folic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1231 59-30-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • folic acid
  • acifolic
  • aspol
  • cytofol
  • folacid
  • pteroylglutamic acid
  • folate sodium
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
  • Molecular weight: 441.40
  • Formula: C19H19N7O6
  • CLOGP: -1.43
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 207.93
  • ALOGS: -3.74
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 mg O
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.43 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 75 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 9.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 52 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1946 FDA LEDERLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1658.51 10.07 4414 551218 179312 62754078
Systemic lupus erythematosus 1565.69 10.07 4692 550940 204226 62729164
Glossodynia 1374.54 10.07 4054 551578 174822 62758568
Hand deformity 1117.78 10.07 3500 552132 155957 62777433
Arthropathy 1026.17 10.07 4421 551211 230371 62703019
Completed suicide 1003.04 10.07 70 555562 145603 62787787
Maternal exposure during pregnancy 945.64 10.07 4123 551509 215939 62717451
Alopecia 942.15 10.07 5600 550032 331936 62601454
Abdominal discomfort 934.53 10.07 5384 550248 315501 62617889
Wound 924.78 10.07 3336 552296 159927 62773463
Rheumatoid arthritis 853.75 10.07 4430 551202 249389 62684001
Toxicity to various agents 728.17 10.07 655 554977 246595 62686795
Synovitis 727.63 10.07 3402 552230 183516 62749874
Pericarditis 696.43 10.07 2631 553001 128948 62804442
Anti-cyclic citrullinated peptide antibody positive 694.90 10.07 2418 553214 113794 62819596
Discomfort 679.99 10.07 3085 552547 164289 62769101
Swelling 676.88 10.07 4424 551208 270954 62662436
Contraindicated product administered 639.88 10.07 3663 551969 213985 62719405
Infusion related reaction 617.04 10.07 3967 551665 241554 62691836
Joint swelling 596.56 10.07 4900 550732 322766 62610624
Death 560.73 10.07 1561 554071 372820 62560570
Pain 521.18 10.07 9230 546402 731398 62201992
Duodenal ulcer perforation 437.54 10.07 1715 553917 85494 62847896
Rheumatoid factor positive 425.99 10.07 1663 553969 82743 62850647
Helicobacter infection 422.05 10.07 1770 553862 91015 62842375
Product use issue 420.39 10.07 3334 552298 217186 62716204
Intentional overdose 391.46 10.07 85 555547 74067 62859323
Exposure during pregnancy 380.89 10.07 2498 553134 153049 62780341
Hepatic enzyme increased 373.60 10.07 3037 552595 199291 62734099
Drug abuse 371.08 10.07 89 555543 72429 62860961
Arthralgia 335.05 10.07 6912 548720 562798 62370592
Psoriatic arthropathy 318.43 10.07 1614 554018 89906 62843484
Musculoskeletal stiffness 311.98 10.07 2717 552915 181901 62751489
Drug interaction 300.73 10.07 1014 554618 228117 62705273
Febrile neutropenia 295.23 10.07 361 555271 118088 62815302
Therapeutic product effect decreased 283.39 10.07 2758 552874 190429 62742961
Suicide attempt 262.61 10.07 102 555530 60816 62872574
Drug intolerance 262.12 10.07 3972 551660 304689 62628701
Depressed level of consciousness 239.22 10.07 122 555510 61956 62871434
Cardiac arrest 231.71 10.07 281 555351 92264 62841126
Hip arthroplasty 229.21 10.07 925 554707 46721 62886669
Malignant neoplasm progression 226.86 10.07 230 555402 81891 62851499
Overdose 226.29 10.07 413 555219 114665 62818725
Knee arthroplasty 225.62 10.07 1007 554625 53199 62880191
Disease progression 221.11 10.07 464 555168 122294 62811096
Treatment failure 220.79 10.07 2688 552944 196355 62737035
Hypersensitivity 194.27 10.07 3619 552013 289066 62644324
Rheumatic fever 190.15 10.07 815 554817 42296 62891094
Foetal exposure during pregnancy 188.15 10.07 662 554970 31300 62902090
Gestational diabetes 187.18 10.07 294 555338 8102 62925288
Impaired healing 186.19 10.07 1534 554098 101008 62832382
Sedation 177.44 10.07 59 555573 38750 62894640
Acute kidney injury 175.87 10.07 1467 554165 261948 62671442
Constipation 175.14 10.07 1200 554432 223743 62709647
Nasopharyngitis 169.74 10.07 3147 552485 251110 62682280
Nausea 166.66 10.07 5965 549667 848506 62084884
Swollen joint count increased 166.32 10.07 691 554941 35363 62898027
Electrocardiogram QT prolonged 158.48 10.07 172 555460 59358 62874032
Red blood cell sedimentation rate abnormal 154.97 10.07 452 555180 19330 62914060
Sickle cell anaemia with crisis 154.85 10.07 225 555407 5778 62927612
Folliculitis 152.17 10.07 1096 554536 69221 62864169
Neutropenia 149.74 10.07 907 554725 174098 62759292
Muscle injury 144.59 10.07 1024 554608 64321 62869069
Blister 144.21 10.07 1754 553878 128060 62805330
Bradycardia 143.74 10.07 263 555369 72964 62860426
Agitation 139.69 10.07 191 555441 59566 62873824
Drug hypersensitivity 139.35 10.07 1898 553734 308789 62624601
Respiratory arrest 138.49 10.07 56 555576 32589 62900801
Lactic acidosis 136.30 10.07 83 555549 38204 62895186
Hyperhidrosis 135.40 10.07 486 555146 107350 62826040
Somnolence 134.24 10.07 963 554669 177722 62755668
Diarrhoea 130.47 10.07 5033 550599 710333 62223057
Sleep disorder due to general medical condition, insomnia type 129.08 10.07 841 554791 51376 62882014
Hypotension 128.18 10.07 1649 553983 270955 62662435
Anxiety 125.38 10.07 1257 554375 216284 62717106
Small for dates baby 124.69 10.07 159 555473 3592 62929798
Rash 119.44 10.07 6025 549607 554846 62378544
Renal failure 117.52 10.07 579 555053 117073 62816317
Rhabdomyolysis 116.97 10.07 127 555505 43824 62889566
Tremor 115.92 10.07 680 554952 131559 62801831
Irritable bowel syndrome 115.52 10.07 1166 554466 81246 62852144
Fatigue 115.17 10.07 9137 546495 878891 62054499
Neoplasm progression 115.02 10.07 90 555542 36338 62897052
C-reactive protein abnormal 114.90 10.07 744 554888 45352 62888038
Cardiac failure 114.41 10.07 398 555234 88744 62844646
Pregnancy 111.23 10.07 625 555007 36211 62897179
Hyponatraemia 111.01 10.07 552 555080 111348 62822042
Cardio-respiratory arrest 110.99 10.07 223 555409 59736 62873654
Intentional self-injury 109.07 10.07 44 555588 25643 62907747
Tachycardia 106.55 10.07 602 555030 117554 62815836
Abortion spontaneous 106.40 10.07 743 554889 46452 62886938
Dyspnoea 104.74 10.07 4727 550905 656586 62276804
Osteoarthritis 102.72 10.07 1281 554351 94062 62839328
Lower respiratory tract infection 102.67 10.07 1678 553954 130629 62802761
Drug reaction with eosinophilia and systemic symptoms 102.60 10.07 87 555545 33749 62899641
Asthenia 102.39 10.07 2565 553067 381039 62552351
Blood cholesterol increased 99.86 10.07 1260 554372 92772 62840618
Condition aggravated 94.80 10.07 4365 551267 397852 62535538
Arthritis 94.37 10.07 1482 554150 114439 62818951
Serotonin syndrome 94.24 10.07 68 555564 28614 62904776
Liver injury 93.51 10.07 874 554758 59646 62873744
Live birth 93.30 10.07 458 555174 25172 62908218
No adverse event 93.13 10.07 136 555496 41269 62892121
Vomiting 91.82 10.07 3984 551648 555633 62377757
Syncope 90.87 10.07 627 555005 116758 62816632
Psoriasis 90.12 10.07 1160 554472 85797 62847593
Coma 89.76 10.07 277 555355 64087 62869303
Intentional product misuse 88.67 10.07 257 555375 60660 62872730
Sedation complication 88.59 10.07 9 555623 13813 62919577
Neuropathy peripheral 88.55 10.07 606 555026 113061 62820329
Drug resistance 88.44 10.07 45 555587 22888 62910502
Sopor 87.73 10.07 42 555590 22122 62911268
Hepatic failure 87.39 10.07 110 555522 35546 62897844
Drug dependence 87.25 10.07 53 555579 24430 62908960
Dizziness 86.61 10.07 2987 552645 426938 62506452
Type 2 diabetes mellitus 86.33 10.07 897 554735 62971 62870419
Myalgia 85.49 10.07 844 554788 145685 62787705
Macular degeneration 85.16 10.07 54 555578 24322 62909068
Hypoglycaemia 84.11 10.07 258 555374 59807 62873583
Renal impairment 83.03 10.07 444 555188 87911 62845479
Multiple sclerosis relapse 82.49 10.07 189 555443 48289 62885101
Cognitive disorder 82.32 10.07 234 555398 55581 62877809
Fibromyalgia 80.49 10.07 1066 554566 79354 62854036
Drug ineffective for unapproved indication 78.47 10.07 110 555522 33953 62899437
Drug withdrawal syndrome 77.57 10.07 74 555558 27120 62906270
Balance disorder 76.71 10.07 429 555203 83993 62849397
Angioedema 75.31 10.07 195 555437 47770 62885620
Intentional product use issue 75.07 10.07 1553 554079 126339 62807051
Joint effusion 74.81 10.07 322 555310 16738 62916652
Orthostatic hypotension 74.46 10.07 126 555506 36034 62897356
Device expulsion 74.41 10.07 119 555513 34803 62898587
Blood glucose increased 74.27 10.07 429 555203 83327 62850063
Creatinine renal clearance decreased 74.18 10.07 25 555607 16283 62917107
Metabolic acidosis 73.26 10.07 180 555452 44889 62888501
Hyperglycaemia 73.05 10.07 161 555471 41706 62891684
Respiratory failure 72.59 10.07 557 555075 101301 62832089
Cardiac failure congestive 71.89 10.07 493 555139 91940 62841450
Basal cell carcinoma 71.11 10.07 454 555178 27537 62905853
Hypoxia 70.77 10.07 276 555356 59516 62873874
Product quality issue 70.20 10.07 129 555503 35736 62897654
Metastases to bone 70.15 10.07 49 555583 20970 62912420
Palmar-plantar erythrodysaesthesia syndrome 69.99 10.07 59 555573 22956 62910434
Thrombocytopenia 69.98 10.07 917 554715 150240 62783150
Peripheral swelling 69.38 10.07 2917 552715 263025 62670365
Blood pressure diastolic abnormal 68.86 10.07 281 555351 14261 62919129
Hallucination 68.82 10.07 247 555385 54570 62878820
Ill-defined disorder 68.73 10.07 1051 554581 80704 62852686
COVID-19 68.70 10.07 645 554987 112458 62820932
Multiple organ dysfunction syndrome 67.79 10.07 261 555371 56491 62876899
Neutrophil count decreased 67.64 10.07 259 555373 56147 62877243
Contusion 67.35 10.07 1755 553877 148289 62785101
Insomnia 67.28 10.07 1404 554228 213848 62719542
Blood pressure systolic abnormal 66.86 10.07 263 555369 13123 62920267
Vision blurred 66.77 10.07 500 555132 91424 62841966
Myocardial infarction 66.69 10.07 556 555076 99337 62834053
Seizure 66.51 10.07 791 554841 131843 62801547
Feeling abnormal 66.24 10.07 907 554725 147485 62785905
Asthma 65.41 10.07 757 554875 126804 62806586
Blood pressure fluctuation 65.21 10.07 656 554976 45661 62887729
Disability assessment scale score increased 64.96 10.07 108 555524 3125 62930265
Red blood cell sedimentation rate increased 64.88 10.07 629 555003 43353 62890037
Congenital umbilical hernia 64.68 10.07 38 555594 275 62933115
Anaphylactic reaction 64.43 10.07 328 555304 65772 62867618
Foot deformity 64.25 10.07 441 555191 27412 62905978
Caesarean section 63.89 10.07 307 555325 16725 62916665
Chest discomfort 63.88 10.07 634 554998 109335 62824055
Hepatic function abnormal 62.23 10.07 146 555486 36996 62896394
Cytomegalovirus infection 62.15 10.07 55 555577 20897 62912493
Atrial septal defect 60.68 10.07 165 555467 6773 62926617
Ventricular septal defect 59.95 10.07 124 555508 4254 62929136
Diabetic ketoacidosis 58.25 10.07 56 555576 20449 62912941
Anaemia 58.23 10.07 2042 553590 291388 62642002
Respiratory depression 57.41 10.07 24 555608 13691 62919699
White blood cell count decreased 56.90 10.07 865 554767 138239 62795151
Juvenile idiopathic arthritis 56.28 10.07 103 555529 3223 62930167
Stomatitis 55.85 10.07 1600 554032 137125 62796265
Suicidal ideation 55.19 10.07 320 555312 62101 62871289
Mydriasis 54.96 10.07 18 555614 11938 62921452
Product use in unapproved indication 54.50 10.07 1173 554459 177907 62755483
C-reactive protein increased 54.24 10.07 1146 554486 93561 62839829
Poisoning 54.16 10.07 26 555606 13674 62919716
Cytokine release syndrome 53.85 10.07 29 555603 14285 62919105
Drug level increased 53.80 10.07 72 555560 22664 62910726
Ejection fraction decreased 53.58 10.07 70 555562 22262 62911128
Blood creatine phosphokinase increased 53.10 10.07 117 555515 30313 62903077
Altered state of consciousness 52.79 10.07 87 555545 25143 62908247
Dehydration 52.61 10.07 1136 554496 172218 62761172
Anaphylactic shock 51.81 10.07 79 555553 23554 62909836
Joint laxity 51.79 10.07 84 555548 2380 62931010
Osteoporosis 51.66 10.07 746 554886 56592 62876798
Sinusitis 51.60 10.07 2452 553180 224201 62709189
Pulmonary fibrosis 51.40 10.07 554 555078 39255 62894135
Wrong technique in product usage process 51.23 10.07 327 555305 62013 62871377
Grip strength decreased 50.89 10.07 352 555280 21935 62911455
Ventricular tachycardia 50.69 10.07 60 555572 19919 62913471
Mental status changes 50.66 10.07 177 555455 39422 62893968
Dysmorphism 50.63 10.07 80 555552 2216 62931174
Inflammation 50.56 10.07 1006 554626 81267 62852123
Polyarthritis 50.40 10.07 199 555433 9947 62923443
Depression 50.13 10.07 1322 554310 195170 62738220
Neurotoxicity 49.92 10.07 45 555587 16945 62916445
Acute hepatic failure 49.83 10.07 52 555580 18275 62915115
Bone erosion 49.82 10.07 295 555337 17422 62915968
Urticaria 49.59 10.07 1089 554543 164713 62768677
Loss of consciousness 49.52 10.07 731 554901 117390 62816000
Blood pressure decreased 49.47 10.07 349 555283 64673 62868717
Blood pressure systolic increased 49.40 10.07 633 554999 46764 62886626
Joint destruction 49.10 10.07 143 555489 6109 62927281
Shock 49.01 10.07 81 555551 23382 62910008
Palpitations 48.98 10.07 693 554939 112077 62821313
Torsade de pointes 48.85 10.07 28 555604 13323 62920067
Muscle spasticity 48.60 10.07 72 555560 21722 62911668
Abnormal behaviour 48.55 10.07 70 555562 21356 62912034
Injection site erythema 48.13 10.07 1008 554624 82166 62851224
Metastases to liver 48.09 10.07 83 555549 23556 62909834
Platelet count decreased 47.51 10.07 722 554910 115400 62817990
Joint range of motion decreased 47.45 10.07 463 555169 31965 62901425
Premature labour 47.35 10.07 226 555406 12278 62921112
Encephalopathy 47.17 10.07 176 555456 38444 62894946
Fluid retention 47.07 10.07 317 555315 59369 62874021
Emotional distress 46.86 10.07 138 555494 32411 62900979
Dysphagia 46.85 10.07 522 555110 88063 62845327
Blood calcium decreased 46.73 10.07 101 555531 26350 62907040
Unresponsive to stimuli 45.41 10.07 148 555484 33668 62899722
Akathisia 45.28 10.07 12 555620 9134 62924256
Restlessness 45.27 10.07 121 555511 29332 62904058
Device difficult to use 45.18 10.07 28 555604 12768 62920622
Flushing 44.39 10.07 431 555201 74656 62858734
Weight increased 44.20 10.07 2745 552887 258047 62675343
Speech disorder 44.06 10.07 194 555438 40435 62892955
Hospitalisation 43.57 10.07 505 555127 84576 62848814
Tuberculosis 43.45 10.07 204 555428 11007 62922383
Accidental exposure to product 43.34 10.07 111 555521 27294 62906096
Myelosuppression 43.14 10.07 89 555543 23614 62909776
Neuroleptic malignant syndrome 43.10 10.07 26 555606 12030 62921360
Extrapyramidal disorder 42.98 10.07 32 555600 13252 62920138
Drug ineffective 42.95 10.07 10036 545596 1034729 61898661
Dysarthria 42.73 10.07 210 555422 42501 62890889
Infection 42.58 10.07 2432 553200 226741 62706649
Schizophrenia 42.33 10.07 17 555615 9935 62923455
Drug tolerance decreased 42.30 10.07 280 555352 17193 62916197
General physical health deterioration 41.71 10.07 2159 553473 199243 62734147
Disturbance in attention 41.62 10.07 182 555450 38007 62895383
Respiratory disorder 41.54 10.07 188 555444 38894 62894496
Neck deformity 41.48 10.07 70 555562 2051 62931339
Ascites 41.47 10.07 199 555433 40529 62892861
Pre-eclampsia 41.30 10.07 174 555458 8959 62924431
Pain in jaw 41.17 10.07 218 555414 43278 62890112
Osteonecrosis of jaw 41.00 10.07 163 555469 34960 62898430
Injection site pruritus 40.25 10.07 586 555046 44530 62888860
Withdrawal syndrome 39.96 10.07 71 555561 19926 62913464
Hypokalaemia 39.91 10.07 653 554979 103151 62830239
Loss of personal independence in daily activities 39.66 10.07 1124 554508 96166 62837224
Blood alkaline phosphatase increased 39.21 10.07 218 555414 42749 62890641
