glimepiride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 1300 93479-97-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glimepiride
  • diameprid
  • glimax
  • glimperide
  • glirid
  • Molecular weight: 490.62
  • Formula: C24H34N4O5S
  • CLOGP: 3.96
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 124.68
  • ALOGS: -4.11
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.23 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.19 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.522 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.512 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 91.833 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 9.977 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 0.830 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 1.210 % High 1
herg hERG pIC50 4.824 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 18.281 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 73.621 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 0.360 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK 17
kinase-selectivity-class AXL,CDK9,EIF2AK3,GRK2,MAP2K6,MAPK7,PDK1,STK33,TEK 9
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 8.260 High 1
mh-clint Mouse hepatocyte intrinsic clearance 45.186 High 1
mppb Mouse plasma protein binding (% unbound) 0.440 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 35.400 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 0.900 % High 1
rh-clint Rat hepatocyte intrinsic clearance 35.975 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 36.050 % High 1
rppb Rat plasma protein binding (% unbound) 0.240 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 55.081 uM High 1

Approvals:

DateAgencyCompanyOrphan
Nov. 30, 1995 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 2080.72 12.24 848 35520 69000 90523079
Lactic acidosis 604.20 12.24 327 36041 50136 90541943
Blood glucose increased 438.19 12.24 338 36030 94908 90497171
Hypoglycaemic coma 388.37 12.24 110 36258 2880 90589199
Acute kidney injury 259.06 12.24 462 35906 319925 90272154
Glycosylated haemoglobin increased 253.01 12.24 124 36244 15438 90576641
Diabetes mellitus inadequate control 248.59 12.24 130 36238 18554 90573525
Hypoglycaemic encephalopathy 204.42 12.24 43 36325 298 90591781
Diabetic ketoacidosis 165.99 12.24 110 36258 24297 90567782
Blood glucose decreased 153.09 12.24 103 36265 23326 90568753
Euglycaemic diabetic ketoacidosis 143.12 12.24 63 36305 6138 90585941
Hyperglycaemia 136.63 12.24 133 36235 50837 90541242
Systemic lupus erythematosus 120.37 12.24 6 36362 361890 90230189
Infusion related reaction 111.69 12.24 17 36351 416763 90175316
Glossodynia 108.08 12.24 5 36363 321774 90270305
Synovitis 102.09 12.24 8 36360 329744 90262335
Diabetic metabolic decompensation 98.70 12.24 35 36333 1922 90590157
Maternal exposure during pregnancy 98.05 12.24 14 36354 360049 90232030
Dehydration 95.89 12.24 229 36139 194218 90397861
Hyperkalaemia 92.47 12.24 122 36246 64842 90527237
Metabolic acidosis 91 12.24 112 36256 55564 90536515
Renal failure 84.64 12.24 172 36196 130835 90461244
Contraindicated product administered 83.62 12.24 14 36354 320125 90271954
Eosinophilic myocarditis 83.55 12.24 24 36344 661 90591418
Drug intolerance 82.87 12.24 38 36330 447553 90144526
Joint swelling 79.72 12.24 52 36316 503248 90088831
Helicobacter infection 77.90 12.24 3 36365 226847 90365232
Cerebral infarction 76.17 12.24 72 36296 26524 90565555
Diarrhoea 74.08 12.24 635 35733 938555 89653524
Exposure during pregnancy 67.93 12.24 8 36360 238402 90353677
Sopor 67.32 12.24 65 36303 24579 90567500
Pancreatitis acute 66.54 12.24 73 36295 32042 90560037
Wound 65.63 12.24 20 36348 302960 90289119
Therapeutic product effect decreased 64.46 12.24 16 36352 277555 90314524
Ketoacidosis 63.39 12.24 35 36333 5560 90586519
MELAS syndrome 62.39 12.24 15 36353 201 90591878
Renal impairment 60.62 12.24 132 36236 105289 90486790
Hypersensitivity 60.53 12.24 56 36312 454621 90137458
Fall 60.04 12.24 364 36004 481446 90110633
Drug interaction 58.71 12.24 243 36125 276210 90315869
Diabetes mellitus 58.01 12.24 98 36270 64777 90527302
Drug ineffective 57.03 12.24 325 36043 1383973 89208106
Loss of consciousness 56.43 12.24 153 36215 140085 90451994
Drug level increased 55.60 12.24 62 36306 27700 90564379
Blood glucose fluctuation 55.41 12.24 31 36337 5052 90587027
Swelling 54.15 12.24 53 36315 419005 90173074
Ill-defined disorder 53.17 12.24 6 36362 184885 90407194
Alopecia 52.80 12.24 73 36295 494998 90097081
Off label use 52.53 12.24 246 36122 1102006 89490073
Irritable bowel syndrome 52.13 12.24 10 36358 207438 90384641
Injury 50.69 12.24 9 36359 197340 90394739
Rheumatoid arthritis 50.24 12.24 43 36325 362571 90229508
Liver injury 47.89 12.24 6 36362 170561 90421518
Discomfort 46.66 12.24 26 36342 274309 90317770
Pancreatitis 46.65 12.24 93 36275 69733 90522346
Blood glucose abnormal 46.45 12.24 35 36333 9457 90582622
Arthropathy 45.39 12.24 48 36320 366194 90225885
Mobility decreased 45.26 12.24 22 36346 250712 90341367
Fibromyalgia 43.96 12.24 14 36354 206255 90385824
Pancreatic carcinoma 43.48 12.24 32 36336 8345 90583734
Altered state of consciousness 42.99 12.24 58 36310 31474 90560605
Psoriatic arthropathy 42.81 12.24 19 36349 228316 90363763
Dermatitis exfoliative 42.67 12.24 27 36341 5509 90586570
Cold sweat 42.01 12.24 39 36329 14042 90578037
Impaired healing 41.58 12.24 21 36347 234178 90357901
Musculoskeletal stiffness 40.05 12.24 36 36332 296496 90295583
Hyperglycaemic hyperosmolar nonketotic syndrome 38.50 12.24 16 36352 1353 90590726
Hepatic enzyme increased 37.62 12.24 54 36314 360682 90231397
Postprandial hypoglycaemia 37.62 12.24 9 36359 118 90591961
Urinary tract infection 37.42 12.24 230 36138 305402 90286677
Hyperhidrosis 36.46 12.24 129 36239 136176 90455903
Bursitis 36.07 12.24 5 36363 131649 90460430
