gliclazide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 1299 21187-98-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gliclazide
  • diabezidum
  • diabrezide
  • diabyl
  • diaprel
  • glimicron
  • glinormax
  • glyzide
  • gliclazid
  • dizalid
  • S 1702
An oral sulfonylurea hypoglycemic agent which stimulates insulin secretion.
  • Molecular weight: 323.41
  • Formula: C15H21N3O3S
  • CLOGP: 1.09
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 78.51
  • ALOGS: -3.23
  • ROTB: 2

Drug dosage:

DoseUnitRoute
60 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.13 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 97 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.43 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.41 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.03 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 16.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1972 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lactic acidosis 712.01 12.14 360 26434 33549 46625719
Hypoglycaemia 507.57 12.14 341 26453 54008 46605260
Acute kidney injury 467.92 12.14 623 26171 235232 46424036
Diabetes mellitus inadequate control 235.94 12.14 126 26668 13088 46646180
Diabetic ketoacidosis 234.06 12.14 140 26654 18070 46641198
Hyperglycaemia 163.72 12.14 146 26648 34925 46624343
Metabolic acidosis 145.54 12.14 143 26651 38637 46620631
Hypoglycaemic coma 141.86 12.14 54 26740 2520 46656748
Hyperkalaemia 137.02 12.14 157 26637 50552 46608716
Glycosylated haemoglobin increased 112.84 12.14 73 26721 10803 46648465
Diabetic metabolic decompensation 111.57 12.14 37 26757 1148 46658120
Pemphigoid 84.31 12.14 48 26746 5643 46653625
Euglycaemic diabetic ketoacidosis 78.75 12.14 33 26761 1983 46657285
Hyperlactacidaemia 75.76 12.14 33 26761 2182 46657086
Completed suicide 64.77 12.14 5 26789 145915 46513353
Gangrene 62.65 12.14 37 26757 4658 46654610
Diabetes mellitus 62.53 12.14 107 26687 49958 46609310
Pancreatic carcinoma 60.71 12.14 41 26753 6516 46652752
Pancreatitis acute 60.47 12.14 73 26721 24799 46634469
Blood glucose increased 57.04 12.14 127 26667 71886 46587382
Drug interaction 56.89 12.14 249 26545 202845 46456423
Tubulointerstitial nephritis 56.31 12.14 55 26739 14733 46644535
Product dose omission issue 55.79 12.14 14 26780 168506 46490762
Death 55.13 12.14 67 26727 335481 46323787
Ketoacidosis 54.96 12.14 32 26762 3923 46655345
Arterial occlusive disease 54.19 12.14 34 26760 4770 46654498
Hyponatraemia 53.32 12.14 153 26641 101179 46558089
Bradycardia 50.36 12.14 115 26679 66183 46593085
Urine output decreased 49.38 12.14 45 26749 11052 46648216
Angina pectoris 48.56 12.14 68 26726 26707 46632561
Drug hypersensitivity 46.37 12.14 43 26751 243782 46415486
Acne 41.31 12.14 54 26740 19865 46639403
Renal impairment 39.79 12.14 113 26681 74259 46585009
Malaise 38.12 12.14 322 26472 330910 46328358
Infected dermal cyst 37.81 12.14 13 26781 451 46658817
Treatment failure 36.62 12.14 5 26789 93082 46566186
Vomiting 34.97 12.14 405 26389 452389 46206879
Pain 33.79 12.14 150 26644 476798 46182470
Pneumonia aspiration 32.38 12.14 62 26732 31543 46627725
Circulatory collapse 32.11 12.14 50 26744 21574 46637694
