dirithromycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 925 62013-04-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dirithromycin
  • dirythromycin
  • LY-237216
  • LY 237216
  • Molecular weight: 835.09
  • Formula: C42H78N2O14
  • CLOGP: 2.74
  • LIPINSKI: 2
  • HAC: 16
  • HDO: 5
  • TPSA: 196.33
  • ALOGS: -3.56
  • ROTB: 12

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.50 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 10 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 0.23 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
June 19, 1995 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01FA13 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Macrolides
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Infection of skin AND/OR subcutaneous tissue indication 19824006
Bronchitis indication 32398004 DOID:6132
Pneumonia due to Streptococcus indication 34020007
Streptococcal tonsillitis indication 41582007
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Tonsillitis indication 90176007 DOID:10456
Acute Moraxella catarrhalis bronchitis indication 195722003
Acute bacterial bronchitis indication 233598009
Pneumonia indication 233604007 DOID:552
Streptococcus pyogenes infection indication 302809008
Pharyngitis indication 405737000 DOID:2275
Infection due to Staphylococcus aureus indication 406602003
Legionella Pneumophila Pneumonia indication
Haemophilus Influenzae Bronchitis indication
Streptococcus Pneumoniae Bronchitis indication
Bacteremia contraindication 5758002
Conduction disorder of the heart contraindication 44808001
Disease of liver contraindication 235856003 DOID:409
Pseudomembranous enterocolitis contraindication 397683000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.75 acidic
pKa2 8.65 Basic
pKa3 6.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4020907 VUID
N0000148396 NUI
D03865 KEGG_DRUG
23437 RXNORM
4020907 VANDF
C0058445 UMLSCUI
CHEBI:474014 CHEBI
DI0 PDB_CHEM_ID
CHEMBL1237072 ChEMBL_ID
CHEMBL3039471 ChEMBL_ID
DB00954 DRUGBANK_ID
C053853 MESH_SUPPLEMENTAL_RECORD_UI
5694 INN_ID
1801D76STL UNII
6473883 PUBCHEM_CID
4620 MMSL
d03844 MMSL
005044 NDDF
370764007 SNOMEDCT_US
96035007 SNOMEDCT_US

Pharmaceutical products:

None