venlafaxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2813 93413-69-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • venlafaxine
  • (+/-)-Venlafaxine
  • velafax
  • venlafaxin
  • venlafexine
  • venlafaxine hydrochloride
  • effexor
  • WY-45,030
  • venlafaxine HCl
A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.
  • Molecular weight: 277.41
  • Formula: C17H27NO2
  • CLOGP: 3.27
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.70
  • ALOGS: -3.08
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 31.39 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 4.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.59 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 45 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 14 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.73 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.608 Moderate 0.72
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.074 Moderate 0.72
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 24.604 10^-6 cm/s Moderate 0.72
dh-clint Dog hepatocyte intrinsic clearance 5.236 uL/min/10^6 cells Moderate 0.72
dppb Dog plasma protein binding (% unbound) 74.030 % Moderate 0.72
fcs-ppb Fetal calf serum protein binding (% unbound) 79.780 % Moderate 0.72
herg hERG pIC50 4.515 pIC50 Moderate 0.72
hh-clint Human hepatocyte intrinsic clearance 1.250 uL/min/10^6 cells Moderate 0.72
hlm-clint Human liver microsomal intrinsic clearance 3.034 uL/min/mg protein Moderate 0.72
hppb Human plasma protein binding (% unbound) 80.470 % Moderate 0.72
kinase-safety-class ACVR2A,ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAPK10,MAPK7,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,TEK,TGFBR1 27
kinase-selectivity-class AXL,BRAF,EIF2AK3,GRK2,PDK4 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.624 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.695 Moderate 0.72
mh-clint Mouse hepatocyte intrinsic clearance 20.989 Moderate 0.72
mppb Mouse plasma protein binding (% unbound) 71.620 Moderate 0.72
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.780 Moderate 0.72
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 75.850 % Moderate 0.72
rat-kpuu-brain Rat brain Kpuu 0.419 % High 1
rh-clint Rat hepatocyte intrinsic clearance 43.251 uL/min/10^6 cells Moderate 0.72
rh-fuinc Rat hepatocyte fraction unbound in incubation 87.900 % Moderate 0.72
rppb Rat plasma protein binding (% unbound) 78.830 % Moderate 0.72
solubility-dd Solubility at pH 7.4 in DMSO 941.890 uM Moderate 0.72

Approvals:

DateAgencyCompanyOrphan
Dec. 28, 1993 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2305.51 9.35 2331 232642 142727 90250747
Serotonin syndrome 1777.36 9.35 1149 233824 36738 90356736
Intentional overdose 1715.91 9.35 1629 233344 92205 90301269
Suicide attempt 1513.51 9.35 1379 233594 74020 90319454
Toxicity to various agents 1478.71 9.35 2663 232310 285183 90108291
Drug withdrawal syndrome 1398.79 9.35 892 234081 27831 90365643
Suicidal ideation 1305.95 9.35 1259 233714 72596 90320878
Overdose 1165.00 9.35 1721 233252 155988 90237486
Drug interaction 861.02 9.35 2084 232889 274369 90119105
Drug abuse 837.54 9.35 1050 233923 81297 90312177
Pemphigus 829.05 9.35 3 234970 326861 90066613
Intentional self-injury 736.69 9.35 610 234363 28724 90364750
Systemic lupus erythematosus 688.21 9.35 70 234903 361826 90031648
Hand deformity 687.80 9.35 17 234956 296345 90097129
Synovitis 667.23 9.35 49 234924 329703 90063771
Poisoning deliberate 657.13 9.35 452 234521 16034 90377440
Coma 643.09 9.35 865 234108 71767 90321707
Glossodynia 633.75 9.35 54 234919 321725 90071749
Withdrawal syndrome 621.76 9.35 495 234478 22029 90371445
Hyperhidrosis 603.61 9.35 1185 233788 135120 90258354
Anti-cyclic citrullinated peptide antibody positive 594.84 9.35 3 234970 236430 90157044
Pericarditis 586.48 9.35 27 234946 270124 90123350
Duodenal ulcer perforation 555.67 9.35 3 234970 221285 90172189
Somnolence 526.42 9.35 1456 233517 207628 90185846
Helicobacter infection 526.30 9.35 13 234960 226837 90166637
Wound 505.94 9.35 88 234885 302892 90090582
Agitation 487.28 9.35 727 234246 66371 90327103
Sopor 477.06 9.35 442 234531 24202 90369272
Mydriasis 475.53 9.35 358 234615 14654 90378820
Tremor 468.95 9.35 1148 233825 152025 90241449
Arthropathy 458.32 9.35 188 234785 366054 90027420
Folliculitis 441.59 9.35 21 234952 204332 90189142
Rheumatoid factor positive 418.01 9.35 5 234968 171645 90221829
Electrocardiogram QT prolonged 413.15 9.35 703 234270 71753 90321721
Muscle injury 410.20 9.35 10 234963 176644 90216830
Alopecia 401.60 9.35 415 234558 494656 89898818
Swelling 400.45 9.35 301 234672 418757 89974717
Rheumatic fever 379.67 9.35 3 234970 153118 90240356
Intentional product misuse 366.57 9.35 754 234219 88850 90304624
Impaired healing 363.63 9.35 81 234892 234118 90159356
Seizure 337.60 9.35 1015 233958 151614 90241860
Blister 325.22 9.35 127 234846 254871 90138603
Foetal exposure during pregnancy 324 9.35 474 234499 42501 90350973
Abdominal discomfort 312.82 9.35 471 234502 476857 89916617
Stomatitis 306.55 9.35 165 234808 274533 90118941
Discomfort 304.36 9.35 166 234807 274169 90119305
Crying 299.63 9.35 351 234622 25294 90368180
Generalised tonic-clonic seizure 294.14 9.35 406 234567 34497 90358977
Irritable bowel syndrome 292.80 9.35 87 234886 207361 90186113
Sleep disorder due to general medical condition, insomnia type 292.37 9.35 9 234964 128685 90264789
Anxiety 290.82 9.35 1576 233397 308196 90085278
Psoriatic arthropathy 290.70 9.35 114 234859 228221 90165253
Foetal death 288.94 9.35 311 234662 20412 90373062
Cardio-respiratory arrest 268.50 9.35 540 234433 62600 90330874
Mobility decreased 266.29 9.35 160 234813 250574 90142900
Depression 265.88 9.35 1505 233468 299096 90094378
Akathisia 261.43 9.35 223 234750 10936 90382538
Joint range of motion decreased 260.81 9.35 25 234948 135618 90257856
Ill-defined disorder 256.47 9.35 80 234893 184811 90208663
Contraindicated product administered 251.90 9.35 275 234698 319864 90073610
C-reactive protein abnormal 251.72 9.35 21 234952 127408 90266066
Therapeutic product effect decreased 250.33 9.35 211 234762 277360 90116114
Depressed mood 247.22 9.35 457 234516 49765 90343709
Selective eating disorder 234.55 9.35 112 234861 1941 90391533
Irritability 231.56 9.35 367 234606 35295 90358179
Cardiac arrest 231.15 9.35 697 234276 104238 90289236
Food allergy 230.83 9.35 307 234666 25171 90368303
Peripheral swelling 226.49 9.35 456 234517 412650 89980824
Joint swelling 225.28 9.35 619 234354 502681 89890793
Hypotonia neonatal 223.37 9.35 97 234876 1333 90392141
Disturbance in attention 221.07 9.35 420 234553 46689 90346785
Feeling abnormal 220.71 9.35 939 234034 166296 90227178
Temperature regulation disorder 216.02 9.35 226 234747 14353 90379121
Lip dry 212.89 9.35 12 234961 100943 90292531
Major depression 211.86 9.35 189 234784 9846 90383628
Cardiogenic shock 205.23 9.35 284 234689 24184 90369290
Nasopharyngitis 205.18 9.35 471 234502 406633 89986841
Breast cancer stage III 203.18 9.35 3 234970 84444 90309030
Infusion related reaction 203.02 9.35 491 234482 416289 89977185
Drug dependence 200.41 9.35 309 234664 29018 90364456
Nightmare 200.24 9.35 264 234709 21461 90372013
Aggression 199.34 9.35 293 234680 26375 90367099
Liver injury 193.81 9.35 100 234873 170467 90223007
Respiratory arrest 189.54 9.35 323 234650 32988 90360486
Wound infection 188.60 9.35 26 234947 106376 90287098
Extrapyramidal disorder 188.55 9.35 222 234751 16081 90377393
Facet joint syndrome 184.29 9.35 20 234953 98369 90295105
Gestational diabetes 184.21 9.35 179 234794 10403 90383071
Anger 182.71 9.35 201 234772 13519 90379955
Oedema 179.62 9.35 153 234820 200142 90193332
Panic attack 179.05 9.35 277 234696 26088 90367386
General physical health deterioration 178.77 9.35 411 234562 354704 90038770
Lower respiratory tract infection 175.19 9.35 236 234737 250423 90143051
Pneumonia 174.00 9.35 958 234015 637101 89756373
Restlessness 173.23 9.35 323 234650 35397 90358077
Sinus tachycardia 169.57 9.35 282 234691 28231 90365243
Altered state of consciousness 169.28 9.35 298 234675 31234 90362240
Small for dates baby 166.59 9.35 123 234850 4884 90388590
Lung disorder 164.24 9.35 92 234881 149791 90243683
Rash 163.84 9.35 1301 233672 794799 89598675
Gastrointestinal disorder 160.56 9.35 261 234712 256426 90137048
Psychomotor hyperactivity 157.43 9.35 180 234793 12633 90380841
Grip strength decreased 156.33 9.35 26 234947 92550 90300924
Mania 156.21 9.35 188 234785 13936 90379538
Musculoskeletal stiffness 155.10 9.35 336 234637 296196 90097278
C-reactive protein increased 154.91 9.35 145 234828 181244 90212230
Electrocardiogram QRS complex prolonged 154.34 9.35 138 234835 7210 90386264
Fibromyalgia 153.67 9.35 185 234788 206084 90187390
Product substitution issue 152.50 9.35 210 234763 17798 90375676
Wheezing 151.80 9.35 239 234734 237841 90155633
Tachycardia 148.26 9.35 803 234170 156870 90236604
Peripheral venous disease 147.57 9.35 21 234952 83900 90309574
Arthralgia 147.17 9.35 1301 233672 777221 89616253
Drug withdrawal syndrome neonatal 146.18 9.35 85 234888 2234 90391240
Injury 144.90 9.35 179 234794 197170 90196304
Disorientation 144.90 9.35 340 234633 43774 90349700
Sinusitis 144.51 9.35 434 234539 342654 90050820
Blood cholesterol increased 144.17 9.35 197 234776 207815 90185659
Atrial septal defect 140.92 9.35 138 234835 8096 90385378
Maternal exposure during pregnancy 140.77 9.35 471 234502 359592 90033882
Poisoning 140.37 9.35 185 234788 15032 90378442
Pulmonary fibrosis 136.21 9.35 54 234919 107449 90286025
Galactorrhoea 133.90 9.35 105 234868 4567 90388907
Hyperreflexia 133.87 9.35 122 234851 6535 90386939
Infection 131.94 9.35 488 234485 361606 90031868
Autoimmune disorder 128.59 9.35 22 234951 76722 90316752
Hypercholesterolaemia 127.30 9.35 51 234922 100841 90292633
Stress cardiomyopathy 127.29 9.35 165 234808 13190 90380284
Intentional product use issue 124.28 9.35 233 234740 216659 90176815
Osteoarthritis 124.27 9.35 197 234776 195533 90197941
Live birth 123.42 9.35 27 234946 79080 90314394
Immunodeficiency 122.65 9.35 315 234658 42919 90350555
Type 2 diabetes mellitus 120.32 9.35 214 234759 203030 90190444
Red blood cell sedimentation rate increased 119.50 9.35 33 234940 82562 90310912
Mood swings 119.44 9.35 202 234771 20500 90372974
Hip arthroplasty 118.92 9.35 26 234947 76182 90317292
Vertigo 118.05 9.35 424 234549 69387 90324087
Depressed level of consciousness 117.96 9.35 436 234537 72348 90321126
Bone erosion 115.94 9.35 5 234968 53016 90340458
Loss of consciousness 115.23 9.35 689 234284 139549 90253925
Gait inability 114.86 9.35 126 234847 146330 90247144
Mental disorder 113.77 9.35 256 234717 32062 90361412
Antidepressant drug level above therapeutic 113.25 9.35 44 234929 446 90393028
Adjustment disorder with depressed mood 113.04 9.35 9 234964 56744 90336730
Muscle rigidity 112.45 9.35 161 234812 14148 90379326
Myelosuppression 111.07 9.35 7 234966 53584 90339890
Abnormal dreams 110.30 9.35 141 234832 11116 90382358
Hyponatraemia 109.66 9.35 656 234317 132882 90260592
Mental impairment 107.06 9.35 171 234802 16549 90376925
Myoclonus 105.28 9.35 183 234790 18985 90374489
Hallucination 104.29 9.35 392 234581 65567 90327907
Inflammation 102.17 9.35 192 234781 178400 90215074
Hepatic enzyme increased 101.78 9.35 535 234438 360201 90033273
Tardive dyskinesia 101.00 9.35 133 234840 10797 90382677
Psychomotor retardation 100.70 9.35 90 234883 4699 90388775
Respiratory depression 99.33 9.35 159 234814 15416 90378058
Bradycardia neonatal 99.24 9.35 51 234922 1042 90392432
Neuroleptic malignant syndrome 98.87 9.35 156 234817 14940 90378534
Urticaria 97.92 9.35 447 234526 312287 90081187
Exposure during pregnancy 97.58 9.35 996 233977 237414 90156060
Treatment failure 97.21 9.35 431 234542 303497 90089977
Nail disorder 96.64 9.35 18 234955 59049 90334425
Antidepressant drug level increased 96.48 9.35 37 234936 361 90393113
Nervousness 95.44 9.35 247 234726 33809 90359665
Sleep-related eating disorder 94.50 9.35 48 234925 956 90392518
Apathy 93.87 9.35 129 234844 10911 90382563
Lower limb fracture 93.37 9.35 52 234921 84961 90308513
Parkinsonism 93.03 9.35 146 234827 13919 90379555
Musculoskeletal pain 92.87 9.35 190 234783 171061 90222413
Blepharospasm 92.66 9.35 16 234957 55429 90338045
Thinking abnormal 92.19 9.35 132 234841 11600 90381874
Febrile neutropenia 91.67 9.35 169 234804 158180 90235294
Hallucination, visual 91.65 9.35 192 234781 22900 90370574
Hyperprolactinaemia 91.01 9.35 90 234883 5343 90388131
Sedation 90.50 9.35 303 234670 47868 90345606
Drug ineffective for unapproved indication 90.00 9.35 377 234596 66267 90327207
Tearfulness 89.15 9.35 84 234889 4696 90388778
Hallucination, auditory 88.37 9.35 153 234820 15822 90377652
Bezoar 88.35 9.35 66 234907 2668 90390806
Paranoia 88.18 9.35 136 234837 12772 90380702
Liver disorder 87.93 9.35 111 234862 121158 90272316
Ventricular tachycardia 87.28 9.35 196 234777 24512 90368962
Pain 86.87 9.35 1946 233027 994395 89399079
Retinitis 86.22 9.35 3 234970 38455 90355019
Urinary incontinence 85.96 9.35 253 234720 37313 90356161
Homicide 85.81 9.35 32 234941 287 90393187
Lung diffusion test abnormal 85.32 9.35 32 234941 292 90393182
Antidepressant discontinuation syndrome 85.02 9.35 27 234946 140 90393334
Abnormal behaviour 85.02 9.35 184 234789 22444 90371030
Taste disorder 84.64 9.35 27 234946 61519 90331955
Nystagmus 82.89 9.35 98 234875 7129 90386345
Camptocormia 81.04 9.35 30 234943 263 90393211
Liver function test increased 80.81 9.35 61 234912 84794 90308680
Decorticate posture 79.81 9.35 31 234942 314 90393160
Respiratory disorder neonatal 79.54 9.35 48 234925 1353 90392121
Rheumatoid arthritis 78.36 9.35 584 234389 362030 90031444
Colitis microscopic 78.24 9.35 119 234854 11040 90382434
Neovascularisation 77.77 9.35 50 234923 1580 90391894
Pruritus 77.59 9.35 965 234008 540560 89852914
Delusion 77.14 9.35 133 234840 13707 90379767
Dyskinesia 76.97 9.35 239 234734 36295 90357179
Newborn persistent pulmonary hypertension 76.91 9.35 29 234944 269 90393205
Cardiotoxicity 76.40 9.35 119 234854 11270 90382204
Reversible cerebral vasoconstriction syndrome 75.93 9.35 72 234901 4058 90389416
Swollen tongue 75.89 9.35 277 234696 45679 90347795
Restless legs syndrome 75.77 9.35 175 234798 22295 90371179
Onychomadesis 75.29 9.35 14 234959 45984 90347490
Impulsive behaviour 75.05 9.35 50 234923 1680 90391794
Neonatal asphyxia 74.80 9.35 30 234943 333 90393141
Pyrexia 74.60 9.35 1234 233739 659251 89734223
Hot flush 74.54 9.35 329 234644 59159 90334315
Dysphonia 73.90 9.35 342 234631 62742 90330732
Rash erythematous 73.37 9.35 349 234624 64755 90328719
Clonus 72.71 9.35 82 234891 5668 90387806
Disease progression 71.10 9.35 191 234782 156424 90237050
Self-injurious ideation 70.95 9.35 62 234911 3141 90390333
Myocardial depression 70.70 9.35 34 234939 599 90392875
Somnambulism 70.68 9.35 84 234889 6144 90387330
Pneumonia aspiration 69.50 9.35 249 234724 40691 90352783
Muscle twitching 69.33 9.35 177 234796 24025 90369449
Hostility 69.31 9.35 53 234920 2220 90391254
Bipolar disorder 69.00 9.35 100 234873 8885 90384589
Physical assault 68.13 9.35 37 234936 849 90392625
Lymphocytic oesophagitis 67.98 9.35 18 234955 41 90393433
Neonatal respiratory failure 67.86 9.35 27 234946 293 90393181
Hypersensitivity 67.85 9.35 803 234170 453874 89939600
Full blood count abnormal 67.69 9.35 229 234744 36368 90357106
Hypothermia 67.13 9.35 134 234839 15441 90378033
Headache 66.73 9.35 2802 232171 859944 89533530
Malignant mediastinal neoplasm 66.71 9.35 43 234930 1365 90392109
Euphoric mood 66.47 9.35 76 234897 5333 90388141
Drug screen false positive 65.97 9.35 37 234936 906 90392568
Sepsis 65.64 9.35 242 234731 179572 90213902
Alcohol interaction 65.00 9.35 46 234927 1708 90391766
Suicidal behaviour 64.92 9.35 56 234917 2788 90390686
Platelet count decreased 64.49 9.35 164 234809 136805 90256669
Lupus-like syndrome 64.43 9.35 23 234950 48823 90344651
Accommodation disorder 64.39 9.35 28 234945 386 90393088
Breast cancer stage II 64.12 9.35 8 234965 35326 90358148
Pleurothotonus 63.81 9.35 41 234932 1294 90392180
Psychotic disorder 63.67 9.35 202 234771 31028 90362446
Somatic symptom disorder 63.28 9.35 60 234913 3381 90390093
Abdominal pain upper 63.03 9.35 555 234418 332119 90061355
Fall 62.68 9.35 1664 233309 480146 89913328
Panic reaction 62.62 9.35 69 234904 4648 90388826
Hypoglycaemia 62.44 9.35 351 234622 69497 90323977
Speech disorder 62.43 9.35 259 234714 45326 90348148
Coma scale abnormal 62.40 9.35 75 234898 5551 90387923
Adverse event 62.19 9.35 132 234841 117286 90276188
Drug tolerance decreased 61.53 9.35 6 234967 32124 90361350
Ventricular septal defect 61.48 9.35 73 234900 5334 90388140
Large for dates baby 61.39 9.35 29 234944 490 90392984
Cataplexy 61.33 9.35 42 234931 1478 90391996
Product residue present 60.87 9.35 65 234908 4226 90389248
Mood altered 60.56 9.35 136 234837 17008 90376466
Prescribed underdose 60.52 9.35 63 234910 74956 90318518
Osteoporosis 60.44 9.35 98 234875 96433 90297041
Angioedema 59.98 9.35 329 234644 64547 90328927
Emotional disorder 59.87 9.35 125 234848 14872 90378602
Homicidal ideation 59.83 9.35 44 234929 1736 90391738
Amyloid arthropathy 59.82 9.35 43 234930 1637 90391837
Neonatal seizure 59.54 9.35 30 234943 587 90392887
Contusion 59.42 9.35 394 234579 250822 90142652
Neutropenia 58.76 9.35 342 234631 224562 90168912
Hypersomnia 58.12 9.35 154 234819 21377 90372097
Inappropriate affect 57.89 9.35 35 234938 990 90392484
Neonatal hypoxia 57.53 9.35 31 234942 700 90392774
Drug use disorder 57.12 9.35 88 234885 8255 90385219
Benzodiazepine drug level increased 56.94 9.35 21 234952 182 90393292
Tinnitus 56.77 9.35 242 234731 42860 90350614
Cyanosis neonatal 56.26 9.35 26 234947 417 90393057
Libido increased 56.13 9.35 42 234931 1702 90391772
Pain in extremity 55.76 9.35 827 234146 449702 89943772
Dizziness 55.71 9.35 1957 233016 587327 89806147
Knee arthroplasty 55.38 9.35 81 234892 83101 90310373
Physical deconditioning 55.10 9.35 46 234927 2189 90391285
Depressive symptom 54.64 9.35 68 234905 5217 90388257
Anaemia 54.57 9.35 618 234355 352184 90041290
Amniotic fluid volume increased 53.96 9.35 20 234953 176 90393298
Therapeutic product effect incomplete 53.82 9.35 289 234684 193607 90199867
Cognitive disorder 53.81 9.35 336 234637 69071 90324403
Dyspnoea 53.72 9.35 1809 233164 879146 89514328
Haemangioma congenital 53.56 9.35 27 234946 529 90392945
Pyramidal tract syndrome 53.42 9.35 27 234946 532 90392942
Libido decreased 52.95 9.35 51 234922 2931 90390543
Rhabdomyolysis 52.92 9.35 268 234705 50988 90342486
Hepatic necrosis 52.90 9.35 74 234899 6364 90387110
Sciatica 52.83 9.35 115 234858 101267 90292207
Drug intolerance 52.53 9.35 830 234143 446761 89946713
Patent ductus arteriosus 52.47 9.35 62 234911 4507 90388967
Exostosis 52.14 9.35 37 234936 53097 90340377
Off label use 51.83 9.35 2334 232639 1099918 89293556
Congenital tricuspid valve incompetence 51.65 9.35 18 234955 130 90393344
Laryngitis 51.60 9.35 34 234939 50719 90342755
Drug level increased 51.59 9.35 174 234799 27588 90365886
Bruxism 51.43 9.35 60 234913 4303 90389171
Malignant neoplasm progression 51.05 9.35 127 234846 106743 90286731
Meconium in amniotic fluid 50.68 9.35 22 234951 302 90393172
