oxazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	2015	604-75-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: oxazepam droxacepam durazepam noctazepam tazepam zaxopam	A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia. Molecular weight: 286.72 Formula: C15H11ClN2O2 CLOGP: 2.31 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 61.69 ALOGS: -3.51 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

oxazepam
droxacepam
durazepam
noctazepam
tazepam
zaxopam

A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.

Molecular weight: 286.72
Formula: C15H11ClN2O2
CLOGP: 2.31
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 61.69
ALOGS: -3.51
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
50	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.05 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	6.98 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	97 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.59 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.10 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.04 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	6.70 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
June 4, 1965	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	1284.63	13.69	1102	35476	223462	56032027
Depressed level of consciousness	939.05	13.69	535	36043	55898	56199591
Intentional overdose	865.98	13.69	543	36035	67574	56187915
Orthostatic hypotension	862.60	13.69	424	36154	32775	56222714
Sedation complication	786.35	13.69	293	36285	11379	56244110
Sedation	778.93	13.69	402	36176	34452	56221037
Coma	761.69	13.69	477	36101	59178	56196311
Creatinine renal clearance decreased	726.89	13.69	294	36284	14265	56241224
Cognitive disorder	680.78	13.69	414	36164	48719	56206770
Poisoning deliberate	638.17	13.69	241	36337	9712	56245777
Blood calcium decreased	588.72	13.69	294	36284	23475	56232014
Fall	557.38	13.69	900	35678	356610	55898879
Intentional self-injury	520.22	13.69	275	36303	24717	56230772
Hypotension	496.72	13.69	706	35872	249802	56005687
Balance disorder	481.23	13.69	398	36180	76122	56179367
Somnolence	383.04	13.69	500	36078	162913	56092576
Suicide attempt	361.71	13.69	300	36278	57536	56197953
Mobility decreased	293.15	13.69	341	36237	98650	56156839
Drug abuse	283.30	13.69	280	36298	67330	56188159
Hyponatraemia	274.69	13.69	335	36243	101804	56153685
Constipation	257.33	13.69	466	36112	201477	56054012
Drug ineffective	230.41	13.69	159	36419	918830	55336659
Overdose	208.47	13.69	298	36280	105532	56149957
Electrocardiogram QT prolonged	201.14	13.69	211	36367	54377	56201112
Drug dependence	175.30	13.69	133	36445	22400	56233089
Rheumatoid arthritis	173.97	13.69	22	36556	382582	55872907
Drug interaction	171.17	13.69	403	36175	209352	56046137
Miosis	144.06	13.69	75	36503	6517	56248972
Hepatocellular injury	138.13	13.69	124	36454	26390	56229099
Bradycardia	134.16	13.69	191	36387	67313	56188176
Confusional state	131.33	13.69	363	36215	207792	56047697
Rash	130.17	13.69	80	36498	492967	55762522
Asphyxia	126.89	13.69	66	36512	5723	56249766
Abdominal discomfort	121.07	13.69	18	36560	277256	55978233
Prescription form tampering	119.88	13.69	34	36544	539	56254950
Drug intolerance	107.22	13.69	21	36557	264797	55990692
Drug hypersensitivity	104.96	13.69	25	36553	275180	55980309
Pneumonia aspiration	104.82	13.69	117	36461	32294	56223195
Cholestasis	104.41	13.69	107	36471	26806	56228683
Rhabdomyolysis	102.12	13.69	129	36449	40529	56214960
Joint swelling	96.44	13.69	34	36544	289766	55965723
Arthralgia	96.04	13.69	111	36467	501558	55753931
Product dose omission issue	94.83	13.69	11	36567	204742	56050747
Arthropathy	92.15	13.69	11	36567	200264	56055225
Hypothermia	89.10	13.69	70	36508	12400	56243089
Swelling	89.04	13.69	23	36555	239748	56015741
Pemphigus	88.71	13.69	3	36575	157209	56098280
Peripheral swelling	88.16	13.69	22	36556	234704	56020785
Sinusitis	88.13	13.69	12	36566	197569	56057920
Respiratory depression	87.12	13.69	69	36509	12366	56243123
Wrong patient received product	85.30	13.69	37	36541	2134	56253355
Inappropriate antidiuretic hormone secretion	85.13	13.69	71	36507	13685	56241804
Aggression	82.67	13.69	86	36492	21920	56233569
Glossodynia	82.35	13.69	4	36574	152454	56103035
Hypersensitivity	80.42	13.69	33	36545	256375	55999114
Hallucination, visual	79.92	13.69	76	36502	17392	56238097
Hypokalaemia	72.05	13.69	177	36401	94260	56161229
Lactic acidosis	70.16	13.69	100	36478	35246	56220243
Therapeutic product effect decreased	67.36	13.69	14	36564	169438	56086051
Contraindicated product administered	67.01	13.69	19	36559	186267	56069222
Infusion related reaction	65.32	13.69	27	36551	208904	56046585
Bladder dilatation	64.89	13.69	23	36555	770	56254719
Acute kidney injury	64.38	13.69	318	36260	240445	56015044
Altered state of consciousness	64.18	13.69	77	36501	22944	56232545
Headache	63.93	13.69	171	36407	558873	55696616
Bradypnoea	63.07	13.69	34	36544	3169	56252320
Alopecia	62.71	13.69	59	36519	293399	55962090
Fatigue	60.93	13.69	285	36293	788267	55467222
Reduced facial expression	58.99	13.69	27	36551	1769	56253720
Victim of sexual abuse	58.79	13.69	20	36558	591	56254898
Hand deformity	58.02	13.69	9	36569	134483	56121006
Akathisia	56.33	13.69	46	36532	8606	56246883
Infection	56.22	13.69	30	36548	200176	56055313
Lower respiratory tract infection	56.15	13.69	5	36573	114789	56140700
Loss of consciousness	54.85	13.69	176	36402	109173	56146316
Disturbance in attention	54.46	13.69	85	36493	32455	56223034
Intentional product misuse	54.44	13.69	110	36468	51394	56204095
Hyperthermia	51.75	13.69	43	36535	8242	56247247
Respiratory acidosis	51.53	13.69	38	36540	6125	56249364
Agitation	51.46	13.69	113	36465	55923	56199566
Injection site pain	50.14	13.69	8	36570	117110	56138379
Urinary retention	49.32	13.69	75	36503	27999	56227490
Drug use disorder	48.81	13.69	33	36545	4636	56250853
Mydriasis	48.43	13.69	47	36531	11024	56244465
Restlessness	48.09	13.69	72	36506	26514	56228975
Oxygen saturation decreased	47.87	13.69	136	36442	78931	56176558
