erythromycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 1048 114-07-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • erythromycin gluceptate
  • erythromycin lactobionate
  • erythromycin stearate
  • erythromycin
  • Erythromycin A
  • erythrocin
  • erythromycin phosphate
  • erythromycin thiocyanate
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
  • Molecular weight: 733.94
  • Formula: C37H67NO13
  • CLOGP: 1.63
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 5
  • TPSA: 193.91
  • ALOGS: -3.20
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O
2 g O
1 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 90.88 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 35 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.95 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.10 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.563 High 0.82
caco2-efflux Caco-2 efflux ratio (BA/AB) 68.391 High 0.82
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.467 10^-6 cm/s High 0.82
dh-clint Dog hepatocyte intrinsic clearance 5.636 uL/min/10^6 cells High 0.82
dppb Dog plasma protein binding (% unbound) 44.670 % High 0.82
fcs-ppb Fetal calf serum protein binding (% unbound) 46.440 % High 0.82
herg hERG pIC50 4.104 pIC50 High 0.82
hh-clint Human hepatocyte intrinsic clearance 1.476 uL/min/10^6 cells High 0.82
hlm-clint Human liver microsomal intrinsic clearance 14.289 uL/min/mg protein High 0.82
hppb Human plasma protein binding (% unbound) 52.470 % High 0.82
kinase-safety-class ACVR2B,AXL,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK7,NTRK2,PDK1,PDK2,PRKDC,TEK 16
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 2.018 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 4.808 High 0.82
mh-clint Mouse hepatocyte intrinsic clearance 4.529 High 0.82
mppb Mouse plasma protein binding (% unbound) 47.410 High 0.82
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 5.105 High 0.82
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 54.820 % High 0.82
rat-kpuu-brain Rat brain Kpuu 0.016 % High 1
rh-clint Rat hepatocyte intrinsic clearance 3.342 uL/min/10^6 cells High 0.82
rh-fuinc Rat hepatocyte fraction unbound in incubation 77.290 % High 0.82
rppb Rat plasma protein binding (% unbound) 46.040 % High 0.82
solubility-dd Solubility at pH 7.4 in DMSO 796.159 uM High 0.82

Approvals:

DateAgencyCompanyOrphan
June 24, 1964 FDA ARBOR PHARMS LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 3693.73 12.06 2600 48395 461009 90116443
International normalised ratio fluctuation 282.81 12.06 94 50901 2999 90574453
Bloody discharge 223.89 12.06 73 50922 2190 90575262
Grip strength 203.82 12.06 100 50895 8865 90568587
Lyme disease 171.99 12.06 71 50924 4191 90573261
Breast cancer stage III 133.75 12.06 199 50796 84248 90493204
Dislocation of vertebra 133.36 12.06 161 50834 55807 90521645
Porphyria acute 127.98 12.06 95 50900 17880 90559572
Adjustment disorder with depressed mood 115.67 12.06 151 50844 56602 90520850
Lupus vulgaris 109.60 12.06 131 50864 44928 90532524
Drug tolerance decreased 106.79 12.06 110 50885 32020 90545432
Abortion spontaneous 101.22 12.06 138 50857 53918 90523534
Foot deformity 100.86 12.06 145 50850 59506 90517946
Bone erosion 95.73 12.06 133 50862 52888 90524564
Autoimmune disorder 92.88 12.06 160 50835 76584 90500868
Retinitis 88.95 12.06 109 50886 38349 90539103
X-ray abnormal 88.15 12.06 118 50877 45306 90532146
Exostosis 88.14 12.06 128 50867 53006 90524446
Laryngitis 83.80 12.06 122 50873 50631 90526821
Death 81.56 12.06 82 50913 456469 90120983
Sleep disorder due to a general medical condition 80.43 12.06 112 50883 44626 90532826
Ear infection 78.64 12.06 141 50854 69634 90507818
Amnesia 77.99 12.06 182 50813 108323 90469129
Seronegative arthritis 76.64 12.06 71 50924 18163 90559289
Laboratory test abnormal 75.57 12.06 105 50890 41749 90535703
Colitis ulcerative 72.07 12.06 125 50870 60141 90517311
Hepatic cirrhosis 71.51 12.06 128 50867 63125 90514327
Swollen joint count 71.35 12.06 50 50945 8603 90568849
Wound infection 70.57 12.06 173 50822 106229 90471223
Maternal exposure timing unspecified 67.64 12.06 73 50922 22410 90555042
Delirium 67.43 12.06 168 50827 104191 90473261
Frequent bowel movements 66.66 12.06 117 50878 56818 90520634
Deep vein thrombosis postoperative 66.04 12.06 132 50863 70677 90506775
Pain 62.33 12.06 319 50676 996022 89581430
Grip strength decreased 61.90 12.06 151 50844 92425 90485027
Rectal haemorrhage 59.68 12.06 139 50856 82605 90494847
Walking aid user 59.55 12.06 86 50909 35420 90542032
Visual impairment 58.83 12.06 186 50809 132179 90445273
Completed suicide 57.48 12.06 7 50988 145051 90432401
Wheezing 56.94 12.06 275 50720 237805 90339647
Exposure during pregnancy 56.03 12.06 274 50721 238136 90339316
Anaemia 54.67 12.06 71 50924 352731 90224721
Road traffic accident 54.17 12.06 158 50837 107468 90469984
Bursitis 54.00 12.06 180 50815 131474 90445978
Maternal exposure during pregnancy 53.91 12.06 367 50628 359696 90217756
Drug ineffective 53.66 12.06 510 50485 1383788 89193664
Lupus-like syndrome 52.86 12.06 97 50898 48749 90528703
Fall 52.72 12.06 121 50874 481689 90095763
Anaphylactic reaction 52.49 12.06 137 50858 87387 90490065
Pancreatitis 52.22 12.06 119 50876 69707 90507745
Amniotic cavity infection 52.10 12.06 22 50973 1374 90576078
Monocytosis 52.10 12.06 20 50975 974 90576478
Necrosis ischaemic 52.08 12.06 20 50975 975 90576477
White blood cell count increased 51.86 12.06 116 50879 67125 90510327
Iron deficiency 51.57 12.06 43 50952 9569 90567883
Ulcerative keratitis 51.34 12.06 29 50966 3424 90574028
