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sulfapyridine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-infectives, sulfonamides | 2524 | 144-83-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Antibacterial, potentially toxic, used to treat certain skin diseases.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 90 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.101 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.881 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 42.170 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 1.858 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 65.010 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 77.700 | % | High | 1 |
| herg | hERG pIC50 | 3.731 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.667 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.105 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 63.420 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK1,MAPK12,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 50 | |||
| kinase-selectivity-class | ACVR2A,ACVR2B,AURKA,AXL,CAMK2D,CDK1,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,FLT3,GRK2,JAK1,MAP2K3,MAP2K6,MAP3K21,MAP4K1,MAPK7,MARK4,PDK4,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 | 31 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 2.133 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 4.764 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 77.250 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 2.523 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 76.640 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 1.549 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 96.210 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 51.090 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 824.138 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 9, 1939 | FDA | LILLY |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01EB04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Short-acting sulfonamides |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D003879 | Dermatologic Agents |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:50177 | dermatologic drug |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
| CHEBI has role | CHEBI:88188 | drug allergen |
Related Drugs by ATC class:
J01EB Short-acting sulfonamides 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dermatitis herpetiformis | indication | 111196000 | DOID:8505 |
| Subcorneal pustular dermatosis | off-label use | 25147002 | DOID:8508 |
| Pyoderma gangrenosum | off-label use | 74578003 | DOID:8553 |
| Pemphigoid | off-label use | 86142006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.21 | acidic |
| pKa2 | 2.54 | Basic |
| pKa3 | 1.48 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Dihydropteroate synthase | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| Dihydropteroate synthase type-1 | Enzyme | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4017496 | VUID |
| N0000145881 | NUI |
| D02434 | KEGG_DRUG |
| 4017496 | VANDF |
| C0038710 | UMLSCUI |
| CHEBI:132842 | CHEBI |
| SFY | PDB_CHEM_ID |
| CHEMBL700 | ChEMBL_ID |
| DB00891 | DRUGBANK_ID |
| D013427 | MESH_DESCRIPTOR_UI |
| 5336 | PUBCHEM_CID |
| 12698 | IUPHAR_LIGAND_ID |
| 4165 | INN_ID |
| Y5V2N1KE8U | UNII |
| 10188 | RXNORM |
| NOCODE | MMSL |
| 002829 | NDDF |
| 27082000 | SNOMEDCT_US |
Pharmaceutical products:
None