gliclazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 1299 21187-98-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gliclazide
  • diabezidum
  • diabrezide
  • diabyl
  • diaprel
  • glimicron
  • glinormax
  • glyzide
  • gliclazid
  • dizalid
  • S 1702
An oral sulfonylurea hypoglycemic agent which stimulates insulin secretion.
  • Molecular weight: 323.41
  • Formula: C15H21N3O3S
  • CLOGP: 1.09
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 78.51
  • ALOGS: -3.23
  • ROTB: 2

Drug dosage:

DoseUnitRoute
60 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.13 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 97 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.43 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.41 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.03 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 16.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1972 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 683.28 13.18 421 34712 59644 63394245
Lactic acidosis 609.68 13.18 334 34799 37953 63415936
Acute kidney injury 386.31 13.18 592 34541 262823 63191066
Diabetes mellitus inadequate control 314.88 13.18 158 34975 14968 63438921
Diabetic ketoacidosis 296.46 13.18 168 34965 20337 63433552
Hyperglycaemia 218.74 13.18 183 34950 41684 63412205
Hyperkalaemia 191.10 13.18 190 34943 54013 63399876
Hypoglycaemic coma 136.51 13.18 52 35081 2523 63451366
Malignant mediastinal neoplasm 133.14 13.18 44 35089 1402 63452487
Ketoacidosis 128.65 13.18 58 35075 4320 63449569
Diabetic metabolic decompensation 122.08 13.18 43 35090 1667 63452222
Euglycaemic diabetic ketoacidosis 121.89 13.18 53 35080 3621 63450268
Metabolic acidosis 116.41 13.18 134 34999 44935 63408954
Hyponatraemia 116.13 13.18 216 34917 111684 63342205
Gangrene 107.33 13.18 57 35076 6066 63447823
Glycosylated haemoglobin increased 101.84 13.18 71 35062 12327 63441562
Arterial occlusive disease 100.32 13.18 54 35079 5904 63447985
Multiple drug therapy 96.76 13.18 45 35088 3601 63450288
Blood immunoglobulin E increased 91.39 13.18 44 35089 3805 63450084
Loss of employment 86.47 13.18 36 35097 2208 63451681
Gastric disorder 84.77 13.18 104 35029 37265 63416624
Pneumonia aspiration 81.39 13.18 98 35035 34442 63419447
Pemphigoid 79.59 13.18 50 35083 7294 63446595
Arthropathy 78.54 13.18 17 35116 234775 63219114
Hypersensitivity 73.57 13.18 35 35098 292650 63161239
Hyperlactacidaemia 72.01 13.18 34 35099 2815 63451074
Blood glucose increased 70.33 13.18 148 34985 83608 63370281
Tubulointerstitial nephritis 66.85 13.18 68 35065 19835 63434054
Pancreatitis acute 65.51 13.18 78 35055 27088 63426801
Treatment failure 65.37 13.18 15 35118 199028 63254861
Angina pectoris 62.30 13.18 80 35053 29998 63423891
Completed suicide 61.79 13.18 5 35128 145668 63308221
Discomfort 60.46 13.18 10 35123 167364 63286525
Hepatic steatosis 58.77 13.18 76 35057 28693 63425196
Drug interaction 57.42 13.18 265 34868 228866 63225023
Wound 56.27 13.18 11 35122 163252 63290637
Acne 54.72 13.18 66 35067 23227 63430662
Maternal exposure during pregnancy 54.23 13.18 27 35106 220035 63233854
Death 53.22 13.18 78 35055 374303 63079586
Infusion related reaction 52.19 13.18 36 35097 245485 63208404
Parkinsonism 51.13 13.18 44 35089 10395 63443494
Product dose omission issue 50.28 13.18 34 35099 234279 63219610
Urinary retention 49.73 13.18 72 35061 30229 63423660
Melaena 49.61 13.18 72 35061 30293 63423596
Coma 48.61 13.18 109 35024 64255 63389634
Synovitis 45.95 13.18 23 35110 186895 63266994
Skin haemorrhage 44.35 13.18 40 35093 10054 63443835
Motor dysfunction 44.08 13.18 41 35092 10720 63443169
Neurologic neglect syndrome 43.96 13.18 24 35109 2697 63451192
Dementia 43.74 13.18 53 35080 18741 63435148
Carotid artery thrombosis 43.37 13.18 24 35109 2770 63451119
Exposure during pregnancy 43.22 13.18 16 35117 155531 63298358
Drug ineffective 42.73 13.18 372 34761 1044393 62409496
Malaise 42.53 13.18 383 34750 415571 63038318
Medication error 42.26 13.18 91 35042 52193 63401696
Bronchiectasis 41.67 13.18 48 35085 16094 63437795
Butterfly rash 41.28 13.18 20 35113 1753 63452136
Stomatitis 40.74 13.18 13 35120 138712 63315177
Pain 40.22 13.18 243 34890 740385 62713504
Mesenteric panniculitis 40.21 13.18 10 35123 110 63453779
Helicobacter infection 39.86 13.18 3 35130 92782 63361107
Exercise tolerance decreased 39.44 13.18 29 35104 5468 63448421
Infection 38.51 13.18 42 35091 229131 63224758
Infected dermal cyst 38.20 13.18 13 35120 454 63453435
Transplant dysfunction 37.91 13.18 27 35106 4845 63449044
Haemoglobin increased 37.45 13.18 24 35109 3622 63450267
Blood pressure inadequately controlled 37.39 13.18 27 35106 4951 63448938
Periorbital oedema 36.37 13.18 28 35105 5656 63448233
Renal tubular disorder 36.13 13.18 21 35112 2661 63451228
Cataract 35.90 13.18 90 35043 56963 63396926
Personality disorder 35.82 13.18 28 35105 5783 63448106
Peripheral circulatory failure 35.52 13.18 15 35118 953 63452936
Blood pressure increased 35.20 13.18 180 34953 161882 63292007
Hepatic enzyme increased 35.20 13.18 36 35097 202292 63251597
Cardiac failure 35.19 13.18 119 35014 89023 63364866
Pancreatic carcinoma 35.04 13.18 31 35102 7597 63446292
Blister 34.99 13.18 14 35119 129800 63324089
Inappropriate antidiuretic hormone secretion 33.40 13.18 42 35091 15420 63438469
Rash 33.10 13.18 179 34954 560692 62893197
Urine output decreased 33.10 13.18 36 35097 11334 63442555