Cerebrovascular accident 39.12 10.07 687 554945 107337 62826053
Posterior reversible encephalopathy syndrome 38.97 10.07 57 555575 17288 62916102
Dystonia 38.95 10.07 38 555594 13781 62919609
Hepatotoxicity 38.88 10.07 179 555453 36862 62896528
Depressed mood 38.84 10.07 200 555432 39991 62893399
Sepsis 38.84 10.07 1031 554601 152092 62781298
Disease recurrence 38.81 10.07 121 555511 27909 62905481
Injection site reaction 38.81 10.07 724 554908 57800 62875590
Psychotic disorder 38.49 10.07 107 555525 25605 62907785
Gamma-glutamyltransferase increased 38.43 10.07 160 555472 33871 62899519
Hypomania 38.38 10.07 5 555627 6325 62927065
Disorientation 38.31 10.07 196 555436 39256 62894134
Haematotoxicity 38.30 10.07 17 555615 9359 62924031
Product dose omission issue 38.08 10.07 1669 553963 232644 62700746
Chronic kidney disease 37.88 10.07 237 555395 45161 62888229
Maternal exposure before pregnancy 37.66 10.07 149 555483 7454 62925936
Exposure to toxic agent 37.52 10.07 3 555629 5584 62927806
Blood creatinine increased 37.38 10.07 542 555090 87302 62846088
Disseminated intravascular coagulation 36.86 10.07 69 555563 18982 62914408
Leukopenia 36.81 10.07 466 555166 76824 62856566
Decreased appetite 36.63 10.07 1809 553823 249243 62684147
Haemorrhage 36.61 10.07 349 555283 60673 62872717
Dyskinesia 36.42 10.07 150 555482 31852 62901538
Hypothermia 36.40 10.07 39 555593 13542 62919848
Blood bilirubin increased 36.36 10.07 184 555448 36956 62896434
Disability 36.28 10.07 280 555352 18067 62915323
Premature rupture of membranes 36.18 10.07 111 555521 4882 62928508
Blood pressure diastolic decreased 36.11 10.07 330 555302 22376 62911014
Hyperkalaemia 36.02 10.07 302 555330 53901 62879489
Metastases to central nervous system 35.84 10.07 37 555595 13068 62920322
Multiple fractures 35.76 10.07 160 555472 8458 62924932
Maternal drugs affecting foetus 35.65 10.07 114 555518 5128 62928262
Ventricular fibrillation 35.38 10.07 31 555601 11836 62921554
Pancytopenia 35.21 10.07 1104 554528 95829 62837561
Bone pain 35.17 10.07 307 555325 54334 62879056
Rheumatoid nodule 35.15 10.07 264 555368 16891 62916499
Mania 34.87 10.07 34 555598 12333 62921057
Polyneuropathy 34.72 10.07 46 555586 14543 62918847
Brain oedema 34.57 10.07 44 555588 14151 62919239
Inappropriate antidiuretic hormone secretion 34.56 10.07 51 555581 15411 62917979
Dysgeusia 34.42 10.07 253 555379 46457 62886933
Respiratory disorder neonatal 34.07 10.07 48 555584 1197 62932193
Parkinsonism 33.96 10.07 25 555607 10414 62922976
Back pain 33.72 10.07 1929 553703 262216 62671174
Arrhythmia 33.46 10.07 196 555436 37944 62895446
Obstructive airways disorder 33.38 10.07 83 555549 20616 62912774
Developmental hip dysplasia 33.33 10.07 50 555582 1322 62932068
Second primary malignancy 33.15 10.07 14 555618 7939 62925451
Post transplant lymphoproliferative disorder 32.97 10.07 3 555629 5028 62928362
Respiratory distress 32.78 10.07 169 555463 33782 62899608
Forced expiratory volume decreased 32.46 10.07 3 555629 4965 62928425
Pulmonary embolism 32.45 10.07 775 554857 115909 62817481
Joint stiffness 32.44 10.07 531 555101 41338 62892052
Pulmonary oedema 32.42 10.07 315 555317 54558 62878832
Transplant rejection 32.33 10.07 28 555604 10752 62922638
Bronchospasm 32.20 10.07 64 555568 17216 62916174
Irritability 32.19 10.07 155 555477 31539 62901851
Latent tuberculosis 32.05 10.07 71 555561 2556 62930834
Hyperlipidaemia 31.93 10.07 78 555554 19493 62913897
Panic attack 31.91 10.07 95 555537 22236 62911154
Device use error 31.65 10.07 6 555626 5755 62927635
Substance abuse 31.15 10.07 3 555629 4804 62928586
Large for dates baby 31.08 10.07 29 555603 454 62932936
Chronic sinusitis 31.08 10.07 40 555592 12803 62920587
Procedural pain 30.65 10.07 92 555540 21477 62911913
Colitis 30.64 10.07 274 555358 48254 62885136
Thrombotic microangiopathy 29.82 10.07 29 555603 10532 62922858
Premature delivery 29.71 10.07 400 555232 29881 62903509
Nodule 29.69 10.07 298 555334 20728 62912662
Dyspnoea exertional 29.68 10.07 361 555271 59941 62873449
Vertigo 29.68 10.07 358 555274 59529 62873861
Off label use 29.54 10.07 5325 550307 669137 62264253
Hypomagnesaemia 29.50 10.07 140 555492 28597 62904793
Alanine aminotransferase increased 29.47 10.07 687 554945 103083 62830307
Muscle twitching 29.33 10.07 82 555550 19586 62913804
Atrioventricular block complete 29.21 10.07 18 555614 8233 62925157
Foetal anticonvulsant syndrome 29.08 10.07 31 555601 574 62932816
Tenderness 29.04 10.07 314 555318 22264 62911126
Stress cardiomyopathy 29.01 10.07 24 555608 9426 62923964
Coagulopathy 28.93 10.07 88 555544 20456 62912934
Status epilepticus 28.75 10.07 56 555576 15177 62918213
Malignant melanoma 28.73 10.07 184 555448 11172 62922218
Cholestasis 28.71 10.07 146 555486 29288 62904102
Tumour lysis syndrome 28.65 10.07 22 555610 8968 62924422
Hemiparesis 28.50 10.07 106 555526 23176 62910214
Lymphocyte count decreased 28.44 10.07 152 555480 30105 62903285
Aspartate aminotransferase increased 28.42 10.07 588 555044 89689 62843701
Prescribed underdose 28.23 10.07 390 555242 29299 62904091
Laryngitis 28.22 10.07 249 555383 16718 62916672
Sinus tachycardia 28.09 10.07 113 555519 24155 62909235
Cardiogenic shock 28.07 10.07 73 555559 17859 62915531
Product administration error 28.05 10.07 101 555531 22296 62911094
Graft versus host disease 28.04 10.07 12 555620 6751 62926639
Musculoskeletal pain 27.95 10.07 1029 554603 91248 62842142
Gastrointestinal haemorrhage 27.89 10.07 521 555111 80655 62852735
Proteinuria 27.68 10.07 81 555551 19064 62914326
Lethargy 27.68 10.07 335 555297 55672 62877718
Adverse event 27.66 10.07 781 554851 66778 62866612
Acute chest syndrome 27.60 10.07 35 555597 786 62932604
Face oedema 27.46 10.07 88 555544 20124 62913266
Joint dislocation 27.30 10.07 268 555364 18532 62914858
Muscle spasms 27.29 10.07 1103 554529 155047 62778343
Headache 27.25 10.07 5004 550628 628237 62305153
Nightmare 27.18 10.07 82 555550 19112 62914278
Atrial fibrillation 27.09 10.07 795 554837 115841 62817549
Dry skin 27.08 10.07 343 555289 56544 62876846
Injection site swelling 27.02 10.07 575 555057 46997 62886393
Cerebral haemorrhage 26.91 10.07 158 555474 30571 62902819
Lupus-like syndrome 26.76 10.07 227 555405 15068 62918322
Venoocclusive liver disease 26.64 10.07 5 555627 4830 62928560
Enthesopathy 26.56 10.07 147 555485 8467 62924923
Haemorrhage intracranial 26.50 10.07 48 555584 13371 62920019
Talipes 26.45 10.07 48 555584 1492 62931898
Device related infection 26.40 10.07 110 555522 23282 62910108
Gastrointestinal disorder 26.37 10.07 1403 554229 129836 62803554
Skin ulcer 26.32 10.07 526 555106 42519 62890871
Limb deformity 26.28 10.07 86 555546 3916 62929474
Nasal polyps 26.20 10.07 10 555622 6029 62927361
Memory impairment 26.16 10.07 703 554929 103555 62829835
Pulmonary tuberculosis 26.10 10.07 93 555539 4424 62928966
Miosis 26.09 10.07 16 555616 7337 62926053
Malaise 26.03 10.07 3215 552417 412739 62520651
Acute graft versus host disease 25.67 10.07 4 555628 4424 62928966
Muscle rigidity 25.64 10.07 38 555594 11462 62921928
Localised infection 25.62 10.07 389 555243 29821 62903569
Asphyxia 25.57 10.07 11 555621 6170 62927220
Ankylosing spondylitis 25.45 10.07 168 555464 10306 62923084
Infusion site pain 25.40 10.07 70 555562 16799 62916591
Heart rate decreased 25.33 10.07 549 555083 45011 62888379
Wheelchair user 25.24 10.07 116 555516 6203 62927187
Bradyphrenia 25.03 10.07 15 555617 6965 62926425
Aggression 24.99 10.07 113 555519 23385 62910005
Pulmonary arterial hypertension 24.97 10.07 107 555525 22470 62910920
Sleep apnoea syndrome 24.87 10.07 151 555481 28982 62904408
Chest pain 24.74 10.07 1593 554039 214366 62719024
Placental disorder 24.72 10.07 46 555586 1458 62931932
Personality disorder 24.59 10.07 10 555622 5801 62927589
Angina pectoris 24.59 10.07 158 555474 29920 62903470
Swollen tongue 24.45 10.07 191 555441 34609 62898781
Birth mark 24.43 10.07 17 555615 170 62933220
Acute generalised exanthematous pustulosis 24.43 10.07 37 555595 11062 62922328
Cytopenia 24.27 10.07 40 555592 11561 62921829
Erythema multiforme 24.27 10.07 32 555600 10137 62923253
Fear 24.06 10.07 65 555567 15701 62917689
Blood pressure diastolic increased 23.98 10.07 160 555472 9850 62923540
International normalised ratio increased 23.98 10.07 275 555357 46150 62887240
Metastases to lung 23.95 10.07 47 555585 12703 62920687
Synovial cyst 23.95 10.07 165 555467 10268 62923122
Pleural effusion 23.78 10.07 627 555005 92583 62840807
Stevens-Johnson syndrome 23.64 10.07 125 555507 24825 62908565
Skin exfoliation 23.58 10.07 252 555380 42850 62890540
Lip swelling 23.49 10.07 167 555465 30896 62902494
Malignant mediastinal neoplasm 23.49 10.07 44 555588 1402 62931988
Complication of device insertion 23.48 10.07 19 555613 7545 62925845
Multiple-drug resistance 23.39 10.07 8 555624 5162 62928228
Mental disorder 23.38 10.07 132 555500 25787 62907603
Tardive dyskinesia 23.25 10.07 24 555608 8478 62924912
Complication of device removal 23.18 10.07 8 555624 5134 62928256
Diabetes mellitus 23.16 10.07 346 555286 55464 62877926
Glycosylated haemoglobin increased 23.03 10.07 46 555586 12352 62921038
Sexual dysfunction 22.99 10.07 5 555627 4354 62929036
Dermatitis atopic 22.80 10.07 31 555601 9693 62923697
Aphasia 22.78 10.07 182 555450 32818 62900572
Nervousness 22.72 10.07 168 555464 30811 62902579
Mobility decreased 22.71 10.07 1287 554345 119872 62813518
Peripheral venous disease 22.65 10.07 221 555411 15256 62918134
Pathogen resistance 22.59 10.07 14 555618 6384 62927006
Femur fracture 22.53 10.07 501 555131 41255 62892135
Accidental overdose 22.52 10.07 116 555516 23193 62910197
Pyrexia 22.51 10.07 3696 551936 466782 62466608
Neck mass 22.39 10.07 76 555556 3527 62929863
Facet joint syndrome 22.23 10.07 182 555450 11956 62921434
Tenosynovitis 22.20 10.07 201 555431 13594 62919796
Aspergillus infection 21.96 10.07 23 555609 8070 62925320
Skin papilloma 21.95 10.07 94 555538 4875 62928515
Cerebral infarction 21.92 10.07 121 555511 23772 62909618
Bronchopulmonary aspergillosis 21.83 10.07 26 555606 8609 62924781
Tenosynovitis stenosans 21.83 10.07 72 555560 3292 62930098
Smear cervix abnormal 21.82 10.07 66 555566 2880 62930510
Infective pulmonary exacerbation of cystic fibrosis 21.81 10.07 27 555605 8790 62924600
Cardiotoxicity 21.77 10.07 25 555607 8413 62924977
Coronary artery disease 21.69 10.07 180 555452 32197 62901193
Tachypnoea 21.68 10.07 78 555554 17224 62916166
Acute respiratory failure 21.64 10.07 195 555437 34290 62899100
Wound infection 21.49 10.07 284 555348 21126 62912264
Paraesthesia oral 21.45 10.07 91 555541 19165 62914225
Abortion late 21.42 10.07 14 555618 125 62933265
Rhinitis allergic 21.37 10.07 44 555588 11683 62921707
Speech disorder developmental 21.31 10.07 28 555604 652 62932738
Myocarditis 21.23 10.07 36 555596 10289 62923101
Schizoaffective disorder 21.15 10.07 3 555629 3559 62929831
Diabetes mellitus inadequate control 21.15 10.07 65 555567 15061 62918329
Hallucination, auditory 21.01 10.07 51 555581 12773 62920617
Polyhydramnios 20.86 10.07 55 555577 2216 62931174
Genital haemorrhage 20.85 10.07 20 555612 7312 62926078
Red blood cell sedimentation rate 20.81 10.07 91 555541 4763 62928627
Jaundice 20.81 10.07 160 555472 29091 62904299
Exomphalos 20.75 10.07 25 555607 532 62932858
Retinitis 20.64 10.07 108 555524 6088 62927302
Acidosis 20.59 10.07 42 555590 11191 62922199
Breast cancer stage I 20.53 10.07 18 555614 6871 62926519
Anuria 20.49 10.07 50 555582 12501 62920889
Pseudomonas infection 20.49 10.07 42 555590 11171 62922219
Crying 20.45 10.07 120 555512 23223 62910167
Obesity 20.36 10.07 372 555260 29580 62903810
Pulmonary hypertension 20.32 10.07 217 555415 36906 62896484
Foetal death 20.30 10.07 165 555467 10815 62922575
Acute graft versus host disease in skin 20.28 10.07 3 555629 3449 62929941
Arthritis infective 20.27 10.07 111 555521 6367 62927023
Toxic epidermal necrolysis 20.25 10.07 134 555498 25200 62908190
Dislocation of vertebra 20.08 10.07 137 555495 8498 62924892
Clostridium difficile colitis 20.08 10.07 102 555530 20467 62912923
Pancreatitis 20.06 10.07 305 555327 48750 62884640
Muscular weakness 19.96 10.07 871 554761 121482 62811908
Rotator cuff repair 19.93 10.07 52 555580 2082 62931308
Paralysis 19.92 10.07 35 555597 9865 62923525
Infantile vomiting 19.90 10.07 13 555619 116 62933274
Agitation neonatal 19.83 10.07 24 555608 513 62932877
Lip dry 19.83 10.07 215 555417 15255 62918135
Melaena 19.81 10.07 170 555462 30195 62903195
Cardiac failure acute 19.77 10.07 33 555599 9490 62923900
Toxic skin eruption 19.75 10.07 53 555579 12832 62920558
Learning disorder 19.63 10.07 27 555605 658 62932732
Rash erythematous 19.61 10.07 258 555374 42252 62891138
Vascular device infection 19.60 10.07 21 555611 7291 62926099
Hyperprolactinaemia 19.53 10.07 5 555627 3895 62929495
Synovial fluid analysis 19.45 10.07 56 555576 2377 62931013
Ketoacidosis 19.42 10.07 7 555625 4371 62929019
Therapy partial responder 19.41 10.07 40 555592 10618 62922772
Stillbirth 19.37 10.07 113 555519 6637 62926753
Anhedonia 19.31 10.07 42 555590 10932 62922458
Anti-cyclic citrullinated peptide antibody 19.31 10.07 113 555519 6645 62926745
Maternal exposure timing unspecified 19.28 10.07 117 555515 6970 62926420
Blood glucose decreased 19.28 10.07 106 555526 20846 62912544
Cough 19.26 10.07 2255 553377 290488 62642902
Patent ductus arteriosus 19.24 10.07 81 555551 4169 62929221
Renal disorder 19.18 10.07 190 555442 32784 62900606
Body height below normal 19.17 10.07 52 555580 2131 62931259
Haemoptysis 19.11 10.07 160 555472 28566 62904824
Complication associated with device 19.06 10.07 80 555552 16898 62916492
Pulmonary congestion 18.98 10.07 83 555549 17335 62916055
Haematoma 18.87 10.07 204 555428 34616 62898774
Bradypnoea 18.87 10.07 4 555628 3546 62929844
Therapeutic response decreased 18.85 10.07 687 554945 60838 62872552
Abdominal distension 18.72 10.07 596 555036 86019 62847371
Injection site bruising 18.72 10.07 490 555142 41420 62891970
Graft versus host disease in gastrointestinal tract 18.63 10.07 3 555629 3238 62930152
Product adhesion issue 18.59 10.07 9 555623 4710 62928680
Tinnitus 18.41 10.07 211 555421 35417 62897973
Pericardial effusion 18.41 10.07 171 555461 29887 62903503
Affective disorder 18.39 10.07 16 555616 6130 62927260
Atrioventricular block 18.31 10.07 24 555608 7623 62925767
Feeling hot 18.29 10.07 320 555312 50034 62883356
Loose body in joint 18.29 10.07 37 555595 1249 62932141
Hypophosphataemia 18.28 10.07 46 555586 11380 62922010
Anaemia macrocytic 18.18 10.07 69 555563 3385 62930005
Cleft lip and palate 18.15 10.07 25 555607 610 62932780
Gastroenteritis viral 18.14 10.07 300 555332 23400 62909990
Transplant dysfunction 18.14 10.07 10 555622 4862 62928528
Illness 18.07 10.07 311 555321 48748 62884642
Sinus bradycardia 17.97 10.07 66 555566 14485 62918905
Clear cell renal cell carcinoma 17.97 10.07 40 555592 1445 62931945
Paranoia 17.93 10.07 48 555584 11631 62921759
Colitis microscopic 17.91 10.07 34 555598 9305 62924085
Prescribed overdose 17.87 10.07 408 555224 33745 62899645
Body temperature decreased 17.76 10.07 263 555369 20056 62913334
Chills 17.69 10.07 811 554821 112567 62820823
Injection site pain 17.69 10.07 1342 554290 128458 62804932
Cyanosis 17.68 10.07 82 555550 16853 62916537
Sensitisation 17.62 10.07 4 555628 3382 62930008
Spinal stenosis 17.58 10.07 204 555428 14721 62918669
Pain in extremity 17.55 10.07 3225 552407 328261 62605129
Febrile bone marrow aplasia 17.53 10.07 23 555609 7302 62926088
Breast feeding 17.52 10.07 29 555603 836 62932554
Injection site rash 17.45 10.07 246 555386 18563 62914827
