pseudoephedrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetics 2326 90-82-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pseudoephedrine
  • (+)-Pseudoephedrine
  • pseudophedrine sulphate
  • pseudoephedrine hydrochloride
  • pseudoephedrine sulfate
  • pseudoephedrine HCl
  • pseudoephedrine polistirex
A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
  • Molecular weight: 165.24
  • Formula: C10H15NO
  • CLOGP: 0.89
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 32.26
  • ALOGS: -1.30
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.24 g O
0.24 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 43 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 100 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK3,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,SIK3,SYK,TEK,TGFBR1,ZAP70 33
kinase-selectivity-class AXL,EIF2AK3,GRK2,PDK4 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Oct. 18, 1963 FDA SCHERING PLOUGH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 3055.38 21.79 4883 340234 321981 89961349
Systemic lupus erythematosus 2911.33 21.79 5054 340063 356842 89926488
Glossodynia 2732.32 21.79 4604 340513 317175 89966155
Wound 2715.69 21.79 4442 340675 298538 89984792
Pericarditis 2703.72 21.79 4166 340951 265985 90017345
Hand deformity 2692.81 21.79 4372 340745 291990 89991340
Anti-cyclic citrullinated peptide antibody positive 2251.62 21.79 3565 341552 232868 90050462
Synovitis 2116.30 21.79 4181 340936 325571 89957759
Duodenal ulcer perforation 2001.64 21.79 3260 341857 218028 90065302
Discomfort 1925.65 21.79 3614 341503 270721 90012609
Helicobacter infection 1889.92 21.79 3221 341896 223629 90059701
Swelling 1822.66 21.79 4547 340570 414511 89868819
Arthropathy 1809.77 21.79 4176 340941 362066 89921264
Abdominal discomfort 1779.76 21.79 4889 340228 472439 89810891
Alopecia 1580.70 21.79 4797 340320 490274 89793056
Hepatic enzyme increased 1451.84 21.79 3803 341314 356933 89926397
Folliculitis 1392.79 21.79 2660 342457 201693 90081637
Rheumatoid factor positive 1384.87 21.79 2404 342713 169246 90114084
Infusion related reaction 1357.98 21.79 4069 341048 412711 89870619
Rheumatic fever 1343.00 21.79 2226 342891 150895 90132435
Contraindicated product administered 1304.00 21.79 3391 341726 316748 89966582
Irritable bowel syndrome 1292.04 21.79 2600 342517 204848 90078482
Muscle injury 1228.84 21.79 2320 342797 174334 90108996
Type 2 diabetes mellitus 1179.12 21.79 2474 342643 200770 90082560
Blister 1156.06 21.79 2814 342303 252184 90031146
Maternal exposure during pregnancy 1087.74 21.79 3425 341692 356638 89926692
Swollen joint count increased 1070.58 21.79 1687 343430 109519 90173811
Impaired healing 1052.35 21.79 2576 342541 231623 90051707
Hypersensitivity 1043.95 21.79 3947 341170 450730 89832600
Sleep disorder due to general medical condition, insomnia type 1033.04 21.79 1799 343318 126895 90156435
Acute kidney injury 960.55 21.79 67 345050 320320 89963010
Anaemia 945.54 21.79 116 345001 352686 89930644
Blood cholesterol increased 907.82 21.79 2263 342854 205749 90077581
Joint swelling 901.81 21.79 4048 341069 499252 89784078
Drug interaction 880.16 21.79 41 345076 276412 90006918
Psoriatic arthropathy 862.16 21.79 2353 342764 225982 90057348
Therapeutic product effect decreased 817.01 21.79 2618 342499 274953 90008377
Injury 800.81 21.79 2089 343028 195260 90088070
Stomatitis 798.60 21.79 2580 342537 272118 90011212
Liver injury 793.35 21.79 1902 343215 168665 90114665
Ill-defined disorder 782.02 21.79 1988 343129 182903 90100427
Hypotension 761.55 21.79 156 344961 325241 89958089
Product use issue 748.64 21.79 2855 342262 327064 89956266
Drug intolerance 731.11 21.79 3505 341612 444086 89839244
Toxicity to various agents 712.07 21.79 120 344997 287726 89995604
Fall 705.77 21.79 486 344631 481324 89802006
Death 692.32 21.79 443 344674 456108 89827222
Neutropenia 688.77 21.79 42 345075 224862 90058468
Lower respiratory tract infection 673.73 21.79 2293 342824 248366 90034964
Fibromyalgia 633.54 21.79 1975 343142 204294 90079036
Cough 625.26 21.79 312 344805 368650 89914680
Urinary tract infection 604.22 21.79 205 344912 305427 89977903
General physical health deterioration 603.52 21.79 2814 342303 352301 89931029
Treatment failure 576.85 21.79 2489 342628 301439 89981891
Nausea 570.24 21.79 2241 342876 1108075 89175255
Constipation 559.59 21.79 185 344932 280210 90003120
Back pain 555.98 21.79 256 344861 316919 89966411
Joint range of motion decreased 545.94 21.79 1432 343685 134211 90149119
Facet joint syndrome 531.05 21.79 1164 343953 97225 90186105
Lip dry 523.10 21.79 1175 343942 99780 90183550
Somnolence 519.54 21.79 86 345031 208998 90074332
Erythema 515.67 21.79 120 344997 229126 90054204
Product dose omission issue 513.42 21.79 234 344883 291453 89991877
Febrile neutropenia 498.91 21.79 25 345092 158324 90125006
Mobility decreased 490.71 21.79 2073 343044 248661 90034669
Gastrointestinal disorder 485.99 21.79 2101 343016 254586 90028744
Sepsis 484.13 21.79 58 345059 179756 90103574
Musculoskeletal stiffness 475.30 21.79 2311 342806 294221 89989109
Disease progression 474.20 21.79 31 345086 156584 90126746
Dehydration 457.21 21.79 92 345025 194355 90088975
Peripheral venous disease 450.77 21.79 991 344126 82930 90200400
Deep vein thrombosis postoperative 425.16 21.79 875 344242 69934 90213396
Pancytopenia 406.24 21.79 11 345106 120252 90163078
Hyponatraemia 405.55 21.79 26 345091 133512 90149818
Wound infection 402.48 21.79 1098 344019 105304 90178026
Injection site pain 394.41 21.79 89 345028 173610 90109720
Intentional product use issue 388.16 21.79 1746 343371 215146 90068184
Haemoglobin decreased 384.14 21.79 75 345042 161881 90121449
Diarrhoea 377.31 21.79 2071 343046 937119 89346211
White blood cell count decreased 376.68 21.79 87 345030 167022 90116308
Thrombocytopenia 374.16 21.79 163 344954 208562 90074768
Hip arthroplasty 372.58 21.79 867 344250 75341 90207989
Blood pressure increased 369.71 21.79 144 344973 197073 90086257
Sleep disorder 364.76 21.79 1608 343509 196422 90086908
Platelet count decreased 361.80 21.79 47 345070 136922 90146408
Renal failure 358.25 21.79 40 345077 130967 90152363
Contusion 355.50 21.79 1891 343226 249325 90034005
Seizure 353.02 21.79 75 345042 152554 90130776
Hyperhidrosis 345.44 21.79 53 345064 136252 90147078
Tremor 344.72 21.79 80 345037 153093 90130237
Breast cancer stage III 342.14 21.79 894 344223 83553 90199777
Sinusitis 338.87 21.79 2352 342765 340736 89942594
Grip strength decreased 338.86 21.79 944 344173 91632 90191698
Autoimmune disorder 338.50 21.79 839 344278 75905 90207425
Road traffic accident 335.14 21.79 1036 344081 106590 90176740
Hypercholesterolaemia 329.91 21.79 988 344129 99904 90183426
Rash 328.77 21.79 4541 340576 791559 89491771
Malignant neoplasm progression 326.92 21.79 20 345097 106850 90176480
Syncope 326.30 21.79 56 345061 132607 90150723
C-reactive protein abnormal 325.58 21.79 1147 343970 126282 90157048
Myalgia 324.74 21.79 130 344987 174995 90108335
Renal impairment 324.70 21.79 19 345098 105402 90177928
Cardiac failure 324.67 21.79 24 345093 109472 90173858
Atrial fibrillation 322.97 21.79 59 345058 133552 90149778
Confusional state 320.85 21.79 2541 342576 383664 89899666
Infection 320.01 21.79 2417 342700 359677 89923653
Obesity 316.90 21.79 1003 344114 104504 90178826
Sciatica 311.13 21.79 971 344146 100411 90182919
Bursitis 310.89 21.79 1155 343962 130499 90152831
Alanine aminotransferase increased 306.85 21.79 43 345074 118295 90165035
Completed suicide 306.75 21.79 86 345031 144972 90138358
Neuropathy peripheral 303.37 21.79 74 345043 136896 90146434
Wheezing 298.70 21.79 1735 343382 236345 90046985
Dislocation of vertebra 296.06 21.79 657 344460 55311 90228019
Pulmonary fibrosis 295.88 21.79 992 344125 106511 90176819
Weight increased 292.28 21.79 2646 342471 415281 89868049
Lower limb fracture 291.76 21.79 847 344270 84166 90199164
Nasopharyngitis 291.11 21.79 2590 342527 404514 89878816
Gait inability 289.41 21.79 1215 343902 145241 90138089
Cerebrovascular accident 289.18 21.79 59 345058 123474 90159856
Live birth 288.85 21.79 806 344311 78301 90205029
Adjustment disorder with depressed mood 288.78 21.79 656 344461 56097 90227233
Night sweats 286.96 21.79 1109 344008 127657 90155673
Blood creatinine increased 282.19 21.79 29 345088 101357 90181973
Knee arthroplasty 281.86 21.79 825 344292 82357 90200973
Chest discomfort 279.90 21.79 89 345028 138276 90145054
COVID-19 277.92 21.79 148 344969 168695 90114635
Inappropriate schedule of product administration 275.21 21.79 113 345004 149820 90133510
Feeling abnormal 271.75 21.79 149 344968 167086 90116244
Aspartate aminotransferase increased 270.22 21.79 36 345081 102901 90180429
Oxygen saturation decreased 269.61 21.79 43 345074 107440 90175890
Influenza 267.12 21.79 98 345019 139166 90144164
Respiratory failure 266.14 21.79 62 345055 118356 90164974
Blepharospasm 264.66 21.79 625 344492 54820 90228510
X-ray abnormal 264.05 21.79 554 344563 44870 90238460
Intentional overdose 263.35 21.79 26 345091 93808 90189522
Prescribed overdose 259.97 21.79 891 344226 96734 90186596
Bradycardia 258.56 21.79 15 345102 83832 90199498
Heart rate increased 257.96 21.79 57 345060 112845 90170485
Myocardial infarction 257.84 21.79 46 345071 105926 90177404
Adverse event 256.52 21.79 1005 344112 116413 90166917
Herpes zoster 255.99 21.79 30 345087 94614 90188716
Pain 255.94 21.79 5261 339856 991080 89292250
Balance disorder 254.71 21.79 34 345083 97046 90186284
Blood glucose increased 253.17 21.79 32 345085 95214 90188116
Lupus vulgaris 250.88 21.79 540 344577 44519 90238811
Dry mouth 247.04 21.79 1366 343751 182693 90100637
Onychomadesis 246.71 21.79 543 344574 45455 90237875
Palpitations 244.61 21.79 107 345010 136621 90146709
Injection site erythema 239.12 21.79 43 345074 98459 90184871
Vision blurred 237.67 21.79 63 345054 110230 90173100
Pulmonary embolism 234.63 21.79 102 345015 130718 90152612
Cardiac arrest 233.72 21.79 56 345061 104879 90178451
Chills 233.41 21.79 105 345012 131876 90151454
Multiple organ dysfunction syndrome 231.70 21.79 6 345111 68330 90215000
Prescribed underdose 231.51 21.79 720 344397 74299 90209031
Retinitis 229.33 21.79 474 344643 37984 90245346
Electrocardiogram QT prolonged 223.30 21.79 13 345104 72443 90210887
Hyperkalaemia 222.96 21.79 5 345112 64959 90218371
Oropharyngeal pain 222.69 21.79 80 345037 115107 90168223
Gastrointestinal haemorrhage 222.12 21.79 38 345079 90210 90193120
Hypoglycaemia 220.04 21.79 11 345106 69837 90213493
Osteoarthritis 218.47 21.79 1384 343733 194346 90088984
Hypoaesthesia 214.70 21.79 1980 343137 312230 89971100
Suicide attempt 213.94 21.79 20 345097 75379 90207951
Depressed level of consciousness 212.81 21.79 17 345100 72767 90210563
Drug abuse 210.96 21.79 31 345086 82316 90201014
Dysphagia 205.42 21.79 85 345032 112193 90171137
Peripheral swelling 204.78 21.79 2439 342678 410667 89872663
Lung disorder 204.18 21.79 1117 344000 148766 90134564
Flushing 203.53 21.79 44 345073 88447 90194883
Neutrophil count decreased 200.26 21.79 20 345097 71512 90211818
Coma 198.99 21.79 22 345095 72610 90210720
Anti-cyclic citrullinated peptide antibody 195.70 21.79 363 344754 26858 90256472
Blood pressure decreased 194.65 21.79 27 345090 74868 90208462
Blood pressure systolic increased 194.58 21.79 6 345111 58339 90224991
Hypokalaemia 193.21 21.79 131 344986 130985 90152345
Leukopenia 192.90 21.79 71 345046 100639 90182691
Angioedema 190.11 21.79 15 345102 64861 90218469
Nail disorder 187.92 21.79 573 344544 58494 90224836
Rheumatoid arthritis 187.24 21.79 2158 342959 360456 89922874
Cellulitis 186.05 21.79 58 345059 91279 90192051
Mucosal inflammation 185.01 21.79 8 345109 57617 90225713
Onychomycosis 184.57 21.79 427 344690 36949 90246381
Wrong technique in product usage process 180.92 21.79 28 345089 71543 90211787
Urticaria 179.67 21.79 1901 343216 310833 89972497
Vertigo 179.48 21.79 26 345091 69785 90213545
Pleural effusion 175.86 21.79 104 345013 111887 90171443
C-reactive protein 175.86 21.79 377 344740 30990 90252340
Epistaxis 173.48 21.79 54 345063 85071 90198259
Abdominal pain 173.16 21.79 846 344271 394875 89888455
Skin exfoliation 172.97 21.79 26 345091 67887 90215443
Dyspnoea exertional 172.36 21.79 33 345084 72255 90211075
Dry skin 172.24 21.79 60 345057 88013 90195317
Incorrect dose administered 172.12 21.79 44 345073 78886 90204444
Abortion spontaneous 171.92 21.79 8 345109 54048 90229282
Rhabdomyolysis 171.92 21.79 5 345112 51251 90232079
Inflammation 171.71 21.79 1217 343900 177375 90105955
Metabolic acidosis 171.54 21.79 10 345107 55666 90227664
Oedema 169.38 21.79 1324 343793 198971 90084359
Lactic acidosis 168.97 21.79 5 345112 50458 90232872
Loss of consciousness 167.35 21.79 172 344945 140066 90143264
Suicidal ideation 167.27 21.79 38 345079 73817 90209513
Influenza like illness 166.33 21.79 50 345067 80561 90202769
Interstitial lung disease 165.83 21.79 43 345074 76362 90206968
Taste disorder 165.81 21.79 564 344553 60982 90222348
Cystitis 164.39 21.79 28 345089 66690 90216640
Swelling face 163.31 21.79 53 345064 81299 90202031
Stress 161.69 21.79 54 345063 81341 90201989