Dissociation 50.50 9.35 74 234899 6641 90386833
Anorgasmia 50.43 9.35 28 234945 672 90392802
Victim of crime 49.83 9.35 30 234943 842 90392632
False positive radioisotope investigation result 49.76 9.35 11 234962 6 90393468
Diarrhoea 49.73 9.35 1962 233011 937228 89456246
Skin candida 49.62 9.35 39 234934 1702 90391772
Suspected suicide 49.51 9.35 89 234884 9479 90383995
Foot deformity 49.36 9.35 49 234924 59602 90333872
Night sweats 49.18 9.35 170 234803 128596 90264878
Self esteem decreased 49.04 9.35 29 234944 787 90392687
Asphyxia 48.74 9.35 75 234898 7028 90386446
Encephalopathy 48.06 9.35 243 234730 46201 90347273
Electrocardiogram QRS complex shortened 47.94 9.35 25 234948 527 90392947
Palpitations 47.92 9.35 554 234419 136174 90257300
Dissociative disorder 47.36 9.35 26 234947 610 90392864
Product label confusion 47.30 9.35 3 234970 22847 90370627
Logorrhoea 47.22 9.35 46 234927 2681 90390793
Inappropriate antidiuretic hormone secretion 47.16 9.35 134 234839 19371 90374103
Rapid eye movement sleep behaviour disorder 47.04 9.35 22 234951 363 90393111
Onychomycosis 46.96 9.35 19 234954 37357 90356117
Obesity 46.88 9.35 130 234843 105377 90288097
Congestive cardiomyopathy 46.79 9.35 75 234898 7279 90386195
Post-traumatic stress disorder 46.72 9.35 72 234901 6756 90386718
Torsade de pointes 46.60 9.35 114 234859 15068 90378406
Ischaemic hepatitis 46.29 9.35 46 234927 2747 90390727
Endometriosis 45.75 9.35 68 234905 6180 90387294
Panic disorder 45.63 9.35 48 234925 3067 90390407
Social avoidant behaviour 45.44 9.35 50 234923 3363 90390111
Opsoclonus myoclonus 45.24 9.35 17 234956 156 90393318
Ventricular dysfunction 45.13 9.35 52 234921 3679 90389795
Swelling face 45.05 9.35 363 234610 80989 90312485
Walking aid user 44.69 9.35 18 234955 35488 90357986
Pre-eclampsia 44.00 9.35 92 234881 10956 90382518
Dysarthria 43.65 9.35 266 234707 54216 90339258
Nervous system disorder 43.41 9.35 139 234834 21454 90372020
Lactic acidosis 43.40 9.35 251 234722 50212 90343262
Feeling of despair 42.76 9.35 47 234926 3157 90390317
Pulmonary pain 42.34 9.35 59 234914 5055 90388419
Agitation neonatal 42.15 9.35 23 234950 533 90392941
Floppy infant 42.05 9.35 15 234958 117 90393357
Loss of libido 41.96 9.35 32 234941 1335 90392139
Drug screen positive 41.53 9.35 50 234923 3707 90389767
Anticholinergic syndrome 41.49 9.35 43 234930 2700 90390774
Concussion 41.45 9.35 90 234883 11001 90382473
Frequent bowel movements 41.38 9.35 52 234921 56883 90336591
Back injury 41.29 9.35 36 234937 46586 90346888
Tonic convulsion 41.26 9.35 35 234938 1703 90391771
Paradoxical drug reaction 41.15 9.35 62 234911 5704 90387770
Finger deformity 40.88 9.35 17 234956 32880 90360594
Narcolepsy 40.84 9.35 33 234940 1499 90391975
Yawning 40.83 9.35 29 234944 1083 90392391
Tension 40.70 9.35 49 234924 3633 90389841
Transient tachypnoea of the newborn 40.67 9.35 15 234958 130 90393344
Macular degeneration 40.58 9.35 24 234949 37946 90355528
Single umbilical artery 40.49 9.35 19 234954 316 90393158
Road traffic accident 40.48 9.35 143 234830 107483 90285991
Urinary retention 40.13 9.35 199 234774 37545 90355929
VACTERL syndrome 40.06 9.35 10 234963 16 90393458
Unresponsive to stimuli 39.83 9.35 200 234773 37921 90355553
False positive investigation result 39.51 9.35 25 234948 768 90392706
Psoriasis 39.27 9.35 569 234404 147185 90246289
Slow response to stimuli 38.90 9.35 28 234945 1068 90392406
Product quality issue 38.88 9.35 93 234880 79232 90314242
Vision blurred 38.70 9.35 447 234526 109846 90283628
Congenital vesicoureteric reflux 38.64 9.35 10 234963 20 90393454
Middle insomnia 38.49 9.35 113 234860 16638 90376836
HELLP syndrome 38.49 9.35 29 234944 1188 90392286
Substance abuse 38.39 9.35 58 234915 5348 90388126
Tic 38.38 9.35 35 234938 1876 90391598
Insomnia 38.07 9.35 1133 233840 332341 90061133
Electric shock sensation 38.06 9.35 32 234941 1538 90391936
Balance disorder 37.97 9.35 402 234571 96678 90296796
Hypomania 37.69 9.35 76 234897 8821 90384653
Soft tissue injury 37.56 9.35 36 234937 2056 90391418
Anhedonia 37.42 9.35 88 234885 11343 90382131
Hallucinations, mixed 37.39 9.35 60 234913 5829 90387645
Ear infection 37.31 9.35 78 234895 69697 90323777
Medication overuse headache 37.22 9.35 31 234942 1470 90392004
Affective disorder 37.19 9.35 70 234903 7723 90385751
Neonatal respiratory distress syndrome 37.14 9.35 43 234930 3058 90390416
Emotional poverty 37.11 9.35 19 234954 385 90393089
Renal papillary necrosis 37.11 9.35 17 234956 267 90393207
Congenital hearing disorder 37.02 9.35 9 234964 12 90393462
Hospitalisation 36.62 9.35 189 234784 127911 90265563
Negative thoughts 36.61 9.35 27 234946 1070 90392404
Blood immunoglobulin E increased 36.56 9.35 51 234922 4374 90389100
Joint dislocation 36.45 9.35 37 234936 44545 90348929
Bradycardia 36.04 9.35 354 234619 83493 90309981
Anuria 36.02 9.35 102 234871 14716 90378758
Burnout syndrome 35.83 9.35 16 234957 236 90393238
Postmortem blood drug level abnormal 35.83 9.35 16 234957 236 90393238
Bipolar II disorder 35.58 9.35 19 234954 421 90393053
Rheumatoid nodule 35.55 9.35 5 234968 20161 90373313
Disability 35.43 9.35 32 234941 40713 90352761
Arthritis 35.36 9.35 271 234702 167044 90226430
Female genital tract fistula 35.12 9.35 3 234970 17865 90375609
Amenorrhoea 34.90 9.35 87 234886 11635 90381839
Joint stiffness 34.79 9.35 96 234877 77946 90315528
Stress 34.67 9.35 343 234630 81052 90312422
Therapy non-responder 34.56 9.35 210 234763 136494 90256980
Bradypnoea 34.55 9.35 51 234922 4607 90388867
Pneumocystis jirovecii pneumonia 34.49 9.35 7 234966 21609 90371865
Social anxiety disorder 34.17 9.35 21 234952 612 90392862
Hypotension 34.07 9.35 1094 233879 324303 90069171
Prescribed overdose 33.95 9.35 395 234578 97230 90296244
Tachyphrenia 33.79 9.35 31 234942 1675 90391799
Neonatal behavioural syndrome 33.71 9.35 12 234961 93 90393381
Hypoventilation neonatal 33.55 9.35 9 234964 22 90393452
Antipsychotic drug level increased 33.40 9.35 45 234928 3734 90389740
Multiple sclerosis 33.39 9.35 152 234821 27688 90365786
Incoherent 33.38 9.35 52 234921 4925 90388549
Ventricular hypokinesia 33.34 9.35 54 234919 5287 90388187
Impaired driving ability 33.25 9.35 53 234920 5120 90388354
Acute respiratory distress syndrome 33.21 9.35 155 234818 28531 90364943
Infusion site reaction 32.92 9.35 5 234968 19034 90374440
Amniorrhexis 32.83 9.35 10 234963 44 90393430
Metabolic acidosis 32.79 9.35 252 234721 55424 90338050
Feeling jittery 32.78 9.35 101 234872 15270 90378204
Electrocardiogram ST-T segment abnormal 32.76 9.35 18 234955 423 90393051
Exposure via breast milk 32.72 9.35 35 234938 2280 90391194
Hypotonia 32.14 9.35 83 234890 11343 90382131
Respiratory tract inflammation 32.03 9.35 20 234953 600 90392874
Product tampering 31.94 9.35 18 234955 445 90393029
Dropped head syndrome 31.94 9.35 15 234958 250 90393224
Adulterated product 31.83 9.35 17 234956 377 90393097
Oedema peripheral 31.66 9.35 474 234499 257441 90136033
Feelings of worthlessness 31.66 9.35 17 234956 381 90393093
Pulmonary haemorrhage neonatal 31.63 9.35 10 234963 51 90393423
Phagophobia 31.63 9.35 10 234963 51 90393423
Arrhythmia 31.61 9.35 203 234770 42129 90351345
Head injury 31.44 9.35 162 234811 31026 90362448
Cold sweat 31.42 9.35 94 234879 13987 90379487
Derealisation 31.41 9.35 28 234945 1457 90392017
Adjustment disorder with mixed anxiety and depressed mood 30.77 9.35 12 234961 123 90393351
Haemoglobin decreased 30.72 9.35 270 234703 161686 90231788
Enuresis 30.71 9.35 41 234932 3373 90390101
Increased appetite 30.59 9.35 83 234890 11682 90381792
Cerebral haematoma 30.44 9.35 46 234927 4243 90389231
Post-traumatic neck syndrome 30.35 9.35 35 234938 2479 90390995
Skin necrosis 30.34 9.35 4 234969 16937 90376537
Left ventricular hypertrophy 30.34 9.35 56 234917 6088 90387386
Dependence 30.19 9.35 32 234941 2063 90391411
Psychotic symptom 29.95 9.35 33 234940 2223 90391251
Victim of sexual abuse 29.94 9.35 20 234953 675 90392799
Renal impairment 29.87 9.35 156 234817 105265 90288209
Bradyphrenia 29.86 9.35 63 234910 7549 90385925
Persistent genital arousal disorder 29.81 9.35 20 234953 680 90392794
Brain death 29.79 9.35 44 234929 3977 90389497
Endolymphatic hydrops 29.75 9.35 6 234967 0 90393474
Pustular psoriasis 29.62 9.35 6 234967 18550 90374924
Sternal fracture 29.61 9.35 37 234936 2850 90390624
Akinesia 29.53 9.35 29 234944 1707 90391767
Frustration tolerance decreased 29.43 9.35 64 234909 7832 90385642
Hypertonia 29.34 9.35 50 234923 5105 90388369
Heart rate increased 29.29 9.35 433 234540 112469 90281005
Pancytopenia 29.23 9.35 187 234786 120076 90273398
Psychiatric symptom 29.20 9.35 60 234913 7058 90386416
Hypoaesthesia 29.15 9.35 607 234366 313603 90079871
Ulcer haemorrhage 29.04 9.35 16 234957 26305 90367169
Blood pressure increased 28.78 9.35 692 234281 196525 90196949
Eye movement disorder 28.75 9.35 55 234918 6143 90387331
Pleural effusion 28.33 9.35 172 234801 111819 90281655
Food craving 28.26 9.35 30 234943 1937 90391537
Feeling drunk 28.21 9.35 47 234926 4711 90388763
Product use issue 27.83 9.35 647 234326 329272 90064202
Cardiomyopathy 27.82 9.35 115 234858 20091 90373383
Iodine allergy 27.77 9.35 21 234952 865 90392609
Pulse abnormal 27.73 9.35 37 234936 3042 90390432
Product administration interrupted 27.50 9.35 83 234890 12409 90381065
Head discomfort 27.43 9.35 99 234874 16234 90377240
Obsessive thoughts 27.41 9.35 18 234955 590 90392884
Anaphylactic reaction 27.41 9.35 125 234848 87399 90306075
Hallucination, tactile 27.33 9.35 16 234957 426 90393048
Accidental death 27.26 9.35 30 234943 2018 90391456
Pre-existing condition improved 27.24 9.35 68 234905 9101 90384373
Blood creatine phosphokinase increased 27.18 9.35 166 234807 33857 90359617
Drug eruption 27.15 9.35 31 234942 35376 90358098
Respiratory acidosis 27.12 9.35 63 234910 8056 90385418
Congenital absence of bile ducts 27.07 9.35 8 234965 31 90393443
Illusion 27.06 9.35 24 234949 1240 90392234
Parkinsonism hyperpyrexia syndrome 27.03 9.35 13 234960 229 90393245
Chest pain 26.92 9.35 627 234346 319018 90074456
Vitamin K decreased 26.87 9.35 8 234965 32 90393442
Activation syndrome 26.83 9.35 13 234960 233 90393241
Cytokine release syndrome 26.77 9.35 20 234953 27953 90365521
Personality disorder 26.76 9.35 82 234891 12362 90381112
Encephalopathy neonatal 26.73 9.35 7 234966 15 90393459
Infantile apnoea 26.69 9.35 24 234949 1263 90392211
Autism spectrum disorder 26.60 9.35 24 234949 1269 90392205
Proctitis 26.40 9.35 4 234969 15255 90378219
Generalised anxiety disorder 26.27 9.35 34 234939 2713 90390761
Dopamine transporter scintigraphy abnormal 26.22 9.35 10 234963 96 90393378
Bundle branch block right 26.05 9.35 49 234924 5404 90388070
Infantile haemangioma 26.04 9.35 10 234963 98 90393376
Catatonia 25.97 9.35 52 234921 6004 90387470
Respiratory disorder 25.82 9.35 84 234889 64732 90328742
Maternal exposure timing unspecified 25.79 9.35 13 234960 22470 90371004
Attention deficit hyperactivity disorder 25.71 9.35 42 234931 4142 90389332
Orthostatic intolerance 25.65 9.35 24 234949 1330 90392144
Allergy to venom 25.60 9.35 6 234967 6 90393468
Colitis ulcerative 25.49 9.35 76 234897 60190 90333284
Cytomegalovirus infection 25.48 9.35 19 234954 26583 90366891
Toxic epidermal necrolysis 25.47 9.35 28 234945 32500 90360974
Foetal growth restriction 25.22 9.35 67 234906 9313 90384161
Persistent depressive disorder 25.20 9.35 23 234950 1234 90392240
Slow speech 25.19 9.35 28 234945 1905 90391569
Emotional distress 25.07 9.35 172 234801 36490 90356984
Alcoholism 25.06 9.35 27 234946 1773 90391701
Dystonia 24.97 9.35 98 234875 16721 90376753
Erythema dyschromicum perstans 24.92 9.35 9 234964 73 90393401
Fear 24.80 9.35 97 234876 16525 90376949
ECG P wave inverted 24.79 9.35 5 234968 0 90393474
Tongue biting 24.59 9.35 29 234944 2104 90391370
Neuropathy peripheral 24.39 9.35 232 234741 136738 90256736
Alcohol use 24.34 9.35 26 234947 1691 90391783
Impaired work ability 24.29 9.35 107 234866 19219 90374255
Adrenal insufficiency 24.27 9.35 25 234948 29896 90363578
Coma acidotic 24.24 9.35 10 234963 120 90393354
Helplessness 24.11 9.35 13 234960 294 90393180
Cholestasis 24.06 9.35 169 234804 36130 90357344
Blood catecholamines increased 23.94 9.35 8 234965 50 90393424
Bone marrow failure 23.86 9.35 29 234944 32192 90361282
Left ventricular dysfunction 23.86 9.35 88 234885 14581 90378893
Premature baby 23.73 9.35 128 234845 24949 90368525
Pregnancy 23.63 9.35 82 234891 61965 90331509
Ataxia 23.53 9.35 101 234872 17941 90375533
Distributive shock 23.28 9.35 36 234937 3388 90390086
Stiff person syndrome 23.19 9.35 15 234958 479 90392995
No adverse event 23.18 9.35 94 234879 67888 90325586
Neonatal respiratory distress 23.09 9.35 17 234956 672 90392802
Dysphoria 23.07 9.35 50 234923 6104 90387370
Neonatal disorder 23.04 9.35 16 234957 576 90392898
Antisocial behaviour 23.04 9.35 16 234957 576 90392898
Constipation 22.99 9.35 917 234056 279478 90113996
Blood creatinine increased 22.96 9.35 161 234812 101225 90292249
Ejection fraction decreased 22.84 9.35 131 234842 26122 90367352
Schizophreniform disorder 22.84 9.35 9 234964 95 90393379
Blood triglycerides increased 22.76 9.35 83 234890 13678 90379796
Binge eating 22.73 9.35 16 234957 589 90392885
Hyperacusis 22.63 9.35 32 234941 2779 90390695
Vasoplegia syndrome 22.61 9.35 32 234941 2782 90390692
Status epilepticus 22.60 9.35 103 234870 18771 90374703
Respiratory tract infection 22.55 9.35 78 234895 59000 90334474
Hepatic cirrhosis 22.50 9.35 86 234887 63167 90330307
Septic shock 22.48 9.35 127 234846 84033 90309441
Abnormal weight gain 22.44 9.35 31 234942 2634 90390840
Consciousness fluctuating 22.35 9.35 19 234954 927 90392547
Sleep apnoea syndrome 22.34 9.35 150 234823 31597 90361877
Claustrophobia 22.26 9.35 22 234951 1305 90392169
Sleep disorder 22.26 9.35 370 234603 197660 90195814
Depression suicidal 22.21 9.35 27 234946 2022 90391452
Incontinence 22.19 9.35 81 234892 13354 90380120
Platelet aggregation abnormal 21.99 9.35 6 234967 16 90393458
Normal newborn 21.98 9.35 17 234956 23345 90370129
Sluggishness 21.87 9.35 48 234925 5911 90387563
Bipolar I disorder 21.86 9.35 27 234946 2055 90391419
Cholestatic liver injury 21.83 9.35 37 234936 3760 90389714
Obstructive airways disorder 21.80 9.35 128 234845 25741 90367733
Neonatal hypotension 21.77 9.35 10 234963 158 90393316
Seronegative arthritis 21.74 9.35 10 234963 18224 90375250
Decreased appetite 21.74 9.35 778 234195 375762 90017712
Trunk injury 21.73 9.35 6 234967 17 90393457
Hepatocellular injury 21.70 9.35 139 234834 28819 90364655
Creatinine renal clearance decreased 21.57 9.35 11 234962 18888 90374586
Paraesthesia 21.54 9.35 823 234150 249503 90143971
Injection site reaction 21.45 9.35 145 234828 91935 90301539
Atrial fibrillation 21.43 9.35 232 234741 133379 90260095
Dyspepsia 21.38 9.35 373 234600 197787 90195687
Feeling guilty 21.31 9.35 16 234957 652 90392822
Opisthotonus 21.30 9.35 13 234960 374 90393100
Sleep talking 21.30 9.35 20 234953 1113 90392361
Pulmonary embolism 21.24 9.35 466 234507 130354 90263120
Bladder dilatation 21.19 9.35 19 234954 996 90392478
Dyssomnia 21.19 9.35 7 234966 42 90393432
Sleep paralysis 21.14 9.35 18 234955 880 90392594
Retching 21.07 9.35 102 234871 19057 90374417
Decreased immune responsiveness 21.05 9.35 60 234913 8688 90384786
Hyperbilirubinaemia neonatal 21.03 9.35 13 234960 383 90393091
Coeliac disease 20.99 9.35 192 234781 44418 90349056
Obsessive-compulsive disorder 20.93 9.35 40 234933 4464 90389010
Gangrene 20.90 9.35 4 234969 12872 90380602
Unemployment 20.86 9.35 5 234968 6 90393468
Circulatory collapse 20.84 9.35 123 234850 24781 90368693
Metabolic syndrome 20.73 9.35 25 234948 1857 90391617
Creutzfeldt-Jakob disease 20.70 9.35 10 234963 178 90393296
CYP3A4 polymorphism 20.69 9.35 8 234965 80 90393394
Colitis 20.66 9.35 102 234871 69840 90323634
Transient psychosis 20.65 9.35 7 234966 46 90393428
Hypokinesia 20.57 9.35 88 234885 15609 90377865
Abulia 20.46 9.35 16 234957 693 90392781
Forced expiratory volume decreased 20.43 9.35 46 234927 5762 90387712
Neonatal oversedation 20.43 9.35 5 234968 7 90393467
Hypercalcaemia 20.29 9.35 36 234937 34204 90359270
Therapeutic response unexpected 20.24 9.35 111 234862 21769 90371705
Poor weight gain neonatal 20.17 9.35 8 234965 86 90393388
Bursitis 20.17 9.35 231 234742 131423 90262051
Cytopenia 20.15 9.35 10 234963 17439 90376035
Miosis 19.93 9.35 62 234911 9422 90384052
Dysstasia 19.86 9.35 122 234851 24930 90368544
Muscular weakness 19.82 9.35 397 234576 206269 90187205
Adverse reaction 19.71 9.35 29 234944 29683 90363791
Musculoskeletal chest pain 19.68 9.35 117 234856 23633 90369841
Dry mouth 19.68 9.35 347 234626 183712 90209762
Hypertonia neonatal 19.66 9.35 11 234962 268 90393206
Conversion disorder 19.65 9.35 26 234947 2120 90391354
Neutrophil count decreased 19.62 9.35 107 234866 71425 90322049
White blood cell count decreased 19.52 9.35 310 234663 166799 90226675
Ventricular extrasystoles 19.50 9.35 77 234896 13173 90380301
Exposure via ingestion 19.49 9.35 29 234944 2638 90390836
Compulsive shopping 19.32 9.35 16 234957 753 90392721
Acute hepatitis B 19.31 9.35 12 234961 357 90393117
Drug abuser 19.30 9.35 29 234944 2661 90390813
Regressive behaviour 19.30 9.35 10 234963 208 90393266
Pulmonary hypoplasia 19.07 9.35 12 234961 365 90393109
Anticonvulsant drug level above therapeutic 18.98 9.35 14 234959 555 90392919
Tenosynovitis 18.97 9.35 7 234966 14560 90378914
Hyperglycaemia 18.97 9.35 209 234764 50761 90342713
Sciatic nerve neuropathy 18.92 9.35 13 234960 460 90393014
Muscle tightness 18.90 9.35 77 234896 13362 90380112
Herbal interaction 18.85 9.35 9 234964 156 90393318
Nodule 18.74 9.35 25 234948 26661 90366813
Lip and/or oral cavity cancer 18.74 9.35 17 234956 905 90392569
Intestinal strangulation 18.62 9.35 8 234965 107 90393367
Self-destructive behaviour 18.48 9.35 13 234960 478 90392996
Hypertensive heart disease 18.29 9.35 28 234945 2612 90390862
Duplicate therapy error 18.29 9.35 8 234965 112 90393362
Product monitoring error 18.28 9.35 38 234935 4506 90388968
Cartilage injury 18.27 9.35 25 234948 2106 90391368
Facial nerve disorder 18.21 9.35 14 234959 591 90392883
Persistent left superior vena cava 18.16 9.35 6 234967 36 90393438
Blood lactic acid increased 18.09 9.35 57 234916 8721 90384753
Chronic sinusitis 18.08 9.35 21 234952 23781 90369693
Cerebral vasoconstriction 18.05 9.35 19 234954 1215 90392259
Cold agglutinins positive 18.03 9.35 6 234967 37 90393437
Acquired amegakaryocytic thrombocytopenia 18.03 9.35 6 234967 37 90393437
Palmar-plantar erythrodysaesthesia syndrome 17.96 9.35 28 234945 27995 90365479
Respiratory tract congestion 17.94 9.35 27 234946 27383 90366091
Aplastic anaemia 17.93 9.35 6 234967 13263 90380211
Trismus 17.88 9.35 39 234934 4782 90388692
Congenital multiplex arthrogryposis 17.84 9.35 7 234966 73 90393401
Neurodegenerative disorder 17.83 9.35 12 234961 410 90393064
Impulse-control disorder 17.82 9.35 17 234956 965 90392509
Adverse drug reaction 17.78 9.35 205 234768 116496 90276978
Photophobia 17.77 9.35 105 234868 21164 90372310
Nausea 17.73 9.35 3202 231771 1107114 89286360
Long QT syndrome 17.72 9.35 35 234938 4002 90389472
Premature separation of placenta 17.72 9.35 26 234947 2336 90391138
Polyarthritis 17.71 9.35 13 234960 18337 90375137