Palpitations 32.43 13.18 136 34997 112634 63341255
Atrioventricular block first degree 32.30 13.18 29 35104 7244 63446645
Alopecia 31.94 13.18 89 35044 337447 63116442
Blood lactic acid 31.31 13.18 8 35125 99 63453790
Muscle atrophy 31.15 13.18 28 35105 7005 63446884
Blood pressure systolic increased 31.12 13.18 76 35057 47321 63406568
Vulvovaginal candidiasis 30.41 13.18 20 35113 3155 63450734
Metastases to fallopian tube 30.26 13.18 7 35126 55 63453834
Syncope 29.52 13.18 136 34997 117249 63336640
Blood cholesterol increased 29.08 13.18 8 35125 94024 63359865
Joint noise 28.90 13.18 22 35111 4370 63449519
Therapy non-responder 28.62 13.18 4 35129 75897 63377992
Pruritus genital 28.58 13.18 18 35115 2636 63451253
Osteoporosis 28.58 13.18 83 35050 57255 63396634
Cardiospasm 28.56 13.18 16 35117 1891 63451998
Rhinorrhoea 28.08 13.18 90 35043 65487 63388402
Fall 28.05 13.18 336 34797 391998 63061891
Bladder sphincter atony 27.88 13.18 8 35125 157 63453732
Therapeutic reaction time decreased 27.87 13.18 17 35116 2353 63451536
Palmoplantar keratoderma 27.80 13.18 16 35117 1991 63451898
Faeces discoloured 27.53 13.18 42 35091 18467 63435422
Irritable bowel syndrome 27.46 13.18 6 35127 82406 63371483
Swelling 27.26 13.18 71 35062 275307 63178582
Hand deformity 27.02 13.18 29 35104 159428 63294461
Hypotension 26.78 13.18 249 34884 272355 63181534
Neuroglycopenia 26.59 13.18 10 35123 468 63453421
Abdominal discomfort 26.52 13.18 90 35043 320795 63133094
Glucose urine present 25.72 13.18 11 35122 721 63453168
Cardiac arrest 25.36 13.18 110 35023 92435 63361454
Carcinoid tumour 24.77 13.18 9 35124 382 63453507
Fear-related avoidance of activities 24.75 13.18 7 35126 130 63453759
Acetonaemia 24.75 13.18 7 35126 130 63453759
Insulin-like growth factor decreased 24.66 13.18 9 35124 387 63453502
Adverse event 24.46 13.18 4 35129 67555 63386334
Autoimmune nephritis 24.10 13.18 9 35124 413 63453476
Sensory loss 24.03 13.18 29 35104 10209 63443680
Head injury 23.66 13.18 49 35084 27347 63426542
Sleep terror 23.54 13.18 16 35117 2664 63451225
Vomiting 23.42 13.18 437 34696 559180 62894709
Neutropenia 23.34 13.18 38 35095 174967 63278922
Adjustment disorder 23.33 13.18 17 35116 3161 63450728
Bradycardia 23.18 13.18 91 35042 73136 63380753
Joint swelling 23.12 13.18 98 35035 327568 63126321
Blood cholesterol decreased 23.04 13.18 11 35122 933 63452956
Steatorrhoea 22.63 13.18 9 35124 490 63453399
Aspartate aminotransferase increased 22.33 13.18 11 35122 90266 63363623
Rebound psychosis 22.21 13.18 7 35126 191 63453698
Hypovolaemic shock 22.19 13.18 22 35111 6219 63447670
Affect lability 22.06 13.18 29 35104 11122 63442767
Serum serotonin increased 21.97 13.18 7 35126 198 63453691
Drug hypersensitivity 21.87 13.18 93 35040 310594 63143295
Impaired healing 21.81 13.18 15 35118 102527 63351362
Hepatic pain 21.65 13.18 16 35117 3040 63450849
Cardiogenic shock 21.63 13.18 37 35096 17895 63435994
Diabetes mellitus 21.57 13.18 74 35059 55736 63398153
Metastases to bladder 21.42 13.18 7 35126 215 63453674
Cardioactive drug level increased 21.41 13.18 14 35119 2186 63451703
Sneezing 21.20 13.18 37 35096 18181 63435708
Urine calcium/creatinine ratio increased 21.09 13.18 6 35127 114 63453775
Head discomfort 20.74 13.18 31 35102 13384 63440505
Cognitive disorder 20.70 13.18 73 35060 55742 63398147
Immunisation 20.61 13.18 11 35122 1182 63452707
Cough 20.58 13.18 250 34883 292493 63161396
Therapeutic product effect decreased 20.52 13.18 48 35085 193139 63260750
Meningioma 20.31 13.18 17 35116 3868 63450021
Fatigue 20.27 13.18 358 34775 887670 62566219
Carcinoid crisis 20.18 13.18 7 35126 259 63453630
Endometrial cancer stage I 20.16 13.18 7 35126 260 63453629
Gastric polyps 20.11 13.18 16 35117 3389 63450500
Pericarditis 20.07 13.18 26 35107 131553 63322336
Chorea 20.00 13.18 12 35121 1612 63452277
Constipation 19.88 13.18 201 34932 224742 63229147
Transplant rejection 19.74 13.18 27 35106 10753 63443136
Condition aggravated 19.69 13.18 136 34997 402081 63051808
Hemiplegia 19.62 13.18 25 35108 9298 63444591
Polydipsia 19.47 13.18 16 35117 3548 63450341
Muscle injury 19.40 13.18 6 35127 65339 63388550
Trichophytosis 19.27 13.18 5 35128 66 63453823
Wrong patient received product 18.97 13.18 13 35120 2194 63451695
Upper respiratory tract infection 18.83 13.18 11 35122 82036 63371853
Sinus congestion 18.78 13.18 35 35098 18088 63435801
Delayed graft function 18.66 13.18 10 35123 1083 63452806
Crystal arthropathy 18.59 13.18 7 35126 329 63453560
Salivary hypersecretion 18.46 13.18 22 35111 7644 63446245
Renal impairment 18.38 13.18 97 35036 88258 63365631
Base excess decreased 18.15 13.18 5 35128 84 63453805
Urethral caruncle 18.15 13.18 5 35128 84 63453805
Fibromyalgia 18.14 13.18 11 35122 80409 63373480
Diabetic hyperosmolar coma 17.93 13.18 7 35126 363 63453526
Tension headache 17.92 13.18 18 35115 5168 63448721
Blood glucose fluctuation 17.91 13.18 17 35116 4559 63449330
White blood cell count decreased 17.81 13.18 31 35102 139073 63314816
Endometrial hyperplasia 17.74 13.18 9 35124 871 63453018
Hypomagnesaemia 17.72 13.18 45 35088 28692 63425197
Carotid artery occlusion 17.54 13.18 17 35116 4677 63449212
Urine ketone body present 17.50 13.18 13 35120 2490 63451399
Calculus bladder 17.45 13.18 8 35125 619 63453270
Electrocardiogram T wave peaked 17.43 13.18 6 35127 217 63453672
Tinnitus 17.20 13.18 51 35082 35577 63418312
Atrial tachycardia 17.07 13.18 16 35117 4224 63449665