Benzodiazepine drug level increased	47.80	13.69	13	36565	175	56255314
Blister	47.62	13.69	7	36571	108880	56146609
Listless	46.48	13.69	26	36552	2606	56252883
Poisoning	46.20	13.69	49	36529	12764	56242725
Stomatitis	45.95	13.69	11	36567	120799	56134690
Nasopharyngitis	45.35	13.69	46	36532	220913	56034576
Suicidal ideation	43.77	13.69	108	36470	57634	56197855
Pericarditis	43.27	13.69	9	36569	108914	56146575
Wound	43.26	13.69	18	36560	138786	56116703
Potentiating drug interaction	43.13	13.69	29	36549	4037	56251452
Apathy	42.99	13.69	38	36540	7916	56247573
Back pain	42.58	13.69	55	36523	237115	56018374
Hypotonia	42.08	13.69	39	36539	8638	56246851
Neuroleptic malignant syndrome	41.57	13.69	44	36534	11434	56244055
Off label use	40.51	13.69	205	36373	555975	55699514
Faecal vomiting	40.22	13.69	15	36563	582	56254907
Cough	40.11	13.69	67	36511	259894	55995595
Tachycardia	39.80	13.69	155	36423	105721	56149768
Haemodynamic instability	39.55	13.69	37	36541	8292	56247197
Mixed liver injury	39.15	13.69	27	36551	3917	56251572
Extrapyramidal disorder	38.90	13.69	44	36534	12312	56243177
Pain in extremity	38.61	13.69	85	36493	297346	55958143
Patient uncooperative	38.40	13.69	11	36567	181	56255308
Substance abuse	38.05	13.69	28	36550	4497	56250992
Pneumonia	37.61	13.69	137	36441	406961	55848528
Cardiac failure congestive	37.53	13.69	6	36572	87714	56167775
Serotonin syndrome	37.29	13.69	64	36514	26426	56229063
Disorientation	37.27	13.69	77	36501	36536	56218953
Delirium	37.08	13.69	84	36494	42433	56213056
Prescription drug used without a prescription	36.17	13.69	20	36558	1960	56253529
Muscle rigidity	35.31	13.69	39	36539	10632	56244857
Hypocoagulable state	35.24	13.69	16	36562	1029	56254460
Wheezing	34.78	13.69	4	36574	75022	56180467
Encephalopathy	34.45	13.69	73	36505	35252	56220237
On and off phenomenon	34.12	13.69	18	36560	1606	56253883
Abnormal behaviour	33.98	13.69	53	36525	20219	56235270
Hepatic enzyme increased	33.67	13.69	37	36541	171347	56084142
Accidental overdose	33.61	13.69	53	36525	20408	56235081
Hyperkalaemia	33.25	13.69	90	36488	50775	56204714
Housebound	32.27	13.69	10	36568	218	56255271
Drug level above therapeutic	32.27	13.69	25	36553	4337	56251152
Multiple drug therapy	32.25	13.69	21	36557	2771	56252718
Hypoventilation	32.12	13.69	25	36553	4367	56251122
Epilepsy	31.70	13.69	58	36520	25173	56230316
Pyrexia	31.22	13.69	153	36425	418620	55836869
Hallucination	31.17	13.69	86	36492	49063	56206426
Behaviour disorder	30.34	13.69	20	36558	2693	56252796
Eosinophilia	30.24	13.69	50	36528	20027	56235462
Hypereosinophilic syndrome	30.22	13.69	10	36568	271	56255218
White blood cell count decreased	29.71	13.69	23	36555	125967	56129522
Prothrombin time ratio decreased	29.71	13.69	11	36567	418	56255071
Foreign body	29.52	13.69	18	36560	2118	56253371
Hepatic infiltration eosinophilic	29.03	13.69	6	36572	21	56255468
Respiratory alkalosis	29.00	13.69	19	36559	2532	56252957
Blood thyroid stimulating hormone normal	28.93	13.69	8	36570	115	56255374
Parkinsonism	28.37	13.69	33	36545	9513	56245976
Drug withdrawal convulsions	28.34	13.69	15	36563	1347	56254142
Hypoventilation neonatal	28.20	13.69	6	36572	25	56255464
Injection site erythema	27.64	13.69	8	36570	77440	56178049
Neurological examination abnormal	27.55	13.69	9	36569	234	56255255
Psoriasis	27.33	13.69	13	36565	92679	56162810
Wrong patient	27.00	13.69	8	36570	149	56255340
Pruritus	26.99	13.69	110	36468	316513	55938976
Psychomotor skills impaired	26.95	13.69	17	36561	2123	56253366
Blood testosterone increased	26.75	13.69	8	36570	154	56255335
Neuropathy peripheral	26.61	13.69	17	36561	102876	56152613
Hepatitis	26.55	13.69	66	36512	35375	56220114
Victim of chemical submission	26.47	13.69	10	36568	402	56255087
COVID-19	26.33	13.69	8	36570	75050	56180439
Diarrhoea	25.44	13.69	279	36299	638228	55617261
Freezing phenomenon	25.24	13.69	13	36565	1104	56254385
Withdrawal syndrome	25.19	13.69	44	36534	18418	56237071
Disease progression	25.05	13.69	19	36559	105154	56150335
Antisocial behaviour	24.82	13.69	9	36569	322	56255167
Dyspnoea	24.78	13.69	256	36322	592321	55663168
Irritable bowel syndrome	24.56	13.69	7	36571	68451	56187038
Urticaria	24.48	13.69	35	36543	144641	56110848
Wrong rate	24.36	13.69	6	36572	53	56255436
Upper respiratory tract infection	24.29	13.69	8	36570	71280	56184209
Hypoaesthesia	24.16	13.69	34	36544	141457	56114032
Neurosensory hypoacusis	24.10	13.69	8	36570	219	56255270
Hallucination, synaesthetic	24.06	13.69	6	36572	56	56255433
Therapeutic response decreased	23.99	13.69	3	36575	52755	56202734
Antipsychotic drug level above therapeutic	23.63	13.69	12	36566	989	56254500
Stoma site erythema	23.29	13.69	12	36566	1020	56254469
Blood cholesterol increased	23.27	13.69	9	36569	72570	56182919
Chest pain	23.18	13.69	56	36522	189741	56065748
Vertigo	23.08	13.69	83	36495	54489	56201000
Impaired healing	22.94	13.69	14	36564	86827	56168662
Psychomotor retardation	22.83	13.69	19	36559	3650	56251839
Therapy non-responder	22.52	13.69	6	36572	61349	56194140
Sepsis	22.52	13.69	35	36543	139805	56115684
Medication error	21.99	13.69	69	36509	42266	56213223
Herpes zoster	21.83	13.69	11	36567	75878	56179611
Analgesic drug level above therapeutic	21.80	13.69	7	36571	172	56255317
Injury	21.69	13.69	6	36572	59845	56195644
Asthma	21.42	13.69	25	36553	112745	56142744
Delusion	21.18	13.69	31	36547	11184	56244305
Hypertonia	21.03	13.69	19	36559	4073	56251416
Medulloblastoma	20.96	13.69	5	36573	38	56255451
Pelvic fracture	20.56	13.69	32	36546	12181	56243308
Gamma-glutamyltransferase increased	20.40	13.69	55	36523	30950	56224539
Gastrointestinal disorder	20.34	13.69	26	36552	112676	56142813
Sudden death	20.23	13.69	28	36550	9597	56245892
Foetal growth restriction	20.20	13.69	24	36554	7075	56248414
Musculoskeletal pain	20.19	13.69	14	36564	81138	56174351
Bezoar	20.12	13.69	12	36566	1356	56254133
Feeling abnormal	20.06	13.69	35	36543	133567	56121922
Electrocardiogram QRS complex abnormal	19.96	13.69	7	36571	227	56255262
Distributive shock	19.87	13.69	11	36567	1080	56254409