Intestinal ischaemia 17.69 9.35 57 234916 8826 90384648
Cystic lymphangioma 17.65 9.35 5 234968 16 90393458
Congenital pulmonary hypertension 17.61 9.35 8 234965 123 90393351
Peak expiratory flow rate decreased 17.48 9.35 14 234959 628 90392846
Cushingoid 17.37 9.35 3 234970 10392 90383082
Neurotoxicity 17.34 9.35 18 234955 21449 90372025
Hereditary non-polyposis colorectal cancer syndrome 17.33 9.35 8 234965 128 90393346
Epstein-Barr virus infection 17.25 9.35 3 234970 10341 90383133
Skin ulcer 17.22 9.35 69 234904 50006 90343468
Hepatic cytolysis 17.14 9.35 138 234835 30778 90362696
Lethargy 17.10 9.35 244 234729 62895 90330579
Loose tooth 17.10 9.35 33 234940 3710 90389764
Ventricular fibrillation 17.08 9.35 77 234896 13967 90379507
Atypical fibroxanthoma 17.07 9.35 4 234969 4 90393470
Mucosal inflammation 17.04 9.35 84 234889 57541 90335933
Impatience 17.02 9.35 12 234961 443 90393031
Asthma 16.94 9.35 779 234194 241381 90152093
Plasma cell myeloma 16.90 9.35 52 234921 40776 90352698
Injection site pain 16.85 9.35 333 234640 173366 90220108
Parasomnia 16.84 9.35 14 234959 662 90392812
Splenic infarction 16.81 9.35 24 234949 2103 90391371
Persecutory delusion 16.80 9.35 30 234943 3178 90390296
Nephropathy toxic 16.69 9.35 6 234967 12682 90380792
Hyperinsulinaemia 16.68 9.35 8 234965 140 90393334
Neurodermatitis 16.68 9.35 29 234944 3009 90390465
Retinal detachment 16.62 9.35 47 234926 6775 90386699
Myositis 16.55 9.35 23 234950 24105 90369369
Psychomotor skills impaired 16.53 9.35 28 234945 2844 90390630
Radius fracture 16.48 9.35 34 234939 4010 90389464
Nasal polyps 16.40 9.35 4 234969 10876 90382598
Therapeutic response decreased 16.39 9.35 151 234822 89578 90303896
Haemodynamic instability 16.31 9.35 67 234906 11672 90381802
Wrong patient received product 16.30 9.35 31 234942 3446 90390028
Purging 16.27 9.35 6 234967 52 90393422
Glassy eyes 16.26 9.35 7 234966 94 90393380
Neonatal tachypnoea 16.23 9.35 8 234965 149 90393325
Starvation ketoacidosis 16.21 9.35 9 234964 216 90393258
Amnesia 16.21 9.35 382 234591 108123 90285351
Device difficult to use 16.17 9.35 13 234960 17512 90375962
Alcohol abuse 16.16 9.35 23 234950 2010 90391464
Ligament pain 16.14 9.35 9 234964 218 90393256
Eosinophilic pustular folliculitis 16.13 9.35 7 234966 96 90393378
Condition aggravated 16.13 9.35 1327 233646 594218 89799256
Congenital uterine anomaly 16.09 9.35 8 234965 152 90393322
Myalgia 16.08 9.35 580 234393 174545 90218929
Bladder trabeculation 16.07 9.35 6 234967 54 90393420
Poor personal hygiene 15.99 9.35 11 234962 390 90393084
Violence-related symptom 15.95 9.35 13 234960 598 90392876
Kleptomania 15.89 9.35 5 234968 25 90393449
Exposure via transplant 15.89 9.35 5 234968 25 90393449
Tremor neonatal 15.81 9.35 8 234965 158 90393316
Movement disorder 15.80 9.35 129 234844 28890 90364584
Rib fracture 15.76 9.35 120 234853 26315 90367159
Body temperature abnormal 15.73 9.35 26 234947 2589 90390885
Cerebral infarction 15.72 9.35 28 234945 26568 90366906
Abnormal sleep-related event 15.66 9.35 15 234958 856 90392618
Right ventricular failure 15.63 9.35 16 234957 19189 90374285
Decreased interest 15.61 9.35 35 234938 4372 90389102
Cogwheel rigidity 15.57 9.35 23 234950 2079 90391395
Central nervous system necrosis 15.54 9.35 8 234965 164 90393310
Spontaneous haematoma 15.48 9.35 17 234956 1141 90392333
Housebound 15.46 9.35 9 234964 237 90393237
Foetal alcohol syndrome 15.43 9.35 5 234968 28 90393446
Merycism 15.41 9.35 10 234963 321 90393153
Vitamin B12 decreased 15.38 9.35 39 234934 5271 90388203
Brief psychotic disorder with marked stressors 15.34 9.35 6 234967 62 90393412
Multiple sclerosis relapse 15.33 9.35 205 234768 52100 90341374
Herpes zoster 15.31 9.35 164 234809 94480 90298994
Second primary malignancy 15.28 9.35 4 234969 10374 90383100
Underdose 15.26 9.35 80 234893 53937 90339537
Vertebral lesion 15.23 9.35 14 234959 758 90392716
Poor quality sleep 15.23 9.35 113 234860 24580 90368894
Somnolence neonatal 15.11 9.35 7 234966 113 90393361
Ideas of reference 15.11 9.35 7 234966 113 90393361
Respiratory distress 15.09 9.35 161 234812 38785 90354689
Barotrauma 15.08 9.35 8 234965 175 90393299
Ascites 15.05 9.35 68 234905 47672 90345802
Drug withdrawal convulsions 15.03 9.35 19 234954 1481 90391993
Transfusion 14.89 9.35 14 234959 17474 90376000
Apallic syndrome 14.87 9.35 14 234959 782 90392692
Anal atresia 14.85 9.35 11 234962 439 90393035
Divorced 14.85 9.35 4 234969 10 90393464
Acute myeloid leukaemia 14.84 9.35 19 234954 20621 90372853
Gun shot wound 14.73 9.35 7 234966 120 90393354
Product formulation issue 14.69 9.35 13 234960 670 90392804
General symptom 14.67 9.35 10 234963 14658 90378816
Neurological symptom 14.61 9.35 45 234928 6802 90386672
Troponin abnormal 14.47 9.35 6 234967 73 90393401
Cardiac valve disease 14.43 9.35 35 234938 4600 90388874
Breast cyst 14.43 9.35 22 234951 2045 90391429
Flight of ideas 14.42 9.35 11 234962 459 90393015
Radiculopathy 14.41 9.35 16 234957 18489 90374985
Basilar artery occlusion 14.41 9.35 8 234965 192 90393282
Gambling disorder 14.40 9.35 17 234956 1235 90392239
Lung diffusion test decreased 14.36 9.35 14 234959 817 90392657
Tympanic membrane disorder 14.33 9.35 8 234965 194 90393280
Influenza like illness 14.33 9.35 291 234682 80320 90313154
Pancreatic enlargement 14.32 9.35 6 234967 75 90393399
Marital problem 14.30 9.35 8 234965 195 90393279
Injection site erythema 14.25 9.35 175 234798 98327 90295147
Ulcer 14.24 9.35 41 234932 32841 90360633
Self-medication 14.23 9.35 28 234945 3192 90390282
Breech presentation 14.23 9.35 17 234956 1250 90392224
Drug hypersensitivity 14.21 9.35 1391 233582 462218 89931256
Laboratory test abnormal 14.19 9.35 58 234915 41796 90351678
Postmortem blood drug level increased 14.17 9.35 13 234960 702 90392772
Language disorder 14.15 9.35 25 234948 2627 90390847
Drug level above therapeutic 14.13 9.35 40 234933 5769 90387705
Anal incontinence 14.13 9.35 81 234892 16149 90377325
Haemangioma 14.12 9.35 27 234946 3015 90390459
Vertebral artery occlusion 14.12 9.35 8 234965 200 90393274
Neurological examination abnormal 14.11 9.35 10 234963 372 90393102
Disturbance in sexual arousal 14.04 9.35 9 234964 283 90393191
Psychiatric decompensation 14.02 9.35 21 234952 1922 90391552
Respiration abnormal 14.00 9.35 49 234924 7914 90385560
Deja vu 13.98 9.35 7 234966 135 90393339
Perinatal depression 13.96 9.35 14 234959 845 90392629
Bile acid malabsorption 13.95 9.35 9 234964 286 90393188
Pupil fixed 13.95 9.35 22 234951 2106 90391368
Electroencephalogram abnormal 13.92 9.35 32 234941 4064 90389410
Toxicologic test abnormal 13.91 9.35 13 234960 719 90392755
Female sexual dysfunction 13.91 9.35 6 234967 81 90393393
Vaginal discharge 13.91 9.35 18 234955 19446 90374028
Feeling of body temperature change 13.84 9.35 39 234934 5610 90387864
Drug specific antibody 13.82 9.35 24 234949 2488 90390986
Foetal arrhythmia 13.80 9.35 8 234965 209 90393265
Jaundice neonatal 13.80 9.35 15 234958 995 90392479
Depersonalisation/derealisation disorder 13.77 9.35 19 234954 1613 90391861
Personality change 13.70 9.35 46 234927 7275 90386199
Formication 13.68 9.35 35 234938 4756 90388718
Coarctation of the aorta 13.66 9.35 12 234961 612 90392862
Neoplasm progression 13.65 9.35 64 234909 44422 90349052
Migraine 13.64 9.35 614 234359 189778 90203696
Hypersexuality 13.63 9.35 12 234961 614 90392860
Right ventricular systolic pressure decreased 13.59 9.35 5 234968 43 90393431
Premature delivery 13.59 9.35 53 234920 38709 90354765
Muscle tone disorder 13.58 9.35 7 234966 144 90393330
Focal dyscognitive seizures 13.49 9.35 27 234946 3117 90390357
Basal cell carcinoma 13.48 9.35 43 234930 33346 90360128
Tumour lysis syndrome 13.48 9.35 6 234967 11146 90382328
Eye pruritus 13.47 9.35 35 234938 28992 90364482
Staring 13.43 9.35 19 234954 1651 90391823
Respiratory rate decreased 13.40 9.35 31 234942 3952 90389522
Hypertriglyceridaemia 13.40 9.35 48 234925 7841 90385633
Substance use disorder 13.40 9.35 21 234952 1999 90391475
Pulmonary vein occlusion 13.34 9.35 6 234967 90 90393384
Talipes 13.34 9.35 19 234954 1661 90391813
Humidity intolerance 13.26 9.35 10 234963 410 90393064
Hyperemesis gravidarum 13.24 9.35 13 234960 765 90392709
Metastases to bone 13.23 9.35 29 234944 25476 90367998
Defect conduction intraventricular 13.18 9.35 8 234965 228 90393246
Snoring 13.17 9.35 36 234937 5090 90388384
Polydactyly 13.16 9.35 9 234964 316 90393158
Rash pruritic 13.08 9.35 143 234830 82071 90311403
Flat affect 13.08 9.35 19 234954 1692 90391782
Atrophic vulvovaginitis 13.05 9.35 20 234953 1867 90391607
Multiple allergies 13.04 9.35 12 234961 15134 90378340
Device expulsion 13.03 9.35 58 234915 40828 90352646
Microcephaly 13.03 9.35 17 234956 1367 90392107
Sinus rhythm 13.01 9.35 17 234956 1369 90392105
Left ventricle outflow tract obstruction 13.01 9.35 10 234963 422 90393052
Brain contusion 13.01 9.35 12 234961 653 90392821
Parachute mitral valve 12.88 9.35 6 234967 98 90393376
Alcohol poisoning 12.86 9.35 20 234953 1892 90391582
Product prescribing error 12.82 9.35 127 234846 30018 90363456
Obsessive rumination 12.80 9.35 3 234970 3 90393471
Antidepressant drug level decreased 12.80 9.35 3 234970 3 90393471
Sleep disorder due to a general medical condition 12.78 9.35 66 234907 44672 90348802
Communication disorder 12.78 9.35 27 234946 3239 90390235
Confusional state 12.76 9.35 1165 233808 385040 90008434
Procedural pain 12.76 9.35 44 234929 33316 90360158
Delusional disorder, unspecified type 12.73 9.35 10 234963 436 90393038
Labour complication 12.72 9.35 7 234966 165 90393309
Developmental hip dysplasia 12.70 9.35 18 234955 1567 90391907
Gastrointestinal injury 12.61 9.35 13 234960 811 90392663
Femur fracture 12.60 9.35 69 234904 46013 90347461
Lactation disorder 12.57 9.35 10 234963 444 90393030
Ultrasound abdomen abnormal 12.51 9.35 5 234968 55 90393419
Spondylitis 12.49 9.35 11 234962 14167 90379307
Carotid artery thrombosis 12.48 9.35 4 234969 9088 90384386
Ankle fracture 12.44 9.35 93 234880 20277 90373197
Hyporesponsive to stimuli 12.42 9.35 18 234955 1599 90391875
Rabies 12.40 9.35 4 234969 22 90393452
Transplant rejection 12.36 9.35 9 234964 12749 90380725
Myelodysplastic syndrome 12.36 9.35 22 234951 20881 90372593
Colitis ischaemic 12.35 9.35 64 234909 12282 90381192
Graft versus host disease 12.26 9.35 3 234970 8141 90385333
Adrenergic syndrome 12.26 9.35 6 234967 110 90393364
Parkinsonian gait 12.20 9.35 11 234962 581 90392893
Pathogen resistance 12.20 9.35 3 234970 8112 90385362
Tongue discomfort 12.17 9.35 24 234949 2741 90390733
Ligament sprain 12.15 9.35 72 234901 14527 90378947
Morbihan disease 12.11 9.35 4 234969 24 90393450
Dermatillomania 12.11 9.35 8 234965 265 90393209
Angle closure glaucoma 12.11 9.35 24 234949 2751 90390723
Prescription form tampering 12.10 9.35 12 234961 715 90392759
Congenital naevus 12.07 9.35 7 234966 183 90393291
Maternal drugs affecting foetus 12.06 9.35 35 234938 5120 90388354
Fear-related avoidance of activities 12.04 9.35 7 234966 184 90393290
Upper gastrointestinal haemorrhage 12.02 9.35 26 234947 22950 90370524
Mechanical urticaria 12.01 9.35 11 234962 593 90392881
Third stage postpartum haemorrhage 11.97 9.35 4 234969 25 90393449
Blood bilirubin increased 11.94 9.35 65 234908 43405 90350069
Anterograde amnesia 11.93 9.35 11 234962 598 90392876
Affect lability 11.91 9.35 84 234889 17979 90375495
Nonspecific reaction 11.90 9.35 24 234949 2785 90390689
Paroxysmal perceptual alteration 11.90 9.35 5 234968 63 90393411
Pleural rub 11.90 9.35 5 234968 63 90393411
Product use in unapproved indication 11.90 9.35 732 234241 335504 90057970
Hypertrophic cardiomyopathy 11.88 9.35 21 234952 2207 90391267
Gastrointestinal haemorrhage 11.71 9.35 164 234809 90084 90303390
Hereditary ataxia 11.71 9.35 4 234969 27 90393447
Restless arm syndrome 11.63 9.35 5 234968 67 90393407
Anxiety disorder due to a general medical condition 11.59 9.35 3 234970 6 90393468
Platelet aggregation decreased 11.59 9.35 4 234969 28 90393446
Hypokinetic dysarthria 11.59 9.35 4 234969 28 90393446
Hypernatriuria 11.59 9.35 4 234969 28 90393446
Heavy menstrual bleeding 11.57 9.35 92 234881 20438 90373036
Maternal exposure during breast feeding 11.57 9.35 39 234934 6181 90387293
Neuropsychiatric syndrome 11.49 9.35 5 234968 69 90393405
Hyperlipidaemia 11.48 9.35 100 234873 22816 90370658
Dreamy state 11.47 9.35 4 234969 29 90393445
Electrocardiogram abnormal 11.45 9.35 55 234918 10243 90383231
Hypnopompic hallucination 11.43 9.35 5 234968 70 90393404
Blood calcium decreased 11.41 9.35 40 234933 30142 90363332
Chorea 11.40 9.35 20 234953 2090 90391384
Alcohol withdrawal syndrome 11.38 9.35 13 234960 911 90392563
Breast reconstruction 11.35 9.35 8 234965 295 90393179
Menopause 11.34 9.35 26 234947 3295 90390179
Attention-seeking behaviour 11.30 9.35 5 234968 72 90393402
Bradykinesia 11.28 9.35 41 234932 6747 90386727
Hepatitis 11.27 9.35 123 234850 70616 90322858
Amphetamines positive 11.24 9.35 7 234966 209 90393265
Body mass index decreased 11.22 9.35 10 234963 520 90392954
Mutism 11.20 9.35 18 234955 1751 90391723
Skin maceration 11.18 9.35 7 234966 211 90393263
Xanthopsia 11.18 9.35 7 234966 211 90393263
Waxy flexibility 11.15 9.35 6 234967 135 90393339
Skin disorder 11.15 9.35 53 234920 36653 90356821
Meningism 11.14 9.35 10 234963 525 90392949
Arachnoid cyst 11.12 9.35 8 234965 305 90393169
Anxiety disorder 11.12 9.35 33 234940 4889 90388585
Alpha 2 globulin increased 11.11 9.35 6 234967 136 90393338
Patella fracture 11.10 9.35 22 234951 2521 90390953
Bronchopulmonary aspergillosis 11.10 9.35 8 234965 11390 90382084
Junctional ectopic tachycardia 11.09 9.35 7 234966 214 90393260
Placental disorder 11.04 9.35 17 234956 1594 90391880
CYP2D6 polymorphism 11.00 9.35 5 234968 77 90393397
Poor feeding infant 10.94 9.35 10 234963 538 90392936
Foetal heart rate deceleration abnormality 10.92 9.35 11 234962 668 90392806
Sinus disorder 10.90 9.35 49 234924 34398 90359076
Intellectual disability 10.89 9.35 15 234958 1271 90392203
Mixed anxiety and depressive disorder 10.86 9.35 9 234964 424 90393050
Asthenia 10.81 9.35 1215 233758 532536 89860938
Intervertebral disc protrusion 10.81 9.35 113 234860 27083 90366391
Poverty of speech 10.78 9.35 8 234965 320 90393154
Palate injury 10.77 9.35 5 234968 81 90393393
Hypoglycaemic seizure 10.75 9.35 10 234963 550 90392924
Hypocalcaemia 10.75 9.35 65 234908 42303 90351171
Hyperkalaemia 10.74 9.35 112 234861 64852 90328622
Subacute kidney injury 10.74 9.35 3 234970 9 90393465
Crush injury 10.74 9.35 3 234970 9 90393465
Dysaesthesia 10.72 9.35 34 234939 5221 90388253
Bilirubin conjugated abnormal 10.66 9.35 5 234968 83 90393391
Therapeutic response changed 10.62 9.35 15 234958 1302 90392172
Subendocardial ischaemia 10.61 9.35 5 234968 84 90393390
Developmental coordination disorder 10.52 9.35 4 234969 38 90393436
Dissociative amnesia 10.52 9.35 4 234969 38 90393436
Hemiplegia 10.50 9.35 16 234957 16144 90377330
Gastric bypass 10.49 9.35 19 234954 2035 90391439
Pleural disorder 10.43 9.35 11 234962 705 90392769
Tooth loss 10.40 9.35 43 234930 7511 90385963
Intestinal anastomosis complication 10.40 9.35 8 234965 338 90393136
Leukopenia 10.40 9.35 191 234782 100519 90292955
Hypnagogic hallucination 10.38 9.35 7 234966 240 90393234
Sudden onset of sleep 10.38 9.35 10 234963 575 90392899
Sensory disturbance 10.35 9.35 72 234901 15341 90378133
Postural orthostatic tachycardia syndrome 10.34 9.35 20 234953 2252 90391222
Foaming at mouth 10.33 9.35 15 234958 1335 90392139
Oral candidiasis 10.30 9.35 52 234921 35403 90358071
Pulmonary artery stenosis congenital 10.30 9.35 9 234964 456 90393018
Phlebolith 10.28 9.35 7 234966 244 90393230
Bacteraemia 10.26 9.35 27 234946 22273 90371201
Bone marrow leukaemic cell infiltration 10.26 9.35 4 234969 41 90393433
Death 10.21 9.35 1032 233941 455519 89937955
Anaemia of pregnancy 10.21 9.35 6 234967 161 90393313
Tanning 10.20 9.35 5 234968 92 90393382
Substance use 10.18 9.35 14 234959 1185 90392289
Skin texture abnormal 10.18 9.35 10 234963 589 90392885
Dysuria 10.17 9.35 151 234822 39250 90354224
Portal fibrosis 10.16 9.35 8 234965 350 90393124
Haemangioma of liver 10.16 9.35 15 234958 1355 90392119
Pericardial effusion 10.15 9.35 55 234918 36778 90356696
Vasoconstriction 10.15 9.35 12 234961 873 90392601
Chest discomfort 10.13 9.35 277 234696 138088 90255386
Hyperchloraemia 10.11 9.35 12 234961 876 90392598
Conduction disorder 10.10 9.35 17 234956 1718 90391756
Gastrointestinal toxicity 10.09 9.35 6 234967 9461 90384013
Enthesopathy 9.97 9.35 6 234967 9398 90384076
Polycythaemia 9.96 9.35 14 234959 1209 90392265
Urine analysis abnormal 9.94 9.35 33 234940 5188 90388286
Congenital melanocytic naevus 9.89 9.35 3 234970 13 90393461
Osteoporosis postmenopausal 9.87 9.35 8 234965 365 90393109
Stupor 9.87 9.35 34 234939 5448 90388026
Human chorionic gonadotropin positive 9.85 9.35 4 234969 46 90393428
Orgasm abnormal 9.83 9.35 5 234968 100 90393374
Hyperventilation 9.82 9.35 39 234934 6689 90386785
Hepatic function abnormal 9.76 9.35 75 234898 46213 90347261
Gallbladder disorder 9.71 9.35 86 234887 19717 90373757
Eyelid contusion 9.69 9.35 5 234968 103 90393371
Hidradenitis 9.68 9.35 29 234944 4318 90389156
Inadequate analgesia 9.67 9.35 24 234949 3200 90390274
Parkinson's disease 9.67 9.35 13 234960 1077 90392397
Fear of injection 9.65 9.35 5 234968 8510 90384964
Gastric banding 9.65 9.35 5 234968 104 90393370
Bronchospasm 9.58 9.35 25 234948 20684 90372790
Pseudophaeochromocytoma 9.56 9.35 5 234968 106 90393368
Femoral neck fracture 9.53 9.35 52 234921 10181 90383293
Foramen magnum stenosis 9.52 9.35 6 234967 183 90393291
Pulseless electrical activity 9.43 9.35 47 234926 8885 90384589
Fractured coccyx 9.41 9.35 14 234959 1273 90392201
Postictal paralysis 9.39 9.35 7 234966 282 90393192
Cerebellar haematoma 9.38 9.35 8 234965 392 90393082
Cataract 9.36 9.35 131 234842 71961 90321513
Adrenal cyst 9.36 9.35 5 234968 111 90393363
Erythema induratum 9.35 9.35 6 234967 189 90393285

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 1148.07 11.20 711 92506 25134 42502984
Completed suicide 1081.31 11.20 1188 92029 95277 42432841
Suicide attempt 699.58 11.20 669 92548 45431 42482687
Toxicity to various agents 691.33 11.20 1536 91681 227600 42300518
Intentional overdose 657.45 11.20 680 92537 50776 42477342
Suicidal ideation 621.65 11.20 640 92577 47521 42480597
Drug withdrawal syndrome 522.61 11.20 409 92808 21140 42506978
Foetal exposure during pregnancy 458.37 11.20 541 92676 46770 42481348
Overdose 401.19 11.20 778 92439 104486 42423632
Hyperhidrosis 352.18 11.20 675 92542 89837 42438281
Coma 340.68 11.20 498 92719 53056 42475062
Sedation 302.54 11.20 353 92864 30122 42497996
Drug abuse 296.49 11.20 686 92531 104085 42424033
Withdrawal syndrome 283.87 11.20 245 92972 14530 42513588
Respiratory disorder neonatal 280.28 11.20 119 93098 1851 42526267
Nightmare 263.88 11.20 299 92918 24713 42503405
Drug withdrawal syndrome neonatal 229.53 11.20 135 93082 4326 42523792
Poisoning deliberate 225.62 11.20 183 93034 9951 42518167
Drug interaction 212.99 11.20 1147 92070 265852 42262266
Febrile neutropenia 211.93 11.20 71 93146 185632 42342486
Anxiety 194.69 11.20 636 92581 117924 42410194
Agitation 191.61 11.20 430 92787 63884 42464234
