glisoxepide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 1305 25046-79-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glisoxepide
  • glisepin
  • glisoxepid
oral sulfonylurea hypoglycemic agent which stimulates insulin secretion; minor descriptor (75-85); on-line & Index Medicus search SULFONYLUREA COMPOUNDS (75-85); RN given refers to parent cpd
  • Molecular weight: 449.53
  • Formula: C20H27N5O5S
  • CLOGP: 0.75
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 3
  • TPSA: 133.64
  • ALOGS: -3.64
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BB11 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.97 acidic
pKa2 10.56 acidic
pKa3 11.14 acidic
pKa4 3.54 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 7.96 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D07118 KEGG_DRUG
C0061330 UMLSCUI
CHEBI:135731 CHEBI
CHEMBL2106618 ChEMBL_ID
DB01289 DRUGBANK_ID
C100171 MESH_SUPPLEMENTAL_RECORD_UI
2923 INN_ID
H7SC0I332I UNII
32778 PUBCHEM_CID
006891 NDDF

Pharmaceutical products:

None