Hypotension 50.92 12.06 65 50930 325332 90252120
Toxicity to various agents 48.77 12.06 54 50941 287792 90289660
C-reactive protein abnormal 45.99 12.06 167 50828 127262 90450190
Spondylitis 44.35 12.06 47 50948 14131 90563321
Feeling hot 43.63 12.06 119 50876 77889 90499563
Pulmonary fibrosis 43.21 12.06 146 50849 107357 90470095
Anti-cyclic citrullinated peptide antibody 41.43 12.06 63 50932 27158 90550294
Rheumatic fever 41.10 12.06 183 50812 152938 90424514
Joint range of motion decreased 40.96 12.06 168 50827 135475 90441977
Neutropenia 40.55 12.06 40 50955 224864 90352588
Off label use 40.53 12.06 411 50584 1101841 89475611
Faecal volume decreased 40.32 12.06 12 50983 264 90577188
Asthma 39.34 12.06 252 50743 241908 90335544
Febrile neutropenia 39.27 12.06 20 50975 158329 90419123
Pregnancy 39.14 12.06 99 50896 61948 90515504
Swollen joint count increased 38.66 12.06 144 50851 111062 90466390
Peripheral venous disease 38.26 12.06 119 50876 83802 90493650
Pneumonia streptococcal 37.40 12.06 20 50975 2121 90575331
Injection site pain 37.36 12.06 26 50969 173673 90403779
Beta haemolytic streptococcal infection 37.03 12.06 21 50974 2498 90574954
Oedema 36.67 12.06 215 50780 200080 90377372
Intentional overdose 36.04 12.06 5 50990 93829 90483623
Malignant neoplasm progression 36.02 12.06 8 50987 106862 90470590
Red blood cell sedimentation rate increased 35.71 12.06 115 50880 82480 90494972
Rheumatoid factor positive 35.23 12.06 190 50805 171460 90405992
Weight fluctuation 34.83 12.06 49 50946 19700 90557752
Acute kidney injury 34.57 12.06 81 50914 320306 90257146
Product dose omission issue 34.56 12.06 70 50925 291617 90285835
Hypercholesterolaemia 34.53 12.06 130 50865 100762 90476690
Abdominal pain upper 33.72 12.06 310 50685 332364 90245088
Umbilical erythema 33.49 12.06 8 50987 72 90577380
Mass excision 33.06 12.06 11 50984 352 90577100
Disease progression 32.95 12.06 24 50971 156591 90420861
Platelet count increased 32.78 12.06 49 50946 20810 90556642
Infection 32.55 12.06 329 50666 361765 90215687
Exposure to SARS-CoV-2 32.21 12.06 19 50976 2433 90575019
Respiratory disorder 31.50 12.06 94 50901 64722 90512730
Memory impairment 31.25 12.06 204 50791 197040 90380412
Forced expiratory volume decreased 31.20 12.06 26 50969 5782 90571670
Hyponatraemia 28.70 12.06 20 50975 133518 90443934
Type 2 diabetes mellitus 28.51 12.06 204 50791 203040 90374412
Haemoglobin decreased 27.83 12.06 30 50965 161926 90415526
Sciatica 27.83 12.06 122 50873 101260 90476192
Purpura senile 27.40 12.06 11 50984 604 90576848
Secretion discharge 27.38 12.06 39 50956 15857 90561595
Facet joint syndrome 26.70 12.06 118 50877 98271 90479181
Urticaria 26.60 12.06 281 50714 312453 90264999
White blood cell count decreased 26.51 12.06 33 50962 167076 90410376
Stevens-Johnson syndrome 26.47 12.06 54 50941 29322 90548130
Overdose 26.24 12.06 30 50965 157679 90419773
Drug abuse 26.12 12.06 7 50988 82340 90495112
Mobility decreased 26.08 12.06 235 50760 250499 90326953
Pneumococcal infection 25.67 12.06 13 50982 1232 90576220
Vomiting 24.76 12.06 599 50396 787694 89789758
Bronchial obstruction 24.61 12.06 14 50981 1675 90575777
Tarsal tunnel syndrome 24.60 12.06 10 50985 567 90576885
Vertigo positional 24.53 12.06 18 50977 3326 90574126
Serum sickness-like reaction 24.42 12.06 10 50985 578 90576874
Lip dry 24.38 12.06 117 50878 100838 90476614
Blood cholesterol increased 24.27 12.06 200 50795 207812 90369640
Osteoporosis 24.13 12.06 113 50882 96418 90481034
Joint dislocation 23.92 12.06 67 50928 44515 90532937
Death neonatal 23.88 12.06 15 50980 2150 90575302
Prescribed overdose 23.47 12.06 113 50882 97512 90479940
Pancytopenia 23.31 12.06 20 50975 120243 90457209
SARS-CoV-2 test positive 23.27 12.06 30 50965 11098 90566354
Ototoxicity 22.65 12.06 14 50981 1950 90575502
Contusion 22.43 12.06 228 50767 250988 90326464
Muscular weakness 21.64 12.06 194 50801 206472 90370980
Atrial fibrillation 21.60 12.06 26 50969 133585 90443867
Live birth 21.56 12.06 95 50900 79012 90498440
Premature baby 21.31 12.06 45 50950 25032 90552420
Periumbilical abscess 21.15 12.06 7 50988 220 90577232
Eye inflammation 21.04 12.06 24 50971 7827 90569625
Liver disorder 20.79 12.06 128 50867 121141 90456311
Lip swelling 20.69 12.06 58 50937 38552 90538900
Catheter site abscess 20.36 12.06 7 50988 248 90577204
Lower limb fracture 20.15 12.06 98 50897 84915 90492537
Jarisch-Herxheimer reaction 20.12 12.06 8 50987 428 90577024
Urinary tract infection 20.06 12.06 96 50899 305536 90271916
Corneal neovascularisation 19.63 12.06 6 50989 145 90577307
Flushing 19.35 12.06 13 50982 88478 90488974
Obesity 19.13 12.06 113 50882 105394 90472058
Caesarean section 18.98 12.06 36 50959 18541 90558911
Blood pressure increased 18.84 12.06 53 50942 197164 90380288
Dysphoria 18.54 12.06 20 50975 6134 90571318
Benign laryngeal neoplasm 18.16 12.06 4 50991 24 90577428
Fatigue 18.11 12.06 503 50492 1153520 89423932
Cardiac failure 18.03 12.06 21 50974 109475 90467977
Duodenal ulcer perforation 17.95 12.06 197 50798 221091 90356361
Ergot poisoning 17.75 12.06 5 50990 90 90577362
Resorption bone increased 17.48 12.06 10 50985 1209 90576243
Therapeutic product effect incomplete 17.31 12.06 176 50819 193720 90383732
Respiratory failure 17.14 12.06 25 50970 118393 90459059
Staphylococcal infection 17.05 12.06 63 50932 48376 90529076
Platelet count decreased 16.96 12.06 32 50963 136937 90440515
Spinal fusion surgery 16.71 12.06 27 50968 12256 90565196
Suicide attempt 16.59 12.06 11 50984 75388 90502064
Blister 16.31 12.06 217 50778 254781 90322671
Cardiac failure congestive 16.17 12.06 19 50976 98675 90478777