Intentional self-injury 181.58 11.20 194 93023 15008 42513110
Depression 177.99 11.20 592 92625 110771 42417347
Disturbance in attention 174.46 11.20 267 92950 29599 42498519
Pyrexia 164.59 11.20 389 92828 393653 42134465
Maternal exposure during pregnancy 163.82 11.20 130 93087 6848 42521270
Sopor 160.37 11.20 170 93047 13032 42515086
Mania 159.64 11.20 153 93064 10394 42517724
Pneumonia 157.69 11.20 441 92776 421708 42106410
Mydriasis 157.54 11.20 140 93077 8630 42519488
Inspiratory capacity decreased 155.83 11.20 91 93126 2876 42525242
Depressed mood 146.47 11.20 216 93001 23168 42504950
Anaemia 145.89 11.20 243 92974 280035 42248083
Major depression 145.14 11.20 109 93108 5289 42522829
Atrial septal defect 141.42 11.20 126 93091 7793 42520325
Myoclonus 139.06 11.20 179 93038 16886 42511232
Small for dates baby 136.47 11.20 104 93113 5159 42522959
Exposure during pregnancy 135.08 11.20 127 93090 8421 42519697
Disease progression 133.50 11.20 74 93143 143582 42384536
Neutropenia 131.94 11.20 145 93072 199286 42328832
Electrocardiogram QT prolonged 131.11 11.20 310 92907 47635 42480483
Sepsis 118.02 11.20 158 93059 199176 42328942
Drug dependence 116.68 11.20 220 92997 28874 42499244
Hyperreflexia 115.57 11.20 81 93136 3526 42524592
Rash 111.02 11.20 279 92938 276675 42251443
Hallucination, auditory 108.90 11.20 148 93069 14716 42513402
Selective eating disorder 108.53 11.20 60 93157 1704 42526414
Erectile dysfunction 108.23 11.20 195 93022 24718 42503400
Bipolar disorder 107.23 11.20 80 93137 3842 42524276
Restlessness 106.10 11.20 212 93005 29037 42499081
Cataplexy 103.77 11.20 38 93179 389 42527729
Tremor 101.77 11.20 451 92766 96478 42431640
Seizure 101.29 11.20 526 92691 120035 42408083
Poisoning 101.15 11.20 142 93075 14557 42513561
Hypotonia neonatal 101.09 11.20 54 93163 1430 42526688
Nephrolithiasis 100.53 11.20 238 92979 36592 42491526
Hallucination, visual 99.69 11.20 171 93046 20849 42507269
Dyspnoea 99.16 11.20 566 92651 442055 42086063
Somnolence 97.51 11.20 584 92633 140521 42387597
Bradycardia neonatal 94.50 11.20 50 93167 1298 42526820
Psychotic disorder 91.10 11.20 199 93018 29009 42499109
Neonatal respiratory distress syndrome 89.03 11.20 76 93141 4437 42523681
Diarrhoea 86.00 11.20 623 92594 460226 42067892
Malignant neoplasm progression 85.57 11.20 67 93150 108333 42419785
Sexual dysfunction 83.62 11.20 88 93129 6687 42521431
Irritability 83.62 11.20 188 93029 27940 42500178
Platelet count decreased 79.79 11.20 112 93105 138469 42389649
Aggression 79.75 11.20 245 92972 43918 42484200
Infantile apnoea 79.25 11.20 42 93175 1094 42527024
Pruritus 78.83 11.20 186 93031 188585 42339533
Neuroleptic malignant syndrome 78.31 11.20 156 93061 21316 42506802
Agitation neonatal 78.18 11.20 45 93172 1383 42526735
Delusion 78.08 11.20 126 93091 14608 42513510
Dyskinesia 78.06 11.20 172 93045 25218 42502900
Thrombocytopenia 76.68 11.20 191 93026 190088 42338030
Talipes 75.83 11.20 52 93165 2184 42525934
Tachycardia 72.11 11.20 422 92795 100665 42427453
Cytokine release syndrome 72.00 11.20 7 93210 44520 42483598
Hypomania 70.45 11.20 52 93165 2456 42525662
Psychotic symptom 70.41 11.20 51 93166 2339 42525779
Miosis 69.91 11.20 114 93103 13332 42514786
Psychomotor hyperactivity 69.73 11.20 102 93115 10856 42517262
Hypertonia 69.05 11.20 69 93148 4932 42523186
Off label use 68.81 11.20 984 92233 637351 41890767
Infection 67.09 11.20 88 93129 111980 42416138
Feelings of worthlessness 64.80 11.20 25 93192 299 42527819
Cough 64.79 11.20 188 93029 177915 42350203
Septic shock 64.67 11.20 63 93154 91609 42436509
Panic attack 62.03 11.20 97 93120 10948 42517170
Anger 61.84 11.20 106 93111 12912 42515206
Akathisia 61.80 11.20 94 93123 10357 42517761
Renal impairment 61.54 11.20 91 93126 110137 42417981
Antipsychotic drug level above therapeutic 61.21 11.20 37 93180 1247 42526871
Physical deconditioning 61.20 11.20 47 93170 2358 42525760
Pulmonary artery stenosis 61.18 11.20 24 93193 301 42527817
Insomnia 60.30 11.20 454 92763 117799 42410319
Pancytopenia 60.26 11.20 103 93114 117640 42410478
Muscle rigidity 59.68 11.20 100 93117 11959 42516159
Stress cardiomyopathy 59.27 11.20 49 93168 2736 42525382
Myelosuppression 58.96 11.20 9 93208 40452 42487666
Generalised tonic-clonic seizure 58.93 11.20 158 93059 26221 42501897
Social anxiety disorder 58.74 11.20 28 93189 578 42527540
Homicide 58.71 11.20 32 93185 883 42527235
Erythema 58.63 11.20 92 93125 108701 42419417
Somnambulism 58.34 11.20 53 93164 3362 42524756
Cytomegalovirus infection 58.20 11.20 3 93214 32303 42495815
Acute kidney injury 58.06 11.20 519 92698 366818 42161300
Neuropathy peripheral 57.92 11.20 83 93134 101770 42426348
Restless legs syndrome 57.60 11.20 87 93130 9527 42518591
Floppy infant 57.60 11.20 19 93198 138 42527980
Intentional product misuse 57.52 11.20 278 92939 61622 42466496
Parkinsonism 56.50 11.20 91 93126 10532 42517586
Clonus 55.04 11.20 52 93165 3468 42524650
Antidepressant drug level increased 53.99 11.20 20 93197 212 42527906
Altered state of consciousness 53.45 11.20 163 93054 29096 42499022
Hypertonia neonatal 52.55 11.20 26 93191 584 42527534
Extrapyramidal disorder 52.52 11.20 113 93104 16299 42511819
Abulia 52.39 11.20 27 93190 663 42527455
Confusional state 52.03 11.20 578 92639 167019 42361099
Developmental delay 51.66 11.20 48 93169 3134 42524984
Antidepressant discontinuation syndrome 51 11.20 11 93206 7 42528111
Persecutory delusion 50.73 11.20 50 93167 3514 42524604
Hypospadias 50.70 11.20 50 93167 3517 42524601
Death 50.38 11.20 727 92490 470458 42057660
Apathy 50.26 11.20 76 93141 8330 42519788
Congenital megaureter 50.00 11.20 17 93200 137 42527981
Drug screen positive 49.81 11.20 53 93164 4078 42524040
Electric shock sensation 48.69 11.20 23 93194 465 42527653
Impulsive behaviour 48.16 11.20 41 93176 2384 42525734
Dissociation 48.07 11.20 50 93167 3748 42524370
Haemoglobin decreased 48.03 11.20 140 93077 132331 42395787
Tardive dyskinesia 47.80 11.20 67 93150 6857 42521261
Maternal drugs affecting foetus 47.62 11.20 50 93167 3789 42524329
Oedema peripheral 47.05 11.20 147 93070 135929 42392189
Urinary retention 46.99 11.20 200 93017 42014 42486104
Blood creatinine increased 46.99 11.20 107 93110 109896 42418222
Cardio-respiratory arrest 46.55 11.20 252 92965 58384 42469734
Metabolic acidosis 46.10 11.20 230 92987 51628 42476490
Neonatal hypoxia 45.68 11.20 23 93194 537 42527581
Libido decreased 43.94 11.20 55 93162 5043 42523075
Feeling abnormal 43.84 11.20 282 92935 69504 42458614
Stomatitis 43.78 11.20 28 93189 50301 42477817
Product used for unknown indication 43.28 11.20 29 93188 1172 42526946
Respiratory failure 43.18 11.20 140 93077 127992 42400126
COVID-19 43.15 11.20 121 93096 115827 42412291
Multiple organ dysfunction syndrome 42.57 11.20 93 93124 96942 42431176
Rheumatoid arthritis 42.15 11.20 20 93197 42420 42485698
Accidental death 41.58 11.20 42 93175 3041 42525077
Postmortem blood drug level increased 41.34 11.20 21 93196 500 42527618
Reduced facial expression 41.31 11.20 31 93186 1502 42526616
Feeling jittery 41.14 11.20 50 93167 4448 42523670
Interstitial lung disease 40.72 11.20 68 93149 78394 42449724
Salivary hypersecretion 40.49 11.20 80 93137 10863 42517255
Cyanosis neonatal 40.41 11.20 18 93199 316 42527802
Congenital nystagmus 40.32 11.20 13 93204 87 42528031
Pleural effusion 40.30 11.20 96 93121 97070 42431048
Eosinophilic pleural effusion 40.16 11.20 18 93199 321 42527797
Paroxysmal perceptual alteration 39.86 11.20 16 93201 214 42527904
Alcoholism 39.67 11.20 40 93177 2890 42525228
Non-cardiogenic pulmonary oedema 39.64 11.20 25 93192 910 42527208
Infantile vomiting 39.58 11.20 13 93204 93 42528025
Arthralgia 39.30 11.20 275 92942 204963 42323155
Infusion related reaction 39.27 11.20 45 93172 60761 42467357
Abnormal behaviour 38.99 11.20 137 93080 26314 42501804
Drug use disorder 38.79 11.20 76 93141 10257 42517861
Memory impairment 38.63 11.20 214 93003 50008 42478110
Premature baby 38.62 11.20 125 93092 23028 42505090
Hyperthermia 38.44 11.20 85 93132 12489 42515629
Sleep apnoea syndrome 38.18 11.20 119 93098 21489 42506629
Self-injurious ideation 37.96 11.20 32 93185 1836 42526282
Gastrointestinal haemorrhage 37.85 11.20 100 93117 97626 42430492
Oscillopsia 37.79 11.20 16 93201 247 42527871
White blood cell count decreased 36.93 11.20 121 93096 110275 42417843
Poor feeding infant 36.92 11.20 23 93194 819 42527299
Inappropriate antidiuretic hormone secretion 36.86 11.20 99 93118 16442 42511676
Thrombosis 36.84 11.20 58 93159 68453 42459665
Potentiating drug interaction 36.59 11.20 57 93160 6411 42521707
Loss of consciousness 36.57 11.20 335 92882 92019 42436099
Newborn persistent pulmonary hypertension 36.50 11.20 13 93204 122 42527996
Paranoia 36.49 11.20 89 93128 13937 42514181
Thinking abnormal 36.26 11.20 60 93157 7101 42521017
Mental impairment 36.23 11.20 82 93135 12235 42515883
Pneumocystis jirovecii pneumonia 35.79 11.20 6 93211 25175 42502943
Pyramidal tract syndrome 35.46 11.20 16 93201 290 42527828
Neonatal tachypnoea 35.44 11.20 17 93200 356 42527762
Product substitution issue 35.28 11.20 77 93140 11213 42516905
Gastric infection 35.06 11.20 28 93189 1488 42526630
Radiation inflammation 34.66 11.20 24 93193 1024 42527094
Suicidal behaviour 34.58 11.20 28 93189 1518 42526600
Neonatal asphyxia 34.35 11.20 18 93199 458 42527660
Tubulointerstitial nephritis 34.32 11.20 13 93204 31535 42496583
Apgar score low 34.05 11.20 23 93194 942 42527176
Anticholinergic syndrome 33.90 11.20 28 93189 1561 42526557
Macrophages increased 33.80 11.20 13 93204 154 42527964
Neonatal toxicity 33.73 11.20 9 93208 27 42528091
Tremor neonatal 33.58 11.20 18 93199 480 42527638
Atrial fibrillation 33.57 11.20 174 93043 139419 42388699
Hallucination, tactile 33.45 11.20 19 93198 569 42527549
Multiple drug therapy 33.05 11.20 24 93193 1105 42527013
Poor weight gain neonatal 32.96 11.20 8 93209 14 42528104
Congenital hydrocephalus 32.93 11.20 13 93204 166 42527952
Spasmodic dysphonia 32.82 11.20 18 93199 503 42527615
Neonatal disorder 32.77 11.20 21 93196 786 42527332
Ejaculation disorder 32.33 11.20 23 93194 1025 42527093
Bone marrow failure 32.25 11.20 16 93201 33077 42495041
Homicidal ideation 32.20 11.20 35 93182 2759 42525359
Testicular atrophy 32.18 11.20 19 93198 613 42527505
Stevens-Johnson syndrome 32.15 11.20 5 93212 22173 42505945
Liver disorder 31.90 11.20 24 93193 39620 42488498
Anaphylactic reaction 31.75 11.20 28 93189 42715 42485403
Muscle mass 31.47 11.20 14 93203 245 42527873
Pneumonitis 31.39 11.20 27 93190 41691 42486427
Disorientation 31.35 11.20 160 93057 36229 42491889
Cardiac failure congestive 31.35 11.20 90 93127 85512 42442606
Pressure of speech 31.34 11.20 18 93199 551 42527567
Dissociative disorder 31.10 11.20 19 93198 653 42527465
Enuresis 30.93 11.20 34 93183 2714 42525404
Obstructive airways disorder 30.86 11.20 8 93209 24751 42503367
Joint swelling 30.82 11.20 64 93153 67958 42460160
False positive radioisotope investigation result 30.76 11.20 6 93211 0 42528118
Hypoxia 30.51 11.20 67 93150 69719 42458399
Encephalopathy neonatal 30.46 11.20 9 93208 43 42528075
Alopecia 30.32 11.20 13 93204 29263 42498855
Exposure via breast milk 30.26 11.20 32 93185 2445 42525673
Poor quality sleep 30.20 11.20 65 93152 9375 42518743
Electric shock 30.00 11.20 12 93205 159 42527959
Syndactyly 29.88 11.20 21 93196 918 42527200
Electrocardiogram QRS complex prolonged 29.77 11.20 49 93168 5774 42522344
Hepatocellular injury 29.36 11.20 116 93101 23562 42504556
Neonatal behavioural syndrome 29.34 11.20 12 93205 169 42527949
Decreased interest 29.24 11.20 33 93184 2712 42525406
Bronchopulmonary aspergillosis 29.05 11.20 4 93213 19425 42508693
Cerebral infarction 28.99 11.20 16 93201 31153 42496965
Heat stroke 28.96 11.20 22 93195 1086 42527032
Abnormal dreams 28.85 11.20 59 93158 8212 42519906
Suspected suicide 28.82 11.20 50 93167 6149 42521969
Logorrhoea 28.64 11.20 33 93184 2774 42525344
Coma scale abnormal 28.33 11.20 42 93175 4523 42523595
Myocardial fibrosis 28.32 11.20 23 93194 1252 42526866
Normal pressure hydrocephalus 28.24 11.20 12 93205 187 42527931
Thermophobia 28.08 11.20 9 93208 59 42528059
Loss of libido 27.87 11.20 34 93183 3036 42525082
Loose associations 27.82 11.20 9 93208 61 42528057
Plasma cell myeloma 27.80 11.20 38 93179 47540 42480578
Prostate cancer 27.79 11.20 34 93183 44609 42483509
Ascites 27.69 11.20 51 93166 56627 42471491
Cytopenia 27.64 11.20 3 93214 17494 42510624
Mutism 27.58 11.20 24 93193 1438 42526680
Rash maculo-papular 27.34 11.20 25 93192 37478 42490640
Dysphoria 27.23 11.20 32 93185 2748 42525370
Acoustic stimulation tests abnormal 27.09 11.20 9 93208 67 42528051
Obsessive-compulsive disorder 27.03 11.20 51 93166 6692 42521426
Confusion postoperative 27.02 11.20 11 93206 153 42527965
Mood altered 26.81 11.20 67 93150 10651 42517467
Neoplasm progression 26.81 11.20 15 93202 28985 42499133
Diverticulitis intestinal perforated 26.65 11.20 13 93204 283 42527835
Blood bilirubin increased 26.49 11.20 32 93185 42220 42485898
Implant site extravasation 26.45 11.20 15 93202 448 42527670
Upper respiratory tract infection 26.38 11.20 32 93185 42141 42485977
Chronic kidney disease 26.35 11.20 39 93178 47202 42480916
Urticaria 26.26 11.20 79 93138 73957 42454161
Pulmonary pain 26.00 11.20 24 93193 1554 42526564
Amnesia 25.89 11.20 127 93090 28310 42499808
Cognitive disorder 25.86 11.20 145 93072 34027 42494091
Lymphadenopathy 25.83 11.20 21 93196 33344 42494774
Muscle twitching 25.74 11.20 70 93147 11710 42516408
Disseminated intravascular coagulation 25.69 11.20 11 93206 24783 42503335
Neonatal testicular torsion 25.64 11.20 5 93212 0 42528118
Rhabdomyolysis 25.52 11.20 272 92945 77747 42450371
Persistent depressive disorder 25.40 11.20 15 93202 484 42527634
Respiratory arrest 25.20 11.20 126 93091 28298 42499820
Euphoric mood 24.88 11.20 48 93169 6405 42521713
International normalised ratio increased 24.75 11.20 42 93175 48126 42479992
Reversible cerebral vasoconstriction syndrome 24.60 11.20 17 93200 723 42527395
Patent ductus arteriosus 24.54 11.20 34 93183 3442 42524676
Opisthotonus 24.52 11.20 16 93201 618 42527500
Toxic epidermal necrolysis 24.50 11.20 14 93203 26736 42501382
Hospitalisation 24.48 11.20 82 93135 74248 42453870
Head discomfort 24.38 11.20 42 93175 5135 42522983
Violence-related symptom 24.26 11.20 15 93202 527 42527591
Status migrainosus 24.20 11.20 6 93211 12 42528106
Dry skin 24.06 11.20 43 93174 48295 42479823
Mood swings 24.03 11.20 57 93160 8769 42519349
Fall 23.97 11.20 677 92540 233843 42294275
Priapism 23.90 11.20 47 93170 6360 42521758
Hepatic function abnormal 23.80 11.20 48 93169 51519 42476599
Personality disorder 23.79 11.20 20 93197 1143 42526975
Synovitis 23.76 11.20 3 93214 15564 42512554
Swelling 23.73 11.20 53 93164 54832 42473286
Mental disorder 23.72 11.20 90 93127 17939 42510179
Neutrophil count decreased 23.71 11.20 66 93151 63349 42464769
Depersonalisation/derealisation disorder 23.67 11.20 16 93201 656 42527462
Mucosal inflammation 23.62 11.20 45 93172 49329 42478789
Blood ethanol increased 23.59 11.20 14 93203 456 42527662
Weight increased 23.53 11.20 349 92868 107634 42420484
Cardiotoxicity 23.52 11.20 51 93166 7394 42520724
Neonatal respiratory failure 23.33 11.20 13 93204 375 42527743
Spontaneous ejaculation 23.28 11.20 6 93211 15 42528103
Drug reaction with eosinophilia and systemic symptoms 23.21 11.20 35 93182 42040 42486078
Depressed level of consciousness 23.20 11.20 182 93035 47788 42480330
Palmar-plantar erythrodysaesthesia syndrome 23.20 11.20 8 93209 20574 42507544
Neonatal respiratory arrest 23.11 11.20 7 93210 37 42528081
Productive cough 22.96 11.20 49 93168 51518 42476600
Leukopenia 22.92 11.20 85 93132 74661 42453457
Fatigue 22.80 11.20 753 92464 434888 42093230
Neonatal respiratory distress 22.69 11.20 18 93199 947 42527171
Head circumference abnormal 22.65 11.20 7 93210 40 42528078
Renal failure 22.64 11.20 203 93014 143523 42384595
Kidney duplex 22.63 11.20 13 93204 398 42527720
Myasthenia gravis 22.59 11.20 4 93213 16133 42511985
Male orgasmic disorder 22.51 11.20 9 93208 119 42527999
Coagulation disorder neonatal 22.49 11.20 6 93211 18 42528100
Schizophrenia 22.37 11.20 62 93155 10488 42517630
Clinomania 22.36 11.20 7 93210 42 42528076
Splenomegaly 22.24 11.20 5 93212 17042 42511076
Iris coloboma 22.24 11.20 6 93211 19 42528099
External auditory canal atresia 22.17 11.20 10 93207 181 42527937
Congenital diaphragmatic hernia 22.16 11.20 11 93206 249 42527869
Acute myocardial infarction 22.15 11.20 60 93157 58105 42470013
Hangover 22.11 11.20 19 93198 1119 42526999
Retinal coloboma 22.01 11.20 6 93211 20 42528098
Toxic cardiomyopathy 21.94 11.20 13 93204 422 42527696
Product residue present 21.89 11.20 29 93188 2812 42525306
Megacolon 21.88 11.20 26 93191 2259 42525859
Epilepsy 21.80 11.20 114 93103 26057 42502061
Gun shot wound 21.56 11.20 18 93199 1019 42527099
Arachnoid cyst 21.50 11.20 11 93206 266 42527852
Renal aplasia 21.47 11.20 16 93201 767 42527351
Flat affect 21.41 11.20 18 93199 1029 42527089
Tumour lysis syndrome 21.28 11.20 11 93206 22220 42505898
Protein S decreased 21.25 11.20 8 93209 89 42528029
Hypokalaemia 21.06 11.20 83 93134 71638 42456480
Amblyopia 20.96 11.20 9 93208 144 42527974
Substance use disorder 20.90 11.20 40 93177 5305 42522813
Physical assault 20.89 11.20 18 93199 1064 42527054
Pulmonary contusion 20.86 11.20 8 93209 94 42528024
Skin exfoliation 20.65 11.20 37 93180 41516 42486602
Hypervigilance 20.63 11.20 9 93208 150 42527968
Tachycardia foetal 20.58 11.20 12 93205 378 42527740
Foetal hypokinesia 20.58 11.20 12 93205 378 42527740
Haemoptysis 20.44 11.20 44 93173 46123 42481995
Psychomotor skills impaired 20.42 11.20 39 93178 5165 42522953
Blunted affect 20.38 11.20 12 93205 385 42527733
Electrocardiogram QT shortened 20.31 11.20 9 93208 156 42527962
COVID-19 pneumonia 20.24 11.20 11 93206 21602 42506516
Decreased appetite 20.18 11.20 299 92918 192838 42335280
Deep vein thrombosis 20.17 11.20 93 93124 76864 42451254
Bradyphrenia 20.11 11.20 39 93178 5223 42522895
External ear disorder 20.08 11.20 6 93211 30 42528088
Gambling disorder 20.04 11.20 22 93195 1754 42526364
Fungal infection 20.04 11.20 9 93208 19713 42508405
Foetal malnutrition 19.93 11.20 8 93209 107 42528011
Nervousness 19.87 11.20 70 93147 13462 42514656
Visual evoked potentials abnormal 19.81 11.20 7 93210 64 42528054
Food aversion 19.79 11.20 13 93204 508 42527610
Forearm fracture 19.73 11.20 8 93209 110 42528008
Emotional disorder 19.66 11.20 43 93174 6271 42521847
Haematuria 19.56 11.20 63 93154 57736 42470382
Influenza 19.52 11.20 70 93147 62105 42466013
Pain in extremity 19.46 11.20 223 92994 150381 42377737
Phaeochromocytoma malignant 19.44 11.20 7 93210 68 42528050
Anhedonia 19.37 11.20 48 93169 7592 42520526
Myelodysplastic syndrome 19.31 11.20 13 93204 22732 42505386
Bradykinesia 19.22 11.20 39 93178 5397 42522721
Sleep paralysis 19.20 11.20 11 93206 335 42527783
No adverse event 19.16 11.20 35 93182 38986 42489132
Haemorrhage 19.14 11.20 68 93149 60495 42467623
Blepharospasm 19.12 11.20 19 93198 1349 42526769
Wheezing 19.04 11.20 59 93158 54722 42473396
C-reactive protein increased 19.02 11.20 73 93144 63487 42464631
Fear 19.01 11.20 60 93157 10905 42517213
Microcephaly 18.98 11.20 16 93201 918 42527200