Cholestatic liver injury 17.01 13.18 13 35120 2597 63451292
Blood phosphorus increased 16.93 13.18 14 35119 3131 63450758
Somnolence 16.92 13.18 162 34971 178523 63275366
Contraindicated product prescribed 16.86 13.18 10 35123 1315 63452574
Full blood count abnormal 16.86 13.18 47 35086 31670 63422219
Abdominal adhesions 16.79 13.18 14 35119 3168 63450721
Muscle neoplasm 16.71 13.18 4 35129 37 63453852
Diarrhoea 16.56 13.18 515 34618 714851 62739038
Gallbladder neoplasm 16.52 13.18 4 35129 39 63453850
Metastases to ovary 16.48 13.18 7 35126 451 63453438
Blood glucose decreased 16.39 13.18 36 35097 20916 63432973
Diabetic ketosis 16.18 13.18 6 35127 270 63453619
Lymphatic system neoplasm 16.17 13.18 4 35129 43 63453846
Bite 16.15 13.18 7 35126 474 63453415
Coordination abnormal 16.06 13.18 28 35105 13745 63440144
Thirst decreased 16.01 13.18 6 35127 278 63453611
Rhabdomyolysis 15.88 13.18 57 35076 43894 63409995
Thrombosis 15.85 13.18 8 35125 64747 63389142
Blood ketone body increased 15.69 13.18 6 35127 294 63453595
Injection site pruritus 15.62 13.18 3 35130 45113 63408776
Anaphylactic reaction 15.45 13.18 75 35058 66025 63387864
Initial insomnia 15.37 13.18 18 35115 6139 63447750
Haemodynamic instability 15.31 13.18 22 35111 9168 63444721
Muscular weakness 15.29 13.18 118 35015 122235 63331654
Adverse drug reaction 15.24 13.18 13 35120 79701 63374188
Injury 15.20 13.18 11 35122 73236 63380653
Stupor 15.07 13.18 15 35118 4260 63449629
Hypomenorrhoea 14.99 13.18 7 35126 565 63453324
Nasal congestion 14.99 13.18 74 35059 65586 63388303
Ill-defined disorder 14.83 13.18 14 35119 81741 63372148
Unevaluable event 14.75 13.18 5 35128 51381 63402508
Drug dependence 14.75 13.18 38 35095 24445 63429444
Hypokinesia 14.55 13.18 27 35106 13909 63439980
Body height increased 14.48 13.18 4 35129 68 63453821
Photosensitivity reaction 14.36 13.18 28 35105 14966 63438923
Peptic ulcer 14.19 13.18 15 35118 4572 63449317
Pain of skin 14.02 13.18 24 35109 11610 63442279
Hyperglycaemic hyperosmolar nonketotic syndrome 14.01 13.18 8 35125 981 63452908
Pyrexia 13.64 13.18 181 34952 470297 62983592
Hepatic failure 13.54 13.18 47 35086 35609 63418280
Abdominal pain upper 13.50 13.18 174 34959 206270 63247619
Incision site swelling 13.46 13.18 5 35128 226 63453663
Breast cancer 13.39 13.18 5 35128 48378 63405511
Poisoning deliberate 13.34 13.18 23 35110 11195 63442694
Scoliosis 13.31 13.18 19 35114 7869 63446020
Labelled drug-drug interaction issue 13.21 13.18 8 35125 1093 63452796

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 460.69 12.30 385 30850 54255 34871441
Acute kidney injury 356.24 12.30 816 30419 304172 34621524
Lactic acidosis 307.34 12.30 252 30983 34520 34891176
Diabetes mellitus inadequate control 284.72 12.30 167 31068 13297 34912399
Diabetic ketoacidosis 280.67 12.30 184 31051 17848 34907848
Hyperkalaemia 168.20 12.30 255 30980 69134 34856562
Diabetic metabolic decompensation 131.36 12.30 52 31183 1714 34923982
Euglycaemic diabetic ketoacidosis 104.30 12.30 53 31182 3169 34922527
Metabolic acidosis 102.19 12.30 158 31077 43522 34882174
Hyperglycaemia 96.85 12.30 146 31089 39334 34886362
Hyperlactacidaemia 87.24 12.30 46 31189 2970 34922726
Soft tissue mass 79.29 12.30 31 31204 988 34924708
Glycosylated haemoglobin increased 79.27 12.30 72 31163 11288 34914408
Multimorbidity 78.06 12.30 30 31205 912 34924784
Oesophageal perforation 77.79 12.30 32 31203 1167 34924529
Death 75.12 12.30 152 31083 397897 34527799
Completed suicide 71.48 12.30 4 31231 98164 34827532
Rales 61.93 12.30 59 31176 9824 34915872
Pemphigoid 56.72 12.30 53 31182 8613 34917083
Superinfection 55.21 12.30 32 31203 2487 34923209
Drug abuse 54.70 12.30 11 31224 99085 34826611
Type 2 diabetes mellitus 53.85 12.30 69 31166 15963 34909733
Liver palpable 49.91 12.30 16 31219 280 34925416
Lower respiratory tract infection 49.71 12.30 96 31139 31541 34894155
Hepatic vein dilatation 49.44 12.30 15 31220 217 34925479
Drug interaction 48.77 12.30 357 30878 225589 34700107
Foetal disorder 46.73 12.30 20 31215 806 34924890
Blood glucose increased 46.32 12.30 148 31087 66570 34859126
Obesity 45.75 12.30 57 31178 12821 34912875
Product dose omission issue 45.73 12.30 25 31210 119686 34806010
Transplant failure 45.13 12.30 32 31203 3521 34922175
Pancreatitis acute 43.73 12.30 85 31150 28056 34897640
Immunosuppressant drug level increased 43.46 12.30 39 31196 6016 34919680
Hypoglycaemic coma 43.23 12.30 27 31208 2404 34923292
Dermatitis bullous 42.75 12.30 41 31194 6881 34918815
Lumbosacral radiculoplexus neuropathy 40.57 12.30 9 31226 32 34925664
Atrial enlargement 40.44 12.30 17 31218 655 34925041
Neutropenia neonatal 39.49 12.30 17 31218 695 34925001
Low density lipoprotein abnormal 39.42 12.30 14 31221 339 34925357
Inflammatory marker increased 39.32 12.30 34 31201 4994 34920702
Obstructive pancreatitis 38.77 12.30 16 31219 588 34925108
Ureteric compression 38.61 12.30 13 31222 267 34925429
Inferior vena cava dilatation 38.43 12.30 17 31218 743 34924953
Disease progression 36.53 12.30 26 31209 108051 34817645
Myocardial ischaemia 35.24 12.30 59 31176 17349 34908347
Malaise 34.70 12.30 284 30951 185541 34740155
Lung consolidation 34.49 12.30 34 31201 5902 34919794
Right ventricular dysfunction 34.19 12.30 18 31217 1158 34924538
Cardiac failure 32.96 12.30 165 31070 91083 34834613
Platelet count decreased 32.95 12.30 35 31200 119682 34806014
Fibrillary glomerulonephritis 32.94 12.30 8 31227 46 34925650