Cerebrovascular accident 16.07 12.06 28 50967 123505 90453947
Eye pain 16.02 12.06 58 50937 44110 90533342
Arthritis 15.97 12.06 154 50841 167161 90410291
Dehydration 15.93 12.06 56 50939 194391 90383061
Diplegia 15.72 12.06 10 50985 1465 90575987
Injection site swelling 15.68 12.06 7 50988 59832 90517620
Neoplasm progression 15.67 12.06 3 50992 44483 90532969
Symblepharon 15.35 12.06 6 50989 307 90577145
Pancreatic pseudocyst 15.33 12.06 8 50987 807 90576645
Vestibular disorder 15.27 12.06 10 50985 1539 90575913
Sepsis 15.27 12.06 51 50944 179763 90397689
Constipation 15.13 12.06 94 50901 280301 90297151
Pharyngeal swelling 15.11 12.06 23 50972 9921 90567531
Blood creatinine increased 15.07 12.06 21 50974 101365 90476087
Joint stiffness 15.07 12.06 85 50910 77957 90499495
Haemorrhagic diathesis 15.00 12.06 17 50978 5507 90571945
Neutrophil count decreased 14.99 12.06 11 50984 71521 90505931
Premature rupture of membranes 14.91 12.06 17 50978 5541 90571911
Pancreatic mass 14.91 12.06 9 50986 1202 90576250
Blood glucose increased 14.90 12.06 19 50976 95227 90482225
Injury 14.78 12.06 173 50822 197176 90380276
Mucosal inflammation 14.70 12.06 7 50988 57618 90519834
Sleep disorder due to general medical condition, insomnia type 14.60 12.06 123 50872 128571 90448881
Corneal perforation 14.42 12.06 7 50988 606 90576846
Coma 14.17 12.06 12 50983 72620 90504832
Hypoaesthesia 14.17 12.06 252 50743 313958 90263494
Gastrointestinal haemorrhage 14.12 12.06 18 50977 90230 90487222
Injection site erythema 14.06 12.06 21 50974 98481 90478971
Night sweats 14.05 12.06 122 50873 128644 90448808
Hot flush 14.03 12.06 8 50987 59480 90517972
Gastrointestinal disorder 13.84 12.06 212 50783 256475 90320977
Anxiety 13.81 12.06 248 50747 309524 90267928
Chest pain 13.58 12.06 254 50741 319391 90258061
Somnolence 13.52 12.06 66 50929 209018 90368434
Photophobia 13.47 12.06 34 50961 21235 90556217
Urticarial vasculitis 13.47 12.06 8 50987 1037 90576415
Liver injury 13.44 12.06 151 50844 170416 90407036
Drug interaction 13.28 12.06 224 50771 276229 90301223
Anal candidiasis 13.22 12.06 3 50992 21 90577431
Cystitis 13.05 12.06 11 50984 66707 90510745
Injection site pruritus 13.04 12.06 7 50988 53827 90523625
Vaginal lesion 12.90 12.06 6 50989 472 90576980
Oligohydramnios 12.90 12.06 18 50977 7183 90570269
Lung disorder 12.87 12.06 135 50860 149748 90427704
Cardio-respiratory arrest 12.86 12.06 10 50985 63130 90514322
Sleep disorder 12.85 12.06 169 50826 197861 90379591
Infantile haemangioma 12.81 12.06 4 50991 104 90577348
Hip arthroplasty 12.78 12.06 80 50915 76128 90501324
Oral pain 12.78 12.06 44 50951 32639 90544813
Abdominal pain 12.76 12.06 302 50693 395419 90182033
Hypocalcaemia 12.70 12.06 4 50991 42364 90535088
Hypokalaemia 12.69 12.06 35 50960 131081 90446371
Maternal drugs affecting foetus 12.55 12.06 15 50980 5140 90572312
Gait disturbance 12.49 12.06 211 50784 260285 90317167
Seizure 12.47 12.06 44 50951 152585 90424867
Cardiac arrest neonatal 12.46 12.06 4 50991 114 90577338
Dry mouth 12.33 12.06 158 50837 183901 90393551
Appetite disorder 12.32 12.06 20 50975 9113 90568339
Thinking abnormal 12.31 12.06 23 50972 11709 90565743
Economic problem 12.31 12.06 12 50983 3269 90574183
Transaminases increased 12.10 12.06 3 50992 37189 90540263

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 466.25 14.10 306 11315 99083 42510631
Toxic epidermal necrolysis 73.85 14.10 60 11561 26690 42583024
Hyphaema 72.69 14.10 20 11601 700 42609014
Rhabdomyolysis 71.70 14.10 97 11524 77922 42531792
Drug interaction 64.70 14.10 189 11432 266810 42342904
Product packaging issue 57.90 14.10 17 11604 754 42608960
Anti factor V antibody 52.35 14.10 13 11608 302 42609412
Premature baby 49.76 14.10 45 11576 23108 42586606
Porphyria acute 48.76 14.10 13 11608 403 42609311
Eye pain 46.57 14.10 38 11583 16992 42592722
Dystonia 38.08 14.10 30 11591 12760 42596954
Injection site extravasation 37.79 14.10 18 11603 3104 42606610
Stupor 37.62 14.10 18 11603 3135 42606579
Hyperoxaluria 33.26 14.10 8 11613 162 42609552
Low birth weight baby 33.24 14.10 25 11596 9930 42599784
Obstruction gastric 32.92 14.10 12 11609 1056 42608658
Intraocular pressure increased 32.91 14.10 21 11600 6412 42603302
Mixed liver injury 31.68 14.10 18 11603 4456 42605258
Pyloric stenosis 30.75 14.10 11 11610 917 42608797
Foetal death 29.97 14.10 8 11613 249 42609465
Coagulation time prolonged 29.50 14.10 12 11609 1420 42608294
Measles 28.26 14.10 8 11613 311 42609403
Ischaemic hepatitis 27.73 14.10 13 11608 2164 42607550
Acute generalised exanthematous pustulosis 27.41 14.10 21 11600 8574 42601140
Hepatic failure 27.11 14.10 42 11579 38058 42571656
Crystal nephropathy 26.54 14.10 9 11612 640 42609074
Deafness bilateral 26.38 14.10 11 11610 1386 42608328
Cellulitis enterococcal 25.66 14.10 6 11615 107 42609607
Torsade de pointes 25.24 14.10 20 11601 8574 42601140
Skin wrinkling 25.00 14.10 8 11613 474 42609240
Foetal arrhythmia 24.43 14.10 6 11615 133 42609581
Brain oedema 24.36 14.10 26 11595 16301 42593413
Swelling face 23.38 14.10 33 11588 27521 42582193
Product dispensing error 22.91 14.10 18 11603 7621 42602093
Onychophagia 22.79 14.10 5 11616 66 42609648
Clonal haematopoiesis 22.29 14.10 6 11615 193 42609521
Pathogen resistance 22.16 14.10 21 11600 11429 42598285
Oligohydramnios 22.16 14.10 7 11614 398 42609316
Caesarean section 22.06 14.10 11 11610 2095 42607619
Learning disorder 21.81 14.10 9 11612 1104 42608610
Skin necrosis 21.40 14.10 16 11605 6298 42603416
Hypercapnia 21.40 14.10 15 11606 5346 42604368
Tricuspid valve disease 21.28 14.10 6 11615 230 42609484
Myoglobinuria 21.01 14.10 8 11613 795 42608919
