indobufen Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
non-steroidal anti-inflammatory agents, arylbutanoic acid derivatives 1439 63610-08-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • indobufen
  • ibustrin
  • K 3920
  • K-3920
thromboxane A2 antagonist
  • Molecular weight: 295.34
  • Formula: C18H17NO3
  • CLOGP: 3.27
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 57.61
  • ALOGS: -3.58
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 13 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.35 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 85 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1984 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AC10 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006401 Hematologic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.11 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme WOMBAT-PK
Prostaglandin G/H synthase 2 Enzyme WOMBAT-PK

External reference:

IDSource
C0063479 UMLSCUI
D07141 KEGG_DRUG
6T9949G4LZ UNII
4398 INN_ID
27518 RXNORM
006129 NDDF
717166005 SNOMEDCT_US
CHEBI:135239 CHEBI
107641 PUBCHEM_CID
DB12545 DRUGBANK_ID
CHEMBL1765292 ChEMBL_ID
C020371 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None