Hepatojugular reflux 32.19 12.30 14 31221 587 34925109
Oesophageal carcinoma 31.17 12.30 40 31195 9264 34916432
Ventricular enlargement 30.85 12.30 14 31221 650 34925046
Distributive shock 30.36 12.30 17 31218 1237 34924459
Dyspnoea at rest 30.17 12.30 26 31209 3802 34921894
Spleen congestion 29.61 12.30 11 31224 304 34925392
Drug ineffective 29.46 12.30 264 30971 456487 34469209
Mouth swelling 29.00 12.30 19 31216 1837 34923859
Cardiac failure chronic 28.18 12.30 35 31200 7844 34917852
Cholestasis 27.75 12.30 69 31166 26879 34898817
Neuromyopathy 27.74 12.30 15 31220 1019 34924677
Pain 27.12 12.30 93 31142 204582 34721114
Weight increased 26.69 12.30 158 31077 92875 34832821
Flour sensitivity 26.49 12.30 6 31229 24 34925672
Dental caries 26.37 12.30 26 31209 4513 34921183
Productive cough 26.33 12.30 84 31151 37729 34887967
Urinary tract discomfort 26.10 12.30 8 31227 120 34925576
Helicobacter test false negative 26.09 12.30 7 31228 63 34925633
Pyonephrosis 25.99 12.30 7 31228 64 34925632
Cardiomegaly 25.67 12.30 48 31187 15390 34910306
Ketonuria 25.63 12.30 12 31223 599 34925097
Microsporum infection 25.40 12.30 6 31229 30 34925666
Drug level increased 25.36 12.30 59 31176 22037 34903659
Pancreatic carcinoma metastatic 25.29 12.30 21 31214 2919 34922777
Spondylolysis 25.16 12.30 7 31228 73 34925623
Blood pressure increased 24.87 12.30 149 31086 87953 34837743
Herbal interaction 24.19 12.30 10 31225 369 34925327
Dust allergy 23.90 12.30 13 31222 893 34924803
Intercapillary glomerulosclerosis 23.81 12.30 6 31229 41 34925655
Renal impairment 23.66 12.30 155 31080 94358 34831338
Food aversion 23.00 12.30 10 31225 419 34925277
White blood cell count decreased 22.96 12.30 31 31204 95414 34830282
Hemiparaesthesia 22.77 12.30 7 31228 106 34925590
Asthma-chronic obstructive pulmonary disease overlap syndrome 22.14 12.30 14 31221 1273 34924423
Hypohidrosis 21.85 12.30 8 31227 212 34925484
Hypoosmolar state 21.70 12.30 7 31228 125 34925571
Thrombosis 21.60 12.30 9 31226 50449 34875247
Haematoma muscle 21.36 12.30 14 31221 1354 34924342
Peak expiratory flow rate decreased 21.35 12.30 7 31228 132 34925564
Suspected suicide attempt 21.25 12.30 7 31228 134 34925562
Pyelocaliectasis 21.23 12.30 13 31222 1117 34924579
Wrong patient received product 20.86 12.30 18 31217 2636 34923060
Cardiac ventricular disorder 20.52 12.30 8 31227 253 34925443
Pancreatic carcinoma 20.51 12.30 32 31203 8869 34916827
Stenosis 20.42 12.30 14 31221 1459 34924237
Bronchitis viral 20.37 12.30 8 31227 258 34925438
Febrile neutropenia 20.35 12.30 59 31176 136790 34788906
Acetonaemia 20.21 12.30 7 31228 157 34925539
Genital swelling 20.05 12.30 7 31228 161 34925535
Skin ulcer 19.91 12.30 54 31181 22162 34903534
Hyperglycaemic hyperosmolar nonketotic syndrome 19.75 12.30 13 31222 1267 34924429
Anal fistula 19.34 12.30 24 31211 5375 34920321
Left ventricular dysfunction 19.04 12.30 33 31202 9974 34915722
Metastases to pelvis 19.01 12.30 8 31227 309 34925387
Cockroach allergy 18.84 12.30 5 31230 43 34925653
Mycetoma mycotic 18.82 12.30 6 31229 103 34925593
Ketoacidosis 18.74 12.30 21 31214 4222 34921474
Autoimmune pancreatitis 18.59 12.30 8 31227 327 34925369
Off label use 18.50 12.30 264 30971 419260 34506436
Vitamin D deficiency 18.45 12.30 26 31209 6582 34919114
Aspartate aminotransferase increased 18.43 12.30 20 31215 67763 34857933
Therapy non-responder 18.41 12.30 6 31229 39140 34886556
Capillary fragility 18.35 12.30 5 31230 48 34925648
Depression 18.27 12.30 37 31198 97061 34828635
Application site haematoma 18.25 12.30 5 31230 49 34925647
Blood pressure systolic increased 17.85 12.30 53 31182 22899 34902797
Generalised oedema 17.50 12.30 36 31199 12372 34913324
Blood pressure diastolic increased 17.46 12.30 22 31213 5003 34920693
Forced vital capacity decreased 17.38 12.30 10 31225 766 34924930
Melaena 17.28 12.30 70 31165 35310 34890386
Latent autoimmune diabetes in adults 17.26 12.30 5 31230 61 34925635
Oxygen saturation decreased 17.13 12.30 94 31141 53724 34871972
Tongue haemorrhage 17.07 12.30 9 31226 581 34925115
Mast cell degranulation present 16.76 12.30 5 31230 68 34925628
Dysmetria 16.76 12.30 9 31226 603 34925093
Adverse drug reaction 16.72 12.30 3 31232 29339 34896357
Orbital oedema 16.53 12.30 6 31229 155 34925541
Cholestatic liver injury 16.52 12.30 15 31220 2349 34923347
Mental status changes 15.97 12.30 7 31228 38076 34887620
Conjunctival disorder 15.84 12.30 5 31230 83 34925613
Neutrophilia 15.80 12.30 19 31216 4118 34921578
Heart rate irregular 15.78 12.30 40 31195 15767 34909929
Sopor 15.71 12.30 34 31201 12102 34913594
Intentional product misuse 15.36 12.30 11 31224 45600 34880096
Unevaluable event 15.32 12.30 5 31230 32585 34893111
Hospitalisation 15.24 12.30 17 31218 56885 34868811
Gastric dilatation 15.22 12.30 9 31226 726 34924970
Anion gap increased 15.19 12.30 13 31222 1883 34923813
Neutrophil count decreased 15.13 12.30 14 31221 51090 34874606
Jaundice cholestatic 15.11 12.30 20 31215 4774 34920922
Bradycardia 14.98 12.30 117 31118 75301 34850395
Basosquamous carcinoma 14.97 12.30 5 31230 100 34925596
Tonic clonic movements 14.88 12.30 10 31225 1009 34924687
Heart rate 14.71 12.30 4 31231 38 34925658
Hyperaesthesia teeth 14.65 12.30 8 31227 554 34925142
Hyperintensity in brain deep nuclei 14.61 12.30 5 31230 108 34925588
Complex regional pain syndrome 14.58 12.30 8 31227 559 34925137
Mycobacterial infection 14.54 12.30 14 31221 2360 34923336