Multiple allergies 17.44 10.07 62 555570 13740 62919650
Body temperature increased 17.42 10.07 225 555407 36967 62896423
Dysuria 17.36 10.07 200 555432 33538 62899852
Acute myeloid leukaemia 17.33 10.07 84 555548 17063 62916327
Sleep disorder due to a general medical condition 17.31 10.07 52 555580 12136 62921254
Synovial disorder 17.25 10.07 48 555584 1997 62931393
Rheumatoid lung 17.16 10.07 73 555559 3775 62929615
Adjustment disorder with depressed mood 17.10 10.07 150 555482 10054 62923336
Abortion threatened 17.08 10.07 23 555609 549 62932841
Breast cancer female 17.08 10.07 61 555571 13498 62919892
Labelled drug-drug interaction medication error 17.06 10.07 60 555572 13339 62920051
Haemorrhage in pregnancy 17.05 10.07 46 555586 1879 62931511
Blood potassium decreased 16.94 10.07 262 555370 41764 62891626
Antinuclear antibody positive 16.90 10.07 124 555508 7875 62925515
Product preparation error 16.89 10.07 17 555615 6075 62927315
Pancreatitis acute 16.88 10.07 154 555478 27012 62906378
Haemophagocytic lymphohistiocytosis 16.83 10.07 43 555589 10584 62922806
Renal injury 16.71 10.07 36 555596 9403 62923987
Treatment noncompliance 16.68 10.07 228 555404 37097 62896293
Urinary retention 16.63 10.07 177 555455 30124 62903266
Bronchioloalveolar carcinoma 16.62 10.07 10 555622 76 62933314
Paraesthesia 16.60 10.07 1166 554466 155800 62777590
Hypophagia 16.60 10.07 184 555448 31075 62902315
Hyperthyroidism 16.56 10.07 69 555563 14604 62918786
Tubulointerstitial nephritis 16.55 10.07 104 555528 19799 62913591
Delusion 16.55 10.07 52 555580 11965 62921425
Eating disorder 16.53 10.07 98 555534 18918 62914472
Jaundice cholestatic 16.52 10.07 24 555608 7300 62926090
Deep vein thrombosis postoperative 16.47 10.07 162 555470 11207 62922183
Polyuria 16.47 10.07 31 555601 8511 62924879
Hypothyroidism 16.44 10.07 268 555364 42364 62891026
Toxic encephalopathy 16.43 10.07 20 555612 6559 62926831
Human herpesvirus 6 infection 16.42 10.07 3 555629 2954 62930436
Hypervolaemia 16.41 10.07 164 555468 28249 62905141
Cholecystitis chronic 16.35 10.07 42 555590 10319 62923071
Neonatal respiratory distress syndrome 16.26 10.07 58 555574 2760 62930630
Peripheral sensory neuropathy 16.24 10.07 25 555607 7426 62925964
Mucosal inflammation 16.17 10.07 301 555331 46627 62886763
Hypernatraemia 16.14 10.07 26 555606 7583 62925807
Scleritis 16.02 10.07 79 555553 4349 62929041
Eosinophil count increased 15.97 10.07 46 555586 10882 62922508
Exostosis 15.93 10.07 232 555400 17630 62915760
Multiple drug therapy 15.88 10.07 6 555626 3640 62929750
Myoclonus 15.88 10.07 78 555554 15790 62917600
Incorrect product administration duration 15.87 10.07 50 555582 11496 62921894
Oliguria 15.87 10.07 35 555597 9066 62924324
Antibody test positive 15.87 10.07 56 555576 2651 62930739
Hepatic cytolysis 15.85 10.07 75 555557 15332 62918058
Rebound effect 15.85 10.07 10 555622 4516 62928874
Syndactyly 15.85 10.07 20 555612 447 62932943
Erythema 15.84 10.07 1323 554309 174428 62758962
Abdominal pain 15.83 10.07 2289 553343 291167 62642223
Congenital hydronephrosis 15.81 10.07 19 555613 403 62932987
Right ventricular failure 15.79 10.07 87 555545 17101 62916289
Skin cancer 15.79 10.07 162 555470 11333 62922057
B-cell lymphoma 15.75 10.07 64 555568 3241 62930149
Congenital arterial malformation 15.73 10.07 17 555615 320 62933070
Immune reconstitution inflammatory syndrome 15.72 10.07 18 555614 6066 62927324
Leukocytosis 15.69 10.07 148 555484 25787 62907603
Acute respiratory distress syndrome 15.69 10.07 131 555501 23403 62909987
Lymphopenia 15.64 10.07 95 555537 18232 62915158
Bone lesion 15.64 10.07 17 555615 5864 62927526
Serum ferritin increased 15.53 10.07 100 555532 6082 62927308
Induced labour 15.52 10.07 29 555603 922 62932468
Head injury 15.46 10.07 159 555473 27237 62906153
Pallor 15.42 10.07 182 555450 30386 62903004
Device dislocation 15.42 10.07 147 555485 25558 62907832
Fracture 15.40 10.07 249 555383 19335 62914055
Rash maculo-papular 15.30 10.07 192 555440 31704 62901686
Proctitis 15.29 10.07 15 555617 5426 62927964
Human antichimeric antibody positive 15.23 10.07 41 555591 1673 62931717
Systemic inflammatory response syndrome 15.22 10.07 16 555616 5605 62927785
Middle insomnia 15.19 10.07 58 555574 12585 62920805
Device breakage 15.16 10.07 51 555581 11491 62921899
Carotid artery thrombosis 15.16 10.07 3 555629 2791 62930599
Bursitis 15.10 10.07 428 555204 36613 62896777
Anger 15.05 10.07 57 555575 12399 62920991
Congenital cerebral cyst 15.04 10.07 15 555617 256 62933134
Hypoglycaemia neonatal 15.01 10.07 29 555603 946 62932444
Myopathy 15.01 10.07 49 555583 11142 62922248
Congenital hypertrichosis 14.99 10.07 4 555628 0 62933390
Fracture delayed union 14.98 10.07 51 555581 2371 62931019
Ileus 14.96 10.07 72 555560 14653 62918737
Laryngospasm 14.94 10.07 4 555628 3024 62930366
Klebsiella infection 14.89 10.07 33 555599 8533 62924857
Cushingoid 14.88 10.07 126 555506 8359 62925031
Product administered to patient of inappropriate age 14.88 10.07 5 555627 3263 62930127
Autism spectrum disorder 14.79 10.07 27 555605 843 62932547
Paradoxical drug reaction 14.78 10.07 9 555623 4143 62929247
Pulseless electrical activity 14.76 10.07 27 555605 7494 62925896
Heart rate increased 14.72 10.07 674 554958 93564 62839826
Normal newborn 14.70 10.07 124 555508 8217 62925173
Visual impairment 14.64 10.07 597 555035 83849 62849541
Deep vein thrombosis 14.62 10.07 592 555040 83208 62850182
Neurologic neglect syndrome 14.60 10.07 3 555629 2718 62930672
Eosinophilia 14.58 10.07 128 555504 22628 62910762
Cardiomyopathy 14.56 10.07 92 555540 17492 62915898
Respiration abnormal 14.50 10.07 21 555611 6396 62926994
Tumour marker increased 14.46 10.07 13 555619 4902 62928488
Mood altered 14.45 10.07 73 555559 14670 62918720
Colorectal cancer 14.28 10.07 7 555625 3638 62929752
Bradycardia neonatal 14.27 10.07 28 555604 924 62932466
Hypertelorism 14.25 10.07 19 555613 449 62932941
Dementia 14.23 10.07 101 555531 18693 62914697
Respiratory acidosis 14.19 10.07 23 555609 6692 62926698
Post-traumatic stress disorder 14.16 10.07 15 555617 5236 62928154
Abortion missed 14.16 10.07 40 555592 1679 62931711
Chronic obstructive pulmonary disease 14.12 10.07 429 555203 62257 62871133
Graft versus host disease in skin 14.03 10.07 4 555628 2901 62930489
Squamous cell carcinoma 14.00 10.07 126 555506 8506 62924884
Breast cancer metastatic 13.88 10.07 56 555576 11962 62921428
Lymphoedema 13.81 10.07 54 555578 11638 62921752
Nephropathy toxic 13.78 10.07 40 555592 9439 62923951
Adenovirus infection 13.78 10.07 7 555625 3564 62929826
Cholestasis of pregnancy 13.72 10.07 32 555600 1193 62932197
Chronic graft versus host disease 13.69 10.07 5 555627 3097 62930293
Product physical issue 13.69 10.07 14 555618 4966 62928424
Neutropenic colitis 13.64 10.07 5 555627 3090 62930300
Immunosuppression 13.46 10.07 127 555505 8687 62924703
Subdural haematoma 13.45 10.07 72 555560 14256 62919134
Blood lactic acid increased 13.41 10.07 26 555606 7060 62926330
Delirium 13.41 10.07 338 555294 50203 62883187
Circulatory collapse 13.35 10.07 125 555507 21813 62911577
Lupus vulgaris 13.29 10.07 94 555538 5900 62927490
Food allergy 13.25 10.07 53 555579 11348 62922042
Premature baby 13.22 10.07 255 555377 20480 62912910
Retrognathia 13.17 10.07 18 555614 436 62932954
Amylase increased 13.16 10.07 22 555610 6323 62927067
Mouth ulceration 13.14 10.07 380 555252 32604 62900786
Pregnancy with contraceptive device 13.12 10.07 13 555619 4681 62928709
Tendonitis 13.12 10.07 243 555389 19372 62914018
Naevus flammeus 13.08 10.07 10 555622 117 62933273
Hepatocellular injury 13.07 10.07 165 555467 27216 62906174
Acute myocardial infarction 13.04 10.07 200 555432 31924 62901466
Ear infection 13.03 10.07 432 555200 37781 62895609
Infusion site swelling 12.95 10.07 43 555589 9727 62923663
Salivary hypersecretion 12.95 10.07 30 555602 7636 62925754
Foetal distress syndrome 12.90 10.07 33 555599 1305 62932085
Amniotic fluid volume increased 12.90 10.07 11 555621 152 62933238
Fear of injection 12.89 10.07 107 555525 7057 62926333
Electrocardiogram QRS complex prolonged 12.87 10.07 20 555612 5918 62927472
Maternal exposure during breast feeding 12.83 10.07 72 555560 4169 62929221
Blood iron increased 12.82 10.07 36 555596 1506 62931884
Hypercholesterolaemia 12.81 10.07 260 555372 21074 62912316
Psychomotor hyperactivity 12.76 10.07 49 555583 10614 62922776
Hygroma colli 12.72 10.07 5 555627 12 62933378
Threatened labour 12.66 10.07 25 555607 829 62932561
Device issue 12.62 10.07 140 555492 23641 62909749
Gastroschisis 12.62 10.07 17 555615 406 62932984
Inadequate analgesia 12.56 10.07 5 555627 2938 62930452
Infusion site erythema 12.52 10.07 56 555576 11623 62921767
Blood parathyroid hormone decreased 12.52 10.07 136 555496 9655 62923735
Short stature 12.48 10.07 22 555610 668 62932722
Generalised oedema 12.47 10.07 84 555548 15734 62917656
Plasma cell myeloma 12.47 10.07 230 555402 35675 62897715
Acute coronary syndrome 12.46 10.07 46 555586 10080 62923310
Infusion site pruritus 12.45 10.07 21 555611 6014 62927376
Disturbance in social behaviour 12.43 10.07 10 555622 3983 62929407
Urinary incontinence 12.43 10.07 201 555431 31813 62901577
Ischaemic stroke 12.41 10.07 99 555533 17858 62915532
Cardiac disorder 12.39 10.07 344 555288 50472 62882918
Glomerular filtration rate decreased 12.37 10.07 68 555564 13373 62920017
Multiple sclerosis 12.34 10.07 145 555487 24227 62909163
Hepatitis B reactivation 12.33 10.07 6 555626 3131 62930259
Presyncope 12.32 10.07 170 555462 27615 62905775
Postoperative wound infection 12.28 10.07 148 555484 10777 62922613
Cytomegalovirus viraemia 12.27 10.07 19 555613 5630 62927760
Aspiration 12.26 10.07 51 555581 10800 62922590
Roseola 12.25 10.07 4 555628 4 62933386
Potentiating drug interaction 12.25 10.07 12 555620 4344 62929046
Anti-neutrophil cytoplasmic antibody positive vasculitis 12.25 10.07 5 555627 2894 62930496
Affect lability 12.24 10.07 53 555579 11098 62922292
Pulmonary haemorrhage 12.21 10.07 28 555604 7153 62926237
Fall 12.21 10.07 3149 552483 389185 62544205
Pruritus genital 12.19 10.07 4 555628 2650 62930740
Visual acuity reduced 12.18 10.07 127 555505 21699 62911691
Metastases to lymph nodes 12.17 10.07 34 555598 8124 62925266
Granuloma skin 12.11 10.07 120 555512 8317 62925073
Nasal obstruction 12.10 10.07 38 555594 1693 62931697
Product substitution issue 12.09 10.07 86 555546 15910 62917480
Crohn's disease 12.06 10.07 79 555553 4834 62928556
Personality change 12.01 10.07 27 555605 6946 62926444
Diabetes insipidus 11.98 10.07 4 555628 2621 62930769
Uterine perforation 11.96 10.07 27 555605 6936 62926454
Rectal haemorrhage 11.93 10.07 332 555300 48698 62884692
Ulcer 11.88 10.07 306 555326 25801 62907589
Injection site warmth 11.87 10.07 193 555439 15002 62918388
Throat tightness 11.86 10.07 150 555482 24737 62908653
Abdominal pain upper 11.86 10.07 1604 554028 204840 62728550
Catatonia 11.84 10.07 13 555619 4464 62928926
Pneumonia viral 11.83 10.07 33 555599 7889 62925501
Lymph gland infection 11.83 10.07 18 555614 482 62932908
Bacteraemia 11.82 10.07 96 555536 17252 62916138
Haemodynamic instability 11.80 10.07 41 555591 9149 62924241
Oedema peripheral 11.79 10.07 1465 554167 188046 62745344
Catheter site erythema 11.77 10.07 12 555620 4264 62929126
Hyperuricaemia 11.72 10.07 18 555614 5352 62928038
Bradykinesia 11.70 10.07 17 555615 5171 62928219
Hypocalcaemia 11.69 10.07 201 555431 31512 62901878
Hyperbilirubinaemia 11.68 10.07 55 555577 11259 62922131
Gestational hypertension 11.68 10.07 47 555585 2370 62931020
Lordosis 11.58 10.07 14 555618 299 62933091
Hot flush 11.55 10.07 350 555282 50809 62882581
Blood pressure inadequately controlled 11.54 10.07 16 555616 4962 62928428
Hepatitis acute 11.51 10.07 41 555591 9079 62924311
Fine motor skill dysfunction 11.49 10.07 77 555555 4748 62928642
Onychomycosis 11.48 10.07 113 555519 7819 62925571
Toxoplasma serology positive 11.48 10.07 5 555627 17 62933373
Acute pulmonary oedema 11.45 10.07 35 555597 8123 62925267
Drug screen positive 11.41 10.07 9 555623 3620 62929770
Twin pregnancy 11.38 10.07 29 555603 1144 62932246
Oligoarthritis 11.37 10.07 19 555613 552 62932838
Bronchial secretion retention 11.37 10.07 5 555627 2768 62930622
Placental insufficiency 11.36 10.07 33 555599 1408 62931982
Chondropathy 11.33 10.07 45 555587 2255 62931135
Terminal state 11.28 10.07 3 555629 2279 62931111
Dermatitis exfoliative 11.26 10.07 19 555613 5440 62927950
Congenital skin dimples 11.25 10.07 9 555623 113 62933277
Double ureter 11.24 10.07 3 555629 0 62933390
Congenital pulmonary artery anomaly 11.24 10.07 3 555629 0 62933390
Dactylitis 11.22 10.07 49 555583 2563 62930827
Catheter site pain 11.20 10.07 15 555617 4720 62928670
Progressive multifocal leukoencephalopathy 11.19 10.07 67 555565 12904 62920486
Product residue present 11.15 10.07 11 555621 3968 62929422
Foetal growth restriction 11.13 10.07 108 555524 7445 62925945
Injury 11.12 10.07 764 554868 72483 62860907
Anal prolapse 11.10 10.07 8 555624 85 62933305
Folate deficiency 11.07 10.07 47 555585 2428 62930962
Ankle arthroplasty 11.06 10.07 38 555594 1775 62931615
Hypoplastic right heart syndrome 11.04 10.07 7 555625 59 62933331
Haematocrit decreased 11.03 10.07 435 555197 38905 62894485
Drug effective for unapproved indication 11.02 10.07 8 555624 3356 62930034
Hypoplastic left heart syndrome 11.02 10.07 11 555621 188 62933202
Joint noise 11.01 10.07 71 555561 4321 62929069
Bone marrow failure 11.01 10.07 185 555447 29105 62904285
Polydipsia 11.01 10.07 9 555623 3555 62929835
Epistaxis 10.98 10.07 522 555110 72203 62861187
Epstein-Barr virus infection 10.97 10.07 35 555597 8015 62925375
Intracranial pressure increased 10.96 10.07 18 555614 5209 62928181
Corneal degeneration 10.94 10.07 8 555624 87 62933303
Sciatica 10.94 10.07 385 555247 33939 62899451
Hereditary angioedema 10.93 10.07 32 555600 7530 62925860
Drug abuser 10.88 10.07 6 555626 2917 62930473
Cleft palate 10.86 10.07 26 555606 986 62932404
Abortion incomplete 10.85 10.07 7 555625 3124 62930266
Impaired gastric emptying 10.80 10.07 50 555582 10282 62923108
Myocardial ischaemia 10.79 10.07 67 555565 12792 62920598
Small cell carcinoma 10.74 10.07 10 555622 156 62933234
Rales 10.74 10.07 66 555566 12631 62920759
Prothrombin consumption time prolonged 10.74 10.07 6 555626 39 62933351
Sleep terror 10.73 10.07 5 555627 2675 62930715
Eye pruritus 10.68 10.07 108 555524 18563 62914827
Dermatitis acneiform 10.66 10.07 17 555615 4979 62928411
Ingrown hair 10.66 10.07 19 555613 582 62932808
Implant site pain 10.65 10.07 4 555628 2436 62930954
Human anti-human antibody test 10.64 10.07 16 555616 424 62932966
Herpes zoster 10.64 10.07 849 554783 81613 62851777
Nail injury 10.64 10.07 20 555612 639 62932751
Panniculitis 10.60 10.07 149 555483 11236 62922154
Cyst rupture 10.60 10.07 20 555612 641 62932749
Reversible cerebral vasoconstriction syndrome 10.58 10.07 5 555627 2653 62930737
Vaginal discharge 10.54 10.07 43 555589 9155 62924235
Arnold-Chiari malformation 10.51 10.07 20 555612 645 62932745
Haematemesis 10.50 10.07 195 555437 30217 62903173
Sickle cell anaemia 10.48 10.07 18 555614 535 62932855
Atrial tachycardia 10.47 10.07 13 555619 4227 62929163
Lymphatic fistula 10.46 10.07 22 555610 764 62932626
Occult blood 10.45 10.07 30 555602 1271 62932119
Coordination abnormal 10.44 10.07 74 555558 13699 62919691
Joint lock 10.43 10.07 44 555588 2267 62931123
Ejection fraction 10.41 10.07 4 555628 2402 62930988
Teratoma benign 10.40 10.07 7 555625 66 62933324
Ataxia 10.39 10.07 84 555548 15111 62918279
Device use issue 10.38 10.07 5 555627 2625 62930765
Cervical incompetence 10.30 10.07 19 555613 598 62932792