Catatonia 18.87 11.20 42 93175 6197 42521921
Wrong dose 18.86 11.20 17 93200 1067 42527051
Ex-drug abuser 18.83 11.20 7 93210 75 42528043
Antidepressant drug level above therapeutic 18.75 11.20 10 93207 264 42527854
Bacterial infection 18.69 11.20 20 93197 27859 42500259
Bronchiectasis 18.66 11.20 8 93209 18011 42510107
Nephrogenic diabetes insipidus 18.64 11.20 20 93197 1554 42526564
Substance abuser 18.58 11.20 10 93207 269 42527849
Substance abuse 18.55 11.20 52 93165 8853 42519265
Psychomotor retardation 18.55 11.20 34 93183 4365 42523753
Ventricular septal defect 18.55 11.20 34 93183 4365 42523753
Anomalous pulmonary venous connection 18.52 11.20 8 93209 130 42527988
Histamine level increased 18.51 11.20 7 93210 79 42528039
Laboratory test abnormal 18.37 11.20 14 93203 22964 42505154
Poor sucking reflex 18.32 11.20 11 93206 366 42527752
Dyskinesia neonatal 18.28 11.20 4 93213 3 42528115
Product dose omission issue 18.26 11.20 233 92984 154132 42373986
Nephropathy toxic 18.21 11.20 7 93210 16831 42511287
Peritonitis 18.17 11.20 9 93208 18624 42509494
Psychiatric symptom 18.16 11.20 33 93184 4208 42523910
Aspergillus infection 18.12 11.20 6 93211 15831 42512287
Metabolic syndrome 18.06 11.20 22 93195 1961 42526157
Penoscrotal fusion 18.05 11.20 5 93212 18 42528100
Skull fractured base 18.04 11.20 9 93208 206 42527912
Urinary tract infection 18.02 11.20 135 93082 99149 42428969
Thrombotic microangiopathy 18.00 11.20 5 93212 14777 42513341
Pneumonia bacterial 17.86 11.20 6 93211 15686 42512432
Sleep disorder 17.79 11.20 172 93045 47923 42480195
Chronic idiopathic pain syndrome 17.78 11.20 8 93209 144 42527974
Peripheral swelling 17.72 11.20 120 93097 90150 42437968
End stage renal disease 17.71 11.20 7 93210 16551 42511567
Sensory disturbance 17.67 11.20 44 93173 6979 42521139
Ejaculation delayed 17.62 11.20 10 93207 299 42527819
Ventricular arrhythmia 17.58 11.20 41 93176 6238 42521880
Candida infection 17.49 11.20 13 93204 21597 42506521
Gastrointestinal hypermotility 17.39 11.20 8 93209 152 42527966
Infection parasitic 17.30 11.20 11 93206 406 42527712
Genital pain 17.29 11.20 15 93202 895 42527223
Tearfulness 17.28 11.20 29 93188 3471 42524647
Eczema 17.25 11.20 30 93187 34056 42494062
Acute myeloid leukaemia 17.24 11.20 14 93203 22242 42505876
Appendicitis 17.21 11.20 12 93205 20601 42507517
Food craving 17.19 11.20 12 93205 519 42527599
Trismus 17.14 11.20 26 93191 2858 42525260
Antipsychotic drug level increased 17.13 11.20 34 93183 4632 42523486
Congenital hand malformation 17.12 11.20 13 93204 641 42527477
Crying 17.09 11.20 41 93176 6353 42521765
Blood creatine phosphokinase increased 16.97 11.20 171 93046 48167 42479951
Haematochezia 16.92 11.20 68 93149 58368 42469750
Diarrhoea neonatal 16.90 11.20 5 93212 24 42528094
Abdominal distension 16.90 11.20 90 93127 71645 42456473
Impulse-control disorder 16.89 11.20 19 93198 1556 42526562
Pneumothorax 16.80 11.20 16 93201 23527 42504591
Social avoidant behaviour 16.78 11.20 28 93189 3336 42524782
Cerebrovascular accident 16.75 11.20 134 93083 97026 42431092
Chronic obstructive pulmonary disease 16.70 11.20 76 93141 63038 42465080
Hyperphosphataemia 16.60 11.20 4 93213 13000 42515118
Dysarthria 16.56 11.20 146 93071 39661 42488457
Otospondylomegaepiphyseal dysplasia 16.48 11.20 7 93210 109 42528009
Rash erythematous 16.47 11.20 28 93189 32063 42496055
Delusional disorder, persecutory type 16.33 11.20 10 93207 345 42527773
Hyperkalaemia 16.27 11.20 106 93111 80352 42447766
Tricuspid valve sclerosis 15.97 11.20 5 93212 30 42528088
Acidosis 15.91 11.20 61 93156 12218 42515900
Sleep-related eating disorder 15.90 11.20 10 93207 362 42527756
Full blood count decreased 15.84 11.20 13 93204 20547 42507571
Foaming at mouth 15.77 11.20 15 93202 1009 42527109
Back pain 15.67 11.20 217 93000 141559 42386559
Coagulation factor VII level decreased 15.66 11.20 7 93210 124 42527994
Micturition disorder 15.65 11.20 23 93194 2457 42525661
Anaphylactic shock 15.62 11.20 17 93200 23500 42504618
Cerebral ventricle dilatation 15.58 11.20 15 93202 1024 42527094
Hypotonia 15.58 11.20 51 93166 9448 42518670
Cardiac failure 15.50 11.20 154 93063 106702 42421416
Meningocele 15.44 11.20 5 93212 34 42528084
Drug screen false positive 15.41 11.20 14 93203 888 42527230
Kidney enlargement 15.40 11.20 14 93203 889 42527229
Selective mutism 15.39 11.20 6 93211 74 42528044
Kleptomania 15.38 11.20 3 93214 0 42528118
Duplicate therapy error 15.34 11.20 9 93208 287 42527831
Unemployment 15.32 11.20 5 93212 35 42528083
Cor pulmonale acute 15.25 11.20 9 93208 290 42527828
Catecholamines urine increased 15.25 11.20 4 93213 11 42528107
Hypophosphataemia 15.22 11.20 14 93203 20931 42507187
Renal disorder 15.13 11.20 25 93192 28955 42499163
Circulatory collapse 15.13 11.20 96 93121 23540 42504578
Hyponatraemic coma 15.08 11.20 5 93212 37 42528081
Blood lactate dehydrogenase increased 15.06 11.20 21 93196 26060 42502058
Pseudomonas infection 15.06 11.20 8 93209 15915 42512203
Respiratory symptom 15.02 11.20 3 93214 11103 42517015
Bruxism 14.99 11.20 21 93196 2148 42525970
Haemolytic anaemia 14.96 11.20 4 93213 12123 42515995
Contraindicated product administered 14.95 11.20 20 93197 25252 42502866
Cerebral microangiopathy 14.94 11.20 8 93209 213 42527905
Breath sounds abnormal 14.90 11.20 4 93213 12089 42516029
Accommodation disorder 14.87 11.20 9 93208 304 42527814
Delirium 14.86 11.20 178 93039 52341 42475777
Neonatal seizure 14.84 11.20 11 93206 523 42527595
Photopsia 14.83 11.20 22 93195 2370 42525748
Tachyphrenia 14.82 11.20 17 93200 1422 42526696
Haematoma 14.80 11.20 24 93193 27999 42500119
Urinary hesitation 14.79 11.20 25 93192 3010 42525108
Blood urea increased 14.73 11.20 31 93186 32762 42495356
Panic disorder 14.72 11.20 16 93201 1261 42526857
Spina bifida 14.71 11.20 10 93207 414 42527704
Cellulitis 14.65 11.20 77 93140 61508 42466610
Balance disorder 14.60 11.20 164 93053 47481 42480637
Obsessive-compulsive symptom 14.57 11.20 8 93209 224 42527894
Cerebellar syndrome 14.56 11.20 24 93193 2831 42525287
Atypical haemolytic uraemic syndrome 14.39 11.20 11 93206 548 42527570
Infantile haemangioma 14.39 11.20 6 93211 89 42528029
Accidental exposure to product 14.39 11.20 14 93203 20379 42507739
Spondylolisthesis 14.37 11.20 13 93204 820 42527298
Chest discomfort 14.33 11.20 81 93136 63535 42464583
Action tremor 14.33 11.20 6 93211 90 42528028
Rhinorrhoea 14.33 11.20 30 93187 31764 42496354
Alcohol abuse 14.26 11.20 29 93188 4020 42524098
Squamous cell carcinoma of skin 14.25 11.20 5 93212 12721 42515397
Laryngomalacia 14.23 11.20 9 93208 329 42527789
Respiratory depression 14.23 11.20 80 93137 18788 42509330
Congenital central nervous system anomaly 14.17 11.20 12 93205 693 42527425
Oedema 14.13 11.20 62 93155 51939 42476179
Arthritis 14.13 11.20 46 93171 42019 42486099
Dyspnoea exertional 14.11 11.20 59 93158 50089 42478029
Urinary straining 14.11 11.20 4 93213 16 42528102
Derealisation 14.08 11.20 13 93204 842 42527276
Dizziness 14.03 11.20 673 92544 248581 42279537
Injection site swelling 14.01 11.20 10 93207 16963 42511155
Flight of ideas 13.99 11.20 9 93208 339 42527779
Aspartate aminotransferase increased 13.96 11.20 105 93112 77058 42451060
Blood potassium increased 13.94 11.20 12 93205 18524 42509594
Paraesthesia 13.93 11.20 232 92985 73227 42454891
Painful erection 13.92 11.20 9 93208 342 42527776
Food interaction 13.92 11.20 14 93203 1008 42527110
Norepinephrine increased 13.91 11.20 4 93213 17 42528101
Urinary incontinence 13.86 11.20 88 93129 21580 42506538
Limited symptom panic attack 13.85 11.20 5 93212 49 42528069
Therapy partial responder 13.83 11.20 14 93203 20007 42508111
Hypersomnia 13.82 11.20 66 93151 14552 42513566
CADASIL 13.81 11.20 6 93211 99 42528019
Hallucination 13.77 11.20 189 93028 57318 42470800
Genital anaesthesia 13.73 11.20 4 93213 18 42528100
Feeling of despair 13.69 11.20 15 93202 1193 42526925
Neutropenic sepsis 13.69 11.20 9 93208 15937 42512181
Therapeutic response unexpected 13.50 11.20 55 93162 11326 42516792
Jaundice neonatal 13.45 11.20 20 93197 2159 42525959
Rebound effect 13.37 11.20 41 93176 7338 42520780
Sexually inappropriate behaviour 13.34 11.20 11 93206 612 42527506
Rectal fissure 13.34 11.20 9 93208 368 42527750
Non-compaction cardiomyopathy 13.33 11.20 5 93212 55 42528063
Eye degenerative disorder 13.31 11.20 3 93214 3 42528115
Sinus tachycardia 13.29 11.20 84 93133 20569 42507549
Cardiac arrest 13.29 11.20 323 92894 108997 42419121
Dissociative identity disorder 13.23 11.20 4 93213 21 42528097
Hyperlactacidaemia 13.21 11.20 30 93187 4486 42523632
Immune reconstitution inflammatory syndrome 13.18 11.20 3 93214 10140 42517978
Heart rate increased 13.15 11.20 176 93041 53079 42475039
Attention deficit hyperactivity disorder 13.08 11.20 24 93193 3084 42525034
Breech presentation 12.98 11.20 7 93210 189 42527929
Convulsive threshold lowered 12.96 11.20 10 93207 505 42527613
Craniocerebral injury 12.96 11.20 27 93190 3807 42524311
Drug eruption 12.91 11.20 19 93198 23056 42505062
Congenital hydronephrosis 12.89 11.20 12 93205 785 42527333
Self esteem decreased 12.84 11.20 10 93207 512 42527606
Double inlet left ventricle 12.78 11.20 4 93213 24 42528094
Ear infection 12.76 11.20 6 93211 12798 42515320
Bacteraemia 12.71 11.20 22 93195 25018 42503100
Anorgasmia 12.68 11.20 14 93203 1123 42526995
Social (pragmatic) communication disorder 12.67 11.20 6 93211 122 42527996
Bite 12.67 11.20 6 93211 122 42527996
Pre-existing condition improved 12.62 11.20 23 93194 2940 42525178
Affective disorder 12.61 11.20 35 93182 5925 42522193
Orgasmic sensation decreased 12.58 11.20 5 93212 65 42528053
Melaena 12.58 11.20 43 93174 38703 42489415
Congestive cardiomyopathy 12.58 11.20 45 93172 8719 42519399
Hallucinations, mixed 12.57 11.20 25 93192 3410 42524708
Hyperbilirubinaemia 12.54 11.20 16 93201 20619 42507499
Rash pruritic 12.54 11.20 35 93182 33568 42494550
Sudden cardiac death 12.53 11.20 27 93190 3897 42524221
Cardiac death 12.53 11.20 14 93203 1138 42526980
Conjunctivitis viral 12.52 11.20 5 93212 66 42528052
Onychophagia 12.52 11.20 5 93212 66 42528052
Anal incontinence 12.48 11.20 47 93170 9334 42518784
Sinusitis 12.48 11.20 57 93160 47235 42480883
Hypersensitivity 12.38 11.20 100 93117 72270 42455848
Colitis 12.37 11.20 56 93161 46516 42481602
Extrasystoles 12.36 11.20 28 93189 4181 42523937
Gastrointestinal bacterial infection 12.35 11.20 11 93206 680 42527438
Cerebellar haematoma 12.34 11.20 7 93210 209 42527909
Onychomycosis 12.34 11.20 22 93195 2764 42525354
Depression suicidal 12.34 11.20 24 93193 3221 42524897
Abscess 12.29 11.20 8 93209 14240 42513878
Flashback 12.24 11.20 6 93211 132 42527986
Diastolic hypotension 12.22 11.20 7 93210 213 42527905
Foetal arrhythmia 12.20 11.20 6 93211 133 42527985
Pseudohyponatraemia 12.20 11.20 6 93211 133 42527985
Retinopathy hypertensive 12.19 11.20 8 93209 312 42527806
Cerebral disorder 12.14 11.20 23 93194 3027 42525091
Congenital skin dimples 12.14 11.20 7 93210 216 42527902
Muscle tightness 12.13 11.20 33 93184 5520 42522598
Eosinophilic myocarditis 12.13 11.20 15 93202 1358 42526760
Congenital ureterocele 12.10 11.20 3 93214 6 42528112
Right ventricular failure 12.08 11.20 3 93214 9552 42518566
Hypercalcaemia 12.05 11.20 13 93204 18045 42510073
Illusion 12.05 11.20 13 93204 1016 42527102
Schizoaffective disorder 12.05 11.20 18 93199 1952 42526166
Aplastic anaemia 12.04 11.20 6 93211 12378 42515740
Large intestine perforation 12.04 11.20 3 93214 9533 42518585
Pancreatic carcinoma 11.99 11.20 3 93214 9503 42518615
Affect lability 11.98 11.20 27 93190 4017 42524101
Hepatotoxicity 11.98 11.20 23 93194 25144 42502974
Eye pruritus 11.92 11.20 5 93212 11407 42516711
Magnetic resonance imaging spinal abnormal 11.92 11.20 6 93211 140 42527978
Diffuse large B-cell lymphoma 11.89 11.20 3 93214 9451 42518667
Muscle necrosis 11.89 11.20 13 93204 1032 42527086
Road traffic accident 11.88 11.20 77 93140 19016 42509102
Rectal haemorrhage 11.81 11.20 62 93155 49544 42478574
Ischaemic stroke 11.78 11.20 19 93198 22214 42505904
Genital ulceration 11.76 11.20 12 93205 879 42527239
Dehydration 11.70 11.20 229 92988 141538 42386580
Bladder cancer 11.68 11.20 12 93205 17035 42511083
General physical health deterioration 11.68 11.20 247 92970 150999 42377119
Left ventricular dysfunction 11.66 11.20 53 93164 11448 42516670
Liver function test increased 11.65 11.20 16 93201 19982 42508136
Postoperative delirium 11.62 11.20 10 93207 590 42527528
Tunnel vision 11.61 11.20 10 93207 591 42527527
Hydrops foetalis 11.61 11.20 12 93205 893 42527225
Stupor 11.60 11.20 23 93194 3130 42524988
Genital hypoaesthesia 11.58 11.20 7 93210 236 42527882
Repetitive speech 11.53 11.20 5 93212 82 42528036
Graft versus host disease 11.50 11.20 7 93210 12918 42515200
Chills 11.48 11.20 141 93076 93925 42434193
Product storage error 11.45 11.20 5 93212 11135 42516983
Incoherent 11.42 11.20 29 93188 4656 42523462
Univentricular heart 11.38 11.20 4 93213 36 42528082
Bezoar 11.37 11.20 14 93203 1262 42526856
Oropharyngeal pain 11.36 11.20 51 93166 42459 42485659
Lip swelling 11.35 11.20 15 93202 19038 42509080
Iron deficiency 11.31 11.20 5 93212 11056 42517062
Inhibitory drug interaction 11.28 11.20 17 93200 1857 42526261
Lip pruritus 11.28 11.20 4 93213 37 42528081
Necrotising ulcerative gingivostomatitis 11.27 11.20 5 93212 87 42528031
Coronary artery disease 11.25 11.20 70 93147 53650 42474468
Dysgraphia 11.25 11.20 20 93197 2508 42525610
Relapsing multiple sclerosis 11.24 11.20 3 93214 9 42528109
Ocular hyperaemia 11.21 11.20 11 93206 15952 42512166
Haemophagocytic lymphohistiocytosis 11.21 11.20 14 93203 18208 42509910

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3284.79 9.99 3463 264465 238918 110082453
Serotonin syndrome 2548.96 9.99 1658 266270 57495 110263876
Toxicity to various agents 2143.68 9.99 4022 263906 476533 109844838
Intentional overdose 1988.80 9.99 2002 265926 130499 110190872
Suicide attempt 1879.34 9.99 1736 266192 101658 110219713
Suicidal ideation 1547.83 9.99 1494 266434 92443 110228928
Overdose 1388.02 9.99 2223 265705 231571 110089800
Drug withdrawal syndrome 1093.76 9.99 833 267095 37221 110284150
Coma 980.71 9.99 1315 266613 116554 110204817
Drug abuse 968.58 9.99 1625 266303 175786 110145585
Poisoning deliberate 884.03 9.99 633 267295 25698 110295673
Drug interaction 817.15 9.99 2865 265063 497318 109824053
Hyperhidrosis 751.66 9.99 1502 266426 185796 110135575
Intentional self-injury 733.38 9.99 656 267272 36773 110284598
Withdrawal syndrome 656.80 9.99 571 267357 30809 110290562
Sopor 610.46 9.99 586 267342 35960 110285411
Mydriasis 558.64 9.99 449 267479 21708 110299663
Somnolence 531.53 9.99 1757 266171 295692 110025679
Synovitis 529.75 9.99 34 267894 274058 110047313
Agitation 526.36 9.99 966 266962 112085 110209286
Electrocardiogram QT prolonged 522.46 9.99 943 266985 108017 110213354
Pemphigus 501.88 9.99 3 267925 214567 110106804
Hand deformity 465.02 9.99 14 267914 218492 110102879
Tremor 440.31 9.99 1280 266648 200952 110120419
Systemic lupus erythematosus 419.36 9.99 59 267869 254279 110067092
Pericarditis 395.76 9.99 37 267891 219077 110102294
Helicobacter infection 389.39 9.99 11 267917 181866 110139505
Duodenal ulcer perforation 387.04 9.99 9 267919 177691 110143680
Glossodynia 386.68 9.99 43 267885 221961 110099410
Nightmare 381.69 9.99 471 267457 38392 110282979
Anxiety 359.05 9.99 1721 266207 343357 109978014
Depressed mood 355.66 9.99 575 267353 60234 110261137
Seizure 342.19 9.99 1246 266682 219939 110101432
Folliculitis 320.31 9.99 22 267906 167631 110153740
Generalised tonic-clonic seizure 318.36 9.99 516 267412 54164 110267207
Sedation 307.44 9.99 582 267346 69101 110252270
Depression 302.54 9.99 1544 266384 315791 110005580
Akathisia 302.13 9.99 283 267645 16830 110304541
Cardio-respiratory arrest 298.44 9.99 780 267148 115056 110206315
Rheumatoid factor positive 293.34 9.99 5 267923 131635 110189736
Stomatitis 290.12 9.99 146 267782 270096 110051275
Disturbance in attention 290.02 9.99 531 267397 61464 110259907
Wound 286.13 9.99 105 267823 234332 110087039
Muscle injury 285.86 9.99 13 267915 140794 110180577
Rheumatic fever 280.35 9.99 3 267925 122576 110198795
Febrile neutropenia 275.64 9.99 218 267710 316549 110004822
Impaired healing 270.72 9.99 71 267857 196646 110124725
Intentional product misuse 269.91 9.99 821 267107 132083 110189288
Pneumonia 268.38 9.99 1153 266775 875561 109445810
Swelling 264.49 9.99 276 267652 350765 109970606
C-reactive protein abnormal 253.75 9.99 15 267913 129680 110191691
Alopecia 252.74 9.99 307 267621 364446 109956925
Arthropathy 249.98 9.99 198 267730 287324 110034047
Mania 245.59 9.99 277 267651 20519 110300852
Irritability 238.31 9.99 421 267507 47388 110273983
Foetal death 228.58 9.99 236 267692 15809 110305562
Drug dependence 223.39 9.99 420 267508 49600 110271771
Psoriatic arthropathy 219.23 9.99 101 267827 196660 110124711
Crying 217.62 9.99 289 267639 25339 110296032
Altered state of consciousness 215.29 9.99 449 267479 57177 110264194
Poisoning 215.23 9.99 307 267621 28798 110292573
Extrapyramidal disorder 212.75 9.99 304 267624 28563 110292808
Psychomotor hyperactivity 212.51 9.99 254 267674 20023 110301348
Blister 209.98 9.99 147 267781 227229 110094142
Infusion related reaction 208.37 9.99 378 267550 380784 109940587
Tachycardia 205.64 9.99 1088 266840 225557 110095814
Joint swelling 203.47 9.99 485 267443 442360 109879011
Joint range of motion decreased 201.35 9.99 28 267900 121804 110199567
Feeling abnormal 199.94 9.99 918 267010 179793 110141578
Respiratory arrest 199.11 9.99 438 267490 57861 110263510
Restlessness 198.20 9.99 428 267500 55831 110265540
Lip dry 197.55 9.99 11 267917 100072 110221299
Sleep disorder due to general medical condition, insomnia type 192.95 9.99 17 267911 105626 110215745
Irritable bowel syndrome 192.95 9.99 78 267850 164137 110157234
Facet joint syndrome 190.02 9.99 11 267917 96817 110224554
Stress cardiomyopathy 187.44 9.99 211 267717 15595 110305776
Cardiac arrest 187.10 9.99 957 266971 195796 110125575
Ill-defined disorder 185.11 9.99 74 267854 156779 110164592
Sinus tachycardia 178.42 9.99 357 267571 44136 110277235
Breast cancer stage III 176.27 9.99 3 267925 79114 110242257
Pyrexia 175.79 9.99 1365 266563 896900 109424471
Myelosuppression 175.55 9.99 14 267914 94326 110227045
Mobility decreased 175.02 9.99 190 267738 237232 110084139
Rash 172.81 9.99 1222 266706 819742 109501629
Infection 171.69 9.99 390 267538 361810 109959561
Hallucination, auditory 171.50 9.99 262 267666 26135 110295236
Hallucination, visual 171.22 9.99 328 267600 39277 110282094
Panic attack 171.02 9.99 275 267653 28665 110292706
Aggression 170.50 9.99 416 267512 58794 110262577
Hyperreflexia 169.64 9.99 158 267770 9327 110312044
Anger 168.61 9.99 219 267709 18788 110302583
Major depression 167.37 9.99 165 267763 10456 110310915
Electrocardiogram QRS complex prolonged 166.80 9.99 181 267747 12840 110308531
Neuroleptic malignant syndrome 165.98 9.99 297 267631 33762 110287609
Anaemia 162.50 9.99 727 267201 546359 109775012
Disease progression 160.02 9.99 214 267714 243820 110077551
Peripheral swelling 158.71 9.99 478 267450 403556 109917815
Neutropenia 156.81 9.99 430 267498 374190 109947181
Therapeutic product effect decreased 155.42 9.99 219 267709 244097 110077274