Gastric varices 14.52 12.30 8 31227 564 34925132
Plasma cell myeloma 14.34 12.30 10 31225 42027 34883669
Hypercholesterolaemia 14.26 12.30 27 31208 8735 34916961
Cytomegalovirus infection 14.20 12.30 3 31232 26132 34899564
Procedural haemorrhage 14.14 12.30 14 31221 2443 34923253
Lipase increased 14.09 12.30 28 31207 9388 34916308
Exercise tolerance decreased 13.85 12.30 20 31215 5178 34920518
Urine ketone body present 13.80 12.30 10 31225 1138 34924558
Antipsychotic drug level increased 13.55 12.30 17 31218 3848 34921848
Pancreatic neoplasm 13.47 12.30 9 31226 899 34924797
Fatigue 13.39 12.30 242 30993 370411 34555285
Chorioretinitis 13.39 12.30 7 31228 444 34925252
Hepatocellular injury 13.38 12.30 47 31188 22164 34903532
Immunoglobulin G4 related disease 13.26 12.30 5 31230 144 34925552
Traumatic shock 13.05 12.30 3 31232 13 34925683
Right ventricular dilatation 13.01 12.30 8 31227 693 34925003
Microalbuminuria 13.00 12.30 8 31227 694 34925002
Seizure 12.96 12.30 49 31186 104808 34820888
Arthropathy 12.88 12.30 4 31231 26903 34898793
Incarcerated hernia 12.86 12.30 5 31230 157 34925539
Ejection fraction decreased 12.83 12.30 42 31193 19112 34906584
Adrenal cyst 12.83 12.30 5 31230 158 34925538
Ketosis 12.74 12.30 7 31228 491 34925205
Thrombocytosis 12.72 12.30 17 31218 4095 34921601
Product use in unapproved indication 12.61 12.30 58 31177 117441 34808255
Urogenital infection fungal 12.54 12.30 3 31232 16 34925680
Thrombocytopenia 12.48 12.30 85 31150 156162 34769534
Diabetic neuropathy 12.45 12.30 17 31218 4180 34921516
Abnormal weight gain 12.41 12.30 9 31226 1025 34924671
Muscle oedema 12.37 12.30 5 31230 174 34925522

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 1044.93 11.54 770 63160 100824 79579634
Lactic acidosis 839.59 11.54 584 63346 69775 79610683
Acute kidney injury 710.65 11.54 1391 62539 518013 79162445
Diabetes mellitus inadequate control 562.85 11.54 308 63622 23956 79656502
Diabetic ketoacidosis 524.83 11.54 332 63598 33790 79646668
Hyperkalaemia 347.37 11.54 443 63487 113955 79566503
Hyperglycaemia 280.38 11.54 313 63617 70022 79610436
Diabetic metabolic decompensation 225.77 11.54 89 63841 3243 79677215
Metabolic acidosis 209.57 11.54 293 63637 82236 79598222
Euglycaemic diabetic ketoacidosis 204.60 11.54 103 63827 6741 79673717
Glycosylated haemoglobin increased 168.95 11.54 133 63797 19127 79661331
Completed suicide 160.53 11.54 9 63921 245758 79434700
Hypoglycaemic coma 155.21 11.54 76 63854 4684 79675774
Hyperlactacidaemia 143.60 11.54 76 63854 5519 79674939
Pemphigoid 124.18 11.54 101 63829 15214 79665244
Malignant mediastinal neoplasm 114.46 11.54 43 63887 1372 79679086
Blood glucose increased 111.53 11.54 269 63661 114706 79565752
Pancreatitis acute 106.83 11.54 163 63767 49441 79631017
Ketoacidosis 102.52 11.54 69 63861 7785 79672673
Drug interaction 94.20 11.54 612 63318 414571 79265887
Arthropathy 93.40 11.54 15 63915 177096 79503362
Maternal exposure during pregnancy 83.30 11.54 7 63923 136531 79543927
Death 81.88 11.54 211 63719 566303 79114155
Product dose omission issue 79.70 11.54 50 63880 247487 79432971
Hyponatraemia 79.10 11.54 317 63613 177531 79502927
Gangrene 78.82 11.54 62 63868 8902 79671556
Blood immunoglobulin E increased 75.16 11.54 51 63879 5831 79674627
Multiple drug therapy 73.67 11.54 44 63886 4034 79676424
Gastric disorder 72.27 11.54 117 63813 37316 79643142
Soft tissue mass 72.11 11.54 30 63900 1258 79679200
Oesophageal perforation 69.57 11.54 31 63899 1540 79678918
Drug abuse 69.36 11.54 22 63908 162669 79517789
Pain 69.08 11.54 310 63620 703492 78976966
Cardiac failure 68.85 11.54 276 63654 154566 79525892
Loss of employment 68.83 11.54 36 63894 2551 79677907
Glossodynia 66.77 11.54 4 63926 103333 79577125
Multimorbidity 65.67 11.54 29 63901 1410 79679048
Arterial occlusive disease 64.85 11.54 54 63876 8402 79672056
Malaise 64.29 11.54 637 63293 489232 79191226
Melaena 62.84 11.54 146 63784 60744 79619714
Synovitis 61.44 11.54 22 63908 150712 79529746
Drug ineffective 58.48 11.54 570 63360 1080343 78600115
Exposure during pregnancy 56.97 11.54 7 63923 101125 79579333
Pancreatic carcinoma 56.77 11.54 62 63868 13515 79666943
Pemphigus 55.84 11.54 7 63923 99575 79580883
Stomatitis 52.47 11.54 26 63904 146731 79533727
Blood pressure increased 51.81 11.54 318 63612 211042 79469416
Treatment failure 50.11 11.54 38 63892 170448 79510010
Hepatic vein dilatation 50.05 11.54 15 63915 233 79680225
Hypersensitivity 49.30 11.54 84 63846 262155 79418303
Liver palpable 48.49 11.54 16 63914 345 79680113
Inflammatory marker increased 46.58 11.54 50 63880 10690 79669768
Dermatitis bullous 46.07 11.54 57 63873 14188 79666270
Therapy non-responder 46.07 11.54 9 63921 92296 79588162
White blood cell count decreased 44.69 11.54 51 63879 188237 79492221
Infusion related reaction 43.96 11.54 73 63857 230164 79450294
Discomfort 43.79 11.54 23 63907 125594 79554864
Aspartate aminotransferase increased 43.24 11.54 29 63901 138612 79541846
Obesity 41.61 11.54 89 63841 35036 79645422
Helicobacter infection 41.35 11.54 4 63926 69700 79610758
Acetonaemia 41.34 11.54 14 63916 328 79680130
Superinfection 41.16 11.54 33 63897 4869 79675589
Wound 40.90 11.54 21 63909 116158 79564300
Obstructive pancreatitis 40.82 11.54 18 63912 872 79679586
Rales 40.64 11.54 64 63866 19937 79660521
Ureteric compression 39.86 11.54 13 63917 270 79680188
Disease progression 39.50 11.54 54 63876 184308 79496150
Hepatic steatosis 39.50 11.54 91 63839 37647 79642811