Cardiac failure congestive 161.65 21.79 87 345030 98607 90184723
Exostosis 159.36 21.79 505 344612 52629 90230701
Cognitive disorder 158.62 21.79 35 345082 69372 90213958
Overdose 156.84 21.79 223 344894 157486 90125844
Cataract 155.65 21.79 41 345076 72051 90211279
Lupus-like syndrome 155.52 21.79 474 344643 48372 90234958
Heart rate decreased 152.31 21.79 14 345103 53491 90229839
Laryngitis 150.96 21.79 481 344636 50272 90233058
Thrombosis 150.11 21.79 46 345071 73205 90210125
Off label use 150.04 21.79 3132 341985 1099120 89184210
Deep vein thrombosis 149.71 21.79 81 345036 91539 90191791
Cardio-respiratory arrest 148.07 21.79 30 345087 63110 90220220
Sedation 147.35 21.79 9 345108 48162 90235168
Agitation 147.08 21.79 37 345080 67061 90216269
Hepatic function abnormal 146.73 21.79 7 345110 46281 90237049
Blood bilirubin increased 146.68 21.79 4 345113 43466 90239864
Blood pressure fluctuation 145.82 21.79 15 345102 52398 90230932
Bone erosion 145.58 21.79 489 344628 52532 90230798
Lethargy 143.96 21.79 32 345085 63107 90220223
Dysarthria 140.74 21.79 20 345097 54462 90228868
Neoplasm progression 140.14 21.79 7 345110 44479 90238851
Liver disorder 139.91 21.79 865 344252 120404 90162926
Colitis 139.63 21.79 46 345071 69896 90213434
Haematochezia 139.20 21.79 48 345069 70865 90212465
Pulmonary oedema 138.49 21.79 33 345084 62047 90221283
Skin ulcer 137.59 21.79 15 345102 50060 90233270
Burning sensation 137.15 21.79 36 345081 63416 90219914
Bone pain 136.21 21.79 34 345083 61949 90221381
Hyperglycaemia 135.74 21.79 17 345100 50953 90232377
Hypoxia 135.37 21.79 53 345064 72346 90210984
Premature delivery 132.95 21.79 3 345114 38759 90244571
Therapy interrupted 132.75 21.79 17 345100 50091 90233239
Disorientation 132.69 21.79 9 345108 44105 90239225
Septic shock 132.35 21.79 78 345039 84082 90199248
Hallucination 132.35 21.79 43 345074 65916 90217414
Ascites 131.94 21.79 14 345103 47726 90235604
Multiple sclerosis relapse 130.98 21.79 21 345096 52284 90231046
Swollen tongue 130.88 21.79 12 345105 45944 90237386
Gamma-glutamyltransferase increased 129.93 21.79 3 345114 37949 90245381
Drug ineffective for unapproved indication 129.29 21.79 46 345071 66598 90216732
Injection site swelling 129.24 21.79 34 345083 59805 90223525
Walking aid user 128.81 21.79 361 344756 35145 90248185
Liver function test abnormal 126.01 21.79 21 345096 50824 90232506
Hepatic failure 125.95 21.79 6 345111 39722 90243608
Injection site pruritus 125.36 21.79 26 345091 53808 90229522
Breast cancer 125.12 21.79 26 345091 53735 90229595
Hypothyroidism 125.08 21.79 25 345092 53102 90230228
Drug reaction with eosinophilia and systemic symptoms 124.96 21.79 10 345107 42748 90240582
Encephalopathy 124.89 21.79 15 345102 46429 90236901
Haemorrhage 124.50 21.79 54 345063 69315 90214015
Rash erythematous 124.49 21.79 46 345071 65058 90218272
Rash maculo-papular 124.15 21.79 8 345109 40925 90242405
Rhinorrhoea 122.57 21.79 94 345023 88222 90195108
Migraine 122.52 21.79 1185 343932 189207 90094123
Seronegative arthritis 122.21 21.79 236 344881 17998 90265332
Device expulsion 121.07 21.79 9 345108 40877 90242453
Breast cancer stage II 120.17 21.79 351 344766 34983 90248347
Pneumonitis 119.43 21.79 14 345103 44156 90239174
Femur fracture 118.84 21.79 17 345100 46065 90237265
Weight decreased 118.54 21.79 903 344214 379007 89904323
Dysphonia 118.25 21.79 46 345071 63038 90220292
Illness 117.96 21.79 84 345033 81885 90201445
Osteonecrosis of jaw 117.54 21.79 8 345109 39095 90244235
Speech disorder 117.13 21.79 17 345100 45568 90237762
Drug eruption 116.79 21.79 4 345113 35403 90247927
Transient ischaemic attack 115.96 21.79 14 345103 43162 90240168
Red blood cell count decreased 115.19 21.79 19 345098 46332 90236998
Mouth ulceration 115.02 21.79 10 345107 39964 90243366
Pneumonia 114.56 21.79 1725 343392 636334 89646996
Blood alkaline phosphatase increased 114.51 21.79 22 345095 48057 90235273
Eczema 114.26 21.79 30 345087 52840 90230490
Asthenia 113.83 21.79 1393 343724 532358 89750972
Orthostatic hypotension 113.74 21.79 13 345104 41814 90241516
Hepatotoxicity 113.46 21.79 19 345098 45823 90237507
Skin discolouration 112.77 21.79 17 345100 44298 90239032
Lymphocyte count decreased 112.07 21.79 5 345112 35045 90248285
Intentional product misuse 111.37 21.79 106 345011 89498 90193832
Pulmonary hypertension 111.27 21.79 15 345102 42508 90240822
Memory impairment 110.83 21.79 1194 343923 196050 90087280
Transaminases increased 110.66 21.79 8 345109 37184 90246146
Hypertension 110.28 21.79 2396 342721 455136 89828194
Aphasia 109.92 21.79 16 345101 42796 90240534
Depressed mood 109.49 21.79 28 345089 50194 90233136
Lymphadenopathy 108.90 21.79 21 345096 45754 90237576
Hot flush 108.85 21.79 45 345072 59443 90223887
Injection site bruising 108.72 21.79 32 345085 52275 90231055
Full blood count abnormal 108.53 21.79 8 345109 36589 90246741
Pancreatitis acute 108.19 21.79 3 345114 32112 90251218
International normalised ratio increased 107.84 21.79 24 345093 47292 90236038
Hypomagnesaemia 107.80 21.79 7 345110 35581 90247749
Cardiac disorder 107.38 21.79 41 345076 56831 90226499
Dry eye 107.34 21.79 43 345074 57888 90225442
Drug tolerance decreased 107.19 21.79 317 344800 31813 90251517
Angina pectoris 106.91 21.79 12 345105 39148 90244182
Hypercalcaemia 105.94 21.79 6 345111 34234 90249096
Melaena 104.95 21.79 7 345110 34790 90248540
Diverticulitis 104.86 21.79 22 345095 45165 90238165
Haematoma 104.04 21.79 13 345104 39035 90244295
Pneumonia aspiration 103.50 21.79 16 345101 40924 90242406
Localised infection 103.48 21.79 6 345111 33556 90249774
Musculoskeletal pain 103.43 21.79 1052 344065 170199 90113131
Throat irritation 102.66 21.79 29 345088 48666 90234664
Blood creatine phosphokinase increased 102.16 21.79 7 345110 34016 90249314
Productive cough 101.97 21.79 86 345031 76977 90206353
Hepatic steatosis 101.68 21.79 11 345106 36934 90246396
Product prescribing error 100.88 21.79 3 345114 30142 90253188
Dyspnoea 100.54 21.79 2571 342546 878384 89404946
Serotonin syndrome 100.01 21.79 13 345104 37874 90245456
Altered state of consciousness 99.20 21.79 5 345112 31527 90251803
Chronic kidney disease 98.46 21.79 34 345083 50157 90233173
Cerebral haemorrhage 98.35 21.79 9 345108 34513 90248817
Hypophagia 98.14 21.79 11 345106 35926 90247404
Anaphylactic reaction 98.14 21.79 113 345004 87411 90195919
Stevens-Johnson syndrome 98.03 21.79 3 345114 29373 90253957
Tinnitus 97.95 21.79 22 345095 43080 90240250
Dyskinesia 97.74 21.79 12 345105 36522 90246808
Cholelithiasis 97.24 21.79 39 345078 52467 90230863
Tachycardia 96.63 21.79 294 344823 157379 90125951
Plasma cell myeloma 96.56 21.79 19 345098 40809 90242521
Headache 96.54 21.79 2525 342592 860221 89423109
Hepatocellular injury 96.48 21.79 3 345114 28955 90254375
Anaphylactic shock 96.42 21.79 6 345111 31611 90251719
Unevaluable event 96.37 21.79 44 345073 54804 90228526
Pericardial effusion 96.36 21.79 13 345104 36820 90246510
Skin lesion 95.85 21.79 14 345103 37351 90245979
Foetal exposure during pregnancy 95.55 21.79 23 345094 42952 90240378
Product quality issue 95.38 21.79 572 344545 78753 90204577
Joint dislocation 95.21 21.79 379 344738 44203 90239127
Pain in jaw 95.01 21.79 32 345085 47953 90235377
Dysgeusia 94.18 21.79 41 345076 52519 90230811
Disturbance in attention 94.00 21.79 31 345086 47078 90236252
Jaundice 93.93 21.79 8 345109 32509 90250821
Eye pain 93.68 21.79 26 345091 44142 90239188
Epilepsy 93.31 21.79 584 344533 81622 90201708
Drug level increased 92.05 21.79 3 345114 27759 90255571
Basal cell carcinoma 91.74 21.79 10 345107 33379 90249951
Arrhythmia 91.52 21.79 24 345093 42308 90241022
Diabetes mellitus 91.37 21.79 68 345049 64807 90218523
Staphylococcal infection 91.32 21.79 35 345082 48404 90234926
Vomiting 91.11 21.79 2296 342821 785997 89497333
Blood potassium decreased 90.79 21.79 34 345083 47693 90235637
Back injury 90.61 21.79 385 344732 46237 90237093
Hepatic cirrhosis 90.55 21.79 478 344639 62775 90220555
Porphyria acute 90.55 21.79 207 344910 17768 90265562
Surgery 90.52 21.79 29 345088 44858 90238472
Pallor 89.52 21.79 12 345105 34153 90249177
Metastases to liver 89.27 21.79 5 345112 28802 90254528
Lip swelling 89.18 21.79 19 345098 38591 90244739
Shock 89.17 21.79 5 345112 28773 90254557
Presyncope 88.74 21.79 9 345108 31796 90251534
Blood calcium decreased 88.36 21.79 7 345110 30175 90253155
Pregnancy 88.22 21.79 468 344649 61579 90221751
Mental status changes 88.11 21.79 30 345087 44649 90238681
Haematemesis 88.00 21.79 12 345105 33714 90249616
Restlessness 87.97 21.79 15 345102 35705 90247625
Therapy cessation 87.96 21.79 16 345101 36345 90246985
Gastritis 87.77 21.79 25 345092 41728 90241602
Cytomegalovirus infection 87.76 21.79 3 345114 26599 90256731
Generalised tonic-clonic seizure 87.42 21.79 14 345103 34889 90248441
Acute myocardial infarction 87.38 21.79 14 345103 34876 90248454
Nephrolithiasis 86.83 21.79 39 345078 49046 90234284
Delirium 86.58 21.79 687 344430 103672 90179658
Palmar-plantar erythrodysaesthesia syndrome 86.42 21.79 5 345112 28018 90255312
Acute respiratory distress syndrome 85.84 21.79 6 345111 28680 90254650
Subcutaneous drug absorption impaired 85.55 21.79 171 344946 13374 90269956
Blood pressure diastolic decreased 85.21 21.79 4 345113 26822 90256508
Haematocrit decreased 84.40 21.79 27 345090 41805 90241525
Psychotic disorder 84.18 21.79 10 345107 31220 90252110
Ejection fraction decreased 83.11 21.79 4 345113 26249 90257081
Osteonecrosis 83.07 21.79 4 345113 26237 90257093
Nasal congestion 82.85 21.79 118 344999 83296 90200034
Foot deformity 82.81 21.79 447 344670 59204 90224126
Gastroenteritis 82.26 21.79 8 345109 29221 90254109
Premature baby 82.13 21.79 3 345114 25074 90258256
Disability 81.94 21.79 340 344777 40405 90242925
Dyspepsia 81.89 21.79 1132 343985 197028 90086302
Cerebral infarction 81.25 21.79 5 345112 26591 90256739
Accidental exposure to product 80.89 21.79 30 345087 42336 90240994
Renal disorder 80.83 21.79 22 345095 37837 90245493
Respiratory distress 80.62 21.79 24 345093 38922 90244408
Acute respiratory failure 79.28 21.79 32 345085 42886 90240444
Hemiparesis 79.17 21.79 13 345104 31806 90251524
Maternal exposure timing unspecified 79.01 21.79 226 344891 22257 90261073
Obstructive airways disorder 78.62 21.79 5 345112 25864 90257466
Fungal infection 78.49 21.79 32 345085 42629 90240701
Device dislocation 78.02 21.79 13 345104 31469 90251861
Neoplasm malignant 77.58 21.79 17 345100 33863 90249467
Product label confusion 76.75 21.79 226 344891 22624 90260706
Blood urea increased 76.63 21.79 12 345105 30401 90252929
Clostridium difficile colitis 75.98 21.79 7 345110 26699 90256631
Adverse drug reaction 75.84 21.79 728 344389 115973 90167357
Abdominal pain lower 75.82 21.79 12 345105 30165 90253165
Device related infection 75.44 21.79 6 345111 25780 90257550
Ocular hyperaemia 75.31 21.79 18 345099 33780 90249550
Haematuria 75.16 21.79 20 345097 34917 90248413
Flatulence 74.55 21.79 32 345085 41335 90241995
Urinary incontinence 74.47 21.79 25 345092 37541 90245789
Lymphopenia 74.04 21.79 3 345114 22878 90260452
Device issue 73.64 21.79 12 345105 29525 90253805
Cardiogenic shock 73.56 21.79 5 345112 24463 90258867
Dysuria 73.40 21.79 29 345088 39372 90243958
Rash pruritic 73.36 21.79 125 344992 82089 90201241
Viral infection 73.11 21.79 33 345084 41381 90241949
Vaginal haemorrhage 73.02 21.79 15 345102 31256 90252074
Blindness 72.89 21.79 8 345109 26560 90256770
Oral herpes 72.48 21.79 19 345098 33505 90249825
Ulcer haemorrhage 72.46 21.79 243 344874 26078 90257252
Leukocytosis 72.09 21.79 15 345102 30975 90252355
Irritability 71.98 21.79 23 345094 35639 90247691
Bacteraemia 71.90 21.79 3 345114 22297 90261033
Food allergy 71.63 21.79 7 345110 25471 90257859
Eating disorder 70.90 21.79 11 345106 28062 90255268
Candida infection 70.47 21.79 21 345096 34036 90249294
Eosinophilia 70.23 21.79 12 345105 28521 90254809
Haemoptysis 69.95 21.79 20 345097 33300 90250030
Hip fracture 69.17 21.79 20 345097 33057 90250273
Metastases to bone 69.16 21.79 8 345109 25497 90257833
Disseminated intravascular coagulation 69.10 21.79 3 345114 21535 90261795
Coronary artery disease 69.09 21.79 21 345096 33602 90249728
Pollakiuria 68.94 21.79 20 345097 32985 90250345
Sopor 68.69 21.79 7 345110 24637 90258693
Body temperature decreased 68.41 21.79 6 345111 23810 90259520
Hypervolaemia 68.15 21.79 20 345097 32737 90250593
Finger deformity 67.32 21.79 276 344841 32621 90250709
Skin disorder 66.78 21.79 28 345089 36678 90246652
Mental disorder 66.74 21.79 20 345097 32298 90251032
Pulmonary arterial hypertension 66.74 21.79 10 345107 26177 90257153
Acute hepatic failure 66.70 21.79 5 345112 22556 90260774
Diplopia 66.58 21.79 14 345103 28700 90254630
Gastric ulcer 66.56 21.79 12 345105 27436 90255894
Proteinuria 66.54 21.79 6 345111 23285 90260045
Coagulopathy 66.54 21.79 6 345111 23283 90260047
Liver function test increased 66.26 21.79 551 344566 84304 90199026
Aggression 66.12 21.79 11 345106 26657 90256673
Sinus tachycardia 65.91 21.79 14 345103 28499 90254831
Posterior reversible encephalopathy syndrome 65.91 21.79 5 345112 22334 90260996
Hallucination, visual 65.84 21.79 6 345111 23086 90260244