Anaemia 35.63 12.24 253 36115 352549 90239530
Neuroglycopenia 34.66 12.24 14 36354 1101 90590978
Hypothermia 33.30 12.24 36 36332 15539 90576540
Wheezing 33.24 12.24 28 36340 238052 90354027
Treatment failure 33.19 12.24 44 36324 303884 90288195
Abdominal discomfort 32.96 12.24 91 36277 477237 90114842
Nasopharyngitis 32.49 12.24 72 36296 407032 90185047
Blood creatinine increased 32.49 12.24 102 36266 101284 90490795
Hyperinsulinaemia 31.29 12.24 8 36360 140 90591939
Anuria 31.24 12.24 34 36334 14784 90577295
Asthenia 31.06 12.24 339 36029 533412 90058667
Oliguria 30.87 12.24 29 36339 10595 90581484
Glomerular filtration rate decreased 30.83 12.24 36 36332 16896 90575183
Myocardial infarction 30.69 12.24 103 36265 105869 90486210
Hyperthyroidism 30.17 12.24 37 36331 18273 90573806
Electrolyte imbalance 29.85 12.24 42 36326 23703 90568376
Decreased appetite 29.70 12.24 255 36113 376285 90215794
Intentional product use issue 29.67 12.24 26 36342 216866 90375213
Nausea 29.50 12.24 616 35752 1109700 89482379
Hypoparathyroidism 29.17 12.24 12 36356 989 90591090
Cholecystitis 29.00 12.24 35 36333 17005 90575074
Vascular access site haemorrhage 28.82 12.24 8 36360 194 90591885
C-reactive protein abnormal 28.32 12.24 8 36360 127421 90464658
Restlessness 28.08 12.24 51 36317 35669 90556410
Glomerulonephritis minimal lesion 28.04 12.24 9 36359 363 90591716
Product use issue 27.44 12.24 57 36311 329862 90262217
Hyponatraemia 27.23 12.24 116 36252 133422 90458657
Sinusitis 27.10 12.24 61 36307 343027 90249052
Cholelithiasis 27.10 12.24 63 36305 52443 90539636
Biopsy skin abnormal 27.03 12.24 7 36361 129 90591950
Night sweats 26.97 12.24 9 36359 128757 90463322
Cardiac arrest 26.93 12.24 98 36270 104837 90487242
Pyelonephritis acute 26.51 12.24 20 36348 5412 90586667
Glycosylated haemoglobin abnormal 26.50 12.24 8 36360 263 90591816
Anaemia vitamin B12 deficiency 26.40 12.24 10 36358 662 90591417
Urine ketone body present 26.29 12.24 15 36353 2537 90589542
Embolic cerebellar infarction 26.07 12.24 5 36363 20 90592059
Stomatitis 25.88 12.24 44 36324 274654 90317425
Migraine 25.83 12.24 23 36345 190369 90401710
Potentiating drug interaction 25.78 12.24 20 36348 5642 90586437
Blood insulin increased 25.65 12.24 7 36361 159 90591920
Sleep disorder 25.60 12.24 25 36343 198005 90394074
Drug hypersensitivity 25.33 12.24 98 36270 463511 90128568
Musculoskeletal pain 25.33 12.24 19 36349 171232 90420847
Poverty of speech 24.99 12.24 8 36360 320 90591759
Inflammation 24.92 12.24 21 36347 178571 90413508
Contusion 24.83 12.24 39 36329 251177 90340902
Insulin C-peptide increased 24.71 12.24 6 36362 84 90591995
Gastroenteritis 24.61 12.24 43 36325 29186 90562893
Ketosis 24.60 12.24 10 36358 799 90591280
Cardiac failure congestive 24.35 12.24 91 36277 98603 90493476
Product use in unapproved indication 24.02 12.24 63 36305 336173 90255906
Disorientation 23.95 12.24 54 36314 44060 90548019
Blood cholesterol increased 23.85 12.24 29 36339 207983 90384096
Pulmonary fibrosis 23.43 12.24 7 36361 107496 90484583
Wound infection 23.06 12.24 7 36361 106395 90485684
Injection site nodule 23.02 12.24 17 36351 4456 90587623
Differential white blood cell count abnormal 22.77 12.24 10 36358 968 90591111
Osteoarthritis 22.75 12.24 27 36341 195703 90396376
Bradypnoea 22.40 12.24 17 36351 4641 90587438
Urogenital haemorrhage 22.36 12.24 7 36361 260 90591819
Erythema multiforme 22.24 12.24 26 36342 12220 90579859
Blood potassium increased 22.17 12.24 34 36334 20715 90571364
Pain 22.12 12.24 275 36093 996066 89596013
Atrial fibrillation 21.99 12.24 109 36259 133502 90458577
Pancreatitis necrotising 21.89 12.24 13 36355 2368 90589711
Ballismus 21.79 12.24 6 36362 141 90591938
Rhabdomyolysis 21.69 12.24 57 36311 51199 90540880
Type 2 diabetes mellitus 21.59 12.24 30 36338 203214 90388865
Coronary artery disease 21.52 12.24 44 36324 33579 90558500
Tachypnoea 21.49 12.24 34 36334 21275 90570804
Infection 21.44 12.24 74 36294 362020 90230059
Bladder cancer 21.15 12.24 18 36350 5783 90586296
Unresponsive to stimuli 21.07 12.24 47 36321 38074 90554005
Weight decreased 21.01 12.24 239 36129 379671 90212408
Autoimmune disorder 20.82 12.24 3 36365 76741 90515338
Hyporesponsive to stimuli 20.79 12.24 11 36357 1606 90590473
Diabetic retinopathy 20.38 12.24 13 36355 2689 90589390
Renal arteriosclerosis 20.36 12.24 6 36362 181 90591898
Product dose omission issue 20.15 12.24 192 36176 291495 90300584
Coagulation test abnormal 19.65 12.24 9 36359 962 90591117
Diabetic complication 19.63 12.24 9 36359 964 90591115
Lower limb fracture 19.53 12.24 5 36363 85008 90507071
Pancreatic carcinoma metastatic 19.29 12.24 12 36356 2376 90589703
Mixed anxiety and depressive disorder 19.05 12.24 7 36361 426 90591653
Hypotension 19.03 12.24 207 36161 325190 90266889
Toxic epidermal necrolysis 18.99 12.24 41 36327 32487 90559592
Nervousness 18.83 12.24 42 36326 34014 90558065
Metabolic encephalopathy 18.80 12.24 18 36350 6734 90585345
Bradycardia 18.79 12.24 75 36293 83772 90508307
Blood urea increased 18.52 12.24 39 36329 30374 90561705
Hip arthroplasty 18.46 12.24 4 36364 76204 90515875
Diabetic neuropathy 18.35 12.24 15 36353 4559 90587520
Azotaemia 18.29 12.24 16 36352 5332 90586747
Somnolence 18.28 12.24 145 36223 208939 90383140
Hypertriglyceridaemia 18.22 12.24 19 36349 7870 90584209
Hypoglycaemic unconsciousness 17.91 12.24 8 36360 806 90591273
Ventricular fibrillation 17.89 12.24 25 36343 14019 90578060
Colon cancer 17.85 12.24 22 36346 10922 90581157
Gastrointestinal disorder 17.64 12.24 49 36319 256638 90335441
Carotid arteriosclerosis 17.56 12.24 9 36359 1231 90590848
Muscle discomfort 17.55 12.24 6 36362 295 90591784
Chronic kidney disease 17.48 12.24 52 36316 50139 90541940
Cardiac failure 17.08 12.24 88 36280 109408 90482671
Hyperventilation 16.98 12.24 17 36351 6711 90585368
