663
Enthesopathy 98.76 9.87 199 403813 9439 64085281
Contusion 98.06 9.87 1119 402893 112846 63981874
Blood pressure systolic increased 96.80 9.87 585 403427 48868 64045852
Ill-defined disorder 96.57 9.87 537 403475 43515 64051205
Red blood cell sedimentation rate increased 95.04 9.87 418 403594 30817 64063903
Constipation 94.81 9.87 948 403064 228389 63866331
Intentional product misuse 93.63 9.87 195 403817 72100 64022620
Sedation 91.60 9.87 75 403937 41387 64053333
Hypoglycaemia 90.38 9.87 276 403736 89616 64005104
Injection site pruritus 90.30 9.87 472 403540 37354 64057366
Cytomegalovirus infection 90.29 9.87 61 403951 37138 64057582
Drug dependence 88.70 9.87 49 403963 33263 64061457
Joint effusion 88.04 9.87 233 403779 13240 64081480
Multiple organ dysfunction syndrome 87.93 9.87 332 403680 101081 63993639
Injection site pain 86.64 9.87 1073 402939 110335 63984385
Juvenile idiopathic arthritis 86.53 9.87 114 403898 3765 64090955
Product use in unapproved indication 84.30 9.87 704 403308 175914 63918806
Blood pressure diastolic abnormal 83.96 9.87 212 403800 11705 64083015
Live birth 83.88 9.87 204 403808 11000 64083720
Condition aggravated 83.72 9.87 2983 401029 369443 63725277
Injection site reaction 82.60 9.87 538 403474 46126 64048594
Renal impairment 82.03 9.87 502 403510 134515 63960205
Blood pressure systolic abnormal 82.01 9.87 188 403824 9754 64084966
Osteoporosis 81.22 9.87 496 403516 41584 64053136
Rheumatic fever 79.17 9.87 178 403834 9116 64085604
Cardio-respiratory arrest 79.04 9.87 332 403680 98061 63996659
Pain in extremity 78.90 9.87 2470 401542 300615 63794105
Disability assessment scale score increased 78.71 9.87 88 403924 2442 64092278
Hyperglycaemia 78.49 9.87 165 403847 60803 64033917
Fatigue 77.94 9.87 5565 398447 743165 63351555
Hypotension 76.97 9.87 1808 402204 379166 63715554
Rheumatoid nodule 76.87 9.87 213 403799 12438 64082282
Device expulsion 76.52 9.87 19 403993 21117 64073603
Respiratory failure 76.23 9.87 644 403368 160539 63934181
Injection site swelling 75.18 9.87 480 403532 40873 64053847
Poisoning 74.82 9.87 22 403990 21857 64072863
Somnolence 74.42 9.87 866 403146 202779 63891941
Grip strength decreased 73.83 9.87 200 403812 11524 64083196
Swollen joint count increased 73.18 9.87 154 403858 7535 64087185
Caesarean section 72.69 9.87 194 403818 11080 64083640
Tenosynovitis 72.67 9.87 200 403812 11633 64083087
Neoplasm progression 72.34 9.87 90 403922 40874 64053846
Blood pressure diastolic decreased 71.34 9.87 303 403709 21998 64072722
Poisoning deliberate 71.30 9.87 3 404009 13455 64081265
Rash 69.84 9.87 3526 400486 455023 63639697
Foot deformity 69.80 9.87 245 403767 16259 64078461
Disseminated intravascular coagulation 69.63 9.87 60 403952 32288 64062432
Fibromyalgia 69.49 9.87 422 403590 35309 64059411
Musculoskeletal pain 67.13 9.87 792 403220 80502 64014218
Joint laxity 66.09 9.87 77 403935 2237 64092483
Intentional self-injury 66.09 9.87 51 403961 28993 64065727
Agitation 65.05 9.87 308 403704 88059 64006661
Coma 63.54 9.87 307 403705 87308 64007412
Heart rate decreased 62.82 9.87 573 403439 54494 64040226
Palmar-plantar erythrodysaesthesia syndrome 62.59 9.87 53 403959 28766 64065954
Joint stiffness 61.63 9.87 363 403649 30041 64064679
Drug withdrawal syndrome 61.52 9.87 63 403949 31228 64063492
C-reactive protein increased 61.32 9.87 884 403128 94025 64000695
Hepatic failure 60.87 9.87 163 403849 55231 64039489
Gastrointestinal disorder 60.54 9.87 842 403170 88867 64005853
Cardiac failure congestive 60.27 9.87 525 403487 130055 63964665
Serotonin syndrome 58.79 9.87 97 403915 39185 64055535
Injection site bruising 58.77 9.87 410 403602 35963 64058757
Thrombocytopenia 58.32 9.87 1018 402994 222783 63871937
Altered state of consciousness 58.22 9.87 92 403920 37810 64056910
Tachycardia 58.21 9.87 627 403385 148952 63945768
Basal cell carcinoma 57.95 9.87 361 403651 30477 64064243
Localised infection 57.88 9.87 355 403657 29806 64064914
Blood pressure increased 57.05 9.87 1450 402562 171102 63923618
Inflammation 56.96 9.87 643 403369 64657 64030063
Shock 56.70 9.87 95 403917 38145 64056575
Anaemia 56.45 9.87 1875 402137 376805 63717915
Bone erosion 56.01 9.87 180 403832 11415 64083305
Syncope 55.78 9.87 675 403337 156960 63937760
Gestational diabetes 55.59 9.87 114 403898 5476 64089244
Hypoxia 55.50 9.87 324 403688 87825 64006895
Femur fracture 55.28 9.87 385 403627 33750 64060970
Cholestasis 54.82 9.87 125 403887 44747 64049973
Polyarthritis 54.57 9.87 159 403853 9556 64085164
Loss of personal independence in daily activities 52.56 9.87 689 403323 71765 64022955
Tongue disorder 52.54 9.87 181 403831 11899 64082821
Body temperature decreased 52.19 9.87 309 403703 25619 64069101
Immune reconstitution inflammatory syndrome 51.89 9.87 8 404004 12462 64082258
Injection site rash 51.22 9.87 215 403797 15527 64079193
Blood pressure diastolic increased 51.11 9.87 166 403846 10586 64084134
Cerebral haemorrhage 49.84 9.87 159 403853 50931 64043789
Oropharyngeal pain 49.81 9.87 808 403204 88059 64006661
Tendonitis 49.73 9.87 255 403757 20027 64074693
Mydriasis 47.81 9.87 18 403994 15294 64079426