Therapy non-responder 65.73 21.79 803 344314 135901 90147429
Upper gastrointestinal haemorrhage 65.42 21.79 6 345111 22970 90260360
Skin haemorrhage 65.37 21.79 4 345113 21376 90261954
Rib fracture 65.32 21.79 11 345106 26424 90256906
Urinary retention 65.20 21.79 31 345086 37713 90245617
Panic attack 65.09 21.79 11 345106 26354 90256976
Fracture 64.97 21.79 5 345112 22071 90261259
Abnormal behaviour 64.19 21.79 6 345111 22622 90260708
Limb injury 64.17 21.79 20 345097 31488 90251842
Rheumatoid nodule 64.07 21.79 3 345114 20163 90263167
Acne 63.88 21.79 15 345102 28492 90254838
No adverse event 63.80 21.79 100 345017 67882 90215448
Nightmare 63.71 21.79 5 345112 21720 90261610
Osteomyelitis 63.71 21.79 14 345103 27832 90255498
Eye irritation 63.31 21.79 25 345092 33953 90249377
Unresponsive to stimuli 63.30 21.79 33 345084 38088 90245242
Injection site haemorrhage 63.26 21.79 15 345102 28303 90255027
Nervous system disorder 63.24 21.79 5 345112 21588 90261742
Diabetic ketoacidosis 62.94 21.79 9 345108 24398 90258932
Dysstasia 62.86 21.79 10 345107 25042 90258288
Joint injury 62.58 21.79 23 345094 32641 90250689
Peritonitis 62.39 21.79 3 345114 19702 90263628
Amnesia 62.38 21.79 660 344457 107845 90175485
Clostridium difficile infection 62.25 21.79 30 345087 36215 90247115
Full blood count decreased 62.00 21.79 18 345099 29671 90253659
Exposure during pregnancy 61.69 21.79 1262 343855 237148 90046182
Ventricular tachycardia 61.68 21.79 10 345107 24698 90258632
Face oedema 61.55 21.79 8 345109 23310 90260020
Head injury 61.39 21.79 21 345096 31167 90252163
Throat tightness 61.34 21.79 18 345099 29466 90253864
Dementia 61.06 21.79 9 345108 23852 90259478
Myelodysplastic syndrome 60.77 21.79 5 345112 20898 90262432
Electrolyte imbalance 60.67 21.79 9 345108 23736 90259594
Neuralgia 60.65 21.79 22 345095 31478 90251852
Rash macular 60.28 21.79 20 345097 30260 90253070
General symptom 60.09 21.79 156 344961 14512 90268818
Multiple sclerosis 59.77 21.79 16 345101 27824 90255506
Respiratory arrest 59.66 21.79 26 345091 33285 90250045
Pyelonephritis 59.55 21.79 6 345111 21310 90262020
Visual acuity reduced 59.52 21.79 9 345108 23401 90259929
Vasculitis 59.39 21.79 8 345109 22685 90260645
Status epilepticus 59.35 21.79 3 345114 18871 90264459
Urosepsis 59.26 21.79 6 345111 21226 90262104
Eye swelling 59.23 21.79 19 345098 29367 90253963
Withdrawal syndrome 58.80 21.79 8 345109 22516 90260814
Diabetes mellitus inadequate control 58.66 21.79 3 345114 18681 90264649
Feeling cold 58.56 21.79 16 345101 27449 90255881
Cardiomyopathy 58.29 21.79 5 345112 20201 90263129
Caesarean section 58.27 21.79 3 345114 18574 90264756
Neutrophil count increased 58.18 21.79 4 345113 19386 90263944
Lung neoplasm malignant 58.03 21.79 11 345106 24262 90259068
Polyneuropathy 58.01 21.79 4 345113 19337 90263993
Therapeutic response shortened 57.70 21.79 9 345108 22870 90260460
Injection site rash 57.69 21.79 11 345106 24162 90259168
Condition aggravated 57.62 21.79 2796 342321 592749 89690581
Injection site mass 57.31 21.79 8 345109 22082 90261248
Gastric disorder 56.78 21.79 28 345089 33356 90249974
Respiratory tract infection 56.30 21.79 86 345031 58992 90224338
Disease recurrence 56.28 21.79 37 345080 37616 90245714
Product substitution issue 56.19 21.79 3 345114 18005 90265325
Drug dependence 55.60 21.79 21 345096 29306 90254024
Pulmonary mass 55.56 21.79 20 345097 28752 90254578
Kidney infection 55.44 21.79 15 345102 25901 90257429
Ischaemic stroke 55.27 21.79 9 345108 22157 90261173
Bacterial infection 55.25 21.79 11 345106 23433 90259897
Malnutrition 55.19 21.79 4 345113 18554 90264776
Eye pruritus 54.67 21.79 21 345096 29006 90254324
Metastases to central nervous system 54.50 21.79 3 345114 17539 90265791
Injection site warmth 54.40 21.79 3 345114 17512 90265818
Haemorrhoids 54.29 21.79 17 345100 26685 90256645
Skin laceration 53.97 21.79 16 345101 26019 90257311
Heart rate irregular 53.93 21.79 13 345104 24255 90259075
Musculoskeletal disorder 53.92 21.79 9 345108 21760 90261570
Ulcer 53.81 21.79 29 345088 32853 90250477
Procedural pain 53.75 21.79 30 345087 33330 90250000
Bronchiectasis 53.64 21.79 10 345107 22320 90261010
Eye injury 53.41 21.79 125 344992 10895 90272435
Blood glucose decreased 53.15 21.79 12 345105 23417 90259913
Subarachnoid haemorrhage 52.84 21.79 4 345113 17900 90265430
Rash vesicular 52.77 21.79 171 344946 18026 90265304
Hypoacusis 52.70 21.79 20 345097 27830 90255500
Chronic obstructive pulmonary disease 52.46 21.79 128 344989 73701 90209629
Intervertebral disc protrusion 52.36 21.79 19 345098 27177 90256153
Abdominal pain upper 52.27 21.79 1647 343470 331027 89952303
Motor dysfunction 52.22 21.79 6 345111 19224 90264106
Drug withdrawal syndrome 52.11 21.79 22 345095 28701 90254629
Body temperature increased 52.01 21.79 56 345061 44654 90238676
Lacrimation increased 51.94 21.79 19 345098 27043 90256287
Pustular psoriasis 51.69 21.79 172 344945 18384 90264946
Mental impairment 51.51 21.79 3 345114 16717 90266613
Dizziness 51.29 21.79 1783 343334 587501 89695829
Cytopenia 51.21 21.79 4 345113 17445 90265885
Crying 50.95 21.79 17 345100 25628 90257702
Poor venous access 50.83 21.79 7 345110 19520 90263810
Complication associated with device 50.56 21.79 7 345110 19442 90263888
C-reactive protein increased 50.54 21.79 971 344146 180418 90102912
Injection site urticaria 50.50 21.79 5 345112 18006 90265324
Blood potassium increased 50.47 21.79 9 345108 20740 90262590
Coordination abnormal 50.37 21.79 10 345107 21346 90261984
Bronchospasm 50.33 21.79 9 345108 20700 90262630
Spondylitis 50.29 21.79 143 344974 14035 90269295
Faeces discoloured 50.25 21.79 10 345107 21310 90262020
Paraesthesia oral 50.25 21.79 29 345088 31630 90251700
Tachypnoea 50.22 21.79 10 345107 21299 90262031
Oral candidiasis 50.13 21.79 37 345080 35418 90247912
Malaise 50.09 21.79 1777 343340 584209 89699121
Hiatus hernia 50.05 21.79 17 345100 25344 90257986
Small intestinal obstruction 49.97 21.79 10 345107 21224 90262106
Product administration error 49.96 21.79 19 345098 26404 90256926
Muscle twitching 49.94 21.79 15 345102 24187 90259143
Intestinal obstruction 49.65 21.79 41 345076 37090 90246240
Skin necrosis 49.40 21.79 4 345113 16937 90266393
Generalised oedema 49.19 21.79 7 345110 19046 90264284
Dermatitis 49.18 21.79 12 345105 22208 90261122
Blood test abnormal 49.03 21.79 10 345107 20942 90262388
Foot fracture 48.88 21.79 20 345097 26586 90256744
Metastases to lung 48.87 21.79 3 345114 15988 90267342
Device difficult to use 48.79 21.79 5 345112 17520 90265810
Feeding disorder 48.74 21.79 5 345112 17507 90265823
Bone disorder 48.31 21.79 14 345103 23106 90260224
Brain oedema 48.29 21.79 5 345112 17380 90265950
Cyanosis 48.29 21.79 8 345109 19447 90263883
Iron deficiency anaemia 48.22 21.79 15 345102 23647 90259683
Sensory loss 48.20 21.79 6 345111 18069 90265261
Bone density decreased 48.15 21.79 5 345112 17340 90265990
Eye disorder 48.08 21.79 22 345095 27368 90255962
Spinal pain 48.06 21.79 3 345114 15764 90267566
Poor quality sleep 47.96 21.79 17 345100 24676 90258654
Oesophagitis 47.81 21.79 5 345112 17244 90266086
Progressive multifocal leukoencephalopathy 47.65 21.79 3 345114 15652 90267678
Heavy menstrual bleeding 47.62 21.79 10 345107 20520 90262810
Conjunctivitis 47.58 21.79 21 345096 26685 90256645
Coeliac disease 47.58 21.79 312 344805 44298 90239032
Flank pain 47.50 21.79 8 345109 19214 90264116
Photosensitivity reaction 47.27 21.79 6 345111 17801 90265529
Tooth disorder 47.22 21.79 30 345087 31060 90252270
Blood sodium decreased 47.20 21.79 23 345094 27590 90255740
Ankle fracture 47.09 21.79 10 345107 20360 90262970
Device malfunction 47.08 21.79 11 345106 20966 90262364
Hemiplegia 46.61 21.79 4 345113 16156 90267174
Glaucoma 46.35 21.79 11 345106 20744 90262586
Cardiac murmur 46.24 21.79 7 345110 18187 90265143
Spinal compression fracture 45.93 21.79 3 345114 15175 90268155
Toxic epidermal necrolysis 45.92 21.79 34 345083 32494 90250836
Treatment noncompliance 45.82 21.79 79 345038 51648 90231682
Uveitis 45.70 21.79 4 345113 15899 90267431
Rales 45.42 21.79 4 345113 15823 90267507
Ileus 45.34 21.79 5 345112 16541 90266789
Mydriasis 45.33 21.79 3 345114 15009 90268321
Petechiae 45.12 21.79 4 345113 15737 90267593
Hypokinesia 44.96 21.79 4 345113 15693 90267637
Infusion site reaction 44.86 21.79 167 344950 18872 90264458
Blood pressure abnormal 44.69 21.79 10 345107 19635 90263695
Mitral valve incompetence 44.63 21.79 15 345102 22509 90260821
Hypoaesthesia oral 44.62 21.79 4 345113 15596 90267734
Skin burning sensation 44.58 21.79 10 345107 19601 90263729
Pharyngitis 44.57 21.79 14 345103 21933 90261397
Hypothermia 44.53 21.79 4 345113 15571 90267759
Nail operation 44.37 21.79 45 345072 1861 90281469
Sinus bradycardia 44.30 21.79 6 345111 16946 90266384
Abscess 44.24 21.79 9 345108 18882 90264448
Transfusion 43.83 21.79 7 345110 17481 90265849
Respiratory tract congestion 43.66 21.79 25 345092 27385 90255945
Accidental overdose 43.33 21.79 27 345090 28246 90255084
Subdural haematoma 43.25 21.79 6 345111 16639 90266691
Right ventricular failure 43.24 21.79 10 345107 19195 90264135
Spinal fracture 43.03 21.79 15 345102 22001 90261329
Breast cancer metastatic 42.96 21.79 4 345113 15128 90268202
Deafness 42.88 21.79 16 345101 22498 90260832
Product storage error 42.77 21.79 12 345105 20229 90263101
Emotional distress 42.55 21.79 46 345071 36616 90246714
Sleep apnoea syndrome 42.52 21.79 35 345082 31712 90251618
Gingival bleeding 42.15 21.79 4 345113 14899 90268431
Parkinsonism 41.92 21.79 3 345114 14062 90269268
COVID-19 pneumonia 41.86 21.79 9 345108 18168 90265162
Anuria 41.85 21.79 4 345113 14814 90268516
Purpura 41.70 21.79 4 345113 14774 90268556
Impaired work ability 41.69 21.79 11 345106 19315 90264015
Blood albumin decreased 41.50 21.79 7 345110 16796 90266534
Spinal stenosis 41.43 21.79 8 345109 17416 90265914
Sensory disturbance 41.38 21.79 5 345112 15408 90267922
Pelvic pain 41.19 21.79 5 345112 15352 90267978
Retching 41.15 21.79 11 345106 19148 90264182
Ovarian cyst 41.08 21.79 8 345109 17310 90266020
Escherichia urinary tract infection 41.02 21.79 3 345114 13812 90269518
Tenosynovitis 40.96 21.79 4 345113 14563 90268767
Red blood cell sedimentation rate increased 40.92 21.79 488 344629 82107 90201223
Joint stiffness 40.85 21.79 466 344651 77576 90205754
Ear infection 40.84 21.79 426 344691 69349 90213981
Skin infection 40.83 21.79 9 345108 17855 90265475
Swollen joint count 40.69 21.79 97 345020 8556 90274774
Musculoskeletal chest pain 40.27 21.79 20 345097 23730 90259600
Oral pain 40.21 21.79 39 345078 32644 90250686
Bronchitis 40.19 21.79 380 344737 152547 90130783
Hypocalcaemia 40.06 21.79 62 345055 42306 90241024
Muscle rigidity 40.05 21.79 4 345113 14305 90269025
Mass 39.58 21.79 6 345111 15571 90267759
Osteopenia 39.56 21.79 19 345098 22983 90260347
Glycosylated haemoglobin increased 39.52 21.79 6 345111 15556 90267774
Pneumothorax 39.33 21.79 12 345105 19155 90264175
Skin fissures 39.28 21.79 15 345102 20794 90262536
Hepatomegaly 39.27 21.79 3 345114 13323 90270007
Ventricular fibrillation 39.11 21.79 4 345113 14040 90269290
Pain of skin 39.06 21.79 7 345110 16075 90267255
Dermatitis allergic 39.06 21.79 9 345108 17318 90266012
Ventricular extrasystoles 38.99 21.79 3 345114 13247 90270083
Blood urine present 38.90 21.79 9 345108 17269 90266061
Thyroid disorder 38.60 21.79 10 345107 17775 90265555
Intestinal perforation 38.54 21.79 4 345113 13877 90269453
Mood altered 38.46 21.79 9 345108 17135 90266195
Renal tubular necrosis 38.40 21.79 5 345112 14550 90268780
Carpal tunnel syndrome 37.86 21.79 22 345095 23906 90259424
Atelectasis 37.84 21.79 23 345094 24386 90258944
Tendonitis 37.77 21.79 17 345100 21355 90261975
Extrapyramidal disorder 37.70 21.79 8 345109 16295 90267035
Chromaturia 37.63 21.79 13 345104 19174 90264156
Wrist fracture 37.52 21.79 7 345110 15617 90267713
Drug tolerance 37.20 21.79 151 344966 17765 90265565
Hypophosphataemia 37.11 21.79 6 345111 14848 90268482
Impaired quality of life 37.02 21.79 21 345096 23123 90260207
Intervertebral disc degeneration 36.95 21.79 10 345107 17264 90266066
Fear 36.75 21.79 9 345108 16613 90266717
Product dose omission in error 36.72 21.79 16 345101 20487 90262843
Device breakage 36.63 21.79 5 345112 14039 90269291
Musculoskeletal discomfort 36.62 21.79 17 345100 20974 90262356
Hallucination, auditory 36.61 21.79 8 345109 15967 90267363
Troponin increased 36.43 21.79 4 345113 13277 90270053
Lung infiltration 36.37 21.79 7 345110 15275 90268055
Arterial occlusive disease 36.12 21.79 3 345114 12443 90270887
Nervousness 36.02 21.79 46 345071 34010 90249320
Hydronephrosis 35.96 21.79 3 345114 12399 90270931
Ataxia 35.77 21.79 12 345105 18030 90265300
Mood swings 35.76 21.79 17 345100 20685 90262645
Eosinophil count increased 35.73 21.79 4 345113 13077 90270253
Blood iron decreased 35.51 21.79 12 345105 17947 90265383
Post procedural complication 35.49 21.79 14 345103 19028 90264302
Acute generalised exanthematous pustulosis 35.46 21.79 5 345112 13698 90269632
Hypersomnia 35.22 21.79 19 345098 21512 90261818
Tricuspid valve incompetence 35.20 21.79 10 345107 16721 90266609
Dermatitis atopic 35.17 21.79 23 345094 23449 90259881
