sulfadimidine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2502 57-68-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfadimidine
  • sulfamethazine
  • sulfadimerazine
  • sulfadimethyldiazine
  • sulfamethazine sodium
  • sulfamethazine sodium salt
A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.
  • Molecular weight: 278.33
  • Formula: C12H14N4O2S
  • CLOGP: 1.10
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 97.97
  • ALOGS: -3.08
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 153.98 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 86.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Aug. 16, 1949 FDA LEDERLE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01EB03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Short-acting sulfonamides
ATC J01EE05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:35441 anti-infective drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:50502 dihydropteroate synthase inhibitor
CHEBI has role CHEBI:50903 cancerogene
CHEBI has role CHEBI:52214 ligands
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Third trimester pregnancy contraindication 41587001
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Disease of liver contraindication 235856003 DOID:409
Breastfeeding (mother) contraindication 413712001
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.24 acidic
pKa2 2.88 Basic
pKa3 2.27 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lactoylglutathione lyase Enzyme WOMBAT-PK
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4017499 VUID
N0000145884 NUI
D02436 KEGG_DRUG
1981-58-4 SECONDARY_CAS_RN
4017499 VANDF
C0038686 UMLSCUI
CHEBI:102265 CHEBI
CHEMBL446 ChEMBL_ID
DB01582 DRUGBANK_ID
5327 PUBCHEM_CID
1068 INN_ID
48U51W007F UNII
10178 RXNORM
NOCODE MMSL
002817 NDDF
324417001 SNOMEDCT_US
40036000 SNOMEDCT_US
D013418 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None