Oculogyric crisis 20.83 14.10 10 11611 1755 42607959
Myasthenia gravis crisis 20.60 14.10 8 11613 838 42608876
Hepatic necrosis 20.58 14.10 13 11608 3900 42605814
Sepsis neonatal 19.98 14.10 6 11615 288 42609426
Respiratory acidosis 19.17 14.10 15 11606 6316 42603398
Vasculitic rash 19.11 14.10 8 11613 1018 42608696
Respiratory disorder 18.07 14.10 26 11595 22059 42587655
Visual acuity reduced 17.91 14.10 23 11598 17527 42592187
Eye swelling 17.81 14.10 19 11602 11901 42597813
SAPHO syndrome 17.74 14.10 6 11615 423 42609291
Blood creatine phosphokinase increased 17.62 14.10 40 11581 48298 42561416
Malignant neoplasm progression 17.58 14.10 4 11617 108396 42501318
Cardio-respiratory arrest neonatal 17.47 14.10 3 11618 9 42609705
Neonatal disorder 17.44 14.10 7 11614 800 42608914
Erysipelas 17.11 14.10 14 11607 6282 42603432
Skin exfoliation 16.98 14.10 36 11585 41517 42568197
Potentiating drug interaction 16.77 14.10 14 11607 6454 42603260
Sensitivity to weather change 16.60 14.10 9 11612 2034 42607680
Dermatitis contact 16.59 14.10 12 11609 4491 42605223
Stevens-Johnson syndrome 16.55 14.10 25 11596 22153 42587561
Ocular hyperaemia 16.41 14.10 21 11600 15942 42593772
Cerebral haematoma 16.35 14.10 13 11608 5597 42604117
Maternal drugs affecting foetus 15.93 14.10 11 11610 3828 42605886
Ototoxicity 15.51 14.10 9 11612 2316 42607398
Pigmentation disorder 15.42 14.10 10 11611 3138 42606576
Hypertension neonatal 15.39 14.10 4 11617 112 42609602
Exposure during pregnancy 15.27 14.10 15 11606 8533 42601181
Rash pustular 15.19 14.10 13 11608 6202 42603512
Febrile neutropenia 15.13 14.10 17 11604 185686 42424028
Foetal exposure during pregnancy 14.91 14.10 37 11584 47274 42562440
Bronchoalveolar lavage abnormal 14.85 14.10 4 11617 129 42609585
Pupillary disorder 14.75 14.10 5 11616 355 42609359
Pneumonia mycoplasmal 14.25 14.10 6 11615 774 42608940
Prescription drug used without a prescription 14.18 14.10 9 11612 2721 42606993

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 2581.43 12.23 2005 54431 452085 110080778
International normalised ratio fluctuation 273.93 12.23 96 56340 3984 110528879
Bloody discharge 229.30 12.23 76 56360 2657 110530206
Grip strength 217.41 12.23 102 56334 9039 110523824
Lyme disease 184.81 12.23 73 56363 4243 110528620
Dislocation of vertebra 183.64 12.23 163 56273 43558 110489305
Porphyria acute 168.12 12.23 110 56326 18670 110514193
Adjustment disorder with depressed mood 163.56 12.23 153 56283 43730 110489133
Breast cancer stage III 162.23 12.23 201 56235 78916 110453947
Lupus vulgaris 157.80 12.23 134 56302 33749 110499114
Foot deformity 134.51 12.23 144 56292 48336 110484527
Drug tolerance decreased 130.47 12.23 110 56326 27430 110505433
Autoimmune disorder 130.46 12.23 164 56272 65319 110467544
Maternal exposure during pregnancy 126.95 12.23 350 56086 254533 110278330
Bone erosion 123.85 12.23 135 56301 46236 110486627
X-ray abnormal 117.89 12.23 120 56316 37997 110494866
Retinitis 117.18 12.23 111 56325 32216 110500647
Exostosis 112.77 12.23 128 56308 45828 110487035
Laryngitis 110.71 12.23 122 56314 42289 110490574
Amnesia 102.46 12.23 189 56247 105219 110427644
Abortion spontaneous 100.73 12.23 105 56331 34177 110498686
Ear infection 100.17 12.23 141 56295 62591 110470272
Death 96.92 12.23 129 56307 698740 109834123
Wound infection 96.33 12.23 175 56261 96290 110436573
Seronegative arthritis 96.09 12.23 68 56368 13109 110519754
Walking aid user 94.53 12.23 88 56348 24987 110507876
Deep vein thrombosis postoperative 94.27 12.23 133 56303 59158 110473705
Grip strength decreased 89.83 12.23 153 56283 80021 110452842
Anaemia 86.49 12.23 91 56345 546995 109985868
Sleep disorder due to a general medical condition 84.49 12.23 118 56318 51994 110480869
Laboratory test abnormal 80.87 12.23 106 56330 43973 110488890
Maternal exposure timing unspecified 79.70 12.23 74 56362 20939 110511924
Hepatic cirrhosis 79.68 12.23 132 56304 67494 110465369
Rheumatic fever 77.20 12.23 184 56252 122395 110410468
Rheumatoid factor positive 75.89 12.23 191 56245 131449 110401414
Swollen joint count 75.67 12.23 50 56386 8624 110524239
Swollen joint count increased 75.08 12.23 145 56291 83516 110449347
Hypotension 74.31 12.23 95 56341 523754 110009109
Febrile neutropenia 71.72 12.23 36 56400 316731 110216132
Lupus-like syndrome 71.61 12.23 96 56340 40696 110492167
Drug abuse 68.32 12.23 6 56430 177405 110355458
Exposure during pregnancy 68.07 12.23 214 56222 167210 110365653
Wheezing 67.06 12.23 283 56153 254947 110277916
Colitis ulcerative 65.68 12.23 131 56305 77232 110455631
Joint range of motion decreased 65.30 12.23 172 56264 121660 110411203
Delirium 64.77 12.23 183 56253 134842 110398021
Visual impairment 64.29 12.23 182 56254 134246 110398617
Bursitis 64.20 12.23 178 56258 129740 110403123
Completed suicide 63.80 12.23 22 56414 242359 110290504
Anti-cyclic citrullinated peptide antibody 61.99 12.23 63 56373 19901 110512962
Toxicity to various agents 61.30 12.23 94 56342 480461 110052402
Road traffic accident 61.03 12.23 155 56281 107243 110425620
Ulcerative keratitis 60.77 12.23 35 56401 4731 110528132
Neutropenia 60.65 12.23 61 56375 374559 110158304
Pulmonary fibrosis 59.80 12.23 149 56287 101893 110430970
Frequent bowel movements 58.35 12.23 119 56317 71271 110461592
Type 2 diabetes mellitus 57.47 12.23 210 56226 177022 110355841
Malignant neoplasm progression 57.27 12.23 10 56426 174557 110358306
Product packaging issue 56.95 12.23 24 56412 1647 110531216
Red blood cell sedimentation rate increased 56.44 12.23 124 56312 78178 110454685
Pancreatitis 56.31 12.23 138 56298 93395 110439468
