medazepam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 1654 2898-12-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • medazepam
  • mezapam
  • medazepam hydrochloride
  • medazepam HCl
A benzodiazepine derivative used in the treatment of anxiety. It has sedative, muscle relaxant, and anticonvulsant properties. One of its metabolites is DIAZEPAM and one of its excretion products is OXAZEPAM.
  • Molecular weight: 270.76
  • Formula: C16H15ClN2
  • CLOGP: 4.12
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 15.60
  • ALOGS: -4.33
  • ROTB: 1

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BA03 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.59 Basic
pKa2 4.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel Ki 6.28 CHEMBL

External reference:

IDSource
N0000166925 NUI
C0025051 UMLSCUI
D01292 KEGG_DRUG
387192003 SNOMEDCT_US
35967000 SNOMEDCT_US
6680 RXNORM
004101 NDDF
CHEBI:31807 CHEBI
CHEMBL28333 ChEMBL_ID
ETM878JC9K UNII
2898-11-5 SECONDARY_CAS_RN
2517 INN_ID
4041 PUBCHEM_CID
D008472 MESH_DESCRIPTOR_UI
DB13437 DRUGBANK_ID
CHEMBL2106842 ChEMBL_ID

Pharmaceutical products:

None