Stoma site discharge	19.85	13.69	12	36566	1390	56254099
Apnoea	19.81	13.69	24	36554	7218	56248271
Therapeutic product effect incomplete	19.62	13.69	24	36554	106007	56149482
Adverse drug reaction	19.41	13.69	9	36569	65123	56190366
Needle track marks	19.35	13.69	4	36574	14	56255475
Cholinergic syndrome	19.34	13.69	8	36570	410	56255079
Hypercapnia	19.28	13.69	20	36558	5076	56250413
Flushing	18.94	13.69	11	36567	70089	56185400
Cardioactive drug level above therapeutic	18.86	13.69	6	36572	143	56255346
Retrograde amnesia	18.75	13.69	8	36570	443	56255046
Platelet count decreased	18.73	13.69	25	36553	106358	56149131
Salivary hypersecretion	18.70	13.69	23	36555	7027	56248462
Hospitalisation	18.57	13.69	13	36565	74987	56180502
Anal paraesthesia	18.20	13.69	4	36574	20	56255469
Genital paraesthesia	18.20	13.69	4	36574	20	56255469
Head discomfort	18.20	13.69	30	36548	11984	56243505
Galactorrhoea	17.91	13.69	17	36561	3878	56251611
Nightmare	17.84	13.69	36	36542	16790	56238699
Fibroma	17.64	13.69	9	36569	749	56254740
Product use issue	17.54	13.69	62	36516	185979	56069510
Adenocarcinoma metastatic	17.41	13.69	5	36573	83	56255406
Megacolon	17.41	13.69	12	36566	1739	56253750
Nausea	17.34	13.69	372	36206	763806	55491683
Foetal alcohol syndrome	17.32	13.69	4	36574	26	56255463
Palatal swelling	17.03	13.69	5	36573	90	56255399
Frontotemporal dementia	17.03	13.69	7	36571	353	56255136
Condition aggravated	16.95	13.69	143	36435	344755	55910734
Ill-defined disorder	16.82	13.69	12	36566	68531	56186958
Respiratory distress	16.80	13.69	52	36526	31615	56223874
Antipsychotic drug level increased	16.55	13.69	15	36563	3227	56252262
Poor quality sleep	16.51	13.69	36	36542	17719	56237770
Toxic epidermal necrolysis	16.45	13.69	41	36537	22001	56233488
Haematoma	16.45	13.69	52	36526	31967	56223522
Enanthema	16.33	13.69	7	36571	392	56255097
Lipohypertrophy	16.26	13.69	8	36570	616	56254873
Influenza	16.15	13.69	23	36555	95238	56160251
Hypopnoea	15.92	13.69	13	36565	2432	56253057
Influenza like illness	15.87	13.69	10	36568	60978	56194511
Concussion	15.87	13.69	23	36555	8223	56247266
Major depression	15.85	13.69	22	36556	7562	56247927
Subileus	15.78	13.69	14	36564	2930	56252559
Hyperkinesia	15.75	13.69	11	36567	1628	56253861
Product administration error	15.70	13.69	39	36539	20890	56234599
Dehydration	15.21	13.69	164	36414	158661	56096828
Thrombosis	15.12	13.69	10	36568	59417	56196072
Psychotic symptom	15.09	13.69	10	36568	1359	56254130
Hypovolaemic shock	15.02	13.69	18	36560	5355	56250134
Nasal congestion	15.01	13.69	9	36569	56361	56199128
Nephrolithiasis	15.00	13.69	3	36575	37332	56218157
Labelled drug-food interaction medication error	14.99	13.69	5	36573	139	56255350
Diarrhoea infectious	14.90	13.69	9	36569	1041	56254448
Drug level increased	14.90	13.69	38	36540	20687	56234802
Injection site reaction	14.89	13.69	8	36570	53239	56202250
Chondropathy	14.88	13.69	12	36566	2205	56253284
Musculoskeletal stiffness	14.69	13.69	52	36526	155955	56099534
Immobile	14.67	13.69	18	36560	5484	56250005
Mutism	14.67	13.69	10	36568	1423	56254066
Action tremor	14.64	13.69	6	36572	300	56255189
Adverse event	14.52	13.69	9	36569	55367	56200122
Adenocarcinoma gastric	14.50	13.69	7	36571	517	56254972
Oropharyngeal pain	14.43	13.69	20	36558	83768	56171721
Pneumothorax traumatic	14.38	13.69	5	36573	158	56255331
Amyotrophy	14.32	13.69	5	36573	160	56255329
Suspected counterfeit product	14.28	13.69	6	36572	320	56255169
Anterograde amnesia	14.26	13.69	7	36571	537	56254952
Maternal exposure during pregnancy	14.23	13.69	69	36509	189484	56066005
Urinary tract infection	14.04	13.69	95	36483	240418	56015071
Osteoarthritis	14.00	13.69	19	36559	80277	56175212
Rash maculo-papular	13.99	13.69	46	36532	28861	56226628
Rhinorrhoea	13.97	13.69	10	36568	57027	56198462
Blood glucose increased	13.91	13.69	17	36561	75134	56180355
Fluid retention	13.89	13.69	9	36569	54069	56201420
Subcutaneous haematoma	13.83	13.69	10	36568	1564	56253925
Liver injury	13.73	13.69	5	36573	41843	56213646

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	1022.03	15.85	940	22959	180547	31492898
Drug abuse	616.34	15.85	517	23382	87241	31586204
Coma	585.55	15.85	372	23527	40778	31632667
Poisoning deliberate	302.05	15.85	135	23764	7209	31666236
Miosis	264.00	15.85	129	23770	8441	31665004
Drug dependence	243.34	15.85	172	23727	22407	31651038
Asphyxia	240.58	15.85	107	23792	5644	31667801
Depressed level of consciousness	209.42	15.85	197	23702	38404	31635041
Drug use disorder	198.96	15.85	84	23815	3899	31669546
Overdose	197.31	15.85	279	23620	84385	31589060
Intentional overdose	194.08	15.85	195	23704	41194	31632251
Somnolence	190.62	15.85	299	23600	99146	31574299
Aggression	160.85	15.85	168	23731	37123	31636322
Suicide attempt	157.43	15.85	166	23733	37082	31636363
Logorrhoea	143.42	15.85	57	23842	2262	31671183
Altered state of consciousness	122.91	15.85	112	23787	20939	31652506
Substance abuse	114.87	15.85	70	23829	7088	31666357
Hepatocellular injury	113.02	15.85	108	23791	21436	31652009
Abnormal behaviour	105.65	15.85	109	23790	23719	31649726
Restlessness	96.67	15.85	103	23796	23258	31650187
Respiratory depression	94.22	15.85	82	23817	14428	31659017
Poisoning	89.03	15.85	69	23830	10322	31663123
Dysarthria	88.84	15.85	115	23784	31902	31641543
Confusional state	86.22	15.85	258	23641	133076	31540369
Agitation	83.63	15.85	148	23751	54021	31619424
Bezoar	76.61	15.85	28	23871	880	31672565
Alcohol abuse	74.17	15.85	45	23854	4519	31668926
Intentional product misuse	70.97	15.85	113	23786	37838	31635607
Bradykinesia	70.44	15.85	40	23859	3552	31669893
Intentional self-injury	70.29	15.85	67	23832	13248	31660197
Drug interaction	60.93	15.85	314	23585	208229	31465216
Bradyphrenia	60.42	15.85	39	23860	4365	31669080
Bradypnoea	59.96	15.85	32	23867	2515	31670930
Dystonic tremor	58.40	15.85	16	23883	189	31673256
Hypothermia	58.08	15.85	52	23847	9492	31663953
Housebound	56.03	15.85	16	23883	222	31673223
Hamartoma	55.84	15.85	12	23887	44	31673401
Disturbance in attention	55.14	15.85	76	23823	22374	31651071
Drug screen positive	55.05	15.85	35	23864	3817	31669628
