oxazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 2015 604-75-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxazepam
  • droxacepam
  • durazepam
  • noctazepam
  • tazepam
  • zaxopam
A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
  • Molecular weight: 286.72
  • Formula: C15H11ClN2O2
  • CLOGP: 2.31
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 61.69
  • ALOGS: -3.51
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.05 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.98 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 92.80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.59 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.04 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6.70 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.413 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.875 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 61.235 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 13.964 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 6.890 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 16.100 % High 1
herg hERG pIC50 4.493 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 3.357 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.606 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 7.830 % High 1
kinase-safety-class ACVR2B,EIF2AK3,GRK2,PDK1,PDK2,PDK4 6
kinase-selectivity-class AXL,GRK2,TTK 3
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.652 Moderate 0.77
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 4.150 High 1
mh-clint Mouse hepatocyte intrinsic clearance 20.277 High 1
mppb Mouse plasma protein binding (% unbound) 7.310 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 9.354 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 13.630 % High 1
rat-kpuu-brain Rat brain Kpuu 0.236 % Moderate 0.77
rh-clint Rat hepatocyte intrinsic clearance 34.356 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 69.030 % High 1
rppb Rat plasma protein binding (% unbound) 5.680 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 712.853 uM High 1

Approvals:

DateAgencyCompanyOrphan
June 4, 1965 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1851.12 14.27 1396 47104 286450 90293497
Coma 1522.95 14.27 753 47747 71879 90508068
Depressed level of consciousness 1182.93 14.27 636 47864 72148 90507799
Intentional overdose 1151.49 14.27 682 47818 93152 90486795
Poisoning deliberate 1132.25 14.27 399 48101 16087 90563860
Orthostatic hypotension 1090.36 14.27 504 47996 41323 90538624
Sedation 969.19 14.27 486 48014 47685 90532262
Creatinine renal clearance decreased 951.71 14.27 364 48136 18535 90561412
Sedation complication 946.22 14.27 352 48148 16592 90563355
Cognitive disorder 841.88 14.27 501 47999 68906 90511041
Hypotension 838.77 14.27 948 47552 324449 90255498
Fall 825.02 14.27 1143 47357 480667 90099280
Blood calcium decreased 787.30 14.27 364 48136 29818 90550129
Balance disorder 654.54 14.27 486 48014 96594 90483353
Somnolence 631.68 14.27 663 47837 208421 90371526
Drug abuse 618.15 14.27 440 48060 81907 90498040
Intentional self-injury 604.56 14.27 301 48199 29033 90550914
Suicide attempt 575.41 14.27 407 48093 74992 90504955
Drug interaction 387.31 14.27 598 47902 275855 90304092
Hyponatraemia 380.66 14.27 411 48089 133127 90446820
Constipation 318.74 14.27 552 47948 279843 90300104
Overdose 306.24 14.27 399 48101 157310 90422637
Drug dependence 294.83 14.27 188 48312 29139 90550808
Miosis 280.71 14.27 125 48375 9359 90570588
Electrocardiogram QT prolonged 277.86 14.27 262 48238 72194 90507753
Drug use disorder 276.27 14.27 119 48381 8224 90571723
Drug ineffective 223.95 14.27 248 48252 1384050 89195897
Wrong patient received product 222.81 14.27 80 48420 3397 90576550
Bradycardia 209.39 14.27 241 48259 83606 90496341
Asphyxia 208.23 14.27 93 48407 7010 90572937
Rhabdomyolysis 205.43 14.27 190 48310 51066 90528881
Rash 192.65 14.27 93 48407 796007 89783940
Mobility decreased 190.85 14.27 417 48083 250317 90329630
Poisoning 189.84 14.27 112 48388 15105 90564842
Pneumonia aspiration 188.24 14.27 164 48336 40776 90539171
Abdominal discomfort 185.07 14.27 20 48480 477308 90102639
Hypothermia 179.67 14.27 109 48391 15466 90564481
Systemic lupus erythematosus 178.54 14.27 3 48497 361893 90218054
Prescription form tampering 164.45 14.27 44 48456 683 90579264
Hepatocellular injury 164.26 14.27 131 48369 28827 90551120
Inappropriate antidiuretic hormone secretion 161.95 14.27 111 48389 19394 90560553
Acute kidney injury 158.42 14.27 452 48048 319935 90260012
Joint swelling 157.48 14.27 38 48462 503262 90076685
Drug hypersensitivity 157.35 14.27 29 48471 463580 90116367
Pemphigus 152.45 14.27 5 48495 326859 90253088
Altered state of consciousness 152.43 14.27 130 48370 31402 90548545
Arthropathy 150.83 14.27 12 48488 366230 90213717
Sinusitis 144.81 14.27 10 48490 343078 90236869
Treatment failure 144.09 14.27 4 48496 303924 90276023
Wrong patient 143.69 14.27 41 48459 816 90579131
Serotonin syndrome 143.26 14.27 136 48364 37751 90542196
Swelling 140.50 14.27 27 48473 419031 90160916
Drug intolerance 139.59 14.27 34 48466 447557 90132390
Arthralgia 138.43 14.27 128 48372 778394 89801553
Glossodynia 136.91 14.27 9 48491 321770 90258177
Cholestasis 136.68 14.27 130 48370 36169 90543778
Confusional state 130.22 14.27 478 48022 385727 90194220
Hypersensitivity 129.73 14.27 41 48459 454636 90125311
Hepatic cytolysis 124.61 14.27 115 48385 30801 90549146
Rheumatoid arthritis 122.31 14.27 23 48477 362591 90217356
Peripheral swelling 121.92 14.27 35 48465 413071 90166876
Infusion related reaction 121.74 14.27 36 48464 416744 90163203
Hand deformity 121.19 14.27 10 48490 296352 90283595
Bradypnoea 120.79 14.27 56 48444 4602 90575345
Extrapyramidal disorder 119.57 14.27 86 48414 16217 90563730
Respiratory depression 118.46 14.27 84 48416 15491 90564456
Agitation 118.15 14.27 162 48338 66936 90513011
Lower respiratory tract infection 112.87 14.27 5 48495 250654 90329293
Creatinine renal clearance increased 112.57 14.27 48 48452 3233 90576714
Pericarditis 110.77 14.27 9 48491 270142 90309805
Substance abuse 109.90 14.27 55 48445 5351 90574596
Alopecia 109.02 14.27 65 48435 495006 90084941
Renal function test abnormal 108.68 14.27 60 48440 7131 90572816
Victim of sexual abuse 106.50 14.27 31 48469 664 90579283
Contraindicated product administered 106.48 14.27 21 48479 320118 90259829
Wheezing 106.37 14.27 5 48495 238075 90341872
Hallucination, visual 105.11 14.27 92 48408 23000 90556947
Disorientation 103.74 14.27 123 48377 43991 90535956
Mydriasis 102.86 14.27 76 48424 14936 90565011
Stomatitis 102.66 14.27 13 48487 274685 90305262
Therapeutic product effect decreased 101.66 14.27 14 48486 277557 90302390
Aggression 101.33 14.27 96 48404 26572 90553375
Wound 98.42 14.27 21 48479 302959 90276988
Loss of consciousness 97.32 14.27 225 48275 140013 90439934
Blister 95.45 14.27 12 48488 254986 90324961
Headache 94.25 14.27 201 48299 862545 89717402
Product dose omission issue 93.16 14.27 21 48479 291666 90288281
Hypokalaemia 90.58 14.27 210 48290 130906 90449041
Urinary retention 90.00 14.27 106 48394 37638 90542309
Intentional product misuse 89.48 14.27 167 48333 89437 90490510
Multiple drug therapy 88.50 14.27 52 48448 6957 90572990
Reduced facial expression 86.44 14.27 37 48463 2516 90577431
Hepatic enzyme increased 85.71 14.27 43 48457 360693 90219254
Irritable bowel syndrome 84.78 14.27 7 48493 207441 90372506
Neuroleptic malignant syndrome 82.85 14.27 67 48433 15029 90564918
Nasopharyngitis 82.05 14.27 59 48441 407045 90172902
Oxygen saturation decreased 81.88 14.27 179 48321 107304 90472643
Disturbance in attention 81.80 14.27 113 48387 46996 90532951
Withdrawal syndrome 81.63 14.27 79 48421 22445 90557502
Impaired healing 80.77 14.27 14 48486 234185 90345762
Blood cholesterol increased 79.79 14.27 9 48491 208003 90371944
Hyperthermia 76.89 14.27 55 48445 10280 90569667
Infection 76.26 14.27 50 48450 362044 90217903
Hypoaesthesia 75.31 14.27 37 48463 314173 90265774