Facial paralysis 35.15 21.79 8 345109 15526 90267804
Joint destruction 35.10 21.79 121 344996 13166 90270164
Lymphoma 35.07 21.79 5 345112 13586 90269744
Ageusia 34.97 21.79 9 345108 16067 90267263
Cyst 34.65 21.79 10 345107 16551 90266779
Postoperative wound infection 34.51 21.79 5 345112 13421 90269909
Toothache 34.38 21.79 21 345096 22209 90261121
Cholecystitis 34.37 21.79 11 345106 17029 90266301
Needle issue 33.99 21.79 6 345111 13928 90269402
Supraventricular tachycardia 33.93 21.79 10 345107 16326 90267004
Head discomfort 33.92 21.79 10 345107 16323 90267007
Anxiety 33.84 21.79 909 344208 308863 89974467
Gout 33.80 21.79 11 345106 16848 90266482
Hyperlipidaemia 33.60 21.79 23 345094 22893 90260437
Ankylosing spondylitis 33.50 21.79 5 345112 13128 90270202
Hypovolaemia 33.46 21.79 4 345113 12427 90270903
Sinus congestion 33.42 21.79 33 345084 27391 90255939
Sputum discoloured 33.34 21.79 18 345099 20373 90262957
Central nervous system lesion 33.27 21.79 3 345114 11643 90271687
Hepatic enzyme 33.19 21.79 67 345050 5277 90278053
Medication error 33.10 21.79 479 344638 84173 90199157
Pseudomonas infection 32.96 21.79 8 345109 14857 90268473
Skin irritation 32.87 21.79 6 345111 13597 90269733
Hernia 32.87 21.79 7 345110 14224 90269106
Breath sounds abnormal 32.73 21.79 9 345108 15377 90267953
Vitamin D deficiency 32.57 21.79 13 345104 17543 90265787
Upper limb fracture 32.53 21.79 21 345096 21557 90261773
Cardiovascular disorder 32.50 21.79 6 345111 13486 90269844
Psychomotor hyperactivity 32.41 21.79 5 345112 12808 90270522
Anal incontinence 31.82 21.79 11 345106 16219 90267111
Peripheral coldness 31.75 21.79 7 345110 13885 90269445
Urine output decreased 31.69 21.79 5 345112 12598 90270732
Akathisia 31.54 21.79 3 345114 11156 90272174
Synovial cyst 31.10 21.79 4 345113 11748 90271582
Restless legs syndrome 31.06 21.79 24 345093 22446 90260884
Eye infection 30.97 21.79 8 345109 14246 90269084
Colon cancer 30.78 21.79 3 345114 10941 90272389
Sudden death 30.66 21.79 3 345114 10906 90272424
Hepatitis acute 30.58 21.79 3 345114 10884 90272446
Eructation 30.56 21.79 3 345114 10879 90272451
Nasal polyps 30.56 21.79 3 345114 10877 90272453
Skin cancer 30.52 21.79 7 345110 13512 90269818
Tongue disorder 30.49 21.79 3 345114 10857 90272473
Grip strength 30.42 21.79 89 345028 8876 90274454
Cold sweat 30.40 21.79 8 345109 14073 90269257
Red cell distribution width increased 30.34 21.79 5 345112 12202 90271128
Rhinitis allergic 30.22 21.79 13 345104 16772 90266558
Blood magnesium decreased 30.15 21.79 11 345106 15682 90267648
Hypocholesterolaemia 30.01 21.79 72 345045 6377 90276953
Tooth infection 29.90 21.79 20 345097 20150 90263180
Immunosuppression 29.90 21.79 5 345112 12072 90271258
Sarcoidosis 29.83 21.79 3 345114 10670 90272660
Choking 29.75 21.79 5 345112 12028 90271302
Myositis 29.64 21.79 175 344942 23953 90259377
Dialysis 29.63 21.79 4 345113 11325 90272005
Malignant melanoma 29.43 21.79 6 345111 12570 90270760
Pharyngeal oedema 29.40 21.79 8 345109 13763 90269567
Cardiac failure acute 29.40 21.79 5 345112 11924 90271406
Micturition urgency 29.30 21.79 4 345113 11229 90272101
Quality of life decreased 29.26 21.79 5 345112 11884 90271446
Anger 29.24 21.79 8 345109 13712 90269618
Abdominal distension 29.22 21.79 337 344780 130264 90153066
Cardiomegaly 29.10 21.79 18 345099 18907 90264423
Tooth abscess 29.09 21.79 13 345104 16400 90266930
Cushingoid 28.85 21.79 3 345114 10392 90272938
Increased appetite 28.84 21.79 5 345112 11760 90271570
Concussion 28.81 21.79 4 345113 11087 90272243
Arthralgia 28.74 21.79 3385 341732 775137 89508193
Pelvic fracture 28.68 21.79 11 345106 15208 90268122
Product dispensing error 28.42 21.79 6 345111 12267 90271063
Nocturia 28.36 21.79 3 345114 10252 90273078
Drug dose omission by device 28.27 21.79 3 345114 10228 90273102
Appendicitis 28.27 21.79 3 345114 10228 90273102
Tardive dyskinesia 28.26 21.79 4 345113 10926 90272404
Drug ineffective 28.16 21.79 4740 340377 1379558 88903772
Bedridden 28.01 21.79 6 345111 12142 90271188
Acidosis 27.95 21.79 7 345110 12729 90270601
Sinus disorder 27.52 21.79 56 345061 34391 90248939
Diarrhoea haemorrhagic 27.34 21.79 4 345113 10659 90272671
Thirst 27.21 21.79 14 345103 16281 90267049
Gestational diabetes 27.06 21.79 4 345113 10578 90272752
Scratch 26.99 21.79 3 345114 9863 90273467
Incorrect route of product administration 26.81 21.79 303 344814 50323 90233007
Product complaint 26.73 21.79 9 345108 13491 90269839
Oral discomfort 26.72 21.79 4 345113 10479 90272851
Product use in unapproved indication 26.68 21.79 1550 343567 334686 89948644
Aphonia 26.60 21.79 7 345110 12312 90271018
Gastrointestinal infection 26.23 21.79 5 345112 10985 90272345
Pharyngitis streptococcal 26.10 21.79 8 345109 12734 90270596
Electrocardiogram abnormal 26.09 21.79 4 345113 10294 90273036
Scar 26.05 21.79 13 345104 15382 90267948
Concomitant disease aggravated 25.93 21.79 6 345111 11512 90271818
Multiple fractures 25.93 21.79 3 345114 9559 90273771
Therapeutic response unexpected 25.90 21.79 27 345090 21853 90261477
Spinal fusion surgery 25.88 21.79 104 345013 12179 90271151
Femoral neck fracture 25.86 21.79 4 345113 10229 90273101
Underdose 25.82 21.79 317 344800 53700 90229630
Paralysis 25.80 21.79 6 345111 11472 90271858
Arteriosclerosis 25.77 21.79 5 345112 10848 90272482
Embolism 25.64 21.79 3 345114 9478 90273852
Cardiotoxicity 25.50 21.79 6 345111 11383 90271947
Congenital anomaly 25.49 21.79 67 345050 6280 90277050
Dyslipidaemia 25.43 21.79 4 345113 10103 90273227
Hypernatraemia 25.31 21.79 3 345114 9384 90273946
Enterococcal infection 25.04 21.79 4 345113 9987 90273343
Device leakage 25.04 21.79 4 345113 9987 90273343
Skin abrasion 25.00 21.79 6 345111 11229 90272101
Blood pressure systolic decreased 24.91 21.79 3 345114 9267 90274063
Muscle tightness 24.85 21.79 10 345107 13429 90269901
Adverse reaction 24.85 21.79 196 344921 29516 90253814
Incontinence 24.84 21.79 10 345107 13425 90269905
Nephropathy 24.78 21.79 3 345114 9232 90274098
Ecchymosis 24.78 21.79 8 345109 12315 90271015
Tenderness 24.75 21.79 40 345077 26828 90256502
Intentional dose omission 24.57 21.79 19 345098 17764 90265566
Injection site induration 24.48 21.79 5 345112 10463 90272867
Post procedural infection 24.47 21.79 6 345111 11068 90272262
Pleuritic pain 24.46 21.79 5 345112 10456 90272874
Sneezing 24.34 21.79 48 345069 29821 90253509
Middle insomnia 24.31 21.79 17 345100 16734 90266596
Chronic sinusitis 24.30 21.79 33 345084 23769 90259561
Lymphoedema 24.21 21.79 11 345106 13742 90269588
Skin reaction 24.18 21.79 21 345096 18532 90264798
Pulmonary congestion 24.13 21.79 23 345094 19410 90263920
Eyelid oedema 24.07 21.79 7 345110 11527 90271803
Pulmonary toxicity 24.06 21.79 7 345110 11524 90271806
Injection site extravasation 24.03 21.79 3 345114 9016 90274314
Gallbladder disorder 23.94 21.79 24 345093 19779 90263551
Tooth fracture 23.92 21.79 9 345108 12591 90270739
Uterine leiomyoma 23.79 21.79 6 345111 10858 90272472
Mania 23.79 21.79 12 345105 14112 90269218
Fatigue 23.73 21.79 4856 340261 1149167 89134163
Acute coronary syndrome 23.62 21.79 6 345111 10807 90272523
Bladder disorder 23.49 21.79 6 345111 10766 90272564
Spinal osteoarthritis 23.38 21.79 23 345094 19125 90264205
Renal cyst 23.36 21.79 10 345107 12940 90270390
Atrioventricular block 23.32 21.79 3 345114 8812 90274518
Rotator cuff syndrome 23.31 21.79 16 345101 15903 90267427
Limb discomfort 23.28 21.79 71 345046 37989 90245341
Colitis ischaemic 23.14 21.79 9 345108 12337 90270993
Feeling jittery 23.11 21.79 15 345102 15356 90267974
Gastrointestinal pain 23.02 21.79 7 345110 11199 90272131
Hereditary angioedema 22.91 21.79 4 345113 9361 90273969
Abdominal tenderness 22.77 21.79 4 345113 9320 90274010
Pharyngeal swelling 22.75 21.79 5 345112 9939 90273391
Initial insomnia 22.73 21.79 4 345113 9306 90274024
Blood triglycerides increased 22.72 21.79 12 345105 13749 90269581
Nerve injury 22.70 21.79 7 345110 11099 90272231
Poisoning 22.68 21.79 15 345102 15202 90268128
Device occlusion 22.63 21.79 4 345113 9278 90274052
Joint effusion 22.58 21.79 25 345092 19685 90263645
Ligament sprain 22.29 21.79 14 345103 14585 90268745
Fear of injection 22.29 21.79 3 345114 8512 90274818
Mouth haemorrhage 22.24 21.79 3 345114 8498 90274832
Pain in extremity 21.82 21.79 1450 343667 449079 89834251

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sinusitis 65.54 13.48 79 13839 47213 42560204
Penile abscess 63.90 13.48 14 13904 151 42607266
Sudden infant death syndrome 49.82 13.48 13 13905 307 42607110
Dyspnoea 46.40 13.48 274 13644 442347 42165070
Multiple allergies 45.83 13.48 23 13895 3705 42603712
Chronic obstructive pulmonary disease 45.21 13.48 77 13841 63037 42544380
Kidney duplex 42.06 13.48 12 13906 399 42607018
Cough 37.05 13.48 135 13783 177968 42429449
Productive cough 37.04 13.48 63 13855 51504 42555913
Cardiac septal defect 32.06 13.48 12 13906 948 42606469
Off label use 30.47 13.48 107 13811 638228 41969189
Bronchitis 30.44 13.48 55 13863 47146 42560271
Asthma-chronic obstructive pulmonary disease overlap syndrome 29.64 13.48 13 13905 1546 42605871
Pneumonia 29.63 13.48 237 13681 421912 42185505
Acute kidney injury 29.11 13.48 47 13871 367290 42240127
Nasal congestion 28.05 13.48 41 13877 29460 42577957
Symmetrical drug-related intertriginous and flexural exanthema 25.92 13.48 10 13908 858 42606559
Mycobacterial infection 23.01 13.48 13 13905 2655 42604762
Priapism 22.84 13.48 18 13900 6389 42601028
SARS-CoV-2 test negative 21.96 13.48 11 13907 1764 42605653
Fatigue 21.60 13.48 227 13691 435414 42172003
Nasopharyngitis 21.23 13.48 68 13850 83928 42523489
Upper respiratory tract infection 19.76 13.48 43 13875 42130 42565287
Anal inflammation 19.60 13.48 11 13907 2218 42605199
Hypoxic-ischaemic encephalopathy 19.38 13.48 15 13903 5187 42602230
Substance abuser 19.22 13.48 6 13912 273 42607144
Product dose omission issue 18.32 13.48 99 13819 154266 42453151
General physical health deterioration 17.79 13.48 14 13904 151232 42456185
Sinus congestion 17.47 13.48 16 13902 6964 42600453
Seasonal allergy 15.52 13.48 16 13902 8039 42599378
Bradycardia 14.34 13.48 5 13913 85479 42521938
Rhabdomyolysis 14.09 13.48 4 13914 78015 42529402
Congenital central nervous system anomaly 13.79 13.48 6 13912 699 42606718
Thrombocytopenia 13.53 13.48 26 13892 190253 42417164

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2997.42 20.07 3154 271727 211416 110103002
Systemic lupus erythematosus 2863.51 20.07 3339 271542 250999 110063419
Pericarditis 2788.37 20.07 3066 271815 216048 110098370
Glossodynia 2734.65 20.07 3054 271827 218950 110095468
Hand deformity 2705.36 20.07 3014 271867 215492 110098926
Wound 2549.03 20.07 3024 271857 231413 110083005
Anti-cyclic citrullinated peptide antibody positive 2379.67 20.07 2584 272297 179400 110135018
Synovitis 2302.77 20.07 3109 271772 270983 110043435
Duodenal ulcer perforation 2263.89 20.07 2489 272392 175211 110139207
Helicobacter infection 2204.38 20.07 2482 272399 179395 110135023
Folliculitis 1788.43 20.07 2143 272738 165510 110148908
Swelling 1780.99 20.07 3154 271727 347887 109966531
Arthropathy 1772.34 20.07 2819 272062 284703 110029715
Discomfort 1694.19 20.07 2364 272517 212343 110102075
Irritable bowel syndrome 1682.95 20.07 2057 272824 162158 110152260
Alopecia 1622.93 20.07 3097 271784 361656 109952762
Abdominal discomfort 1600.80 20.07 3219 271662 390639 109923779
Muscle injury 1574.40 20.07 1844 273037 138963 110175455
Hepatic enzyme increased 1573.15 20.07 2841 272040 318051 109996367
Rheumatic fever 1487.81 20.07 1675 273206 120904 110193514
Blister 1431.65 20.07 2252 272629 225124 110089294
Rheumatoid factor positive 1425.29 20.07 1696 273185 129944 110184474
Impaired healing 1406.24 20.07 2067 272814 194650 110119768
Infusion related reaction 1369.17 20.07 2962 271919 378200 109936218
Sleep disorder due to general medical condition, insomnia type 1297.97 20.07 1453 273428 104190 110210228
Type 2 diabetes mellitus 1285.01 20.07 1875 273006 175357 110139061
Acute kidney injury 1229.91 20.07 92 274789 635338 109679080
Contraindicated product administered 1229.81 20.07 2209 272672 246058 110068360
Maternal exposure during pregnancy 1222.10 20.07 2236 272645 252647 110061771
Hypersensitivity 1209.89 20.07 2922 271959 401076 109913342
Joint swelling 1146.70 20.07 3031 271850 439814 109874604
Psoriatic arthropathy 1107.77 20.07 1853 273028 194908 110119510
Swollen joint count increased 1085.09 20.07 1184 273697 82477 110231941
Stomatitis 1050.47 20.07 2170 272711 268072 110046346
Ill-defined disorder 1047.40 20.07 1597 273284 155256 110159162
Therapeutic product effect decreased 1022.33 20.07 2023 272858 242293 110072125
Blood cholesterol increased 960.71 20.07 1680 273201 183105 110131313
Fibromyalgia 955.77 20.07 1605 273276 169304 110145114
Injury 941.58 20.07 1627 273254 175638 110138780
Drug interaction 940.78 20.07 82 274799 500101 109814317
Anaemia 913.44 20.07 136 274745 546950 109767468
Lower respiratory tract infection 894.34 20.07 1909 272972 241197 110073221
Drug intolerance 878.12 20.07 2606 272275 403906 109910512
Facet joint syndrome 853.50 20.07 1126 273755 95702 110218716
Liver injury 852.21 20.07 1421 273460 148992 110165426