Wrong patient received product	54.27	15.85	30	23869	2529	31670916
Mydriasis	52.86	15.85	42	23857	6510	31666935
Withdrawal syndrome	52.64	15.85	54	23845	11663	31661782
Pneumonia aspiration	52.41	15.85	100	23799	38626	31634819
Mania	50.00	15.85	47	23852	9130	31664315
Cardiac failure congestive	47.94	15.85	3	23896	79384	31594061
Product dose omission issue	45.00	15.85	12	23887	105574	31567871
Oesophageal obstruction	44.76	15.85	16	23883	471	31672974
Platelet count decreased	44.40	15.85	14	23885	110421	31563024
Homicide	44.36	15.85	19	23880	913	31672532
Bladder dilatation	43.50	15.85	21	23878	1335	31672110
Accidental overdose	41.91	15.85	60	23839	18290	31655155
Eosinophilic myocarditis	41.32	15.85	15	23884	462	31672983
Disorientation	41.11	15.85	79	23820	30665	31642780
Electrocardiogram QT prolonged	40.63	15.85	89	23810	37898	31635547
Respiratory acidosis	40.02	15.85	31	23868	4631	31668814
Melanoderma	38.43	15.85	11	23888	154	31673291
Hallucination, visual	38.08	15.85	53	23846	15741	31657704
Fatigue	37.30	15.85	129	23770	335077	31338368
Brain oedema	36.99	15.85	47	23852	12785	31660660
Accidental death	36.38	15.85	22	23877	2195	31671250
Respiratory distress	36.32	15.85	79	23820	33474	31639971
Tachycardia	35.37	15.85	132	23767	76075	31597370
Sedation	34.78	15.85	56	23843	18909	31654536
Nausea	34.59	15.85	118	23781	307829	31365616
Pain	34.26	15.85	55	23844	186704	31486741
Back pain	34.24	15.85	20	23879	109393	31564052
Arthralgia	33.40	15.85	39	23860	151385	31522060
Drug hypersensitivity	33.39	15.85	7	23892	72592	31600853
Victim of crime	33.11	15.85	12	23887	368	31673077
Hyper IgE syndrome	33.06	15.85	8	23891	55	31673390
Hyperthermia	32.64	15.85	39	23860	9965	31663480
Pulmonary oedema	31.44	15.85	89	23810	44413	31629032
Tardive dyskinesia	31.30	15.85	29	23870	5530	31667915
Behaviour disorder	31.14	15.85	26	23873	4321	31669124
Vasoplegia syndrome	30.72	15.85	18	23881	1695	31671750
Oesophageal haemorrhage	30.59	15.85	16	23883	1207	31672238
White blood cell count decreased	30.27	15.85	14	23885	87384	31586061
Rhabdomyolysis	30.22	15.85	111	23788	63470	31609975
Psychotic behaviour	29.88	15.85	13	23886	649	31672796
Neuroleptic malignant syndrome	29.84	15.85	49	23850	16820	31656625
Hepatic fibrosis	29.48	15.85	24	23875	3850	31669595
Status epilepticus	28.25	15.85	40	23859	12066	31661379
Cholestasis	28.23	15.85	60	23839	25015	31648430
Hyponatraemia	27.96	15.85	120	23779	73679	31599766
Mixed liver injury	27.95	15.85	19	23880	2318	31671127
Pain in extremity	27.75	15.85	28	23871	116175	31557270
Toxic epidermal necrolysis	27.12	15.85	51	23848	19473	31653972
Dyskinesia	27.06	15.85	53	23846	20857	31652588
Food aversion	26.59	15.85	10	23889	341	31673104
Peripheral swelling	26.57	15.85	9	23890	67856	31605589
Neuropathy peripheral	26.37	15.85	12	23887	75637	31597808
Extrapyramidal disorder	26.14	15.85	38	23861	11740	31661705
Substance use disorder	26.09	15.85	11	23888	508	31672937
Cholestatic liver injury	26.06	15.85	17	23882	1937	31671508
Psychotic disorder	25.86	15.85	54	23845	22239	31651206
Hypoosmolar state	25.84	15.85	7	23892	79	31673366
Sepsis	25.78	15.85	47	23852	151882	31521563
Cough	25.37	15.85	39	23860	134775	31538670
Atonic seizures	25.31	15.85	9	23890	261	31673184
Diarrhoea	25.30	15.85	159	23740	352250	31321195
Myoclonus	25.23	15.85	41	23858	13949	31659496
Muscle rigidity	25.04	15.85	34	23865	9863	31663582
Urticaria chronic	25.00	15.85	7	23892	90	31673355
Hyperdynamic left ventricle	24.97	15.85	8	23891	167	31673278
Plasma cell myeloma	24.89	15.85	6	23893	56525	31616920
Drug level increased	24.72	15.85	50	23849	20136	31653309
Drug ineffective	24.22	15.85	187	23712	395386	31278059
Rash	24.10	15.85	75	23824	201411	31472034
Cognitive disorder	23.97	15.85	56	23843	24867	31648578
Pleurothotonus	23.80	15.85	13	23886	1070	31672375
Urticaria	23.63	15.85	7	23892	57510	31615935
Consciousness fluctuating	23.49	15.85	13	23886	1098	31672347
Pulmonary congestion	23.35	15.85	38	23861	12945	31660500
Off label use	23.25	15.85	160	23739	347114	31326331
Acute myocardial infarction	23.16	15.85	5	23894	50818	31622627
Suicidal ideation	23.02	15.85	70	23829	36336	31637109
Metabolic acidosis	22.19	15.85	73	23826	39504	31633941
Chest pain	21.84	15.85	34	23865	116923	31556522
Fall	21.72	15.85	225	23674	185864	31487581
Pneumonia	21.70	15.85	156	23743	335156	31338289
Hepatitis acute	21.63	15.85	26	23873	6683	31666762
Thrombosis	21.50	15.85	4	23895	45147	31628298
Constipation	21.34	15.85	38	23861	123953	31549492
Reduced facial expression	20.99	15.85	11	23888	833	31672612
Dyspnoea	20.70	15.85	163	23736	343316	31330129
Hepatorenal syndrome	20.42	15.85	16	23883	2430	31671015
Analgesic drug level increased	20.33	15.85	10	23889	662	31672783
Disturbance in social behaviour	20.30	15.85	14	23885	1749	31671696
Disease progression	20.25	15.85	23	23876	90441	31583004
Coordination abnormal	20.02	15.85	26	23873	7225	31666220
Antasthmatic drug level	20.00	15.85	5	23894	40	31673405
Analgesic drug level	20.00	15.85	5	23894	40	31673405
Stomatitis	19.87	15.85	3	23896	39435	31634010
Emotional disorder	19.70	15.85	22	23877	5227	31668218
Loss of consciousness	19.46	15.85	112	23787	77243	31596202
Otospondylomegaepiphyseal dysplasia	19.41	15.85	6	23893	111	31673334
Blood disorder	19.33	15.85	17	23882	3029	31670416
Rheumatoid nodule	19.13	15.85	16	23883	2665	31670780
Apathy	19.09	15.85	24	23875	6458	31666987
Coagulation factor VII level decreased	19.02	15.85	6	23893	119	31673326
Fluid replacement	18.92	15.85	6	23893	121	31673324
Hepatic cytolysis	18.55	15.85	31	23868	10792	31662653
Pruritus	18.43	15.85	42	23857	125125	31548320
Neutrophil count decreased	18.42	15.85	6	23893	46388	31627057
Generalised onset non-motor seizure	18.34	15.85	4	23895	16	31673429
Congestive hepatopathy	18.14	15.85	13	23886	1726	31671719
Eye haematoma	17.95	15.85	5	23894	63	31673382
Patient uncooperative	17.80	15.85	8	23891	432	31673013
Cellulitis	17.72	15.85	7	23892	48011	31625434
Muscle contracture	17.64	15.85	11	23888	1159	31672286
Prescription form tampering	17.59	15.85	8	23891	444	31673001