Hypertransaminasaemia 10.27 10.07 27 555605 6582 62926808
Nasal oedema 10.26 10.07 33 555599 1489 62931901
Subarachnoid haemorrhage 10.22 10.07 78 555554 14205 62919185
Injection site haematoma 10.22 10.07 98 555534 6734 62926656
Skin plaque 10.10 10.07 38 555594 8282 62925108
Forceps delivery 10.10 10.07 11 555621 209 62933181
Wound infection pseudomonas 10.07 10.07 30 555602 1298 62932092
Congenital oesophageal anomaly 10.07 10.07 4 555628 10 62933380

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 681.09 10.28 968 202634 37133 34716196
Rheumatoid arthritis 518.86 10.28 855 202747 37383 34715946
Drug abuse 410.49 10.28 48 203554 99048 34654281
Toxicity to various agents 353.22 10.28 388 203214 199974 34553355
Completed suicide 314.09 10.28 91 203511 98077 34655252
Arthralgia 199.37 10.28 1680 201922 168361 34584968
Dysmorphism 193.90 10.28 155 203447 3001 34750328
Sickle cell anaemia with crisis 179.49 10.28 165 203437 3888 34749441
Psoriatic arthropathy 178.01 10.28 371 203231 19427 34733902
Atrial septal defect 173.89 10.28 215 203387 7177 34746152
Drug interaction 147.35 10.28 746 202856 225200 34528129
Hypospadias 147.00 10.28 133 203469 3068 34750261
Premature baby 143.88 10.28 339 203263 19294 34734035
Small for dates baby 131.14 10.28 137 203465 3790 34749539
Intentional overdose 123.14 10.28 50 203552 43624 34709705
Joint swelling 117.71 10.28 672 202930 59218 34694111
Psoriasis 113.76 10.28 488 203114 38324 34715005
Ventricular septal defect 109.98 10.28 126 203476 3875 34749454
Speech disorder developmental 106.15 10.28 94 203508 2106 34751223
Death 102.59 10.28 1667 201935 396382 34356947
Cryptorchism 98.07 10.28 87 203515 1954 34751375
Musculoskeletal stiffness 97.17 10.28 532 203070 46148 34707181
Maternal exposure during pregnancy 96.82 10.28 131 203471 4787 34748542
Product use in unapproved indication 93.36 10.28 360 203242 117139 34636190
Foetal anticonvulsant syndrome 92.09 10.28 67 203535 1120 34752209
Congenital umbilical hernia 86.48 10.28 40 203562 264 34753065
Neonatal respiratory distress syndrome 81.78 10.28 109 203493 3925 34749404
Enthesopathy 79.10 10.28 115 203487 4498 34748831
Pancytopenia 77.22 10.28 871 202731 94286 34659043
Respiratory disorder neonatal 75.39 10.28 68 203534 1562 34751767
Tenosynovitis 74.14 10.28 111 203491 4459 34748870
Suicide attempt 74.11 10.28 71 203531 39045 34714284
Autism spectrum disorder 72.94 10.28 78 203524 2218 34751111
Synovitis 72.49 10.28 213 203389 13853 34739476
Hypoglycaemia neonatal 72.02 10.28 71 203531 1830 34751499
Low birth weight baby 70.88 10.28 148 203454 7757 34745572
Exposure during pregnancy 70.66 10.28 159 203443 8775 34744554
Learning disorder 70.06 10.28 55 203547 1036 34752293
Blood pressure fluctuation 68.30 10.28 310 203292 24939 34728390
Coma 68.26 10.28 100 203502 45578 34707751
Hypotonia neonatal 67.97 10.28 59 203543 1286 34752043
Rhabdomyolysis 67.84 10.28 189 203413 67974 34685355
Overdose 66.65 10.28 288 203314 90771 34662558
Talipes 65.85 10.28 68 203534 1855 34751474
Febrile neutropenia 65.06 10.28 498 203104 136351 34616978
Drug dependence 64.64 10.28 30 203572 24187 34729142
Developmental delay 64.12 10.28 80 203522 2695 34750634
Maternal drugs affecting foetus 63.89 10.28 96 203506 3869 34749460
Agitation neonatal 63.46 10.28 52 203550 1044 34752285
Hepatic function abnormal 62.57 10.28 101 203501 44262 34709067
Syndactyly 62.37 10.28 47 203555 831 34752498
Disease progression 61.45 10.28 373 203229 107704 34645625
Arthropathy 60.30 10.28 313 203289 26594 34726735
C-reactive protein abnormal 60.15 10.28 147 203455 8563 34744766
Drug reaction with eosinophilia and systemic symptoms 60.15 10.28 62 203540 32950 34720379
Serotonin syndrome 59.21 10.28 21 203581 19912 34733417
Intentional product misuse 58.73 10.28 110 203492 45501 34707828
Foot deformity 58.20 10.28 99 203503 4438 34748891
Drug resistance 57.90 10.28 40 203562 25887 34727442
Off label use 53.95 10.28 1951 201651 417573 34335756
Pain 52.57 10.28 1562 202040 203113 34550216
Rheumatoid nodule 51.30 10.28 74 203528 2873 34750456
Nasopharyngitis 50.79 10.28 627 202975 69341 34683988
Language disorder 50.47 10.28 64 203538 2192 34751137
Renal aplasia 50.02 10.28 39 203563 727 34752602
Alanine aminotransferase abnormal 48.29 10.28 93 203509 4595 34748734
Blood pressure systolic increased 46.02 10.28 259 203343 22693 34730636
Joint laxity 45.67 10.28 29 203573 383 34752946
Intellectual disability 45.25 10.28 47 203555 1291 34752038
Arthritis 45.04 10.28 325 203277 31021 34722308
Dysgraphia 43.63 10.28 60 203542 2227 34751102
Multiple organ dysfunction syndrome 43.63 10.28 264 203338 76302 34677027
Nasal disorder 43.62 10.28 55 203547 1873 34751456
Maternal exposure during breast feeding 43.15 10.28 49 203553 1492 34751837
Drug withdrawal syndrome neonatal 42.56 10.28 76 203526 3543 34749786
Hypertonia neonatal 42.36 10.28 29 203573 438 34752891
Selective eating disorder 42.27 10.28 52 203550 1726 34751603
Cleft lip and palate 42.09 10.28 38 203564 874 34752455
Bradycardia 41.95 10.28 262 203340 75156 34678173
Exposure via breast milk 41.81 10.28 55 203547 1955 34751374
Altered state of consciousness 41.70 10.28 43 203559 22850 34730479
Poisoning 41.59 10.28 10 203592 12216 34741113
Hypertelorism 41.00 10.28 31 203571 551 34752778
Suicidal ideation 40.91 10.28 111 203491 40277 34713052
Foetal growth restriction 40.38 10.28 80 203522 4037 34749292
Palmar-plantar erythrodysaesthesia syndrome 40.11 10.28 24 203578 16771 34736558
Tongue disorder 39.99 10.28 93 203509 5246 34748083
Sedation 39.93 10.28 38 203564 20968 34732361
Ear disorder 39.49 10.28 49 203553 1641 34751688
C-reactive protein increased 39.34 10.28 485 203117 53613 34699716
Angioedema 39.16 10.28 101 203501 37273 34716056
Hyperbilirubinaemia neonatal 38.90 10.28 34 203568 748 34752581
Basal cell carcinoma 38.86 10.28 221 203381 19437 34733892
Joint effusion 38.40 10.28 90 203512 5103 34748226
Plagiocephaly 38.19 10.28 29 203573 519 34752810
Large for dates baby 38.00 10.28 36 203566 882 34752447
Blood pressure systolic abnormal 37.86 10.28 76 203526 3872 34749457
Renal failure 37.79 10.28 534 203068 130023 34623306
Acute kidney injury 37.60 10.28 1425 202177 303563 34449766
Osteoarthritis 37.53 10.28 227 203375 20415 34732914
Caesarean section 37.18 10.28 54 203548 2110 34751219
Immune reconstitution inflammatory syndrome 36.84 10.28 4 203598 8755 34744574
Somnolence 36.74 10.28 442 203160 110674 34642655
Bradycardia neonatal 36.13 10.28 36 203566 940 34752389
Psychotic disorder 36.07 10.28 54 203548 24398 34728931
Appendicolith 35.99 10.28 4 203598 8597 34744732
Cardiac arrest 35.95 10.28 372 203230 95787 34657542
Pathogen resistance 35.91 10.28 6 203596 9476 34743853
Respiratory arrest 35.77 10.28 68 203534 27975 34725354
Birth mark 35.20 10.28 18 203584 152 34753177
Motor developmental delay 35.17 10.28 30 203572 638 34752691
Peripheral swelling 35.17 10.28 634 202968 75907 34677422
Hand deformity 34.88 10.28 71 203531 3654 34749675
Neuroleptic malignant syndrome 34.61 10.28 32 203570 17902 34735427
Drug withdrawal syndrome 34.19 10.28 39 203563 19795 34733534
Delirium 34.12 10.28 136 203466 43855 34709474
Patent ductus arteriosus 33.89 10.28 66 203536 3288 34750041
Pulmonary fibrosis 33.25 10.28 202 203400 18194 34735135
Red blood cell sedimentation rate increased 33.09 10.28 123 203479 9039 34744290
Haemangioma congenital 33.02 10.28 26 203576 492 34752837
Blood pressure diastolic abnormal 32.93 10.28 81 203521 4737 34748592
Ear infection 32.59 10.28 132 203470 10099 34743230
Pain in extremity 32.28 10.28 965 202637 125548 34627781
Pectus excavatum 31.83 10.28 19 203583 223 34753106
Toxic epidermal necrolysis 31.74 10.28 48 203554 21598 34731731
Agitation 31.61 10.28 200 203402 57199 34696130
Grip strength decreased 31.59 10.28 62 203540 3107 34750222
Hypermobility syndrome 31.54 10.28 22 203580 343 34752986
Blood creatine phosphokinase increased 31.51 10.28 144 203458 44713 34708616
Sopor 30.92 10.28 16 203586 12120 34741209
Strabismus 30.92 10.28 44 203558 1687 34751642
Astigmatism 30.92 10.28 35 203567 1062 34752267
Congenital hydronephrosis 30.83 10.28 29 203573 704 34752625
Hydrops foetalis 30.31 10.28 31 203571 836 34752493
Congenital hand malformation 29.86 10.28 26 203576 569 34752760
Musculoskeletal pain 29.82 10.28 301 203301 31662 34721667
Acute chest syndrome 29.69 10.28 30 203572 797 34752532
Respiratory failure 29.69 10.28 449 203153 108123 34645206
Cytomegalovirus infection 29.44 10.28 68 203534 26067 34727262
Haemoglobin decreased 29.15 10.28 915 202687 119857 34633472
Spina bifida 29.02 10.28 21 203581 348 34752981
Low set ears 28.74 10.28 23 203579 446 34752883
Blood pressure diastolic decreased 28.70 10.28 117 203485 8977 34744352
Weight decreased 28.64 10.28 1278 202324 175023 34578306
Knee arthroplasty 28.63 10.28 102 203500 7342 34745987
Acute hepatic failure 28.50 10.28 24 203578 14050 34739279
Abnormal palmar/plantar creases 28.45 10.28 17 203585 200 34753129
Anal fistula 28.05 10.28 82 203520 5317 34748012
Dyspraxia 28.00 10.28 22 203580 415 34752914
Shock 27.98 10.28 62 203540 24117 34729212
Behaviour disorder 27.87 10.28 77 203525 4833 34748496
Tendonitis 27.59 10.28 116 203486 9024 34744305
Wrong technique in product usage process 27.43 10.28 112 203490 35874 34717455
Heart rate decreased 27.28 10.28 294 203308 31451 34721878
Otitis media 27.20 10.28 55 203547 2817 34750512
Kidney duplex 27.14 10.28 21 203581 387 34752942
Hyperglycaemia 26.99 10.28 128 203474 39352 34713977
Depressed level of consciousness 26.94 10.28 143 203459 42698 34710631
Wound 26.73 10.28 163 203439 14701 34738628
Jaundice neonatal 26.72 10.28 36 203566 1310 34752019
Hepatic failure 26.62 10.28 107 203495 34424 34718905
Malignant neoplasm progression 26.58 10.28 357 203245 87689 34665640
Polydactyly 26.49 10.28 34 203568 1179 34752150
Substance abuse 26.49 10.28 6 203596 7635 34745694
Finger deformity 26.35 10.28 38 203564 1475 34751854
Electrocardiogram QT prolonged 26.14 10.28 136 203466 40816 34712513
Hydrocele 26.06 10.28 45 203557 2042 34751287
Tuberculosis 26.01 10.28 109 203493 8468 34744861
Trisomy 18 25.93 10.28 27 203575 744 34752585
Bronchiolitis 25.65 10.28 57 203545 3119 34750210
Ventricular fibrillation 25.63 10.28 60 203542 22894 34730435
Psychomotor retardation 25.63 10.28 62 203540 3588 34749741
Infusion related reaction 25.62 10.28 443 203159 52614 34700715
Cardiogenic shock 25.59 10.28 75 203527 26543 34726786
Polyarthritis 25.57 10.28 71 203531 4469 34748860
Attention deficit hyperactivity disorder 25.43 10.28 50 203552 2509 34750820
Knee deformity 25.40 10.28 25 203577 643 34752686
Neurotoxicity 25.39 10.28 41 203561 17969 34735360
Congenital tricuspid valve incompetence 25.37 10.28 14 203588 140 34753189
Single umbilical artery 25.35 10.28 16 203586 209 34753120
Renal impairment 25.11 10.28 393 203209 94120 34659209
Drug ineffective for unapproved indication 24.91 10.28 64 203538 23651 34729678
Respiratory depression 24.82 10.28 35 203567 16210 34737119
Blood pressure increased 24.66 10.28 680 202922 87422 34665907
Congenital knee deformity 24.53 10.28 13 203589 119 34753210
Developmental coordination disorder 24.43 10.28 15 203587 186 34753143
General physical health deterioration 24.03 10.28 944 202658 127325 34626004
Diaphragmatic disorder 23.65 10.28 33 203569 1242 34752087
Drug intolerance 23.46 10.28 482 203120 59088 34694241
Ultrasound antenatal screen 23.39 10.28 22 203580 534 34752795
No adverse event 23.22 10.28 63 203539 22864 34730465
Educational problem 23.19 10.28 22 203580 540 34752789
Microcephaly 23.07 10.28 26 203576 785 34752544
Joint range of motion decreased 23.02 10.28 94 203508 7218 34746111
Colitis ulcerative 22.99 10.28 170 203432 16350 34736979
Drug ineffective 22.91 10.28 2321 201281 454430 34298899
Fine motor skill dysfunction 22.69 10.28 39 203563 1763 34751566
Venoocclusive liver disease 22.64 10.28 9 203593 7957 34745372
Vitamin D deficiency 22.45 10.28 87 203515 6521 34746808
Lower respiratory tract infection 22.29 10.28 282 203320 31355 34721974
Anal fissure 22.13 10.28 65 203537 4225 34749104
Hypoglycaemia 21.82 10.28 208 203394 54432 34698897
Cardiac failure 21.75 10.28 387 203215 90861 34662468
Weight decrease neonatal 21.58 10.28 17 203585 322 34753007
Inflammation 21.57 10.28 256 203346 28039 34725290
Cardio-respiratory arrest 21.40 10.28 212 203390 55061 34698268
Ectopic kidney 21.34 10.28 8 203594 28 34753301
Neonatal seizure 21.31 10.28 20 203582 484 34752845
Scoliosis 21.30 10.28 49 203553 2744 34750585
Medical device implantation 21.19 10.28 22 203580 604 34752725
Skin cancer 21.17 10.28 117 203485 10180 34743149
Foetal disorder 21.01 10.28 25 203577 801 34752528
Ankylosing spondylitis 20.88 10.28 76 203526 5528 34747801
Incorrect route of product administration 20.74 10.28 34 203568 14811 34738518
Latent tuberculosis 20.55 10.28 32 203570 1331 34751998
Sleep disorder due to a general medical condition 20.46 10.28 3 203599 5218 34748111
Congenital myopia 20.33 10.28 10 203592 77 34753252
Vomiting 20.10 10.28 1209 202393 246412 34506917
Folate deficiency 20.06 10.28 30 203572 1204 34752125
Joint stiffness 20.04 10.28 120 203482 10753 34742576
Body temperature decreased 19.81 10.28 137 203465 12897 34740432
Intentional self-injury 19.74 10.28 31 203571 13740 34739589
Therapeutic product effect decreased 19.72 10.28 298 203304 34445 34718884
Fall 19.66 10.28 1403 202199 201482 34551847
Dyslexia 19.66 10.28 16 203586 318 34753011
Congenital foot malformation 19.58 10.28 18 203584 424 34752905
Prognathism 19.52 10.28 11 203591 115 34753214
Haematochezia 19.48 10.28 380 203222 46154 34707175
Multiple congenital abnormalities 19.41 10.28 20 203582 544 34752785
Limb reduction defect 19.40 10.28 15 203587 276 34753053
Haematocrit decreased 19.34 10.28 279 203323 31937 34721392
Congenital astigmatism 19.26 10.28 9 203593 61 34753268
Radiation inflammation 19.19 10.28 25 203577 880 34752449
Anaphylactic shock 19.17 10.28 40 203562 15901 34737428
Ankyloglossia congenital 19.13 10.28 15 203587 282 34753047
Hypermetropia 19.11 10.28 19 203583 495 34752834
Post procedural infection 19.07 10.28 67 203535 4789 34748540
Cleft palate 18.90 10.28 21 203581 624 34752705
Foetal heart rate deceleration abnormality 18.89 10.28 19 203583 502 34752827
Oropharyngeal pain 18.86 10.28 301 203301 35184 34718145
Clinodactyly 18.80 10.28 14 203588 243 34753086
Akathisia 18.79 10.28 12 203590 8097 34745232
Enuresis 18.74 10.28 42 203560 2311 34751018
Blood pressure diastolic increased 18.60 10.28 68 203534 4957 34748372
Serum ferritin increased 18.55 10.28 78 203524 6068 34747261
Kinematic imbalances due to suboccipital strain 18.39 10.28 6 203596 12 34753317
Constipation 18.17 10.28 634 202968 136348 34616981
Strabismus congenital 18.16 10.28 7 203595 27 34753302
Aspergillus infection 18.13 10.28 27 203575 12227 34741102
Colorectal cancer 18.06 10.28 3 203599 4758 34748571
Suspected suicide 17.99 10.28 3 203599 4745 34748584
Oesophageal fibrosis 17.94 10.28 12 203590 174 34753155
Neonatal respiratory distress 17.85 10.28 20 203582 600 34752729
Pyelocaliectasis 17.70 10.28 27 203575 1103 34752226
Pulmonary artery stenosis congenital 17.67 10.28 18 203584 483 34752846
Tooth malformation 17.65 10.28 12 203590 179 34753150
Tachycardia 17.62 10.28 368 203234 84404 34668925
Congenital bladder anomaly 17.60 10.28 14 203588 269 34753060
Congenital anomaly 17.35 10.28 30 203572 1363 34751966
Kyphosis congenital 17.32 10.28 5 203597 5 34753324
Lung neoplasm malignant 17.29 10.28 166 203436 17229 34736100
Floppy infant 17.23 10.28 10 203592 111 34753218
Product quality issue 17.11 10.28 47 203555 16988 34736341