Lip dry 850.18 20.07 1143 273738 98940 110215478
Joint range of motion decreased 781.57 20.07 1218 273663 120614 110193804
Hypotension 766.22 20.07 181 274700 523668 109790750
Peripheral venous disease 730.21 20.07 971 273910 83146 110231272
Neutropenia 681.35 20.07 70 274811 374550 109939868
Mobility decreased 664.67 20.07 1675 273206 235747 110078671
Gastrointestinal disorder 657.64 20.07 1688 273193 240264 110074154
Treatment failure 607.16 20.07 1787 273094 275447 110038971
Death 606.05 20.07 509 274372 698360 109616058
Sinusitis 605.16 20.07 1865 273016 294823 110019595
C-reactive protein abnormal 598.36 20.07 1120 273761 128575 110185843
Toxicity to various agents 590.58 20.07 228 274653 480327 109834091
Bursitis 587.04 20.07 1112 273769 128806 110185612
Febrile neutropenia 576.45 20.07 59 274822 316708 109997710
Deep vein thrombosis postoperative 555.85 20.07 711 274170 58580 110255838
Night sweats 550.82 20.07 1102 273779 132881 110181537
Breast cancer stage III 545.35 20.07 818 274063 78299 110236119
Obesity 538.05 20.07 991 273890 112360 110202058
Wound infection 524.39 20.07 895 273986 95570 110218848
Sepsis 524.25 20.07 91 274790 327255 109987163
Musculoskeletal stiffness 503.29 20.07 1685 273196 278137 110036281
Grip strength decreased 493.87 20.07 787 274094 79387 110235031
Sleep disorder 487.91 20.07 1335 273546 197309 110117109
Osteoarthritis 487.64 20.07 1266 273615 181357 110133061
Product use issue 485.63 20.07 1790 273091 309905 110004513
Sciatica 473.15 20.07 835 274046 91564 110222854
Autoimmune disorder 459.81 20.07 683 274198 64800 110249618
Weight increased 455.51 20.07 2157 272724 417487 109896931
Nasopharyngitis 455.27 20.07 2064 272817 392297 109922121
Dry mouth 454.95 20.07 1307 273574 198641 110115777
Somnolence 454.30 20.07 93 274788 297356 110017062
Road traffic accident 445.75 20.07 887 273994 106511 110207907
Blepharospasm 442.23 20.07 611 274270 54240 110260178
Disease progression 439.93 20.07 47 274834 243987 110070431
Contusion 439.88 20.07 1428 273453 231933 110082485
Pancytopenia 433.03 20.07 21 274860 209592 110104826
Fall 431.95 20.07 519 274362 602963 109711455
Lower limb fracture 418.63 20.07 706 274175 74642 110239776
Constipation 416.33 20.07 184 274697 357602 109956816
Thrombocytopenia 416.20 20.07 173 274708 348712 109965706
Hypercholesterolaemia 408.36 20.07 776 274105 90061 110224357
Platelet count decreased 406.28 20.07 48 274833 230395 110084023
Onychomadesis 402.13 20.07 531 274350 45132 110269286
Live birth 401.99 20.07 663 274218 68821 110245597
Hip arthroplasty 401.74 20.07 589 274292 55224 110259194
Hypoaesthesia 401.66 20.07 1696 273185 312527 110001891
Cough 401.22 20.07 335 274546 461306 109853112
Wheezing 398.44 20.07 1467 273414 253763 110060655
Infection 397.47 20.07 1868 273013 360332 109954086
General physical health deterioration 395.71 20.07 2093 272788 423202 109891216
Hyponatraemia 394.68 20.07 41 274840 217612 110096806
Gait inability 390.58 20.07 971 273910 135405 110179013
Dehydration 390.09 20.07 106 274775 279405 110035013
Erythema 378.69 20.07 126 274755 291321 110023097
Inflammation 375.44 20.07 1195 273686 192043 110122375
Adjustment disorder with depressed mood 370.64 20.07 500 274381 43383 110271035
Adverse event 368.36 20.07 827 274054 107982 110206436
Renal impairment 367.58 20.07 26 274855 188419 110125999
Urinary tract infection 366.85 20.07 176 274705 326106 109988312
Peripheral swelling 366.02 20.07 1974 272907 402060 109912358
Renal failure 360.45 20.07 64 274817 226510 110087908
Dislocation of vertebra 356.91 20.07 490 274391 43231 110271187
Lung disorder 354.86 20.07 1119 273762 178928 110135490
Cardiac failure 351.67 20.07 31 274850 187595 110126823
Nail disorder 342.14 20.07 558 274323 57377 110257041
Haemoglobin decreased 340.22 20.07 98 274783 248629 110065789
Back pain 327.49 20.07 265 274616 370731 109943687
Intentional product use issue 324.40 20.07 1348 273533 246558 110067860
Nausea 322.90 20.07 1781 273100 1233909 109080509
Blood creatinine increased 322.60 20.07 38 274843 182851 110131567
X-ray abnormal 321.44 20.07 434 274447 37683 110276735
Multiple organ dysfunction syndrome 320.55 20.07 13 274868 151697 110162721
Bradycardia 316.69 20.07 17 274864 155500 110158918
Seizure 314.06 20.07 81 274800 221104 110093314
Malignant neoplasm progression 313.62 20.07 34 274847 174533 110139885
Rash 312.49 20.07 3264 271617 817700 109496718
Knee arthroplasty 310.81 20.07 570 274311 64378 110250040
Alanine aminotransferase increased 310.14 20.07 44 274837 183729 110130689
Blood pressure increased 308.24 20.07 128 274753 258245 110056173
Retinitis 308.20 20.07 391 274490 31936 110282482
White blood cell count decreased 307.14 20.07 94 274787 229296 110085122
Onychomycosis 305.76 20.07 426 274455 38105 110276313
Prescribed overdose 304.66 20.07 673 274208 86908 110227510
Atrial fibrillation 293.55 20.07 102 274779 229540 110084878
Taste disorder 290.65 20.07 556 274325 64831 110249587
Urticaria 290.03 20.07 1560 273321 317297 109997121
C-reactive protein 287.81 20.07 366 274515 29965 110284453
Product dose omission issue 287.53 20.07 227 274654 321555 109992863
Syncope 285.96 20.07 75 274806 202461 110111957
Hyperkalaemia 282.39 20.07 13 274868 135783 110178635
Confusional state 278.95 20.07 2057 272824 466623 109847795
Musculoskeletal pain 278.79 20.07 1044 273837 181979 110132439
Lupus vulgaris 276.94 20.07 380 274501 33503 110280915
Aspartate aminotransferase increased 270.56 20.07 38 274843 159898 110154520
Pain 267.06 20.07 3579 271302 951376 109363042
Respiratory failure 262.83 20.07 103 274778 215229 110099189
Rhabdomyolysis 262.45 20.07 8 274873 120393 110194025
Myocardial infarction 262.07 20.07 76 274805 192007 110122411
Drug abuse 261.56 20.07 60 274821 177351 110137067
Off label use 258.39 20.07 2437 272444 1497748 108816670
Tremor 258.17 20.07 90 274791 202142 110112276
Neuropathy peripheral 257.68 20.07 64 274817 179213 110135205
Hyperhidrosis 252.08 20.07 76 274805 187222 110127196
Cardiac arrest 248.70 20.07 89 274792 196664 110117754
Anti-cyclic citrullinated peptide antibody 245.61 20.07 275 274606 19689 110294729
Completed suicide 242.89 20.07 151 274730 242230 110072188
Cerebrovascular accident 234.30 20.07 79 274802 181205 110133213
Exposure during pregnancy 233.68 20.07 929 273952 166495 110147923
Migraine 232.82 20.07 944 273937 170708 110143710
Hypoglycaemia 232.36 20.07 14 274867 116090 110198328
COVID-19 231.61 20.07 163 274718 244897 110069521
Pregnancy 231.60 20.07 438 274443 50629 110263789
Diarrhoea 228.53 20.07 1778 273103 1137727 109176691
Exostosis 228.35 20.07 410 274471 45546 110268872
Product quality issue 226.10 20.07 555 274326 76744 110237674
Septic shock 224.91 20.07 57 274824 157471 110156947
Gastrointestinal haemorrhage 224.85 20.07 66 274815 165452 110148966
Pulmonary embolism 224.21 20.07 127 274754 214347 110100071
Myalgia 222.18 20.07 139 274742 222242 110092176
Inappropriate schedule of product administration 219.54 20.07 116 274765 203521 110110897
Injection site pain 218.95 20.07 84 274797 177838 110136580
Myelosuppression 218.51 20.07 3 274878 94337 110220081
Lupus-like syndrome 218.31 20.07 376 274505 40416 110274002
Neutrophil count decreased 216.08 20.07 24 274857 120917 110193501
Memory impairment 215.91 20.07 1016 273865 195928 110118490
Oedema 215.61 20.07 1063 273818 208913 110105505
Interstitial lung disease 211.72 20.07 44 274837 139290 110175128
Bone erosion 210.63 20.07 398 274483 45973 110268445
Oxygen saturation decreased 208.89 20.07 65 274816 156917 110157501
Rheumatoid arthritis 208.70 20.07 1367 273514 298246 110016172
Coma 206.58 20.07 25 274856 117844 110196574
Hypokalaemia 204.06 20.07 99 274782 182349 110132069
Blood glucose increased 203.06 20.07 41 274840 132455 110181963
Metabolic acidosis 202.76 20.07 11 274870 99733 110214685
Depressed level of consciousness 201.31 20.07 22 274859 112256 110202162
Chest discomfort 199.57 20.07 91 274790 173757 110140661
Lactic acidosis 199.32 20.07 7 274874 92804 110221614
Electrocardiogram QT prolonged 198.83 20.07 20 274861 108940 110205478
Laryngitis 196.35 20.07 367 274514 42044 110272374
Hepatic function abnormal 194.37 20.07 6 274875 89289 110225129
Intentional overdose 192.94 20.07 46 274835 132455 110181963
Liver disorder 191.85 20.07 781 274100 141462 110172956
Pulmonary fibrosis 190.74 20.07 623 274258 101419 110212999
Pleural effusion 190.42 20.07 102 274779 177607 110136811
Leukopenia 190.26 20.07 66 274815 148725 110165693
Mucosal inflammation 188.21 20.07 13 274868 96128 110218290
Herpes zoster 187.46 20.07 24 274857 108355 110206063
Influenza 185.73 20.07 94 274787 169007 110145411
Blood pressure decreased 184.09 20.07 32 274849 115059 110199359
Back injury 182.94 20.07 380 274501 47019 110267399
Chills 179.74 20.07 127 274754 190453 110123965
Ascites 174.77 20.07 15 274866 92793 110221625
Loss of consciousness 172.12 20.07 141 274740 196165 110118253
Heart rate increased 171.89 20.07 71 274810 143763 110170655
Prescribed underdose 170.88 20.07 449 274432 64725 110249693
Suicide attempt 169.26 20.07 27 274854 103367 110211051
Drug reaction with eosinophilia and systemic symptoms 167.03 20.07 9 274872 82086 110232332
Epistaxis 166.40 20.07 58 274823 130314 110184104
Feeling abnormal 160.67 20.07 128 274753 180583 110133835
Angioedema 160.62 20.07 26 274855 98474 110215944
Blood pressure systolic increased 160.22 20.07 12 274869 82979 110231439
Cytokine release syndrome 159.61 20.07 3 274878 70303 110244115
Blood bilirubin increased 158.83 20.07 7 274874 75965 110238453
Palpitations 158.34 20.07 100 274781 159112 110155306
Balance disorder 157.35 20.07 47 274834 116513 110197905
Dysphagia 156.19 20.07 94 274787 153506 110160912
Vertigo 155.79 20.07 17 274864 86853 110227565
Maternal exposure timing unspecified 152.97 20.07 223 274658 20790 110293628
Cellulitis 152.54 20.07 61 274820 125955 110188463
Porphyria acute 152.53 20.07 210 274671 18570 110295848
Epilepsy 151.15 20.07 570 274311 99639 110214779
Pneumonia 147.78 20.07 1430 273451 875284 109439134
Abdominal pain upper 144.71 20.07 1414 273467 347697 109966721
Product label confusion 144.26 20.07 226 274655 22451 110291967
Haemorrhage 144.06 20.07 43 274838 106649 110207769
Finger deformity 142.88 20.07 278 274603 32814 110281604
Rash maculo-papular 142.53 20.07 11 274870 74211 110240207
Foot deformity 141.66 20.07 348 274533 48132 110266286
Agitation 141.37 20.07 52 274829 112999 110201419
Hyperglycaemia 139.78 20.07 22 274859 85068 110229350
Vision blurred 139.77 20.07 73 274808 128949 110185469
Thrombosis 139.26 20.07 48 274833 108614 110205804
Heart rate decreased 139.15 20.07 20 274861 82736 110231682
Agranulocytosis 138.75 20.07 3 274878 61757 110252661
Oropharyngeal pain 138.65 20.07 82 274799 135194 110179224
Haematochezia 138.08 20.07 57 274824 115467 110198951
Encephalopathy 137.67 20.07 19 274862 81036 110233382
Blood creatine phosphokinase increased 137.09 20.07 12 274869 73065 110241353
Cardiac failure congestive 135.44 20.07 106 274775 150894 110163524
Dysarthria 135.39 20.07 23 274858 84098 110230320
Dyspnoea exertional 135.04 20.07 45 274836 104015 110210403
Hypoxia 134.88 20.07 77 274804 129438 110184980
Stress 134.21 20.07 47 274834 105301 110209117
Pulmonary oedema 133.33 20.07 42 274839 100617 110213801
Flushing 132.96 20.07 47 274834 104689 110209729
Adverse drug reaction 132.46 20.07 567 274314 104992 110209426
Cognitive disorder 132.18 20.07 28 274853 87483 110226935
Wrong technique in product usage process 131.83 20.07 28 274853 87320 110227098
Disorientation 131.51 20.07 12 274869 70659 110243759
Cardio-respiratory arrest 130.81 20.07 62 274819 115774 110198644
Hepatic failure 129.73 20.07 11 274870 68728 110245690
Breast cancer stage II 129.36 20.07 239 274642 27136 110287282
Hepatotoxicity 128.83 20.07 7 274874 63393 110251025
Skin exfoliation 128.45 20.07 30 274851 87621 110226797
Blood pressure fluctuation 128.36 20.07 17 274864 74807 110239611
Colitis 128.05 20.07 47 274834 102276 110212142
Lymphocyte count decreased 127.74 20.07 3 274878 57240 110257178
Incorrect dose administered 127.37 20.07 49 274832 103592 110210826
Gamma-glutamyltransferase increased 127.02 20.07 6 274875 61303 110253115
Transaminases increased 125.76 20.07 8 274873 63382 110251036
Injection site erythema 125.26 20.07 39 274842 94137 110220281
Altered state of consciousness 124.96 20.07 4 274877 57622 110256796
Suicidal ideation 124.77 20.07 39 274842 93898 110220520
Walking aid user 123.65 20.07 223 274658 24852 110289566
Neoplasm progression 122.84 20.07 10 274871 64585 110249833
Drug ineffective for unapproved indication 122.49 20.07 51 274830 102787 110211631
Melaena 121.92 20.07 14 274867 68743 110245675
Tachycardia 121.34 20.07 237 274644 226408 110088010
Abdominal pain 120.76 20.07 763 274118 512226 109802192
Pneumonia aspiration 120.65 20.07 27 274854 81206 110233212
Tubulointerstitial nephritis 120.54 20.07 3 274878 54281 110260137
Pancreatitis acute 118.41 20.07 8 274873 60266 110254152
Deep vein thrombosis 118.29 20.07 104 274777 139783 110174635
Drug hypersensitivity 118.24 20.07 1682 273199 452408 109862010
Cytomegalovirus infection 117.27 20.07 4 274877 54440 110259978