C-reactive protein abnormal 54.77 12.23 168 56268 129527 110403336
Fall 54.74 12.23 144 56292 603338 109929525
Hypercholesterolaemia 54.66 12.23 134 56302 90703 110442160
Infection 54.12 12.23 343 56093 361857 110171006
Pregnancy 53.98 12.23 95 56341 50972 110481891
Asthma 51.97 12.23 259 56177 250032 110282831
Hyphaema 51.90 12.23 20 56416 1087 110531776
Feeling hot 51.26 12.23 131 56305 90975 110441888
Spondylitis 51.06 12.23 44 56392 11294 110521569
Duodenal ulcer perforation 50.57 12.23 202 56234 177498 110355365
Blood cholesterol increased 49.38 12.23 206 56230 184579 110348284
Toxic epidermal necrolysis 48.08 12.23 96 56340 56631 110476232
Necrosis ischaemic 47.93 12.23 20 56416 1339 110531524
Disease progression 46.47 12.23 34 56402 244000 110288863
Respiratory disorder 45.85 12.23 108 56328 71274 110461589
Acute kidney injury 45.35 12.23 169 56267 635261 109897602
Hyponatraemia 44.55 12.23 28 56408 217625 110315238
Peripheral venous disease 44.30 12.23 118 56318 83999 110448864
Anti factor V antibody 43.99 12.23 13 56423 309 110532554
Oedema 43.38 12.23 217 56219 209759 110323104
Joint dislocation 43.34 12.23 69 56367 34121 110498742
Mobility decreased 43.29 12.23 237 56199 237185 110295678
White blood cell count increased 43.29 12.23 128 56308 96714 110436149
Monocytosis 43.18 12.23 20 56416 1720 110531143
Memory impairment 43.17 12.23 207 56229 196737 110336126
Sciatica 43.10 12.23 124 56312 92275 110440588
Blister 42.83 12.23 229 56207 227147 110305716
Haemoglobin decreased 41.98 12.23 39 56397 248688 110284175
Prescribed overdose 41.30 12.23 118 56318 87463 110445400
Liver injury 41.21 12.23 169 56267 150244 110382619
Osteoporosis 40.69 12.23 117 56319 87035 110445828
Injection site pain 39.09 12.23 21 56415 177901 110354962
Contusion 38.63 12.23 227 56209 233134 110299729
Platelet count increased 37.38 12.23 56 56380 26278 110506585
Weight fluctuation 37.17 12.23 51 56385 22094 110510769
Discomfort 36.93 12.23 211 56225 214496 110318367
Abdominal pain upper 36.21 12.23 303 56133 348808 110184055
Off label use 36.14 12.23 544 55892 1499641 109033222
Lower limb fracture 36.00 12.23 102 56334 75246 110457617
Facet joint syndrome 35.93 12.23 120 56316 96708 110436155
Anaphylactic reaction 35.83 12.23 134 56302 114166 110418697
Stevens-Johnson syndrome 35.77 12.23 76 56360 46825 110486038
Beta haemolytic streptococcal infection 35.72 12.23 21 56415 2950 110529913
Pneumonia streptococcal 35.10 12.23 22 56414 3467 110529396
Urticaria 34.82 12.23 280 56156 318577 110214286
Anti-cyclic citrullinated peptide antibody positive 34.75 12.23 184 56252 181800 110351063
Platelet count decreased 34.52 12.23 40 56396 230403 110302460
Myelosuppression 34.21 12.23 4 56432 94336 110438527
Live birth 34.11 12.23 95 56341 69389 110463474
Sleep disorder due to general medical condition, insomnia type 34.08 12.23 125 56311 105518 110427345
Iron deficiency 33.22 12.23 44 56392 18432 110514431
Helicobacter infection 32.77 12.23 181 56255 181696 110351167
Injury 32.33 12.23 177 56259 177088 110355775
Lip dry 31.93 12.23 118 56318 99965 110432898
Folliculitis 31.66 12.23 169 56267 167484 110365379
Drug ineffective 31.14 12.23 568 55868 1519972 109012891
Hip arthroplasty 31.13 12.23 80 56356 55733 110477130
Exposure to SARS-CoV-2 30.87 12.23 19 56417 2900 110529963
Drug interaction 30.73 12.23 390 56046 499793 110033070
Overdose 30.48 12.23 45 56391 233749 110299114
Intentional overdose 30.06 12.23 15 56421 132486 110400377
Rectal haemorrhage 29.99 12.23 131 56305 119702 110413161
Suicide attempt 29.69 12.23 8 56428 103386 110429477
Mass excision 29.57 12.23 10 56426 372 110532491
Ototoxicity 29.38 12.23 21 56415 4110 110528753
Constipation 29.00 12.23 90 56346 357696 110175167
Secretion discharge 28.66 12.23 43 56393 20201 110512662
Somnolence 28.45 12.23 69 56367 297380 110235483
Joint stiffness 28.28 12.23 87 56349 67156 110465707
Pain 27.74 12.23 333 56103 954622 109578241
Eye pain 27.10 12.23 71 56365 50028 110482835
Arthritis 27.06 12.23 162 56274 167424 110365439
Neutrophil count decreased 26.97 12.23 14 56422 120927 110411936
Hypoaesthesia 26.59 12.23 261 56175 313962 110218901
Rheumatoid arthritis 26.40 12.23 251 56185 299362 110233501
White blood cell count decreased 26.31 12.23 48 56388 229342 110303521
Ill-defined disorder 26.21 12.23 153 56283 156700 110376163
Fibromyalgia 26.20 12.23 163 56273 170746 110362117
Tarsal tunnel syndrome 26.03 12.23 10 56426 539 110532324
Coma 25.76 12.23 14 56422 117855 110415008
Pancytopenia 25.74 12.23 42 56394 209571 110323292
Spinal fusion surgery 25.04 12.23 27 56409 9129 110523734
Purpura senile 24.93 12.23 10 56426 605 110532258
Pneumococcal infection 24.92 12.23 14 56422 1805 110531058
Obesity 24.72 12.23 119 56317 113232 110419631
Product dose omission issue 23.96 12.23 84 56352 321698 110211165
Atrial fibrillation 23.80 12.23 51 56385 229591 110303272
Vertigo positional 23.44 12.23 18 56418 3930 110528933
Muscle injury 23.30 12.23 137 56299 140670 110392193
Eye inflammation 23.27 12.23 26 56410 9145 110523718
Systemic lupus erythematosus 22.86 12.23 214 56222 254124 110278739
Dehydration 22.86 12.23 70 56366 279441 110253422
Knee arthroplasty 22.78 12.23 79 56357 64869 110467994
Pulmonary embolism 22.76 12.23 47 56389 214427 110318436
Syncope 22.68 12.23 43 56393 202493 110330370
Night sweats 22.59 12.23 131 56305 133852 110399011
Torsade de pointes 22.54 12.23 41 56395 22559 110510304
Serum sickness-like reaction 22.54 12.23 10 56426 778 110532085
Abdominal discomfort 22.46 12.23 303 56133 393555 110139308
Corneal neovascularisation 22.20 12.23 7 56429 208 110532655