Acute hepatic failure 47.55 9.87 56 403956 26056 64068664
Respiratory depression 47.46 9.87 46 403966 23397 64071323
Sedation complication 47.05 9.87 5 404007 10349 64084371
Premature delivery 46.48 9.87 235 403777 18354 64076366
Vomiting 45.70 9.87 2908 401104 548209 63546511
Hepatocellular injury 45.38 9.87 139 403873 45096 64049624
Brain oedema 45.06 9.87 43 403969 22032 64072688
Tenderness 45.00 9.87 242 403770 19360 64075360
Nodule 44.95 9.87 227 403785 17720 64077000
Neuropathy peripheral 44.77 9.87 495 403517 117030 63977690
Fracture 44.74 9.87 234 403778 18521 64076199
Joint injury 44.61 9.87 271 403741 22676 64072044
Neck mass 44.46 9.87 86 403926 3958 64090762
Synovial cyst 44.13 9.87 127 403885 7580 64087140
Pre-eclampsia 44.05 9.87 111 403901 6120 64088600
Stomatitis 43.57 9.87 945 403067 108660 63986060
Hyperhidrosis 43.39 9.87 537 403475 124383 63970337
Joint destruction 43.29 9.87 80 403932 3556 64091164
Maternal exposure before pregnancy 43.19 9.87 78 403934 3405 64091315
Myalgia 43.08 9.87 716 403296 157901 63936819
Tremor 42.97 9.87 661 403351 147569 63947151
Myocardial infarction 42.94 9.87 755 403257 165066 63929654
Leukopenia 42.83 9.87 416 403596 100826 63993894
Pulmonary fibrosis 42.66 9.87 327 403685 29551 64065169
Venoocclusive liver disease 42.65 9.87 6 404006 10009 64084711
Suspected suicide 42.53 9.87 3 404009 8651 64086069
Neck deformity 42.41 9.87 53 403959 1659 64093061
Electrocardiogram QT prolonged 42.40 9.87 307 403705 79141 64015579
Infective pulmonary exacerbation of cystic fibrosis 41.94 9.87 11 404001 11785 64082935
Orthostatic hypotension 41.81 9.87 151 403861 46587 64048133
Skin ulcer 41.57 9.87 440 403572 43534 64051186
Urticaria 41.33 9.87 661 403351 146656 63948064
Decreased appetite 41.12 9.87 1396 402616 279893 63814827
Dyspnoea 40.16 9.87 3917 400095 714757 63379963
Limb deformity 40.08 9.87 74 403938 3287 64091433
Herpes zoster 40.00 9.87 708 403304 78479 64016241
Alanine aminotransferase abnormal 39.92 9.87 114 403898 6774 64087946
Hyponatraemia 39.83 9.87 671 403341 147668 63947052
Asthenia 39.81 9.87 2234 401778 425810 63668910
Anxiety 39.66 9.87 966 403046 201683 63893037
Red blood cell sedimentation rate 39.63 9.87 78 403934 3636 64091084
Pulmonary arterial hypertension 39.51 9.87 61 403951 25306 64069414
Disturbance in attention 39.25 9.87 129 403883 40945 64053775
Abnormal behaviour 39.20 9.87 96 403916 33526 64061194
Neurotoxicity 38.88 9.87 70 403942 27334 64067386
Disability 38.64 9.87 165 403847 12007 64082713
Substance abuse 38.57 9.87 6 404006 9286 64085434
Poor venous access 38.40 9.87 167 403845 12250 64082470
Aspergillus infection 38.24 9.87 28 403984 16351 64078369
Blood creatine phosphokinase increased 38.06 9.87 213 403799 58345 64036375
Premature rupture of membranes 38.00 9.87 77 403935 3667 64091053
Joint range of motion decreased 37.96 9.87 229 403783 19114 64075606
Laryngitis 37.73 9.87 153 403859 10878 64083842
Cognitive disorder 37.67 9.87 197 403815 54890 64039830
Neutrophil count decreased 37.57 9.87 306 403706 76890 64017830
Ventricular tachycardia 37.51 9.87 101 403911 34164 64060556
Metabolic acidosis 37.48 9.87 275 403737 70683 64024037
Premature labour 37.45 9.87 119 403893 7501 64087219
Diabetic ketoacidosis 37.38 9.87 82 403930 29763 64064957
Pulmonary embolism 37.38 9.87 668 403344 145688 63949032
Smear cervix abnormal 37.18 9.87 59 403953 2315 64092405
Dizziness 36.96 9.87 2262 401750 427901 63666819
Posterior reversible encephalopathy syndrome 36.88 9.87 54 403958 22892 64071828
Nausea 36.42 9.87 4339 399673 781461 63313259
Hyperkalaemia 36.15 9.87 432 403580 100697 63994023
Second primary malignancy 36.09 9.87 16 403996 12321 64082399
Encephalopathy 36.06 9.87 218 403794 58601 64036119
Anaphylactic shock 35.83 9.87 86 403926 30242 64064478
Asphyxia 35.82 9.87 8 404004 9558 64085162
Arthritis infective 35.67 9.87 111 403901 6919 64087801
Product quality issue 35.60 9.87 84 403928 29715 64065005
Asthma 35.51 9.87 403 403609 94822 63999898
Multiple sclerosis relapse 35.42 9.87 135 403877 41000 64053720
Angioedema 35.40 9.87 234 403778 61587 64033133
Oral herpes 35.37 9.87 249 403763 21903 64072817
Restlessness 35.28 9.87 129 403883 39656 64055064
Cerebral infarction 35.15 9.87 135 403877 40909 64053811
Blood glucose increased 35.04 9.87 419 403593 97654 63997066
Multiple fractures 35.04 9.87 100 403912 5940 64088780
Speech disorder 34.96 9.87 170 403842 48271 64046449
Tuberculosis 34.86 9.87 168 403844 12870 64081850
Latent tuberculosis 34.52 9.87 62 403950 2695 64092025
Mobility decreased 34.39 9.87 741 403271 85099 64009621
Mental status changes 34.27 9.87 233 403779 60929 64033791
Torsade de pointes 34.08 9.87 35 403977 17328 64077392
Pathogen resistance 34.05 9.87 18 403994 12525 64082195
Dehydration 33.98 9.87 1066 402946 215697 63879023
Unresponsive to stimuli 33.46 9.87 182 403830 50211 64044509
Fluid retention 33.44 9.87 227 403785 59379 64035341
Irritability 33.35 9.87 118 403894 36628 64058092
Bone disorder 33.26 9.87 199 403813 16560 64078160
Transplant rejection 33.12 9.87 36 403976 17365 64077355
Rash maculo-papular 32.81 9.87 167 403845 46859 64047861