Hypothyroidism 117.17 20.07 20 274861 72879 110241539
Seronegative arthritis 117.17 20.07 154 274727 13023 110301395
Coeliac disease 116.76 20.07 301 274580 42886 110271532
Haematuria 116.62 20.07 31 274850 82974 110231444
Cerebral haemorrhage 115.77 20.07 13 274868 64955 110249463
Hepatic cirrhosis 114.97 20.07 400 274481 67226 110247192
Sedation 114.49 20.07 18 274863 69665 110244753
Liver function test abnormal 112.86 20.07 18 274863 68932 110245486
Joint dislocation 112.44 20.07 257 274624 33933 110280485
Lethargy 112.11 20.07 46 274835 93530 110220888
International normalised ratio increased 111.76 20.07 38 274843 86734 110227684
Hepatocellular injury 111.69 20.07 3 274878 50639 110263779
Hypertension 111.13 20.07 1833 273048 508251 109806167
Acute myocardial infarction 110.88 20.07 35 274846 83742 110230676
Blood alkaline phosphatase increased 110.68 20.07 21 274860 70914 110243504
Dry skin 109.27 20.07 66 274815 107587 110206831
Cardiogenic shock 108.69 20.07 9 274872 57329 110257089
Pneumonitis 108.63 20.07 28 274853 76503 110237915
Influenza like illness 108.31 20.07 42 274839 88370 110226048
Overdose 108.22 20.07 265 274616 233529 110080889
Hypomagnesaemia 107.78 20.07 12 274869 60358 110254060
Jaundice 107.74 20.07 11 274870 59225 110255193
Cerebral infarction 107.63 20.07 5 274876 51833 110262585
Product prescribing error 106.42 20.07 5 274876 51326 110263092
Eosinophilia 104.75 20.07 11 274870 57925 110256493
Orthostatic hypotension 104.68 20.07 19 274862 66230 110248188
Anaphylactic shock 103.78 20.07 6 274875 51540 110262878
Full blood count abnormal 103.01 20.07 10 274871 56042 110258376
Liver function test increased 102.27 20.07 464 274417 88084 110226334
Muscle spasms 102.03 20.07 1099 273782 277058 110037360
Acute respiratory distress syndrome 101.82 20.07 8 274873 53190 110261228
Eczema 101.56 20.07 27 274854 72266 110242152
Hallucination 100.44 20.07 64 274817 101368 110213050
Swelling face 100.33 20.07 52 274829 92269 110222149
Drug eruption 100.14 20.07 9 274872 53650 110260768
Haematemesis 100.04 20.07 14 274867 59094 110255324
Arthralgia 99.35 20.07 2588 272293 777044 109537374
Serotonin syndrome 97.82 20.07 15 274866 59138 110255280
Weight decreased 97.31 20.07 722 274159 467335 109847083
Cataract 96.97 20.07 38 274843 79447 110234971
Cystitis 95.98 20.07 23 274858 66013 110248405
Skin ulcer 94.83 20.07 21 274860 63624 110250794
C-reactive protein increased 94.34 20.07 891 273990 217028 110097390
Pallor 94.11 20.07 14 274867 56453 110257965
Intentional product misuse 94.08 20.07 115 274766 132789 110181629
Dyspepsia 94.04 20.07 803 274078 190162 110124256
Transient ischaemic attack 93.55 20.07 22 274859 63960 110250458
Blood lactate dehydrogenase increased 92.95 20.07 4 274877 44330 110270088
Paraesthesia 92.52 20.07 1073 273808 275448 110038970
Angina pectoris 91.92 20.07 21 274860 62274 110252144
Neurotoxicity 91.27 20.07 3 274878 42204 110272214
Aphasia 90.92 20.07 18 274863 58979 110255439
Respiratory distress 90.74 20.07 29 274852 68845 110245573
Red blood cell count decreased 90.03 20.07 26 274855 65897 110248521
Stevens-Johnson syndrome 89.91 20.07 7 274874 46894 110267524
Haematoma 89.78 20.07 18 274863 58458 110255960
Depressed mood 88.73 20.07 21 274860 60788 110253630
Amnesia 88.49 20.07 505 274376 104903 110209515
Bacteraemia 88.30 20.07 4 274877 42386 110272032
Swollen tongue 87.77 20.07 21 274860 60341 110254077
Diabetes mellitus 87.56 20.07 71 274810 99310 110215108
Lymphadenopathy 87.50 20.07 25 274856 63810 110250608
Chronic kidney disease 87.42 20.07 40 274841 76251 110238167
Osteonecrosis of jaw 87.11 20.07 9 274872 48008 110266410
Mental status changes 87.09 20.07 40 274841 76082 110238336
Hypercalcaemia 86.60 20.07 8 274873 46649 110267769
Bone pain 86.57 20.07 27 274854 65106 110249312
Lymphopenia 86.35 20.07 3 274878 40167 110274251
Blood urea increased 86.32 20.07 16 274865 54941 110259477
Pneumocystis jirovecii pneumonia 85.96 20.07 5 274876 42730 110271688
Haemoptysis 85.60 20.07 35 274846 71319 110243099
Dyskinesia 85.18 20.07 13 274868 51433 110262985
Ear infection 84.98 20.07 345 274536 62387 110252031
Disturbance in attention 83.66 20.07 25 274856 61970 110252448
Generalised tonic-clonic seizure 83.60 20.07 17 274864 54663 110259755
Hypophagia 83.35 20.07 15 274866 52611 110261807
Cardiac disorder 82.84 20.07 43 274838 76237 110238181
Ventricular fibrillation 82.59 20.07 5 274876 41308 110273110
Disseminated intravascular coagulation 82.53 20.07 5 274876 41281 110273137
Dysphonia 82.17 20.07 43 274838 75886 110238532
Arrhythmia 82.06 20.07 35 274846 69540 110244878
Haematocrit decreased 81.67 20.07 31 274850 66086 110248332
Subcutaneous drug absorption impaired 81.63 20.07 98 274783 7561 110306857
Coronary artery disease 81.51 20.07 38 274843 71652 110242766
Shock 81.23 20.07 17 274864 53571 110260847
Basal cell carcinoma 80.81 20.07 9 274872 45261 110269157
Tinnitus 80.63 20.07 25 274856 60515 110253903
Mouth ulceration 80.08 20.07 12 274869 48126 110266292
Ventricular tachycardia 79.75 20.07 14 274867 49995 110264423
Staphylococcal infection 79.64 20.07 37 274844 69907 110244511
Presyncope 79.48 20.07 13 274868 48874 110265544
Speech disorder 79.22 20.07 27 274854 61542 110252876
Drug level increased 79.14 20.07 12 274869 47707 110266711
Drug tolerance decreased 78.67 20.07 196 274685 27344 110287074
Plasma cell myeloma 78.59 20.07 29 274852 62907 110251511
Acute myeloid leukaemia 78.08 20.07 4 274877 38106 110276312
Injection site swelling 77.96 20.07 28 274853 61762 110252656
Ulcer haemorrhage 76.82 20.07 172 274709 22399 110292019
Intentional self-injury 76.46 20.07 4 274877 37425 110276993
Ejection fraction decreased 75.90 20.07 7 274874 40873 110273545
Ulcer 75.89 20.07 9 274872 43107 110271311
Pericardial effusion 75.54 20.07 24 274857 57193 110257225
Nephrolithiasis 75.43 20.07 35 274846 66177 110248241
Rash erythematous 75.21 20.07 56 274825 81776 110232642
Burning sensation 75.19 20.07 39 274842 69173 110245245
Red blood cell sedimentation rate increased 75.08 20.07 389 274492 77913 110236505
Dysuria 74.80 20.07 28 274853 60203 110254215
Anaphylactic reaction 74.65 20.07 105 274776 114195 110200223
Infusion site reaction 74.45 20.07 147 274734 17535 110296883
Multiple sclerosis relapse 74.00 20.07 17 274864 50223 110264195
Restlessness 73.56 20.07 24 274857 56235 110258183
Diabetic ketoacidosis 73.49 20.07 9 274872 42049 110272369
Therapy interrupted 73.10 20.07 17 274864 49805 110264613
Skin lesion 73.06 20.07 19 274862 51612 110262806
Hepatic steatosis 72.97 20.07 16 274865 48815 110265603
Abortion spontaneous 72.18 20.07 3 274878 34279 110280139
Proteinuria 71.32 20.07 8 274873 40010 110274408
Lip swelling 71.02 20.07 19 274862 50648 110263770
Localised infection 70.99 20.07 11 274870 43037 110271381
Dysgeusia 70.89 20.07 43 274838 69942 110244476
Clostridium difficile colitis 70.38 20.07 12 274869 43766 110270652
Disability 70.01 20.07 199 274682 30024 110284394
Therapy non-responder 69.97 20.07 647 274234 156660 110157758
Acute respiratory failure 69.82 20.07 51 274830 75209 110239209
Upper gastrointestinal haemorrhage 69.82 20.07 19 274862 50077 110264341
Blood pressure diastolic decreased 69.80 20.07 5 274876 35880 110278538
Drug dependence 69.66 20.07 19 274862 50001 110264417
Aggression 69.49 20.07 30 274851 59180 110255238
Ischaemic stroke 69.30 20.07 10 274871 41253 110273165
Hot flush 69.12 20.07 39 274842 65997 110248421
Myoclonus 69.11 20.07 3 274878 32995 110281423
Swollen joint count 68.95 20.07 96 274785 8578 110305840
Urinary retention 68.94 20.07 44 274837 69639 110244779
Palmar-plantar erythrodysaesthesia syndrome 68.77 20.07 10 274871 41015 110273403
Adverse reaction 68.69 20.07 195 274686 29399 110285019
Prostate cancer 68.43 20.07 7 274874 37634 110276784
Gastritis 68.32 20.07 24 274857 53675 110260743
Pulmonary hypertension 68.02 20.07 26 274855 55194 110259224
Device related infection 67.73 20.07 9 274872 39510 110274908
Osteonecrosis 67.71 20.07 4 274877 33737 110280681
Dyspnoea 67.11 20.07 2169 272712 1104703 109209715
Neutrophil count increased 66.91 20.07 5 274876 34647 110279771
Leukocytosis 66.88 20.07 25 274856 53803 110260615
Clostridium difficile infection 66.83 20.07 23 274858 52106 110262312
Body temperature decreased 66.80 20.07 7 274874 36928 110277490
Respiratory depression 66.72 20.07 3 274878 31998 110282420
Renal disorder 66.68 20.07 20 274861 49459 110264959
Hypocalcaemia 66.44 20.07 40 274841 65326 110249092
Hemiparesis 66.39 20.07 14 274867 43889 110270529
Nightmare 66.25 20.07 9 274872 38854 110275564
Coagulopathy 66.24 20.07 11 274870 40900 110273518
Illness 66.01 20.07 64 274817 82107 110232311
Sopor 65.91 20.07 7 274874 36539 110277879
Skin discolouration 65.78 20.07 20 274861 49026 110265392
Status epilepticus 65.69 20.07 3 274878 31568 110282850
Myelodysplastic syndrome 65.54 20.07 8 274873 37476 110276942
Rhinorrhoea 65.38 20.07 96 274785 102570 110211848
Obstructive airways disorder 65.27 20.07 17 274864 46132 110268286
Peritonitis 65.02 20.07 4 274877 32603 110281815
Diverticulitis 64.61 20.07 26 274855 53496 110260922
Electrolyte imbalance 64.51 20.07 8 274873 37020 110277398
Therapy cessation 64.45 20.07 16 274865 44841 110269577
Eye pain 64.41 20.07 22 274859 50077 110264341
Psychotic disorder 64.40 20.07 23 274858 50914 110263504
Neutropenic sepsis 63.72 20.07 3 274878 30743 110283675
Polyneuropathy 63.62 20.07 4 274877 32008 110282410
Hypophosphataemia 63.47 20.07 5 274876 33177 110281241
Premature delivery 63.45 20.07 3 274878 30629 110283789
Injection site bruising 63.37 20.07 24 274857 51239 110263179
Hallucination, visual 63.35 20.07 11 274870 39594 110274824
Metastases to liver 63.25 20.07 7 274874 35379 110279039
Acute hepatic failure 63.24 20.07 8 274873 36460 110277958
Cytopenia 62.22 20.07 3 274878 30113 110284305
Diplopia 62.05 20.07 14 274867 41880 110272538
Candida infection 61.86 20.07 21 274860 47988 110266430
Gastroenteritis 61.57 20.07 11 274870 38789 110275629
Subarachnoid haemorrhage 61.23 20.07 3 274878 29699 110284719
Neuralgia 61.10 20.07 22 274859 48456 110265962
Blindness 60.63 20.07 9 274872 36350 110278068
Urosepsis 60.47 20.07 4 274877 30671 110283747
Hyperbilirubinaemia 60.46 20.07 4 274877 30667 110283751
Nervous system disorder 60.07 20.07 5 274876 31716 110282702
Sinus tachycardia 59.93 20.07 18 274863 44475 110269943
Femur fracture 59.88 20.07 18 274863 44451 110269967
Posterior reversible encephalopathy syndrome 59.77 20.07 7 274874 33854 110280564
Gastric ulcer 59.62 20.07 13 274868 39814 110274604
Haemorrhage intracranial 59.48 20.07 3 274878 28966 110285452
Glomerular filtration rate decreased 59.45 20.07 3 274878 28953 110285465
Fungal infection 59.21 20.07 26 274855 50780 110263638
Visual acuity reduced 58.44 20.07 6 274875 32167 110282251
Hepatic encephalopathy 57.78 20.07 3 274878 28253 110286165
Unevaluable event 57.77 20.07 38 274843 59189 110255229
Cholelithiasis 57.52 20.07 44 274837 63378 110251040
Blood calcium decreased 57.24 20.07 10 274871 35835 110278583
Underdose 57.00 20.07 310 274571 63244 110251174
Tachypnoea 56.70 20.07 14 274867 39381 110275037
Grip strength 56.62 20.07 90 274791 9051 110305367
Cardiomyopathy 56.59 20.07 8 274873 33517 110280901
Productive cough 56.53 20.07 125 274756 114180 110200238
Irritability 56.46 20.07 24 274857 47785 110266633
Gastrooesophageal reflux disease 56.04 20.07 689 274192 179287 110135131
Toxic epidermal necrolysis 55.87 20.07 36 274845 56691 110257727
Joint stiffness 55.67 20.07 321 274560 66922 110247496
Injection site pruritus 55.50 20.07 29 274852 51229 110263189
Appendicitis 55.27 20.07 4 274877 28460 110285958
Vasculitis 55.16 20.07 11 274870 35862 110278556
Blood potassium decreased 55.16 20.07 33 274848 54081 110260337
Acne 54.30 20.07 9 274872 33511 110280907
Throat irritation 54.10 20.07 33 274848 53519 110260899
COVID-19 pneumonia 53.85 20.07 13 274868 37130 110277288
Hypervolaemia 53.53 20.07 28 274853 49432 110264986
Viral infection 53.33 20.07 33 274848 53106 110261312
Troponin increased 52.92 20.07 6 274875 29760 110284658
Normal newborn 52.51 20.07 146 274735 21750 110292668
Malnutrition 52.49 20.07 4 274877 27275 110287143
Subdural haematoma 52.38 20.07 13 274868 36441 110277977
Spondylitis 52.33 20.07 98 274783 11240 110303178
Renal tubular necrosis 52.09 20.07 7 274874 30468 110283950
Nail operation 52.03 20.07 39 274842 1655 110312763
Face oedema 52.02 20.07 10 274871 33459 110280959
Pruritus 52.00 20.07 1849 273032 579711 109734707
Neoplasm malignant 51.93 20.07 14 274867 37129 110277289
Pneumothorax 51.85 20.07 12 274869 35273 110279145
Withdrawal syndrome 51.79 20.07 8 274873 31372 110283046
Head injury 51.76 20.07 21 274860 42996 110271422
Dry eye 51.50 20.07 38 274843 55755 110258663
Brain oedema 51.16 20.07 8 274873 31090 110283328
Hypoalbuminaemia 51.12 20.07 6 274875 28968 110285450
Injection site haemorrhage 51.05 20.07 10 274871 33018 110281400
Hypocholesterolaemia 50.94 20.07 71 274810 6350 110308068
Unresponsive to stimuli 50.87 20.07 50 274831 63740 110250678
Device expulsion 50.70 20.07 8 274873 30883 110283535
Abdominal pain lower 50.37 20.07 15 274866 37268 110277150