Tachycardia 74.44 14.27 219 48281 157454 90422493
Substance use disorder 74.13 14.27 31 48469 1989 90577958
Faecal vomiting 72.66 14.27 24 48476 790 90579157
Fibromyalgia 71.86 14.27 12 48488 206257 90373690
Listless 71.83 14.27 35 48465 3214 90576733
Lactic acidosis 71.57 14.27 110 48390 50353 90529594
Chemical submission 69.69 14.27 21 48479 509 90579438
Muscle rigidity 69.15 14.27 59 48441 14250 90565697
Fatigue 68.43 14.27 352 48148 1153671 89426276
Encephalopathy 68.35 14.27 103 48397 46341 90533606
Bezoar 68.20 14.27 32 48468 2702 90577245
Bladder dilatation 67.47 14.27 24 48476 991 90578956
Victim of chemical submission 66.81 14.27 22 48478 717 90579230
Suicidal ideation 66.79 14.27 132 48368 73723 90506224
Hypotonia 65.45 14.27 52 48448 11374 90568573
On and off phenomenon 64.16 14.27 30 48470 2513 90577434
Ill-defined disorder 63.86 14.27 11 48489 184880 90395067
Injection site pain 63.01 14.27 9 48491 173690 90406257
Mixed liver injury 62.37 14.27 43 48457 7580 90572367
Akathisia 62.24 14.27 50 48450 11109 90568838
Injury 61.42 14.27 15 48485 197334 90382613
Respiratory acidosis 59.93 14.27 43 48457 8076 90571871
Respiratory distress 59.64 14.27 88 48412 38858 90541089
Urticaria 59.56 14.27 48 48452 312686 90267261
Victim of crime 59.41 14.27 21 48479 851 90579096
Benzodiazepine drug level increased 59.03 14.27 15 48485 188 90579759
Type 2 diabetes mellitus 58.47 14.27 18 48482 203226 90376721
Restlessness 58.03 14.27 83 48417 35637 90544310
Hyperkalaemia 57.41 14.27 115 48385 64849 90515098
Asthma 57.28 14.27 29 48471 242131 90337816
Toxic epidermal necrolysis 56.43 14.27 78 48422 32450 90547497
Apathy 56.40 14.27 47 48453 10993 90568954
Hallucination 56.19 14.27 115 48385 65844 90514103
Gastrointestinal disorder 56.00 14.27 34 48466 256653 90323294
Bursitis 55.03 14.27 4 48496 131650 90448297
Haemodynamic instability 53.88 14.27 47 48453 11692 90568255
Agranulocytosis 53.47 14.27 79 48421 34923 90545024
Pruritus 53.47 14.27 133 48367 541392 90038555
Pneumonia 53.20 14.27 170 48330 637889 89942058
Vertigo 52.85 14.27 116 48384 69695 90510252
Eosinophilia 51.89 14.27 70 48430 28463 90551484
Prescription drug used without a prescription 51.51 14.27 28 48472 3227 90576720
Liver injury 51.09 14.27 14 48486 170553 90409394
Cough 50.01 14.27 75 48425 368887 90211060
Musculoskeletal pain 49.56 14.27 15 48485 171236 90408711
Off label use 49.23 14.27 367 48133 1101885 89478062
Osteoarthritis 48.49 14.27 22 48478 195708 90384239
Drug withdrawal convulsions 48.36 14.27 21 48479 1479 90578468
Completed suicide 48.28 14.27 179 48321 144879 90435068
Cardiogenic shock 47.53 14.27 62 48438 24406 90555541
Therapy non-responder 47.50 14.27 8 48492 136696 90443251
Pain in extremity 47.36 14.27 107 48393 450422 90129525
Cardio-respiratory arrest 45.64 14.27 103 48397 63037 90516910
Tremor 43.66 14.27 180 48320 152993 90426954
Musculoskeletal stiffness 43.43 14.27 57 48443 296475 90283472
Acetonaemia 42.99 14.27 13 48487 319 90579628
Sudden death 42.83 14.27 40 48460 10869 90569078
Behaviour disorder 42.35 14.27 28 48472 4607 90575340
Chest pain 42.32 14.27 66 48434 319579 90260368
Pyrexia 42.15 14.27 196 48304 660289 89919658
Accidental overdose 42.02 14.27 63 48437 28210 90551737
Hypertonia 41.99 14.27 29 48471 5126 90574821
Obesity 41.90 14.27 4 48496 105503 90474444
Abnormal behaviour 41.89 14.27 56 48444 22572 90557375
Potentiating drug interaction 41.82 14.27 30 48470 5632 90574315
Night sweats 41.63 14.27 9 48491 128757 90451190
Wrong rate 41.52 14.27 11 48489 164 90579783
Upper respiratory tract infection 41.42 14.27 9 48491 128309 90451638
Psychomotor skills impaired 40.77 14.27 23 48477 2849 90577098
Rash maculo-papular 39.24 14.27 75 48425 40858 90539089
Sinus tachycardia 38.81 14.27 61 48439 28452 90551495
Back pain 38.73 14.27 69 48431 317106 90262841
Freezing phenomenon 38.50 14.27 19 48481 1793 90578154
Foreign body 38.21 14.27 21 48479 2473 90577474
Foetal growth restriction 38.00 14.27 35 48465 9345 90570602
Housebound 37.81 14.27 11 48489 235 90579712
Psoriasis 37.55 14.27 16 48484 147738 90432209
Arterial intramural haematoma 36.75 14.27 10 48490 166 90579781
Patient uncooperative 36.25 14.27 11 48489 273 90579674
Vasoplegia syndrome 35.85 14.27 21 48479 2793 90577154
Gait inability 35.43 14.27 17 48483 146439 90433508
Migraine 35.26 14.27 30 48470 190362 90389585
Sciatica 35.07 14.27 6 48494 101376 90478571
Product use issue 34.94 14.27 78 48422 329841 90250106
Drug reaction with eosinophilia and systemic symptoms 34.60 14.27 73 48427 42685 90537262
Dyspepsia 34.58 14.27 33 48467 198127 90381820
Sinus bradycardia 34.56 14.27 44 48456 16908 90563039
Adverse drug reaction 34.16 14.27 10 48490 116691 90463256
Antipsychotic drug level above therapeutic 33.91 14.27 16 48484 1368 90578579
Road traffic accident 33.83 14.27 8 48492 107618 90472329
Peripheral venous disease 33.81 14.27 3 48497 83918 90496029
Cardiac failure congestive 33.79 14.27 6 48494 98688 90481259
Hypereosinophilic syndrome 33.69 14.27 11 48489 349 90579598
Cholinergic syndrome 33.56 14.27 13 48487 683 90579264
COVID-19 33.28 14.27 25 48475 168818 90411129
Red blood cell sedimentation rate increased 33.15 14.27 3 48497 82592 90497355
Cholestatic liver injury 32.44 14.27 22 48478 3775 90576172
Hypoventilation 32.27 14.27 25 48475 5271 90574676
Respiratory alkalosis 31.92 14.27 21 48479 3427 90576520
Pulmonary fibrosis 31.86 14.27 9 48491 107494 90472453
Hypocoagulable state 31.71 14.27 16 48484 1583 90578364
Shock 31.71 14.27 56 48444 28722 90551225
Disease progression 31.11 14.27 23 48477 156592 90423355
Adverse event 31.00 14.27 12 48488 117406 90462541
Drug level increased 30.56 14.27 54 48446 27708 90552239
Blood thyroid stimulating hormone normal 30.47 14.27 8 48492 115 90579832
Abdominal pain upper 30.28 14.27 85 48415 332589 90247358
Drug level above therapeutic 30.23 14.27 25 48475 5784 90574163
Psychomotor retardation 30.04 14.27 23 48477 4766 90575181
Hepatic infiltration eosinophilic 29.97 14.27 6 48494 22 90579925
Wrong product administered 29.89 14.27 28 48472 7637 90572310
Metabolic acidosis 29.83 14.27 81 48419 55595 90524352
Stoma site erythema 29.76 14.27 15 48485 1481 90578466
Therapeutic product effect incomplete 29.70 14.27 36 48464 193860 90386087
Weight increased 29.68 14.27 119 48381 417808 90162139
Muscle spasms 29.67 14.27 56 48444 251827 90328120
Small fibre neuropathy 29.59 14.27 12 48488 712 90579235
Wound infection 29.57 14.27 10 48490 106392 90473555
Parkinsonism 29.46 14.27 37 48463 14028 90565919
Intentional product use issue 29.44 14.27 44 48456 216848 90363099
Hypoventilation neonatal 29.36 14.27 6 48494 25 90579922
White blood cell count decreased 28.95 14.27 28 48472 167081 90412866
Major depression 28.72 14.27 31 48469 10004 90569943
Pelvic fracture 28.68 14.27 38 48462 15181 90564766
Contusion 28.59 14.27 57 48443 251159 90328788
Analgesic drug level above therapeutic 28.09 14.27 8 48492 158 90579789
Injection site erythema 27.82 14.27 9 48491 98493 90481454
Condition aggravated 27.58 14.27 196 48304 595349 89984598
Antidepressant drug level above therapeutic 26.68 14.27 10 48490 480 90579467
Head discomfort 26.59 14.27 38 48462 16295 90563652
Haematoma 26.34 14.27 62 48438 38986 90540961
Dry mouth 26.31 14.27 36 48464 184023 90395924
Hyperkinesia 26.25 14.27 15 48485 1904 90578043
Fibroma 26.14 14.27 12 48488 964 90578983
Neuropathy peripheral 26.08 14.27 21 48479 136949 90442998
Prothrombin time ratio decreased 25.92 14.27 12 48488 983 90578964
Salivary hypersecretion 25.87 14.27 28 48472 9064 90570883
Stoma site discharge 25.75 14.27 15 48485 1974 90577973
Dementia 25.73 14.27 46 48454 23815 90556132
Therapeutic response decreased 25.70 14.27 8 48492 89721 90490226
Neurosensory hypoacusis 25.62 14.27 8 48492 219 90579728
Dehydration 25.58 14.27 185 48315 194262 90385685
Inflammation 25.45 14.27 35 48465 178557 90401390
Neurological examination abnormal 25.27 14.27 9 48491 373 90579574
Hallucination, synaesthetic 25.22 14.27 6 48494 56 90579891
Liver disorder 25.15 14.27 17 48483 121252 90458695