Wheelchair user 32.79 9.87 83 403929 4589 64090131
Diarrhoea 32.78 9.87 3996 400016 718708 63376012
Ventricular fibrillation 32.04 9.87 63 403949 23797 64070923
Spinal stenosis 31.99 9.87 172 403840 13759 64080961
Ejection fraction decreased 31.89 9.87 84 403928 28623 64066097
Influenza 31.67 9.87 883 403129 105648 63989072
Ear infection 31.67 9.87 253 403759 23151 64071569
Hallucination 31.67 9.87 297 403715 72491 64022229
Accidental overdose 31.64 9.87 106 403906 33451 64061269
Bronchopulmonary aspergillosis 31.58 9.87 44 403968 19041 64075679
Delirium 31.55 9.87 279 403733 68915 64025805
Fear of injection 31.54 9.87 95 403917 5817 64088903
Haematotoxicity 31.49 9.87 21 403991 12875 64081845
Vision blurred 31.45 9.87 388 403624 89928 64004792
No adverse event 31.41 9.87 84 403928 28477 64066243
Product administration error 31.39 9.87 80 403932 27563 64067157
Acute graft versus host disease 31.31 9.87 9 404003 9075 64085645
Unintentional medical device removal 31.25 9.87 3 404009 6731 64087989
Pancytopenia 31.15 9.87 1144 402868 142165 63952555
Disorientation 31.12 9.87 213 403799 55615 64039105
Tenosynovitis stenosans 31.10 9.87 49 403963 1911 64092809
Coronary artery disease 31.06 9.87 236 403776 60197 64034523
Arrhythmia 31.02 9.87 199 403813 52745 64041975
Hypokalaemia 30.93 9.87 557 403455 121346 63973374
Ischaemic stroke 30.73 9.87 87 403925 28948 64065772
Aggression 30.68 9.87 167 403845 46065 64048655
Melaena 30.50 9.87 203 403809 53345 64041375
Immunodeficiency 30.44 9.87 189 403823 15935 64078785
Neuroleptic malignant syndrome 30.23 9.87 70 403942 24926 64069794
Proteinuria 30.14 9.87 82 403930 27641 64067079
Bronchitis 30.03 9.87 893 403119 107850 63986870
Therapeutic response decreased 29.79 9.87 476 403536 51712 64043008
Osteonecrosis of jaw 29.77 9.87 138 403874 39687 64055033
Cytokine release syndrome 29.73 9.87 53 403959 20776 64073944
Skin cancer 29.67 9.87 151 403861 11823 64082897
Forced expiratory volume decreased 29.52 9.87 4 404008 6863 64087857
Bradyphrenia 29.46 9.87 11 404001 9395 64085325
Agranulocytosis 29.46 9.87 131 403881 38098 64056622
Mouth ulceration 29.44 9.87 322 403690 32122 64062598
Status epilepticus 29.26 9.87 57 403955 21606 64073114
Akathisia 29.12 9.87 18 403994 11492 64083228
Skin papilloma 29.08 9.87 85 403927 5118 64089602
Withdrawal syndrome 29.05 9.87 65 403947 23427 64071293
Malignant melanoma 29.05 9.87 159 403853 12805 64081915
Respiratory distress 29.00 9.87 200 403812 52131 64042589
Thrombotic microangiopathy 28.98 9.87 37 403975 16618 64078102
Pulmonary oedema 28.92 9.87 334 403678 78340 64016380
Rotator cuff repair 28.82 9.87 41 403971 1458 64093262
Injection site warmth 28.76 9.87 163 403849 13299 64081421
Tachypnoea 28.58 9.87 79 403933 26492 64068228
Surgery 28.42 9.87 286 403726 27927 64066793
Foot fracture 28.35 9.87 203 403809 17954 64076766
Blood cholesterol increased 28.34 9.87 456 403556 49610 64045110
Pyrexia 28.11 9.87 3067 400945 555577 63539143
Graft versus host disease 28.08 9.87 27 403985 13786 64080934
Joint noise 27.91 9.87 62 403950 3149 64091571
Blood creatinine increased 27.73 9.87 643 403369 135139 63959581
Foetal death 27.69 9.87 91 403921 5839 64088881
Gastroenteritis viral 27.65 9.87 215 403797 19514 64075206
Atrial fibrillation 27.63 9.87 838 403174 170251 63924469
Hyperthermia 27.62 9.87 34 403978 15516 64079204
Drug ineffective for unapproved indication 27.57 9.87 101 403911 31032 64063688
Suicidal ideation 27.47 9.87 275 403737 66267 64028453
Synovial fluid analysis 27.39 9.87 41 403971 1528 64093192
Creatinine renal clearance decreased 27.27 9.87 30 403982 14391 64080329
Drug level increased 27.07 9.87 116 403896 34080 64060640
Pleural effusion 27.07 9.87 595 403417 125964 63968756
Hypothermia 27.04 9.87 52 403960 19804 64074916
Hypertransaminasaemia 26.95 9.87 6 404006 7185 64087535
Psychotic disorder 26.94 9.87 118 403894 34460 64060260
Emotional distress 26.87 9.87 125 403887 35913 64058807
Coagulopathy 26.69 9.87 106 403906 31814 64062906
Cyst 26.61 9.87 147 403865 11880 64082840
Lupus-like syndrome 26.25 9.87 117 403895 8674 64086046
BK virus infection 26.19 9.87 7 404005 7405 64087315
Erythema multiforme 26.17 9.87 36 403976 15665 64079055
Myoclonus 26.04 9.87 76 403936 25042 64069678
Loose body in joint 25.95 9.87 35 403977 1183 64093537
Extrapyramidal disorder 25.93 9.87 52 403960 19500 64075220
Seizure 25.84 9.87 822 403190 166070 63928650
Anaphylactic reaction 25.83 9.87 290 403722 68374 64026346
Cardiogenic shock 25.67 9.87 110 403902 32317 64062403
Maternal exposure timing unspecified 25.51 9.87 54 403958 2653 64092067
Acute chest syndrome 25.36 9.87 30 403982 886 64093834
Respiratory disorder 25.33 9.87 128 403884 35983 64058737
Psychomotor hyperactivity 25.25 9.87 32 403980 14419 64080301
Gastrointestinal haemorrhage 25.25 9.87 633 403379 131679 63963041
Ulcer 25.09 9.87 237 403775 22753 64071967
Blood parathyroid hormone decreased 25.06 9.87 102 403910 7264 64087456
Dysgeusia 25.00 9.87 182 403830 46865 64047855
Wrong technique in product usage process 25.00 9.87 273 403739 64701 64030019
Haemoptysis 24.99 9.87 192 403820 48856 64045864