Blood creatinine increased 22.13 12.23 37 56399 182852 110350011
Hyperoxaluria 22.10 12.23 8 56428 365 110532498
Mucosal inflammation 21.63 12.23 11 56425 96130 110436733
Gastrointestinal disorder 20.96 12.23 202 56234 241750 110291113
Deafness permanent 20.94 12.23 10 56426 921 110531942
Cardio-respiratory arrest 20.94 12.23 17 56419 115819 110417044
Cardiac failure 20.86 12.23 40 56396 187586 110345277
Disability 20.80 12.23 47 56389 30176 110502687
Ergot poisoning 20.78 12.23 6 56430 131 110532732
Mixed liver injury 20.55 12.23 28 56408 12051 110520812
Neoplasm progression 20.54 12.23 4 56432 64591 110468272
Caesarean section 20.50 12.23 30 56406 13787 110519076
Catheter site abscess 20.43 12.23 7 56429 271 110532592
Muscular weakness 20.34 12.23 205 56231 248263 110284600
Stupor 20.23 12.23 23 56413 8242 110524621
Bradycardia 20.20 12.23 30 56406 155487 110377376
Impaired healing 19.98 12.23 170 56266 196547 110336316
Blood glucose increased 19.83 12.23 23 56413 132473 110400390
Deafness bilateral 19.82 12.23 14 56422 2690 110530173
Learning disorder 19.78 12.23 9 56427 743 110532120
Cardiac failure congestive 19.74 12.23 29 56407 150971 110381892
Intraocular pressure increased 19.71 12.23 26 56410 10850 110522013
Periumbilical abscess 19.51 12.23 7 56429 311 110532552
Wound 19.46 12.23 194 56242 234243 110298620
Flushing 19.40 12.23 15 56421 104721 110428142
Gait disturbance 19.27 12.23 222 56214 277986 110254877
Orthostatic hypotension 19.26 12.23 5 56431 66244 110466619
Liver disorder 18.96 12.23 131 56305 142112 110390751
Intentional product misuse 18.91 12.23 24 56412 132880 110399983
Osteoarthritis 18.64 12.23 158 56278 182465 110350398
Glossodynia 18.57 12.23 184 56252 221820 110311043
Benign laryngeal neoplasm 18.55 12.23 4 56432 24 110532839
Pemphigus 18.52 12.23 179 56257 214391 110318472
Myoglobinuria 18.33 12.23 10 56426 1218 110531645
Sleep disorder 18.28 12.23 168 56268 198476 110334387
COVID-19 18.22 12.23 64 56372 244996 110287867
Bronchial obstruction 18.19 12.23 14 56422 3065 110529798
Hand deformity 17.74 12.23 180 56256 218326 110314537
Acute generalised exanthematous pustulosis 17.56 12.23 36 56400 21628 110511235
Measles 17.55 12.23 8 56428 663 110532200
Injection site reaction 17.48 12.23 12 56424 89058 110443805
Cerebrovascular accident 17.37 12.23 42 56394 181242 110351621
Dyspepsia 17.32 12.23 161 56275 190804 110342059
Dysgeusia 17.32 12.23 7 56429 69978 110462885
Lip swelling 17.23 12.23 61 56375 50606 110482257
Coagulation time prolonged 16.66 12.23 13 56423 2904 110529959
Heart rate decreased 16.44 12.23 11 56425 82745 110450118
Depressed level of consciousness 16.26 12.23 20 56416 112258 110420605
Resorption bone increased 16.26 12.23 10 56426 1524 110531339
Transaminases increased 16.25 12.23 6 56430 63384 110469479
Irritable bowel syndrome 16.19 12.23 141 56295 164074 110368789
Pericarditis 16.15 12.23 177 56259 218937 110313926
SARS-CoV-2 test positive 15.98 12.23 30 56406 16905 110515958
Dysphoria 15.93 12.23 18 56418 6410 110526453
Forced expiratory volume decreased 15.89 12.23 26 56410 13150 110519713
Urinary tract infection 15.56 12.23 100 56336 326182 110206681
Hypokalaemia 15.41 12.23 45 56391 182403 110350460
Amniotic cavity infection 15.26 12.23 8 56428 899 110531964
Vomiting 15.20 12.23 588 55848 910087 109622776
Anxiety 15.19 12.23 254 56182 344824 110188039
Premature rupture of membranes 15.07 12.23 15 56421 4622 110528241
Oligohydramnios 15.02 12.23 14 56422 3980 110528883
Hypomagnesaemia 15.00 12.23 6 56430 60364 110472499
Vaginal lesion 14.97 12.23 6 56430 362 110532501
Corneal perforation 14.87 12.23 8 56428 948 110531915
Urticarial vasculitis 14.63 12.23 8 56428 978 110531885
Cytokine release syndrome 14.44 12.23 9 56427 70297 110462566
Myocardial infarction 14.39 12.23 50 56386 192033 110340830
Rhabdomyolysis 14.38 12.23 108 56328 120293 110412570
Sedation 14.20 12.23 9 56427 69674 110463189
Injection site swelling 14.00 12.23 7 56429 61783 110471080
Prescribed underdose 13.90 12.23 68 56368 65106 110467757
Sepsis 13.80 12.23 104 56332 327242 110205621
Cerebral haemorrhage 13.79 12.23 8 56428 64960 110467903
Respiratory acidosis 13.69 12.23 25 56411 13801 110519062
Oculogyric crisis 13.58 12.23 13 56423 3819 110529044
Arthropathy 13.53 12.23 214 56222 287308 110245555
Therapeutic product effect incomplete 13.50 12.23 174 56262 223631 110309232
Blood pressure increased 13.46 12.23 77 56359 258296 110274567
Tricuspid valve disease 13.46 12.23 6 56430 472 110532391
Symblepharon 13.29 12.23 6 56430 486 110532377
Ischaemic hepatitis 13.23 12.23 14 56422 4634 110528229
Neuropathy peripheral 13.20 12.23 47 56389 179230 110353633
Gastrointestinal haemorrhage 13.14 12.23 42 56394 165476 110367387
Pancreatic pseudocyst 13.13 12.23 9 56427 1649 110531214
Jarisch-Herxheimer reaction 13.07 12.23 8 56428 1209 110531654
Anal candidiasis 13.06 12.23 3 56433 25 110532838
Pharyngeal oedema 12.97 12.23 27 56409 16401 110516462
Ascites 12.95 12.23 17 56419 92791 110440072
Cardiac arrest neonatal 12.95 12.23 3 56433 26 110532837
Economic problem 12.76 12.23 13 56423 4118 110528745
Dry mouth 12.72 12.23 157 56279 199791 110333072
Hypocalcaemia 12.57 12.23 9 56427 65357 110467506
Haematochezia 12.52 12.23 25 56411 115499 110417364
Hyperglycaemia 12.49 12.23 15 56421 85075 110447788
Myasthenia gravis crisis 12.40 12.23 9 56427 1805 110531058
Cardiogenic shock 12.25 12.23 7 56429 57331 110475532

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D10AF02 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Antiinfectives for treatment of acne
ATC D10AF52 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Antiinfectives for treatment of acne