Umbilical hernia 17.07 10.28 63 203539 4614 34748715
Dermatitis psoriasiform 17.06 10.28 31 203571 1465 34751864
Urticaria 17.02 10.28 258 203344 62119 34691210
Maternal exposure before pregnancy 17.00 10.28 22 203580 769 34752560
Spinal disorder 16.99 10.28 59 203543 4193 34749136
Arthritis infective 16.88 10.28 51 203551 3368 34749961
Stevens-Johnson syndrome 16.86 10.28 54 203548 18585 34734744
Cystitis haemorrhagic 16.84 10.28 6 203596 5673 34747656
Hyperammonaemia 16.82 10.28 8 203594 6359 34746970
Epispadias 16.78 10.28 11 203591 154 34753175
Red blood cell sedimentation rate 16.68 10.28 27 203575 1161 34752168
Hernia congenital 16.61 10.28 4 203598 0 34753329
Granuloma skin 16.53 10.28 28 203574 1251 34752078
Sexual dysfunction 16.52 10.28 8 203594 6295 34747034
Inguinal hernia 16.50 10.28 88 203514 7553 34745776
Camptodactyly congenital 16.49 10.28 10 203592 121 34753208
Ear malformation 16.36 10.28 14 203588 299 34753030
Prominent epicanthal folds 16.19 10.28 11 203591 164 34753165
Vitamin B12 deficiency 16.16 10.28 56 203546 3975 34749354
Fine motor delay 16.12 10.28 13 203589 255 34753074
Blood parathyroid hormone decreased 16.03 10.28 30 203572 1450 34751879
Malignant melanoma 16.02 10.28 91 203511 7999 34745330
Immunosuppression 16.01 10.28 76 203526 6228 34747101
Squamous cell carcinoma of lung 16.01 10.28 35 203567 1894 34751435
Ventricular tachycardia 16.00 10.28 90 203512 26489 34726840
Kyphosis 15.89 10.28 27 203575 1209 34752120
Crohn's disease 15.86 10.28 47 203555 3070 34750259
Diverticular perforation 15.82 10.28 50 203552 3384 34749945
Unresponsive to stimuli 15.72 10.28 95 203507 27474 34725855
Encopresis 15.58 10.28 11 203591 175 34753154
Arthritis bacterial 15.57 10.28 65 203537 5041 34748288
Lacrimal disorder 15.50 10.28 14 203588 322 34753007
BK virus infection 15.48 10.28 7 203595 5731 34747598
Cleft lip 15.47 10.28 14 203588 323 34753006
Therapy partial responder 15.42 10.28 20 203582 9596 34743733
Back disorder 15.33 10.28 78 203524 6573 34746756
Pyloric stenosis 15.29 10.28 22 203580 852 34752477
Micropenis 15.29 10.28 7 203595 45 34753284
Juvenile idiopathic arthritis 15.27 10.28 34 203568 1863 34751466
Abortion spontaneous 15.26 10.28 15 203587 385 34752944
Immunodeficiency 15.24 10.28 68 203534 5430 34747899
Accessory spleen 15.07 10.28 10 203592 143 34753186
Cardiotoxicity 15.07 10.28 7 203595 5641 34747688
Nodule 15.05 10.28 79 203523 6740 34746589
Sinusitis 15.00 10.28 331 203271 41071 34712258
Transplant rejection 14.98 10.28 23 203579 10288 34743041
Drug level increased 14.89 10.28 72 203530 22024 34731305
Adenovirus infection 14.84 10.28 6 203596 5251 34748078
Microphthalmos 14.81 10.28 11 203591 190 34753139
Gastrointestinal infection 14.80 10.28 70 203532 5728 34747601
Visuospatial deficit 14.77 10.28 9 203593 110 34753219
Joint ankylosis 14.76 10.28 30 203572 1542 34751787
Hallucination 14.75 10.28 211 203391 51287 34702042
Synovial cyst 14.55 10.28 38 203564 2306 34751023
Poor venous access 14.28 10.28 64 203538 5119 34748210
Bronchial carcinoma 14.23 10.28 23 203579 988 34752341
Neck mass 14.23 10.28 30 203572 1583 34751746
Proteinuria 14.22 10.28 58 203544 18584 34734745
Hypotension 14.17 10.28 1105 202497 220544 34532785
Disseminated intravascular coagulation 14.17 10.28 72 203530 21744 34731585
Congenital cerebral cyst 14.16 10.28 5 203597 14 34753315
Glycosylated haemoglobin increased 14.09 10.28 28 203574 11332 34741997
Loss of consciousness 14.07 10.28 370 203232 82297 34671032
C-reactive protein decreased 14.05 10.28 34 203568 1968 34751361
Craniosynostosis 14.04 10.28 14 203588 366 34752963
Appendicitis 14.03 10.28 42 203560 14765 34738564
Poor sucking reflex 14.01 10.28 13 203589 310 34753019
Bursitis 14.01 10.28 66 203536 5392 34747937
Cerebral haemorrhage neonatal 13.92 10.28 12 203590 259 34753070
Localised infection 13.80 10.28 160 203442 17427 34735902
Tumour lysis syndrome 13.69 10.28 52 203550 17007 34736322
Oesophageal adenocarcinoma 13.65 10.28 21 203581 864 34752465
Infection 13.64 10.28 654 202948 90261 34663068
Cerebral ventricle dilatation 13.63 10.28 22 203580 944 34752385
Heart disease congenital 13.62 10.28 27 203575 1363 34751966
Hepatitis B reactivation 13.60 10.28 3 203599 3888 34749441
Gross motor delay 13.57 10.28 13 203589 323 34753006
Myopia 13.54 10.28 24 203578 1112 34752217
Arthrodesis 13.46 10.28 15 203587 447 34752882
Brain stem auditory evoked response abnormal 13.45 10.28 5 203597 17 34753312
Abnormal labour affecting foetus 13.45 10.28 5 203597 17 34753312
Asphyxia 13.42 10.28 12 203590 6823 34746506
Pulmonary valve stenosis congenital 13.31 10.28 9 203593 133 34753196
Communication disorder 13.28 10.28 39 203563 2535 34750794
Aorticopulmonary septal defect 13.23 10.28 5 203597 18 34753311
Loss of personal independence in daily activities 13.23 10.28 269 203333 32910 34720419
Obsessive-compulsive disorder 13.22 10.28 8 203594 5556 34747773
Intestinal stenosis 13.13 10.28 35 203567 2151 34751178
Coarctation of the aorta 13.12 10.28 15 203587 460 34752869
Hernia pain 13.11 10.28 12 203590 281 34753048
Haemangioma 13.08 10.28 32 203570 1865 34751464
Second primary malignancy 13.06 10.28 16 203586 7870 34745459
Arnold-Chiari malformation 13 10.28 13 203589 341 34752988
Anal atresia 12.94 10.28 12 203590 286 34753043
Pharyngeal disorder 12.94 10.28 19 203583 750 34752579
Pyrexia 12.93 10.28 1721 201881 331292 34422037
Cellulitis 12.71 10.28 401 203201 52550 34700779
Developmental hip dysplasia 12.70 10.28 12 203590 293 34753036
Rheumatoid lung 12.67 10.28 21 203581 921 34752408
Anti-cyclic citrullinated peptide antibody positive 12.61 10.28 31 203571 1812 34751517
Skin injury 12.55 10.28 36 203566 2309 34751020
Pulmonary valve stenosis 12.55 10.28 13 203589 356 34752973
Peritoneal tuberculosis 12.55 10.28 13 203589 356 34752973
Exposure to toxic agent 12.51 10.28 3 203599 3672 34749657
Fistula discharge 12.51 10.28 20 203582 851 34752478
Fatigue 12.51 10.28 2394 201208 368259 34385070
Umbilical granuloma 12.46 10.28 3 203599 0 34753329
Congenital megaureter 12.44 10.28 9 203593 149 34753180
Autoscopy 12.44 10.28 11 203591 246 34753083
Micrognathia 12.40 10.28 12 203590 302 34753027
Joint contracture 12.39 10.28 32 203570 1929 34751400
Dystonia 12.39 10.28 28 203574 10817 34742512
Cytomegalovirus viraemia 12.38 10.28 15 203587 7415 34745914
Scleroderma renal crisis 12.29 10.28 11 203591 250 34753079
Haemolysis 12.25 10.28 85 203517 8009 34745320
Cardiac septal defect 12.24 10.28 12 203590 307 34753022
Lower respiratory tract congestion 12.22 10.28 24 203578 1203 34752126
Oesophageal atresia 12.19 10.28 15 203587 498 34752831
Mania 12.18 10.28 23 203579 9488 34743841
Maternal exposure timing unspecified 12.15 10.28 13 203589 370 34752959
Congenital genital malformation 12.14 10.28 9 203593 155 34753174
Infective pulmonary exacerbation of cystic fibrosis 12.13 10.28 13 203589 6788 34746541
Psychomotor skills impaired 12.13 10.28 50 203552 3856 34749473
Bone cyst 12.12 10.28 28 203574 1572 34751757
Septic arthritis staphylococcal 12.12 10.28 15 203587 501 34752828
Cytomegalovirus chorioretinitis 12.08 10.28 3 203599 3586 34749743
Hepatitis E antibody positive 12.08 10.28 11 203591 256 34753073
Dermatitis acneiform 11.99 10.28 11 203591 6178 34747151
Duodenal atresia 11.94 10.28 4 203598 9 34753320
Acquired plagiocephaly 11.90 10.28 6 203596 49 34753280
Hepatic enzyme increased 11.89 10.28 305 203297 38775 34714554
Pseudolymphoma 11.88 10.28 17 203585 655 34752674
Complications of transplanted kidney 11.86 10.28 6 203596 4603 34748726
Cholelithiasis 11.85 10.28 181 203421 20967 34732362
Muscle tone disorder 11.81 10.28 9 203593 162 34753167
Abnormal behaviour 11.77 10.28 91 203511 24878 34728451
Aggression 11.74 10.28 158 203444 38806 34714523
End stage renal disease 11.73 10.28 21 203581 8840 34744489
Endophthalmitis 11.68 10.28 3 203599 3505 34749824
Dactylitis 11.67 10.28 20 203582 902 34752427
Respiratory rate increased 11.67 10.28 98 203504 9796 34743533
Temperature regulation disorder 11.64 10.28 18 203584 744 34752585
Influenza 11.62 10.28 375 203227 49291 34704038
Myasthenia gravis 11.58 10.28 14 203588 6926 34746403
Kidney infection 11.57 10.28 62 203540 5332 34747997
Foetal distress syndrome 11.55 10.28 22 203580 1078 34752251
Ligament laxity 11.49 10.28 5 203597 28 34753301
Meconium in amniotic fluid 11.49 10.28 5 203597 28 34753301
Drug use disorder 11.48 10.28 5 203597 4186 34749143
Hypotelorism of orbit 11.45 10.28 8 203594 125 34753204
Central nervous system mass 11.44 10.28 9 203593 170 34753159
Diabetic ketoacidosis 11.44 10.28 60 203542 17972 34735357
Blood phosphorus increased 11.44 10.28 17 203585 7704 34745625
Pleural fibrosis 11.41 10.28 25 203577 1355 34751974
Withdrawal syndrome 11.32 10.28 36 203566 12419 34740910
Wall motion score index abnormal 11.31 10.28 9 203593 173 34753156
Erectile dysfunction 11.31 10.28 72 203530 20565 34732764
Body dysmorphic disorder 11.24 10.28 8 203594 129 34753200
Congenital eye disorder 11.24 10.28 8 203594 129 34753200
Poikiloderma 11.22 10.28 9 203593 175 34753154
Bronchitis 11.20 10.28 322 203280 41641 34711688
Learning disability 11.20 10.28 12 203590 342 34752987
Vascular insufficiency 11.20 10.28 12 203590 342 34752987
Pharyngitis 11.20 10.28 82 203520 7862 34745467
Cerebral haemorrhage 11.14 10.28 140 203462 34797 34718532
Neutropenia neonatal 11.13 10.28 17 203585 695 34752634
Skin indentation 11.13 10.28 4 203598 12 34753317
Osteonecrosis of jaw 11.08 10.28 60 203542 17829 34735500
Infantile apnoea 11.07 10.28 20 203582 941 34752388
Meningeal disorder 11.06 10.28 12 203590 347 34752982
Panniculitis 11.05 10.28 31 203571 1963 34751366
Blood insulin increased 11.03 10.28 12 203590 348 34752981
Hepatitis E virus test positive 11.02 10.28 11 203591 288 34753041
Nerve compression 11.00 10.28 43 203559 3236 34750093
Oxygen saturation decreased 11.00 10.28 400 203202 53418 34699911
Hepatic cyst 10.96 10.28 37 203565 2592 34750737
Accidental exposure to product 10.95 10.28 38 203564 12764 34740565
Placental insufficiency 10.92 10.28 7 203595 94 34753235
Personal relationship issue 10.92 10.28 11 203591 291 34753038
Peritoneal dialysis complication 10.91 10.28 28 203574 1681 34751648
Reticulocyte count increased 10.90 10.28 15 203587 557 34752772
Paradoxical drug reaction 10.90 10.28 3 203599 3348 34749981
Paranoia 10.89 10.28 35 203567 12033 34741296
Facial pain 10.83 10.28 4 203598 3700 34749629
Oropharyngeal discomfort 10.79 10.28 42 203560 3154 34750175
Spondyloarthropathy 10.75 10.28 16 203586 639 34752690
Congenital scoliosis 10.74 10.28 7 203595 97 34753232
Irritability 10.72 10.28 92 203510 24598 34728731
Potentiating drug interaction 10.69 10.28 8 203594 4969 34748360
Nose deformity 10.69 10.28 9 203593 188 34753141
Hypotony maculopathy 10.67 10.28 4 203598 14 34753315
Live birth 10.66 10.28 10 203592 242 34753087
Congenital mitral valve incompetence 10.64 10.28 8 203594 141 34753188
Lung cancer metastatic 10.56 10.28 38 203564 2749 34750580
Brain oedema 10.54 10.28 43 203559 13778 34739551
Nail pitting 10.54 10.28 11 203591 304 34753025
Gangrene neonatal 10.53 10.28 9 203593 192 34753137
Palindromic rheumatism 10.49 10.28 9 203593 193 34753136
Lactic acidosis 10.48 10.28 141 203461 34631 34718698
Autosomal chromosome anomaly 10.46 10.28 4 203598 15 34753314
Fistula 10.45 10.28 72 203530 6768 34746561
Scleroedema 10.45 10.28 5 203597 36 34753293
Aphthous ulcer 10.43 10.28 57 203545 4938 34748391
Nail bed bleeding 10.42 10.28 12 203590 371 34752958
Foetal hypokinesia 10.40 10.28 12 203590 372 34752957
Urinary tract malformation 10.39 10.28 3 203599 3 34753326
Flail chest 10.39 10.28 3 203599 3 34753326
Nocardiosis 10.38 10.28 5 203597 3946 34749383
Electrocardiogram QRS complex prolonged 10.34 10.28 8 203594 4886 34748443
Osteolysis 10.33 10.28 41 203561 3107 34750222
Frequent bowel movements 10.33 10.28 117 203485 12670 34740659
Necrotising fasciitis streptococcal 10.31 10.28 8 203594 148 34753181

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1251.38 9.71 157 579998 245610 78918623
Rheumatoid arthritis 1165.65 9.71 3750 576405 204720 78959513
Toxicity to various agents 1051.56 9.71 913 579242 420627 78743606
Arthropathy 870.10 9.71 3051 577104 174060 78990173
Pemphigus 861.02 9.71 2100 578055 97482 79066751
Systemic lupus erythematosus 858.59 9.71 2371 577784 118778 79045455
Hand deformity 833.91 9.71 2130 578025 101789 79062444
Joint swelling 821.37 9.71 4209 575946 284437 78879796
Synovitis 802.87 9.71 2668 577487 148066 79016167
Drug abuse 783.09 9.71 123 580032 162568 79001665
Glossodynia 742.65 9.71 2033 578122 101304 79062929
Maternal exposure during pregnancy 681.51 9.71 2365 577790 134173 79030060
Arthralgia 649.68 9.71 6681 573474 565122 78599111
Anti-cyclic citrullinated peptide antibody positive 633.86 9.71 1672 578483 81471 79082762
Wound 627.04 9.71 2066 578089 114113 79050120
Pericarditis 574.49 9.71 1867 578288 102369 79061864
Infusion related reaction 547.83 9.71 3199 576956 227038 78937195
Abdominal discomfort 497.34 9.71 3325 576830 247402 78916831
Discomfort 464.92 9.71 1979 578176 123638 79040595
Pain 461.61 9.71 7431 572724 696371 78467862
Swelling 457.78 9.71 2920 577235 213791 78950442
Death 455.68 9.71 2347 577808 564167 78600066
Therapeutic product effect decreased 453.94 9.71 2373 577782 161490 79002743
Alopecia 445.53 9.71 3046 577109 228309 78935924
Intentional overdose 424.33 9.71 122 580033 105838 79058395
Exposure during pregnancy 417.46 9.71 1648 578507 99484 79064749
Musculoskeletal stiffness 407.24 9.71 2418 577737 172590 78991643
Duodenal ulcer perforation 399.63 9.71 1224 578931 64987 79099246
Helicobacter infection 392.55 9.71 1258 578897 68446 79095787
Drug interaction 391.09 9.71 1623 578532 413560 78750673
Rheumatoid factor positive 377.89 9.71 1124 579031 58715 79105518
Contraindicated product administered 377.73 9.71 2194 577961 155344 79008889
Nasopharyngitis 351.56 9.71 3096 577059 250785 78913448
Psoriatic arthropathy 348.89 9.71 1304 578851 76695 79087538
Hepatic enzyme increased 340.62 9.71 2386 577769 180224 78984009
Drug intolerance 324.39 9.71 3139 577016 260980 78903253
Febrile neutropenia 321.38 9.71 756 579399 230243 78933990
Impaired healing 270.45 9.71 1309 578846 86346 79077887
Sickle cell anaemia with crisis 262.55 9.71 306 579849 7616 79156617
Cardiac arrest 254.17 9.71 545 579610 171551 78992682
Suicide attempt 243.36 9.71 151 580004 82781 79081452
Overdose 238.08 9.71 626 579529 183580 78980653
Depressed level of consciousness 220.84 9.71 226 579929 96426 79067807
Peripheral swelling 218.69 9.71 2956 577199 266661 78897572
C-reactive protein abnormal 218.23 9.71 811 579344 47556 79116677
Muscle injury 215.56 9.71 810 579345 47751 79116482
Folliculitis 215.30 9.71 886 579269 54494 79109739
Gestational diabetes 211.77 9.71 245 579910 6048 79158185
Hypersensitivity 209.35 9.71 2867 577288 259372 78904861
Sinusitis 206.25 9.71 2253 577902 193248 78970985
Irritable bowel syndrome 201.79 9.71 943 579212 61298 79102935
Acute kidney injury 198.22 9.71 2626 577529 516778 78647455
Red blood cell sedimentation rate abnormal 194.94 9.71 455 579700 20508 79143725
Disease progression 193.67 9.71 689 579466 183673 78980560
Blister 192.40 9.71 1508 578647 117968 79046265
Product use issue 191.84 9.71 2352 577803 207470 78956763
Lower respiratory tract infection 190.25 9.71 1598 578557 127622 79036611
Sleep disorder due to general medical condition, insomnia type 189.59 9.71 722 579433 42834 79121399
Arthritis 189.43 9.71 1458 578697 113422 79050811
Knee arthroplasty 189.16 9.71 718 579437 42530 79121703
Rhabdomyolysis 188.64 9.71 286 579869 102845 79061388