Drug use disorder 24.93 9.87 4 404008 6050 64088670
Graft versus host disease in gastrointestinal tract 24.77 9.87 3 404009 5609 64089111
White blood cell count decreased 24.53 9.87 777 403235 157060 63937660
Chronic kidney disease 24.48 9.87 238 403774 57681 64037039
Balance disorder 24.39 9.87 374 403638 83552 64011168
Drug hypersensitivity 24.15 9.87 1230 402782 236585 63858135
Febrile bone marrow aplasia 24.07 9.87 21 403991 11234 64083486
Fracture delayed union 24.04 9.87 44 403968 1941 64092779
Eosinophilia 23.93 9.87 140 403872 37936 64056784
Loss of consciousness 23.88 9.87 727 403285 147638 63947082
Shock haemorrhagic 23.72 9.87 43 403969 16748 64077972
Haemoglobin decreased 23.54 9.87 1469 402543 193594 63901126
Exostosis 23.46 9.87 137 403875 11301 64083419
Polyhydramnios 23.35 9.87 37 403975 1450 64093270
Postoperative wound infection 23.32 9.87 127 403885 10209 64084511
Scleritis 23.27 9.87 55 403957 2911 64091809
Rhinorrhoea 23.17 9.87 515 403497 59454 64035266
Paradoxical drug reaction 23.15 9.87 5 404007 6115 64088605
Post procedural infection 23.07 9.87 120 403892 9477 64085243
Cerebrovascular accident 22.93 9.87 671 403341 136912 63957808
Stress cardiomyopathy 22.71 9.87 15 403997 9242 64085478
Miosis 22.54 9.87 30 403982 13236 64081484
Pemphigoid 22.44 9.87 29 403983 12957 64081763
Antinuclear antibody positive 22.43 9.87 88 403924 6162 64088558
Clostridium difficile colitis 22.38 9.87 91 403921 27132 64067588
Tumour lysis syndrome 22.28 9.87 56 403956 19384 64075336
Bronchospasm 22.19 9.87 66 403946 21616 64073104
Inappropriate antidiuretic hormone secretion 21.99 9.87 69 403943 22220 64072500
Acute respiratory distress syndrome 21.97 9.87 148 403864 38787 64055933
Dry eye 21.90 9.87 278 403734 28741 64065979
Intentional product use issue 21.87 9.87 766 403246 94598 64000122
Mania 21.87 9.87 43 403969 16243 64078477
Blood alkaline phosphatase increased 21.84 9.87 236 403776 56043 64038677
Acute myeloid leukaemia 21.83 9.87 93 403919 27370 64067350
Hyperuricaemia 21.81 9.87 19 403993 10172 64084548
Glycosylated haemoglobin increased 21.77 9.87 42 403970 15977 64078743
Chest discomfort 21.74 9.87 557 403455 115549 63979171
Ascites 21.72 9.87 266 403746 61735 64032985
Acute generalised exanthematous pustulosis 21.71 9.87 34 403978 14024 64080696
Acute respiratory failure 21.61 9.87 204 403808 49730 64044990
Vertigo 21.50 9.87 251 403761 58760 64035960
Muscle spasms 21.49 9.87 696 403316 140327 63954393
Oxygen saturation decreased 21.48 9.87 848 403164 106328 63988392
Exposure to toxic agent 21.42 9.87 6 404006 6153 64088567
Granuloma skin 21.38 9.87 85 403927 5989 64088731
Aphasia 21.37 9.87 159 403853 40747 64053973
Panniculitis 21.33 9.87 111 403901 8768 64085952
Pulmonary tuberculosis 21.32 9.87 96 403916 7148 64087572
Depression 21.19 9.87 935 403077 182356 63912364
Lipase increased 21.15 9.87 36 403976 14366 64080354
Endophthalmitis 21.09 9.87 4 404008 5361 64089359
Chest pain 21.09 9.87 1236 402776 234744 63859976
Pulmonary alveolar haemorrhage 21.03 9.87 18 403994 9720 64085000
Pain in jaw 21.01 9.87 159 403853 40596 64054124
Platelet count decreased 20.96 9.87 848 403164 166863 63927857
Stevens-Johnson syndrome 20.96 9.87 127 403885 34122 64060598
Fear 20.94 9.87 61 403951 20110 64074610
Face oedema 20.84 9.87 82 403930 24679 64070041
Rebound effect 20.81 9.87 3 404009 4914 64089806
Aspartate aminotransferase increased 20.77 9.87 581 403431 119207 63975513
Dysarthria 20.76 9.87 255 403757 59151 64035569
Pharyngitis streptococcal 20.57 9.87 108 403904 8560 64086160
Respiration abnormal 20.44 9.87 7 404005 6308 64088412
Pancreatitis 20.40 9.87 257 403755 59350 64035370
Cardiac failure acute 20.39 9.87 45 403967 16299 64078421
Deep vein thrombosis 20.39 9.87 502 403510 104680 63990040
Metastases to bone 20.35 9.87 63 403949 20372 64074348
Pancreatitis acute 20.34 9.87 171 403841 42684 64052036
Adenovirus infection 20.31 9.87 10 404002 7245 64087475
Chronic graft versus host disease 20.23 9.87 7 404005 6269 64088451
Oliguria 20.00 9.87 38 403974 14538 64080182
Nocardiosis 19.97 9.87 3 404009 4764 64089956
Stillbirth 19.97 9.87 59 403953 3574 64091146
Haemophagocytic lymphohistiocytosis 19.96 9.87 51 403961 17558 64077162
Anuria 19.94 9.87 57 403955 18907 64075813
Acute graft versus host disease in skin 19.88 9.87 9 404003 6846 64087874
Dactylitis 19.84 9.87 40 403972 1898 64092822
Synovial disorder 19.83 9.87 27 403985 921 64093799
Gamma-glutamyltransferase increased 19.81 9.87 201 403811 48309 64046411
Cytopenia 19.80 9.87 42 403970 15429 64079291
Klebsiella infection 19.68 9.87 33 403979 13248 64081472
Weight decreased 19.67 9.87 2061 401951 283678 63811042
Breast feeding 19.59 9.87 23 403989 674 64094046
Joint dislocation 19.56 9.87 131 403881 11334 64083386
Adverse event 19.56 9.87 352 403660 39137 64055583
Device use error 19.55 9.87 8 404004 6463 64088257
Toxic skin eruption 19.52 9.87 59 403953 19225 64075495
Blood bilirubin increased 19.38 9.87 249 403763 57304 64037416
Cystitis haemorrhagic 19.37 9.87 13 403999 7943 64086777
Sepsis 19.25 9.87 1214 402798 229127 63865593
Endodontic procedure 19.24 9.87 44 403968 2279 64092441