Injection site reaction 24.99 14.27 9 48491 92071 90487876
Blood testosterone increased 24.65 14.27 8 48492 249 90579698
Live birth 24.63 14.27 6 48494 79101 90500846
Galactorrhoea 24.09 14.27 20 48480 4652 90575295
Tension 23.79 14.27 18 48482 3664 90576283
Discomfort 23.57 14.27 72 48428 274263 90305684
Apnoea 23.37 14.27 27 48473 9387 90570560
Poor quality sleep 23.37 14.27 45 48455 24648 90555299
Diarrhoea infectious 23.32 14.27 12 48488 1237 90578710
Foetal alcohol syndrome 23.25 14.27 5 48495 28 90579919
Gamma-glutamyltransferase increased 23.19 14.27 58 48442 37894 90542053
Oedema 23.17 14.27 45 48455 200250 90379697
Pre-eclampsia 23.04 14.27 29 48471 11019 90568928
Diarrhoea 23.02 14.27 359 48141 938831 89641116
Taste disorder 22.76 14.27 3 48497 61543 90518404
Dyskinesia 22.49 14.27 56 48444 36478 90543469
Status epilepticus 22.46 14.27 38 48462 18836 90561111
Drug withdrawal syndrome 22.04 14.27 48 48452 28675 90551272
Generalised tonic-clonic seizure 22.02 14.27 54 48446 34849 90545098
Injection site swelling 21.93 14.27 3 48497 59836 90520111
Foot deformity 21.84 14.27 3 48497 59648 90520299
Rhinorrhoea 21.75 14.27 10 48490 88306 90491641
Hospitalisation 21.57 14.27 22 48478 128078 90451869
Antisocial behaviour 21.44 14.27 9 48491 583 90579364
Gastrooesophageal reflux disease 21.37 14.27 35 48465 166302 90413645
Antipsychotic drug level increased 21.22 14.27 17 48483 3762 90576185
Prescribed overdose 21.18 14.27 13 48487 97612 90482335
Nightmare 21.06 14.27 40 48460 21685 90558262
Hypersexuality 20.95 14.27 9 48491 617 90579330
Delusion 20.79 14.27 31 48469 13809 90566138
Myoclonus 20.73 14.27 37 48463 19131 90560816
Electrocardiogram QRS complex abnormal 20.54 14.27 7 48493 254 90579693
Immobile 20.52 14.27 21 48479 6377 90573570
Dysarthria 20.48 14.27 70 48430 54412 90525535
Platelet count decreased 20.38 14.27 26 48474 136943 90443004
Needle track marks 20.13 14.27 4 48496 14 90579933
Herpes zoster 19.98 14.27 13 48487 94631 90485316
Cardioactive drug level above therapeutic 19.97 14.27 6 48494 144 90579803
Colitis ulcerative 19.91 14.27 4 48496 60262 90519685
Neck pain 19.85 14.27 19 48481 113944 90466003
Concussion 19.84 14.27 27 48473 11064 90568883
Mucosa vesicle 19.81 14.27 6 48494 148 90579799
Hypercapnia 19.77 14.27 21 48479 6656 90573291
Hepatic failure 19.51 14.27 56 48444 39672 90540275
Bradykinesia 19.48 14.27 21 48479 6767 90573180
Cerebral haematoma 19.34 14.27 17 48483 4272 90575675
Posture abnormal 19.19 14.27 14 48486 2697 90577250
Medulloblastoma 19.17 14.27 5 48495 70 90579877
Anal paraesthesia 18.98 14.27 4 48496 20 90579927
Haematoma muscle 18.93 14.27 12 48488 1838 90578109
Myelosuppression 18.91 14.27 3 48497 53588 90526359
Hypopnoea 18.86 14.27 17 48483 4414 90575533
Cryoglobulinaemia 18.73 14.27 9 48491 801 90579146
Retrograde amnesia 18.66 14.27 8 48492 546 90579401
Alcohol poisoning 18.57 14.27 12 48488 1900 90578047
Haemorrhagic stroke 18.47 14.27 20 48480 6476 90573471
Delirium 18.45 14.27 107 48393 104252 90475695
Substance abuser 18.36 14.27 6 48494 191 90579756
Brain death 18.25 14.27 16 48484 4005 90575942
Genital paraesthesia 18.22 14.27 4 48496 25 90579922
Atrioventricular block 18.16 14.27 23 48477 8792 90571155
Electrocardiogram QRS complex prolonged 18.12 14.27 21 48479 7327 90572620
Nausea 17.95 14.27 455 48045 1109861 89470086
Sepsis 17.83 14.27 44 48456 179770 90400177
Flushing 17.56 14.27 13 48487 88478 90491469
22q11.2 deletion syndrome 17.52 14.27 3 48497 3 90579944
Hypoxia 17.50 14.27 81 48419 72318 90507629
Frontotemporal dementia 17.44 14.27 7 48493 404 90579543
Oesophageal achalasia 17.22 14.27 8 48492 660 90579287
Malaise 17.16 14.27 216 48284 585770 89994177
Pleurothotonus 17.10 14.27 10 48490 1325 90578622
Persecutory delusion 17.10 14.27 14 48486 3194 90576753
Hypovolaemic shock 17.03 14.27 20 48480 7074 90572873
Megacolon 16.97 14.27 12 48488 2202 90577745
Nasal congestion 16.89 14.27 12 48488 83402 90496545
Trichoglossia 16.64 14.27 7 48493 456 90579491
Arthritis 16.54 14.27 41 48459 167274 90412673
Cataract 16.49 14.27 9 48491 72083 90507864
Lipohypertrophy 16.45 14.27 8 48492 731 90579216
Frequent bowel movements 16.44 14.27 5 48495 56930 90523017
Hypercapnic coma 16.44 14.27 6 48494 267 90579680
Maternal exposure during pregnancy 16.39 14.27 119 48381 359944 90220003
Shock haemorrhagic 16.39 14.27 26 48474 12219 90567728
Hypercholesterolaemia 16.23 14.27 18 48482 100874 90479073
Multiple organ dysfunction syndrome 16.18 14.27 76 48424 68260 90511687
Dry skin 16.15 14.27 14 48486 88059 90491888
Joint stiffness 16.10 14.27 11 48489 78031 90501916
Seizure 16.09 14.27 138 48362 152491 90427456
Enanthema 15.99 14.27 7 48493 503 90579444
Influenza like illness 15.80 14.27 12 48488 80599 90499348
Product administration error 15.74 14.27 40 48460 26383 90553564
Chondropathy 15.61 14.27 12 48488 2500 90577447
Subileus 15.55 14.27 14 48486 3630 90576317
Palatal swelling 15.55 14.27 5 48495 151 90579796
Ear infection 15.54 14.27 9 48491 69766 90510181
Asthenia 15.53 14.27 197 48303 533554 90046393
Genital neoplasm malignant female 15.48 14.27 5 48495 153 90579794
Stoma site reaction 15.42 14.27 6 48494 319 90579628
Incoherent 15.35 14.27 16 48484 4961 90574986
Aspiration 15.34 14.27 29 48471 15664 90564283
Immature respiratory system 15.33 14.27 4 48496 56 90579891
Pregnancy 15.31 14.27 7 48493 62040 90517907
Pneumothorax traumatic 15.21 14.27 5 48495 162 90579785
Action tremor 15.16 14.27 6 48494 334 90579613
Dyspnoea 15.03 14.27 358 48142 880597 89699350
Oropharyngeal pain 15.02 14.27 24 48476 115163 90464784
Gastric cancer 14.94 14.27 16 48484 5120 90574827
Paraesthesia 14.92 14.27 76 48424 250250 90329697
Hyperammonaemic encephalopathy 14.85 14.27 12 48488 2687 90577260
Anterograde amnesia 14.80 14.27 7 48493 602 90579345
Nephrolithiasis 14.75 14.27 4 48496 49081 90530866
Pemphigoid 14.70 14.27 21 48479 9005 90570942
Mutism 14.52 14.27 10 48490 1759 90578188
Irritability 14.45 14.27 47 48453 35615 90544332
Cerebral haemorrhage 14.45 14.27 46 48454 34476 90545471
Adenocarcinoma gastric 14.37 14.27 7 48493 642 90579305

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1338.14 15.72 901 32964 103870 42483600
Toxicity to various agents 1337.82 15.72 1240 32625 227896 42359574
Coma 979.36 15.72 579 33286 52975 42534495
Drug use disorder 633.71 15.72 256 33609 10077 42577393
Poisoning deliberate 590.39 15.72 242 33623 9892 42577578
Drug dependence 534.79 15.72 316 33549 28778 42558692
Miosis 512.10 15.72 238 33627 13208 42574262
Asphyxia 495.79 15.72 202 33663 8124 42579346
Poisoning 450.01 15.72 224 33641 14475 42572995
Substance use disorder 396.38 15.72 152 33713 5193 42582277
Substance abuse 362.08 15.72 165 33700 8740 42578730
Aggression 343.77 15.72 283 33582 43880 42543590
Somnolence 323.42 15.72 474 33391 140631 42446839
Overdose 277.10 15.72 378 33487 104886 42482584
Altered state of consciousness 264.98 15.72 205 33660 29054 42558416
Depressed level of consciousness 251.48 15.72 246 33619 47724 42539746
Intentional overdose 233.38 15.72 244 33621 51212 42536258
Suicide attempt 192.04 15.72 209 33656 45891 42541579
Logorrhoea 177.00 15.72 71 33794 2736 42584734
Bradypnoea 158.63 15.72 75 33790 4318 42583152
Agitation 157.10 15.72 223 33642 64091 42523379
Restlessness 151.33 15.72 149 33716 29100 42558370
Abnormal behaviour 150.53 15.72 142 33723 26309 42561161
Bradykinesia 132.16 15.72 71 33794 5365 42582105
Mydriasis 124.75 15.72 81 33784 8689 42578781
Respiratory depression 120.38 15.72 108 33757 18760 42568710
Drug interaction 116.20 15.72 469 33396 266530 42320940
Disturbance in attention 111.61 15.72 128 33737 29738 42557732
Hepatocellular injury 108.53 15.72 113 33752 23565 42563905
Confusional state 107.82 15.72 335 33530 167262 42420208
Pneumonia aspiration 106.87 15.72 163 33702 49915 42537555
Dysarthria 101.56 15.72 141 33724 39666 42547804
Dystonic tremor 100.42 15.72 28 33837 335 42587135
Visceral congestion 100.38 15.72 35 33830 906 42586564
Intentional product misuse 99.09 15.72 177 33688 61723 42525747
