minaprine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1812 25905-77-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • minaprine
  • mineprine
  • minaprine hydrochloride
  • minaprine dihydrochloride
  • minaprine HCl
  • Agr 1240
  • 30038CM
Agr 1240 refers to di-HCl; short-acting type A MAO inhibitor (MAOI) of mild potency; structure
  • Molecular weight: 298.39
  • Formula: C17H22N4O
  • CLOGP: 2.99
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 50.28
  • ALOGS: -3.63
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,ITK,MAPK10,MAPK7,MARK4,NTRK2,PDK4,PRKDC,SIK2,SIK3,STK33,TTK 24
kinase-selectivity-class BRAF,CAMK2D,FLT3,MAP3K21,MAPK7,MARK4,SIK2,SIK3,STK33,TTK 10
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AX07 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:38323 cholinergic drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
CHEBI has role CHEBI:51039 dopamine uptake inhibitor

Related Drugs by ATC class:

N06AX Other antidepressants 28 drugs
agomelatinebifemelanebrexanolonebupropiondesvenlafaxinedextromethorphanduloxetineesketaminegepironelevomilnacipranmedifoxaminemianserin show all 28 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.08 Basic
pKa2 4.32 Basic
pKa3 0.81 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR Ki 4.77 CHEMBL
Acetylcholinesterase Enzyme IC50 4.07 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR IC50 4.77 CHEMBL
Acetylcholinesterase Enzyme IC50 4.07 CHEMBL

External reference:

IDSource
D05039 KEGG_DRUG
C0066561 UMLSCUI
CHEBI:51038 CHEBI
CHEMBL278819 ChEMBL_ID
DB00805 DRUGBANK_ID
C006149 MESH_SUPPLEMENTAL_RECORD_UI
4199 PUBCHEM_CID
3503 INN_ID
25953-17-7 SECONDARY_CAS_RN
00U7GX0NLM UNII
236400 RXNORM
005843 NDDF
005844 NDDF
CHEMBL1364551 ChEMBL_ID
00U7GX0NLM INXIGHT DRUGS

Pharmaceutical products:

None