Incorrect route of product administration 19.08 9.87 78 403934 23220 64071500
Metastases to lung 19.07 9.87 42 403970 15222 64079498
Bone pain 19.06 9.87 198 403814 47374 64047346
Tooth abscess 19.00 9.87 150 403862 13676 64081044
Dermatitis acneiform 18.99 9.87 15 403997 8428 64086292
Cytomegalovirus viraemia 18.89 9.87 24 403988 10804 64083916
Potentiating drug interaction 18.89 9.87 13 403999 7839 64086881
Cyanosis 18.89 9.87 73 403939 22082 64072638
Haemorrhage 18.75 9.87 367 403645 78984 64015736
Anhedonia 18.57 9.87 36 403976 13670 64081050
Decreased gait velocity 18.52 9.87 12 404000 152 64094568
Flushing 18.51 9.87 364 403648 78284 64016436
Blood pressure decreased 18.50 9.87 405 403607 85794 64008926
Normal newborn 18.49 9.87 77 403935 5540 64089180
Bursitis 18.47 9.87 211 403801 21274 64073446
Colitis ulcerative 18.41 9.87 223 403789 22805 64071915
Muscle spasticity 18.35 9.87 49 403963 16620 64078100
Pulmonary hypertension 18.34 9.87 177 403835 42962 64051758
Haemorrhage intracranial 18.31 9.87 82 403930 23802 64070918
Progressive multifocal leukoencephalopathy 18.30 9.87 56 403956 18176 64076544
Off label use 18.18 9.87 3592 400420 629214 63465506
Foetal distress syndrome 18.13 9.87 18 403994 434 64094286
Human antichimeric antibody positive 17.93 9.87 32 403980 1384 64093336
Angina pectoris 17.91 9.87 188 403824 44893 64049827
Metastases to liver 17.87 9.87 83 403929 23858 64070862
Device difficult to use 17.85 9.87 21 403991 9777 64084943
Electrocardiogram QRS complex prolonged 17.73 9.87 19 403993 9225 64085495
Subdural haematoma 17.71 9.87 103 403909 27951 64066769
Epstein-Barr virus infection 17.62 9.87 32 403980 12456 64082264
Haemorrhage in pregnancy 17.61 9.87 30 403982 1250 64093470
Induced labour 17.55 9.87 24 403988 822 64093898
Alcoholic liver disease 17.53 9.87 19 403993 509 64094211
Dyspnoea exertional 17.42 9.87 341 403671 73389 64021331
Ingrown hair 17.41 9.87 20 403992 572 64094148
Labelled drug-drug interaction medication error 17.36 9.87 75 403937 21987 64072733
Leukocytosis 17.28 9.87 152 403860 37588 64057132
Renal injury 17.25 9.87 45 403967 15384 64079336
Hyperammonaemia 17.23 9.87 22 403990 9882 64084838
Serum ferritin increased 17.09 9.87 101 403911 8367 64086353
Affective disorder 17.06 9.87 10 404002 6570 64088150
Placental disorder 17.03 9.87 24 403988 846 64093874
Spinal disorder 16.95 9.87 103 403909 8619 64086101
Interstitial lung disease 16.95 9.87 474 403538 97258 63997462
Cardiac failure chronic 16.88 9.87 19 403993 9022 64085698
Lacrimal disorder 16.88 9.87 18 403994 473 64094247
Injection site urticaria 16.88 9.87 124 403888 11057 64083663
Cushingoid 16.87 9.87 93 403919 7510 64087210
Musculoskeletal disorder 16.84 9.87 179 403833 17727 64076993
Palpitations 16.81 9.87 512 403500 103976 63990744
Hyperbilirubinaemia 16.74 9.87 72 403940 21133 64073587
Nephropathy toxic 16.73 9.87 55 403957 17459 64077261
Persecutory delusion 16.56 9.87 3 404009 4155 64090565
Sexual dysfunction 16.54 9.87 10 404002 6461 64088259
Maternal exposure during breast feeding 16.49 9.87 38 403974 1978 64092742
Bone density abnormal 16.46 9.87 46 403966 2699 64092021
Mass 16.43 9.87 157 403855 15119 64079601
Encephalitis toxic 16.37 9.87 14 403998 277 64094443
Acute myocardial infarction 16.30 9.87 323 403689 69395 64025325
Haematocrit decreased 16.23 9.87 453 403559 54202 64040518
Blood lactic acid increased 16.21 9.87 25 403987 10376 64084344
Tooth infection 16.17 9.87 151 403861 14450 64080270
Kidney infection 16.16 9.87 177 403835 17661 64077059
Arthritis bacterial 16.15 9.87 94 403918 7745 64086975
Gastric haemorrhage 16.10 9.87 38 403974 13443 64081277
Heart rate irregular 16.01 9.87 251 403761 27162 64067558
Osteopenia 15.88 9.87 158 403854 15382 64079338
Eye infection 15.81 9.87 106 403906 9175 64085545
Cystitis 15.70 9.87 364 403648 42311 64052409
Coronary arterial stent insertion 15.70 9.87 8 404004 5684 64089036
Body height below normal 15.69 9.87 35 403977 1783 64092937
Hepatitis fulminant 15.61 9.87 10 404002 6264 64088456
Hallucination, visual 15.61 9.87 106 403906 27728 64066992
Venoocclusive disease 15.61 9.87 3 404009 3982 64090738
Joint lock 15.58 9.87 46 403966 2785 64091935
Immunosuppression 15.55 9.87 118 403894 10628 64084092
Dislocation of vertebra 15.55 9.87 49 403963 3075 64091645
Placental insufficiency 15.50 9.87 25 403987 995 64093725
Pulmonary congestion 15.44 9.87 87 403925 23793 64070927
Pleuritic pain 15.35 9.87 95 403917 8001 64086719
Disease recurrence 15.28 9.87 125 403887 31385 64063335
Tubulointerstitial nephritis 15.27 9.87 122 403890 30787 64063933
Paralysis 15.24 9.87 31 403981 11564 64083156
Gestational hypertension 15.23 9.87 33 403979 1648 64093072
Hypoalbuminaemia 15.22 9.87 58 403954 17616 64077104
Oedema 15.15 9.87 449 403563 91486 64003234
Wound infection 15.13 9.87 151 403861 14713 64080007
Sinus bradycardia 15.02 9.87 83 403929 22810 64071910
Tooth disorder 14.99 9.87 210 403802 22192 64072528
Cellulitis 14.98 9.87 724 403288 92933 64001787
Lymphatic fistula 14.97 9.87 21 403991 737 64093983
Cytomegalovirus chorioretinitis 14.96 9.87 6 404006 4906 64089814
