carbutamide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 505 339-43-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carbutamide
  • nadisan
  • nadizan
  • norboral
  • aminophenurobutane
  • bucarban
  • burcol
  • butisulfina
  • carbutamid
  • glybutamide
  • sulfaninylbutylurea
  • butylcarbamide
A sulfonylurea antidiabetic agent with similar actions and uses to CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
  • Molecular weight: 271.34
  • Formula: C11H17N3O3S
  • CLOGP: 1.02
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 101.29
  • ALOGS: -2.60
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.75 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BB06 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
MeSH PA D007004 Hypoglycemic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.31 acidic
pKa2 1.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 4.60 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
N0000166471 NUI
D02425 KEGG_DRUG
C0007080 UMLSCUI
CHEBI:135118 CHEBI
CHEMBL448570 ChEMBL_ID
DB13406 DRUGBANK_ID
D002271 MESH_DESCRIPTOR_UI
9564 PUBCHEM_CID
615 INN_ID
E3K8P4869P UNII
2068 RXNORM
005300 NDDF

Pharmaceutical products:

None