ATC J01FA01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
Macrolides
ATC S01AA17 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
FDA CS M0028311 Macrolides
FDA PE N0000009982 Decreased Sebaceous Gland Activity
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors
FDA EPC N0000175877 Macrolide
FDA EPC N0000175935 Macrolide Antimicrobial
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:76969 bacterial metabolite
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

D10AF Antiinfectives for treatment of acne 6 drugs
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J01FA Macrolides 13 drugs
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S01AA Antibiotics 27 drugs
amikacinampicillinazidamfenicolazithromycinbacitracinbenzylpenicillincefmenoximecefuroximechloramphenicolchlortetracyclinedibekacindihydrostreptomycin show all 27 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute otitis media indication 3110003
Listeriosis indication 4241002 DOID:11573
Gonorrhea indication 15628003 DOID:7551
Haemophilus Influenzae Acute Otitis Media indication 19021002
Infection of skin AND/OR subcutaneous tissue indication 19824006
Acute gonococcal cervicitis indication 20943002 DOID:10615
Pertussis indication 27836007
Acute gonococcal urethritis indication 29864006
Neonatal conjunctivitis indication 34298002 DOID:9699
Gonorrhea of rectum indication 42746002
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Bacterial pneumonia indication 53084003 DOID:874
Acute gonococcal endometritis indication 65295003 DOID:7527
Acute bacterial sinusitis indication 75498004
Syphilis indication 76272004
Pneumococcal pharyngitis indication 76651006
Nongonococcal urethritis indication 84619001
Acne vulgaris indication 88616000
Urethritis due to Chlamydia trachomatis indication 179101003
Chlamydial conjunctivitis indication 231861005 DOID:13800
Pneumococcal pneumonia indication 233607000
Chlamydial pneumonia indication 233609002
Neonatal pneumonia indication 233619008
Erythrasma indication 238418005 DOID:4131
Streptococcus pyogenes infection indication 302809008
Infective otitis media indication 312218008
Diphtheria indication 397428000
Infection due to Staphylococcus aureus indication 406602003
Recurrent Persistent Urethritis indication
Preoperative Bowel Preparation indication
Superficial Ocular Infection indication
Prevention of Bacterial Endocarditis indication
Chlamydia Cervicitis indication
Rectal Chlamydia Trachomatis Infection indication
Prevention of Neonatal Ophthalmia indication
Pneumococcal Acute Otitis Media indication
Legionnaires' Disease indication
Rheumatic Fever Prevention indication
Trachoma off-label use 2576002 DOID:11265
Inhalational anthrax off-label use 11389007
Actinomycotic infection off-label use 11817007 DOID:8478
Enteric campylobacteriosis off-label use 18081009
Lyme disease off-label use 23502006 DOID:11729
Granuloma inguinale off-label use 28867007 DOID:9113
Sinusitis off-label use 36971009
Erysipelas off-label use 44653001 DOID:11330
Blepharoconjunctivitis off-label use 68659002 DOID:2456
Cutaneous anthrax off-label use 84980006 DOID:7426
Ecthyma off-label use 85791004
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Bacterial conjunctivitis off-label use 128350005 DOID:9700
Bacterial infection of skin off-label use 128936008
Lymphogranuloma venereum off-label use 186946009 DOID:13819
Gastroesophageal reflux disease off-label use 235595009 DOID:8534
Gastroparesis off-label use 235675006
Chancroid off-label use 266143009 DOID:13778
Meibomianitis off-label use 309779001
Infective blepharitis off-label use 312219000
Bacterial keratitis off-label use 314557000
Erysipeloid off-label use 400105005
Anthrax off-label use 409498004 DOID:7427
Relapsing fever off-label use 420079008 DOID:13034
Gastroscopy Adjunct off-label use
Listeria Monocytogenes Septicemia off-label use
Ureaplasma Pneumonia off-label use
Torsades de pointes contraindication 31722008
Third trimester pregnancy contraindication 41587001
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Cholestatic hepatitis contraindication 95556007
Anemia due to enzyme deficiency contraindication 111577008
Prolonged QT interval contraindication 111975006
Hearing disorder contraindication 128540005
Liver function tests abnormal contraindication 166603001
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Disease of liver contraindication 235856003 DOID:409
Pseudomembranous enterocolitis contraindication 397683000
Erythroderma contraindication 399992009
Porphyria contraindication 418470004
Congenital long QT syndrome contraindication 442917000
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Bacterial pneumonia Indication
Cats Upper respiratory infections Indication
Cats Secondary infections associated with panleukopenia Indication
Cats Bacterial wound infections caused by Staphylococcus species Indication
Cats Bacterial wound infections caused by Streptococcus species Indication
Cattle Bovine respiratory disease (BRD) associated with Pasturella multiocida Indication
Cattle Mastitis caused by Staphylococcus aureus Indication
Cattle Mastitis caused by Streptococcus dysgalactiae Indication
Cattle Mastitis caused by Streptococcus dysgalactiae Indication
Cattle Mastitis caused by Streptococcus uberis Indication
Chickens Prevention and reduction of lesions and in lowering severity of chronic respiratory disease Indication
Chickens Prevention of infectious coryza Indication
Chickens Prevention of chronic respiratory disease during periods of stress Indication
Chickens Chronic respiratory disease caused by Mycoplasma gallisepticum Indication