Transplant dysfunction 31.25 12.14 24 26770 4658 46654610
Drug ineffective 31.13 12.14 245 26549 677593 45981675
Blood lactic acid 30.04 12.14 8 26786 113 46659155
Coma 29.60 12.14 87 26707 58262 46601006
Acetonaemia 28.15 12.14 7 26787 74 46659194
Faeces discoloured 28.03 12.14 41 26753 16746 46642522
Melaena 26.65 12.14 53 26741 27719 46631549
Head injury 26.06 12.14 49 26745 24587 46634681
Autoimmune nephritis 26.05 12.14 9 26785 317 46658951
Metastases to fallopian tube 25.63 12.14 6 26788 48 46659220
Abdominal discomfort 24.96 12.14 30 26764 151135 46508133
Gastric disorder 24.47 12.14 50 26744 26655 46632613
Exposure during pregnancy 24.45 12.14 16 26778 108196 46551072
Anaphylactic reaction 23.95 12.14 76 26718 53036 46606232
Haemoglobin increased 23.15 12.14 16 26778 2639 46656629
Bladder sphincter atony 23.13 12.14 7 26787 160 46659108
Blood glucose fluctuation 22.86 12.14 19 26775 4127 46655141
Arthropathy 22.83 12.14 10 26784 84690 46574578
Butterfly rash 22.34 12.14 11 26783 963 46658305
Poisoning deliberate 22.16 12.14 25 26769 7901 46651367
Periorbital oedema 21.59 12.14 20 26774 5015 46654253
Fear-related avoidance of activities 21.44 12.14 6 26788 103 46659165
Blood pressure increased 21.33 12.14 135 26659 126531 46532737
Anuria 20.67 12.14 29 26765 11402 46647866
Steatorrhoea 20.64 12.14 8 26786 392 46658876
Trichophytosis 20.54 12.14 5 26789 48 46659220
Blood glucose decreased 20.51 12.14 38 26756 18854 46640414
Insomnia 20.26 12.14 40 26754 164884 46494384
Serum serotonin increased 20.22 12.14 6 26788 128 46659140
Inappropriate antidiuretic hormone secretion 20.09 12.14 32 26762 14070 46645198
Multiple drug therapy 20.04 12.14 10 26784 901 46658367
Blood phosphorus increased 20.03 12.14 15 26779 2804 46656464
Blood pressure inadequately controlled 19.86 12.14 18 26776 4388 46654880
Glucose urine present 19.74 12.14 9 26785 663 46658605
Cardiac failure 19.34 12.14 94 26700 79854 46579414
Hypovolaemic shock 19.21 12.14 19 26775 5164 46654104
Confusional state 19.16 12.14 157 26637 159735 46499533
Cardiac arrest 18.88 12.14 102 26692 90297 46568971
Metastases to bladder 18.78 12.14 6 26788 165 46659103
Glomerular filtration rate decreased 18.72 12.14 28 26766 11666 46647602
Haematemesis 18.66 12.14 47 26747 28759 46630509
Hepatic steatosis 18.57 12.14 42 26752 24000 46635268
Crystal arthropathy 17.51 12.14 6 26788 206 46659062
Exercise tolerance decreased 17.38 12.14 17 26777 4560 46654708
Diabetic ulcer 17.27 12.14 6 26788 215 46659053
Blood creatinine increased 17.19 12.14 88 26706 76315 46582953
Loss of employment 17.02 12.14 10 26784 1246 46658022
Liver function test abnormal 16.98 12.14 62 26732 46425 46612843
Transplant rejection 16.84 12.14 24 26770 9572 46649696
Endometrial cancer stage I 16.81 12.14 6 26788 233 46659035
Carcinoid crisis 16.54 12.14 6 26788 244 46659024
Diabetic hyperosmolar coma 16.36 12.14 7 26787 443 46658825
Hypersensitivity 16.35 12.14 39 26755 150282 46508986
Nephrotic syndrome 16.34 12.14 17 26777 4904 46654364
Unresponsive to stimuli 16.34 12.14 48 26746 32126 46627142
Depression 16.32 12.14 47 26747 170057 46489211
Fatigue 16.22 12.14 249 26545 608448 46050820