Bradyphrenia 98.76 15.72 58 33807 5204 42582266
Intentional self-injury 91.06 15.72 84 33781 15118 42572352
Brain oedema 87.83 15.72 85 33780 16242 42571228
Drug ineffective 87.49 15.72 237 33628 629960 41957510
Pulmonary oedema 83.55 15.72 151 33714 53121 42534349
Alcohol abuse 76.96 15.72 45 33820 4004 42583466
Product dose omission issue 76.30 15.72 15 33850 154350 42433120
Hepatic cytolysis 75.93 15.72 100 33765 26744 42560726
Disorientation 74.18 15.72 116 33749 36273 42551197
Bladder dilatation 74.02 15.72 33 33832 1657 42585813
Cardio-respiratory arrest 72.14 15.72 150 33715 58486 42528984
Off label use 70.39 15.72 266 33599 638069 41949401
Platelet count decreased 67.37 15.72 14 33851 138567 42448903
Bezoar 65.94 15.72 28 33837 1248 42586222
Wrong patient 65.22 15.72 23 33842 616 42586854
Withdrawal syndrome 63.23 15.72 68 33797 14707 42572763
Hypothermia 61.46 15.72 62 33803 12453 42575017
Drug screen positive 60.83 15.72 39 33826 4092 42583378
Respiratory distress 59.86 15.72 114 33751 41706 42545764
Hyper IgE syndrome 59.80 15.72 16 33849 162 42587308
Arthralgia 59.06 15.72 46 33819 205192 42382278
Behaviour disorder 58.58 15.72 47 33818 7007 42580463
Wrong patient received product 58.21 15.72 36 33829 3547 42583923
Fatigue 57.90 15.72 167 33698 435474 42151996
Tardive dyskinesia 57.21 15.72 46 33819 6878 42580592
Hepatitis acute 56.50 15.72 51 33814 8924 42578546
Hyperthermia 55.80 15.72 59 33806 12515 42574955
Hamartoma 55.21 15.72 12 33853 44 42587426
Housebound 55.14 15.72 16 33849 223 42587247
Hallucination, visual 52.90 15.72 74 33791 20946 42566524
Psychotic behaviour 52.86 15.72 22 33843 932 42586538
Accidental death 52.70 15.72 32 33833 3051 42584419
Pain 52.21 15.72 71 33794 244777 42342693
Rash 51.66 15.72 88 33777 276866 42310604
Nausea 50.61 15.72 155 33710 396644 42190826
Sepsis 49.76 15.72 51 33814 199283 42388187
Mania 49.51 15.72 51 33814 10496 42576974
Cholestasis 48.75 15.72 91 33774 32788 42554682
Respiratory acidosis 47.98 15.72 40 33825 6291 42581179
Electrocardiogram QT prolonged 46.96 15.72 112 33753 47833 42539637
Tachycardia 46.53 15.72 181 33684 100906 42486564
Drug hypersensitivity 46.36 15.72 11 33854 99378 42488092
Cardiac failure congestive 45.15 15.72 7 33858 85595 42501875
Pneumonia 45.01 15.72 178 33687 421971 42165499
COVID-19 44.82 15.72 18 33847 115930 42471540
Sedation 44.75 15.72 84 33781 30391 42557079
Rhabdomyolysis 44.65 15.72 150 33715 77869 42509601
Disease progression 44.16 15.72 30 33835 143626 42443844
Peripheral swelling 44.10 15.72 9 33856 90261 42497209
Homicide 43.73 15.72 19 33846 896 42586574
White blood cell count decreased 42.90 15.72 17 33848 110379 42477091
Pain in extremity 41.74 15.72 35 33830 150569 42436901
Suicidal ideation 41.36 15.72 107 33758 48054 42539416
Neuropathy peripheral 40.71 15.72 15 33850 101838 42485632
Oesophageal obstruction 40.64 15.72 16 33849 586 42586884
Back pain 40.47 15.72 32 33833 141744 42445726
Pyrexia 40.19 15.72 169 33696 393873 42193597
Maternal exposure during pregnancy 38.79 15.72 37 33828 6941 42580529
Cough 38.59 15.72 51 33814 178052 42409418
Accidental overdose 37.82 15.72 75 33790 28255 42559215
Diarrhoea 37.57 15.72 214 33651 460635 42126835
Thrombosis 37.53 15.72 5 33860 68506 42518964
Foetal growth restriction 37.21 15.72 32 33833 5251 42582219
Reduced facial expression 37.19 15.72 20 33845 1513 42585957
Drug level increased 36.96 15.72 71 33794 26129 42561341
Neonatal respiratory distress 36.45 15.72 17 33848 948 42586522
Melanoderma 36.16 15.72 11 33854 182 42587288
Pruritus 36.06 15.72 59 33806 188712 42398758
Arteriosclerosis coronary artery 35.93 15.72 58 33807 18619 42568851
Potentiating drug interaction 35.39 15.72 34 33831 6434 42581036
Victim of crime 35.10 15.72 14 33851 531 42586939
Psychotic disorder 35.06 15.72 74 33791 29134 42558336
Tongue biting 34.52 15.72 17 33848 1070 42586400
Myoclonus 34.21 15.72 54 33811 17011 42570459
Acute kidney injury 33.64 15.72 442 33423 366895 42220575
Pulmonary congestion 33.24 15.72 51 33814 15679 42571791
Hospitalisation 33.16 15.72 9 33856 74321 42513149
Fall 32.33 15.72 306 33559 234214 42353256
Accidental poisoning 31.70 15.72 17 33848 1279 42586191
Extrapyramidal disorder 31.62 15.72 51 33814 16361 42571109
Headache 31.52 15.72 92 33773 239277 42348193
Toxic epidermal necrolysis 31.21 15.72 67 33798 26683 42560787
Loss of consciousness 30.71 15.72 150 33715 92204 42495266
Neuroleptic malignant syndrome 30.06 15.72 58 33807 21414 42566056
Bradycardia 29.99 15.72 141 33724 85343 42502127
Neutrophil count decreased 29.60 15.72 7 33858 63408 42524062
Urticaria 29.42 15.72 11 33854 74025 42513445
Hepatic fibrosis 29.32 15.72 27 33838 4845 42582625
Dyskinesia 28.94 15.72 63 33802 25327 42562143
Troponin T increased 28.51 15.72 21 33844 2759 42584711
Cognitive disorder 28.39 15.72 75 33790 34097 42553373
Vascular purpura 28.20 15.72 19 33846 2167 42585303
Status epilepticus 28.11 15.72 47 33818 15531 42571939
Traumatic haemothorax 27.94 15.72 11 33854 403 42587067
Hypotension 27.87 15.72 320 33545 257311 42330159
Oesophageal haemorrhage 27.63 15.72 16 33849 1398 42586072
Oxygen saturation decreased 27.48 15.72 113 33752 64574 42522896
Muscle contracture 27.41 15.72 16 33849 1419 42586051
Thinking abnormal 27.25 15.72 31 33834 7130 42580340
Stomatitis 26.80 15.72 4 33861 50325 42537145
Lactic acidosis 26.75 15.72 88 33777 45173 42542297
Therapy non-responder 26.73 15.72 5 33860 53354 42534116
Cellulitis 26.47 15.72 8 33857 61577 42525893
Hyponatraemia 26.37 15.72 154 33711 101308 42486162
Eosinophilic myocarditis 25.41 15.72 15 33850 1358 42586112
Cholestatic liver injury 25.18 15.72 22 33843 3687 42583783
Chest pain 24.46 15.72 46 33819 139484 42447986
Drug ineffective for unapproved indication 23.83 15.72 4 33861 46159 42541311
Treatment failure 23.74 15.72 10 33855 62614 42524856
Asthma 23.54 15.72 10 33855 62304 42525166
Rheumatoid nodule 22.86 15.72 19 33846 2976 42584494
Patient uncooperative 22.83 15.72 11 33854 660 42586810
Dissociative disorder 22.82 15.72 11 33854 661 42586809
Vasoplegia syndrome 22.70 15.72 18 33847 2637 42584833
Joint swelling 22.55 15.72 13 33852 68009 42519461
Delirium 22.50 15.72 92 33773 52427 42535043
Dystonia 22.29 15.72 38 33827 12752 42574718
Loss of personal independence in daily activities 22.28 15.72 6 33859 49810 42537660
Food aversion 22.26 15.72 10 33855 511 42586959
Visceral oedema 22.23 15.72 6 33859 63 42587407
Vestibular disorder 22.15 15.72 13 33852 1164 42586306
Encephalocele 22.10 15.72 5 33860 23 42587447
Hypotonia neonatal 21.82 15.72 14 33851 1470 42586000
Pleurothotonus 21.81 15.72 13 33852 1198 42586272
Mixed liver injury 21.66 15.72 22 33843 4452 42583018
Drug diversion 21.52 15.72 12 33853 975 42586495
Nasopharyngitis 21.49 15.72 21 33844 83975 42503495
Hypoosmolar state 21.36 15.72 7 33858 149 42587321
Urticaria chronic 21.27 15.72 7 33858 151 42587319
Muscle rigidity 21.24 15.72 36 33829 12023 42575447
Coordination abnormal 21.24 15.72 29 33836 8021 42579449
Atonic seizures 21.07 15.72 9 33856 407 42587063
Psychomotor hyperactivity 21.03 15.72 34 33831 10924 42576546
Urinary tract infection 20.90 15.72 29 33836 99255 42488215
Hypoventilation 20.83 15.72 20 33845 3782 42583688
Consciousness fluctuating 20.82 15.72 13 33852 1302 42586168
Plasma cell myeloma 20.77 15.72 6 33859 47572 42539898
Hyperdynamic left ventricle 20.77 15.72 8 33857 276 42587194
Sinusitis 20.58 15.72 6 33859 47286 42540184
Swelling 20.42 15.72 9 33856 54876 42532594
Anterograde amnesia 20.35 15.72 8 33857 292 42587178
Atrial fibrillation 20.34 15.72 51 33814 139542 42447928
Lower respiratory tract infection 20.34 15.72 4 33861 41202 42546268
Chills 20.28 15.72 27 33838 94039 42493431
Blood pressure increased 20.26 15.72 31 33834 101897 42485573
Emotional disorder 20.18 15.72 25 33840 6289 42581181
Antasthmatic drug level 19.74 15.72 5 33860 40 42587430
Fluid replacement 19.68 15.72 8 33857 319 42587151
Oedema peripheral 19.61 15.72 50 33815 136026 42451444
Mutism 19.56 15.72 13 33852 1449 42586021