Therapy non-responder 16.82 12.24 18 36350 136686 90455393
Blood triglycerides increased 16.79 12.24 24 36344 13737 90578342
Continuous haemodiafiltration 16.79 12.24 8 36360 935 90591144
Embolic cerebral infarction 16.75 12.24 7 36361 600 90591479
Gastrointestinal haemorrhage 16.57 12.24 76 36292 90172 90501907
Hypomagnesaemia 16.53 12.24 41 36327 35547 90556532
Hypercholesterolaemia 16.52 12.24 10 36358 100882 90491197
Arthralgia 16.46 12.24 217 36151 778305 89813774
Ectopic ACTH syndrome 16.31 12.24 5 36363 173 90591906
Hypophagia 16.27 12.24 41 36327 35896 90556183
Nephritis 16.12 12.24 12 36356 3183 90588896
Pemphigoid 16.12 12.24 19 36349 9007 90583072
Rash 16.07 12.24 224 36144 795876 89796203
Phobia 16.07 12.24 6 36362 382 90591697
Retinopathy proliferative 15.98 12.24 4 36364 64 90592015
Intentional overdose 15.76 12.24 77 36291 93757 90498322
Condition aggravated 15.69 12.24 158 36210 595387 89996692
Peripheral venous disease 15.69 12.24 7 36361 83914 90508165
Head injury 15.63 12.24 37 36331 31151 90560928
Prescribed overdose 15.53 12.24 10 36358 97615 90494464
Vision blurred 15.41 12.24 86 36282 110207 90481872
Capillary leak syndrome 15.34 12.24 11 36357 2756 90589323
Ophthalmic herpes zoster 15.26 12.24 11 36357 2777 90589302
Cardiovascular insufficiency 15.23 12.24 9 36359 1626 90590453
Reperfusion injury 15.14 12.24 4 36364 80 90591999
Syncope 15.07 12.24 98 36270 132565 90459514
Lung disorder 15.06 12.24 23 36345 149860 90442219
Metabolic alkalosis 15.00 12.24 12 36356 3537 90588542
Dysarthria 14.93 12.24 52 36316 54430 90537649
Colitis ulcerative 14.93 12.24 3 36365 60263 90531816
Compartment syndrome 14.83 12.24 11 36357 2901 90589178
Cerebral reperfusion injury 14.78 12.24 3 36365 17 90592062
Asthma 14.66 12.24 49 36319 242111 90349968
Pylorus dilatation 14.63 12.24 3 36365 18 90592061
Idiopathic CD4 lymphocytopenia 14.63 12.24 3 36365 18 90592061
Thrombotic cerebral infarction 14.63 12.24 5 36363 246 90591833
Toxicity to various agents 14.54 12.24 178 36190 287668 90304411
Intestinal angioedema 14.51 12.24 7 36361 841 90591238
Acute respiratory failure 14.50 12.24 44 36324 42874 90549205
Polyuria 14.50 12.24 19 36349 10021 90582058
Glomerulosclerosis 14.36 12.24 6 36362 514 90591565
Mental status changes 14.35 12.24 45 36323 44634 90547445
Gait inability 14.21 12.24 23 36345 146433 90445646
Pulmonary hilar enlargement 14.14 12.24 4 36364 104 90591975
Aspiration pleural cavity 14.00 12.24 7 36361 909 90591170
Lipomatosis 13.97 12.24 4 36364 109 90591970
Glucose urine present 13.94 12.24 7 36361 917 90591162
Hypoglycaemic seizure 13.93 12.24 6 36362 554 90591525
Haemorrhagic stroke 13.86 12.24 15 36353 6481 90585598
Tremor 13.81 12.24 107 36261 153066 90439013
Shock hypoglycaemic 13.79 12.24 4 36364 114 90591965
Sepsis 13.74 12.24 121 36247 179693 90412386
Dizziness 13.67 12.24 321 36047 588963 90003116
Leukocytosis 13.66 12.24 35 36333 30955 90561124
Ischaemic cerebral infarction 13.27 12.24 8 36360 1498 90590581
Shock 13.20 12.24 33 36335 28745 90563334
Prerenal failure 13.10 12.24 9 36359 2106 90589973
Glycosylated haemoglobin decreased 13.08 12.24 6 36362 643 90591436
Stress cardiomyopathy 13.04 12.24 21 36347 13334 90578745
Urticaria 12.98 12.24 73 36295 312661 90279418
Product dispensing error 12.96 12.24 20 36348 12253 90579826
Generalised tonic-clonic seizure 12.96 12.24 37 36331 34866 90557213
Blood ketone body increased 12.85 12.24 5 36363 356 90591723
Steroid withdrawal syndrome 12.85 12.24 6 36362 670 90591409
Adverse event 12.80 12.24 17 36351 117401 90474678
Foot deformity 12.79 12.24 4 36364 59647 90532432
Incorrect dose administered 12.71 12.24 64 36304 78866 90513213
Blister 12.60 12.24 56 36312 254942 90337137
Knee arthroplasty 12.59 12.24 9 36359 83173 90508906
CD4 lymphocytes abnormal 12.56 12.24 3 36365 39 90592040
Exostosis 12.44 12.24 3 36365 53131 90538948
Chronic gastritis 12.41 12.24 11 36357 3730 90588349
Histoplasmosis disseminated 12.40 12.24 9 36359 2296 90589783
Withdrawal hypertension 12.38 12.24 4 36364 165 90591914

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 1555.70 11.52 840 36271 59014 42525210
Lactic acidosis 345.19 11.52 298 36813 44963 42539261
Hypoglycaemic coma 321.47 11.52 112 36999 2632 42581592
Diabetes mellitus inadequate control 290.99 11.52 176 36935 15214 42569010
Blood glucose increased 254.40 11.52 317 36794 73382 42510842
Glycosylated haemoglobin increased 201.99 11.52 131 36980 12793 42571431
Cerebral infarction 107.27 11.52 134 36977 31035 42553189
Off label use 104.15 11.52 254 36857 638081 41946143
Diabetic ketoacidosis 100.03 11.52 110 37001 22257 42561967
Pancreatitis acute 93.39 11.52 130 36981 33434 42550790
Acute kidney injury 93.33 11.52 592 36519 366745 42217479
Hyperkalaemia 84.34 11.52 204 36907 80254 42503970
Blood glucose decreased 81.71 11.52 80 37031 14139 42570085
Pancreatitis 77.68 11.52 137 36974 43131 42541093
Hyperglycaemia 75.70 11.52 140 36971 45719 42538505
Pemphigoid 68.68 11.52 66 37045 11401 42572823
Bladder cancer 63.02 11.52 76 37035 16971 42567253
Metabolic acidosis 61.44 11.52 138 36973 51720 42532504
Blood lactic acid 55.93 11.52 18 37093 328 42583896
Hypoglycaemic encephalopathy 53.07 11.52 17 37094 305 42583919
Diabetic neuropathy 52.25 11.52 38 37073 4464 42579760
Pancreatic carcinoma 51.87 11.52 52 37059 9454 42574770
Product use in unapproved indication 51.27 11.52 51 37060 184405 42399819
Drug abuse 51.07 11.52 14 37097 104757 42479467
Necrotising oesophagitis 47.31 11.52 21 37090 950 42583274
BRASH syndrome 45.49 11.52 25 37086 1800 42582424
Diabetic metabolic decompensation 44.83 11.52 26 37085 2076 42582148
Febrile neutropenia 40.40 11.52 62 37049 185641 42398583
Euglycaemic diabetic ketoacidosis 36.61 11.52 34 37077 5626 42578598
Drug ineffective 34.15 11.52 368 36743 629829 41954395
Interstitial lung disease 34.04 11.52 147 36964 78315 42505909