Plasma cell myeloma 16.11 12.14 3 26791 44475 46614793
Adverse drug reaction 16.05 12.14 3 26791 44359 46614909
Blood ketone body increased 15.88 12.14 6 26788 274 46658994
International normalised ratio increased 15.86 12.14 61 26733 46822 46612446
Hepatic pain 15.84 12.14 13 26781 2775 46656493
Salivary hypersecretion 15.80 12.14 19 26775 6426 46652842
Radius fracture 15.75 12.14 14 26780 3328 46655940
Muscle neoplasm 15.62 12.14 4 26790 48 46659220
Carcinoid tumour 15.60 12.14 6 26788 288 46658980
Urine calcium/creatinine ratio increased 15.56 12.14 5 26789 140 46659128
Stomatitis 15.55 12.14 10 26784 68287 46590981
Endometrial hyperplasia 15.48 12.14 8 26786 776 46658492
Gallbladder neoplasm 15.40 12.14 4 26790 51 46659217
Lymphatic system neoplasm 15.26 12.14 4 26790 53 46659215
Hepatitis cholestatic 15.26 12.14 19 26775 6658 46652610
Disease progression 15.19 12.14 18 26776 91282 46567986
Abdominal adhesions 15.02 12.14 13 26781 2984 46656284
Necrotising myositis 14.82 12.14 6 26788 330 46658938
Atrioventricular block complete 14.77 12.14 20 26774 7607 46651661
Cardioactive drug level increased 14.72 12.14 11 26783 2048 46657220
Blood pressure systolic increased 14.67 12.14 43 26751 28744 46630524
Metastases to ovary 14.60 12.14 6 26788 343 46658925
Pyrexia 14.59 12.14 129 26665 348673 46310595
Cataract 14.48 12.14 58 26736 45357 46613911
Blood lactic acid increased 14.40 12.14 17 26777 5640 46653628
Diabetic ketosis 14.37 12.14 5 26789 180 46659088
Body height increased 14.22 12.14 4 26790 70 46659198
Therapeutic product effect decreased 14.05 12.14 16 26778 82585 46576683
Bite 14.05 12.14 6 26788 378 46658890
Needle issue 14.04 12.14 17 26777 5787 46653481
Injection site swelling 14.02 12.14 3 26791 40324 46618944
Rash 13.99 12.14 134 26660 356378 46302890
Feeling abnormal 13.96 12.14 32 26762 125028 46534240
Renal abscess 13.89 12.14 7 26787 644 46658624
Insulin-like growth factor decreased 13.88 12.14 6 26788 389 46658879
Hepatic enzyme increased 13.74 12.14 16 26778 81771 46577497
Injection site pruritus 13.73 12.14 3 26791 39740 46619528
Blood glucose abnormal 13.69 12.14 18 26776 6654 46652614
Electrocardiogram T wave peaked 13.68 12.14 5 26789 208 46659060
Headache 13.65 12.14 193 26601 478159 46181109
Bronchitis 13.62 12.14 25 26769 105954 46553314
Lichen planus 13.57 12.14 10 26784 1823 46657445
Off label use 13.57 12.14 146 26648 379695 46279573
Hypotension 13.24 12.14 197 26597 232392 46426876
Peripheral venous disease 13.23 12.14 14 26780 4118 46655150
Frequent bowel movements 13.20 12.14 25 26769 12607 46646661
Unevaluable event 13.17 12.14 5 26789 46170 46613098
Injection site erythema 13.11 12.14 14 26780 74413 46584855
Neuropathy peripheral 13.01 12.14 20 26774 90873 46568395
Pneumonia cytomegaloviral 12.98 12.14 10 26784 1950 46657318
Language disorder 12.86 12.14 9 26785 1514 46657754
Granulomatous dermatitis 12.84 12.14 4 26790 101 46659167
Medication error 12.82 12.14 43 26751 30868 46628400
Papule 12.78 12.14 14 26780 4281 46654987
Duodenal ulcer 12.59 12.14 18 26776 7200 46652068
Hypomenorrhoea 12.47 12.14 6 26788 499 46658769
Alveolar lung disease 12.35 12.14 4 26790 115 46659153