Treatment failure 188.30 9.71 1983 578172 168503 78995730
Sedation 186.32 9.71 72 580083 51823 79112410
Malignant neoplasm progression 178.85 9.71 458 579697 135532 79028701
Bradycardia 177.16 9.71 458 579697 135099 79029134
Osteoarthritis 176.46 9.71 1164 578991 86145 79078088
Respiratory arrest 175.58 9.71 100 580055 57450 79106783
Abortion spontaneous 172.90 9.71 540 579615 28967 79135266
Hip arthroplasty 167.57 9.71 607 579548 35149 79129084
Blood pressure fluctuation 163.30 9.71 939 579216 66206 79098027
Drug reaction with eosinophilia and systemic symptoms 162.36 9.71 137 580018 64107 79100126
Weight increased 158.74 9.71 2868 577287 274518 78889715
Renal failure 144.42 9.71 863 579292 200105 78964128
Drug resistance 144.36 9.71 63 580092 42150 79122083
Psoriasis 143.24 9.71 1129 579026 88458 79075775
Rheumatic fever 142.90 9.71 495 579660 28030 79136203
Pregnancy 141.58 9.71 474 579681 26377 79137856
Cardio-respiratory arrest 136.93 9.71 373 579782 108137 79056096
Intentional product misuse 135.00 9.71 308 579847 94857 79069376
Serotonin syndrome 134.86 9.71 80 580075 44947 79119286
Agitation 134.85 9.71 331 579824 99384 79064849
Multiple organ dysfunction syndrome 134.67 9.71 437 579718 119809 79044424
Hepatic function abnormal 133.43 9.71 203 579952 72904 79091329
Constipation 130.12 9.71 1373 578782 281677 78882556
Coma 129.25 9.71 343 579812 100306 79063927
Red blood cell sedimentation rate increased 126.12 9.71 664 579491 45278 79118955
Contusion 125.80 9.71 1644 578511 147132 79017101
Drug dependence 125.57 9.71 70 580085 40699 79123534
Fibromyalgia 123.52 9.71 847 579308 63493 79100740
Respiratory failure 121.12 9.71 794 579361 180117 78984116
Ill-defined disorder 121.06 9.71 858 579297 65017 79099216
Hepatic failure 119.58 9.71 162 579993 61050 79103183
Blood pressure systolic abnormal 119.49 9.71 335 579820 16912 79147321
Infection 119.41 9.71 2444 577711 239268 78924965
Swollen joint count increased 119.35 9.71 403 579752 22524 79141709
Electrocardiogram QT prolonged 119.14 9.71 304 579851 90082 79074151
Blood pressure diastolic abnormal 117.70 9.71 357 579798 18845 79145388
C-reactive protein increased 117.25 9.71 1445 578710 127582 79036651
Joint effusion 116.18 9.71 341 579814 17673 79146560
Blood pressure systolic increased 115.92 9.71 860 579295 66126 79098107
Neutropenia 115.67 9.71 1438 578717 286272 78877961
Somnolence 114.42 9.71 1148 579007 237833 78926400
Cardiac failure 114.37 9.71 659 579496 154183 79010050
Lactic acidosis 113.08 9.71 212 579943 70147 79094086
Condition aggravated 112.98 9.71 4587 575568 496537 78667696
Hypotension 112.72 9.71 2394 577761 437923 78726310
Intentional self-injury 108.32 9.71 50 580105 32369 79131864
Product use in unapproved indication 105.31 9.71 1239 578916 249120 78915113
Inflammation 105.09 9.71 1094 579061 92659 79071574
Poisoning 105.09 9.71 27 580128 25245 79138988
Renal impairment 103.84 9.71 696 579459 157087 79007146
Neoplasm progression 103.79 9.71 134 580021 51548 79112685
Sopor 101.20 9.71 57 580098 32953 79131280
Hypoglycaemia 101.18 9.71 388 579767 101206 79063027
Cytomegalovirus infection 100.51 9.71 97 580058 42547 79121686
Hyponatraemia 99.16 9.71 822 579333 177026 78987207
Grip strength decreased 97.22 9.71 365 579790 21504 79142729
Fatigue 96.54 9.71 7931 572224 921796 78242437
Hyperhidrosis 95.85 9.71 676 579479 150816 79013417
Hyperglycaemia 95.47 9.71 233 579922 70102 79094131
Tachycardia 95.36 9.71 830 579325 176938 78987295
Respiratory depression 94.85 9.71 41 580114 27589 79136644
Pancytopenia 94.10 9.71 1712 578443 164033 79000200
Angioedema 93.96 9.71 264 579891 75771 79088462
Stomatitis 92.70 9.71 1542 578613 145215 79019018
Musculoskeletal pain 91.13 9.71 1142 579013 101212 79063021
Osteoporosis 90.96 9.71 690 579465 53422 79110811
Rash 90.42 9.71 5106 575049 573252 78590981
Enthesopathy 88.95 9.71 234 579921 11374 79152859
Rheumatoid nodule 88.56 9.71 304 579851 17134 79147099
Live birth 86.80 9.71 317 579838 18427 79145806
Foot deformity 86.44 9.71 376 579779 23698 79140535
Blood creatine phosphokinase increased 85.01 9.71 225 579930 65865 79098368
Disability assessment scale score increased 84.94 9.71 115 580040 3343 79160890
Caesarean section 84.42 9.71 241 579914 12294 79151939
Altered state of consciousness 83.57 9.71 118 580037 43704 79120529
Blood pressure diastolic decreased 83.13 9.71 437 579718 29779 79134454
Pain in extremity 82.32 9.71 3338 576817 361200 78803033
Injection site erythema 82.28 9.71 901 579254 77296 79086937
Drug ineffective for unapproved indication 80.92 9.71 156 579999 51082 79113151
Basal cell carcinoma 80.84 9.71 507 579648 36868 79127365
Juvenile idiopathic arthritis 80.55 9.71 133 580022 4630 79159603
Neuroleptic malignant syndrome 78.34 9.71 52 580103 27507 79136726
Shock 77.48 9.71 123 580032 43425 79120808
Sedation complication 77.28 9.71 11 580144 15658 79148575
Ventricular fibrillation 77.14 9.71 71 580084 31855 79132378
Polyarthritis 76.80 9.71 229 579926 11973 79152260
Neurotoxicity 76.60 9.71 74 580081 32444 79131789
Tenosynovitis 76.25 9.71 268 579887 15286 79148947
Palmar-plantar erythrodysaesthesia syndrome 76.21 9.71 77 580078 33057 79131176
Bone erosion 76.14 9.71 294 579861 17553 79146680
Joint range of motion decreased 74.19 9.71 455 579700 32827 79131406
Ventricular tachycardia 74.08 9.71 119 580036 41816 79122417
Drug withdrawal syndrome 71.82 9.71 88 580067 34630 79129603
Gastrointestinal disorder 71.72 9.71 1269 578886 120936 79043297
Cardiac failure congestive 71.51 9.71 676 579479 141726 79022507
Neuropathy peripheral 71.30 9.71 670 579485 140635 79023598
Hypoxia 70.65 9.71 450 579705 102793 79061440
Joint stiffness 70.52 9.71 524 579631 40306 79123927
Myocardial infarction 69.98 9.71 931 579224 183198 78981035
Heart rate decreased 69.35 9.71 800 579355 69516 79094717
Joint destruction 69.21 9.71 141 580014 5784 79158449
Blood cholesterol increased 68.18 9.71 919 579236 82801 79081432
Acute hepatic failure 68.10 9.71 71 580084 30042 79134191
Disseminated intravascular coagulation 67.86 9.71 97 580058 35745 79128488
Injection site pruritus 67.08 9.71 532 579623 41751 79122482
Injection site reaction 67.02 9.71 651 579504 54134 79110099
Cardiogenic shock 64.98 9.71 129 580026 41785 79122448
Syncope 64.72 9.71 917 579238 178532 78985701
Cognitive disorder 64.61 9.71 275 579880 69651 79094582
Post transplant lymphoproliferative disorder 64.34 9.71 5 580150 11459 79152774
Metabolic acidosis 63.76 9.71 346 579809 82183 79082050
Pulmonary fibrosis 62.49 9.71 541 579614 43571 79120662
Anaphylactic shock 61.86 9.71 104 580051 35892 79128341
Hallucination 61.65 9.71 368 579787 85377 79078856
Intentional product use issue 60.86 9.71 1493 578662 150619 79013614
Joint laxity 60.71 9.71 80 580075 2264 79161969
Localised infection 59.19 9.71 472 579683 37103 79127130
Neutrophil count decreased 59.06 9.71 420 579735 93539 79070694
Seizure 58.92 9.71 992 579163 187842 78976391
Pathogen resistance 56.50 9.71 17 580138 14325 79149908
Mydriasis 56.23 9.71 29 580126 17614 79146619
Latent tuberculosis 55.86 9.71 93 580062 3260 79160973
Substance abuse 55.30 9.71 6 580149 10520 79153713
Myalgia 55.10 9.71 984 579171 184657 78979576
Orthostatic hypotension 54.94 9.71 216 579939 55948 79108285
Tremor 54.87 9.71 888 579267 169195 78995038
Abnormal behaviour 54.84 9.71 114 580041 36307 79127926
Loss of personal independence in daily activities 54.53 9.71 1049 579106 101531 79062702
Cytokine release syndrome 53.93 9.71 113 580042 35885 79128348
Nodule 52.93 9.71 317 579838 22677 79141556
Nausea 52.77 9.71 6129 574026 951067 78213166
Creatinine renal clearance decreased 52.48 9.71 37 580118 18965 79145268
Psychotic disorder 52.45 9.71 142 580013 41260 79122973
Aspergillus infection 52.02 9.71 38 580117 19123 79145110
Blood glucose increased 51.83 9.71 560 579595 114415 79049818
Immune reconstitution inflammatory syndrome 51.71 9.71 18 580137 13823 79150410
Acute chest syndrome 51.23 9.71 60 580095 1501 79162732
Ascites 50.85 9.71 331 579824 75231 79089002
No adverse event 50.63 9.71 123 580032 37069 79127164
Torsade de pointes 50.25 9.71 40 580115 19272 79144961
Drug level increased 50.23 9.71 136 580019 39515 79124718
Suicidal ideation 50.07 9.71 337 579818 76003 79088230
Venoocclusive liver disease 50.06 9.71 12 580143 11759 79152474
Pre-eclampsia 49.99 9.71 138 580017 6903 79157330
Akathisia 49.96 9.71 17 580138 13242 79150991
General physical health deterioration 49.71 9.71 2464 577691 272774 78891459
Diabetic ketoacidosis 49.55 9.71 109 580046 34013 79130220
Injection site swelling 49.54 9.71 543 579612 46589 79117644
Tendonitis 49.52 9.71 320 579835 23510 79140723
Disability 49.45 9.71 251 579904 16869 79147364
Blood pressure diastolic increased 49.09 9.71 223 579932 14319 79149914
Tuberculosis 49.04 9.71 230 579925 14968 79149265
Vomiting 49.03 9.71 4174 575981 661654 78502579
Injection site pain 48.86 9.71 1264 578891 128574 79035659
Red blood cell sedimentation rate 48.72 9.71 118 580037 5447 79158786
Premature delivery 48.69 9.71 315 579840 23152 79141081
Encephalopathy 48.58 9.71 289 579866 67108 79097125
Unresponsive to stimuli 48.16 9.71 225 579930 55563 79108670
Fracture 47.93 9.71 297 579858 21504 79142729
Drug use disorder 47.92 9.71 4 580151 8647 79155586
Appendicolith 47.24 9.71 4 580151 8547 79155686
Thrombocytopenia 47.11 9.71 1520 578635 263739 78900494
Tongue disorder 46.95 9.71 214 579941 13761 79150472
Wrong technique in product usage process 46.53 9.71 330 579825 73545 79090688
Skin ulcer 46.41 9.71 600 579555 53550 79110683
Alanine aminotransferase abnormal 46.27 9.71 156 579999 8711 79155522
Exposure to toxic agent 46.19 9.71 6 580149 9152 79155081
Transplant rejection 46.05 9.71 44 580111 19393 79144840
Haematotoxicity 45.87 9.71 28 580127 15491 79148742
Femur fracture 45.67 9.71 456 579699 38196 79126037
Speech disorder 45.59 9.71 222 579933 54223 79110010
Dystonia 45.58 9.71 53 580102 21346 79142887
Ear infection 45.53 9.71 416 579739 34016 79130217
Premature rupture of membranes 45.38 9.71 95 580060 3974 79160259
Anxiety 45.35 9.71 1419 578736 247093 78917140
Mobility decreased 45.28 9.71 1187 578968 120988 79043245
Type 2 diabetes mellitus 45.26 9.71 624 579531 56498 79107735
Inappropriate antidiuretic hormone secretion 45.24 9.71 76 580079 26237 79137996
Second primary malignancy 45.12 9.71 24 580131 14326 79149907
Tumour lysis syndrome 45.11 9.71 65 580090 23874 79140359
Premature labour 45.02 9.71 149 580006 8241 79155992
Sepsis 45.00 9.71 1556 578599 267872 78896361
Synovial cyst 44.75 9.71 168 579987 9897 79154336
Blood creatinine increased 44.71 9.71 826 579329 154231 79010002
Cerebral infarction 44.46 9.71 176 579979 45500 79118733
Asphyxia 44.20 9.71 15 580140 11705 79152528
Maternal exposure before pregnancy 44.07 9.71 98 580057 4275 79159958
Mucormycosis 44.06 9.71 5 580150 8464 79155769
Off label use 43.50 9.71 5861 574294 901354 78262879
Laryngitis 43.45 9.71 231 579924 15808 79148425
Brain oedema 43.40 9.71 73 580082 25190 79139043
Body temperature decreased 43.34 9.71 390 579765 31755 79132478
Extrapyramidal disorder 43.31 9.71 61 580094 22618 79141615
Withdrawal syndrome 43.06 9.71 81 580074 26773 79137460
Bursitis 42.90 9.71 424 579731 35420 79128813
Myelosuppression 42.67 9.71 150 580005 40146 79124087
Restlessness 42.24 9.71 184 579971 46308 79117925
Adverse event 41.87 9.71 643 579512 59571 79104662
Irritability 41.68 9.71 156 579999 40988 79123245
Cerebral haemorrhage 41.20 9.71 248 579907 57425 79106808
Disturbance in attention 40.90 9.71 210 579945 50591 79113642
Toxic epidermal necrolysis 40.77 9.71 176 579979 44405 79119828
Disorientation 40.73 9.71 278 579877 62498 79101735
Foetal exposure during pregnancy 40.64 9.71 113 580042 5677 79158556
Respiratory distress 40.56 9.71 253 579902 58086 79106147
Proteinuria 40.03 9.71 113 580042 32389 79131844
Vision blurred 40.01 9.71 536 579619 105362 79058871
Oropharyngeal pain 39.82 9.71 1060 579095 108293 79055940
Hypothermia 39.75 9.71 65 580090 22681 79141552
Blood pressure increased 39.58 9.71 1899 578256 209461 78954772
BK virus infection 39.41 9.71 8 580147 8796 79155437
Balance disorder 39.32 9.71 495 579660 98362 79065871
Anaphylactic reaction 39.32 9.71 404 579751 83339 79080894
Unintentional medical device removal 39.02 9.71 5 580150 7707 79156526
Coronary artery disease 38.59 9.71 298 579857 65176 79099057
Tenderness 38.35 9.71 299 579856 23343 79140890
Miosis 38.28 9.71 35 580120 15754 79148479
Dyspnoea 38.22 9.71 5561 574594 851464 78312769
Posterior reversible encephalopathy syndrome 38.12 9.71 84 580071 26197 79138036
Neck deformity 37.60 9.71 56 580099 1781 79162452
Loss of consciousness 37.54 9.71 932 579223 167011 78997222
Mental status changes 37.51 9.71 309 579846 66650 79097583
Coagulopathy 37.48 9.71 135 580020 35871 79128362
Forced expiratory volume decreased 37.36 9.71 6 580149 7808 79156425
Myoclonus 37.24 9.71 92 580063 27568 79136665
Mania 37.02 9.71 47 580108 18213 79146020
Thrombotic microangiopathy 36.80 9.71 56 580099 20113 79144120
Injection site bruising 36.70 9.71 458 579697 40544 79123689
Multiple fractures 36.54 9.71 135 580020 7891 79156342
Colorectal cancer 36.41 9.71 9 580146 8638 79155595
Blood parathyroid hormone decreased 35.89 9.71 162 579993 10374 79153859
Hyperkalaemia 35.65 9.71 601 579554 113797 79050436
Graft versus host disease 35.61 9.71 34 580121 14992 79149241
Herpes zoster 35.54 9.71 908 579247 92175 79072058
Paradoxical drug reaction 35.54 9.71 5 580150 7180 79157053
Haemorrhage intracranial 35.36 9.71 87 580068 26106 79138127
Drug ineffective 35.28 9.71 8615 571540 1072298 78091935
Acute graft versus host disease 35.04 9.71 15 580140 10152 79154081
Aggression 34.91 9.71 222 579933 50736 79113497
Ejection fraction decreased 34.45 9.71 132 580023 34445 79129788
Atrial fibrillation 34.39 9.71 1137 579018 196749 78967484
Granuloma skin 34.25 9.71 145 580010 9029 79155204
Bronchopulmonary aspergillosis 34.23 9.71 69 580086 22225 79142008
Neck mass 33.97 9.71 89 580066 4315 79159918
Skin papilloma 33.81 9.71 107 580048 5779 79158454
Exostosis 33.58 9.71 224 579931 16634 79147599
Arthritis infective 33.46 9.71 134 580021 8137 79156096
Dyskinesia 33.33 9.71 190 579965 44583 79119650
Ankylosing spondylitis 33.21 9.71 176 579979 12029 79152204
Delirium 33.19 9.71 425 579730 84202 79080031
Hypokalaemia 33.10 9.71 796 579359 143244 79020989
Dysarthria 33.09 9.71 323 579832 67299 79096934
Wheelchair user 32.99 9.71 109 580046 6023 79158210
Acute respiratory distress syndrome 32.80 9.71 187 579968 43880 79120353
Cerebrovascular accident 32.78 9.71 869 579286 154423 79009810
Platelet count decreased 32.77 9.71 1123 579032 193541 78970692
Muscle rigidity 32.74 9.71 59 580096 19823 79144410
Bronchospasm 32.45 9.71 84 580071 24775 79139458
Limb deformity 32.37 9.71 77 580078 3513 79160720
Cholestasis 32.22 9.71 234 579921 51875 79112358
Facet joint syndrome 32.15 9.71 165 579990 11137 79153096
Peripheral venous disease 32.06 9.71 212 579943 15697 79148536
Lip dry 32.01 9.71 207 579948 15211 79149022
Malignant melanoma 31.89 9.71 200 579955 14541 79149692
Lupus-like syndrome 31.87 9.71 191 579964 13666 79150567
Disease recurrence 31.86 9.71 189 579966 43920 79120313
Pulmonary oedema 31.79 9.71 451 579704 87803 79076430
Emotional distress 31.74 9.71 166 579989 39803 79124430
Spinal stenosis 31.56 9.71 210 579945 15581 79148652
Adenovirus infection 31.53 9.71 11 580144 8436 79155797
Dehydration 31.39 9.71 1480 578675 246707 78917526
Joint dislocation 31.32 9.71 221 579934 16718 79147515
Fear 31.29 9.71 71 580084 21915 79142318
Arrhythmia 31.11 9.71 290 579865 60982 79103251
Ulcer 30.90 9.71 344 579811 29628 79134605
