mydecamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 1861 35457-80-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mydecamycin
  • aboren
  • Espinomycin A
  • Medecamycin A1
  • medemycin
  • Medemycin A1
  • midecamycin
  • Midecamycin A1
  • Platenomycin B1
  • rubimycin
  • turimycin
macrolide antibiotic from Streptomyces hygroscopicus JA 6599; structure
  • Molecular weight: 813.98
  • Formula: C41H67NO15
  • CLOGP: 3.27
  • LIPINSKI: 2
  • HAC: 16
  • HDO: 3
  • TPSA: 206.05
  • ALOGS: -3.94
  • ROTB: 14

Drug dosage:

DoseUnitRoute
1.20 g O
1 g P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 31.59 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.861 High 0.88
caco2-efflux Caco-2 efflux ratio (BA/AB) 10.839 High 0.88
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 13.274 10^-6 cm/s High 0.88
dh-clint Dog hepatocyte intrinsic clearance 26.122 uL/min/10^6 cells High 0.88
dppb Dog plasma protein binding (% unbound) 38.800 % High 0.88
fcs-ppb Fetal calf serum protein binding (% unbound) 37.760 % High 0.88
herg hERG pIC50 4.524 pIC50 High 0.88
hh-clint Human hepatocyte intrinsic clearance 19.815 uL/min/10^6 cells High 0.88
hlm-clint Human liver microsomal intrinsic clearance 149.968 uL/min/mg protein High 0.88
hppb Human plasma protein binding (% unbound) 38.090 % High 0.88
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK,TGFBR1 19
kinase-selectivity-class MAP2K6 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 9.772 High 0.88
mh-clint Mouse hepatocyte intrinsic clearance 56.885 High 0.88
mppb Mouse plasma protein binding (% unbound) 30 High 0.88
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 17.258 High 0.88
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 39.070 % High 0.88
rh-clint Rat hepatocyte intrinsic clearance 74.645 uL/min/10^6 cells High 0.88
rh-fuinc Rat hepatocyte fraction unbound in incubation 71.710 % High 0.88
rppb Rat plasma protein binding (% unbound) 39.950 % High 0.88
solubility-dd Solubility at pH 7.4 in DMSO 579.429 uM High 0.88

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01FA03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Macrolides
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents

Related Drugs by ATC class:

J01FA Macrolides 13 drugs
azithromycinclarithromycindirithromycinerythromycinflurithromycinjosamycinmiocamycinoleandomycinrokitamycinroxithromycinspiramycintelithromycin show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.8 acidic
pKa2 13.95 acidic
pKa3 7.88 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01339 KEGG_DRUG
C0066531 UMLSCUI
CHEMBL444963 ChEMBL_ID
CHEMBL448615 ChEMBL_ID
C026483 MESH_SUPPLEMENTAL_RECORD_UI
C011138 MESH_SUPPLEMENTAL_RECORD_UI
5282169 PUBCHEM_CID
DB13456 DRUGBANK_ID
30005 RXNORM
005381 NDDF
703378009 SNOMEDCT_US
703379001 SNOMEDCT_US
CHEBI:31845 CHEBI
13158 IUPHAR_LIGAND_ID
3461 INN_ID
N34Z0Y5UH7 UNII

Pharmaceutical products:

None