Urine ketone body present 12.19 12.14 10 26784 2132 46657136
Hyperglycaemic hyperosmolar nonketotic syndrome 12.19 12.14 6 26788 525 46658743

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 464.93 11.95 387 28304 50594 29873193
Acute kidney injury 324.96 11.95 769 27922 273073 29650714
Lactic acidosis 309.53 11.95 249 28442 30964 29892823
Diabetes mellitus inadequate control 298.10 11.95 173 28518 12589 29911198
Diabetic ketoacidosis 203.36 11.95 148 28543 15838 29907949
Hyperkalaemia 161.67 11.95 253 28438 65757 29858030
Metabolic acidosis 124.44 11.95 166 28525 37295 29886492
Hyperglycaemia 101.91 11.95 146 28545 35054 29888733
Hyperlactacidaemia 93.49 11.95 47 28644 2559 29921228
Diabetic metabolic decompensation 81.85 11.95 35 28656 1311 29922476
Death 76.92 11.95 141 28550 357142 29566645
Completed suicide 72.85 11.95 6 28685 99486 29824301
Type 2 diabetes mellitus 69.28 11.95 75 28616 13547 29910240
Glycosylated haemoglobin increased 62.36 11.95 60 28631 9431 29914356
Pancreatitis acute 55.32 11.95 93 28598 25602 29898185
Pemphigoid 54.06 11.95 50 28641 7478 29916309
Blood glucose increased 53.97 11.95 155 28536 61375 29862412
Euglycaemic diabetic ketoacidosis 50.77 11.95 28 28663 1843 29921944
Obesity 48.65 11.95 50 28641 8505 29915282
Obstructive pancreatitis 44.14 11.95 16 28675 383 29923404
Product dose omission issue 42.95 11.95 17 28674 91614 29832173
Drug abuse 42.30 11.95 13 28678 82059 29841728
Hepatojugular reflux 38.39 11.95 14 28677 341 29923446
Low density lipoprotein abnormal 37.91 11.95 13 28678 263 29923524
Lower respiratory tract infection 36.83 11.95 80 28611 26634 29897153
Foetal disorder 36.38 11.95 16 28675 642 29923145
Pancreatic carcinoma 36.13 11.95 41 28650 7796 29915991
Dermatitis bullous 35.30 11.95 36 28655 6068 29917719
Drug interaction 35.28 11.95 318 28373 199250 29724537
Right ventricular dysfunction 34.63 11.95 17 28674 879 29922908
Diabetes mellitus 34.33 11.95 103 28588 41762 29882025
Fibrillary glomerulonephritis 33.16 11.95 8 28683 41 29923746
Herbal interaction 31.41 11.95 12 28679 334 29923453
Malaise 29.97 11.95 267 28424 166695 29757092
Weight increased 29.56 11.95 146 28545 74767 29849020
Neutropenia neonatal 29.41 11.95 13 28678 528 29923259
Urinary tract discomfort 29.17 11.95 8 28683 73 29923714
Cholestasis 29.16 11.95 70 28621 24880 29898907
Mouth swelling 27.89 11.95 18 28673 1581 29922206
Hemiparaesthesia 27.15 11.95 7 28684 49 29923738
Spleen congestion 26.97 11.95 11 28680 365 29923422
Exercise tolerance decreased 26.75 11.95 25 28666 3787 29920000
Febrile neutropenia 26.68 11.95 38 28653 106655 29817132
Plasma cell myeloma 26.59 11.95 9 28682 53453 29870334
Hypoglycaemic coma 26.09 11.95 20 28671 2311 29921476
Dust allergy 25.87 11.95 11 28680 406 29923381
Wrong patient received product 25.80 11.95 18 28673 1799 29921988
Food aversion 25.56 11.95 10 28681 297 29923490
Skin ulcer 25.47 11.95 56 28635 18793 29904994
Dental caries 25.38 11.95 26 28665 4405 29919382
Mental status changes 25.12 11.95 3 28688 37076 29886711
Ketonuria 24.97 11.95 12 28679 592 29923195
Jaundice cholestatic 24.80 11.95 26 28665 4525 29919262
Antipsychotic drug level increased 24.63 11.95 22 28669 3144 29920643