Blood glucose abnormal 33.82 11.52 36 37075 7017 42577207
Blindness transient 33.41 11.52 24 37087 2765 42581459
Decreased appetite 32.64 11.52 283 36828 192854 42391370
Altered state of consciousness 32.58 11.52 76 37035 29183 42555041
Cardiac failure congestive 31.65 11.52 153 36958 85449 42498775
Renal impairment 30.54 11.52 182 36929 110046 42474178
Foetal exposure during pregnancy 30.36 11.52 3 37108 47308 42536916
Glycosylated haemoglobin decreased 29.53 11.52 12 37099 435 42583789
Hepatocellular carcinoma 29.41 11.52 36 37075 8158 42576066
Diabetes mellitus 28.74 11.52 116 36995 59971 42524253
Type 2 diabetes mellitus 28.73 11.52 55 37056 18416 42565808
Lipase increased 28 11.52 40 37071 10526 42573698
Diabetic nephropathy 27.72 11.52 20 37091 2321 42581903
Myocardial infarction 27.16 11.52 193 36918 123816 42460408
Dehydration 26.75 11.52 213 36898 141554 42442670
Hypoglycaemic unconsciousness 25.99 11.52 13 37098 771 42583453
Hypothermia 25.58 11.52 42 37069 12473 42571751
Pancreatic carcinoma metastatic 24.40 11.52 21 37090 3145 42581079
Urine ketone body present 23.93 11.52 15 37096 1379 42582845
Pyrexia 23.78 11.52 224 36887 393818 42190406
Diabetic retinopathy 23.01 11.52 17 37094 2046 42582178
Coronary artery stenosis 22.81 11.52 36 37075 10343 42573881
Gastric cancer 22.66 11.52 29 37082 6874 42577350
Dyslalia 22.45 11.52 11 37100 624 42583600
Coronary artery disease 22.04 11.52 99 37012 53621 42530603
Treatment failure 21.52 11.52 14 37097 62610 42521614
Albumin urine present 20.53 11.52 9 37102 395 42583829
Product commingling 20.39 11.52 5 37106 31 42584193
Drug resistance 19.94 11.52 3 37108 34245 42549979
Renal failure 19.46 11.52 201 36910 143525 42440699
Cholangiocarcinoma 19.34 11.52 14 37097 1632 42582592
Thrombotic cerebral infarction 19.25 11.52 9 37102 460 42583764
Ketonuria 19.08 11.52 10 37101 654 42583570
Mucosal inflammation 18.42 11.52 10 37101 49364 42534860
Cardiac failure 18.24 11.52 157 36954 106699 42477525
Aggression 17.91 11.52 8 37103 44155 42540069
Joint swelling 17.54 11.52 20 37091 68002 42516222
Acute myocardial infarction 17.37 11.52 98 37013 58067 42526157
Hyperglycaemic hyperosmolar nonketotic syndrome 17.30 11.52 13 37098 1605 42582619
Hypotony of eye 17.27 11.52 7 37104 252 42583972
Brain stem infarction 17.22 11.52 12 37099 1318 42582906
Bladder transitional cell carcinoma 17.16 11.52 16 37095 2660 42581564
Amylase increased 17.14 11.52 25 37086 6704 42577520
Diabetic ketosis 17.07 11.52 7 37104 260 42583964
Shock 17.05 11.52 60 37051 29061 42555163
Latent autoimmune diabetes in adults 16.94 11.52 6 37105 148 42584076
Pancreatitis necrotising 16.40 11.52 18 37093 3631 42580593
Anxiety 16.31 11.52 51 37060 118509 42465715
Blood glucose fluctuation 16.22 11.52 20 37091 4567 42579657
Hepatic cirrhosis 15.56 11.52 45 37066 19657 42564567
Colon cancer 15.27 11.52 29 37082 9652 42574572
Cytokine release syndrome 15.23 11.52 10 37101 44517 42539707
Blood ketone body increased 15.17 11.52 8 37103 530 42583694
Stress 15.03 11.52 10 37101 44202 42540022
Cerebral congestion 15.01 11.52 5 37106 102 42584122
Heat illness 14.84 11.52 7 37104 365 42583859
Prerenal failure 14.56 11.52 14 37097 2419 42581805
Lower respiratory tract infection 14.44 11.52 9 37102 41197 42543027
Neutropenia 14.42 11.52 108 37003 199323 42384901
Cerebral haemorrhage 13.93 11.52 69 37042 38897 42545327
Diabetic gangrene 13.87 11.52 6 37105 255 42583969
Nephrogenic anaemia 13.84 11.52 14 37097 2572 42581652
Blood lactic acid increased 13.83 11.52 25 37086 8014 42576210
Mouth swelling 13.58 11.52 13 37098 2233 42581991
Carotid artery stenosis 13.56 11.52 20 37091 5416 42578808
Loss of personal independence in daily activities 13.56 11.52 14 37097 49802 42534422
Condition aggravated 13.33 11.52 154 36957 260600 42323624
Product quality issue 13.32 11.52 40 37071 17842 42566382
Migraine 13.14 11.52 3 37108 25411 42558813
Product contamination chemical 13.13 11.52 3 37108 13 42584211
Chronic kidney disease 13.06 11.52 78 37033 47163 42537061
Blastocystis infection 12.95 11.52 3 37108 14 42584210
Dizziness 12.66 11.52 295 36816 248959 42335265
Myelosuppression 12.65 11.52 10 37101 40451 42543773
Myocardial ischaemia 12.55 11.52 39 37072 17723 42566501
Toe amputation 12.39 11.52 14 37097 2915 42581309
Ischaemic stroke 12.33 11.52 45 37066 22188 42562036
Psychotic disorder 12.31 11.52 5 37106 29203 42555021
Respiratory tract haemorrhage 12.21 11.52 10 37101 1399 42582825
Intentional product misuse 12.20 11.52 22 37089 61878 42522346
Chorea 11.99 11.52 10 37101 1434 42582790
Depression 11.98 11.52 53 37058 111310 42472914
Toxicity to various agents 11.84 11.52 135 36976 229001 42355223
Cerebrovascular accident 11.80 11.52 133 36978 97027 42487197
Adenocarcinoma pancreas 11.70 11.52 10 37101 1484 42582740
Bladder neoplasm 11.62 11.52 10 37101 1497 42582727
Hyperthyroidism 11.56 11.52 33 37078 14308 42569916

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 3552.47 10.92 1594 61847 114510 110411348
Lactic acidosis 967.67 10.92 624 62817 92187 110433671
Hypoglycaemic coma 690.67 10.92 214 63227 5319 110520539
Diabetes mellitus inadequate control 501.22 10.92 273 63168 29502 110496356
Blood glucose increased 476.37 10.92 477 62964 132019 110393839
Glycosylated haemoglobin increased 384.91 10.92 212 63229 23407 110502451
Acute kidney injury 376.90 10.92 1000 62441 634430 109891428
Diabetic ketoacidosis 249.49 10.92 201 63240 41857 110484001
Hypoglycaemic encephalopathy 239.74 10.92 60 63381 653 110525205
Cerebral infarction 211.15 10.92 200 63241 51638 110474220
Hyperglycaemia 210.78 10.92 252 63189 84838 110441020
Hyperkalaemia 207.66 10.92 318 63123 135478 110390380
Blood glucose decreased 168.69 10.92 138 63303 29350 110496508
Metabolic acidosis 165.91 10.92 243 63198 99501 110426357
Euglycaemic diabetic ketoacidosis 164.11 10.92 95 63346 11528 110514330