Headache	17.57	15.85	75	23824	183577	31489868
Pyrexia	17.46	15.85	146	23753	303694	31369751
Hospitalisation	17.20	15.85	8	23891	49799	31623646
Colitis ischaemic	17.18	15.85	22	23877	6030	31667415
Thinking abnormal	17.00	15.85	21	23878	5552	31667893
Priapism	16.72	15.85	19	23880	4601	31668844
Psychomotor hyperactivity	16.18	15.85	26	23873	8761	31664684
Delirium	16.17	15.85	68	23831	41353	31632092
Atrial fibrillation	16.09	15.85	39	23860	113744	31559701
Therapy non-responder	16.08	15.85	3	23896	33808	31639637
Foetal growth restriction	16.08	15.85	17	23882	3798	31669647
Asthma	16.07	15.85	6	23893	42605	31630840
Vestibular disorder	16.03	15.85	10	23889	1055	31672390
Rheumatoid arthritis	16.02	15.85	8	23891	47801	31625644
Cerebrovascular accident	15.91	15.85	22	23877	79462	31593983
Spinal cord injury thoracic	15.90	15.85	5	23894	98	31673347

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	2115.63	13.19	1983	52805	380189	70493467
Coma	1290.12	13.19	831	53957	91013	70782643
Depressed level of consciousness	1017.52	13.19	704	54084	86727	70786929
Poisoning deliberate	884.97	13.19	372	54416	16688	70856968
Drug abuse	759.36	13.19	738	54050	146518	70727138
Sedation complication	754.80	13.19	310	54478	13100	70860556
Sedation	725.57	13.19	451	54337	46280	70827376
Orthostatic hypotension	695.64	13.19	456	54332	51287	70822369
Creatinine renal clearance decreased	677.40	13.19	309	54479	16891	70856765
Cognitive disorder	641.69	13.19	462	54326	60494	70813162
Intentional overdose	640.37	13.19	562	54226	97873	70775783
Blood calcium decreased	521.31	13.19	307	54481	28539	70845117
Somnolence	494.62	13.19	714	54074	214892	70658764
Fall	490.52	13.19	1066	53722	443030	70430626
Balance disorder	416.44	13.19	426	54362	89702	70783954
Suicide attempt	406.35	13.19	397	54391	79113	70794543
Miosis	396.19	13.19	201	54587	13900	70859756
Hypotension	376.54	13.19	908	53880	403473	70470183
Drug dependence	365.61	13.19	271	54517	37050	70836606
Overdose	365.58	13.19	546	54242	169199	70704457
Intentional self-injury	330.77	13.19	239	54549	31411	70842245
Asphyxia	324.75	13.19	159	54629	10183	70863473
Mobility decreased	275.94	13.19	368	54420	102631	70771025
Aggression	227.22	13.19	231	54557	48215	70825441
Drug use disorder	225.48	13.19	115	54673	8036	70865620
Hepatocellular injury	222.07	13.19	223	54565	45868	70827788
Hyponatraemia	219.24	13.19	421	54367	159666	70713990
Electrocardiogram QT prolonged	207.85	13.19	288	54500	83229	70790427
Confusional state	188.55	13.19	564	54224	283834	70589822
Respiratory depression	181.98	13.19	152	54636	24679	70848977
Drug interaction	179.68	13.19	674	54114	380767	70492889
Altered state of consciousness	170.00	13.19	181	54607	39841	70833815
Drug ineffective	158.95	13.19	304	54484	939448	69934208
Constipation	152.69	13.19	485	54303	251953	70621703
Rheumatoid arthritis	148.02	13.19	24	54764	291781	70581875
Poisoning	140.50	13.19	126	54662	22496	70851160
Pneumonia aspiration	139.02	13.19	204	54584	62085	70811571
Hypothermia	134.46	13.19	118	54670	20476	70853180
Wrong patient received product	126.21	13.19	64	54724	4416	70869240
Arthralgia	126.08	13.19	122	54666	503268	70370388
Abnormal behaviour	123.32	13.19	143	54645	34566	70839090
Intentional product misuse	119.64	13.19	218	54570	79377	70794279
Drug hypersensitivity	119.58	13.19	28	54760	262431	70611225
Logorrhoea	119.50	13.19	60	54728	4054	70869602
Substance abuse	118.33	13.19	81	54707	9756	70863900
Rash	115.27	13.19	135	54653	510427	70363229
Rhabdomyolysis	114.35	13.19	238	54550	95522	70778134
Restlessness	111.89	13.19	150	54638	41978	70831678
Cholestasis	111.49	13.19	160	54628	47712	70825944
Product dose omission issue	105.62	13.19	20	54768	217448	70656208
Bladder dilatation	103.35	13.19	43	54745	1874	70871782
Agitation	101.05	13.19	223	54565	93152	70780504
Disturbance in attention	100.82	13.19	144	54644	42750	70830906
Bradycardia	99.88	13.19	265	54523	124350	70749306
Peripheral swelling	98.74	13.19	30	54758	236533	70637123
Bradypnoea	98.28	13.19	58	54730	5401	70868255
Joint swelling	95.56	13.19	38	54750	253173	70620483
Hallucination, visual	91.30	13.19	113	54675	29224	70844432
Drug intolerance	89.98	13.19	31	54757	225656	70648000
Headache	89.09	13.19	198	54590	580207	70293449
Fatigue	88.73	13.19	333	54455	823986	70049670
Respiratory acidosis	86.00	13.19	68	54720	10213	70863443
Housebound	85.31	13.19	26	54762	446	70873210
Abdominal discomfort	84.69	13.19	30	54758	214628	70659028
Sinusitis	83.34	13.19	15	54773	169180	70704476
Bezoar	83.16	13.19	39	54749	2267	70871389
Treatment failure	82.37	13.19	8	54780	144134	70729522
Alcohol abuse	80.95	13.19	50	54738	5057	70868599
Arthropathy	76.79	13.19	12	54776	150045	70723611
Swelling	76.71	13.19	25	54763	188514	70685142
Mydriasis	75.65	13.19	77	54711	16076	70857580
Hyperthermia	75.41	13.19	78	54710	16593	70857063
Pain in extremity	74.74	13.19	86	54702	327996	70545660
Infusion related reaction	73.93	13.19	30	54758	197504	70676152
Cardiac failure congestive	73.64	13.19	9	54779	135448	70738208
Dysarthria	72.17	13.19	153	54635	62160	70811496
Back pain	69.76	13.19	64	54724	271088	70602568
Hypersensitivity	69.56	13.19	46	54742	229766	70643890
Cough	65.11	13.19	94	54694	325283	70548373
Lower respiratory tract infection	64.50	13.19	6	54782	111907	70761749
Therapeutic product effect decreased	63.64	13.19	16	54772	143002	70730654
Platelet count decreased	63.61	13.19	29	54759	178193	70695463
Disorientation	62.26	13.19	138	54650	57785	70815871
Lactic acidosis	62.25	13.19	148	54640	64876	70808780
Accidental overdose	61.60	13.19	103	54685	35018	70838638
Behaviour disorder	61.05	13.19	43	54745	5421	70868235
Akathisia	60.13	13.19	60	54728	12233	70861423
Systemic lupus erythematosus	59.98	13.19	5	54783	101897	70771759
Stomatitis	59.91	13.19	13	54775	128498	70745158
Apathy	59.87	13.19	59	54729	11849	70861807
Reduced facial expression	58.77	13.19	31	54757	2321	70871335
Off label use	58.58	13.19	336	54452	742724	70130932
Mixed liver injury	58.08	13.19	44	54744	6205	70867451