Status epilepticus 30.89 9.71 87 580068 24954 79139279
Product quality issue 30.42 9.71 135 580020 33805 79130428
Smear cervix abnormal 30.40 9.71 61 580094 2475 79161758
Gastroenteritis viral 30.33 9.71 295 579860 24536 79139697
Maternal exposure timing unspecified 30.31 9.71 102 580053 5690 79158543
Joint injury 30.22 9.71 355 579800 30980 79133253
Injection site rash 30.20 9.71 229 579926 17725 79146508
Fear of injection 30.17 9.71 121 580034 7353 79156880
Panniculitis 30.06 9.71 173 579982 12198 79152035
Bronchitis 30.04 9.71 1199 578956 129445 79034788
Therapeutic response decreased 29.74 9.71 666 579489 66187 79098046
Acidosis 29.63 9.71 62 580093 19700 79144533
Scleritis 29.58 9.71 84 580071 4272 79159961
Chest discomfort 29.53 9.71 771 579384 137273 79026960
Mouth ulceration 29.44 9.71 417 579738 37977 79126256
Hydrops foetalis 29.09 9.71 32 580123 746 79163487
Lymphocyte count decreased 28.93 9.71 213 579942 47076 79117157
Skin cancer 28.86 9.71 198 579957 14842 79149391
White blood cell count decreased 28.80 9.71 1099 579056 187189 78977044
Anuria 28.79 9.71 69 580086 20894 79143339
Malignant mediastinal neoplasm 28.77 9.71 43 580112 1372 79162861
Stevens-Johnson syndrome 28.73 9.71 167 579988 38999 79125234
Rotator cuff repair 28.69 9.71 50 580105 1820 79162413
Device difficult to use 28.67 9.71 33 580122 13352 79150881
Glycosylated haemoglobin increased 28.40 9.71 61 580094 19199 79145034
Klebsiella infection 28.34 9.71 44 580111 15676 79148557
Multiple sclerosis relapse 28.27 9.71 210 579945 46323 79117910
Pneumatosis intestinalis 28.25 9.71 6 580149 6391 79157842
Normal newborn 28.15 9.71 114 580041 6958 79157275
Blood bilirubin increased 28.10 9.71 327 579828 65905 79098328
Nocardiosis 27.98 9.71 4 580151 5675 79158558
Chronic kidney disease 27.92 9.71 327 579828 65827 79098406
Small for dates baby 27.88 9.71 25 580130 451 79163782
Wound infection 27.84 9.71 282 579873 23709 79140524
Erythema multiforme 27.64 9.71 54 580101 17597 79146636
Sciatica 27.58 9.71 366 579789 32856 79131377
Sexual dysfunction 27.48 9.71 11 580144 7752 79156481
Retinitis 27.46 9.71 97 580058 5546 79158687
Blood pressure decreased 27.39 9.71 534 579621 98932 79065301
Accidental exposure to product 27.23 9.71 126 580029 31196 79133037
Deep vein thrombosis postoperative 27.20 9.71 152 580003 10600 79153633
Metastases to bone 27.17 9.71 89 580066 24338 79139895
Anti-cyclic citrullinated peptide antibody 27.12 9.71 99 580056 5753 79158480
Cytomegalovirus viraemia 27.04 9.71 32 580123 12789 79151444
Muscle twitching 27.02 9.71 91 580064 24673 79139560
Psychomotor hyperactivity 26.86 9.71 51 580104 16798 79147435
Clostridium difficile colitis 26.81 9.71 132 580023 32151 79132082
Sinus tachycardia 26.74 9.71 158 579997 36750 79127483
Haemorrhage 26.69 9.71 484 579671 90634 79073599
Cleft lip and palate 26.61 9.71 29 580126 669 79163564
Cytopenia 26.51 9.71 69 580086 20314 79143919
Cystitis haemorrhagic 26.48 9.71 17 580138 9155 79155078
Cardiotoxicity 26.41 9.71 30 580125 12209 79152024
Bone disorder 26.33 9.71 233 579922 18880 79145353
Infective pulmonary exacerbation of cystic fibrosis 26.13 9.71 33 580122 12818 79151415
Rheumatoid lung 26.09 9.71 79 580076 4166 79160067
Hypomagnesaemia 26.04 9.71 217 579938 46694 79117539
Urticaria 25.95 9.71 1092 579063 184109 78980124
Blood calcium decreased 25.92 9.71 131 580024 31688 79132545
Dermatitis acneiform 25.63 9.71 21 580134 9972 79154261
Tenosynovitis stenosans 25.60 9.71 64 580091 3014 79161219
Tachypnoea 25.55 9.71 133 580022 31930 79132303
Leukocytosis 25.51 9.71 198 579957 43257 79120976
Anaemia 25.48 9.71 2841 577314 442174 78722059
Adjustment disorder with depressed mood 25.40 9.71 132 580023 8954 79155279
Gastrointestinal haemorrhage 25.36 9.71 850 579305 146869 79017364
Angina pectoris 25.35 9.71 247 579908 51485 79112748
Foot fracture 25.33 9.71 258 579897 21723 79142510
Device use error 25.24 9.71 10 580145 7091 79157142
Antinuclear antibody positive 25.16 9.71 119 580036 7771 79156462
Synovial fluid analysis 25.06 9.71 54 580101 2305 79161928
Diarrhoea 24.92 9.71 5852 574303 874637 78289596
Abortion late 24.90 9.71 12 580143 68 79164165
Temperature regulation disorder 24.83 9.71 6 580149 5847 79158386
Gamma-glutamyltransferase increased 24.77 9.71 266 579889 54414 79109819
Haemoptysis 24.73 9.71 274 579881 55725 79108508
Haemophagocytic lymphohistiocytosis 24.68 9.71 79 580076 21758 79142475
Potentiating drug interaction 24.58 9.71 17 580138 8802 79155431
Stress cardiomyopathy 24.50 9.71 27 580128 11139 79153094
Hepatotoxicity 24.40 9.71 247 579908 51105 79113128
Drug tolerance decreased 24.40 9.71 170 579985 12808 79151425
Poor venous access 24.36 9.71 220 579935 17929 79146304
Immunosuppression 24.24 9.71 168 579987 12635 79151598
Asthma 24.23 9.71 773 579382 134322 79029911
Dizziness 24.19 9.71 3409 576746 523032 78641201
Bradyphrenia 24.16 9.71 25 580130 10615 79153618
Asthenia 24.15 9.71 3308 576847 508381 78655852
Therapy partial responder 24.10 9.71 57 580098 17340 79146893
Leukopenia 24.06 9.71 654 579501 115859 79048374
Hallucination, auditory 24.00 9.71 74 580081 20619 79143614
COVID-19 23.96 9.71 921 579234 156753 79007480
Dislocation of vertebra 23.80 9.71 117 580038 7763 79156470
Osteonecrosis of jaw 23.52 9.71 201 579954 43025 79121208
Immunodeficiency 23.43 9.71 252 579903 21516 79142717
Melaena 23.43 9.71 307 579848 60583 79103650
Ultrasound antenatal screen 23.35 9.71 27 580128 666 79163567
Lip swelling 23.27 9.71 188 579967 40723 79123510
Obesity 23.24 9.71 372 579783 34753 79129480
Multiple-drug resistance 23.23 9.71 18 580137 8790 79155443
Fracture delayed union 23.22 9.71 49 580106 2061 79162172
Hyperlactacidaemia 23.22 9.71 6 580149 5589 79158644
Pulmonary tuberculosis 23.20 9.71 116 580039 7749 79156484
Flushing 23.07 9.71 478 579677 87790 79076443
Venoocclusive disease 23.05 9.71 3 580152 4570 79159663
Loose body in joint 23.04 9.71 37 580118 1258 79162975
Aphasia 22.95 9.71 223 579932 46509 79117724
Diabetes insipidus 22.95 9.71 5 580150 5232 79159001
Synovial disorder 22.94 9.71 47 580108 1936 79162297
Metastases to liver 22.82 9.71 117 580038 28197 79136036
Aphthous ulcer 22.81 9.71 205 579950 16684 79147549
Acute generalised exanthematous pustulosis 22.75 9.71 58 580097 17196 79147037
Tardive dyskinesia 22.71 9.71 26 580129 10545 79153688
Pulmonary alveolar haemorrhage 22.70 9.71 30 580125 11427 79152806
Pseudomonas infection 22.68 9.71 77 580078 20826 79143407
Cyanosis 22.67 9.71 100 580055 25082 79139151
Polyhydramnios 22.59 9.71 43 580112 1677 79162556
Haematocrit decreased 22.51 9.71 595 579560 60717 79103516
Pruritus genital 22.48 9.71 3 580152 4483 79159750
Blood alkaline phosphatase increased 22.35 9.71 327 579828 63337 79100896
Abortion threatened 22.32 9.71 21 580134 404 79163829
Influenza 22.28 9.71 1155 579000 128451 79035782
Oral herpes 22.19 9.71 301 579854 27153 79137080
Jaundice 22.01 9.71 265 579890 53084 79111149
Electrocardiogram QRS complex prolonged 21.84 9.71 28 580127 10805 79153428
Haemodynamic instability 21.73 9.71 60 580095 17322 79146911
Foetal distress syndrome 21.53 9.71 22 580133 470 79163763
Rebound effect 21.41 9.71 13 580142 7213 79157020
Weight decreased 21.41 9.71 2923 577232 352275 78811958
Palpitations 21.39 9.71 730 579425 125880 79038353
Placental disorder 21.37 9.71 30 580125 903 79163330
Breast cancer stage I 21.37 9.71 11 580144 6689 79157544
Endophthalmitis 21.34 9.71 10 580145 6418 79157815
Pulmonary arterial hypertension 21.31 9.71 120 580035 28246 79135987
Liver injury 21.24 9.71 551 579604 56063 79108170
Foetal death 21.21 9.71 115 580040 7929 79156304
Procedural pain 21.19 9.71 91 580064 22993 79141240
Product administration error 21.17 9.71 140 580015 31706 79132527
Pancreatitis 21.12 9.71 361 579794 68214 79096019
Hepatitis B reactivation 21.07 9.71 9 580146 6099 79158134
Hyperammonaemia 21.02 9.71 30 580125 11063 79153170
Trisomy 18 20.98 9.71 24 580131 585 79163648
Nephropathy toxic 20.96 9.71 77 580078 20342 79143891
Depression 20.87 9.71 1328 578827 215462 78948771
Graft versus host disease in skin 20.86 9.71 9 580146 6064 79158169
Myocardial ischaemia 20.82 9.71 105 580050 25414 79138819
Joint noise 20.81 9.71 70 580085 3904 79160329
Pulmonary congestion 20.71 9.71 114 580041 26986 79137247
Fluid retention 20.70 9.71 370 579785 69439 79094794
Accidental overdose 20.67 9.71 186 579969 39395 79124838
Oliguria 20.61 9.71 56 580099 16253 79147980
Pulmonary haemorrhage 20.56 9.71 48 580107 14669 79149564
Respiratory disorder neonatal 20.56 9.71 10 580145 58 79164175
Sinus bradycardia 20.53 9.71 104 580051 25143 79139090
Finger deformity 20.49 9.71 108 580047 7366 79156867
Cardiac failure acute 20.35 9.71 70 580085 18859 79145374
Cytomegalovirus infection reactivation 20.33 9.71 20 580135 8696 79155537
Peripheral sensory neuropathy 20.30 9.71 40 580115 12993 79151240
Lower limb fracture 20.21 9.71 258 579897 22957 79141276
Post procedural infection 20.17 9.71 147 580008 11237 79152996
Polyuria 20.16 9.71 50 580105 14964 79149269
Injection site warmth 20.14 9.71 180 579975 14627 79149606
Hemiparesis 20.13 9.71 153 580002 33580 79130653
Metastases to central nervous system 20.12 9.71 57 580098 16318 79147915
Mental disorder 20.11 9.71 139 580016 31163 79133070
Compartment syndrome 20.06 9.71 6 580149 5076 79159157
Respiratory disorder 20.00 9.71 219 579936 44637 79119596
Dysphagia 19.99 9.71 707 579448 121429 79042804
Haemoglobin decreased 19.94 9.71 1876 578279 220243 78943990
Drug hypersensitivity 19.86 9.71 1888 578267 297028 78867205
Hypophosphataemia 19.85 9.71 76 580079 19837 79144396
Labelled drug-drug interaction medication error 19.69 9.71 119 580036 27531 79136702
Feeling abnormal 19.59 9.71 952 579203 158247 79005986
Breast feeding 19.53 9.71 25 580130 687 79163546
Atrioventricular block 19.45 9.71 46 580109 13995 79150238
Haemorrhage in pregnancy 19.38 9.71 36 580119 1378 79162855
Stillbirth 19.26 9.71 68 580087 3887 79160346
Folate deficiency 19.23 9.71 61 580094 3299 79160934
Pulseless electrical activity 19.14 9.71 47 580108 14113 79150120
Human antichimeric antibody positive 19.11 9.71 39 580116 1602 79162631
Rhinorrhoea 19.10 9.71 705 579450 75369 79088864
Obstructive airways disorder 19.10 9.71 142 580013 31317 79132916
Cytomegalovirus chorioretinitis 19.08 9.71 8 580147 5482 79158751
Accidental death 19 9.71 4 580151 4287 79159946
Paranoia 18.83 9.71 75 580080 19357 79144876
Ingrown hair 18.75 9.71 25 580130 716 79163517
Transplant dysfunction 18.73 9.71 15 580140 7206 79157027
Pyrexia 18.70 9.71 4516 575639 674193 78490040
Autoimmune disorder 18.67 9.71 194 579961 16418 79147815
Respiratory acidosis 18.66 9.71 33 580122 11167 79153066
Renal injury 18.60 9.71 62 580093 16865 79147368
Bacteraemia 18.60 9.71 151 580004 32673 79131560
Ileus 18.57 9.71 113 580042 26098 79138135
Heparin-induced thrombocytopenia 18.53 9.71 26 580129 9656 79154577
Dysmorphism 18.52 9.71 22 580133 559 79163674
Acute myeloid leukaemia 18.47 9.71 140 580015 30745 79133488
Induced labour 18.45 9.71 27 580128 845 79163388
Hyperthyroidism 18.34 9.71 91 580064 22118 79142115
Blood lactic acid increased 18.26 9.71 41 580114 12703 79151530
Hepatic cirrhosis 18.21 9.71 356 579799 34550 79129683
Oesophageal carcinoma 18.16 9.71 33 580122 11051 79153182
Subdural haematoma 18.09 9.71 144 580011 31290 79132943
Device expulsion 18.05 9.71 112 580043 25749 79138484
Lower respiratory tract congestion 18.00 9.71 67 580088 3930 79160303
Coordination abnormal 17.96 9.71 65 580090 17247 79146986
Pleuritic pain 17.93 9.71 131 580024 10021 79154212
Pulmonary hypertension 17.92 9.71 244 579911 47836 79116397
Bladder cancer 17.90 9.71 77 580078 19449 79144784
Pulmonary embolism 17.83 9.71 1044 579111 170610 78993623
Bradypnoea 17.77 9.71 11 580144 6041 79158192
Febrile bone marrow aplasia 17.77 9.71 43 580112 12977 79151256
Ventricular arrhythmia 17.66 9.71 23 580132 8817 79155416
Multiple drug therapy 17.65 9.71 4 580151 4074 79160159
Hyperprolactinaemia 17.61 9.71 6 580149 4670 79159563
Dactylitis 17.60 9.71 52 580103 2705 79161528
Decreased appetite 17.54 9.71 2202 577953 340216 78824017
Cardiac failure chronic 17.49 9.71 34 580121 11101 79153132
Red blood cell count decreased 17.48 9.71 545 579610 56968 79107265
Ankle arthroplasty 17.47 9.71 36 580119 1489 79162744
Anal fistula 17.46 9.71 98 580057 6846 79157387
Cross sensitivity reaction 17.41 9.71 3 580152 3709 79160524
Body height below normal 17.41 9.71 43 580112 2010 79162223
Acute graft versus host disease in skin 17.38 9.71 18 580137 7640 79156593
International normalised ratio increased 17.37 9.71 476 579679 84245 79079988
Gastric haemorrhage 17.32 9.71 54 580101 14996 79149237
Erectile dysfunction 17.32 9.71 52 580103 14612 79149621
Tubulointerstitial nephritis 17.31 9.71 186 579969 38049 79126184
Cushingoid 17.30 9.71 124 580031 9428 79154805
Low birth weight baby 17.29 9.71 22 580133 601 79163632
Maternal exposure during breast feeding 17.27 9.71 52 580103 2733 79161500
Delusion 17.26 9.71 83 580072 20340 79143893
Acute coronary syndrome 17.21 9.71 87 580068 21046 79143187
Hyperbilirubinaemia 17.21 9.71 106 580049 24412 79139821
Placental insufficiency 17.19 9.71 30 580125 1093 79163140
Speech disorder developmental 17.19 9.71 23 580132 661 79163572
Device leakage 17.18 9.71 33 580122 10823 79153410
Lethargy 17.12 9.71 455 579700 80837 79083396
Device related infection 17.11 9.71 163 579992 34131 79130102
Alcohol interaction 17.10 9.71 7 580148 4867 79159366
Nightmare 17.03 9.71 114 580041 25747 79138486
Anal fissure 16.97 9.71 105 580050 7598 79156635
End stage renal disease 16.96 9.71 40 580115 12180 79152053
Toxic skin eruption 16.92 9.71 94 580061 22199 79142034
Pain in jaw 16.92 9.71 235 579920 45916 79118317
Oligohydramnios 16.90 9.71 59 580096 3353 79160880
Respiration abnormal 16.90 9.71 19 580136 7769 79156464
Urinary retention 16.84 9.71 300 579855 56330 79107903
Anaemia macrocytic 16.83 9.71 83 580072 5514 79158719
Right ventricular failure 16.80 9.71 101 580054 23396 79140837
Foetal anticonvulsant syndrome 16.79 9.71 14 580141 228 79164005
Anger 16.78 9.71 66 580089 17096 79147137
Depressed mood 16.67 9.71 250 579905 48230 79116003
Sleep disorder due to a general medical condition 16.59 9.71 51 580104 14226 79150007
Strongyloidiasis 16.53 9.71 4 580151 3894 79160339
Fine motor skill dysfunction 16.51 9.71 80 580075 5277 79158956
Drug screen positive 16.49 9.71 12 580143 6051 79158182
Virologic failure 16.45 9.71 5 580150 4186 79160047
Jaundice cholestatic 16.42 9.71 36 580119 11248 79152985
Colitis ulcerative 16.37 9.71 349 579806 34393 79129840
Short stature 16.34 9.71 23 580132 694 79163539
Sleep terror 16.31 9.71 6 580149 4452 79159781
Renal disorder 16.30 9.71 212 579943 41893 79122340
Myocarditis 16.30 9.71 92 580063 21641 79142592
Hyperlipidaemia 16.21 9.71 117 580038 25976 79138257
Sickle cell anaemia 16.18 9.71 22 580133 642 79163591
Hepatic encephalopathy 16.18 9.71 106 580049 24060 79140173
Anhedonia 16.08 9.71 55 580100 14843 79149390
Cardiomyopathy 16.01 9.71 133 580022 28641 79135592
Acute myocardial infarction 16.01 9.71 432 579723 76604 79087629
Hyperthermia 16.01 9.71 72 580083 17965 79146268
Type 1 diabetes mellitus 16 9.71 16 580139 6903 79157330
Onychomycosis 15.99 9.71 109 580046 8152 79156081
Hypoxic-ischaemic encephalopathy 15.99 9.71 20 580135 7800 79156433
Spinal osteoarthritis 15.98 9.71 191 579964 16736 79147497
Drug tolerance 15.93 9.71 113 580042 8562 79155671
Atrial tachycardia 15.92 9.71 17 580138 7116 79157117
Hypernatraemia 15.83 9.71 53 580102 14398 79149835
Foot operation 15.83 9.71 83 580072 5650 79158583
Panic attack 15.82 9.71 107 580048 24109 79140124
Hypertransaminasaemia 15.79 9.71 40 580115 11884 79152349