Blood creatinine increased 19.51 15.72 36 33829 109967 42477503
Analgesic drug level 19.42 15.72 5 33860 43 42587427
Disturbance in social behaviour 19.35 15.72 14 33851 1789 42585681
Hypomania 19.33 15.72 16 33849 2492 42584978
Victim of homicide 19.26 15.72 7 33858 205 42587265
Otospondylomegaepiphyseal dysplasia 19.15 15.72 6 33859 110 42587360
Rash maculo-papular 18.76 15.72 69 33796 37434 42550036
Pancreatitis acute 18.72 15.72 64 33801 33500 42553970
Completed suicide 18.69 15.72 136 33729 96329 42491141
Agranulocytosis 18.52 15.72 60 33805 30552 42556918
Coagulation factor VII level decreased 18.43 15.72 6 33859 125 42587345
Cardiac pacemaker evaluation 18.39 15.72 6 33859 126 42587344
Hypercapnia 18.39 15.72 22 33843 5339 42582131
Fear 18.35 15.72 32 33833 10933 42576537
Dyspnoea 18.29 15.72 245 33620 442376 42145094
Inappropriate schedule of product administration 18.27 15.72 30 33835 95872 42491598
Generalised onset non-motor seizure 18.13 15.72 4 33861 16 42587454
Persecutory delusion 18.13 15.72 18 33847 3546 42583924
Haemoglobin decreased 18.08 15.72 50 33815 132421 42455049
Spinal cord injury thoracic 18.08 15.72 6 33859 133 42587337
Haematocrit decreased 18.07 15.72 3 33862 34905 42552565
Acute myocardial infarction 18.05 15.72 12 33853 58153 42529317
Acquired haemophilia 17.96 15.72 13 33852 1662 42585808
Aspiration 17.74 15.72 42 33823 17844 42569626
Hepatorenal syndrome 17.53 15.72 16 33849 2838 42584632
Colitis ischaemic 17.53 15.72 25 33840 7201 42580269
Blood glucose increased 17.09 15.72 20 33845 73679 42513791
Pleural effusion 17.05 15.72 32 33833 97134 42490336
Sensorimotor disorder 17.02 15.72 8 33857 454 42587016
Infusion related reaction 16.99 15.72 14 33851 60792 42526678
Vocal cord paralysis 16.91 15.72 11 33854 1183 42586287
Anaemia 16.90 15.72 142 33723 280136 42307334
Stress 16.85 15.72 7 33858 44205 42543265
Cardiac hypertrophy 16.85 15.72 11 33854 1190 42586280
N-terminal prohormone brain natriuretic peptide increased 16.75 15.72 17 33848 3436 42584034
Encephalopathy 16.60 15.72 71 33794 41262 42546208
Injection site pain 16.53 15.72 13 33852 57785 42529685
Red blood cell count decreased 16.52 15.72 3 33862 32712 42554758
Gastrointestinal haemorrhage 16.44 15.72 33 33832 97693 42489777
Drug intolerance 16.42 15.72 24 33841 80400 42507070
Regurgitation 16.26 15.72 13 33852 1927 42585543
Screaming 16.22 15.72 13 33852 1934 42585536
Wheezing 16.08 15.72 12 33853 54769 42532701
Apathy 16.02 15.72 26 33839 8380 42579090
Obstructive pancreatitis 15.98 15.72 9 33856 746 42586724
Gallbladder injury 15.95 15.72 6 33859 194 42587276

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 3028.87 13.64 2544 72920 478011 110035824
Coma 2458.39 13.64 1318 74146 116551 110397284
Drug abuse 1833.15 13.64 1265 74199 176146 110337689
Poisoning deliberate 1656.45 13.64 637 74827 25694 110488141
Depressed level of consciousness 1266.40 13.64 846 74618 111432 110402403
Intentional overdose 881.55 13.64 727 74737 131774 110382061
Drug use disorder 877.85 13.64 363 75101 17711 110496124
Somnolence 865.26 13.64 1039 74425 296410 110217425
Sedation 845.70 13.64 550 74914 69133 110444702
Sedation complication 841.65 13.64 362 75102 19493 110494342
Creatinine renal clearance decreased 841.00 13.64 372 75092 21443 110492392
Orthostatic hypotension 838.75 13.64 537 74927 65712 110448123
Miosis 796.69 13.64 359 75105 21624 110492211
Cognitive disorder 748.12 13.64 557 74907 86954 110426881
Drug dependence 730.36 13.64 444 75020 49576 110464259
Fall 700.80 13.64 1375 74089 602107 109911728
Asphyxia 668.37 13.64 279 75185 13936 110499899
Blood calcium decreased 660.35 13.64 370 75094 35475 110478360
Hypotension 660.00 13.64 1236 74228 522613 109991222
Poisoning 629.20 13.64 334 75130 28771 110485064
Suicide attempt 592.58 13.64 521 74943 102873 110410962
Overdose 544.93 13.64 732 74732 233062 110280773
Balance disorder 524.04 13.64 513 74951 116047 110397788
Substance use disorder 485.54 13.64 184 75280 7106 110506729
Substance abuse 452.97 13.64 204 75260 12259 110501576
Aggression 448.86 13.64 351 75113 58859 110454976
Drug interaction 424.59 13.64 1005 74459 499178 110014657
Intentional self-injury 416.43 13.64 280 75184 37149 110476686
Altered state of consciousness 403.39 13.64 326 75138 57300 110456535
Electrocardiogram QT prolonged 297.06 13.64 369 75095 108591 110405244
Hyponatraemia 292.45 13.64 529 74935 217124 110296711
Pneumonia aspiration 284.69 13.64 313 75151 80920 110432915
Wrong patient received product 257.73 13.64 114 75350 6560 110507275
Bradypnoea 256.53 13.64 123 75341 8526 110505309
Hepatocellular injury 250.31 13.64 235 75229 50407 110463428
Respiratory depression 247.42 13.64 192 75272 31809 110482026
Drug ineffective 234.86 13.64 426 75038 1520114 108993721
Agitation 231.58 13.64 333 75131 112718 110401117
Rhabdomyolysis 224.08 13.64 339 75125 120062 110393773
Hypothermia 212.51 13.64 162 75302 26140 110487695
Confusional state 212.01 13.64 752 74712 467928 110045907
Rash 199.52 13.64 161 75303 820803 109693032
Arthralgia 198.21 13.64 146 75318 779486 109734349
Wrong patient 197.64 13.64 63 75401 1436 110512399
Drug hypersensitivity 196.87 13.64 36 75428 454054 110059781
Mydriasis 195.78 13.64 144 75320 22013 110491822
Bradycardia 189.98 13.64 363 75101 155154 110358681
Disturbance in attention 188.55 13.64 222 75242 61773 110452062
Hepatic cytolysis 187.45 13.64 209 75255 54844 110458991
Abnormal behaviour 186.88 13.64 178 75286 38861 110474974
Constipation 186.30 13.64 602 74862 357184 110156651
Intentional product misuse 184.73 13.64 328 75136 132576 110381259
Joint swelling 175.79 13.64 43 75421 442802 110071033
Restlessness 170.32 13.64 201 75263 56058 110457777
Cholestasis 170.18 13.64 215 75249 64303 110449532
Acute kidney injury 170.01 13.64 869 74595 634561 109879274
Mobility decreased 164.14 13.64 442 75022 236980 110276855
Disorientation 160.81 13.64 219 75245 70452 110443383
Logorrhoea 157.74 13.64 74 75390 4883 110508952
Abdominal discomfort 156.78 13.64 38 75426 393820 110120015
Peripheral swelling 155.04 13.64 42 75422 403992 110109843
Sinusitis 154 13.64 13 75451 296675 110217160
Synovitis 150.94 13.64 9 75455 274083 110239752
Systemic lupus erythematosus 147.55 13.64 6 75458 254332 110259503
Swelling 145.45 13.64 31 75433 351010 110162825
Treatment failure 144.29 13.64 12 75452 277222 110236613
Arthropathy 142.85 13.64 15 75449 287507 110226328
Drug intolerance 142.07 13.64 50 75414 406462 110107373
Lower respiratory tract infection 140.14 13.64 6 75458 243100 110270735
Infusion related reaction 140.02 13.64 43 75421 381119 110132716
Headache 136.76 13.64 246 75218 882131 109631704
Bladder dilatation 135.58 13.64 54 75410 2385 110511450
Inappropriate antidiuretic hormone secretion 131.86 13.64 138 75326 33713 110480122
Hyperthermia 131.43 13.64 112 75352 21160 110492675
Hallucination, visual 130.79 13.64 148 75316 39457 110474378
Product dose omission issue 130.10 13.64 30 75434 321752 110192083
Stomatitis 129.48 13.64 16 75448 270226 110243609
Extrapyramidal disorder 127.60 13.64 126 75338 28741 110485094
Serotonin syndrome 126.61 13.64 178 75286 58975 110454860
Rheumatoid arthritis 125.04 13.64 26 75438 299587 110214248
Pemphigus 124.67 13.64 5 75459 214565 110299270
Hypersensitivity 124.50 13.64 60 75404 403938 110109897
Pericarditis 124.36 13.64 6 75458 219108 110294727
Bezoar 124.33 13.64 59 75405 3995 110509840
Wheezing 122.55 13.64 15 75449 255215 110258620
Glossodynia 120.10 13.64 8 75456 221996 110291839
Respiratory distress 118.38 13.64 187 75277 68687 110445148
Hand deformity 117.84 13.64 8 75456 218498 110295337
Fatigue 116.18 13.64 433 75031 1215525 109298310
Therapeutic product effect decreased 113.37 13.64 16 75448 244300 110269535
Bradykinesia 111.15 13.64 77 75387 10711 110503124
Dystonic tremor 108.29 13.64 29 75435 348 110513487
Suicidal ideation 108.23 13.64 214 75250 93723 110420112
Cardio-respiratory arrest 108.00 13.64 242 75222 115594 110398241
Off label use 107.62 13.64 594 74870 1499591 109014244
Oxygen saturation decreased 107.16 13.64 291 75173 156691 110357144