Chickens Infectious coryza caused by Hemophilus gallinarum Indication
Dogs Bacterial pneumonia Indication
Dogs upper respiratory infections Indication
Dogs Endometritis and metritis Indication
Dogs Bacterial wound infections caused by Staphylococcus species Indication
Dogs Bacterial wound infections caused by Streptococcus species Indication
Dogs Bacterial wound infections caused by Corynebacterium species Indication
Turkeys Chronic respiratory disease during periods of stress Indication
Turkeys Prevention and reduction of lesions and in lowering severity of chronic respiratory disease Indication
Turkeys Control of blue comb (nonspecific infectious enteritis) Indication

🐶 Veterinary products

ProductApplicantIngredients
Gallimycin-100P Bimeda Animal Health Limited 1
Erythro - 100, 200, Gallimycin-100 Bimeda Animal Health Limited 1
Gallimycin PFC Bimeda Animal Health Limited 1
Erythro-36 Dry, Gallimycin-36 Dry Bimeda Animal Health Limited 1
Gallimycin-36 Sterile Bimeda Animal Health Limited 1
Erythromast 36 Zoetis Inc. 1
Erythro-100 Injection Bimeda Animal Health Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 7.41 CHEMBL
Aldehyde oxidase Enzyme IC50 4.82 WOMBAT-PK
Bile salt export pump Transporter IC50 5.39 CHEMBL
Motilin receptor GPCR Ki 4.43 CHEMBL
Cytochrome P450 1B1 Enzyme IC50 4.40 CHEMBL

External reference:

IDSource
4017594 VUID
N0000145975 NUI
D00140 KEGG_DRUG
23067-13-2 SECONDARY_CAS_RN
3847-29-8 SECONDARY_CAS_RN
643-22-1 SECONDARY_CAS_RN
4017591 VANDF
4017594 VANDF
4017595 VANDF
4017596 VANDF
C0014806 UMLSCUI
CHEBI:42355 CHEBI
ERY PDB_CHEM_ID
CHEMBL532 ChEMBL_ID
CHEMBL3545060 ChEMBL_ID
CHEMBL1200506 ChEMBL_ID
CHEMBL1200510 ChEMBL_ID
D004917 MESH_DESCRIPTOR_UI
DB00199 DRUGBANK_ID
C010948 MESH_SUPPLEMENTAL_RECORD_UI
C011462 MESH_SUPPLEMENTAL_RECORD_UI
1456 IUPHAR_LIGAND_ID
39 INN_ID
63937KV33D UNII
12560 PUBCHEM_CID
24346 RXNORM
33316 MMSL
3627 MMSL
4675 MMSL
4678 MMSL
4679 MMSL
4680 MMSL
4769 MMSL
4799 MMSL
72164 MMSL
d00046 MMSL
002755 NDDF
002758 NDDF
002759 NDDF
002760 NDDF
30427009 SNOMEDCT_US
372694001 SNOMEDCT_US
39152007 SNOMEDCT_US
698006 SNOMEDCT_US
83981000 SNOMEDCT_US
96032005 SNOMEDCT_US
96033000 SNOMEDCT_US
4501-00-2 SECONDARY_CAS_RN
7704-67-8 SECONDARY_CAS_RN
C025000 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 0093-5571 TABLET, FILM COATED 250 mg ORAL ANDA 23 sections
Erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 0093-5572 TABLET, FILM COATED 500 mg ORAL ANDA 23 sections
Erythrocin Lactobionate HUMAN PRESCRIPTION DRUG LABEL 1 0409-6482 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS NDA 13 sections
Erythrocin Lactobionate HUMAN PRESCRIPTION DRUG LABEL 1 0409-6482 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS NDA 13 sections
Erythrocin Stearate HUMAN PRESCRIPTION DRUG LABEL 1 10544-594 TABLET, FILM COATED 250 mg ORAL ANDA 23 sections
Erythrocin Stearate HUMAN PRESCRIPTION DRUG LABEL 1 10544-595 TABLET, FILM COATED 500 mg ORAL ANDA 23 sections
ERYTHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 13668-586 TABLET, DELAYED RELEASE 250 mg ORAL ANDA 25 sections
ERYTHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 13668-587 TABLET, DELAYED RELEASE 333 mg ORAL ANDA 25 sections
ERYTHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 13668-588 TABLET, DELAYED RELEASE 500 mg ORAL ANDA 25 sections
Erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 13668-606 TABLET, COATED 250 mg ORAL ANDA 14 sections
Erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 13668-607 TABLET, COATED 500 mg ORAL ANDA 14 sections
Erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 13985-605 OINTMENT 5 mg OPHTHALMIC ANDA 18 sections
ERYTHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-088 CAPSULE, DELAYED RELEASE 250 mg ORAL ANDA 22 sections
ERY-TAB HUMAN PRESCRIPTION DRUG LABEL 1 16590-089 TABLET, DELAYED RELEASE 333 mg ORAL ANDA 27 sections
ERYTHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-090 OINTMENT 5 mg OPHTHALMIC ANDA 9 sections
ERYTHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-091 TABLET, FILM COATED 250 mg ORAL ANDA 17 sections
Erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 17478-070 OINTMENT 5 mg OPHTHALMIC ANDA 19 sections
Erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 21695-173 OINTMENT 5 mg OPHTHALMIC ANDA 15 sections
ERYTHROMYCIN Base Filmtab HUMAN PRESCRIPTION DRUG LABEL 1 21695-387 TABLET, FILM COATED 250 mg ORAL ANDA 24 sections
ERYTHROMYCIN Base Filmtab HUMAN PRESCRIPTION DRUG LABEL 1 21695-389 TABLET, FILM COATED 500 mg ORAL ANDA 24 sections
ERY-TAB HUMAN PRESCRIPTION DRUG LABEL 1 21695-457 TABLET, DELAYED RELEASE 333 mg ORAL ANDA 23 sections
Erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 24208-910 OINTMENT 5 mg OPHTHALMIC ANDA 9 sections
Erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 24338-102 TABLET, FILM COATED 250 mg ORAL ANDA 27 sections
Erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 24338-104 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
ERYTHROMYCIN HUMAN PRESCRIPTION DRUG LABEL 1 24338-120 CAPSULE, DELAYED RELEASE 250 mg ORAL ANDA 27 sections
ERY-TAB HUMAN PRESCRIPTION DRUG LABEL 1 24338-122 TABLET, DELAYED RELEASE 250 mg ORAL ANDA 27 sections
ERY-TAB HUMAN PRESCRIPTION DRUG LABEL 1 24338-124 TABLET, DELAYED RELEASE 333 mg ORAL ANDA 27 sections
ERY-TAB HUMAN PRESCRIPTION DRUG LABEL 1 24338-126 TABLET, DELAYED RELEASE 500 mg ORAL ANDA 27 sections
ERY-TAB HUMAN PRESCRIPTION DRUG LABEL 1 42549-535 TABLET, DELAYED RELEASE 333 mg ORAL ANDA 27 sections
erythromycin HUMAN PRESCRIPTION DRUG LABEL 1 42571-384 SOLUTION 20 mg TOPICAL ANDA 18 sections