troleandomycin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 2769 2751-09-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • troleandomycin
  • oleandomycin triacetate
  • cyclamycin
  • evramicina
  • evramycin
  • oleomycin
  • triacetyloleandomycin
A macrolide antibiotic that is similar to ERYTHROMYCIN.
  • Molecular weight: 813.98
  • Formula: C41H67NO15
  • CLOGP: 4.20
  • LIPINSKI: 2
  • HAC: 16
  • HDO: 0
  • TPSA: 184.19
  • ALOGS: -4.63
  • ROTB: 12

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 27, 1969 FDA PFIZER

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01FA08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Macrolides
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:86501 cytochrome p450 3a4 inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pneumococcal pneumonia indication 233607000
Upper Respiratory Streptococcal Infection indication
Asthma off-label use 195967001 DOID:2841

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4022401 VUID
N0000146829 NUI
D01322 KEGG_DRUG
4018507 VANDF
4022401 VANDF
C0041165 UMLSCUI
CHEBI:45735 CHEBI
TAO PDB_CHEM_ID
CHEMBL564085 ChEMBL_ID
D014217 MESH_DESCRIPTOR_UI
DB13179 DRUGBANK_ID
202225 PUBCHEM_CID
805 INN_ID
C4DZ64560D UNII
10209 IUPHAR_LIGAND_ID
10864 RXNORM
5643 MMSL
d01076 MMSL
002765 NDDF
371016002 SNOMEDCT_US
64130008 SNOMEDCT_US

Pharmaceutical products:

None