Respiratory acidosis 104.78 13.64 82 75382 13744 110500091
Behaviour disorder 104.46 13.64 71 75393 9576 110504259
Visceral congestion 104.42 13.64 38 75426 1307 110512528
Nasopharyngitis 103.76 13.64 71 75393 394290 110119545
Reduced facial expression 102.47 13.64 50 75414 3601 110510234
Dysarthria 102.22 13.64 196 75268 83925 110429910
Loss of consciousness 101.73 13.64 330 75134 195976 110317859
Creatinine renal clearance increased 99.81 13.64 49 75415 3576 110510259
Victim of crime 99.70 13.64 37 75427 1346 110512489
Contraindicated product administered 98.65 13.64 24 75440 248243 110265592
Victim of sexual abuse 98.03 13.64 29 75435 510 110513325
Pain in extremity 97.80 13.64 113 75351 487005 110026830
Neuroleptic malignant syndrome 97.02 13.64 118 75346 33941 110479894
Alopecia 95.51 13.64 66 75398 364687 110149148
Tachycardia 94.90 13.64 355 75109 226290 110287545
Housebound 93.42 13.64 27 75437 436 110513399
Impaired healing 90.98 13.64 13 75451 196704 110317131
Lactic acidosis 88.87 13.64 196 75268 92615 110421220
Urticaria 88.51 13.64 54 75410 318803 110195032
Alcohol abuse 88.33 13.64 50 75414 4879 110508956
Hypoaesthesia 87.52 13.64 53 75411 314170 110199665
Cough 87.47 13.64 112 75352 461529 110052306
Wound 86.85 13.64 26 75438 234411 110279424
Irritable bowel syndrome 85.72 13.64 7 75457 164208 110349627
Pneumonia 84.34 13.64 311 75153 876403 109637432
Pulmonary oedema 83.62 13.64 201 75263 100458 110413377
Withdrawal syndrome 83.41 13.64 105 75359 31275 110482560
Blister 82.82 13.64 26 75438 227350 110286485
Fibromyalgia 82.14 13.64 10 75454 170899 110342936
Renal function test abnormal 80.97 13.64 59 75405 8887 110504948
Pruritus 80.55 13.64 173 75291 581387 109932448
Asthma 78.87 13.64 36 75428 250255 110263580
Brain oedema 77.84 13.64 101 75363 30997 110482838
Platelet count decreased 77.66 13.64 30 75434 230413 110283422
Gastrointestinal disorder 77.49 13.64 34 75430 241918 110271917
Multiple drug therapy 77.44 13.64 55 75409 7959 110505876
Urinary retention 76.97 13.64 156 75308 69527 110444308
Hepatic enzyme increased 75.18 13.64 65 75399 320827 110193008
Bradyphrenia 75.01 13.64 63 75401 11665 110502170
Therapy non-responder 73.67 13.64 10 75454 157297 110356538
Pyrexia 73.08 13.64 340 75124 897925 109615910
Encephalopathy 72.93 13.64 167 75297 80888 110432947
Bursitis 72.31 13.64 4 75460 129914 110383921
Mixed liver injury 71.37 13.64 62 75402 12017 110501818
Back pain 71.30 13.64 89 75375 370907 110142928
Faecal vomiting 71.12 13.64 30 75434 1536 110512299
Apathy 70.13 13.64 70 75394 16169 110497666
COVID-19 70.11 13.64 40 75424 245020 110268815
Accidental overdose 69.50 13.64 126 75338 51708 110462127
Agranulocytosis 69.09 13.64 139 75325 61621 110452214
Toxic epidermal necrolysis 67.47 13.64 131 75333 56596 110457239
Injection site pain 67.24 13.64 19 75445 177903 110335932
Disease progression 65.41 13.64 43 75421 243991 110269844
Akathisia 65.27 13.64 69 75395 17044 110496791
Prescription form tampering 65.01 13.64 21 75443 500 110513335
White blood cell count decreased 63.43 13.64 39 75425 229351 110284484
Infection 63.42 13.64 93 75371 362107 110151728
Potentiating drug interaction 63.28 13.64 57 75407 11586 110502249
Cardiac failure congestive 63.18 13.64 13 75451 150987 110362848
Chest pain 62.67 13.64 100 75364 376275 110137560
Ill-defined disorder 62.61 13.64 15 75449 156838 110356997
Upper respiratory tract infection 62.33 13.64 8 75456 131320 110382515
Nausea 62.28 13.64 542 74922 1235148 109278687
Weight increased 60.44 13.64 122 75342 419522 110094313
Drug level increased 60.20 13.64 113 75351 47606 110466229
Hepatitis acute 60.04 13.64 69 75395 18697 110495138
Type 2 diabetes mellitus 59.83 13.64 23 75441 177209 110336626
Blood cholesterol increased 59.11 13.64 26 75438 184759 110329076
Chemical submission 58.85 13.64 20 75444 560 110513275
Sepsis 58.34 13.64 83 75381 327263 110186572
Victim of chemical submission 57.85 13.64 22 75442 857 110512978
Drug screen positive 57.39 13.64 42 75422 6368 110507467
Vasoplegia syndrome 56.45 13.64 39 75425 5400 110508435
Patient uncooperative 55.97 13.64 22 75442 938 110512897
Myoclonus 55.86 13.64 89 75375 32909 110480926
Listless 55.59 13.64 36 75428 4479 110509356
Diarrhoea 55.54 13.64 504 74960 1139001 109374834
Night sweats 55.10 13.64 12 75452 133971 110379864
Cholestatic liver injury 54.28 13.64 43 75421 7333 110506502
Osteoarthritis 53.40 13.64 29 75435 182594 110331241
Abdominal pain upper 53.31 13.64 98 75366 349013 110164822
Hypokalaemia 53.16 13.64 256 75208 182192 110331643
Benzodiazepine drug level increased 52.44 13.64 15 75449 233 110513602
Migraine 50.56 13.64 27 75437 171625 110342210
Hallucination 50.25 13.64 168 75296 101264 110412571
Rash maculo-papular 50.02 13.64 137 75327 74085 110439750
Myelosuppression 49.29 13.64 4 75460 94336 110419499
Neuropathy peripheral 48.83 13.64 31 75433 179246 110334589
Muscle spasms 48.11 13.64 72 75392 278085 110235750
Muscle rigidity 48.01 13.64 70 75394 23961 110489874
Status epilepticus 47.84 13.64 81 75383 31490 110482345
Psychotic behaviour 47.59 13.64 22 75442 1403 110512432
Accidental death 47.53 13.64 34 75430 4975 110508860
Haemodynamic instability 46.20 13.64 67 75397 22821 110491014
Psychotic disorder 45.87 13.64 105 75359 50832 110463003
Musculoskeletal pain 45.42 13.64 35 75429 182988 110330847
Sciatica 45.40 13.64 5 75459 92394 110421441
Musculoskeletal stiffness 45.02 13.64 76 75388 279746 110234089
Eosinophilia 44.20 13.64 112 75352 57824 110456011
Dry skin 43.55 13.64 10 75454 107643 110406192
Peripheral venous disease 42.76 13.64 4 75460 84113 110429722
Contusion 42.73 13.64 58 75406 233303 110280532
Neutrophil count decreased 41.98 13.64 15 75449 120926 110392909
Dry mouth 41.58 13.64 45 75419 199903 110313932
Vascular purpura 41.41 13.64 28 75436 3743 110510092
Accidental poisoning 41.28 13.64 24 75440 2463 110511372
Hyper IgE syndrome 41.09 13.64 16 75448 665 110513170
Injury 40.18 13.64 37 75427 177228 110336607
Homicide 39.85 13.64 18 75446 1088 110512747
Tremor 39.66 13.64 255 75209 201977 110311858
Hyperkalaemia 39.16 13.64 190 75274 135606 110378229
Red blood cell sedimentation rate increased 39.08 13.64 4 75460 78298 110435537
Drug withdrawal convulsions 38.98 13.64 23 75441 2426 110511409
Pleurothotonus 38.56 13.64 23 75441 2475 110511360
Thrombosis 38.54 13.64 13 75451 108649 110405186
Liver injury 38.30 13.64 28 75436 150385 110363450
Metabolic acidosis 38.23 13.64 152 75312 99592 110414243
Wrong product administered 37.96 13.64 42 75422 10918 110502917
Completed suicide 37.78 13.64 289 75175 242092 110271743
Drug level above therapeutic 37.73 13.64 43 75421 11545 110502290
Dyspepsia 37.51 13.64 45 75419 190920 110322915
Drug ineffective for unapproved indication 37.00 13.64 12 75452 102826 110411009
Wound infection 37.00 13.64 10 75454 96455 110417380
Hospitalisation 36.97 13.64 26 75438 142467 110371368
Aspiration 36.90 13.64 71 75393 30462 110483373
Gastrooesophageal reflux disease 36.88 13.64 41 75423 179935 110333900
Persecutory delusion 36.58 13.64 32 75432 6259 110507576
Mania 36.46 13.64 57 75407 20739 110493096
Inflammation 36.42 13.64 47 75417 193191 110320644
Hypotonia 36.11 13.64 49 75415 15696 110498139
Psychomotor skills impaired 35.33 13.64 33 75431 7025 110506810
Adverse drug reaction 35.12 13.64 14 75450 105545 110408290
Asthenia 35.12 13.64 301 75163 688698 109825137
Small fibre neuropathy 35.11 13.64 16 75448 987 110512848
Sudden death 34.88 13.64 61 75403 24334 110489501
Dyspnoea 34.76 13.64 539 74925 1106333 109407502
Pancreatitis acute 34.57 13.64 105 75359 60169 110453666
Psoriasis 34.44 13.64 27 75437 139966 110373869
Nasal congestion 34.44 13.64 12 75452 98270 110415565
Hypertonia 34.04 13.64 35 75429 8371 110505464
Hypercapnia 33.97 13.64 40 75424 11119 110502716
Wrong rate 33.96 13.64 10 75454 173 110513662
Anterograde amnesia 33.74 13.64 15 75449 873 110512962
Prothrombin time ratio decreased 33.62 13.64 18 75446 1574 110512261
Abdominal distension 33.61 13.64 42 75422 175061 110338774