Dystonic tremor	58.01	13.19	16	54772	189	70873467
Loss of consciousness	57.82	13.19	256	54532	155460	70718196
Neuroleptic malignant syndrome	57.74	13.19	85	54703	25922	70847734
Inappropriate antidiuretic hormone secretion	57.44	13.19	80	54708	23196	70850460
Suicidal ideation	56.74	13.19	149	54639	69447	70804209
Acute kidney injury	56.37	13.19	587	54201	474037	70399619
White blood cell count decreased	55.74	13.19	31	54757	170110	70703546
Bradykinesia	55.11	13.19	46	54742	7456	70866200
Injection site pain	54.62	13.19	12	54776	117607	70756049
Glossodynia	54.53	13.19	3	54785	86484	70787172
Oxygen saturation decreased	53.96	13.19	205	54583	116224	70757432
Nasopharyngitis	53.04	13.19	56	54732	222150	70651506
Victim of sexual abuse	52.52	13.19	18	54770	455	70873201
Pneumonia	52.27	13.19	260	54528	595972	70277684
Extrapyramidal disorder	52.22	13.19	72	54716	20678	70852978
Pemphigus	51.99	13.19	3	54785	83033	70790623
Dyspnoea	51.57	13.19	366	54422	769694	70103962
Patient uncooperative	50.43	13.19	19	54769	635	70873021
Contraindicated product administered	49.45	13.19	21	54767	134591	70739065
Pyrexia	49.10	13.19	272	54516	606680	70266976
Diarrhoea	48.78	13.19	380	54408	782961	70090695
Prescription form tampering	48.27	13.19	16	54772	364	70873292
Infection	48.23	13.19	55	54733	210730	70662926
Sepsis	47.58	13.19	72	54716	244473	70629183
Drug screen positive	47.50	13.19	38	54750	5802	70867854
Nausea	47.35	13.19	426	54362	851662	70021994
Respiratory distress	45.56	13.19	118	54670	54532	70819124
Tachycardia	45.42	13.19	242	54546	158304	70715352
Disease progression	45.21	13.19	33	54755	156639	70717017
Hypokalaemia	45.20	13.19	211	54577	130977	70742679
Pericarditis	45.13	13.19	6	54782	84699	70788957
Chest pain	45.10	13.19	78	54710	251182	70622474
Withdrawal syndrome	44.96	13.19	74	54714	24830	70848826
Urticaria	44.94	13.19	36	54752	163013	70710643
Hand deformity	44.04	13.19	7	54781	86475	70787181
Benzodiazepine drug level increased	43.27	13.19	13	54775	212	70873444
Alopecia	43.06	13.19	54	54734	198436	70675220
Pruritus	41.44	13.19	133	54655	345427	70528229
Wheezing	41.00	13.19	11	54777	94159	70779497
Neuropathy peripheral	40.30	13.19	24	54764	126872	70746784
Prothrombin time ratio decreased	40.15	13.19	17	54771	774	70872882
Drug level above therapeutic	40.12	13.19	39	54749	7703	70865953
Therapy non-responder	39.68	13.19	6	54782	76909	70796747
Upper respiratory tract infection	39.08	13.19	7	54781	79267	70794389
Bradyphrenia	38.75	13.19	43	54745	9903	70863753
Wrong patient	38.53	13.19	13	54775	313	70873343
Victim of crime	38.40	13.19	14	54774	426	70873230
Urinary retention	38.36	13.19	108	54680	52412	70821244
Serotonin syndrome	38.31	13.19	94	54694	42020	70831636
Haemodynamic instability	37.42	13.19	53	54735	15605	70858051
Homicide	36.76	13.19	18	54770	1152	70872504
Delirium	36.75	13.19	134	54654	74480	70799176
COVID-19	36.50	13.19	18	54770	105739	70767917
Blister	36.41	13.19	16	54772	100510	70773146
Psychomotor skills impaired	35.11	13.19	28	54760	4256	70869400
Oesophageal obstruction	34.84	13.19	16	54772	886	70872770
Toxic epidermal necrolysis	34.62	13.19	87	54701	39470	70834186
Drug level increased	33.81	13.19	82	54706	36387	70837269
Cholestatic liver injury	33.64	13.19	27	54761	4141	70869515
Hypoaesthesia	33.15	13.19	42	54746	153697	70719959
Listless	32.92	13.19	25	54763	3538	70870118
Neutrophil count decreased	32.38	13.19	12	54776	83544	70790112
Pleurothotonus	32.10	13.19	21	54767	2345	70871311
Eosinophilic myocarditis	31.82	13.19	15	54773	882	70872774
Potentiating drug interaction	31.30	13.19	35	54753	8129	70865527
Encephalopathy	30.58	13.19	111	54677	61550	70812106
Asthma	30.45	13.19	29	54759	120764	70752892
Urinary tract infection	30.32	13.19	95	54693	248674	70624982
Mania	29.62	13.19	50	54738	17124	70856532
Delusion	29.41	13.19	53	54735	19112	70854544
Plasma cell myeloma	29.24	13.19	10	54778	73191	70800465
Injection site erythema	29.06	13.19	10	54778	72914	70800742
Melanoderma	28.96	13.19	11	54777	376	70873280
Thrombosis	28.93	13.19	11	54777	75394	70798262
Accidental death	28.78	13.19	24	54764	3884	70869772
Subileus	28.35	13.19	27	54761	5200	70868456
Psoriasis	28.04	13.19	21	54767	98412	70775244
Nasal congestion	27.97	13.19	8	54780	65664	70807992
Brain oedema	27.68	13.19	58	54730	23360	70850296
Blood thyroid stimulating hormone normal	27.43	13.19	8	54780	117	70873539
Weight increased	27.16	13.19	96	54692	242235	70631421
Hepatic enzyme increased	27.01	13.19	50	54738	156940	70716716
Flushing	26.86	13.19	15	54773	82157	70791499
Faecal vomiting	26.81	13.19	14	54774	1027	70872629
Influenza	26.72	13.19	29	54759	113671	70759985
Muscle rigidity	26.64	13.19	50	54738	18600	70855056
Hepatitis	26.52	13.19	92	54696	49888	70823768
Multiple drug therapy	26.45	13.19	21	54767	3171	70870485
Wound	25.72	13.19	23	54765	98709	70774947
Hospitalisation	25.67	13.19	16	54772	82552	70791104
Pulmonary oedema	25.21	13.19	128	54660	82150	70791506
Impaired healing	25.15	13.19	13	54775	74361	70799295
Therapeutic response decreased	25.12	13.19	7	54781	58446	70815210
Psychotic disorder	25.09	13.19	75	54713	37626	70836030
Gamma-glutamyltransferase increased	24.93	13.19	91	54697	50594	70823062
Hypoventilation	24.86	13.19	28	54760	6554	70867102
Vascular purpura	24.78	13.19	19	54769	2727	70870929
Feeling abnormal	24.78	13.19	45	54743	142274	70731382
Status epilepticus	24.75	13.19	57	54731	24469	70849187
Victim of homicide	24.69	13.19	8	54780	169	70873487
Hypoosmolar state	24.68	13.19	9	54779	274	70873382
Food aversion	24.66	13.19	12	54776	757	70872899
Mutism	24.45	13.19	17	54771	2099	70871557
Victim of chemical submission	24.43	13.19	10	54778	418	70873238
Oropharyngeal pain	24.42	13.19	23	54765	96287	70777369
Hepatic cytolysis	24.42	13.19	49	54739	19143	70854513
Drug withdrawal convulsions	24.22	13.19	17	54771	2131	70871525
Hypercapnia	24.19	13.19	31	54757	8298	70865358
Persecutory delusion	23.87	13.19	23	54765	4494	70869162
Metabolic acidosis	23.72	13.19	117	54671	74229	70799427
Drug withdrawal syndrome	23.62	13.19	67	54721	32648	70841008