Frequent bowel movements 14.95 9.87 178 403834 18127 64076593
Wound infection pseudomonas 14.93 9.87 31 403981 1502 64093218
Femoral hernia incarcerated 14.91 9.87 21 403991 740 64093980
Upper respiratory tract infection 14.84 9.87 577 403435 72208 64022512
Temperature regulation disorder 14.83 9.87 4 404008 4207 64090513
Hyperthyroidism 14.80 9.87 61 403951 18118 64076602
Arthropod bite 14.77 9.87 82 403930 6639 64088081
Obstructive airways disorder 14.70 9.87 85 403927 23100 64071620
Ileus 14.67 9.87 84 403928 22882 64071838
Dermatitis allergic 14.66 9.87 152 403860 14957 64079763
End stage renal disease 14.64 9.87 27 403985 10448 64084272
Sinus tachycardia 14.58 9.87 130 403882 32058 64062662
Adjustment disorder with depressed mood 14.56 9.87 41 403971 2416 64092304
Cervical incompetence 14.56 9.87 17 403995 495 64094225
Right ventricular failure 14.55 9.87 77 403935 21394 64073326
Acute coronary syndrome 14.38 9.87 67 403945 19243 64075477
Pulseless electrical activity 14.36 9.87 37 403975 12702 64082018
Coordination abnormal 14.29 9.87 47 403965 14917 64079803
Lung transplant 14.29 9.87 4 404008 4104 64090616
Enterocolitis 14.26 9.87 34 403978 11984 64082736
Tuberculin test positive 14.25 9.87 47 403965 3021 64091699
Myelosuppression 14.25 9.87 89 403923 23741 64070979
Polyneuropathy 14.25 9.87 70 403942 19824 64074896
Dyskinesia 14.17 9.87 168 403844 39220 64055500
Hepatotoxicity 14.16 9.87 171 403841 39791 64054929
Iodine allergy 14.14 9.87 17 403995 511 64094209
Graft versus host disease in skin 14.04 9.87 8 404004 5339 64089381
Delivery 14.01 9.87 17 403995 516 64094204
Blood calcium decreased 13.99 9.87 98 403914 25456 64069264
Insomnia 13.99 9.87 1058 402954 196778 63897942
Malignant mediastinal neoplasm 13.98 9.87 17 403995 517 64094203
International normalised ratio increased 13.97 9.87 383 403629 78784 64015936
Abortion threatened 13.95 9.87 15 403997 398 64094322
Toothache 13.92 9.87 169 403843 17290 64077430
Sickle cell anaemia 13.91 9.87 18 403994 584 64094136
Cardiotoxicity 13.91 9.87 27 403985 10247 64084473
Skin neoplasm excision 13.85 9.87 22 403990 864 64093856
Pneumonia bacterial 13.83 9.87 48 403964 14987 64079733
Metastases to central nervous system 13.77 9.87 43 403969 13869 64080851
Transplant dysfunction 13.77 9.87 13 403999 6695 64088025
Type 2 diabetes mellitus 13.72 9.87 294 403718 33726 64060994
Pleural fibrosis 13.71 9.87 56 403956 3994 64090726
Injection site haemorrhage 13.69 9.87 221 403791 24057 64070663
Presyncope 13.67 9.87 147 403865 34942 64059778
Unevaluable event 13.66 9.87 228 403784 50261 64044459
Peripheral sensory neuropathy 13.65 9.87 32 403980 11346 64083374
Clear cell renal cell carcinoma 13.55 9.87 37 403975 2142 64092578
Ankle arthroplasty 13.49 9.87 22 403990 884 64093836
Hypercapnia 13.48 9.87 17 403995 7677 64087043
Rheumatoid lung 13.38 9.87 40 403972 2439 64092281
Stress at work 13.37 9.87 23 403989 966 64093754
Pulmonary haemorrhage 13.35 9.87 40 403972 13069 64081651
Nightmare 13.29 9.87 77 403935 20916 64073804
Polyuria 13.29 9.87 38 403974 12605 64082115
Sarcopenia 13.28 9.87 14 403998 363 64094357
Small for dates baby 13.20 9.87 15 403997 424 64094296
Cholestasis of pregnancy 13.15 9.87 22 403990 903 64093817
Antibody test positive 13.14 9.87 39 403973 2368 64092352
Knee operation 13.12 9.87 60 403952 4497 64090223
Lip swelling 13.11 9.87 132 403880 31775 64062945
Drug screen positive 13.11 9.87 10 404002 5719 64089001
Aphthous ulcer 13.08 9.87 131 403881 12775 64081945
Joint warmth 13.06 9.87 28 403984 1388 64093332
Pancreatic steatosis 13.05 9.87 23 403989 985 64093735
Peritoneal dialysis complication 13.03 9.87 37 403975 2191 64092529
Visual acuity reduced 13.01 9.87 108 403904 27033 64067687
Feeling abnormal 12.98 9.87 694 403318 132908 63961812
Palindromic rheumatism 12.97 9.87 13 403999 317 64094403
Hemiplegia 12.97 9.87 39 403973 12729 64081991
Human anti-human antibody test 12.95 9.87 14 403998 374 64094346
Hepatic cytolysis 12.82 9.87 45 403967 14004 64080716
Virologic failure 12.77 9.87 3 404009 3463 64091257
Myofascial pain syndrome 12.68 9.87 32 403980 1766 64092954
Oesophageal fibrosis 12.66 9.87 10 404002 176 64094544
Postpartum haemorrhage 12.65 9.87 28 403984 1419 64093301
Breast abscess 12.64 9.87 24 403988 1089 64093631
Amylase increased 12.64 9.87 26 403986 9659 64085061
Atrioventricular block complete 12.62 9.87 47 403965 14371 64080349
Injection site discolouration 12.61 9.87 80 403932 6795 64087925
Finger deformity 12.57 9.87 65 403947 5121 64089599
Increased tendency to bruise 12.50 9.87 100 403912 9155 64085565
Drug specific antibody 12.46 9.87 35 403977 2060 64092660
Complication of device insertion 12.46 9.87 8 404004 5004 64089716
Tendon disorder 12.45 9.87 75 403937 6257 64088463
Colitis microscopic 12.43 9.87 17 403995 7415 64087305
Respiratory acidosis 12.41 9.87 27 403985 9828 64084892
Sciatica 12.39 9.87 187 403825 20077 64074643
Injection site extravasation 12.39 9.87 90 403922 7996 64086724
Osteoporotic fracture 12.38 9.87 50 403962 3548 64091172
Eosinophil count increased 12.35 9.87 46 403966 14066 64080654
Memory impairment 12.31 9.87 426 403586 85256 64009464