Liver disorder 33.06 13.64 29 75435 142214 110371621
Generalised tonic-clonic seizure 33.01 13.64 97 75367 54583 110459252
Injection site reaction 32.75 13.64 10 75454 89060 110424775
Adverse event 32.21 13.64 17 75447 108792 110405043
Oesophageal obstruction 31.85 13.64 16 75448 1227 110512608
Cerebral haematoma 31.80 13.64 36 75428 9596 110504239
Dyskinesia 31.76 13.64 92 75372 51354 110462481
Hypoventilation 31.56 13.64 33 75431 8048 110505787
Mutism 31.56 13.64 22 75442 3091 110510744
Delirium 31.40 13.64 178 75286 134847 110378988
Antipsychotic drug level above therapeutic 31.39 13.64 20 75444 2420 110511415
Injection site swelling 31.25 13.64 3 75461 61787 110452048
Live birth 31.18 13.64 5 75459 69479 110444356
Maternal exposure during pregnancy 31.09 13.64 81 75383 254802 110259033
Cataract 30.94 13.64 8 75456 79477 110434358
Intentional product use issue 30.84 13.64 78 75386 247828 110266007
C-reactive protein increased 30.80 13.64 64 75400 217855 110295980
Tardive dyskinesia 30.75 13.64 42 75422 13537 110500298
Psychomotor hyperactivity 30.69 13.64 52 75412 20225 110493610
Vertigo 30.62 13.64 129 75335 86741 110427094
Arterial intramural haematoma 30.57 13.64 10 75454 248 110513587
Therapeutic product effect incomplete 30.57 13.64 67 75397 223738 110290097
Injection site erythema 30.51 13.64 13 75451 94163 110419672
Rhinorrhoea 30.45 13.64 16 75448 102650 110411185
Victim of homicide 30.38 13.64 10 75454 253 110513582
Flushing 30.08 13.64 17 75447 104719 110409116
Prescription drug used without a prescription 30.05 13.64 27 75437 5469 110508366
Delusion 29.65 13.64 56 75408 23699 110490136
Drug withdrawal syndrome 29.48 13.64 74 75390 37980 110475855
Troponin T increased 29.35 13.64 24 75440 4282 110509553
Obesity 28.99 13.64 21 75443 113330 110400505
Oropharyngeal pain 28.62 13.64 30 75434 135246 110378589
Paraesthesia 28.56 13.64 95 75369 276426 110237409
Hypovolaemic shock 28.44 13.64 42 75422 14541 110499294
Blood thyroid stimulating hormone normal 28.41 13.64 8 75456 117 110513718
Arthritis 28.36 13.64 44 75420 167542 110346293
Melanoderma 28.21 13.64 11 75453 459 110513376
Condition aggravated 27.97 13.64 344 75120 734492 109779343
Colitis ulcerative 27.88 13.64 9 75455 77354 110436481
Foreign body 27.67 13.64 20 75444 2975 110510860
Shock 27.65 13.64 90 75374 53498 110460337
Full blood count abnormal 27.62 13.64 3 75461 56049 110457786
Drug reaction with eosinophilia and systemic symptoms 27.46 13.64 120 75344 81975 110431860
Arteriosclerosis coronary artery 27.45 13.64 56 75408 25062 110488773
Major depression 27.37 13.64 35 75429 10586 110503249
Pulmonary congestion 26.96 13.64 63 75401 30903 110482932
Oedema 26.95 13.64 65 75399 209911 110303924
Gait inability 26.93 13.64 32 75432 136344 110377491
Sinus tachycardia 26.92 13.64 79 75385 44414 110469421
On and off phenomenon 26.73 13.64 23 75441 4401 110509434
Cytomegalovirus infection 26.61 13.64 3 75461 54441 110459394
Subileus 26.43 13.64 27 75437 6410 110507425
Frequent bowel movements 26.27 13.64 8 75456 71382 110442453
Antipsychotic drug level increased 26.25 13.64 28 75436 6987 110506848
Insomnia 26.07 13.64 142 75322 360448 110153387
Road traffic accident 26.06 13.64 21 75443 107377 110406458
Traumatic haemothorax 26.04 13.64 12 75452 760 110513075
Pulmonary fibrosis 25.97 13.64 19 75445 102023 110411812
Therapeutic response decreased 25.84 13.64 17 75447 96482 110417353
Hyperdynamic left ventricle 25.75 13.64 11 75453 581 110513254
Urinary tract infection 25.55 13.64 125 75339 326157 110187678
Product use issue 25.23 13.64 118 75346 311577 110202258
Decreased appetite 25.06 13.64 206 75258 475640 110038195
Erythema 24.99 13.64 108 75356 291339 110222496
Gamma-glutamyltransferase increased 24.77 13.64 95 75369 61214 110452621
Drug diversion 24.73 13.64 14 75450 1366 110512469
Tachyphrenia 24.70 13.64 17 75447 2339 110511496
Injection site bruising 24.62 13.64 3 75461 51260 110462575
Injection site pruritus 24.62 13.64 3 75461 51255 110462580
Influenza 24.45 13.64 49 75415 169052 110344783
Muscle contracture 24.24 13.64 18 75446 2790 110511045
Salivary hypersecretion 24.18 13.64 43 75421 17378 110496457
Haematoma muscle 24.17 13.64 21 75443 4069 110509766
Acute respiratory distress syndrome 23.64 13.64 85 75379 53113 110460722
Sinus bradycardia 23.54 13.64 58 75406 29425 110484410
Tongue biting 23.51 13.64 18 75446 2921 110510914
Irritability 23.51 13.64 79 75385 47730 110466105
Hallucination, synaesthetic 23.40 13.64 6 75458 60 110513775
Muscular weakness 23.23 13.64 89 75375 248379 110265456
Neck pain 23.15 13.64 30 75434 123100 110390735
Mesenteric vein thrombosis 22.36 13.64 15 75449 1980 110511855
Hypoosmolar state 22.33 13.64 9 75455 410 110513425
Haematoma 22.31 13.64 89 75375 58387 110455448
Joint stiffness 22.23 13.64 9 75455 67234 110446601
Blood glucose increased 22.22 13.64 35 75429 132461 110381374
Fluid retention 22.19 13.64 19 75445 94288 110419547
Visceral oedema 22.18 13.64 6 75458 75 110513760
Loss of personal independence in daily activities 22.10 13.64 43 75421 149977 110363858
Galactorrhoea 21.91 13.64 20 75444 4135 110509700
Hypereosinophilic syndrome 21.90 13.64 11 75453 843 110512992
Eosinophilic myocarditis 21.76 13.64 15 75449 2070 110511765
Hypercholesterolaemia 21.74 13.64 18 75446 90819 110423016
Death 21.62 13.64 627 74837 698242 109815593
Hepatic fibrosis 21.45 13.64 27 75437 8039 110505796
Cellulitis 21.40 13.64 33 75431 125983 110387852
Discomfort 21.32 13.64 75 75389 214632 110299203
Hypocoagulable state 20.88 13.64 16 75448 2599 110511236
Oesophageal haemorrhage 20.59 13.64 14 75450 1889 110511946
Dissociative disorder 20.57 13.64 12 75452 1239 110512596
Antasthmatic drug level 20.49 13.64 5 75459 40 110513795
Single umbilical artery 20.45 13.64 4 75460 9 110513826
Antidepressant drug level above therapeutic 20.15 13.64 10 75454 747 110513088
Pregnancy 20.15 13.64 5 75459 51062 110462773
Wrong technique in product usage process 20.06 13.64 18 75446 87330 110426505
Adjustment disorder with depressed mood 20.05 13.64 3 75461 43880 110469955
Analgesic drug level 19.97 13.64 5 75459 45 110513790
Pre-eclampsia 19.96 13.64 27 75437 8623 110505212
Cholinergic syndrome 19.87 13.64 12 75452 1320 110512515
Haematochezia 19.86 13.64 30 75434 115494 110398341
Acetonaemia 19.74 13.64 9 75455 556 110513279
Torsade de pointes 19.70 13.64 46 75418 22554 110491281
Apnoea 19.36 13.64 34 75430 13605 110500230
Psychotic symptom 19.20 13.64 18 75446 3849 110509986
Parkinsonism 19.17 13.64 45 75419 22142 110491693
Laryngitis 19.15 13.64 3 75461 42408 110471427
Skin exfoliation 19.03 13.64 19 75445 87632 110426203
Neurosensory hypoacusis 18.98 13.64 7 75457 250 110513585
Dyspnoea exertional 18.90 13.64 26 75438 104034 110409801
Cardiac pacemaker evaluation 18.85 13.64 6 75458 136 110513699
Vestibular disorder 18.63 13.64 15 75449 2617 110511218
Tonic convulsion 18.61 13.64 16 75448 3058 110510777
Disturbance in social behaviour 18.59 13.64 20 75444 5038 110508797
Weight decreased 18.59 13.64 217 75247 467840 110045995
Hypomagnesaemia 18.51 13.64 86 75378 60284 110453551
Pelvic fracture 18.45 13.64 34 75430 14120 110499715
Chest discomfort 18.44 13.64 59 75405 173789 110340046
Plasma cell myeloma 18.38 13.64 10 75454 62926 110450909
Influenza like illness 18.26 13.64 20 75444 88392 110425443
Fungal infection 18.15 13.64 6 75458 50800 110463035
Opiates positive 18.12 13.64 10 75454 929 110512906
Malignant neoplasm progression 18.00 13.64 60 75404 174507 110339328
Cardiac hypertrophy 17.98 13.64 13 75451 1934 110511901
Anal paraesthesia 17.85 13.64 4 75460 21 110513814
Ear pain 17.80 13.64 7 75457 53219 110460616
Spinal cord injury thoracic 17.76 13.64 6 75458 165 110513670
Hepatic failure 17.57 13.64 93 75371 68646 110445189
Psychomotor retardation 17.49 13.64 24 75440 7768 110506067
Food aversion 17.49 13.64 12 75452 1643 110512192
Analgesic drug level above therapeutic 17.44 13.64 8 75456 501 110513334
Chills 17.34 13.64 69 75395 190511 110323324
Haematocrit decreased 17.23 13.64 12 75452 66105 110447730