Pancreatitis acute 151.70 10.92 180 63261 60094 110465764
Diabetic metabolic decompensation 139.77 10.92 60 63381 3829 110522029
Off label use 138.69 10.92 423 63018 1499762 109026096
Synovitis 131.82 10.92 6 63435 274086 110251772
Systemic lupus erythematosus 124.19 10.92 5 63436 254333 110271525
Joint swelling 123.10 10.92 50 63391 442795 110083063
Dehydration 120.09 10.92 393 63048 279118 110246740
Infusion related reaction 116.19 10.92 37 63404 381125 110144733
Renal failure 111.53 10.92 334 63107 226240 110299618
Lower respiratory tract infection 105.93 10.92 9 63432 243097 110282761
Pancreatitis 104.04 10.92 190 63251 93343 110432515
Drug intolerance 103.43 10.92 52 63389 406460 110119398
Maternal exposure during pregnancy 101.90 10.92 13 63428 254870 110270988
Bladder cancer 99.68 10.92 87 63354 20205 110505653
Pemphigus 96.13 10.92 7 63434 214563 110311295
Glossodynia 92.02 10.92 10 63431 221994 110303864
Pemphigoid 87.88 10.92 80 63361 19627 110506231
Helicobacter infection 87.37 10.92 4 63437 181873 110343985
Renal impairment 86.37 10.92 271 63170 188174 110337684
Duodenal ulcer perforation 85.06 10.92 4 63437 177696 110348162
Drug ineffective 84.81 10.92 519 62922 1520021 109005837
Product use in unapproved indication 80.19 10.92 83 63358 447294 110078564
Altered state of consciousness 79.77 10.92 129 63312 57497 110468361
Pancreatic carcinoma 79.64 10.92 67 63374 14805 110511053
Hypersensitivity 78.16 10.92 70 63371 403928 110121930
Drug interaction 76.54 10.92 520 62921 499663 110026195
Diabetic neuropathy 75.13 10.92 48 63393 6951 110518907
Diabetes mellitus 73.94 10.92 171 63270 99210 110426648
Exposure during pregnancy 73.47 10.92 6 63435 167418 110358440
Therapeutic product effect decreased 72.16 10.92 25 63416 244291 110281567
Pericarditis 69.02 10.92 20 63421 219094 110306764
Irritable bowel syndrome 66.54 10.92 8 63433 164207 110361651
Alopecia 66.11 10.92 67 63374 364686 110161172
Wound 64.23 10.92 27 63414 234410 110291448
Ketoacidosis 63.63 10.92 50 63391 10037 110515821
Hypothermia 63.62 10.92 77 63364 26225 110499633
Blood glucose abnormal 62.68 10.92 55 63386 12861 110512997
Ill-defined disorder 62.67 10.92 8 63433 156845 110369013
Loss of consciousness 62.14 10.92 250 63191 196056 110329802
Fibromyalgia 60.90 10.92 12 63429 170897 110354961
Decreased appetite 60.31 10.92 473 62968 475373 110050485
Blood lactic acid 57.59 10.92 18 63423 460 110525398
BRASH syndrome 56.76 10.92 32 63409 3691 110522167
Fall 55.88 10.92 560 62881 602922 109922936
Arthropathy 55.37 10.92 50 63391 287472 110238386
Psoriatic arthropathy 54.97 10.92 22 63419 196739 110329119
Wheezing 54.60 10.92 40 63401 255190 110270668
Hepatocellular carcinoma 53.91 10.92 45 63396 9835 110516023
Bursitis 53.45 10.92 6 63435 129912 110395946
Diarrhoea 53.25 10.92 933 62508 1138572 109387286
Contraindicated product administered 52.99 10.92 39 63402 248228 110277630
Treatment failure 52.45 10.92 49 63392 277185 110248673
Swelling 52.43 10.92 75 63366 350966 110174892
Myocardial infarction 51.79 10.92 233 63208 191850 110334008
Hyperglycaemic hyperosmolar nonketotic syndrome 51.75 10.92 28 63413 2981 110522877
Mobility decreased 51.06 10.92 37 63404 237385 110288473
C-reactive protein abnormal 50.89 10.92 7 63434 129688 110396170
MELAS syndrome 50.82 10.92 15 63426 314 110525544
Migraine 49.93 10.92 18 63423 171634 110354224
Rheumatoid arthritis 49.89 10.92 59 63382 299554 110226304
Eosinophilic myocarditis 49.18 10.92 24 63417 2061 110523797
Necrotising oesophagitis 48.81 10.92 22 63419 1578 110524280
Sinusitis 48.79 10.92 59 63382 296629 110229229
Injury 47.62 10.92 21 63420 177244 110348614
Pain 46.95 10.92 338 63103 954617 109571241
Interstitial lung disease 46.95 10.92 181 63260 139153 110386705
Joint range of motion decreased 46.82 10.92 7 63434 121825 110404033
Intentional product use issue 46.67 10.92 44 63397 247862 110277996
Drug abuse 46.13 10.92 22 63419 177389 110348469
Impaired healing 45.88 10.92 28 63413 196689 110329169
Lip dry 45.58 10.92 3 63438 100080 110425778
Urine ketone body present 45.36 10.92 28 63413 3818 110522040
Cardiac failure congestive 45.16 10.92 189 63252 150811 110375047
Cardiac failure 43.59 10.92 218 63223 187408 110338450
Glycosylated haemoglobin decreased 43.44 10.92 17 63424 855 110525003
Arthralgia 43.29 10.92 266 63175 779366 109746492
Sopor 42.87 10.92 76 63365 36470 110489388
Musculoskeletal stiffness 42.55 10.92 59 63382 279763 110246095
Rhabdomyolysis 41.87 10.92 158 63283 120243 110405615
Hepatic enzyme increased 41.84 10.92 75 63366 320817 110205041
Inflammation 41.70 10.92 30 63411 193208 110332650
Drug level increased 41 10.92 87 63354 47632 110478226
Drug hypersensitivity 40.27 10.92 130 63311 453960 110071898
Cold sweat 40.02 10.92 56 63385 21975 110503883
Hyperthyroidism 39.80 10.92 65 63376 29196 110496662
Diabetic retinopathy 39.64 10.92 25 63416 3539 110522319
Colon cancer 37.92 10.92 47 63394 16396 110509462
Acute myocardial infarction 37.91 10.92 120 63321 83657 110442201
Nasopharyngitis 37.75 10.92 109 63332 394252 110131606
Diabetic nephropathy 37.51 10.92 24 63417 3484 110522374
Night sweats 37.38 10.92 15 63426 133968 110391890
Bladder transitional cell carcinoma 37.07 10.92 22 63419 2794 110523064
Sleep disorder 36.52 10.92 36 63405 198608 110327250
Shock 36.38 10.92 89 63352 53499 110472359
Infection 36.23 10.92 98 63343 362102 110163756
Neuroglycopenia 36.00 10.92 16 63425 1110 110524748
Ketosis 34.92 10.92 18 63423 1736 110524122
Grip strength decreased 34.82 10.92 3 63438 80171 110445687
Hypoglycaemic unconsciousness 34.77 10.92 16 63425 1204 110524654
Cardiac arrest 34.58 10.92 212 63229 196541 110329317
Blood glucose fluctuation 33.83 10.92 31 63410 7667 110518191
Bradycardia 33.54 10.92 177 63264 155340 110370518
Osteoarthritis 32.54 10.92 34 63407 182589 110343269
Postprandial hypoglycaemia 31.82 10.92 9 63432 161 110525697
