glisoxepide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 1305 25046-79-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glisoxepide
  • glisepin
  • glisoxepid
oral sulfonylurea hypoglycemic agent which stimulates insulin secretion; minor descriptor (75-85); on-line & Index Medicus search SULFONYLUREA COMPOUNDS (75-85); RN given refers to parent cpd
  • Molecular weight: 449.53
  • Formula: C20H27N5O5S
  • CLOGP: 0.71
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 3
  • TPSA: 133.64
  • ALOGS: -3.64
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BB11 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.97 acidic
pKa2 10.56 acidic
pKa3 11.14 acidic
pKa4 3.54 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 7.96 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D07118 KEGG_DRUG
C0061330 UMLSCUI
CHEBI:135731 CHEBI
CHEMBL2106618 ChEMBL_ID
DB01289 DRUGBANK_ID
C100171 MESH_SUPPLEMENTAL_RECORD_UI
2923 INN_ID
H7SC0I332I UNII
32778 PUBCHEM_CID
006891 NDDF

Pharmaceutical products:

None