Mucosa vesicle 17.20 13.64 6 75458 182 110513653
Cystitis 17.19 13.64 12 75452 66024 110447811
Chronic kidney disease 17.19 13.64 16 75448 76275 110437560
Red blood cell count decreased 17.14 13.64 12 75452 65911 110447924
Neurological examination abnormal 17.05 13.64 9 75455 765 110513070
Oedema peripheral 16.96 13.64 143 75321 328517 110185318
Phlebotomy 16.95 13.64 5 75459 87 110513748
Head discomfort 16.92 13.64 39 75425 18961 110494874
Retrograde amnesia 16.91 13.64 9 75455 778 110513057
Clonus 16.85 13.64 25 75439 8691 110505144
Foot deformity 16.84 13.64 6 75458 48474 110465361
22q11.2 deletion syndrome 16.79 13.64 3 75461 3 110513832
Dizziness 16.79 13.64 356 75108 697837 109815998
Poor feeding infant 16.75 13.64 6 75458 197 110513638
Cerebral haemorrhage 16.68 13.64 88 75376 64880 110448955
Acute generalised exanthematous pustulosis 16.64 13.64 42 75422 21622 110492213
Stress 16.57 13.64 29 75435 105319 110408516
Therapy cessation 16.56 13.64 5 75459 44852 110468983
Colitis ischaemic 16.43 13.64 37 75427 17713 110496122
Blood pressure increased 16.41 13.64 106 75358 258267 110255568
Throat irritation 16.40 13.64 8 75456 53544 110460291
Foetal alcohol syndrome 16.40 13.64 4 75460 32 110513803
Coagulation factor VII level decreased 16.25 13.64 6 75458 215 110513620
Incoherent 16.19 13.64 24 75440 8334 110505501
Acute myocardial infarction 16.17 13.64 20 75444 83757 110430078
Product administration error 16.14 13.64 59 75405 37158 110476677
Lymphadenopathy 16.10 13.64 12 75452 63823 110450012
Feeling abnormal 16.08 13.64 66 75398 180645 110333190
Herpes zoster 16.01 13.64 31 75433 108348 110405487
Diabetes mellitus 15.96 13.64 27 75437 99354 110414481
Toxic skin eruption 15.84 13.64 48 75416 27467 110486368
Megacolon 15.78 13.64 17 75447 4288 110509547
Diarrhoea infectious 15.78 13.64 12 75452 1928 110511907
Hypoglycaemia 15.67 13.64 134 75330 115970 110397865
Exposure during pregnancy 15.63 13.64 60 75404 167364 110346471
Joint injury 15.61 13.64 4 75460 39990 110473845
Cardioactive drug level above therapeutic 15.56 13.64 6 75458 243 110513592
Obstructive airways disorder 15.55 13.64 6 75458 46143 110467692
Obstructive pancreatitis 15.54 13.64 10 75454 1231 110512604
N-terminal prohormone brain natriuretic peptide increased 15.50 13.64 20 75444 6101 110507734
Anuria 15.48 13.64 44 75420 24297 110489538
Food craving 15.44 13.64 12 75452 1991 110511844
Hypertension 15.40 13.64 250 75214 509834 110004001
Feeling hot 15.34 13.64 24 75440 91082 110422753
Emotional disorder 15.31 13.64 34 75430 16126 110497709
Abdominal pain 15.30 13.64 252 75212 512737 110001098
Myalgia 15.29 13.64 89 75375 222292 110291543
Onychomadesis 15.28 13.64 6 75458 45657 110468178
Atopic keratoconjunctivitis 15.17 13.64 4 75460 45 110513790
Medulloblastoma 15.14 13.64 5 75459 128 110513707
Theft 15.06 13.64 6 75458 265 110513570
Respiratory alkalosis 14.97 13.64 19 75445 5702 110508133
No adverse event 14.92 13.64 17 75447 73822 110440013
Action tremor 14.87 13.64 7 75457 465 110513370
Subcutaneous haematoma 14.82 13.64 14 75450 3022 110510813
Inappropriate schedule of product administration 14.81 13.64 80 75384 203557 110310278
Substance abuser 14.80 13.64 7 75457 470 110513365
Underdose 14.71 13.64 13 75451 63541 110450294
Nightmare 14.71 13.64 59 75405 38804 110475031
Renal tubular necrosis 14.67 13.64 50 75414 30425 110483410
Rash pruritic 14.53 13.64 28 75436 98041 110415794
Acquired haemophilia 14.53 13.64 13 75451 2618 110511217
Surgery 14.53 13.64 5 75459 41278 110472557
Thinking abnormal 14.51 13.64 32 75432 15108 110498727
Coordination abnormal 14.51 13.64 44 75420 25184 110488651
Consciousness fluctuating 14.46 13.64 12 75452 2184 110511651
Prothrombin time shortened 14.44 13.64 15 75449 3631 110510204
Pancreas infection 14.37 13.64 7 75457 502 110513333
Ear infection 14.32 13.64 13 75451 62719 110451116
Post-injection delirium sedation syndrome 14.32 13.64 8 75456 761 110513074
Hypercapnic coma 14.29 13.64 7 75457 508 110513327
Hyperkinesia 14.26 13.64 14 75450 3170 110510665
Ascites 14.19 13.64 26 75438 92782 110421053
Kidney congestion 14.12 13.64 7 75457 522 110513313
Dystonia 13.91 13.64 44 75420 25761 110488074
Prescribed overdose 13.88 13.64 24 75440 87557 110426278
Cerebrovascular accident 13.87 13.64 70 75394 181214 110332621
Mental status changes 13.84 13.64 19 75445 76103 110437732
Head injury 13.72 13.64 62 75402 42955 110470880
Atonic seizures 13.71 13.64 9 75455 1145 110512690
High-pitched crying 13.68 13.64 3 75461 14 110513821

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Withdrawal syndrome 61.49 47.52 19 171 157 113606

Pharmacologic Action:

SourceCodeDescription
ATC N05BA04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
FDA EPC N0000175694 Benzodiazepine
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

N05BA Benzodiazepine derivatives 23 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Alcohol withdrawal delirium indication 8635005
Anxiety indication 48694002
Suicidal thoughts contraindication 6471006
Disorder of lung contraindication 19829001 DOID:850
Borderline personality disorder contraindication 20010003 DOID:10930
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Depressive disorder contraindication 35489007
Low blood pressure contraindication 45007003
Substance abuse contraindication 66214007
Psychotic disorder contraindication 69322001
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Hypoalbuminemia contraindication 119247004
Disease of liver contraindication 235856003 DOID:409
Sleep automatism contraindication 247962006
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Coma contraindication 371632003
Porphyria contraindication 418470004
Behavioral Disorders contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.41 acidic
pKa2 11.87 acidic
pKa3 1.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR IC50 7.75 WOMBAT-PK CHEMBL

External reference:

IDSource
4018020 VUID
N0000146364 NUI
D00464 KEGG_DRUG
4018020 VANDF
C0029997 UMLSCUI
CHEBI:7823 CHEBI
CHEMBL568 ChEMBL_ID
DB00842 DRUGBANK_ID
D010076 MESH_DESCRIPTOR_UI
4616 PUBCHEM_CID
7253 IUPHAR_LIGAND_ID
1507 INN_ID
6GOW6DWN2A UNII
7781 RXNORM
4493 MMSL
5211 MMSL
d00040 MMSL
001462 NDDF
387455006 SNOMEDCT_US
79225003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2067 CAPSULE, GELATIN COATED 10 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2067 CAPSULE, GELATIN COATED 10 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2069 CAPSULE, GELATIN COATED 15 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2069 CAPSULE, GELATIN COATED 15 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2073 CAPSULE, GELATIN COATED 30 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2073 CAPSULE, GELATIN COATED 30 mg ORAL ANDA 21 sections
OXAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-304 CAPSULE 15 mg ORAL ANDA 13 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 43353-074 CAPSULE, GELATIN COATED 30 mg ORAL ANDA 19 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 52817-290 CAPSULE 10 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 52817-291 CAPSULE 15 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 52817-292 CAPSULE 30 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 62584-812 CAPSULE, GELATIN COATED 10 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 62584-813 CAPSULE, GELATIN COATED 15 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 62584-814 CAPSULE, GELATIN COATED 30 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 67544-117 CAPSULE, GELATIN COATED 10 mg ORAL ANDA 19 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 67544-268 CAPSULE, GELATIN COATED 15 mg ORAL ANDA 19 sections
OXAZEPAM Human Prescription Drug Label 1 69315-911 CAPSULE 10 mg ORAL ANDA 26 sections
OXAZEPAM Human Prescription Drug Label 1 69315-912 CAPSULE 15 mg ORAL ANDA 26 sections
OXAZEPAM Human Prescription Drug Label 1 69315-913 CAPSULE 30 mg ORAL ANDA 26 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 71610-639 CAPSULE 15 mg ORAL ANDA 21 sections