Psychotic behaviour	23.51	13.19	13	54775	1069	70872587
Dry skin	23.48	13.19	7	54781	55924	70817732
Substance use disorder	23.20	13.19	11	54777	655	70873001
Hypocoagulable state	23.15	13.19	16	54772	1957	70871699
Fluid retention	23.09	13.19	10	54778	63375	70810281
Agranulocytosis	22.99	13.19	76	54712	40222	70833434
Hyperkalaemia	22.96	13.19	151	54637	106440	70767216
Hypereosinophilic syndrome	22.79	13.19	10	54778	497	70873159
Myocardial infarction	22.75	13.19	63	54725	171582	70702074
Cerebrovascular accident	22.70	13.19	48	54740	143422	70730234
Gastrointestinal disorder	22.52	13.19	29	54759	105398	70768258
Vasoplegia syndrome	22.45	13.19	19	54769	3137	70870519
Cellulitis	22.41	13.19	26	54762	98902	70774754
Wrong rate	22.40	13.19	6	54782	63	70873593
Hallucination, synaesthetic	22.14	13.19	6	54782	66	70873590
Abdominal distension	22.14	13.19	29	54759	104640	70769016
Myoclonus	22.06	13.19	57	54731	26298	70847358
Dyspnoea exertional	22.00	13.19	17	54771	78413	70795243
Hypertonia	21.79	13.19	26	54762	6472	70867184
Chills	21.62	13.19	50	54738	144736	70728920
Muscle spasms	21.58	13.19	55	54733	153991	70719665
Blood glucose increased	21.31	13.19	29	54759	102953	70770703
Prescription drug used without a prescription	21.24	13.19	18	54770	2979	70870677
Epilepsy	21.11	13.19	72	54716	38712	70834944
Erythema	21.08	13.19	81	54707	199482	70674174
Hypotonia	21.07	13.19	35	54753	11830	70861826
Tachyphrenia	20.98	13.19	15	54773	1936	70871720
Foreign body	20.93	13.19	17	54771	2651	70871005
Oesophageal haemorrhage	20.79	13.19	14	54774	1641	70872015
Antipsychotic drug level above therapeutic	20.79	13.19	15	54773	1964	70871692
Therapeutic product effect incomplete	20.78	13.19	38	54750	119844	70753812
Cytomegalovirus infection	20.74	13.19	3	54785	39755	70833901
Irritable bowel syndrome	20.22	13.19	7	54781	50843	70822813
Sudden death	20.21	13.19	48	54740	21016	70852640
Disturbance in social behaviour	20.17	13.19	20	54768	4047	70869609
Red blood cell sedimentation rate increased	19.96	13.19	3	54785	38639	70835017
Single umbilical artery	19.96	13.19	4	54784	9	70873647
Cataract	19.92	13.19	9	54779	55636	70818020
Antasthmatic drug level	19.88	13.19	5	54783	40	70873616
Malignant neoplasm progression	19.87	13.19	40	54748	121699	70751957
Dyskinesia	19.57	13.19	73	54715	41001	70832655
Injection site bruising	19.54	13.19	3	54785	38029	70835627
Analgesic drug level	19.46	13.19	5	54783	44	70873612
Neurological examination abnormal	19.29	13.19	9	54779	517	70873139
Hypovolaemic shock	19.29	13.19	32	54756	10805	70862851
Hepatic fibrosis	19.27	13.19	24	54764	6243	70867413
Coordination abnormal	19.23	13.19	40	54748	16026	70857630
Lung disorder	19.16	13.19	105	54683	69379	70804277
Distributive shock	19.15	13.19	15	54773	2222	70871434
Wrong technique in product usage process	19.13	13.19	15	54773	68683	70804973
Rhinorrhoea	19.11	13.19	14	54774	66357	70807299
Neurosensory hypoacusis	19.08	13.19	7	54781	217	70873439
Retrograde amnesia	18.94	13.19	9	54779	539	70873117
Hyperdynamic left ventricle	18.88	13.19	8	54780	365	70873291
Megacolon	18.46	13.19	17	54771	3139	70870517
Irritability	18.27	13.19	68	54720	38157	70835499
Poor feeding infant	18.04	13.19	6	54782	138	70873518
Psychotic symptom	18.01	13.19	15	54773	2423	70871233
Analgesic drug level increased	17.98	13.19	15	54773	2428	70871228
Decreased appetite	17.88	13.19	150	54638	304630	70569026
Throat irritation	17.65	13.19	3	54785	35301	70838355
Salivary hypersecretion	17.65	13.19	34	54754	12891	70860765
Galactorrhoea	17.47	13.19	17	54771	3361	70870295
Chronic kidney disease	17.42	13.19	13	54775	61044	70812612
Anal paraesthesia	17.35	13.19	4	54784	21	70873635
Influenza like illness	17.28	13.19	15	54773	65316	70808340
Hallucination	17.01	13.19	109	54679	76151	70797505
Asthenia	17.00	13.19	250	54538	457416	70416240
Antipsychotic drug level increased	16.99	13.19	21	54767	5419	70868237
Opiates positive	16.95	13.19	10	54778	930	70872726
Cardio-respiratory arrest	16.71	13.19	134	54654	100543	70773113
Hyper IgE syndrome	16.68	13.19	8	54780	489	70873167
Full blood count abnormal	16.68	13.19	3	54785	33875	70839781
Acute myocardial infarction	16.67	13.19	19	54769	72868	70800788
Haematocrit decreased	16.58	13.19	12	54776	57246	70816410
Abdominal pain upper	16.56	13.19	85	54703	193517	70680139
Atopic keratoconjunctivitis	16.50	13.19	4	54784	27	70873629
Accidental poisoning	16.45	13.19	12	54776	1598	70872058
Injection site reaction	16.43	13.19	9	54779	49843	70823813
Priapism	16.41	13.19	18	54770	4092	70869564
On and off phenomenon	16.28	13.19	15	54773	2771	70870885
Major depression	16.18	13.19	26	54762	8548	70865108
Atonic seizures	16.11	13.19	9	54779	755	70872901
Rash pruritic	16.02	13.19	15	54773	62976	70810680
Fluid replacement	16.00	13.19	6	54782	198	70873458
Coronary artery disease	15.88	13.19	15	54773	62721	70810935
Hepatitis acute	15.83	13.19	34	54754	13928	70859728
Herpes zoster	15.70	13.19	26	54762	85209	70788447
Drug resistance	15.63	13.19	5	54783	38185	70835471
Colitis ischaemic	15.54	13.19	34	54754	14103	70859553
Eosinophilia	15.48	13.19	67	54721	40252	70833404
Coagulation factor VII level decreased	15.45	13.19	6	54782	218	70873438
Consciousness fluctuating	15.40	13.19	12	54776	1764	70871892
Antisocial behaviour	15.39	13.19	8	54780	581	70873075
Subcutaneous haematoma	15.29	13.19	14	54774	2565	70871091
Fibromyalgia	15.27	13.19	9	54779	47865	70825791
Fungal infection	15.17	13.19	5	54783	37462	70836194
Weight decreased	15.13	13.19	160	54628	310328	70563328
Red blood cell count decreased	15.02	13.19	11	54777	52150	70821506
Psychomotor retardation	14.96	13.19	20	54768	5578	70868078
Respiratory alkalosis	14.87	13.19	17	54771	4044	70869612
Theft	14.86	13.19	6	54782	242	70873414
Action tremor	14.81	13.19	7	54781	414	70873242
Parkinsonism	14.79	13.19	35	54753	15290	70858366
Eye haematoma	14.75	13.19	5	54783	122	70873534
Cardioactive drug level above therapeutic	14.74	13.19	6	54782	247	70873409
Medulloblastoma	14.72	13.19	5	54783	123	70873533
Spinal cord injury thoracic	14.72	13.19	5	54783	123	70873533