Renal impairment 24.45 11.95 151 28540 84033 29839754
Pyonephrosis 24.34 11.95 7 28684 77 29923710
Hypoosmolar state 24.34 11.95 7 28684 77 29923710
Vomiting projectile 24.29 11.95 12 28679 629 29923158
Distributive shock 24.20 11.95 12 28679 634 29923153
Acetonaemia 23.49 11.95 7 28684 88 29923699
Cardiac failure 23.21 11.95 148 28543 83270 29840517
Cardiac ventricular disorder 22.33 11.95 8 28683 185 29923602
Intercapillary glomerulosclerosis 22.25 11.95 6 28685 51 29923736
Drug ineffective 22.16 11.95 214 28477 340173 29583614
White blood cell count decreased 21.88 11.95 29 28662 83918 29839869
Pain 20.72 11.95 90 28601 172551 29751236
Suspected suicide attempt 20.44 11.95 7 28684 141 29923646
Metastases to pelvis 19.95 11.95 8 28683 254 29923533
Bladder cancer 19.65 11.95 33 28658 9069 29914718
Thrombosis 19.51 11.95 8 28683 42223 29881564
Thrombocytosis 19.50 11.95 20 28671 3393 29920394
Fatigue 19.45 11.95 205 28486 320468 29603319
Autoimmune pancreatitis 19.43 11.95 8 28683 272 29923515
Liver function test abnormal 18.96 11.95 69 28622 30881 29892906
Bone marrow failure 18.79 11.95 3 28688 29782 29894005
Intentional product misuse 18.75 11.95 5 28686 34662 29889125
Off label use 18.72 11.95 151 28540 249139 29674648
Tonic clonic movements 18.72 11.95 12 28679 1042 29922745
Jaundice 18.71 11.95 71 28620 32415 29891372
Microalbuminuria 18.64 11.95 10 28681 623 29923164
Disease progression 18.46 11.95 30 28661 79844 29843943
Platelet count decreased 18.45 11.95 47 28644 106082 29817705
Unevaluable event 18.34 11.95 4 28687 31781 29892006
Cockroach allergy 18.00 11.95 5 28686 48 29923739
Anion gap increased 17.89 11.95 14 28677 1667 29922120
Application site haematoma 17.82 11.95 5 28686 50 29923737
Flour sensitivity 17.82 11.95 5 28686 50 29923737
Neuromyopathy 17.10 11.95 11 28680 961 29922826
Generalised oedema 16.84 11.95 36 28655 11849 29911938
Forced vital capacity decreased 16.79 11.95 10 28681 762 29923025
Pancreatic carcinoma metastatic 16.72 11.95 18 28673 3229 29920558
Orbital oedema 16.61 11.95 6 28685 142 29923645
Diabetic eye disease 16.56 11.95 5 28686 66 29923721
Oedema peripheral 16.33 11.95 164 28527 105668 29818119
Capillary fragility 16.29 11.95 5 28686 70 29923717
White blood cell count increased 16.12 11.95 78 28613 39595 29884192
Mast cell degranulation present 16.09 11.95 5 28686 73 29923714
Neutrophilia 16.00 11.95 18 28673 3389 29920398
Pancreatitis 15.74 11.95 73 28618 36417 29887370
Deep vein thrombosis 15.66 11.95 21 28670 60480 29863307
Lipase increased 15.56 11.95 29 28662 8647 29915140
Hospitalisation 15.31 11.95 12 28679 44307 29879480
Diabetic retinopathy 15.31 11.95 13 28678 1737 29922050
Headache 15.30 11.95 107 28584 182199 29741588
Conjunctival disorder 15.28 11.95 5 28686 87 29923700
Pyrexia 15.22 11.95 195 28496 294294 29629493
Staphylococcal infection 15.18 11.95 5 28686 30219 29893568
Nocturia 15.18 11.95 28 28663 8284 29915503
Bladder papilloma 15.16 11.95 4 28687 31 29923756
Lip swelling 15.15 11.95 36 28655 12708 29911079
Cardiac failure chronic 15.05 11.95 23 28668 5840 29917947
Depression 14.99 11.95 41 28650 90396 29833391
Essential hypertension 14.98 11.95 15 28676 2473 29921314
