glibornuride Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 1298 26944-48-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glibornurid
  • glibornuride
  • gluboride
  • Ro-6-4563
was MH 1975-92 (see under SULFONYLUREA COMPOUNDS 1975-90); use SULFONYLUREA COMPOUNDS to search GLIBORNURIDE 1975-92; an oral, sulfonylurea hypoglycemic agent which stimulates insulin secretion
  • Molecular weight: 366.48
  • Formula: C18H26N2O4S
  • CLOGP: 3.70
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 95.50
  • ALOGS: -3.76
  • ROTB: 2

Drug dosage:

DoseUnitRoute
38 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.20 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.92 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.27 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.34 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1969 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BB04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
MeSH PA D007004 Hypoglycemic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.65 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 7.05 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sulfonylurea receptor 2, Kir6.2 Ion channel BLOCKER Ki 5.17 WOMBAT-PK

External reference:

IDSource
D02427 KEGG_DRUG
C0038766 UMLSCUI
CHEBI:135545 CHEBI
CHEMBL529888 ChEMBL_ID
DB08962 DRUGBANK_ID
C073323 MESH_SUPPLEMENTAL_RECORD_UI
2751 INN_ID
VP83E7434R UNII
12818200 PUBCHEM_CID
102846 RXNORM
005328 NDDF
325235002 SNOMEDCT_US
419384001 SNOMEDCT_US

Pharmaceutical products:

None