Hypertriglyceridaemia 12.29 9.87 33 403979 11172 64083548
Uterine perforation 12.28 9.87 11 404001 5809 64088911
Intervertebral disc degeneration 12.27 9.87 131 403881 12989 64081731
C-reactive protein decreased 12.24 9.87 35 403977 2081 64092639
Drug abuser 12.22 9.87 11 404001 5797 64088923
Nephrotic syndrome 12.22 9.87 26 403986 9541 64085179
Foetal exposure during pregnancy 12.20 9.87 58 403954 4418 64090302
Red blood cell count decreased 12.20 9.87 393 403619 47993 64046727
Genital haemorrhage 12.18 9.87 10 404002 5512 64089208
Pneumatosis intestinalis 12.13 9.87 9 404003 5220 64089500
Viral mutation identified 12.13 9.87 3 404009 3343 64091377
Mean cell volume increased 12.06 9.87 63 403949 4983 64089737
Kidney transplant rejection 12.02 9.87 26 403986 9485 64085235
Bradykinesia 12.02 9.87 14 403998 6546 64088174
Hemiparesis 12.01 9.87 124 403888 29703 64065017
Atrioventricular block 11.99 9.87 37 403975 11978 64082742
Blood folate increased 11.99 9.87 15 403997 470 64094250
Lymphocyte count decreased 11.95 9.87 181 403831 40518 64054202
Haematuria 11.88 9.87 288 403724 60183 64034537
Prostatic specific antigen increased 11.87 9.87 23 403989 8737 64085983
Transaminases increased 11.86 9.87 202 403810 44392 64050328
Myocardial ischaemia 11.85 9.87 91 403921 23160 64071560
Chondropathy 11.83 9.87 37 403975 2312 64092408
Bradypnoea 11.81 9.87 9 404003 5150 64089570
Skin ulcer haemorrhage 11.77 9.87 15 403997 479 64094241
Abortion missed 11.77 9.87 24 403988 1148 64093572
Starvation ketoacidosis 11.73 9.87 8 404004 111 64094609
Lower respiratory tract congestion 11.71 9.87 43 403969 2918 64091802
Cholangitis 11.70 9.87 32 403980 10770 64083950
Sinus congestion 11.69 9.87 148 403864 15291 64079429
Threatened labour 11.68 9.87 16 403996 549 64094171
Hyperlactacidaemia 11.68 9.87 8 404004 4836 64089884
Intracranial pressure increased 11.67 9.87 16 403996 6973 64087747
Drug-induced liver injury 11.67 9.87 219 403793 47424 64047296
Myopathy 11.65 9.87 64 403948 17616 64077104
Foot operation 11.63 9.87 55 403957 4180 64090540
Retinitis 11.59 9.87 34 403978 2051 64092669
Dystonia 11.52 9.87 70 403942 18795 64075925
Spinal osteoarthritis 11.51 9.87 139 403873 14202 64080518
Hernia pain 11.51 9.87 14 403998 426 64094294
Pneumothorax 11.51 9.87 97 403915 24201 64070519
Anger 11.50 9.87 55 403957 15686 64079034
Ileus paralytic 11.49 9.87 22 403990 8393 64086327
Anal fistula 11.48 9.87 64 403948 5189 64089531
Ventricular arrhythmia 11.39 9.87 18 403994 7397 64087323
Hiatus hernia 11.38 9.87 182 403830 19775 64074945
Pharyngitis 11.37 9.87 175 403837 18864 64075856
Hallucination, auditory 11.34 9.87 61 403951 16878 64077842
Blood iron increased 11.31 9.87 26 403986 1351 64093369
Hernia 11.28 9.87 132 403880 13386 64081334
Personality change 11.27 9.87 23 403989 8570 64086150
Abdominal distension 11.22 9.87 489 403523 95505 63999215
Bacteraemia 11.20 9.87 111 403901 26800 64067920
Peripheral venous disease 11.17 9.87 73 403939 6265 64088455
Tooth fracture 11.17 9.87 103 403909 9824 64084896
Erectile dysfunction 11.16 9.87 41 403971 12586 64082134
Labyrinthitis 11.14 9.87 39 403973 2584 64092136
Cirrhosis alcoholic 11.12 9.87 21 403991 949 64093771
Pseudomonas infection 11.11 9.87 66 403946 17817 64076903
Coronary artery bypass 11.10 9.87 12 404000 5803 64088917
Diabetes mellitus inadequate control 11.08 9.87 83 403929 21238 64073482
Blood loss anaemia 11.07 9.87 47 403965 13845 64080875
Nephrolithiasis 11.06 9.87 355 403657 43328 64051392
Purpura 11.06 9.87 63 403949 17183 64077537
Hepatitis cholestatic 11.05 9.87 39 403973 12116 64082604
Vacuum extractor delivery 11.04 9.87 8 404004 123 64094597
Crying 11.02 9.87 77 403935 20013 64074707
Product prescribing error 11.00 9.87 155 403857 35114 64059606
Hypervolaemia 10.99 9.87 171 403841 38114 64056606
Skin graft failure 10.97 9.87 10 404002 216 64094504
Body mass index decreased 10.96 9.87 15 403997 514 64094206
Delusion 10.92 9.87 67 403945 17947 64076773
Haematoma 10.89 9.87 214 403798 46036 64048684
Device related infection 10.87 9.87 131 403881 30495 64064225
Lip blister 10.85 9.87 35 403977 2224 64092496
Laryngospasm 10.84 9.87 4 404008 3441 64091279
Skin laceration 10.83 9.87 214 403798 24203 64070517
Mesothelioma 10.82 9.87 12 404000 330 64094390
Immune thrombocytopenia 10.80 9.87 53 403959 15013 64079707
Swollen joint count 10.78 9.87 16 403996 592 64094128
Septic shock 10.75 9.87 545 403467 104892 63989828
Radiation inflammation 10.74 9.87 10 404002 222 64094498
Alanine aminotransferase increased 10.72 9.87 738 403274 138293 63956427
Nail injury 10.70 9.87 14 403998 459 64094261
Bundle branch block left 10.67 9.87 30 403982 10004 64084716
Medical device site joint infection 10.63 9.87 10 404002 225 64094495
Accidental death 10.63 9.87 5 404007 3720 64091000
Complications of transplanted kidney 10.62 9.87 11 404001 5424 64089296
Abortion incomplete 10.61 9.87 3 404009 3058 64091662
Acute lymphocytic leukaemia recurrent 10.60 9.87 6 404006 4020 64090700
Failure to anastomose 10.60 9.87 10 404002 226 64094494
Cataract 10.59 9.87 407 403605 50855 64043865
Umbilical hernia 10.53 9.87 55 403957 4350 64090370