Renal impairment 39.03 11.54 238 63692 157545 79522913
Exercise tolerance decreased 38.93 11.54 42 63888 9029 79671429
Tubulointerstitial nephritis 38.70 11.54 91 63839 38144 79642314
Transplant failure 38.45 11.54 31 63899 4610 79675848
Atrial enlargement 38.09 11.54 18 63912 1025 79679433
Inferior vena cava dilatation 37.97 11.54 17 63913 854 79679604
Bronchiectasis 37.91 11.54 66 63864 22320 79658138
Low density lipoprotein abnormal 37.31 11.54 14 63916 445 79680013
Hepatic enzyme increased 36.65 11.54 56 63874 182554 79497904
Wrong patient received product 36.48 11.54 30 63900 4588 79675870
Blood pressure inadequately controlled 36.46 11.54 34 63896 6143 79674315
Urinary retention 36.40 11.54 114 63816 56516 79623942
Lumbosacral radiculoplexus neuropathy 36.14 11.54 9 63921 66 79680392
Platelet count decreased 35.98 11.54 63 63867 194601 79485857
Immunosuppressant drug level increased 35.63 11.54 40 63890 8987 79671471
Butterfly rash 35.13 11.54 20 63910 1676 79678782
Atrioventricular block first degree 34.16 11.54 46 63884 12445 79668013
Injury 33.88 11.54 10 63920 77486 79602972
Neutropenia 33.67 11.54 118 63812 287592 79392866
Acne 33.48 11.54 70 63860 27120 79653338
Folliculitis 33.33 11.54 3 63927 55377 79625081
Bradycardia 33.22 11.54 204 63726 135353 79545105
Blood pressure systolic increased 32.67 11.54 123 63807 66863 79613595
Hepatojugular reflux 32.64 11.54 14 63916 634 79679824
Fibrillary glomerulonephritis 32.57 11.54 8 63922 55 79680403
Mental status changes 32.44 11.54 7 63923 66952 79613506
Drug level increased 32.41 11.54 87 63843 39564 79640894
Neurologic neglect syndrome 31.99 11.54 23 63907 2884 79677574
Pneumonia aspiration 31.87 11.54 122 63808 66845 79613613
Cataract 31.08 11.54 115 63815 62005 79618453
Ventricular enlargement 31.00 11.54 14 63916 718 79679740
Carotid artery thrombosis 30.98 11.54 23 63907 3030 79677428
Pancreatic carcinoma metastatic 30.95 11.54 25 63905 3728 79676730
Cholestatic liver injury 30.73 11.54 28 63902 4913 79675545
Genital swelling 30.27 11.54 11 63919 319 79680139
Adverse event 29.78 11.54 6 63924 60208 79620250
Blood cholesterol decreased 29.58 11.54 18 63912 1707 79678751
Angina pectoris 29.51 11.54 100 63830 51632 79628826
Hyperglycaemic hyperosmolar nonketotic syndrome 29.50 11.54 20 63910 2283 79678175
Glucose urine present 29.28 11.54 18 63912 1738 79678720
Alopecia 29.04 11.54 92 63838 231263 79449195
Mesenteric panniculitis 28.62 11.54 11 63919 374 79680084
Pyonephrosis 28.60 11.54 8 63922 96 79680362
Thrombosis 28.43 11.54 16 63914 84084 79596374
Skin haemorrhage 28.12 11.54 41 63889 11940 79668518
Vulvovaginal candidiasis 27.92 11.54 20 63910 2494 79677964
Urine ketone body present 27.83 11.54 23 63907 3542 79676916
Peripheral circulatory failure 27.81 11.54 15 63915 1131 79679327
Metastases to fallopian tube 27.68 11.54 7 63923 55 79680403
Therapeutic product effect decreased 27.66 11.54 56 63874 163807 79516651
Oesophageal carcinoma 27.58 11.54 39 63891 11045 79669413
Drug hypersensitivity 27.25 11.54 135 63795 298781 79381677
Myocardial ischaemia 27.21 11.54 62 63868 25457 79655001
Cardioactive drug level increased 27.03 11.54 23 63907 3686 79676772
Parkinsonism 26.93 11.54 48 63882 16536 79663922
Fibromyalgia 26.88 11.54 9 63921 64331 79616127
Spleen congestion 26.86 11.54 11 63919 443 79680015
Helicobacter test false negative 26.84 11.54 7 63923 63 79680395
Polymyalgia rheumatica 26.83 11.54 25 63905 4512 79675946
Blood cholesterol increased 26.79 11.54 17 63913 83703 79596755
Unevaluable event 26.54 11.54 6 63924 55579 79624879
Impaired healing 26.44 11.54 19 63911 87636 79592822
Infection 26.39 11.54 102 63828 241610 79438848
Dust allergy 26.26 11.54 16 63914 1520 79678938
Pericarditis 26.09 11.54 27 63903 104209 79576249
Neuromyopathy 26.05 11.54 16 63914 1542 79678916
Neutrophilia 26.01 11.54 32 63898 7919 79672539
Cardiac failure chronic 25.98 11.54 38 63892 11097 79669361
Inappropriate antidiuretic hormone secretion 25.95 11.54 62 63868 26251 79654207
Product use in unapproved indication 25.23 11.54 109 63821 250250 79430208
Bite 24.94 11.54 11 63919 533 79679925
Head discomfort 24.88 11.54 43 63887 14459 79665999
Pyelocaliectasis 24.87 11.54 13 63917 920 79679538
Injection site erythema 24.86 11.54 16 63914 78181 79602277
Joint swelling 24.82 11.54 133 63797 288513 79391945
Hand deformity 24.80 11.54 28 63902 103891 79576567
Pyrexia 24.76 11.54 389 63541 678320 79002138
Carcinoid tumour 24.69 11.54 11 63919 546 79679912
Periorbital oedema 24.61 11.54 32 63898 8370 79672088
Lung consolidation 24.54 11.54 33 63897 8914 79671544
Diabetes mellitus 24.52 11.54 126 63804 78264 79602194
Multiple sclerosis relapse 24.38 11.54 4 63926 46529 79633929
Ketonuria 24.37 11.54 14 63916 1194 79679264
Thrombocytosis 24.24 11.54 32 63898 8494 79671964
Microsporum infection 24.09 11.54 6 63924 44 79680414
Medication error 24.09 11.54 114 63816 68528 79611930
Fatigue 24.09 11.54 565 63365 929162 78751296
Neutrophil count decreased 23.90 11.54 24 63906 93935 79586523
Faeces discoloured 23.89 11.54 64 63866 29063 79651395
Personality disorder 23.86 11.54 27 63903 6119 79674339
Irritable bowel syndrome 23.84 11.54 10 63920 62231 79618227
Fear-related avoidance of activities 23.77 11.54 7 63923 102 79680356
Blood glucose fluctuation 23.67 11.54 28 63902 6654 79673804
Upper respiratory tract infection 23.52 11.54 23 63907 91145 79589313