Myoclonus 154.76 9.99 283 267645 32715 110288656
Sepsis 153.89 9.99 354 267574 326992 109994379
Muscle rigidity 152.58 9.99 236 267692 23795 110297576
Delusion 151.83 9.99 234 267694 23521 110297850
Temperature regulation disorder 151.72 9.99 171 267757 12655 110308716
Oedema 151.50 9.99 171 267757 209805 110111566
Peripheral venous disease 147.15 9.99 16 267912 84101 110237270
C-reactive protein increased 143.99 9.99 190 267738 217729 110103642
Wound infection 142.20 9.99 30 267898 96435 110224936
Fibromyalgia 140.71 9.99 124 267804 170785 110150586
Loss of consciousness 140.51 9.99 885 267043 195421 110125950
Lung disorder 138.40 9.99 139 267789 179908 110141463
Discomfort 137.02 9.99 192 267736 214515 110106856
Gestational diabetes 135.85 9.99 125 267803 7264 110314107
Bipolar disorder 134.69 9.99 136 267792 8871 110312500
Wheezing 130.75 9.99 263 267665 254967 110066404
Contraindicated product administered 130.48 9.99 252 267676 248015 110073356
Lower respiratory tract infection 130.18 9.99 244 267684 242862 110078509
Nasopharyngitis 130.10 9.99 503 267425 393858 109927513
Cataplexy 129.10 9.99 61 267867 1108 110320263
Tardive dyskinesia 127.59 9.99 161 267767 13418 110307953
Parkinsonism 127.25 9.99 208 267720 21979 110299392
Antidepressant drug level above therapeutic 127.12 9.99 53 267875 704 110320667
Homicide 126.11 9.99 59 267869 1047 110320324
Galactorrhoea 126.08 9.99 94 267834 4061 110317310
Platelet count decreased 125.42 9.99 229 267699 230214 110091157
Inspiratory capacity decreased 124.72 9.99 78 267850 2517 110318854
Disorientation 124.64 9.99 416 267512 70255 110251116
Grip strength decreased 124.38 9.99 22 267906 80152 110241219
Restless legs syndrome 124.19 9.99 218 267710 24408 110296963
Depressed level of consciousness 123.85 9.99 570 267358 111708 110209663
Apathy 122.59 9.99 173 267755 16066 110305305
Cardiogenic shock 120.86 9.99 359 267569 56979 110264392
Gastrointestinal disorder 120.81 9.99 253 267675 241699 110079672
Osteoarthritis 119.85 9.99 160 267768 182463 110138908
Malignant neoplasm progression 119.67 9.99 148 267780 174419 110146952
Dyskinesia 118.97 9.99 333 267595 51113 110270258
General physical health deterioration 118.61 9.99 578 267350 424717 109896654
Cardiotoxicity 117.43 9.99 173 267755 16708 110304663
Maternal exposure during pregnancy 116.27 9.99 280 267648 254603 110066768
Clonus 114.88 9.99 123 267805 8593 110312778
Mood swings 111.25 9.99 199 267729 22613 110298758
Abdominal discomfort 111.14 9.99 533 267395 393325 109928046
Antidepressant discontinuation syndrome 110.22 9.99 32 267896 125 110321246
Sinusitis 109.41 9.99 361 267567 296327 110025044
Arthralgia 109.15 9.99 1286 266642 778346 109543025
Product substitution issue 108.42 9.99 198 267730 22863 110298508
Food allergy 107.69 9.99 182 267746 19766 110301605
Psychotic disorder 106.49 9.99 318 267610 50619 110270752
Antidepressant drug level increased 106.38 9.99 44 267884 572 110320799
Liver disorder 104.61 9.99 114 267814 142129 110179242
Live birth 103.67 9.99 21 267907 69463 110251908
Thinking abnormal 103.65 9.99 154 267774 14986 110306385
Mental disorder 102.71 9.99 264 267664 38527 110282844
Mental impairment 102.19 9.99 191 267737 22448 110298923
Nervousness 101.95 9.99 255 267673 36596 110284775
Liver injury 101.55 9.99 129 267799 150284 110171087
Psychomotor retardation 101.01 9.99 109 267819 7683 110313688
Reversible cerebral vasoconstriction syndrome 100.33 9.99 87 267841 4674 110316697
Hyponatraemia 99.25 9.99 882 267046 216771 110104600
Bone erosion 98.50 9.99 3 267925 46368 110275003
Intentional product use issue 98.20 9.99 292 267636 247614 110073757
Inflammation 96.51 9.99 202 267726 193036 110128335
Somnambulism 96.31 9.99 97 267831 6308 110315063
Red blood cell sedimentation rate increased 95.60 9.99 35 267893 78267 110243104
Bezoar 95.53 9.99 79 267849 3975 110317396
Dyspnoea 94.19 9.99 2006 265922 1104866 109216505
Cytokine release syndrome 93.64 9.99 27 267901 70279 110251092
Dislocation of vertebra 92.25 9.99 3 267925 43718 110277653
Nail disorder 91.85 9.99 15 267913 57920 110263451
Musculoskeletal stiffness 91.54 9.99 358 267570 279464 110041907
Taste disorder 91.07 9.99 23 267905 65364 110256007
Tearfulness 89.88 9.99 100 267828 7295 110314076
Autoimmune disorder 89.35 9.99 24 267904 65459 110255912
Respiratory depression 89.12 9.99 222 267706 31779 110289592
Urticaria 88.48 9.99 434 267494 318423 110002948
Abnormal behaviour 87.63 9.99 250 267678 38789 110282582
Drug use disorder 87.28 9.99 157 267771 17917 110303454
Injury 87.10 9.99 187 267741 177078 110144293
Pancytopenia 86.59 9.99 242 267686 209371 110112000
Off label use 85.23 9.99 2881 265047 1497304 108824067
Hepatic enzyme increased 84.93 9.99 444 267484 320448 110000923
Urinary incontinence 83.89 9.99 284 267644 48303 110273068
Pyramidal tract syndrome 83.84 9.99 41 267887 806 110320565
Hypercholesterolaemia 83.45 9.99 59 267869 90778 110230593
Liver function test increased 83.36 9.99 56 267872 88492 110232879
Pruritus 82.95 9.99 955 266973 580605 109740766
Hypertonia 82.71 9.99 102 267826 8304 110313067
Drug ineffective for unapproved indication 82.69 9.99 478 267450 102360 110219011
Cytomegalovirus infection 82.18 9.99 16 267912 54428 110266943
Paranoia 82.00 9.99 173 267755 22201 110299170
Pulmonary fibrosis 81.63 9.99 76 267852 101966 110219405
Lung diffusion test abnormal 81.27 9.99 32 267896 363 110321008
Inappropriate antidiuretic hormone secretion 81.12 9.99 222 267706 33629 110287742
Septic shock 80.92 9.99 162 267766 157366 110164005
Diarrhoea 80.86 9.99 2123 265805 1137382 109183989
False positive radioisotope investigation result 80.31 9.99 17 267911 6 110321365
Decorticate posture 80.23 9.99 31 267897 333 110321038
Hyperprolactinaemia 80.06 9.99 89 267839 6486 110314885
Suicidal behaviour 80.03 9.99 67 267861 3430 110317941
Blood cholesterol increased 79.58 9.99 209 267719 184576 110136795
Erectile dysfunction 79.37 9.99 153 267775 18403 110302968
Dissociation 79 9.99 108 267820 9734 110311637
Impulsive behaviour 78.96 9.99 65 267863 3250 110318121
Hypomania 78.89 9.99 110 267818 10100 110311271
Self-injurious ideation 78.89 9.99 73 267855 4273 110317098
Euphoric mood 78.75 9.99 102 267826 8725 110312646
Coma scale abnormal 78.48 9.99 107 267821 9619 110311752
Insomnia 78.31 9.99 1268 266660 359322 109962049
Renal impairment 78.25 9.99 217 267711 188228 110133143
Neovascularisation 77.96 9.99 50 267878 1687 110319684
Sleep-related eating disorder 77.52 9.99 40 267888 885 110320486
Fall 77.29 9.99 1961 265967 601521 109719850
Hallucination 76.75 9.99 464 267464 100968 110220403
Abnormal dreams 76.27 9.99 122 267806 12658 110308713
Urinary retention 76.27 9.99 353 267575 69330 110252041
Social anxiety disorder 75.89 9.99 40 267888 926 110320445
Homicidal ideation 75.87 9.99 66 267862 3561 110317810
Cognitive disorder 75.14 9.99 414 267514 87097 110234274
Adjustment disorder with depressed mood 75.11 9.99 9 267919 43874 110277497
Colitis microscopic 74.70 9.99 124 267804 13270 110308101
Onychomadesis 74.26 9.99 11 267917 45652 110275719
Myocardial depression 74.16 9.99 36 267892 696 110320675
Libido decreased 73.41 9.99 81 267847 5854 110315517
Physical assault 73.41 9.99 47 267881 1581 110319790
Rhabdomyolysis 71.83 9.99 519 267409 119882 110201489
Miosis 71.50 9.99 162 267766 21821 110299550
Electric shock sensation 70.48 9.99 49 267879 1895 110319476
Hip arthroplasty 69.75 9.99 24 267904 55789 110265582
Suspected suicide 69.57 9.99 129 267799 15070 110306301
Abulia 69.56 9.99 42 267886 1271 110320100
Musculoskeletal pain 69.32 9.99 220 267708 182803 110138568
Pleural effusion 69.15 9.99 211 267717 177498 110143873
Oedema peripheral 69.02 9.99 489 267439 328171 109993200
Logorrhoea 68.97 9.99 72 267856 4885 110316486
Neuropathy peripheral 68.95 9.99 214 267714 179063 110142308
Feelings of worthlessness 68.90 9.99 32 267896 558 110320813
Vertigo 68.68 9.99 402 267526 86468 110234903
Camptocormia 68.20 9.99 30 267898 458 110320913
Pulmonary pain 67.87 9.99 80 267848 6213 110315158
Lymphocytic oesophagitis 67.73 9.99 18 267910 46 110321325
Malignant mediastinal neoplasm 67.69 9.99 42 267886 1336 110320035
Psychotic symptom 66.44 9.99 63 267865 3804 110317567
Persecutory delusion 66.24 9.99 79 267849 6212 110315159
Dissociative disorder 66.24 9.99 40 267888 1211 110320160
Pneumocystis jirovecii pneumonia 65.69 9.99 12 267916 42723 110278648
Mood altered 65.64 9.99 154 267774 21221 110300150
Retinitis 65.54 9.99 3 267925 32324 110289047
Gait inability 65.23 9.99 146 267782 136230 110185141
Anticholinergic syndrome 64.69 9.99 65 267863 4215 110317156
Loss of libido 63.51 9.99 56 267872 3077 110318294
Somatic symptom disorder 63.11 9.99 56 267872 3103 110318268
Accommodation disorder 62.82 9.99 31 267897 622 110320749
Emotional disorder 62.79 9.99 128 267800 16032 110305339
Amyloid arthropathy 62.45 9.99 43 267885 1637 110319734
Postmortem blood drug level increased 62.09 9.99 38 267890 1179 110320192
Rheumatoid arthritis 61.34 9.99 449 267479 299164 110022207
Libido increased 60.92 9.99 50 267878 2489 110318882
Bone marrow failure 60.91 9.99 32 267896 57816 110263555
Hypothermia 60.56 9.99 170 267758 26132 110295239
Headache 60.55 9.99 2664 265264 879713 109441658
Hostility 60.35 9.99 51 267877 2645 110318726
Haemoglobin decreased 59.87 9.99 355 267573 248372 110072999
Blood creatinine increased 59.77 9.99 234 267694 182655 110138716
Pneumonia aspiration 58.55 9.99 367 267561 80866 110240505
Muscle twitching 58.00 9.99 182 267746 29753 110291618
Accidental death 57.91 9.99 66 267862 4943 110316428
Hallucination, tactile 57.77 9.99 34 267894 981 110320390
Head discomfort 57.38 9.99 136 267792 18864 110302507
Nystagmus 56.46 9.99 101 267827 11476 110309895
Blepharospasm 55.35 9.99 32 267896 54819 110266552
Rapid eye movement sleep behaviour disorder 54.61 9.99 28 267900 611 110320760
Benzodiazepine drug level increased 54.24 9.99 21 267907 227 110321144
Social avoidant behaviour 54.21 9.99 66 267862 5303 110316068
Confusional state 53.90 9.99 1502 266426 467178 109854193
Hot flush 53.77 9.99 308 267620 65728 110255643
Lower limb fracture 53.62 9.99 62 267866 75286 110246085
Type 2 diabetes mellitus 53.41 9.99 234 267694 176998 110144373
Panic disorder 53.11 9.99 53 267875 3408 110317963
Sexual dysfunction 53.07 9.99 83 267845 8447 110312924
Night sweats 52.89 9.99 158 267770 133825 110187546
Hypersensitivity 52.38 9.99 677 267251 403321 109918050
Alcohol interaction 52.01 9.99 54 267874 3640 110317731
Meconium in amniotic fluid 51.70 9.99 18 267910 140 110321231
Osteoporosis 51.62 9.99 82 267846 87070 110234301
Drug tolerance decreased 51.47 9.99 4 267924 27536 110293835
Speech disorder 51.34 9.99 289 267639 61280 110260091
Hypersomnia 51.09 9.99 167 267761 27894 110293477
Paroxysmal perceptual alteration 51.05 9.99 21 267907 269 110321102
Opsoclonus myoclonus 51.05 9.99 21 267907 269 110321102
Congestive cardiomyopathy 51.01 9.99 109 267819 14110 110307261
Victim of crime 50.47 9.99 35 267893 1348 110320023
Concussion 50.41 9.99 96 267832 11442 110309929
Vision blurred 50.38 9.99 506 267422 128516 110192855
Swollen tongue 50.11 9.99 283 267645 60079 110261292
Alcoholism 50.07 9.99 53 267875 3654 110317717
Endometriosis 49.93 9.99 57 267871 4277 110317094
Bruxism 49.79 9.99 61 267867 4933 110316438
Pain in extremity 49.46 9.99 856 267072 486262 109835109
Drug screen positive 49.44 9.99 69 267859 6341 110315030
Toxic epidermal necrolysis 49.33 9.99 39 267889 56688 110264683
Dysphonia 49.21 9.99 334 267594 75595 110245776
Abdominal pain upper 49.04 9.99 575 267353 348536 109972835
Thrombocytopenia 48.48 9.99 576 267352 348309 109973062
Depressive symptom 48.41 9.99 79 267849 8335 110313036
Balance disorder 48.37 9.99 463 267465 116097 110205274
Nephrolithiasis 48.26 9.99 300 267628 65912 110255459
Bradyphrenia 48.09 9.99 95 267833 11633 110309738
Lactic acidosis 48.03 9.99 387 267541 92424 110228947
Ventricular tachycardia 48.00 9.99 244 267684 49765 110271606
Hepatocellular injury 47.85 9.99 246 267682 50396 110270975
Hallucinations, mixed 47.84 9.99 80 267848 8613 110312758
Treatment failure 47.37 9.99 436 267492 276798 110044573
Drug level increased 47.34 9.99 235 267693 47484 110273887
Obsessive-compulsive disorder 47.21 9.99 72 267856 7169 110314202
Adverse event 46.89 9.99 123 267805 108686 110212685
Inappropriate affect 46.19 9.99 36 267892 1663 110319708
Breast cancer stage II 45.91 9.99 6 267922 27369 110294002
Dizziness 45.43 9.99 2097 265831 696096 109625275
Pleurothotonus 45.42 9.99 42 267886 2456 110318915
Drug hypersensitivity 45.34 9.99 1430 266498 452660 109868711
Panic reaction 45.15 9.99 60 267868 5262 110316109
Feeling jittery 45.13 9.99 106 267822 14616 110306755
Bronchopulmonary aspergillosis 44.60 9.99 9 267919 29854 110291517
Product quality issue 44.59 9.99 74 267854 77225 110244146
Antipsychotic drug level above therapeutic 44.32 9.99 41 267887 2399 110318972
Metabolic acidosis 44.30 9.99 402 267526 99342 110222029
Tension 44.24 9.99 58 267870 5020 110316351
Dysarthria 44.20 9.99 352 267576 83769 110237602
Pre-eclampsia 44.17 9.99 77 267851 8573 110312798
Obesity 43.79 9.99 135 267793 113216 110208155
Arthritis 43.67 9.99 233 267695 167353 110154018
Dysphoria 43.45 9.99 65 267863 6363 110315008
Sciatica 43.30 9.99 100 267828 92299 110229072
Product label confusion 43.22 9.99 3 267925 22674 110298697
Hospitalisation 43.01 9.99 188 267740 142305 110179066
Substance abuse 42.95 9.99 94 267834 12369 110309002
Heart rate increased 42.90 9.99 535 267393 143299 110178072
Nervous system disorder 42.63 9.99 171 267757 31550 110289821
Enuresis 42.41 9.99 51 267877 4045 110317326
Atrial fibrillation 42.39 9.99 354 267574 229288 110092083
Colitis 42.34 9.99 118 267810 102205 110219166
Lupus-like syndrome 42.31 9.99 23 267905 40769 110280602
Blood creatine phosphokinase increased 41.86 9.99 312 267616 72765 110248606
Blood bilirubin increased 41.75 9.99 75 267853 75897 110245474
Pain 41.73 9.99 1890 266038 953065 109368306
Persistent depressive disorder 41.69 9.99 32 267896 1445 110319926
Ascites 41.46 9.99 103 267825 92705 110228666
Cytopenia 41.16 9.99 11 267917 30105 110291266
Cerebral infarction 41.00 9.99 39 267889 51799 110269572
White blood cell count decreased 40.82 9.99 357 267571 229033 110092338
Anorgasmia 40.73 9.99 33 267895 1613 110319758
Toxicologic test abnormal 40.63 9.99 30 267898 1277 110320094
Antipsychotic drug level increased 40.54 9.99 66 267862 6949 110314422
Electrocardiogram QRS complex shortened 40.30 9.99 25 267903 795 110320576
Middle insomnia 40.04 9.99 125 267803 20377 110300994
Anhedonia 39.81 9.99 104 267824 15324 110306047
Tachyphrenia 39.75 9.99 38 267890 2318 110319053
Mucosal inflammation 39.68 9.99 111 267817 96030 110225341
Haematotoxicity 39.58 9.99 3 267925 21079 110300292
Maternal exposure timing unspecified 39.42 9.99 3 267925 21010 110300361
Neutrophil count decreased 39.34 9.99 155 267773 120786 110200585
Foot deformity 38.90 9.99 36 267892 48444 110272927
Anaphylactic reaction 38.79 9.99 144 267784 114156 110207215
Self esteem decreased 38.70 9.99 27 267901 1050 110320321
Left ventricular dysfunction 38.53 9.99 135 267793 23358 110298013
Drug eruption 38.35 9.99 44 267884 53615 110267756
Dropped head syndrome 38.31 9.99 21 267907 527 110320844
Tinnitus 37.86 9.99 264 267664 60276 110261095
Rheumatoid nodule 37.79 9.99 3 267925 20293 110301078
Hereditary non-polyposis colorectal cancer syndrome 37.66 9.99 8 267920 3 110321368
Product used for unknown indication 37.64 9.99 34 267894 1929 110319442
Transplant rejection 37.54 9.99 7 267921 24560 110296811
Circulatory collapse 37.31 9.99 204 267724 42789 110278582
Feeling of despair 37.23 9.99 46 267882 3752 110317619
Drug screen false positive 37.20 9.99 29 267899 1340 110320031
Soft tissue injury 37.06 9.99 36 267892 2240 110319131
Reduced facial expression 37.05 9.99 45 267883 3606 110317765
Exostosis 37.02 9.99 34 267894 45922 110275449
Gastrointestinal haemorrhage 36.83 9.99 242 267686 165276 110156095
Derealisation 36.77 9.99 35 267893 2123 110319248
Respiratory failure 36.62 9.99 339 267589 214993 110106378
Swelling face 36.48 9.99 363 267565 91958 110229413
Catatonia 36.44 9.99 83 267845 11217 110310154
Hyperthermia 36.42 9.99 124 267804 21148 110300223
Skin candida 36.37 9.99 36 267892 2292 110319079
Unresponsive to stimuli 36.34 9.99 272 267656 63518 110257853
Iodine allergy 36.05 9.99 22 267906 679 110320692
Victim of sexual abuse 35.88 9.99 20 267908 519 110320852
Medication overuse headache 35.88 9.99 30 267898 1533 110319838
Increased appetite 35.66 9.99 98 267830 14879 110306492
Immunodeficiency 35.54 9.99 187 267741 38651 110282720
Narcolepsy 35.46 9.99 30 267898 1558 110319813
Finger deformity 35.29 9.99 18 267910 33074 110288297
Akinesia 35.28 9.99 44 267884 3623 110317748
Product tampering 35.28 9.99 19 267909 460 110320911
Fear 35.24 9.99 130 267798 23063 110298308
Tubulointerstitial nephritis 35.15 9.99 48 267880 54236 110267135
Illusion 35.06 9.99 33 267895 1974 110319397
Testicular atrophy 34.89 9.99 18 267910 398 110320973
Palmar-plantar erythrodysaesthesia syndrome 34.68 9.99 29 267899 40996 110280375
Amniorrhexis 34.66 9.99 10 267918 38 110321333
Metabolic syndrome 34.56 9.99 41 267887 3206 110318165
Amenorrhoea 34.55 9.99 72 267856 9159 110312212
Negative thoughts 34.53 9.99 30 267898 1616 110319755
Acute respiratory distress syndrome 34.46 9.99 234 267694 52964 110268407
Product residue present 34.32 9.99 45 267883 3896 110317475
Oscillopsia 34.25 9.99 18 267910 414 110320957
Epstein-Barr virus infection 34.25 9.99 3 267925 18735 110302636
Full blood count abnormal 34.22 9.99 243 267685 55809 110265562
Therapeutic response unexpected 34.04 9.99 131 267797 23712 110297659
Nephropathy toxic 34.02 9.99 12 267916 27466 110293905
Tumour lysis syndrome 33.99 9.99 16 267912 30785 110290586
Left ventricular hypertrophy 33.89 9.99 89 267839 13155 110308216
Prostate cancer 33.85 9.99 25 267903 37616 110283755
Eosinophilic pleural effusion 33.55 9.99 19 267909 509 110320862
Poor quality sleep 33.54 9.99 146 267782 27931 110293440
Laryngitis 33.43 9.99 32 267896 42379 110278992
Adrenal insufficiency 33.40 9.99 32 267896 42358 110279013
Hepatic function abnormal 33.33 9.99 108 267820 89187 110232184
Dependence 33.33 9.99 37 267891 2692 110318679
Hepatic necrosis 33.25 9.99 74 267854 9848 110311523
Skin necrosis 33.15 9.99 6 267922 21506 110299865
Aplastic anaemia 32.99 9.99 9 267919 24299 110297072
Binge eating 32.98 9.99 20 267908 610 110320761
Sleep paralysis 32.96 9.99 23 267905 895 110320476
Plasma cell myeloma 32.93 9.99 64 267864 62872 110258499
Mutism 32.62 9.99 39 267889 3074 110318297
Hypoglycaemia 32.56 9.99 427 267501 115677 110205694
Multiple sclerosis 32.53 9.99 136 267792 25562 110295809
Cardiomyopathy 32.47 9.99 164 267764 33361 110288010
Radiation inflammation 32.45 9.99 24 267904 1024 110320347
Affective disorder 32.37 9.99 79 267849 11162 110310209
Psychiatric symptom 32.33 9.99 70 267858 9143 110312228
Substance use disorder 32.27 9.99 61 267867 7229 110314142
Incoherent 32.24 9.99 66 267862 8292 110313079
Acute myeloid leukaemia 32.14 9.99 27 267901 38083 110283288
Phagophobia 32.13 9.99 10 267918 52 110321319
Feeling drunk 32.13 9.99 52 267876 5448 110315923
Spasmodic dysphonia 32.04 9.99 19 267909 556 110320815