Clavicle fracture 10.53 9.87 49 403963 3700 64091020
Pancreatic duct stenosis 10.49 9.87 10 404002 229 64094491
Vascular device infection 10.47 9.87 14 403998 6166 64088554
Sensitivity to weather change 10.44 9.87 75 403937 6639 64088081
Carpal tunnel syndrome 10.44 9.87 148 403864 15680 64079040
Catheter site erythema 10.43 9.87 9 404003 4840 64089880
Oligohydramnios 10.42 9.87 43 403969 3081 64091639
Failed induction of labour 10.38 9.87 10 404002 232 64094488
Catheter management 10.38 9.87 4 404008 3351 64091369
Benign ovarian tumour 10.38 9.87 11 404001 287 64094433
Haemodynamic instability 10.38 9.87 53 403959 14859 64079861
Acidosis 10.36 9.87 67 403945 17728 64076992
Transfusion reaction 10.34 9.87 28 403984 1613 64093107
Hospitalisation 10.33 9.87 376 403636 74831 64019889
Speech disorder developmental 10.33 9.87 15 403997 544 64094176
Impaired work ability 10.32 9.87 143 403869 15076 64079644
Skin necrosis 10.28 9.87 136 403876 14193 64080527
Salivary hypersecretion 10.27 9.87 40 403972 12073 64082647
Musculoskeletal discomfort 10.26 9.87 151 403861 16126 64078594
Incoherent 10.26 9.87 18 403994 7100 64087620
Hepatitis acute 10.24 9.87 46 403966 13343 64081377
Renal disorder 10.14 9.87 158 403854 35207 64059513
Hyperhomocysteinaemia 10.13 9.87 13 403999 418 64094302
Haemodialysis 10.10 9.87 64 403948 17013 64077707
Vascular insufficiency 10.10 9.87 14 403998 486 64094234
Aptyalism 10.09 9.87 17 403995 702 64094018
Ankylosing spondylitis 10.07 9.87 87 403925 8147 64086573
Acute graft versus host disease in intestine 10.06 9.87 5 404007 3604 64091116
Polydipsia 10.06 9.87 13 403999 5808 64088912
Decreased insulin requirement 10.03 9.87 8 404004 143 64094577
Generalised oedema 9.99 9.87 83 403929 20770 64073950
Anti-neutrophil cytoplasmic antibody positive vasculitis 9.95 9.87 3 404009 2933 64091787
Systemic inflammatory response syndrome 9.88 9.87 32 403980 10203 64084517

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11DA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12
Vitamin B1, plain
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:71692 insect repellents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Korsakoff's psychosis indication 69482004 DOID:10915
Pernicious anemia indication 84027009 DOID:13381
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Cobalamin deficiency indication 190634004
Thiamin deficiency indication 399357009 DOID:0070313
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Prevention of Vitamin B12 Deficiency indication
Methylmalonic acidemia off-label use 42393006
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Agoraphobia contraindication 70691001 DOID:593
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Panic disorder contraindication 371631005 DOID:594
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thiamine transporter 1 Transporter WOMBAT-PK
Transketolase Enzyme WOMBAT-PK
Thiamin pyrophosphokinase 1 Kinase WOMBAT-PK
Thiamine-triphosphatase Enzyme WOMBAT-PK
Transketolase-like protein 1 Enzyme WOMBAT-PK
Heat shock protein HSP 90-alpha Cytosolic other IC50 4.90 CHEMBL
Thiamine transporter ThiT Transporter Kd 9.91 CHEMBL

External reference:

IDSource
4017777 VUID
N0000146138 NUI
D08580 KEGG_DRUG
67-03-8 SECONDARY_CAS_RN
532-43-4 SECONDARY_CAS_RN
4017446 VANDF
4017474 VANDF
4017634 VANDF
4017777 VANDF
4021900 VANDF
C0039840 UMLSCUI
CHEBI:26948 CHEBI
VIB PDB_CHEM_ID
CHEMBL1547 ChEMBL_ID
CHEMBL1588 ChEMBL_ID
CHEMBL1200941 ChEMBL_ID
DB00152 DRUGBANK_ID
CHEMBL2104496 ChEMBL_ID
D013831 MESH_DESCRIPTOR_UI
C000712172 MESH_SUPPLEMENTAL_RECORD_UI
1130 PUBCHEM_CID
4629 IUPHAR_LIGAND_ID
432 INN_ID
X66NSO3N35 UNII
10454 RXNORM
1096 MMSL
15466 MMSL
41397 MMSL
5566 MMSL
5681 MMSL
7276 MMSL
d03130 MMSL
001061 NDDF
001062 NDDF
003860 NDDF
126228004 SNOMEDCT_US
126229007 SNOMEDCT_US
259659006 SNOMEDCT_US
30306003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 2 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 4.54 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 3 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 3 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 3 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 3 mg ORAL Unapproved drug other 11 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9963 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 11 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9963 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 11 sections
Thiamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0641-6228 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 15 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1.60 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1.10 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1.60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.60 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 20 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1.60 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 3 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 1.50 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 1.84 mg ORAL unapproved drug other 8 sections