Lipase increased 31.76 10.92 46 63395 18626 110507232
Febrile neutropenia 31.45 10.92 86 63355 316681 110209177
Hyperinsulinaemia 31.23 10.92 10 63431 277 110525581
Headache 31.10 10.92 340 63101 882037 109643821
Insulin C-peptide increased 30.56 10.92 9 63432 187 110525671
Blood cholesterol increased 30.10 10.92 37 63404 184748 110341110
Prerenal failure 30.08 10.92 23 63418 4436 110521422
Discomfort 29.98 10.92 48 63393 214659 110311199
Product use issue 29.93 10.92 86 63355 311609 110214249
Peripheral venous disease 29.76 10.92 6 63435 84111 110441747
Dyslalia 29.75 10.92 15 63426 1382 110524476
Therapy non-responder 29.50 10.92 28 63413 157279 110368579
Anaemia 29.50 10.92 459 62982 546627 109979231
Gastrointestinal disorder 29.38 10.92 59 63382 241893 110283965
Pancreatic carcinoma metastatic 29.24 10.92 22 63419 4142 110521716
Gastroenteritis 29.11 10.92 67 63374 38733 110487125
Cholelithiasis 28.83 10.92 91 63350 63331 110462527
Stomatitis 28.64 10.92 71 63370 270171 110255687
Albumin urine present 28.33 10.92 12 63429 741 110525117
Urinary tract infection 28.33 10.92 299 63142 325983 110199875
Contusion 28.25 10.92 57 63384 233304 110292554
Blindness transient 28.18 10.92 25 63416 5931 110519927
Liver injury 27.95 10.92 27 63414 150386 110375472
Gastric cancer 27.89 10.92 33 63408 10975 110514883
Pancreatitis necrotising 27.85 10.92 24 63417 5477 110520381
Atrial fibrillation 27.79 10.92 226 63215 229416 110296442
Anuria 27.75 10.92 50 63391 24291 110501567
Thrombotic cerebral infarction 27.71 10.92 12 63429 782 110525076
Cerebral haemorrhage 27.53 10.92 91 63350 64877 110460981
Ischaemic stroke 27.44 10.92 68 63373 41195 110484663
Blood creatinine increased 27.21 10.92 189 63252 182700 110343158
Azotaemia 26.83 10.92 31 63410 10054 110515804
Coronary artery stenosis 26.53 10.92 36 63405 13722 110512136
Blood ketone body increased 26.42 10.92 12 63429 876 110524982
Oliguria 26.13 10.92 42 63399 18615 110507243
Condition aggravated 25.93 10.92 283 63158 734553 109791305
Syncope 25.41 10.92 201 63240 202335 110323523
Wound infection 25.01 10.92 12 63429 96453 110429405
Cerebral congestion 24.90 10.92 8 63433 224 110525634
Coronary artery disease 24.85 10.92 94 63347 71596 110454262
Chorea 24.76 10.92 18 63423 3217 110522641
Autoimmune disorder 24.62 10.92 4 63437 65479 110460379
Cholangiocarcinoma 24.26 10.92 17 63424 2868 110522990
Blood insulin increased 24.12 10.92 9 63432 397 110525461
Blood lactic acid increased 24.08 10.92 37 63404 15784 110510074
Chronic kidney disease 23.99 10.92 97 63344 76194 110449664
Vascular access site haemorrhage 23.98 10.92 8 63433 253 110525605
Embolic cerebellar infarction 23.72 10.92 5 63436 23 110525835
Abdominal discomfort 23.61 10.92 131 63310 393727 110132131
Dysarthria 23.37 10.92 103 63338 84018 110441840
Nail disorder 23.03 10.92 3 63438 57932 110467926
Angina pectoris 22.70 10.92 83 63358 62212 110463646
Myelosuppression 22.59 10.92 13 63428 94327 110431531
Latent autoimmune diabetes in adults 22.43 10.92 7 63434 178 110525680
Hepatic function abnormal 22.33 10.92 106 63335 89189 110436669
Cholecystitis 22.01 10.92 47 63394 25835 110500023
Hyperhidrosis 21.94 10.92 183 63258 187115 110338743
Musculoskeletal pain 21.90 10.92 45 63396 182978 110342880
Anxiety 21.66 10.92 113 63328 344965 110180893
Ectopic ACTH syndrome 21.40 10.92 7 63434 208 110525650
Asthma 21.24 10.92 73 63368 250218 110275640
Cerebrovascular accident 21.17 10.92 177 63264 181107 110344751
Ketonuria 20.98 10.92 12 63429 1423 110524435
Polyuria 20.95 10.92 37 63404 17701 110508157
Dermatitis exfoliative 20.84 10.92 29 63412 11318 110514540
Urticaria 20.81 10.92 103 63338 318754 110207104
Unresponsive to stimuli 20.77 10.92 82 63359 63708 110462150
Pyelonephritis acute 20.59 10.92 23 63418 7190 110518668
Potentiating drug interaction 20.26 10.92 29 63412 11614 110514244
Hypoparathyroidism 20.26 10.92 12 63429 1518 110524340
Drug resistance 19.99 10.92 4 63437 56370 110469488
Biopsy skin abnormal 19.78 10.92 7 63434 265 110525593
Joint stiffness 19.64 10.92 7 63434 67236 110458622
Bile duct stone 19.60 10.92 21 63420 6268 110519590
Glomerular filtration rate decreased 19.55 10.92 48 63393 28908 110496950
Depression 19.31 10.92 105 63336 317230 110208628
Injection site nodule 19.05 10.92 18 63423 4628 110521230
Peripheral arterial occlusive disease 19.00 10.92 25 63416 9255 110516603
Ballismus 18.78 10.92 7 63434 308 110525550
Blood triglycerides increased 18.71 10.92 42 63399 23884 110501974
Loss of personal independence in daily activities 18.71 10.92 36 63405 149984 110375874
Intentional overdose 18.58 10.92 135 63306 132366 110393492
Dry mouth 18.58 10.92 56 63385 199892 110325966
Chronic gastritis 18.53 10.92 19 63422 5392 110520466
Diabetic complication 18.43 10.92 11 63430 1411 110524447
Frequent bowel movements 18.33 10.92 9 63432 71381 110454477
Weight decreased 18.20 10.92 373 63068 467684 110058174
Toe amputation 18.16 10.92 17 63424 4321 110521537
Foot deformity 18.14 10.92 3 63438 48477 110477381
Urine ketone body 17.92 10.92 6 63435 192 110525666
Embolic cerebral infarction 17.85 10.92 11 63430 1495 110524363
Hip arthroplasty 17.74 10.92 5 63436 55808 110470050
Hyporesponsive to stimuli 17.66 10.92 14 63427 2846 110523012
Platelet count decreased 17.62 10.92 206 63235 230237 110295621
Product prescribing error 17.54 10.92 67 63374 51264 110474594
Poverty of speech 17.50 10.92 8 63433 593 110525265
Ureteric cancer recurrent 17.31 10.92 4 63437 30 110525828
Amylase increased 17.28 10.92 28 63413 12491 110513367
Anaemia vitamin B12 deficiency 17.24 10.92 10 63431 1217 110524641
Lower limb fracture 17.18 10.92 11 63430 75337 110450521
Compartment syndrome 17.14 10.92 19 63422 5891 110519967
Paraesthesia 17.10 10.92 91 63350 276430 110249428
Osteoporosis 16.95 10.92 15 63426 87137 110438721