Adjustment disorder with mixed anxiety and depressed mood 31.82 9.99 12 267916 120 110321251
Persistent genital arousal disorder 31.69 9.99 20 267908 656 110320715
Brain death 31.61 9.99 57 267871 6516 110314855
Hyperkalaemia 31.52 9.99 196 267732 135600 110185771
Drug abuser 31.41 9.99 51 267877 5358 110316013
Acute kidney injury 31.39 9.99 1240 266688 634190 109687181
Sleep apnoea syndrome 31.21 9.99 186 267742 40261 110281110
Duplicate therapy error 31.18 9.99 17 267911 422 110320949
Anuria 30.96 9.99 129 267799 24212 110297159
Ear infection 30.95 9.99 66 267862 62666 110258705
Asphyxia 30.90 9.99 90 267838 14125 110307246
Decreased interest 30.87 9.99 48 267880 4860 110316511
No adverse event 30.66 9.99 85 267843 73754 110247617
Haemoptysis 30.48 9.99 81 267847 71273 110250098
Paradoxical drug reaction 30.44 9.99 71 267857 9746 110311625
Decreased appetite 30.38 9.99 899 267029 474947 109846424
Bradykinesia 30.20 9.99 75 267853 10713 110310658
Postmortem blood drug level abnormal 30.16 9.99 19 267909 621 110320750
Head injury 30.16 9.99 193 267735 42824 110278547
Endolymphatic hydrops 30.15 9.99 6 267922 0 110321371
Muscular weakness 30.14 9.99 422 267506 248046 110073325
Ischaemic hepatitis 30.00 9.99 46 267882 4602 110316769
Myelodysplastic syndrome 29.88 9.99 28 267900 37456 110283915
Eye movement disorder 29.77 9.99 70 267858 9658 110311713
Tonic convulsion 29.76 9.99 37 267891 3037 110318334
Kleptomania 29.68 9.99 8 267920 22 110321349
Muscle mass 29.66 9.99 17 267911 466 110320905
Angioedema 29.63 9.99 367 267561 98133 110223238
Potentiating drug interaction 29.55 9.99 78 267850 11565 110309806
Cytomegalovirus viraemia 29.54 9.99 4 267924 17760 110303611
Pressure of speech 29.41 9.99 25 267903 1307 110320064
Pathogen resistance 29.34 9.99 4 267924 17668 110303703
Colitis ulcerative 29.27 9.99 93 267835 77270 110244101
HELLP syndrome 29.26 9.99 21 267907 855 110320516
Ejaculation disorder 29.20 9.99 18 267910 566 110320805
Cerebral haematoma 29.14 9.99 69 267859 9563 110311808
COVID-19 29.09 9.99 418 267510 244642 110076729
Frequent bowel movements 29.03 9.99 83 267845 71307 110250064
Gambling disorder 29.02 9.99 31 267897 2160 110319211
Hypokinesia 28.81 9.99 117 267811 21709 110299662
Clinomania 28.69 9.99 10 267918 78 110321293
Back injury 28.64 9.99 44 267884 47355 110274016
Neoplasm progression 28.61 9.99 72 267856 64523 110256848
Bradypnoea 28.42 9.99 64 267864 8585 110312786
Thrombosis 28.35 9.99 151 267777 108511 110212860
Emotional poverty 28.19 9.99 22 267906 1018 110320353
COVID-19 pneumonia 28.16 9.99 29 267899 37114 110284257
Distributive shock 28.14 9.99 51 267877 5853 110315518
Yawning 28.11 9.99 26 267902 1521 110319850
Renal papillary necrosis 28.10 9.99 16 267912 433 110320938
Loose associations 28.05 9.99 10 267918 84 110321287
Post-traumatic neck syndrome 28.00 9.99 33 267895 2562 110318809
Blood pressure increased 27.99 9.99 822 267106 257551 110063820
Slow response to stimuli 27.88 9.99 29 267899 1959 110319412
Activation syndrome 27.78 9.99 15 267913 365 110321006
Post-traumatic stress disorder 27.74 9.99 54 267874 6542 110314829
Helplessness 27.71 9.99 15 267913 367 110321004
Unemployment 27.71 9.99 9 267919 55 110321316
Psoriasis 27.67 9.99 485 267443 139508 110181863
Respiratory acidosis 27.65 9.99 85 267843 13741 110307630
Respiratory disorder 27.58 9.99 85 267843 71297 110250074
Psychomotor skills impaired 27.54 9.99 56 267872 7002 110314369
Depersonalisation/derealisation disorder 27.38 9.99 30 267898 2151 110319220
Contusion 27.36 9.99 399 267529 232962 110088409
Burnout syndrome 27.20 9.99 15 267913 381 110320990
Thermophobia 27.17 9.99 9 267919 59 110321312
Respiratory tract infection 27.16 9.99 86 267842 71531 110249840
Parasomnia 26.94 9.99 19 267909 752 110320619
Bacteraemia 26.93 9.99 38 267890 42352 110279019
Pre-existing condition improved 26.92 9.99 53 267875 6473 110314898
Anal incontinence 26.84 9.99 115 267813 21849 110299522
Pulse abnormal 26.69 9.99 41 267887 4108 110317263
Personality disorder 26.69 9.99 80 267848 12757 110308614
Macrophages increased 26.65 9.99 13 267915 254 110321117
Torsade de pointes 26.60 9.99 117 267811 22483 110298888
Hypercalcaemia 26.60 9.99 45 267883 46612 110274759
Emotional distress 26.55 9.99 193 267735 44654 110276717
Retching 26.38 9.99 117 267811 22565 110298806
Arrhythmia 26.26 9.99 271 267657 69304 110252067
Status epilepticus 26.19 9.99 148 267780 31423 110289948
Generalised anxiety disorder 26.19 9.99 33 267895 2746 110318625
Sternal fracture 26.03 9.99 36 267892 3280 110318091
Cogwheel rigidity 25.87 9.99 38 267890 3660 110317711
Amniotic fluid volume increased 25.86 9.99 11 267917 154 110321217
Frustration tolerance decreased 25.83 9.99 62 267866 8669 110312702
Myasthenia gravis 25.61 9.99 10 267918 21501 110299870
Diffuse large B-cell lymphoma 25.46 9.99 4 267924 15894 110305477
Cough 25.43 9.99 889 267039 460752 109860619
ECG P wave inverted 25.13 9.99 5 267923 0 110321371
Infusion site reaction 25.05 9.99 6 267922 17676 110303695
Right ventricular failure 24.99 9.99 16 267912 25938 110295433
Dystonia 24.83 9.99 126 267802 25679 110295692
Tongue biting 24.73 9.99 33 267895 2906 110318465
Schizophreniform disorder 24.54 9.99 11 267917 176 110321195
Cataract 24.51 9.99 104 267824 79381 110241990
Neurodegenerative disorder 24.32 9.99 18 267910 769 110320602
Attention deficit hyperactivity disorder 24.27 9.99 41 267887 4450 110316921
Interstitial lung disease 24.27 9.99 218 267710 139116 110182255
False positive investigation result 24.22 9.99 23 267905 1391 110319980
Prescribed underdose 24.20 9.99 79 267849 65095 110256276
Palpitations 24.17 9.99 530 267398 158682 110162689
Nodule 24.15 9.99 26 267902 32605 110288766
Tenosynovitis 24.12 9.99 5 267923 16278 110305093
Ventricular dysfunction 24.03 9.99 55 267873 7456 110313915
Onychomycosis 24.02 9.99 35 267893 38496 110282875
Respiratory tract inflammation 23.90 9.99 20 267908 1023 110320348
Obsessive thoughts 23.81 9.99 22 267906 1285 110320086
Pneumonitis 23.69 9.99 100 267828 76431 110244940
Injection site reaction 23.67 9.99 123 267805 88947 110232424
Muscle tightness 23.49 9.99 84 267844 14678 110306693
Chronic sinusitis 23.42 9.99 16 267912 25068 110296303
Otospondylomegaepiphyseal dysplasia 23.41 9.99 7 267921 31 110321340
Coma acidotic 23.32 9.99 10 267918 143 110321228
External auditory canal atresia 23.27 9.99 6 267922 13 110321358
Merycism 23.16 9.99 13 267915 342 110321029
Angle closure glaucoma 23.11 9.99 35 267893 3464 110317907
Trismus 23.02 9.99 50 267878 6546 110314825
Iris coloboma 22.96 9.99 6 267922 14 110321357
Retinal coloboma 22.96 9.99 6 267922 14 110321357
Protein S decreased 22.95 9.99 10 267918 149 110321222
Neurotoxicity 22.89 9.99 42 267886 42165 110279206
Megacolon 22.87 9.99 39 267889 4266 110317105
Alcohol use 22.77 9.99 38 267890 4084 110317287
Alcohol abuse 22.76 9.99 42 267886 4887 110316484
Salivary hypersecretion 22.68 9.99 93 267835 17328 110304043
Spontaneous ejaculation 22.67 9.99 6 267922 15 110321356
Regressive behaviour 22.60 9.99 11 267917 214 110321157
Hypervigilance 22.52 9.99 16 267912 641 110320730
Osteonecrosis of jaw 22.47 9.99 52 267876 47965 110273406
Disability 22.46 9.99 24 267904 30199 110291172
Haematuria 22.41 9.99 114 267814 82891 110238480
Respiratory tract congestion 22.38 9.99 25 267903 30832 110290539
Coeliac disease 22.30 9.99 180 267748 43007 110278364
Gangrene 22.27 9.99 6 267922 16335 110305036
Vasoplegia syndrome 22.23 9.99 44 267884 5395 110315976
Cold sweat 22.21 9.99 109 267819 21922 110299449
Pericardial effusion 22.20 9.99 68 267860 57149 110264222
Impulse-control disorder 22.20 9.99 27 267901 2167 110319204
Second primary malignancy 22.18 9.99 8 267920 18060 110303311
Depression suicidal 22.15 9.99 41 267887 4783 110316588
Walking aid user 22.10 9.99 17 267911 25058 110296313
Ventricular arrhythmia 22.06 9.99 64 267864 10023 110311348
Nausea 22.03 9.99 3362 264566 1232328 109089043
Decreased immune responsiveness 22.03 9.99 62 267866 9544 110311827
Graft versus host disease 21.97 9.99 9 267919 18797 110302574
Road traffic accident 21.93 9.99 161 267767 107237 110214134
Male orgasmic disorder 21.86 9.99 8 267920 73 110321298
Normal newborn 21.77 9.99 13 267915 21883 110299488
Allergy to venom 21.67 9.99 5 267923 5 110321366
Pneumonia bacterial 21.67 9.99 19 267909 26242 110295129
Creatinine renal clearance decreased 21.62 9.99 13 267915 21802 110299569
Flight of ideas 21.56 9.99 17 267911 799 110320572
Acute myocardial infarction 21.53 9.99 117 267811 83660 110237711
Renal cancer 21.52 9.99 3 267925 13031 110308340
Extrasystoles 21.39 9.99 56 267872 8262 110313109
External ear disorder 21.30 9.99 8 267920 79 110321292
Encephalopathy 21.04 9.99 294 267634 80761 110240610
Incontinence 21.03 9.99 88 267840 16547 110304824
Hypertensive heart disease 21.02 9.99 39 267889 4557 110316814
Constipation 20.97 9.99 1064 266864 356722 109964649
Herbal interaction 20.89 9.99 15 267913 611 110320760
Kidney duplex 20.75 9.99 6 267922 23 110321348
Erythema dyschromicum perstans 20.70 9.99 8 267920 86 110321285
Sciatic nerve neuropathy 20.66 9.99 14 267914 519 110320852
Ventricular hypokinesia 20.65 9.99 67 267861 11147 110310224
Antisocial behaviour 20.63 9.99 17 267911 851 110320520
Trunk injury 20.55 9.99 6 267922 24 110321347
Exposure via ingestion 20.46 9.99 40 267888 4860 110316511
Chest discomfort 20.46 9.99 297 267631 173551 110147820
International normalised ratio increased 20.26 9.99 125 267803 86647 110234724
Pneumothorax 20.14 9.99 34 267894 35251 110286120
Blood urea increased 20.14 9.99 67 267861 54890 110266481
Metastases to bone 20.05 9.99 28 267900 31344 110290027
Haemolytic anaemia 20.00 9.99 13 267915 20907 110300464
Abnormal sleep-related event 20.00 9.99 17 267911 889 110320482
Proctitis 19.94 9.99 8 267920 16919 110304452
Splenomegaly 19.88 9.99 18 267910 24480 110296891
Ataxia 19.84 9.99 133 267795 29975 110291396
Prescribed overdose 19.73 9.99 310 267618 87271 110234100
Cystitis haemorrhagic 19.72 9.99 3 267925 12206 110309165
Abnormal weight gain 19.70 9.99 33 267895 3558 110317813
Acidosis 19.61 9.99 107 267821 22424 110298947
Multiple sclerosis relapse 19.58 9.99 197 267731 50043 110271328
Photophobia 19.55 9.99 118 267810 25653 110295718
Rash pruritic 19.55 9.99 148 267780 97921 110223450
Joint stiffness 19.52 9.99 90 267838 67153 110254218
Sluggishness 19.52 9.99 51 267877 7516 110313855
Status migrainosus 19.48 9.99 8 267920 102 110321269
Metastases to central nervous system 19.45 9.99 16 267912 22801 110298570
Adverse reaction 19.33 9.99 26 267902 29568 110291803
Perinatal depression 19.30 9.99 13 267915 477 110320894
Eye pruritus 19.25 9.99 31 267897 32744 110288627
Blood lactate dehydrogenase increased 19.18 9.99 50 267878 44284 110277087
Skin ulcer 19.18 9.99 84 267844 63561 110257810
Pneumonia fungal 19.04 9.99 6 267922 14748 110306623
Device difficult to use 18.93 9.99 11 267917 18794 110302577
Blood immunoglobulin E increased 18.86 9.99 50 267878 7432 110313939
Priapism 18.85 9.99 43 267885 5818 110315553
Schizoaffective disorder 18.80 9.99 30 267898 3106 110318265
Parkinsonism hyperpyrexia syndrome 18.79 9.99 14 267914 604 110320767
Ejection fraction decreased 18.78 9.99 166 267762 40714 110280657
Therapy non-responder 18.77 9.99 268 267660 157039 110164332
Phaeochromocytoma malignant 18.74 9.99 7 267921 68 110321303
Bipolar II disorder 18.74 9.99 13 267915 501 110320870
Escherichia infection 18.74 9.99 18 267910 23798 110297573
Blood lactic acid increased 18.69 9.99 82 267846 15739 110305632
Leukopenia 18.65 9.99 251 267677 148540 110172831
Pulmonary alveolar haemorrhage 18.62 9.99 13 267915 20137 110301234
Appendicitis 18.60 9.99 25 267903 28439 110292932
Bursitis 18.60 9.99 213 267715 129705 110191666
Impaired driving ability 18.59 9.99 45 267883 6325 110315046
Claustrophobia 18.59 9.99 21 267907 1558 110319813
Compulsive shopping 18.57 9.99 16 267912 852 110320519
Transient psychosis 18.56 9.99 7 267921 70 110321301
CYP3A4 polymorphism 18.56 9.99 7 267921 70 110321301
Delirium 18.48 9.99 443 267485 134582 110186789
Cerebellar haematoma 18.47 9.99 14 267914 620 110320751
Ulcer 18.37 9.99 49 267879 43067 110278304
Foaming at mouth 18.36 9.99 25 267903 2245 110319126
Blood ethanol increased 18.34 9.99 14 267914 627 110320744
Amnesia 18.33 9.99 358 267570 105050 110216321
Asthenia 18.29 9.99 1429 266499 687570 109633801
Oesophageal carcinoma 18.23 9.99 3 267925 11521 110309850
Hyperchloraemia 18.22 9.99 19 267909 1287 110320084
Enthesopathy 18.14 9.99 4 267924 12474 110308897
Rectal haemorrhage 18.13 9.99 194 267734 119639 110201732
Transfusion 18.08 9.99 21 267907 25451 110295920
Stillbirth 18.04 9.99 35 267893 4229 110317142
Micturition disorder 18.00 9.99 37 267891 4661 110316710
Hypotension 17.96 9.99 1488 266440 522361 109799010
Orthostatic intolerance 17.95 9.99 24 267904 2117 110319254
Flat affect 17.90 9.99 26 267902 2479 110318892
Polyarthritis 17.84 9.99 12 267916 18951 110302420
Ulcer haemorrhage 17.82 9.99 17 267911 22554 110298817
Toxic cardiomyopathy 17.81 9.99 15 267913 774 110320597
Thrombotic microangiopathy 17.66 9.99 27 267901 29122 110292249
Pseudomonas infection 17.66 9.99 25 267903 27828 110293543
Ejaculation delayed 17.65 9.99 9 267919 194 110321177
Food craving 17.64 9.99 23 267905 1980 110319391
Device related infection 17.54 9.99 44 267884 39475 110281896
Acquired amegakaryocytic thrombocytopenia 17.54 9.99 6 267922 44 110321327
Female sexual dysfunction 17.54 9.99 6 267922 44 110321327
Confusion postoperative 17.53 9.99 11 267917 357 110321014
Vitamin K decreased 17.50 9.99 7 267921 83 110321288
Vasculitis 17.48 9.99 38 267890 35835 110285536
Macular degeneration 17.47 9.99 16 267912 21643 110299728
Disinhibition 17.46 9.99 29 267899 3105 110318266
Treatment noncompliance 17.46 9.99 261 267667 72729 110248642
Gambling 17.42 9.99 11 267917 361 110321010
Sensory disturbance 17.40 9.99 86 267842 17343 110304028
Feeling guilty 17.38 9.99 16 267912 930 110320441
Stress 17.38 9.99 355 267573 104993 110216378
Therapeutic product effect incomplete 17.37 9.99 411 267517 223394 110097977
Hyperacusis 17.37 9.99 28 267900 2924 110318447
Hyperphosphataemia 17.33 9.99 9 267919 16372 110304999
Productive cough 17.32 9.99 185 267743 114120 110207251
Purging 17.31 9.99 6 267922 46 110321325
Aspergillus infection 17.25 9.99 22 267906 25594 110295777
Peak expiratory flow rate decreased 17.25 9.99 14 267914 686 110320685
Blood catecholamines increased 17.21 9.99 7 267921 87 110321284
Product use issue 17.20 9.99 600 267328 311095 110010276
Orgasmic sensation decreased 17.19 9.99 6 267922 47 110321324
Genital hypoaesthesia 17.17 9.99 9 267919 206 110321165
End stage renal disease 17.16 9.99 16 267912 21457 110299914
Histamine level increased 17.15 9.99 8 267920 141 110321230
Exposure during pregnancy 17.14 9.99 529 267399 166895 110154476
Normal pressure hydrocephalus 17.13 9.99 13 267915 577 110320794
Renal disorder 17.00 9.99 62 267866 49417 110271954
Pulmonary mass 16.97 9.99 41 267887 37260 110284111
Bladder dilatation 16.97 9.99 25 267903 2414 110318957
Hyperventilation 16.97 9.99 54 267874 8893 110312478
Anticonvulsant drug level above therapeutic 16.97 9.99 18 267910 1244 110320127
Drug level above therapeutic 16.81 9.99 64 267864 11524 110309847
Hypoxia 16.77 9.99 217 267711 129298 110192073
Cold agglutinins positive 16.77 9.99 6 267922 51 110321320
Platelet aggregation abnormal 16.77 9.99 6 267922 51 110321320
Ventricular extrasystoles 16.76 9.99 103 267825 22538 110298833
Humidity intolerance 16.73 9.99 12 267916 488 110320883
Heat stroke 16.70 9.99 22 267906 1913 110319458
Abdominal distension 16.69 9.99 311 267617 174792 110146579
Laboratory test abnormal 16.67 9.99 53 267875 44026 110277345
Blood calcium decreased 16.63 9.99 39 267889 35806 110285565
Adulterated product 16.47 9.99 17 267911 1138 110320233
Tic 16.43 9.99 30 267898 3463 110317908
Blood potassium increased 16.38 9.99 35 267893 33214 110288157
Long QT syndrome 16.38 9.99 46 267882 7072 110314299
Eosinophilic pustular folliculitis 16.37 9.99 8 267920 157 110321214
Imprisonment 16.26 9.99 14 267914 745 110320626
Delusional disorder, unspecified type 16.24 9.99 15 267913 876 110320495
Exposure via transplant 16.23 9.99 5 267923 25 110321346
Myocardial fibrosis 16.18 9.99 22 267906 1973 110319398
Food aversion 16.15 9.99 20 267908 1635 110319736
Photopsia 16.15 9.99 42 267886 6172 110315199
Dry mouth 16.13 9.99 365 267563 199583 110121788
Respiratory symptom 16.13 9.99 8 267920 14937 110306434
Inadequate analgesia 16.05 9.99 37 267891 5040 110316331
Blood triglycerides increased 15.95 9.99 106 267822 23820 110297551
Haemophagocytic lymphohistiocytosis 15.73 9.99 33 267895 31526 110289845
Implant site extravasation 15.72 9.99 15 267913 913 110320458
Dysphemia 15.71 9.99 32 267896 4005 110317366
Aortic stenosis 15.66 9.99 6 267922 13053 110308318
Pregnancy 15.63 9.99 67 267861 51000 110270371
Pupil fixed 15.63 9.99 31 267897 3807 110317564
Focal dyscognitive seizures 15.57 9.99 31 267897 3818 110317553
Arachnoid cyst 15.52 9.99 11 267917 439 110320932
Peritonitis 15.51 9.99 35 267893 32572 110288799
Tricuspid valve sclerosis 15.47 9.99 5 267923 30 110321341
Pleuritic pain 15.47 9.99 10 267918 16130 110305241
Slow speech 15.45 9.99 29 267899 3419 110317952
Restless arm syndrome 15.40 9.99 6 267922 66 110321305
Acute hepatitis B 15.38 9.99 12 267916 555 110320816
Pulmonary contusion 15.38 9.99 8 267920 180 110321191
Drug dose omission by device 15.32 9.99 8 267920 14508 110306863
Bipolar I disorder 15.31 9.99 23 267905 2260 110319111
Hypoaesthesia 15.31 9.99 614 267314 313609 110007762
Violence-related symptom 15.30 9.99 15 267913 944 110320427
Kidney transplant rejection 15.25 9.99 5 267923 11982 110309389
Ankle fracture 15.20 9.99 91 267837 19728 110301643
Dysstasia 15.18 9.99 134 267794 32852 110288519
Grandiosity 15.16 9.99 12 267916 567 110320804
Catecholamines urine increased 15.07 9.99 5 267923 33 110321338
Substance use 15.06 9.99 24 267904 2482 110318889
Barotrauma 14.99 9.99 8 267920 190 110321181
Indifference 14.94 9.99 10 267918 363 110321008
Substance abuser 14.94 9.99 11 267917 466 110320905
Therapy interrupted 14.87 9.99 66 267862 49756 110271615
Tympanic membrane disorder 14.81 9.99 8 267920 195 110321176
Snoring 14.79 9.99 43 267885 6741 110314630
Urinary hesitation 14.78 9.99 34 267894 4624 110316747
Hepatitis 14.78 9.99 143 267785 89911 110231460
Dyspnoea exertional 14.74 9.99 171 267757 103889 110217482
Squamous cell carcinoma of skin 14.74 9.99 12 267916 17191 110304180
Fear-related avoidance of activities 14.72 9.99 7 267921 129 110321242
Conversion disorder 14.66 9.99 23 267905 2347 110319024
Herpes zoster 14.62 9.99 180 267748 108199 110213172
Skull fractured base 14.49 9.99 10 267918 382 110320989
Hepatic cirrhosis 14.48 9.99 100 267828 67526 110253845
Rib fracture 14.43 9.99 135 267793 33635 110287736
Cerebral vasoconstriction 14.43 9.99 18 267910 1483 110319888
Drug ineffective 14.40 9.99 4012 263916 1516528 108804843
Anaphylactic shock 14.37 9.99 70 267858 51476 110269895
Lip and/or oral cavity cancer 14.30 9.99 16 267912 1174 110320197
Craniocerebral injury 14.30 9.99 39 267889 5895 110315476
Device malfunction 14.25 9.99 25 267903 25533 110295838
Sinus rhythm 14.24 9.99 15 267913 1028 110320343
