DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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Structure ๐
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
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Download
L1000
FAQ
Scroll
Substructure SMILES Example:
n1cnccc1
proquazone ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
2311
22760-18-5
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
proquazone
anthrex
biarison
nonsteroid anti-inflammatory agent
Molecular weight: 278.36
Formula: C18H18N2O
CLOGP: 3.65
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 32.67
ALOGS: -4.48
ROTB: 2
Drug dosage:
Dose
Unit
Route
0.90
g
O
0.90
g
R
ADMET properties:
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Property
Value
Reference
CL (Clearance)
9.45 mL/min/kg
Lombardo F, Berellini G, Obach RS
MRTD (Maximum Recommended Therapeutic Daily Dose)
71.85 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)
7 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
t_half (Half-life)
1.27 hours
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.52 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.02 %
Lombardo F, Berellini G, Obach RS
Showing 1 to 6 of 6 entries
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
M01AX13
MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Other antiinflammatory and antirheumatic agents, non-steroids
MeSH PA
D000700
Analgesics
MeSH PA
D018712
Analgesics, Non-Narcotic
MeSH PA
D000893
Anti-Inflammatory Agents
MeSH PA
D000894
Anti-Inflammatory Agents, Non-Steroidal
MeSH PA
D018501
Antirheumatic Agents
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D016861
Cyclooxygenase Inhibitors
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D018373
Peripheral Nervous System Agents
Showing 1 to 10 of 11 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
1.74
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Prostaglandin G/H synthase 2
Enzyme
P35354
PGH2_HUMAN
WOMBAT-PK
Prostaglandin G/H synthase 1
Enzyme
P23219
PGH1_HUMAN
WOMBAT-PK
Epidermal growth factor receptor
Kinase
P00533
EGFR_HUMAN
IC50
8.70
CHEMBL
Cyclooxygenase
Enzyme
PGH1_BOVIN
PGH2_BOVIN
IC50
7.15
CHEMBL
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External reference:
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ID
Source
010966
NDDF
31508
PUBCHEM_CID
3176
INN_ID
42VPJ2980S
UNII
C0072247
UMLSCUI
C011385
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135151
CHEBI
CHEMBL268501
ChEMBL_ID
D05638
KEGG_DRUG
DB13649
DRUGBANK_ID
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Pharmaceutical products:
None
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Structure ๐
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proquazone