Dyspnoea at rest 23.26 11.54 29 63901 7273 79673185
Condition aggravated 23.02 11.54 274 63656 500850 79179608
Neuroglycopenia 22.88 11.54 10 63920 474 79679984
Blister 22.68 11.54 38 63892 119438 79561020
Flour sensitivity 22.62 11.54 5 63925 20 79680438
Febrile neutropenia 22.41 11.54 102 63828 230897 79449561
Distributive shock 22.37 11.54 18 63912 2669 79677789
Herbal interaction 22.34 11.54 10 63920 502 79679956
Polydipsia 22.28 11.54 27 63903 6578 79673880
Spondylolysis 21.95 11.54 7 63923 135 79680323
Toxicity to various agents 21.93 11.54 224 63706 421316 79259142
Transplant dysfunction 21.93 11.54 28 63902 7193 79673265
Intercapillary glomerulosclerosis 21.92 11.54 6 63924 66 79680392
Motor dysfunction 21.84 11.54 41 63889 14692 79665766
Open reduction of fracture 21.36 11.54 8 63922 253 79680205
Insulin-like growth factor decreased 21.07 11.54 10 63920 575 79679883
Loss of personal independence in daily activities 21.01 11.54 31 63899 102549 79577909
Lipase increased 20.99 11.54 43 63887 16423 79664035
Diabetic nephropathy 20.92 11.54 18 63912 2929 79677529
Bronchitis 20.91 11.54 46 63884 130598 79549860
Respiratory arrest 20.86 11.54 10 63920 57540 79622918
Alanine aminotransferase increased 20.85 11.54 64 63866 162506 79517952
Hypotension 20.64 11.54 480 63450 439837 79240621
Food aversion 20.59 11.54 12 63918 1051 79679407
Haemoglobin increased 20.58 11.54 25 63905 6107 79674351
Right ventricular dysfunction 20.57 11.54 17 63913 2618 79677840
Adverse drug reaction 20.54 11.54 14 63916 66378 79614080
Meningioma 20.40 11.54 21 63909 4277 79676181
Hypohidrosis 20.36 11.54 8 63922 289 79680169
Blood glucose abnormal 20.35 11.54 33 63897 10533 79669925
Head injury 20.24 11.54 71 63859 37298 79643160
Muscle atrophy 20.18 11.54 34 63896 11198 79669260
Therapeutic reaction time decreased 20.15 11.54 19 63911 3482 79676976
Acute coronary syndrome 19.99 11.54 49 63881 21084 79659374
Joint noise 19.93 11.54 20 63910 3954 79676504
Muscle injury 19.93 11.54 7 63923 48554 79631904
Bone marrow failure 19.91 11.54 8 63922 51099 79629359
Cardiogenic shock 19.64 11.54 76 63854 41838 79638620
Endometrial cancer stage I 19.63 11.54 7 63923 192 79680266
Cockroach allergy 19.57 11.54 6 63924 101 79680357
Renal tubular disorder 19.46 11.54 25 63905 6461 79673997
Urine output decreased 19.46 11.54 44 63886 17978 79662480
Diabetic ketosis 19.40 11.54 9 63921 491 79679967
Pancreatic neoplasm 19.34 11.54 13 63917 1463 79678995
Renal failure 19.28 11.54 246 63684 200722 79479736
Crystal arthropathy 19.10 11.54 7 63923 208 79680250
Sensory loss 19.07 11.54 36 63894 12955 79667503
Diarrhoea 19.04 11.54 875 63055 879614 78800844
General physical health deterioration 18.89 11.54 136 63794 275102 79405356
Acidosis 18.88 11.54 46 63884 19716 79660742
Cardiac ventricular disorder 18.74 11.54 8 63922 358 79680100
Infected dermal cyst 18.73 11.54 12 63918 1246 79679212
Cholestasis 18.62 11.54 87 63843 52022 79628436
Rebound psychosis 18.57 11.54 8 63922 366 79680092
Hemiparaesthesia 18.35 11.54 7 63923 233 79680225
Intentional product misuse 18.31 11.54 30 63900 95135 79585323
Red blood cell sedimentation rate increased 18.22 11.54 7 63923 45935 79634523
Mycetoma mycotic 17.82 11.54 6 63924 138 79680320
Cardiomegaly 17.81 11.54 54 63876 26298 79654160
Urine calcium/creatinine ratio increased 17.66 11.54 6 63924 142 79680316
Mouth swelling 17.65 11.54 23 63907 6028 79674430
Osteoporosis 17.64 11.54 88 63842 54024 79626434
Psoriatic arthropathy 17.56 11.54 22 63908 77977 79602481
Breast cancer 17.49 11.54 3 63927 33778 79646680
Endometrial hyperplasia 17.35 11.54 9 63921 627 79679831
Mast cell degranulation present 17.30 11.54 5 63925 68 79680390
Pain of skin 17.27 11.54 37 63893 14576 79665882
Diabetic neuropathy 17.16 11.54 23 63907 6193 79674265
Metastases to bladder 17.14 11.54 7 63923 280 79680178
Application site haematoma 16.97 11.54 5 63925 73 79680385
Drug ineffective for unapproved indication 16.96 11.54 10 63920 51228 79629230
Blood lactic acid 16.94 11.54 8 63922 455 79680003
Cortisol decreased 16.93 11.54 14 63916 2158 79678300
Urethral caruncle 16.91 11.54 5 63925 74 79680384
Feeling abnormal 16.84 11.54 68 63862 159131 79521327
Glycosuria 16.84 11.54 14 63916 2174 79678284
Thrombocytopenia 16.82 11.54 134 63796 265125 79415333
Steatorrhoea 16.80 11.54 10 63920 911 79679547
Urticaria 16.66 11.54 84 63846 185117 79495341
Nocturia 16.59 11.54 35 63895 13646 79666812
Vomiting 16.44 11.54 671 63259 665157 79015301
Depression 16.43 11.54 104 63826 216686 79463772
Swelling 16.41 11.54 104 63826 216607 79463851
Diabetic retinopathy 16.26 11.54 16 63914 3090 79677368
Serum serotonin increased 16.19 11.54 7 63923 323 79680135
Autoimmune nephritis 16.08 11.54 9 63921 730 79679728
Suspected suicide attempt 16.03 11.54 7 63923 331 79680127
Latent autoimmune diabetes in adults 15.95 11.54 5 63925 91 79680367
Hypoosmolar state 15.86 11.54 7 63923 340 79680118
Productive cough 15.75 11.54 123 63807 88208 79592250
Metastases to ovary 15.67 11.54 7 63923 350 79680108
Sinus congestion 15.60 11.54 43 63887 19853 79660605
Stenosis 15.60 11.54 14 63916 2408 79678050
Osteonecrosis 15.58 11.54 3 63927 31092 79649366
Anion gap increased 15.57 11.54 17 63913 3703 79676755
Gastric polyps 15.47 11.54 17 63913 3730 79676728
Basosquamous carcinoma 15.41 11.54 5 63925 102 79680356
Rhinorrhoea 15.30 11.54 109 63821 75965 79604493
Sinusitis 15.22 11.54 93 63837 195408 79485050
Blood glucose decreased 15.22 11.54 51 63879 26183 79654275
