sulfapyridine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2524 144-83-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfapyridine
  • piridazol
  • pirodazole
  • plurazol
  • pyridazol
  • streptosilpyridine
  • sulfidin
  • sulfidine
  • sulphapyridine
Antibacterial, potentially toxic, used to treat certain skin diseases.
  • Molecular weight: 249.29
  • Formula: C11H11N3O2S
  • CLOGP: 0.84
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 85.08
  • ALOGS: -3.03
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 9, 1939 FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01EB04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Short-acting sulfonamides
MeSH PA D000890 Anti-Infective Agents
MeSH PA D003879 Dermatologic Agents
CHEBI has role CHEBI:35441 anti-infective drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50177 dermatological agent
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dermatitis herpetiformis indication 111196000 DOID:8505
Subcorneal pustular dermatosis off-label use 25147002 DOID:8508
Pyoderma gangrenosum off-label use 74578003 DOID:8553
Pemphigoid off-label use 86142006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.21 acidic
pKa2 2.54 Basic
pKa3 1.48 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL
Dihydropteroate synthase type-1 Enzyme WOMBAT-PK

External reference:

IDSource
4017496 VUID
N0000145881 NUI
D02434 KEGG_DRUG
4017496 VANDF
C0038710 UMLSCUI
CHEBI:132842 CHEBI
SFY PDB_CHEM_ID
CHEMBL700 ChEMBL_ID
DB00891 DRUGBANK_ID
D013427 MESH_DESCRIPTOR_UI
4165 INN_ID
5336 PUBCHEM_CID
Y5V2N1KE8U UNII
10188 RXNORM
NOCODE MMSL
002829 NDDF
27082000 SNOMEDCT_US

Pharmaceutical products:

None