Therapeutic response shortened 50.08 20.07 7 274874 29576 110284842
Sinus bradycardia 49.85 20.07 7 274874 29476 110284942
Accidental overdose 49.56 20.07 34 274847 51800 110262618
Fracture 49.55 20.07 3 274878 24785 110289633
Labelled drug-drug interaction medication error 49.45 20.07 7 274874 29295 110285123
Gout 48.88 20.07 15 274866 36551 110277867
Abnormal behaviour 48.72 20.07 18 274863 39021 110275397
Hepatic enzyme 48.49 20.07 62 274819 5101 110309317
Product administration error 48.44 20.07 16 274865 37201 110277217
Mental disorder 48.22 20.07 18 274863 38773 110275645
Ileus 48.14 20.07 9 274872 30720 110283698
Dementia 48.10 20.07 10 274871 31663 110282755
Generalised oedema 48.09 20.07 9 274872 30695 110283723
Oral herpes 47.87 20.07 15 274866 36065 110278353
Insomnia 47.81 20.07 1204 273677 359386 109955032
Respiratory arrest 47.30 20.07 45 274836 58254 110256164
Escherichia infection 47.26 20.07 3 274878 23813 110290605
Progressive multifocal leukoencephalopathy 47.07 20.07 4 274877 24952 110289466
Dysstasia 46.94 20.07 12 274869 32974 110281444
Delirium 46.93 20.07 528 274353 134497 110179921
General symptom 46.62 20.07 81 274800 8765 110305653
Device issue 46.46 20.07 14 274867 34521 110279897
Pollakiuria 46.40 20.07 26 274855 44169 110270249
Extrapyramidal disorder 46.21 20.07 8 274873 28859 110285559
Breast cancer 46.07 20.07 19 274862 38523 110275895
Photosensitivity reaction 45.89 20.07 5 274876 25584 110288834
Joint injury 45.77 20.07 21 274860 39973 110274445
Intestinal obstruction 45.68 20.07 39 274842 53188 110261230
Anuria 45.64 20.07 4 274877 24337 110290081
Blood potassium increased 45.61 20.07 13 274868 33236 110281182
Osteomyelitis 45.47 20.07 17 274864 36583 110277835
Metastases to bone 45.44 20.07 11 274870 31361 110283057
Hypothermia 45.05 20.07 6 274875 26296 110288122
Urinary incontinence 44.97 20.07 33 274848 48554 110265864
Hemiplegia 44.82 20.07 3 274878 22779 110291639
Rash macular 44.76 20.07 20 274861 38666 110275752
Disease recurrence 44.72 20.07 51 274830 60733 110253685
Rash pruritic 44.69 20.07 112 274769 97957 110216461
Mental impairment 44.48 20.07 3 274878 22636 110291782
Eating disorder 44.35 20.07 11 274870 30847 110283571
Muscle twitching 44.34 20.07 10 274871 29925 110284493
Bacterial infection 44.28 20.07 30 274851 46006 110268412
Heart rate irregular 44.15 20.07 15 274866 34259 110280159
Immune thrombocytopenia 44.14 20.07 3 274878 22491 110291927
Rales 43.95 20.07 5 274876 24734 110289684
Dystonia 43.93 20.07 6 274875 25799 110288619
Cyanosis 43.93 20.07 10 274871 29731 110284687
Accidental exposure to product 43.70 20.07 36 274845 49972 110264446
Bronchiectasis 43.61 20.07 18 274863 36475 110277943
Faeces discoloured 43.48 20.07 15 274866 33933 110280485
Motor dysfunction 43.19 20.07 5 274876 24401 110290017
Abscess 43.13 20.07 8 274873 27461 110286957
Skin laceration 43.08 20.07 15 274866 33738 110280680
Breath sounds abnormal 43.03 20.07 6 274875 25398 110289020
Schizophrenia 42.57 20.07 3 274878 21823 110292595
Hypokinesia 42.57 20.07 3 274878 21823 110292595
Injection site reaction 42.49 20.07 372 274509 88698 110225720
Muscle rigidity 42.34 20.07 5 274876 24026 110290392
Hypovolaemia 42.21 20.07 3 274878 21671 110292747
Pain in jaw 42.11 20.07 39 274842 51138 110263280
Pulmonary mass 42.05 20.07 20 274861 37281 110277137
Asthma 42.00 20.07 864 274017 249427 110064991
Feeling cold 41.86 20.07 16 274865 33971 110280447
Skin haemorrhage 41.73 20.07 6 274875 24821 110289597
Small intestinal obstruction 41.66 20.07 14 274867 32199 110282219
Feeding disorder 41.48 20.07 3 274878 21359 110293059
Flatulence 41.44 20.07 41 274840 52108 110262310
Blood albumin decreased 41.44 20.07 9 274872 27643 110286775
Neck pain 41.23 20.07 478 274403 122652 110191766
Pustular psoriasis 41.17 20.07 99 274782 13506 110300912
Splenomegaly 40.99 20.07 6 274875 24492 110289926
Surgery 40.93 20.07 26 274855 41257 110273161
Eosinophil count increased 40.77 20.07 3 274878 21055 110293363
Purpura 40.75 20.07 6 274875 24382 110290036
Device dislocation 40.62 20.07 14 274867 31690 110282728
Intestinal perforation 40.50 20.07 3 274878 20941 110293477
Panic attack 40.28 20.07 11 274870 28929 110285489
Product substitution issue 40.13 20.07 5 274876 23056 110291362
Cardiac failure acute 40.05 20.07 6 274875 24072 110290346
Ocular hyperaemia 39.98 20.07 24 274857 39262 110275156
Lung neoplasm malignant 39.94 20.07 17 274864 33825 110280593
Skin disorder 39.91 20.07 29 274852 42884 110271534
Pseudomonas infection 39.89 20.07 10 274871 27843 110286575
Drug ineffective 39.77 20.07 3248 271633 1517292 108797126
Limb injury 39.71 20.07 22 274859 37614 110276804
Metastases to central nervous system 39.58 20.07 5 274876 22812 110291606
Blood test abnormal 39.47 20.07 11 274870 28543 110285875
Medication error 39.37 20.07 418 274463 104948 110209470
Myocardial ischaemia 39.36 20.07 9 274872 26675 110287743
Chromaturia 39.32 20.07 12 274869 29348 110285070
Blood uric acid increased 39.14 20.07 4 274877 21525 110292893
Skin necrosis 39.10 20.07 4 274877 21508 110292910
Overlap syndrome 38.97 20.07 76 274805 8983 110305435
Hepatomegaly 38.88 20.07 4 274877 21410 110293008
Impaired work ability 38.79 20.07 9 274872 26410 110288008
Chronic obstructive pulmonary disease 38.72 20.07 140 274741 109018 110205400
Atrioventricular block complete 38.49 20.07 3 274878 20079 110294339
Hypertensive crisis 38.48 20.07 7 274874 24365 110290053
Hypogammaglobulinaemia 38.47 20.07 3 274878 20073 110294345
Klebsiella infection 38.31 20.07 3 274878 20006 110294412
Pyelonephritis 38.29 20.07 8 274873 25242 110289176
Coordination abnormal 38.24 20.07 8 274873 25220 110289198
Rib fracture 38.23 20.07 18 274863 33752 110280666
Erythema multiforme 38.15 20.07 4 274877 21093 110293325
Osteoporosis 38.01 20.07 357 274524 86795 110227623
Urine output decreased 38.00 20.07 3 274878 19873 110294545
Hypoacusis 37.97 20.07 20 274861 35171 110279247
Hip fracture 37.89 20.07 20 274861 35131 110279287
Drug withdrawal syndrome 37.68 20.07 24 274857 38030 110276388
Nasal congestion 37.61 20.07 122 274759 98160 110216258
Penile abscess 37.50 20.07 14 274867 132 110314286
Sudden infant death syndrome 37.45 20.07 18 274863 331 110314087
Rash vesicular 37.43 20.07 100 274781 14552 110299866
Mass 37.43 20.07 3 274878 19627 110294791
Pulmonary arterial hypertension 37.43 20.07 17 274864 32551 110281867
Ataxia 37.38 20.07 14 274867 30094 110284324
Delusion 37.12 20.07 7 274874 23748 110290670
Cardiovascular disorder 37.11 20.07 6 274875 22754 110291664
Kidney infection 37.03 20.07 9 274872 25590 110288828
Cardiac murmur 36.94 20.07 8 274873 24620 110289798
Poor venous access 36.71 20.07 8 274873 24514 110289904
Sensory loss 36.50 20.07 5 274876 21452 110292966
Sudden death 36.44 20.07 8 274873 24387 110290031
Activated partial thromboplastin time prolonged 36.24 20.07 6 274875 22362 110292056
Oesophagitis 36.24 20.07 13 274868 28702 110285716
Respiratory rate increased 35.93 20.07 9 274872 25074 110289344
Mydriasis 35.78 20.07 6 274875 22151 110292267
Acute coronary syndrome 35.72 20.07 7 274874 23105 110291313
Food allergy 35.52 20.07 4 274877 19944 110294474
Hepatitis acute 35.42 20.07 3 274878 18763 110295655
Miosis 35.39 20.07 6 274875 21977 110292441
Vomiting 35.34 20.07 1877 273004 908798 109405620
Atelectasis 35.21 20.07 24 274857 36688 110277730
Hallucination, auditory 34.97 20.07 11 274870 26386 110288032
Injection site mass 34.93 20.07 9 274872 24604 110289814
Uveitis 34.79 20.07 6 274875 21704 110292714
Squamous cell carcinoma 34.71 20.07 3 274878 18460 110295958
Dermatitis 34.46 20.07 13 274868 27824 110286594
Acidosis 34.45 20.07 7 274874 22524 110291894
Mitral valve incompetence 34.43 20.07 20 274861 33309 110281109
Bronchospasm 34.42 20.07 16 274865 30223 110284195
Treatment noncompliance 34.32 20.07 82 274799 72908 110241510
Tendonitis 34.32 20.07 11 274870 26072 110288346
Blood sodium decreased 34.22 20.07 27 274854 38292 110276126
Micturition urgency 34.08 20.07 4 274877 19316 110295102
Cholecystitis 33.91 20.07 11 274870 25871 110288547
Psychomotor hyperactivity 33.85 20.07 5 274876 20272 110294146
Eye pruritus 33.38 20.07 20 274861 32755 110281663
Device malfunction 33.24 20.07 11 274870 25547 110288871
Lung infiltration 33.10 20.07 10 274871 24618 110289800
Encephalitis 32.99 20.07 4 274877 18835 110295583
Glycosylated haemoglobin increased 32.83 20.07 9 274872 23610 110290808
Lacrimation increased 32.79 20.07 18 274863 30932 110283486
Musculoskeletal disorder 32.72 20.07 8 274873 22656 110291762
Renal injury 32.70 20.07 4 274877 18709 110295709
Affect lability 32.53 20.07 4 274877 18633 110295785
Conjunctivitis 32.53 20.07 22 274859 33770 110280648
Iron deficiency anaemia 32.51 20.07 19 274862 31540 110282878
Joint destruction 32.44 20.07 79 274802 10864 110303554
Staphylococcal sepsis 32.37 20.07 3 274878 17451 110296967
Right ventricular failure 32.33 20.07 12 274869 25942 110288476
Cardiomegaly 32.26 20.07 16 274865 29114 110285304
Petechiae 32.20 20.07 9 274872 23308 110291110
Full blood count decreased 32.12 20.07 20 274861 32079 110282339
Eye irritation 31.90 20.07 22 274859 33430 110280988
Enterococcal infection 31.83 20.07 6 274875 20360 110294058
Blood triglycerides increased 31.65 20.07 10 274871 23916 110290502
Tooth disorder 31.50 20.07 17 274864 29492 110284926
Lymphoma 31.40 20.07 6 274875 20165 110294253
Oral candidiasis 31.38 20.07 39 274842 44721 110269697
Transfusion 31.36 20.07 12 274869 25460 110288958
Nocturia 31.30 20.07 3 274878 16987 110297431
Pain of skin 31.09 20.07 6 274875 20023 110294395
Spinal fracture 30.77 20.07 9 274872 22624 110291794
Poisoning 30.73 20.07 17 274864 29088 110285330
Throat tightness 30.66 20.07 23 274858 33466 110280952
Injection site rash 30.60 20.07 10 274871 23409 110291009
Device difficult to use 30.57 20.07 5 274876 18800 110295618
Facial paralysis 30.50 20.07 11 274870 24203 110290215
Polyuria 30.49 20.07 4 274877 17734 110296684
Electrocardiogram abnormal 30.36 20.07 5 274876 18704 110295714
Blood pressure abnormal 30.33 20.07 9 274872 22415 110292003
Poor quality sleep 30.23 20.07 16 274865 28061 110286357
Colon cancer 30.04 20.07 3 274878 16440 110297978
Blood glucose decreased 30.03 20.07 18 274863 29470 110284948
Asthenia 30.01 20.07 1403 273478 687596 109626822
Arteriosclerosis 29.94 20.07 12 274869 24755 110289663
Hernia 29.94 20.07 6 274875 19494 110294924
Lower gastrointestinal haemorrhage 29.86 20.07 5 274876 18481 110295937
Gangrene 29.80 20.07 3 274878 16338 110298080
Cholangitis 29.79 20.07 3 274878 16332 110298086
Injection site warmth 29.74 20.07 4 274877 17401 110297017
Eye injury 29.71 20.07 62 274819 7693 110306725
Immune reconstitution inflammatory syndrome 29.54 20.07 3 274878 16223 110298195
Respiratory tract infection 29.46 20.07 86 274795 71531 110242887
Escherichia urinary tract infection 29.39 20.07 3 274878 16159 110298259
Hypertriglyceridaemia 29.37 20.07 3 274878 16151 110298267
Hiatus hernia 29.33 20.07 16 274865 27590 110286828
Ventricular extrasystoles 29.00 20.07 10 274871 22631 110291787
Ear pain 28.96 20.07 229 274652 52997 110261421
Atrial flutter 28.94 20.07 12 274869 24250 110290168
Product storage error 28.88 20.07 9 274872 21719 110292699
Stress cardiomyopathy 28.57 20.07 3 274878 15803 110298615
Respiratory disorder 28.47 20.07 287 274594 71095 110243323
Hypotonia 28.43 20.07 3 274878 15742 110298676
Needle issue 28.43 20.07 5 274876 17835 110296583
Depression 28.32 20.07 1009 273872 316326 109998092
Diarrhoea haemorrhagic 28.19 20.07 3 274878 15636 110298782
Tricuspid valve incompetence 28.16 20.07 12 274869 23861 110290557
Neurological symptom 28.12 20.07 3 274878 15605 110298813
Erectile dysfunction 27.89 20.07 6 274875 18550 110295868
Spinal pain 27.80 20.07 6 274875 18509 110295909
Iron deficiency 27.72 20.07 6 274875 18470 110295948
Supraventricular tachycardia 27.67 20.07 13 274868 24409 110290009
Sleep apnoea syndrome 27.57 20.07 36 274845 40411 110274007
Spinal compression fracture 27.53 20.07 6 274875 18386 110296032
Sensory disturbance 27.53 20.07 5 274876 17424 110296994
Vaginal haemorrhage 27.42 20.07 14 274867 25060 110289358
Skin burning sensation 27.34 20.07 10 274871 21815 110292603
Tenosynovitis 27.22 20.07 4 274877 16279 110298139
Toxic encephalopathy 27.22 20.07 3 274878 15211 110299207
Sputum discoloured 27.16 20.07 18 274863 27927 110286491
Dermatitis allergic 27.14 20.07 10 274871 21714 110292704
Fear 26.82 20.07 12 274869 23181 110291237
Paranoia 26.79 20.07 11 274870 22363 110292055
Pneumonia bacterial 26.78 20.07 16 274865 26245 110288173
Intervertebral disc protrusion 26.70 20.07 18 274863 27680 110286738
Device leakage 26.69 20.07 4 274877 16044 110298374
Bone density decreased 26.68 20.07 4 274877 16038 110298380
Respiratory symptom 26.60 20.07 3 274878 14942 110299476
Hypernatraemia 26.33 20.07 6 274875 17827 110296591
Eye swelling 26.24 20.07 26 274855 33022 110281396
Haemorrhoids 26.16 20.07 30 274851 35642 110278776
Pulmonary toxicity 26.14 20.07 6 274875 17740 110296678
Post procedural complication 26.14 20.07 17 274864 26641 110287777
Herpes simplex 26.06 20.07 4 274877 15760 110298658
Postoperative wound infection 26.03 20.07 4 274877 15749 110298669