Gastrointestinal haemorrhage 16.93 10.92 157 63284 165361 110360497
Diabetic ketosis 16.91 10.92 9 63432 927 110524931
Hyponatraemia 16.83 10.92 195 63246 217458 110308400
Diabetic gangrene 16.76 10.92 6 63435 235 110525623
Onychomadesis 16.70 10.92 3 63438 45660 110480198
Colitis ulcerative 16.69 10.92 12 63429 77351 110448507
Brain stem infarction 16.62 10.92 12 63429 2122 110523736
Product commingling 16.30 10.92 5 63436 120 110525738
Obesity 16.14 10.92 25 63416 113326 110412532
Hypotony of eye 16.00 10.92 7 63434 468 110525390
Sleep disorder due to a general medical condition 15.96 10.92 5 63436 52107 110473751
Glycosylated haemoglobin abnormal 15.87 10.92 7 63434 477 110525381
Electrolyte imbalance 15.80 10.92 52 63389 36976 110488882
Peripheral swelling 15.70 10.92 152 63289 403882 110121976
Hemiplegia 15.63 10.92 38 63403 22744 110503114
Glomerulonephritis minimal lesion 15.62 10.92 9 63432 1082 110524776
Sciatica 15.58 10.92 18 63423 92381 110433477
Retinal haemorrhage 15.57 10.92 23 63418 9478 110516380
Embolic stroke 15.55 10.92 22 63419 8721 110517137
Nephrogenic anaemia 15.54 10.92 16 63425 4561 110521297
CSF protein increased 15.45 10.92 10 63431 1481 110524377
Atrioventricular block complete 15.42 10.92 35 63406 20047 110505811
Erythema multiforme 15.35 10.92 36 63405 21061 110504797
Continuous haemodiafiltration 15.34 10.92 11 63430 1924 110523934
Renal arteriosclerosis 15.34 10.92 7 63434 517 110525341
Hepatic steatosis 15.28 10.92 62 63379 48769 110477089
Testicular pain 15.23 10.92 12 63429 2417 110523441
Facial paralysis 15.16 10.92 39 63402 24175 110501683
Retinopathy proliferative 15.11 10.92 5 63436 154 110525704
Gait inability 15.10 10.92 35 63406 136341 110389517
Hypercholesterolaemia 14.99 10.92 18 63423 90819 110435039
Low density lipoprotein increased 14.92 10.92 24 63417 10642 110515216
Exostosis 14.82 10.92 4 63437 45952 110479906
Myocardial ischaemia 14.71 10.92 41 63400 26643 110499215
Carotid artery stenosis 14.57 10.92 22 63419 9241 110516617
Hypoaesthesia 14.52 10.92 113 63328 314110 110211748
Ventricular tachycardia 14.48 10.92 62 63379 49947 110475911
Blood potassium increased 14.47 10.92 47 63394 33202 110492656
Testicular swelling 14.38 10.92 10 63431 1666 110524192
Drug ineffective for unapproved indication 14.34 10.92 23 63418 102815 110423043
Blood creatine phosphokinase increased 14.28 10.92 81 63360 72996 110452862
Metabolic encephalopathy 14.28 10.92 24 63417 11036 110514822
Cardiac failure acute 14.27 10.92 38 63403 24040 110501818
Disorientation 14.26 10.92 79 63362 70592 110455266
Mixed anxiety and depressive disorder 13.89 10.92 7 63434 644 110525214
Hypoglycaemic seizure 13.87 10.92 8 63433 964 110524894
Mouth swelling 13.81 10.92 19 63422 7335 110518523
Pancreatic disorder 13.81 10.92 14 63427 3920 110521938
Glucose urine present 13.69 10.92 11 63430 2278 110523580
Reperfusion injury 13.61 10.92 5 63436 211 110525647
Idiopathic CD4 lymphocytopenia 13.57 10.92 3 63438 18 110525840
Coeliac disease 13.48 10.92 4 63437 43183 110482675
Gastric adenoma 13.43 10.92 3 63438 19 110525839
Inability to afford medication 13.39 10.92 14 63427 4062 110521796
Phobia 13.38 10.92 6 63435 425 110525433
Dizziness 13.37 10.92 508 62933 697685 109828173
Asthenia 13.36 10.92 502 62939 688497 109837361
Rash 13.28 10.92 364 63077 820600 109705258
Troponin I increased 13.25 10.92 16 63425 5436 110520422
Ear pain 13.23 10.92 7 63434 53219 110472639
Cholangitis acute 13.19 10.92 10 63431 1903 110523955
Pulmonary fibrosis 13.15 10.92 24 63417 102018 110423840
Lung disorder 13.02 10.92 56 63385 179991 110345867
Shock hypoglycaemic 13.00 10.92 5 63436 240 110525618
Lacunar infarction 12.97 10.92 17 63424 6269 110519589
Kussmaul respiration 12.96 10.92 6 63435 458 110525400
Mucosal inflammation 12.94 10.92 22 63419 96119 110429739
Knee arthroplasty 12.84 10.92 11 63430 64937 110460921
Adverse event 12.80 10.92 27 63414 108782 110417076
Hypotension 12.76 10.92 392 63049 523457 110002401
Gingival hypertrophy 12.69 10.92 14 63427 4317 110521541
Cytokine release syndrome 12.62 10.92 13 63428 70293 110455565
Heat illness 12.60 10.92 7 63434 785 110525073
Anxiety disorder 12.59 10.92 15 63426 5025 110520833
Coagulation test abnormal 12.54 10.92 9 63432 1577 110524281
Hypomagnesaemia 12.52 10.92 68 63373 60302 110465556
Skin squamous cell carcinoma recurrent 12.52 10.92 4 63437 110 110525748
Accidental exposure to product by child 12.37 10.92 12 63429 3186 110522672
Blister 12.35 10.92 78 63363 227298 110298560
Pancreatitis chronic 12.34 10.92 14 63427 4451 110521407
Pylorus dilatation 12.22 10.92 3 63438 30 110525828
Arthritis 12.20 10.92 52 63389 167534 110358324
Blood pressure fluctuation 12.16 10.92 15 63426 74809 110451049
Feeling hot 12.12 10.92 21 63420 91085 110434773
Skin turgor decreased 12.06 10.92 7 63434 853 110525005
Microalbuminuria 12.02 10.92 8 63433 1241 110524617
Vitamin B12 deficiency 11.91 10.92 21 63420 10034 110515824
Acidosis 11.81 10.92 34 63407 22497 110503361
Pulmonary hilar enlargement 11.80 10.92 4 63437 133 110525725
Ophthalmic herpes zoster 11.77 10.92 12 63429 3383 110522475
Quadriparesis 11.74 10.92 14 63427 4693 110521165
Adenocarcinoma pancreas 11.72 10.92 10 63431 2253 110523605
Cerebral reperfusion injury 11.64 10.92 3 63438 37 110525821
Differential white blood cell count abnormal 11.64 10.92 10 63431 2274 110523584
Diverticulum intestinal haemorrhagic 11.61 10.92 14 63427 4749 110521109
Urinary retention 11.56 10.92 74 63367 69609 110456249
Blood creatine phosphokinase MB increased 11.43 10.92 11 63430 2892 110522966
Injection site reaction 11.43 10.92 21 63420 89049 110436809
Immunodeficiency 11.41 10.92 4 63437 38834 110487024
Urogenital haemorrhage 11.32 10.92 7 63434 957 110524901
Oedema peripheral 11.19 10.92 257 63184 328403 110197455
Hypertriglyceridaemia 11.14 10.92 27 63414 16127 110509731
Pulmonary oedema 11.07 10.92 97 63344 100562 110425296