Blood glucose fluctuation 14.95 11.95 18 28673 3643 29920144
Hepatocellular injury 14.94 11.95 56 28635 25415 29898372
Thrombocytopenia 14.91 11.95 74 28617 136970 29786817
Left ventricular failure 14.86 11.95 21 28670 4970 29918817
Hypovitaminosis 14.80 11.95 8 28683 506 29923281
Pancreatic neoplasm 14.80 11.95 10 28681 949 29922838
Gastric dilatation 14.73 11.95 8 28683 511 29923276
Palindromic rheumatism 14.71 11.95 6 28685 199 29923588
Ketoacidosis 14.62 11.95 18 28673 3728 29920059
Weight decreased 14.59 11.95 214 28477 150707 29773080
Hypohidrosis 14.52 11.95 6 28685 206 29923581
Acidosis 14.36 11.95 31 28660 10270 29913517
Vitamin D deficiency 14.30 11.95 21 28670 5149 29918638
Left ventricular dysfunction 14.29 11.95 28 28663 8663 29915124
Sopor 14.11 11.95 32 28659 10959 29912828
Seizure 13.94 11.95 48 28643 98427 29825360
Procedural haemorrhage 13.90 11.95 14 28677 2324 29921463
Cytomegalovirus infection 13.62 11.95 3 28688 23671 29900116
Blood pressure increased 13.37 11.95 116 28575 71812 29851975
Melaena 13.34 11.95 64 28627 32373 29891414
Bronchitis viral 13.30 11.95 6 28685 256 29923531
Lipid metabolism disorder 13.30 11.95 6 28685 256 29923531
Adverse drug reaction 13.18 11.95 3 28688 23142 29900645
Blood pressure systolic increased 13.16 11.95 38 28653 15072 29908715
Therapy non-responder 12.93 11.95 6 28685 29447 29894340
Muscle oedema 12.93 11.95 5 28686 144 29923643
Traumatic shock 12.85 11.95 3 28688 13 29923774
Peak expiratory flow rate decreased 12.83 11.95 5 28686 147 29923640
Restlessness 12.72 11.95 3 28688 22596 29901191
Diabetic nephropathy 12.62 11.95 12 28679 1857 29921930
Vasculitic rash 12.60 11.95 9 28682 934 29922853
Toxicity to various agents 12.52 11.95 109 28582 177074 29746713
Urogenital infection fungal 12.49 11.95 3 28688 15 29923772
Cardiogenic shock 12.44 11.95 40 28651 16821 29906966
Face oedema 12.39 11.95 31 28660 11303 29912484
Glomerular filtration rate decreased 12.34 11.95 31 28660 11331 29912456
Hyperglycaemic hyperosmolar nonketotic syndrome 12.33 11.95 9 28682 965 29922822
Urine ketone body present 12.29 11.95 9 28682 970 29922817
Faecal calprotectin abnormal 12.17 11.95 5 28686 169 29923618
Leukopenia 12.14 11.95 22 28669 56137 29867650
Febrile bone marrow aplasia 12.02 11.95 25 28666 8072 29915715

Pharmacologic Action:

SourceCodeDescription
ATC A10BB09 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
MeSH PA D007004 Hypoglycemic Agents
CHEBI has role CHEBI:35526 hypoglycemic drug
CHEBI has role CHEBI:48578 free-radical scavenger
CHEBI has role CHEBI:90415 insulin secretagogues

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.97 acidic
pKa2 3.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 6.22 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sulfonylurea receptor 2, Kir6.2 Ion channel BLOCKER Ki 5.13 WOMBAT-PK

External reference:

IDSource
N0000166470 NUI
D01599 KEGG_DRUG
C1567616 UMLSCUI
CHEBI:31654 CHEBI
GCZ PDB_CHEM_ID
CHEMBL427216 ChEMBL_ID
DB01120 DRUGBANK_ID
D005907 MESH_DESCRIPTOR_UI
3056 INN_ID
G4PX8C4HKV UNII
3475 PUBCHEM_CID
4816 RXNORM
003858 NDDF
325238000 SNOMEDCT_US
395731001 SNOMEDCT_US

Pharmaceutical products:

None