Gingival pain 26.00 20.07 4 274877 15732 110298686
Spinal fusion surgery 25.98 20.07 65 274816 9091 110305327
Product dose omission in error 25.91 20.07 13 274868 23499 110290919
Blood urine present 25.83 20.07 14 274867 24231 110290187
Retching 25.82 20.07 12 274869 22670 110291748
Multiple sclerosis 25.73 20.07 16 274865 25682 110288736
Product use in unapproved indication 25.71 20.07 1359 273522 446018 109868400
Drug dose omission by device 25.62 20.07 3 274878 14513 110299905
Fatigue 25.49 20.07 3421 271460 1212537 109101881
Glaucoma 25.49 20.07 12 274869 22505 110291913
Complication associated with device 25.48 20.07 9 274872 20064 110294354
Skin infection 25.48 20.07 12 274869 22497 110291921
Flank pain 25.17 20.07 13 274868 23117 110291301
Product dispensing error 25.15 20.07 5 274876 16340 110298078
Arterial occlusive disease 25.04 20.07 4 274877 15304 110299114
Eye disorder 25.02 20.07 21 274860 28885 110285533
Fistula 25.02 20.07 4 274877 15295 110299123
Hydronephrosis 25.00 20.07 10 274871 20655 110293763
Squamous cell carcinoma of skin 24.98 20.07 6 274875 17197 110297221
Asphyxia 24.94 20.07 3 274878 14212 110300206
Procedural pain 24.92 20.07 31 274850 35534 110278884
Skin fissures 24.81 20.07 15 274866 24443 110289975
Odynophagia 24.68 20.07 3 274878 14098 110300320
Pharyngitis 24.62 20.07 16 274865 25082 110289336
Ageusia 24.61 20.07 9 274872 19636 110294782
Mood swings 24.56 20.07 13 274868 22799 110291619
Impaired quality of life 24.55 20.07 23 274858 29994 110284424
Acute pulmonary oedema 24.54 20.07 6 274875 16990 110297428
Bone disorder 24.45 20.07 11 274870 21181 110293237
Duodenal ulcer 24.35 20.07 9 274872 19505 110294913
Malignant melanoma 24.31 20.07 6 274875 16885 110297533
Increased appetite 24.31 20.07 4 274877 14973 110299445
Cardiotoxicity 24.29 20.07 6 274875 16875 110297543
Immunosuppression 24.25 20.07 7 274874 17752 110296666
Muscular weakness 24.16 20.07 798 274083 247670 110066748
Peripheral coldness 24.08 20.07 8 274873 18532 110295886
Pulseless electrical activity 24.03 20.07 6 274875 16751 110297667
Red cell distribution width increased 23.93 20.07 7 274874 17595 110296823
Autoimmune hepatitis 23.92 20.07 4 274877 14800 110299618
Staphylococcal bacteraemia 23.88 20.07 6 274875 16682 110297736
Acute generalised exanthematous pustulosis 23.84 20.07 12 274869 21652 110292766
Pulmonary haemorrhage 23.39 20.07 6 274875 16450 110297968
Angina unstable 23.34 20.07 6 274875 16426 110297992
Hyperlipidaemia 23.33 20.07 33 274848 35815 110278603
Ankle fracture 23.32 20.07 10 274871 19809 110294609
Brain injury 23.26 20.07 3 274878 13473 110300945
Nephropathy 23.24 20.07 3 274878 13464 110300954
Blood pressure systolic decreased 23.18 20.07 3 274878 13438 110300980
Aspiration 23.14 20.07 25 274856 30508 110283910
Injection site urticaria 23.12 20.07 7 274874 17208 110297210
Emotional distress 23.04 20.07 48 274833 44799 110269619
Eyelid ptosis 22.92 20.07 3 274878 13324 110301094
Rhinitis 22.62 20.07 14 274867 22531 110291887
Parosmia 22.59 20.07 3 274878 13177 110301241
Forced expiratory volume decreased 22.58 20.07 3 274878 13173 110301245
Respiratory tract congestion 22.58 20.07 26 274855 30831 110283587
Drug effective for unapproved indication 22.52 20.07 4 274877 14163 110300255
Gastric disorder 22.42 20.07 30 274851 33327 110281091
Vitamin D deficiency 22.41 20.07 9 274872 18543 110295875
Aortic stenosis 22.32 20.07 3 274878 13056 110301362
Eructation 22.27 20.07 4 274877 14053 110300365
Blood magnesium decreased 22.12 20.07 11 274870 19985 110294433
Arteriosclerosis coronary artery 22.05 20.07 18 274863 25100 110289318
Blood lactic acid increased 22.05 20.07 6 274875 15815 110298603
Osteopenia 22.00 20.07 14 274867 22195 110292223
Nervousness 21.98 20.07 36 274845 36815 110277603
Cholecystitis acute 21.96 20.07 6 274875 15776 110298642
Oral pain 21.95 20.07 37 274844 37407 110277011
Mood altered 21.83 20.07 13 274868 21362 110293056
Rebound effect 21.82 20.07 5 274876 14801 110299617
Decubitus ulcer 21.78 20.07 9 274872 18227 110296191
Caesarean section 21.75 20.07 4 274877 13813 110300605
Haemorrhagic stroke 21.68 20.07 4 274877 13785 110300633
Haemolysis 21.66 20.07 6 274875 15633 110298785
Paralysis 21.58 20.07 6 274875 15594 110298824
Central nervous system lesion 21.48 20.07 6 274875 15547 110298871
Heavy menstrual bleeding 21.36 20.07 7 274874 16358 110298060
Hypovolaemic shock 21.35 20.07 5 274876 14578 110299840
Hepatitis C 21.22 20.07 3 274878 12570 110301848
Paraesthesia oral 20.93 20.07 32 274849 33639 110280779
Pleuritic pain 20.90 20.07 7 274874 16133 110298285
Bedridden 20.89 20.07 4 274877 13421 110300997
Skin cancer 20.88 20.07 9 274872 17775 110296643
Diastolic dysfunction 20.84 20.07 3 274878 12401 110302017
Suspected suicide 20.74 20.07 6 274875 15193 110299225
Tongue disorder 20.74 20.07 5 274876 14293 110300125
Pulmonary congestion 20.66 20.07 28 274853 30938 110283480
Blood thyroid stimulating hormone increased 20.61 20.07 3 274878 12298 110302120
Choking 20.56 20.07 6 274875 15104 110299314
Musculoskeletal discomfort 20.50 20.07 17 274864 23521 110290897
Left ventricular hypertrophy 20.49 20.07 4 274877 13240 110301178
Quality of life decreased 20.46 20.07 5 274876 14164 110300254
Gastric haemorrhage 20.44 20.07 7 274874 15908 110298510
Vitamin D decreased 20.42 20.07 3 274878 12212 110302206
Anal incontinence 20.22 20.07 15 274866 21949 110292469
Anger 20.22 20.07 11 274870 18996 110295422
Sleep disorder due to general medical condition, hypersomnia type 20.16 20.07 25 274856 1994 110312424
Musculoskeletal deformity 20.15 20.07 22 274859 1531 110312887
Gastrointestinal infection 20.11 20.07 5 274876 14000 110300418
Exercise tolerance decreased 20.09 20.07 3 274878 12064 110302354

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R01BA02 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
ATC R01BA52 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
FDA MoA N0000000209 Adrenergic alpha-Agonists
FDA EPC N0000175552 alpha-Adrenergic Agonist
CHEBI has role CHEBI:76924 plant metabolite
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014662 Vasoconstrictor Agents
MeSH PA D014663 Nasal Decongestants
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:35470 central nervous system drug
CHEBI has role CHEBI:35523 bronchodilator agent
CHEBI has role CHEBI:35524 sympathomimetic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:49167 anti-asthmatic drug
CHEBI has role CHEBI:50514 vasoconstrictor agent
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:77715 nasal decongestant

Related Drugs by ATC class:

R01BA Sympathomimetics 2 drugs
phenylephrinephenylpropanolamine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Common cold indication 82272006 DOID:10459
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Eustachian Tube Congestion indication
Brain damage contraindication 2470005
Ocular hypertension contraindication 4210003 DOID:9282
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Disorder of autonomic nervous system contraindication 15241006
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypovolemic shock contraindication 39419009
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Third trimester pregnancy contraindication 41587001
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Gastrointestinal perforation contraindication 51875005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Multiple organ failure contraindication 57653000
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Poisoning by acetaminophen contraindication 70273001
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Liver function tests abnormal contraindication 166603001
Cystic fibrosis contraindication 190905008 DOID:1485
Drug-induced psychosis contraindication 191483003 DOID:1742
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Myocardial dysfunction contraindication 233928007
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Sepsis syndrome contraindication 238150007
Rhabdomyolysis contraindication 240131006
Pyloric obstruction contraindication 244815007
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Drowsy contraindication 271782001
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thromboembolic disorder contraindication 371039008
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Smoking cessation assistance contraindication 384742004
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Traumatic injury contraindication 417746004
Central nervous system depression contraindication 418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Fever greater than 100.4 Fahrenheit contraindication 426000000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
Acute Thromboembolic Stroke contraindication
Theophylline Toxicity contraindication
Severe Hypoxemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.22 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter RELEASING AGENT CHEMBL CHEMBL
Beta-2 adrenergic receptor GPCR WOMBAT-PK
Alpha-2A adrenergic receptor GPCR WOMBAT-PK
Alpha-1A adrenergic receptor GPCR WOMBAT-PK

External reference:

IDSource
4018571 VUID
N0000178581 NUI
D00485 KEGG_DRUG
345-78-8 SECONDARY_CAS_RN
7460-12-0 SECONDARY_CAS_RN
4018043 VANDF
4018571 VANDF
4018802 VANDF
C0033798 UMLSCUI
CHEBI:51209 CHEBI
CHEMBL1590 ChEMBL_ID
DB00852 DRUGBANK_ID
CHEMBL1200724 ChEMBL_ID
CHEMBL3989855 ChEMBL_ID
D054199 MESH_DESCRIPTOR_UI
7028 PUBCHEM_CID
1061 INN_ID
7286 IUPHAR_LIGAND_ID
7CUC9DDI9F UNII
407885 RXNORM
2354 MMSL
5382 MMSL
5383 MMSL
5384 MMSL
d00769 MMSL
001831 NDDF
001832 NDDF
001833 NDDF
005972 NDDF
10595003 SNOMEDCT_US
12177002 SNOMEDCT_US
372900003 SNOMEDCT_US
91435002 SNOMEDCT_US
CHEMBL1201483 ChEMBL_ID
7CUC9DDI9F INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dimetapp HUMAN OTC DRUG LABEL 2 0031-2231 ELIXIR 15 mg ORAL Export only 15 sections
Dimetapp Paediatric HUMAN OTC DRUG LABEL 2 0031-2251 ELIXIR 15 mg ORAL Export only 1 sections
Robitussin CF HUMAN OTC DRUG LABEL 3 0031-8678 LIQUID 30 mg ORAL Export only 15 sections
Theraflu-D Flu Relief Max Strength plus Nasal Decongestant Nighttime HUMAN OTC DRUG LABEL 4 0067-0114 SYRUP 60 mg ORAL OTC Monograph Drug 17 sections
Theraflu-D Flu Relief Max Strength plus Nasal Decongestant HUMAN OTC DRUG LABEL 3 0067-0115 SYRUP 60 mg ORAL OTC Monograph Drug 17 sections
Good Sense Suphedrine12 Hour HUMAN OTC DRUG LABEL 1 0113-0054 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
Good Sense Suphedrine12 Hour HUMAN OTC DRUG LABEL 1 0113-0054 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
good sense all day allergy d HUMAN OTC DRUG LABEL 2 0113-0147 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Zephrex D HUMAN OTC DRUG LABEL 1 0113-0401 CAPSULE, GELATIN COATED 30 mg ORAL OTC Monograph Drug 15 sections
Good Sense Nasal Decongestant HUMAN OTC DRUG LABEL 1 0113-0432 TABLET, FILM COATED 30 mg ORAL OTC Monograph Drug 15 sections
Allergy and Congestion Relief HUMAN OTC DRUG LABEL 2 0113-2007 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
sinus 12 hour HUMAN OTC DRUG LABEL 1 0113-2017 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 15 sections
All Day Allergy D HUMAN OTC DRUG LABEL 2 0113-2147 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
perrigo allergy d HUMAN OTC DRUG LABEL 2 0113-7777 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 15 sections
mucus D HUMAN OTC DRUG LABEL 2 0113-8307 TABLET, MULTILAYER, EXTENDED RELEASE 60 mg ORAL ANDA 14 sections
Mucus D HUMAN OTC DRUG LABEL 2 0113-8911 TABLET, MULTILAYER, EXTENDED RELEASE 120 mg ORAL ANDA 15 sections
allergy d HUMAN OTC DRUG LABEL 2 0113-9004 TABLET, EXTENDED RELEASE 240 mg ORAL ANDA 15 sections
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 3 0121-0933 SOLUTION 30 mg ORAL ANDA 21 sections
Aleve-D Sinus and Headache HUMAN OTC DRUG LABEL 2 0280-6045 TABLET 120 mg ORAL ANDA 17 sections
Aleve-D Sinus and Cold HUMAN OTC DRUG LABEL 2 0280-6090 TABLET 120 mg ORAL ANDA 17 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 2 0363-0044 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
Fexofenadine HCl and Pseudoephedrine HCl HUMAN OTC DRUG LABEL 2 0363-0049 TABLET, EXTENDED RELEASE 240 mg ORAL ANDA 14 sections
Guaifenesin and Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 2 0363-0077 TABLET, EXTENDED RELEASE 60 mg ORAL NDA 16 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride Human OTC Drug Label 2 0363-0094 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 11 sections
Guaifenesin and Pseudoephedrine HCl Human OTC Drug Label 2 0363-0134 TABLET, EXTENDED RELEASE 120 mg ORAL ANDA 14 sections
Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 1 0363-0204 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Cold and Allergy D HUMAN OTC DRUG LABEL 2 0363-0287 TABLET, FILM COATED 60 mg ORAL OTC Monograph Drug 16 sections
Ibuprofen and Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 2 0363-0423 TABLET, COATED 30 mg ORAL ANDA 17 sections
All Day Sinus and Cold D HUMAN OTC DRUG LABEL 2 0363-0650 TABLET, FILM COATED, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Loratadine and Pseudoephedrine HUMAN OTC DRUG LABEL 2 0363-0725 TABLET, FILM COATED, EXTENDED RELEASE 240 mg ORAL ANDA 16 sections