Hyperventilation 11.00 10.92 19 63422 8928 110516930
Tremor 10.99 10.92 170 63271 202062 110323796
Carotid arteriosclerosis 10.95 10.92 11 63430 3046 110522812

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BB12 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
ATC A10BD04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Combinations of oral blood glucose lowering drugs
ATC A10BD06 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Combinations of oral blood glucose lowering drugs
ATC A10BD32 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Combinations of oral blood glucose lowering drugs
FDA CS M0020795 Sulfonylurea Compounds
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D007004 Hypoglycemic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:90415 insulin secretagogue
CHEBI has role CHEBI:145947 antiatherosclerotic agent
FDA EPC N0000175608 Sulfonylurea

Related Drugs by ATC class:

A10BB Sulfonylureas 12 drugs
acetohexamidecarbutamidechlorpropamideglibenclamideglibornuridegliclazideglipizidegliquidoneglisoxepidemetahexamidetolazamidetolbutamide
A10BD Combinations of oral blood glucose lowering drugs 19 drugs
acarbosealogliptincanagliflozindapagliflozinempagliflozinertugliflozinevogliptingemigliptinlinagliptinlobeglitazonemetforminphenformin show all 19 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352
Treatment Refractory Type 2 Diabetes Mellitus indication
Alcoholism contraindication 7200002
Weight gain finding contraindication 8943002
Asthenia contraindication 13791008
Pulmonary edema contraindication 19242006 DOID:11396
Myocardial infarction contraindication 22298006 DOID:5844
Macular retinal edema contraindication 37231002 DOID:4449
Infectious disease contraindication 40733004
Body fluid retention contraindication 43498006
Chronic heart failure contraindication 48447003
Hepatic porphyria contraindication 55056006 DOID:3133
Hemolytic anemia contraindication 61261009 DOID:583
Glucose-6-phosphate dehydrogenase deficiency anemia contraindication 62403005
Osteoporosis contraindication 64859006 DOID:11476
Hypopituitarism contraindication 74728003 DOID:9406
Kidney disease contraindication 90708001 DOID:557
Fracture of bone contraindication 125605004
Autonomic dysreflexia contraindication 129618003
Liver function tests abnormal contraindication 166603001
Angina pectoris contraindication 194828000
Decompensated cardiac failure contraindication 195111005
Cerebrovascular accident contraindication 230690007
Disease of liver contraindication 235856003 DOID:409
Drug-induced hepatitis contraindication 235876009
Hypoglycemic disorder contraindication 237630007
Edema contraindication 267038008
Osteopenia contraindication 312894000
Primary adrenocortical insufficiency contraindication 373662000
Fever contraindication 386661006
Surgical procedure contraindication 387713003
Malignant tumor of urinary bladder contraindication 399326009 DOID:11054
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic injury contraindication 417746004
Fever greater than 100.4 Fahrenheit contraindication 426000000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.31 acidic
pKa2 13.98 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Ki 9.24 WOMBAT-PK CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 6.07 CHEMBL
Sulfonylurea receptor 2, Kir6.2 Ion channel BLOCKER Ki 7.98 WOMBAT-PK

External reference:

IDSource
4020945 VUID
N0000148425 NUI
D00593 KEGG_DRUG
4020945 VANDF
C0061323 UMLSCUI
CHEBI:5383 CHEBI
GMR PDB_CHEM_ID
CHEMBL1481 ChEMBL_ID
DB00222 DRUGBANK_ID
C057619 MESH_SUPPLEMENTAL_RECORD_UI
6820 IUPHAR_LIGAND_ID
5718 INN_ID
6KY687524K UNII
3476 PUBCHEM_CID
25789 RXNORM
4782 MMSL
72042 MMSL
d03864 MMSL
005624 NDDF
109079009 SNOMEDCT_US
386966003 SNOMEDCT_US
6KY687524K INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0440-6564 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0440-6565 TABLET 2 mg ORAL ANDA 26 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0440-6566 TABLET 4 mg ORAL ANDA 26 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8332 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8333 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8334 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 10544-217 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 10544-219 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-773 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-774 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-775 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-001 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-001 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-002 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-002 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-003 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-003 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 21695-746 TABLET 2 mg ORAL ANDA 20 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 21695-747 TABLET 4 mg ORAL ANDA 20 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 21695-993 TABLET 1 mg ORAL ANDA 20 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 33261-831 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 33261-892 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 33261-961 TABLET 1 mg ORAL ANDA 26 sections
GLIMEPIRIDE HUMAN PRESCRIPTION DRUG LABEL 1 42549-498 TABLET 4 mg ORAL ANDA 28 sections
GLIMEPIRIDE HUMAN PRESCRIPTION DRUG LABEL 1 42549-499 TABLET 2 mg ORAL ANDA 24 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 42571-100 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 42571-101 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 42571-102 TABLET 3 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 42571-103 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 42571-104 TABLET 6 mg ORAL ANDA 25 sections