acetohexamide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 57 968-81-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dymelor
  • acetohexamide
  • acetohexamid
A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide.
  • Molecular weight: 324.40
  • Formula: C15H20N2O4S
  • CLOGP: 2.25
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 92.34
  • ALOGS: -3.83
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.50 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3.43 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 77.06 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Dec. 23, 1964 FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BB31 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
MeSH PA D007004 Hypoglycemic Agents
CHEBI has role CHEBI:35526 hypoglycemic drug
CHEBI has role CHEBI:90415 insulin secretagogues

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Ki 4.64 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
QGC8W08I6I UNII
4017503 VUID
N0000145888 NUI
D00219 KEGG_DRUG
C0000992 UMLSCUI
CHEBI:28052 CHEBI
CHEMBL1589 ChEMBL_ID
1989 PUBCHEM_CID
DB00414 DRUGBANK_ID
D000092 MESH_DESCRIPTOR_UI
1134 INN_ID
6793 IUPHAR_LIGAND_ID
173 RXNORM
4123 MMSL
522 MMSL
873 MMSL
d00162 MMSL
000907 NDDF
387210001 SNOMEDCT_US
39064002 SNOMEDCT_US
4017503 VANDF

Pharmaceutical products:

None