Cellulitis 14.23 9.99 217 267711 125799 110195572
Renal failure 14.20 9.99 429 267499 226145 110095226
Migraine 14.18 9.99 529 267399 171123 110150248
Disturbance in sexual arousal 14.18 9.99 10 267918 396 110320975
Aplasia pure red cell 14.07 9.99 3 267925 9575 110311796
Aspartate aminotransferase increased 14.05 9.99 288 267640 159648 110161723
Full blood count decreased 14.04 9.99 36 267892 32063 110289308
Breath sounds abnormal 14.03 9.99 25 267903 25379 110295992
Cardiac failure chronic 14.01 9.99 8 267920 13803 110307568
Sickle cell anaemia with crisis 14.00 9.99 3 267925 9542 110311829
Drug diversion 13.99 9.99 17 267911 1363 110320008
Upper gastrointestinal haemorrhage 13.98 9.99 68 267860 50028 110271343
Withdrawal catatonia 13.93 9.99 10 267918 407 110320964
Affect lability 13.93 9.99 85 267843 18552 110302819
Parkinsonian gait 13.90 9.99 15 267913 1057 110320314
Partner stress 13.89 9.99 9 267919 309 110321062
Pulmonary arterial hypertension 13.89 9.99 37 267891 32531 110288840
Disorganised speech 13.84 9.99 27 267901 3276 110318095
Staring 13.81 9.99 25 267903 2867 110318504
Chronic idiopathic pain syndrome 13.81 9.99 8 267920 224 110321147
Behaviour disorder 13.77 9.99 53 267875 9594 110311777
Device occlusion 13.76 9.99 10 267918 15175 110306196
Executive dysfunction 13.76 9.99 10 267918 415 110320956
Personality change 13.75 9.99 58 267870 10944 110310427
Bladder trabeculation 13.73 9.99 6 267922 90 110321281
Opiates positive 13.72 9.99 14 267914 925 110320446
Selective mutism 13.68 9.99 6 267922 91 110321280
Accident at work 13.66 9.99 16 267912 1234 110320137
Ocular hyperaemia 13.65 9.99 49 267879 39237 110282134
Melaena 13.59 9.99 104 267824 68653 110252718
Rash erythematous 13.58 9.99 276 267652 81556 110239815
Gastrointestinal toxicity 13.58 9.99 5 267923 11143 110310228
Vascular device infection 13.56 9.99 12 267916 16500 110304871
Apallic syndrome 13.52 9.99 15 267913 1091 110320280
Skin texture abnormal 13.48 9.99 11 267917 543 110320828
Painful erection 13.46 9.99 8 267920 235 110321136
Gun shot wound 13.45 9.99 15 267913 1097 110320274
Starvation ketoacidosis 13.39 9.99 9 267919 329 110321042
Gastric infection 13.39 9.99 31 267897 4235 110317136
Hypertensive crisis 13.36 9.99 103 267825 24269 110297102
Limited symptom panic attack 13.35 9.99 5 267923 49 110321322
Skin disorder 13.32 9.99 56 267872 42857 110278514
Immunosuppression 13.31 9.99 14 267914 17745 110303626
Alanine aminotransferase increased 13.30 9.99 341 267587 183432 110137939
Polydipsia psychogenic 13.30 9.99 9 267919 333 110321038
Phonophobia 13.28 9.99 12 267916 681 110320690
Feeling of body temperature change 13.28 9.99 39 267889 6149 110315222
Hypotonia 13.18 9.99 74 267854 15671 110305700
Musculoskeletal chest pain 13.18 9.99 117 267811 28730 110292641
Ligament pain 13.14 9.99 8 267920 246 110321125
Dysuria 13.11 9.99 212 267716 60019 110261352
Rales 13.08 9.99 25 267903 24714 110296657
Immune effector cell-associated neurotoxicity syndrome 13.06 9.99 10 267918 14772 110306599
Cartilage injury 13.05 9.99 18 267910 1636 110319735
Respiratory rate decreased 13.01 9.99 39 267889 6219 110315152
Paraesthesia 13.00 9.99 806 267122 275715 110045656
Schizophrenia 12.96 9.99 94 267834 21732 110299639
Self-destructive behaviour 12.95 9.99 13 267915 842 110320529
Loose tooth 12.92 9.99 26 267902 3227 110318144
Victim of homicide 12.88 9.99 8 267920 255 110321116
Phlebolith 12.87 9.99 7 267921 173 110321198
Judgement impaired 12.86 9.99 16 267912 1314 110320057
Genital anaesthesia 12.82 9.99 4 267924 21 110321350
Poverty of speech 12.70 9.99 11 267917 590 110320781
Colitis ischaemic 12.67 9.99 80 267848 17670 110303701
Anaemia of pregnancy 12.65 9.99 6 267922 110 110321261
Dreamy state 12.60 9.99 5 267923 58 110321313
Proteinuria 12.56 9.99 52 267876 39966 110281405
Respiratory syncytial virus infection 12.54 9.99 10 267918 14474 110306897
Body temperature abnormal 12.53 9.99 25 267903 3084 110318287
Bundle branch block right 12.52 9.99 61 267867 12230 110309141
Blood test abnormal 12.51 9.99 32 267896 28522 110292849
Radius fracture 12.48 9.99 29 267899 3971 110317400
Metastases to lung 12.46 9.99 23 267905 23040 110298331
Heavy menstrual bleeding 12.46 9.99 75 267853 16290 110305081
Vaginal discharge 12.46 9.99 15 267913 17893 110303478
Skin exfoliation 12.43 9.99 144 267784 87507 110233864
Poor personal hygiene 12.42 9.99 11 267917 608 110320763
Hypocalcaemia 12.40 9.99 100 267828 65266 110256105
Morbihan disease 12.38 9.99 4 267924 24 110321347
Joint dislocation 12.31 9.99 42 267886 34148 110287223
Ideas of reference 12.31 9.99 7 267921 189 110321182
Carotid artery thrombosis 12.29 9.99 4 267924 9634 110311737
Dry skin 12.29 9.99 185 267743 107468 110213903
Pustular psoriasis 12.28 9.99 9 267919 13596 110307775
Third stage postpartum haemorrhage 12.24 9.99 4 267924 25 110321346
Hyperinsulinaemia 12.24 9.99 8 267920 279 110321092
Hypertrophic cardiomyopathy 12.23 9.99 25 267903 3138 110318233
Chest pain 12.21 9.99 767 267161 375608 109945763
Delusional disorder, persecutory type 12.19 9.99 11 267917 623 110320748
Blood phosphorus increased 12.11 9.99 13 267915 16327 110305044
Cardiac failure congestive 12.08 9.99 276 267652 150724 110170647
Dialysis 12.06 9.99 18 267910 19601 110301770
Facial nerve disorder 12.05 9.99 12 267916 770 110320601
Knee arthroplasty 12.03 9.99 100 267828 64848 110256523
Pleural rub 12.02 9.99 5 267923 66 110321305
Hyponatraemic coma 12.02 9.99 5 267923 66 110321305
Memory impairment 12.01 9.99 588 267340 196356 110125015
Conjunctivitis viral 11.99 9.99 8 267920 289 110321082
Basilar artery occlusion 11.92 9.99 8 267920 292 110321079
Sleep talking 11.86 9.99 15 267913 1253 110320118
Amaurosis fugax 11.85 9.99 21 267907 2369 110319002
Chorea 11.84 9.99 25 267903 3210 110318161
Consciousness fluctuating 11.81 9.99 20 267908 2176 110319195
Abnormal uterine bleeding 11.80 9.99 16 267912 1431 110319940
Pseudophaeochromocytoma 11.78 9.99 6 267922 129 110321242
Eczema 11.77 9.99 115 267813 72178 110249193
Marital problem 11.77 9.99 7 267921 206 110321165
Injection site erythema 11.75 9.99 159 267769 94017 110227354
Pulmonary vein occlusion 11.74 9.99 6 267922 130 110321241
Hypernatriuria 11.73 9.99 4 267924 29 110321342
Increased tendency to bruise 11.73 9.99 58 267870 11700 110309671
Drug specific antibody 11.71 9.99 23 267905 2805 110318566
Myopathy 11.70 9.99 27 267901 24933 110296438
Hepatic cytolysis 11.70 9.99 193 267735 54860 110266511
Juvenile myoclonic epilepsy 11.69 9.99 5 267923 71 110321300
Localised infection 11.69 9.99 59 267869 42989 110278382
Device leakage 11.64 9.99 13 267915 16035 110305336
Bone density decreased 11.63 9.99 13 267915 16029 110305342
Patella fracture 11.62 9.99 21 267907 2405 110318966
Tendonitis 11.61 9.99 29 267899 26054 110295317
Skin maceration 11.59 9.99 7 267921 212 110321159
Breast reconstruction 11.58 9.99 6 267922 134 110321237
Coagulation factor VII level decreased 11.53 9.99 7 267921 214 110321157
Wrong dose 11.52 9.99 22 267906 2627 110318744
Accidental overdose 11.49 9.99 183 267745 51651 110269720
Large intestine perforation 11.49 9.99 14 267914 16615 110304756
Drug withdrawal convulsions 11.48 9.99 21 267907 2428 110318943
Product administration interrupted 11.48 9.99 56 267872 11236 110310135
Labour complication 11.34 9.99 6 267922 140 110321231
Cardiac failure 11.33 9.99 357 267571 187269 110134102
Hypnagogic hallucination 11.30 9.99 7 267921 222 110321149
Product prescribing error 11.30 9.99 181 267747 51150 110270221
Procedural pain 11.30 9.99 46 267882 35519 110285852
Rash maculo-papular 11.29 9.99 120 267808 74102 110247269
Lumbar vertebral fracture 11.28 9.99 4 267924 9127 110312244
Postural orthostatic tachycardia syndrome 11.28 9.99 18 267910 1864 110319507
Obsessive-compulsive symptom 11.25 9.99 8 267920 321 110321050
Flashback 11.23 9.99 9 267919 433 110320938
Weight increased 11.21 9.99 1171 266757 418473 109902898
Hypokinetic dysarthria 11.18 9.99 4 267924 34 110321337
Orthostatic hypotension 11.18 9.99 224 267704 66025 110255346
Bladder cancer 11.18 9.99 20 267908 20272 110301099
Cholestasis 11.17 9.99 219 267709 64299 110257072
Joint effusion 11.16 9.99 21 267907 20884 110300487
Hepatocellular carcinoma 11.11 9.99 5 267923 9875 110311496
Stereotypy 11.09 9.99 13 267915 1004 110320367
Human chorionic gonadotropin positive 11.08 9.99 4 267924 35 110321336
Dermatillomania 11.03 9.99 8 267920 331 110321040
Tonic clonic movements 11.02 9.99 23 267905 2929 110318442
Creutzfeldt-Jakob disease 10.97 9.99 7 267921 234 110321137
Cystic lymphangioma 10.94 9.99 3 267925 9 110321362
Alcohol withdrawal syndrome 10.93 9.99 19 267909 2111 110319260
Cholestatic liver injury 10.92 9.99 41 267887 7335 110314036
CYP2D6 polymorphism 10.88 9.99 5 267923 85 110321286
Hypersexuality 10.87 9.99 18 267910 1922 110319449
Housebound 10.86 9.99 9 267919 454 110320917
Hyperdynamic left ventricle 10.85 9.99 10 267918 582 110320789
Atrioventricular block 10.85 9.99 15 267913 16862 110304509
Diastolic hypotension 10.84 9.99 8 267920 340 110321031
Haematocrit decreased 10.84 9.99 105 267823 66012 110255359
Pancreatic carcinoma 10.84 9.99 12 267916 14860 110306511
Peritonitis bacterial 10.83 9.99 6 267922 10527 110310844
Underdose 10.82 9.99 100 267828 63454 110257917
Alpha 2 globulin increased 10.79 9.99 6 267922 155 110321216
Micturition urgency 10.79 9.99 82 267846 19238 110302133
Norepinephrine increased 10.78 9.99 5 267923 87 110321284
Candida infection 10.77 9.99 70 267858 47939 110273432
Device issue 10.76 9.99 45 267883 34490 110286881
Action tremor 10.71 9.99 9 267919 463 110320908
Shock 10.71 9.99 186 267742 53402 110267969
Death 10.70 9.99 1507 266421 697362 109624009
Atrophic vulvovaginitis 10.69 9.99 15 267913 1385 110319986
Respiratory distress 10.68 9.99 230 267698 68644 110252727
Bile acid malabsorption 10.68 9.99 9 267919 465 110320906
Accidental exposure to product 10.68 9.99 74 267854 49934 110271437
Movement disorder 10.67 9.99 135 267793 36269 110285102
Aspiration 10.62 9.99 117 267811 30416 110290955
Multiple organ dysfunction syndrome 10.58 9.99 283 267645 151427 110169944
Palate injury 10.57 9.99 5 267923 91 110321280
Gastrointestinal bacterial infection 10.54 9.99 15 267913 1403 110319968
Bladder neck obstruction 10.52 9.99 5 267923 92 110321279
Salivary gland disorder 10.52 9.99 8 267920 356 110321015
Erythema 10.50 9.99 588 267340 290859 110030512
Lacrimation increased 10.49 9.99 39 267889 30911 110290460
Renal aplasia 10.49 9.99 6 267922 164 110321207
Postoperative delirium 10.48 9.99 12 267916 903 110320468
Arterial occlusive disease 10.46 9.99 13 267915 15295 110306076
Inhibitory drug interaction 10.45 9.99 31 267897 4916 110316455
Rabies 10.43 9.99 4 267924 42 110321329
Supraventricular extrasystoles 10.43 9.99 43 267885 8030 110313341
Dysgraphia 10.43 9.99 30 267898 4675 110316696
Hypotonia neonatal 10.43 9.99 5 267923 94 110321277
Prothrombin level decreased 10.42 9.99 17 267911 1793 110319578
Multiple-drug resistance 10.41 9.99 10 267918 13225 110308146
Electrocardiogram ST-T segment abnormal 10.41 9.99 12 267916 910 110320461
Enterococcal infection 10.40 9.99 21 267907 20345 110301026
Skin toxicity 10.37 9.99 8 267920 11775 110309596
Neurological examination abnormal 10.34 9.99 11 267917 763 110320608
Seronegative arthritis 10.32 9.99 10 267918 13167 110308204
Hyperuricaemia 10.29 9.99 12 267916 14519 110306852
Therapeutic response decreased 10.28 9.99 168 267760 96331 110225040
Prescription drug used without a prescription 10.27 9.99 33 267895 5463 110315908
Liver abscess 10.25 9.99 3 267925 7736 110313635
Burns second degree 10.24 9.99 3 267925 7730 110313641
Vertebral artery occlusion 10.23 9.99 9 267919 493 110320878
Ear haemorrhage 10.23 9.99 20 267908 2431 110318940
Sleep disorder due to a general medical condition 10.22 9.99 79 267849 52033 110269338
Cerebrovascular accident 10.22 9.99 348 267580 180936 110140435
Stevens-Johnson syndrome 10.21 9.99 69 267859 46832 110274539
Tongue discomfort 10.20 9.99 22 267906 2866 110318505
Deja vu 10.15 9.99 5 267923 100 110321271
Tanning 10.15 9.99 5 267923 100 110321271
Menstrual disorder 10.12 9.99 30 267898 4754 110316617
Breast cyst 10.10 9.99 15 267913 1459 110319912
Diverticulitis 10.10 9.99 82 267846 53440 110267931
Anxiety disorder 10.09 9.99 31 267897 5009 110316362
Language disorder 10.03 9.99 26 267902 3812 110317559
Cholangitis 10.02 9.99 15 267913 16320 110305051
Hypnopompic hallucination 10.01 9.99 5 267923 103 110321268

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Selective eating disorder 45.77 28.87 106 2850 1273 109724
Respiratory disorder neonatal 40.03 28.87 139 2817 2141 108856
Cyanosis neonatal 38.97 28.87 39 2917 201 110796
Premature baby 38.96 28.87 44 2912 4930 106067
Neonatal asphyxia 38.56 28.87 39 2917 204 110793
Floppy infant 36.12 28.87 31 2925 126 110871
Hypotonia neonatal 34.91 28.87 75 2881 850 110147

Pharmacologic Action:

SourceCodeDescription
ATC N06AX16 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D000068760 Serotonin and Noradrenaline Reuptake Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D049990 Membrane Transport Modulators
FDA EPC N0000175749 Serotonin and Norepinephrine Reuptake Inhibitor
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35640 adrenergic uptake inhibitor
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
CHEBI has role CHEBI:51039 dopamine uptake inhibitor
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:48407 antiparkinson drug

Related Drugs by ATC class:

N06AX Other antidepressants 28 drugs
agomelatinebifemelanebrexanolonebupropiondesvenlafaxinedextromethorphanduloxetineesketaminegepironelevomilnacipranmedifoxaminemianserin show all 28 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Social phobia indication 25501002 DOID:11257
Major depressive disorder indication 370143000
Panic disorder indication 371631005 DOID:594
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Menopausal flushing off-label use 198436008
Neuropathic pain off-label use 247398009
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Cirrhosis of liver contraindication 19943007 DOID:5082
Hyperthyroidism contraindication 34486009 DOID:7998
Upper gastrointestinal hemorrhage contraindication 37372002
Hypertensive disorder contraindication 38341003 DOID:10763
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Substance abuse contraindication 66214007
Weight loss contraindication 89362005
Hyponatremia contraindication 89627008
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bleeding contraindication 131148009
Impaired renal function disorder contraindication 197663003
Mania contraindication 231494001
Hypomania contraindication 231496004
Interstitial lung disease contraindication 233703007 DOID:3082
Disease of liver contraindication 235856003 DOID:409
Hypertriglyceridemia contraindication 302870006
Serotonin syndrome contraindication 371089000
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial infarction in recovery phase contraindication 418044006
Congenital long QT syndrome contraindication 442917000
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.05 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 5.98 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.65 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 5.70 PDSP
5-hydroxytryptamine receptor 6 GPCR Ki 5.55 PDSP
Sodium-dependent dopamine transporter Transporter Ki 5.44 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 7.05 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 7.60 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 6.44 CHEMBL
Transporter Transporter Ki 6.86 CHEMBL
Transporter Transporter IC50 6.19 CHEMBL

External reference:

IDSource
4023901 VUID
N0000021906 NUI
D00821 KEGG_DRUG
99300-78-4 SECONDARY_CAS_RN
4020846 VANDF
4023901 VANDF
C0078569 UMLSCUI
CHEBI:9943 CHEBI
CHEMBL637 ChEMBL_ID
CHEMBL1201066 ChEMBL_ID
DB00285 DRUGBANK_ID
D000069470 MESH_DESCRIPTOR_UI
5656 PUBCHEM_CID
7321 IUPHAR_LIGAND_ID
6358 INN_ID
GRZ5RCB1QG UNII
151692 RXNORM
5669 MMSL
594 MMSL
87651 MMSL
d03181 MMSL
004428 NDDF
004429 NDDF
108432009 SNOMEDCT_US
108434005 SNOMEDCT_US
372490001 SNOMEDCT_US
GRZ5RCB1QG INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7384 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7385 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7386 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9147 TABLET 25 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9148 TABLET 37.50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9149 TABLET 50 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9157 TABLET 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-9163 TABLET 100 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8346 TABLET 75 mg ORAL ANDA 34 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8509 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 33 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8510 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 33 sections
venlafaxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7075 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 31 sections
venlafaxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7076 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 31 sections
venlafaxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7077 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 31 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7487 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7488 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 32 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7489 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 32 sections
VENLAFAXINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 10135-825 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL ANDA 20 sections
VENLAFAXINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 10135-826 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 20 sections
VENLAFAXINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 10135-827 CAPSULE, EXTENDED RELEASE 150 mg ORAL ANDA 20 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13811-712 TABLET, EXTENDED RELEASE 37.50 mg ORAL NDA authorized generic 28 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13811-713 TABLET, EXTENDED RELEASE 75 mg ORAL NDA authorized generic 28 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13811-714 TABLET, EXTENDED RELEASE 150 mg ORAL NDA authorized generic 28 sections
Venlafaxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13811-715 TABLET, EXTENDED RELEASE 225 mg ORAL NDA authorized generic 28 sections
EffexorXR HUMAN PRESCRIPTION DRUG LABEL 1 16590-085 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL NDA 16 sections
EffexorXR HUMAN PRESCRIPTION DRUG LABEL 1 16590-086 CAPSULE, EXTENDED RELEASE 75 mg ORAL NDA 16 sections
EffexorXR HUMAN PRESCRIPTION DRUG LABEL 1 16590-087 CAPSULE, EXTENDED RELEASE 150 mg ORAL NDA 16 sections
VENLAFAXINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-644 TABLET 37.50 mg ORAL ANDA 22 sections
EffexorXR Extended-Release HUMAN PRESCRIPTION DRUG LABEL 1 21695-045 CAPSULE, EXTENDED RELEASE 37.50 mg ORAL NDA 30 sections
EffexorXR Extended-Release HUMAN PRESCRIPTION DRUG LABEL 1 21695-046 CAPSULE, EXTENDED RELEASE 75 mg ORAL NDA 30 sections