flurithromycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 1221 82664-20-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • flurithromycin
  • 8-Fluoroerythromycin A
  • 8-Fluoroerythromycin
fluorine derivative of erythromycin
  • Molecular weight: 751.93
  • Formula: C37H66FNO13
  • CLOGP: 1.42
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 5
  • TPSA: 193.91
  • ALOGS: -3.33
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.75 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.708 Moderate 0.76
caco2-efflux Caco-2 efflux ratio (BA/AB) 65.313 Moderate 0.76
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.504 10^-6 cm/s Moderate 0.76
dh-clint Dog hepatocyte intrinsic clearance 6.252 uL/min/10^6 cells Moderate 0.76
dppb Dog plasma protein binding (% unbound) 39.730 % Moderate 0.76
fcs-ppb Fetal calf serum protein binding (% unbound) 40.950 % Moderate 0.76
herg hERG pIC50 4.186 pIC50 Moderate 0.76
hh-clint Human hepatocyte intrinsic clearance 1.629 uL/min/10^6 cells Moderate 0.76
hlm-clint Human liver microsomal intrinsic clearance 15.241 uL/min/mg protein Moderate 0.76
hppb Human plasma protein binding (% unbound) 47.870 % Moderate 0.76
kinase-safety-class ACVR2B,AXL,CAMK2D,CDK5,EIF2AK3,GRK2,ITK,MAP2K6,MAP3K21,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK 16
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.968 High 0.82
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 5.495 Moderate 0.76
mh-clint Mouse hepatocyte intrinsic clearance 4.529 Moderate 0.76
mppb Mouse plasma protein binding (% unbound) 38.800 Moderate 0.76
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 6.792 Moderate 0.76
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 0.82
pppb Pig plasma protein binding (% unbound) 48.790 % Moderate 0.76
rat-kpuu-brain Rat brain Kpuu 0.015 % High 0.82
rh-clint Rat hepatocyte intrinsic clearance 3.236 uL/min/10^6 cells Moderate 0.76
rh-fuinc Rat hepatocyte fraction unbound in incubation 75.300 % Moderate 0.76
rppb Rat plasma protein binding (% unbound) 41.900 % Moderate 0.76
solubility-dd Solubility at pH 7.4 in DMSO 741.310 uM Moderate 0.76

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01FA14 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Macrolides
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:36047 antibacterial drug

Related Drugs by ATC class:

J01FA Macrolides 13 drugs
azithromycinclarithromycindirithromycinerythromycinjosamycinmiocamycinmydecamycinoleandomycinrokitamycinroxithromycinspiramycintelithromycin show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07242 KEGG_DRUG
C0060591 UMLSCUI
CHEBI:131719 CHEBI
CHEMBL2106403 ChEMBL_ID
DB13338 DRUGBANK_ID
C045925 MESH_SUPPLEMENTAL_RECORD_UI
12927 IUPHAR_LIGAND_ID
5534 INN_ID
56C9DTE69V UNII
71260 PUBCHEM_CID

Pharmaceutical products:

None