Hypoxia 15.20 11.54 38 63892 103205 79577253
Heart rate irregular 15.11 11.54 59 63871 32620 79647838
Antipsychotic drug level increased 14.88 11.54 21 63909 5936 79674522
Haematoma muscle 14.68 11.54 14 63916 2601 79677857
Coma 14.68 11.54 134 63796 100515 79579943
Off label use 14.65 11.54 587 63343 906628 78773830
Pruritus genital 14.59 11.54 18 63912 4468 79675990
Adjustment disorder 14.56 11.54 17 63913 3983 79676475
Renal tubular atrophy 14.54 11.54 12 63918 1844 79678614
Hypomenorrhoea 14.52 11.54 7 63923 417 79680041
Vitamin D deficiency 14.46 11.54 34 63896 14245 79666213
Hospitalisation 14.42 11.54 34 63896 94202 79586256
Toxic epidermal necrolysis 14.33 11.54 9 63921 44572 79635886
Drug resistance 14.31 11.54 8 63922 42205 79638253
Microalbuminuria 14.27 11.54 9 63921 909 79679549
Plasma cell myeloma 14.25 11.54 13 63917 53246 79627212
Diabetes mellitus management 14.24 11.54 3 63927 9 79680449
Autoimmune pancreatitis 14.15 11.54 8 63922 662 79679796
Seizure 14.10 11.54 91 63839 188743 79491715
Papule 14.09 11.54 23 63907 7384 79673074
Nephrotic syndrome 14.03 11.54 29 63901 11145 79669313
Necrotising myositis 13.88 11.54 10 63920 1258 79679200
Affect lability 13.88 11.54 29 63901 11230 79669228
Hepatocellular injury 13.85 11.54 75 63855 47518 79632940
Aphasia 13.85 11.54 74 63856 46658 79633800
Muscle neoplasm 13.80 11.54 4 63926 55 79680403
Therapy interrupted 13.78 11.54 4 63926 31337 79649121
Muscle strength abnormal 13.78 11.54 6 63924 282 79680176
Accidental exposure to product 13.77 11.54 4 63926 31318 79649140
Abnormal faeces 13.71 11.54 23 63907 7548 79672910
Chorea 13.68 11.54 13 63917 2404 79678054
Blood ketone body increased 13.59 11.54 8 63922 714 79679744
Wrong technique in product usage process 13.56 11.54 24 63906 73851 79606607
Tongue haemorrhage 13.49 11.54 9 63921 1000 79679458
Palpitations 13.45 11.54 158 63772 126452 79554006
Cough 13.42 11.54 387 63543 366402 79314056
Lymphatic system neoplasm 13.42 11.54 4 63926 61 79680397
Ill-defined disorder 13.40 11.54 20 63910 65855 79614603
Gastric varices 13.40 11.54 8 63922 733 79679725
Urinary tract discomfort 13.40 11.54 8 63922 733 79679725
Thirst decreased 13.30 11.54 6 63924 307 79680151
Hypovolaemic shock 13.28 11.54 30 63900 12246 79668212
Muscle oedema 13.21 11.54 5 63925 163 79680295
Carcinoid crisis 13.13 11.54 7 63923 516 79679942
Adrenal cyst 13.12 11.54 5 63925 166 79680292
Forced vital capacity decreased 13.10 11.54 11 63919 1732 79678726
Glomerular filtration rate decreased 13.05 11.54 44 63886 22658 79657800
Migraine 13.04 11.54 32 63898 87461 79592997
Blood pressure systolic decreased 13.04 11.54 28 63902 11048 79669410
Traumatic shock 13.03 11.54 3 63927 15 79680443
Injection site reaction 12.81 11.54 15 63915 54770 79625688
Blood pressure fluctuation 12.81 11.54 95 63835 67050 79613408
Device issue 12.79 11.54 3 63927 27105 79653353
Abdominal adhesions 12.70 11.54 15 63915 3558 79676900
Hepatic pain 12.70 11.54 16 63914 4056 79676402
Lipid metabolism disorder 12.67 11.54 6 63924 343 79680115
Hypoaesthesia 12.60 11.54 88 63842 179264 79501194
Intramedullary rod insertion 12.56 11.54 5 63925 187 79680271
Hyperintensity in brain deep nuclei 12.56 11.54 5 63925 187 79680271
Prescribed underdose 12.55 11.54 4 63926 29510 79650948
Abortion spontaneous 12.55 11.54 4 63926 29503 79650955
Hyperaesthesia teeth 12.55 11.54 11 63919 1835 79678623
Dry eye 12.52 11.54 7 63923 36924 79643534
Ventricular fibrillation 12.43 11.54 5 63925 31921 79648537
Urogenital infection fungal 12.43 11.54 3 63927 19 79680439
Rash 12.40 11.54 361 63569 577997 79102461
Drug-induced liver injury 12.30 11.54 93 63837 66024 79614434
Irritability 12.30 11.54 9 63921 41135 79639323
Asthma-chronic obstructive pulmonary disease overlap syndrome 12.25 11.54 14 63916 3207 79677251
Bronchitis viral 12.20 11.54 9 63921 1174 79679284
Pyelonephritis 12.15 11.54 40 63890 20348 79660110
Capillary fragility 12.10 11.54 5 63925 206 79680252
Base excess decreased 12.10 11.54 6 63924 380 79680078
Gallbladder neoplasm 12.09 11.54 4 63926 87 79680371
Sneezing 12.07 11.54 39 63891 19644 79660814
Lipids abnormal 12.00 11.54 7 63923 614 79679844
Deep vein thrombosis 11.95 11.54 53 63877 120866 79559592
Cytokine release syndrome 11.95 11.54 7 63923 35991 79644467
Hypokinesia 11.90 11.54 38 63892 19022 79661436
Myelosuppression 11.81 11.54 9 63921 40287 79640171
Necrotising fasciitis 11.80 11.54 19 63911 6031 79674427
Headache 11.64 11.54 418 63512 653354 79027104

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BB09 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
MeSH PA D007004 Hypoglycemic Agents
CHEBI has role CHEBI:35526 antidiabetic
CHEBI has role CHEBI:48578 free radical scavengers
CHEBI has role CHEBI:90415 insulin secretagogues

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.97 acidic
pKa2 3.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 6.22 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Aldo-keto reductase family 1 member C3 Enzyme IC50 4.71 CHEMBL
Sulfonylurea receptor 2, Kir6.2 Ion channel BLOCKER Ki 5.13 WOMBAT-PK

External reference:

IDSource
N0000166470 NUI
D01599 KEGG_DRUG
C0017631 UMLSCUI
CHEBI:31654 CHEBI
GCZ PDB_CHEM_ID
CHEMBL427216 ChEMBL_ID
DB01120 DRUGBANK_ID
D005907 MESH_DESCRIPTOR_UI
3475 PUBCHEM_CID
3056 INN_ID
G4PX8C4HKV UNII
4816 RXNORM
003858 NDDF
325238000 SNOMEDCT_US
395731001 SNOMEDCT_US

Pharmaceutical products:

None