miocamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 1815 55881-07-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • miokamycin
  • acecamycin
  • midecamycin acetate
  • miocamycin
  • ponsinomycin
A macrolide antibiotic that has a wide antimicrobial spectrum and is particularly effective in respiratory and genital infections.
  • Molecular weight: 898.05
  • Formula: C45H71NO17
  • CLOGP: 5.11
  • LIPINSKI: 3
  • HAC: 18
  • HDO: 1
  • TPSA: 218.19
  • ALOGS: -4.53
  • ROTB: 18

Drug dosage:

DoseUnitRoute
1.20 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.776 Moderate 0.76
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.914 Moderate 0.76
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 31.696 10^-6 cm/s Moderate 0.76
dh-clint Dog hepatocyte intrinsic clearance 85.901 uL/min/10^6 cells Moderate 0.76
dppb Dog plasma protein binding (% unbound) 11.930 % Moderate 0.76
fcs-ppb Fetal calf serum protein binding (% unbound) 17.150 % Moderate 0.76
herg hERG pIC50 4.762 pIC50 Moderate 0.76
hh-clint Human hepatocyte intrinsic clearance 153.462 uL/min/10^6 cells Moderate 0.76
hlm-clint Human liver microsomal intrinsic clearance 263.027 uL/min/mg protein Moderate 0.76
hppb Human plasma protein binding (% unbound) 13.410 % Moderate 0.76
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PLK1,PRKDC,STK33,SYK,TEK,TGFBR1 26
kinase-selectivity-class GRK2,MAP2K6 2
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.899 Moderate 0.76
mh-clint Mouse hepatocyte intrinsic clearance 141.579 Moderate 0.76
mppb Mouse plasma protein binding (% unbound) 9.320 Moderate 0.76
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 10.839 Moderate 0.76
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 15.310 % Moderate 0.76
rh-clint Rat hepatocyte intrinsic clearance 143.880 uL/min/10^6 cells Moderate 0.76
rh-fuinc Rat hepatocyte fraction unbound in incubation 45.010 % Moderate 0.76
rppb Rat plasma protein binding (% unbound) 11.600 % Moderate 0.76
solubility-dd Solubility at pH 7.4 in DMSO 257.632 uM Moderate 0.76

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01FA11 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Macrolides
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:33282 antibacterial agent

Related Drugs by ATC class:

J01FA Macrolides 13 drugs
azithromycinclarithromycindirithromycinerythromycinflurithromycinjosamycinmydecamycinoleandomycinrokitamycinroxithromycinspiramycintelithromycin show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.8 acidic
pKa2 7.88 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000168430 NUI
D01636 KEGG_DRUG
C0026202 UMLSCUI
CHEBI:749137 CHEBI
CHEMBL1091024 ChEMBL_ID
D015644 MESH_DESCRIPTOR_UI
DB13287 DRUGBANK_ID
5282188 PUBCHEM_CID
236200 RXNORM
004200 NDDF
005382 NDDF
734560006 SNOMEDCT_US
3T48CPS7U2 UNII

Pharmaceutical products:

None