sulfapyridine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-infectives, sulfonamides | 2524 | 144-83-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Antibacterial, potentially toxic, used to treat certain skin diseases.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 9, 1939 | FDA | LILLY |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01EB04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Short-acting sulfonamides |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D003879 | Dermatologic Agents |
| CHEBI has role | CHEBI:35441 | antiinfective agents |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:50177 | dermatologic agent |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
| CHEBI has role | CHEBI:88188 | allergenic drug |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dermatitis herpetiformis | indication | 111196000 | DOID:8505 |
| Subcorneal pustular dermatosis | off-label use | 25147002 | DOID:8508 |
| Pyoderma gangrenosum | off-label use | 74578003 | DOID:8553 |
| Pemphigoid | off-label use | 86142006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.21 | acidic |
| pKa2 | 2.54 | Basic |
| pKa3 | 1.48 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Dihydropteroate synthase | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| Dihydropteroate synthase type-1 | Enzyme | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4017496 | VUID |
| N0000145881 | NUI |
| D02434 | KEGG_DRUG |
| 4017496 | VANDF |
| C0038710 | UMLSCUI |
| CHEBI:132842 | CHEBI |
| SFY | PDB_CHEM_ID |
| CHEMBL700 | ChEMBL_ID |
| DB00891 | DRUGBANK_ID |
| D013427 | MESH_DESCRIPTOR_UI |
| 5336 | PUBCHEM_CID |
| 12698 | IUPHAR_LIGAND_ID |
| 4165 | INN_ID |
| Y5V2N1KE8U | UNII |
| 10188 | RXNORM |
| NOCODE | MMSL |
| 002829 | NDDF |
| 27082000 | SNOMEDCT_US |
Pharmaceutical products:
None