Haematochezia	14.70	13.19	21	54767	73060	70800596
Drug diversion	14.67	13.19	10	54778	1196	70872460
Psychomotor hyperactivity	14.62	13.19	35	54753	15398	70858258
Product administration error	14.51	13.19	53	54735	29470	70844186
Adverse drug reaction	14.41	13.19	12	54776	53332	70820324
Gastrointestinal haemorrhage	14.36	13.19	56	54732	137352	70736304
Genital paraesthesia	14.30	13.19	4	54784	50	70873606
Anterograde amnesia	14.29	13.19	8	54780	674	70872982
Vertigo	14.25	13.19	90	54698	62553	70811103
Osteoarthritis	14.24	13.19	22	54766	74125	70799531
Myalgia	14.20	13.19	74	54714	167818	70705838
Contusion	14.15	13.19	51	54737	127985	70745671
Myelosuppression	14.14	13.19	3	54785	30142	70843514
High-pitched crying	14.11	13.19	3	54785	10	70873646
Chest discomfort	14.10	13.19	49	54739	124332	70749324
Foetal alcohol syndrome	14.08	13.19	4	54784	53	70873603
Adenocarcinoma metastatic	14.07	13.19	5	54783	141	70873515
Analgesic drug level above therapeutic	14.02	13.19	7	54781	467	70873189
Wrong product administered	13.99	13.19	24	54764	8327	70865329
Pulmonary congestion	13.95	13.19	47	54741	25107	70848549
Mental status changes	13.84	13.19	17	54771	63084	70810572
Loss of personal independence in daily activities	13.77	13.19	28	54760	84882	70788774
Hypopnoea	13.71	13.19	15	54773	3400	70870256
Arthritis	13.71	13.19	35	54753	97945	70775711
Tongue neoplasm malignant stage unspecified	13.69	13.19	9	54779	1014	70872642
Palatal swelling	13.63	13.19	5	54783	155	70873501
Hepatorenal syndrome	13.54	13.19	16	54772	3941	70869715
Oedema peripheral	13.48	13.19	112	54676	227979	70645677
Pelvic fracture	13.44	13.19	28	54760	11233	70862423
Urticaria chronic	13.35	13.19	7	54781	518	70873138
Migraine	13.33	13.19	22	54766	72216	70801440
Blood pressure increased	13.33	13.19	88	54700	188429	70685227

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05BA04	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives
FDA CS	M0002356	Benzodiazepines
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018682	GABA Agents
MeSH PA	D018757	GABA Modulators
MeSH PA	D006993	Hypnotics and Sedatives
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents
CHEBI has role	CHEBI:35474	anti-anxiety agents
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:78298	environmental contaminants
FDA EPC	N0000175694	Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Alcohol withdrawal delirium	indication	8635005
Anxiety	indication	48694002
Suicidal thoughts	contraindication	6471006
Disorder of lung	contraindication	19829001	DOID:850
Borderline personality disorder	contraindication	20010003	DOID:10930
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Depressive disorder	contraindication	35489007
Low blood pressure	contraindication	45007003
Substance abuse	contraindication	66214007
Psychotic disorder	contraindication	69322001
Sleep apnea	contraindication	73430006	DOID:0050847
Decreased respiratory function	contraindication	80954004
Kidney disease	contraindication	90708001	DOID:557
Hypoalbuminemia	contraindication	119247004
Disease of liver	contraindication	235856003	DOID:409
Sleep automatism	contraindication	247962006
Syncope	contraindication	271594007
Pregnancy, function	contraindication	289908002
Coma	contraindication	371632003
Porphyria	contraindication	418470004
Behavioral Disorders	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.41	acidic
pKa2	11.87	acidic
pKa3	1.83	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor alpha-1/beta-3/gamma-2	Ion channel	P14867 P18507 P28472	GBRA1_HUMAN GBRG2_HUMAN GBRB3_HUMAN	POSITIVE ALLOSTERIC MODULATOR	IC50	7.75		WOMBAT-PK	CHEMBL

External reference:

ID	Source
4018020	VUID
N0000146364	NUI
D00464	KEGG_DRUG
4018020	VANDF
C0029997	UMLSCUI
CHEBI:7823	CHEBI
CHEMBL568	ChEMBL_ID
DB00842	DRUGBANK_ID
D010076	MESH_DESCRIPTOR_UI
4616	PUBCHEM_CID
7253	IUPHAR_LIGAND_ID
1507	INN_ID
6GOW6DWN2A	UNII
7781	RXNORM
4493	MMSL
5211	MMSL
d00040	MMSL
001462	NDDF
387455006	SNOMEDCT_US
79225003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2067	CAPSULE, GELATIN COATED	10 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2067	CAPSULE, GELATIN COATED	10 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2069	CAPSULE, GELATIN COATED	15 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2069	CAPSULE, GELATIN COATED	15 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2073	CAPSULE, GELATIN COATED	30 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2073	CAPSULE, GELATIN COATED	30 mg	ORAL	ANDA	21 sections
OXAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-304	CAPSULE	15 mg	ORAL	ANDA	13 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	43353-074	CAPSULE, GELATIN COATED	30 mg	ORAL	ANDA	19 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	43353-965	CAPSULE	10 mg	ORAL	ANDA	20 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	43353-980	CAPSULE	30 mg	ORAL	ANDA	20 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	52817-290	CAPSULE	10 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	52817-291	CAPSULE	15 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	52817-292	CAPSULE	30 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	62584-812	CAPSULE, GELATIN COATED	10 mg	ORAL	ANDA	25 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	62584-812	CAPSULE, GELATIN COATED	10 mg	ORAL	ANDA	25 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	62584-813	CAPSULE, GELATIN COATED	15 mg	ORAL	ANDA	25 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	62584-813	CAPSULE, GELATIN COATED	15 mg	ORAL	ANDA	25 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	62584-814	CAPSULE, GELATIN COATED	30 mg	ORAL	ANDA	25 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	62584-814	CAPSULE, GELATIN COATED	30 mg	ORAL	ANDA	25 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	67544-117	CAPSULE, GELATIN COATED	10 mg	ORAL	ANDA	19 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	67544-268	CAPSULE, GELATIN COATED	15 mg	ORAL	ANDA	19 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	71610-639	CAPSULE	15 mg	ORAL	ANDA	21 sections