Incorrect route of product administration 15.78 9.71 170 579985 34759 79129474
Oxygen saturation decreased 15.78 9.71 1116 579039 127931 79036302
Hypomania 15.73 9.71 19 580136 7525 79156708
Dysgeusia 15.73 9.71 307 579848 56870 79107363
Haematoma 15.68 9.71 276 579879 51919 79112314
Personality disorder 15.66 9.71 13 580142 6133 79158100
Polyneuropathy 15.64 9.71 107 580048 24044 79140189
Abortion missed 15.54 9.71 31 580124 1252 79162981
Oesophageal fibrosis 15.54 9.71 12 580143 174 79164059
Pharyngitis streptococcal 15.48 9.71 132 580023 10582 79153651
Bronchioloalveolar carcinoma 15.46 9.71 8 580147 54 79164179
Dyslipidaemia 15.42 9.71 39 580116 11594 79152639
Paralysis 15.37 9.71 47 580108 13130 79151103
Immune effector cell-associated neurotoxicity syndrome 15.36 9.71 12 580143 5836 79158397
Antibody test positive 15.35 9.71 50 580105 2742 79161491
Postoperative wound infection 15.35 9.71 153 580002 12808 79151425
Schizophrenia 15.34 9.71 59 580096 15381 79148852
Skin necrosis 15.32 9.71 200 579955 17887 79146346
Acute myeloid leukaemia recurrent 15.30 9.71 3 580152 3380 79160853
Affective disorder 15.27 9.71 23 580132 8296 79155937
Tuberculin test positive 15.25 9.71 57 580098 3351 79160882
Face oedema 15.23 9.71 131 580024 28005 79136228
Bronchial carcinoma 15.21 9.71 30 580125 1202 79163031
Hypercapnia 15.18 9.71 26 580129 8909 79155324
Bone pain 15.12 9.71 300 579855 55442 79108791
Cellulitis 15.09 9.71 953 579202 108107 79056126
Left ventricular dysfunction 15.04 9.71 81 580074 19280 79144953
Glomerular filtration rate decreased 14.99 9.71 100 580055 22602 79141631
Hepatic cancer 14.99 9.71 34 580121 10495 79153738
Drug dose omission by device 14.98 9.71 14 580141 6236 79157997
Endodontic procedure 14.97 9.71 49 580106 2694 79161539
Drug abuser 14.97 9.71 13 580142 6000 79158233
Radiation inflammation 14.94 9.71 25 580130 880 79163353
Pemphigoid 14.91 9.71 59 580096 15256 79148977
Lung disorder 14.90 9.71 723 579432 79834 79084399
C-reactive protein decreased 14.87 9.71 48 580107 2620 79161613
Pleural effusion 14.82 9.71 885 579270 144377 79019856
Skin exfoliation 14.81 9.71 297 579858 54803 79109430
Injection site haemorrhage 14.80 9.71 285 579870 27585 79136648
Anticholinergic syndrome 14.74 9.71 4 580151 3607 79160626
Nasal polyps 14.71 9.71 19 580136 7308 79156925
Metastases to lung 14.66 9.71 75 580080 18088 79146145
Disturbance in social behaviour 14.64 9.71 9 580146 4961 79159272
Toothache 14.56 9.71 215 579940 19755 79144478
Intestinal stenosis 14.54 9.71 60 580095 3694 79160539
Amylase increased 14.53 9.71 38 580117 11171 79153062
Injection site urticaria 14.52 9.71 150 580005 12676 79151557
B-cell lymphoma 14.51 9.71 86 580069 6129 79158104
Progressive multifocal leukoencephalopathy 14.49 9.71 89 580066 20511 79143722
Muscle spasticity 14.48 9.71 94 580061 21381 79142852
Joint lock 14.48 9.71 54 580101 3171 79161062
Polydipsia 14.46 9.71 16 580139 6589 79157644
COVID-19 pneumonia 14.45 9.71 137 580018 28712 79135521
Hepatitis fulminant 14.40 9.71 19 580136 7243 79156990
Arthritis bacterial 14.36 9.71 115 580040 9051 79155182
Knee operation 14.23 9.71 82 580073 5784 79158449
Hypoventilation 14.23 9.71 19 580136 7205 79157028
Injury 14.22 9.71 695 579460 76801 79087432
Eosinophil count increased 14.17 9.71 70 580085 17035 79147198
Lacrimal disorder 14.17 9.71 18 580137 491 79163742
Diaphragmatic disorder 14.15 9.71 36 580119 1714 79162519
Alcohol abuse 14.09 9.71 11 580144 5352 79158881
Angina unstable 14.06 9.71 67 580088 16460 79147773
Osteochondrosis 14.05 9.71 39 580116 1957 79162276
Clear cell renal cell carcinoma 14.05 9.71 46 580109 2530 79161703
Coronary artery bypass 14.04 9.71 14 580141 6048 79158185
Prescribed overdose 14.01 9.71 368 579787 37515 79126718
Lymph gland infection 13.99 9.71 19 580136 554 79163679
Acute respiratory failure 13.96 9.71 328 579827 59213 79105020
Coronary arterial stent insertion 13.95 9.71 14 580141 6030 79158203
Dry skin 13.95 9.71 382 579773 67613 79096620
Ischaemic stroke 13.89 9.71 164 579991 32967 79131266
Cyst 13.88 9.71 158 579997 13682 79150551
Hepatitis acute 13.82 9.71 62 580093 15480 79148753
Hyperuricaemia 13.82 9.71 42 580113 11757 79152476
Twin pregnancy 13.80 9.71 24 580131 872 79163361
Musculoskeletal disorder 13.76 9.71 226 579929 21222 79143011
Epstein-Barr virus infection 13.74 9.71 56 580099 14360 79149873
Salivary hypersecretion 13.72 9.71 55 580100 14169 79150064
Anti-neutrophil cytoplasmic antibody positive vasculitis 13.67 9.71 5 580150 3724 79160509
Parkinsonism 13.66 9.71 68 580087 16516 79147717
Metastasis 13.65 9.71 18 580137 6862 79157371
Laryngospasm 13.61 9.71 6 580149 3991 79160242
Palmoplantar keratoderma 13.60 9.71 5 580150 3711 79160522
Mitochondrial toxicity 13.59 9.71 3 580152 3111 79161122
Appendicitis 13.53 9.71 92 580063 20702 79143531
Acute lung injury 13.50 9.71 3 580152 3097 79161136
Hypospadias 13.49 9.71 10 580145 136 79164097
Diabetes mellitus 13.47 9.71 451 579704 77939 79086294
Enterocolitis 13.45 9.71 57 580098 14455 79149778
Blood folate increased 13.43 9.71 18 580137 518 79163715
Invasive ductal breast carcinoma 13.41 9.71 81 580074 5811 79158422
Myopathy 13.37 9.71 91 580064 20472 79143761
Hypothyroidism 13.31 9.71 285 579870 52107 79112126
Acute lymphocytic leukaemia recurrent 13.31 9.71 9 580146 4715 79159518
Complications of transplanted kidney 13.31 9.71 16 580139 6350 79157883
Lipase increased 13.29 9.71 68 580087 16398 79147835
Hydrocephalus 13.28 9.71 28 580127 8872 79155361
Cholestasis of pregnancy 13.26 9.71 25 580130 968 79163265
Aspartate aminotransferase increased 13.21 9.71 850 579305 137791 79026442
Surgery 13.21 9.71 322 579833 32444 79131789
Chronic graft versus host disease 13.19 9.71 18 580137 6763 79157470
Rash pruritic 13.06 9.71 642 579513 70987 79093246
Hemiplegia 13.04 9.71 60 580095 14879 79149354
Lymphatic fistula 13.01 9.71 22 580133 781 79163452
Motor developmental delay 13.01 9.71 12 580143 225 79164008
Ligament rupture 12.95 9.71 54 580101 3340 79160893
Pulmonary function test abnormal 12.93 9.71 7 580148 4137 79160096
Eosinophilia 12.92 9.71 242 579913 45103 79119130
Joint ankylosis 12.86 9.71 40 580115 2140 79162093
Hypocalcaemia 12.85 9.71 271 579884 49653 79114580
Osteoporotic fracture 12.84 9.71 63 580092 4177 79160056
Heart rate irregular 12.83 9.71 320 579835 32359 79131874
Tooth abscess 12.81 9.71 177 579978 16033 79148200
Peritoneal dialysis complication 12.80 9.71 42 580113 2312 79161921
Inadequate analgesia 12.80 9.71 9 580146 4620 79159613
Reticulocyte count increased 12.79 9.71 30 580125 1356 79162877
Personality change 12.79 9.71 35 580120 10135 79154098
Amniotic fluid volume increased 12.78 9.71 10 580145 148 79164085
Subarachnoid haemorrhage 12.76 9.71 115 580040 24350 79139883
Wound infection pseudomonas 12.75 9.71 33 580122 1588 79162645
Breast abscess 12.74 9.71 31 580124 1435 79162798
Mycobacterium tuberculosis complex test positive 12.74 9.71 47 580108 2745 79161488
Threatened labour 12.74 9.71 19 580136 605 79163628
Joint warmth 12.71 9.71 33 580122 1591 79162642
Bronchial secretion retention 12.70 9.71 7 580148 4097 79160136
Atrioventricular block complete 12.63 9.71 70 580085 16540 79147693
Generalised tonic-clonic seizure 12.62 9.71 234 579921 43676 79120557
Foetal growth restriction 12.61 9.71 39 580116 2080 79162153
Septic shock 12.55 9.71 748 579407 122053 79042180
Hypercholesterolaemia 12.55 9.71 237 579918 22858 79141375
Euglycaemic diabetic ketoacidosis 12.49 9.71 19 580136 6825 79157408
Defaecation disorder 12.43 9.71 20 580135 681 79163552
Frequent bowel movements 12.43 9.71 292 579863 29247 79134986
Ketoacidosis 12.32 9.71 24 580131 7830 79156403
Femoral hernia incarcerated 12.25 9.71 22 580133 820 79163413
Haematemesis 12.23 9.71 288 579867 51976 79112257
Capillary fragility 12.20 9.71 11 580144 200 79164033
Chronic sinusitis 12.17 9.71 51 580104 12975 79151258
Cervical incompetence 12.15 9.71 17 580138 510 79163723
Prostatic specific antigen increased 12.14 9.71 37 580118 10349 79153884
Colitis microscopic 12.14 9.71 39 580116 10729 79153504
Chest pain 12.14 9.71 1835 578320 280469 78883764
Postpartum haemorrhage 12.07 9.71 32 580123 1563 79162670
Agranulocytosis 12.02 9.71 243 579912 44787 79119446
Renal cancer 11.97 9.71 47 580108 12179 79152054
Metabolic disorder 11.96 9.71 31 580124 9139 79155094
Oligoarthritis 11.95 9.71 20 580135 704 79163529
Pneumothorax 11.95 9.71 140 580015 28183 79136050
Psychiatric decompensation 11.92 9.71 7 580148 3956 79160277
Bone density abnormal 11.92 9.71 49 580106 3011 79161222
Prescribed underdose 11.88 9.71 290 579865 29224 79135009
Swollen tongue 11.88 9.71 228 579927 42342 79121891
Injection site extravasation 11.87 9.71 115 580040 9554 79154679
Human anti-human antibody test 11.84 9.71 15 580140 408 79163825
Pneumonia aspiration 11.80 9.71 384 579771 66583 79097650
Infusion site pain 11.75 9.71 58 580097 14118 79150115
Intracranial pressure increased 11.74 9.71 27 580128 8295 79155938
Multiple allergies 11.71 9.71 38 580117 10422 79153811
Skin toxicity 11.71 9.71 27 580128 8287 79155946
Pancreatitis acute 11.70 9.71 273 579882 49331 79114902
C-reactive protein 11.69 9.71 69 580086 4910 79159323
Myofascial pain syndrome 11.67 9.71 37 580118 2000 79162233
Purging 11.65 9.71 6 580149 40 79164193
Prothrombin consumption time prolonged 11.65 9.71 6 580149 40 79164193
Incoherent 11.64 9.71 24 580131 7668 79156565
Cyst rupture 11.64 9.71 19 580136 655 79163578
Walking aid user 11.64 9.71 119 580036 10029 79154204
Accessory spleen 11.64 9.71 11 580144 213 79164020
Dermatitis atopic 11.63 9.71 36 580119 10020 79154213
Alanine aminotransferase increased 11.62 9.71 1021 579134 161549 79002684
Gestational hypertension 11.58 9.71 35 580120 1844 79162389
Hepatitis C 11.57 9.71 46 580109 11879 79152354
Diverticular perforation 11.56 9.71 78 580077 5815 79158418
Intervertebral disc degeneration 11.53 9.71 170 579985 15615 79148618
Complication of device removal 11.52 9.71 7 580148 3882 79160351
Hypertelorism 11.52 9.71 9 580146 133 79164100
Candida infection 11.50 9.71 202 579953 38012 79126221
Axonal neuropathy 11.49 9.71 37 580118 2017 79162216
Ileus paralytic 11.44 9.71 34 580121 9586 79154647
Abortion incomplete 11.42 9.71 4 580151 3060 79161173
Insomnia 11.41 9.71 1586 578569 243584 78920649
Long QT syndrome 11.39 9.71 16 580139 5939 79158294
Roseola 11.39 9.71 4 580151 8 79164225
Hand fracture 11.38 9.71 81 580074 6144 79158089
Metastases to meninges 11.36 9.71 6 580149 3595 79160638
Lip blister 11.33 9.71 45 580110 2722 79161511
Blood phosphorus increased 11.30 9.71 38 580117 10309 79153924
Toxoplasma serology positive 11.30 9.71 6 580149 43 79164190
Vertigo 11.27 9.71 400 579755 68682 79095551
Nail injury 11.25 9.71 18 580137 610 79163623
Bacterial sepsis 11.25 9.71 27 580128 8171 79156062
Tooth disorder 11.25 9.71 260 579895 25973 79138260
Complication of device insertion 11.23 9.71 18 580137 6332 79157901
Dry eye 11.23 9.71 350 579805 36581 79127652
Sensitisation 11.23 9.71 5 580150 3306 79160927
Chondropathy 11.23 9.71 42 580113 2470 79161763
Paraesthesia oral 11.22 9.71 95 580060 20376 79143857
Pelvic fracture 11.21 9.71 137 580018 12067 79152166
Hepatocellular injury 11.21 9.71 262 579893 47331 79116902
Tetany 11.18 9.71 3 580152 2725 79161508
Abdominal distension 11.15 9.71 735 579420 118915 79045318
Failed induction of labour 11.14 9.71 12 580143 273 79163960
Catatonia 11.11 9.71 30 580125 8726 79155507
Anal prolapse 11.07 9.71 7 580148 72 79164161
Lymphopenia 11.06 9.71 156 579999 30401 79133832
Arthropod bite 11.02 9.71 102 580053 8369 79155864
Acute graft versus host disease in intestine 10.99 9.71 8 580147 4033 79160200
Drug specific antibody 10.97 9.71 43 580112 2585 79161648
Kidney transplant rejection 10.94 9.71 38 580117 10208 79154025
Hyperhomocysteinaemia 10.93 9.71 16 580139 501 79163732
Dyspnoea at rest 10.87 9.71 23 580132 7279 79156954
Tooth infection 10.84 9.71 195 579960 18637 79145596
Genital haemorrhage 10.81 9.71 18 580137 6237 79157996
Pancreatic steatosis 10.81 9.71 25 580130 1120 79163113
Acute pulmonary oedema 10.80 9.71 60 580095 14170 79150063
Congenital umbilical hernia 10.78 9.71 4 580151 10 79164223
Iritis 10.77 9.71 56 580099 3799 79160434
Oculogyric crisis 10.75 9.71 4 580151 2948 79161285
Device occlusion 10.75 9.71 47 580108 11819 79152414
Cholangitis 10.75 9.71 52 580103 12724 79151509
Hypogammaglobulinaemia 10.73 9.71 53 580102 12898 79151335
Cartilage injury 10.72 9.71 30 580125 1513 79162720
Human herpesvirus 6 infection 10.70 9.71 14 580141 5356 79158877
Spinal disorder 10.69 9.71 118 580037 10142 79154091
Iodine allergy 10.67 9.71 17 580138 574 79163659
Onychomadesis 10.65 9.71 70 580085 5172 79159061
Persecutory delusion 10.63 9.71 12 580143 4897 79159336
Accidental exposure to product by child 10.60 9.71 4 580151 2922 79161311
Benign ovarian tumour 10.59 9.71 13 580142 342 79163891
Blood glucose decreased 10.56 9.71 131 580024 26103 79138130
Toxic encephalopathy 10.56 9.71 45 580110 11395 79152838
Blood urea increased 10.56 9.71 272 579883 48518 79115715
Upper respiratory tract infection 10.56 9.71 785 579370 90383 79073850
Large intestinal stenosis 10.55 9.71 45 580110 2811 79161422
Ventricular extrasystoles 10.55 9.71 92 580063 19612 79144621
Product administered to patient of inappropriate age 10.54 9.71 15 580140 5538 79158695
Respiratory tract infection 10.53 9.71 444 579711 48245 79115988
Osteopenia 10.52 9.71 190 579965 18174 79146059
Nasal oedema 10.52 9.71 32 580123 1692 79162541
Corneal oedema 10.51 9.71 3 580152 2617 79161616
Post-traumatic stress disorder 10.49 9.71 12 580143 4869 79159364
Neurologic neglect syndrome 10.49 9.71 4 580151 2903 79161330
Rash erythematous 10.48 9.71 330 579825 57439 79106794
Hepatic cyst 10.43 9.71 78 580077 6011 79158222
Tonsillitis 10.39 9.71 84 580071 6630 79157603
Capillary leak syndrome 10.38 9.71 8 580147 3917 79160316
Diplopia 10.36 9.71 176 579979 33290 79130943
Anaemia folate deficiency 10.35 9.71 12 580143 297 79163936
Mesothelioma 10.33 9.71 13 580142 351 79163882
Pharyngitis 10.29 9.71 224 579931 22151 79142082
Tumour haemorrhage 10.27 9.71 9 580146 4135 79160098
Rash maculo-papular 10.26 9.71 320 579835 55758 79108475
Pyelonephritis acute 10.23 9.71 77 580078 5946 79158287
Serum ferritin increased 10.14 9.71 113 580042 9734 79154499
Spondylitis 10.12 9.71 64 580091 4667 79159566
Nervous system disorder 10.11 9.71 136 580019 26720 79137513
Eating disorder 10.06 9.71 99 580056 20598 79143635
Abdominal adhesions 10.05 9.71 52 580103 3521 79160712
Skin laceration 10.04 9.71 279 579876 28683 79135550
Lung transplant 10.04 9.71 11 580144 4550 79159683
Vanishing twin syndrome 10.03 9.71 7 580148 86 79164147
Renal tubular acidosis 10.03 9.71 7 580148 3607 79160626
Vascular rupture 10.02 9.71 31 580124 1654 79162579
Rales 10.01 9.71 95 580060 19906 79144327
Bone density increased 10.01 9.71 20 580135 809 79163424
Skin neoplasm excision 9.99 9.71 23 580132 1027 79163206
Respiratory tract infection viral 9.98 9.71 59 580096 4200 79160033
Hepatitis E antibody positive 9.98 9.71 11 580144 257 79163976
Pupillary reflex impaired 9.98 9.71 6 580149 3347 79160886
Vacuum extractor delivery 9.97 9.71 8 580147 123 79164110
Breast cancer 9.97 9.71 319 579836 33462 79130771
Abortion induced 9.97 9.71 87 580068 7022 79157211
Skin ulcer haemorrhage 9.96 9.71 16 580139 544 79163689
Cogwheel rigidity 9.95 9.71 5 580150 3083 79161150
Congestive cardiomyopathy 9.88 9.71 48 580107 11732 79152501
Bradykinesia 9.88 9.71 28 580127 8015 79156218
Pulmonary pain 9.87 9.71 61 580094 4412 79159821
Head injury 9.87 9.71 202 579953 37167 79127066
Gastrooesophageal sphincter insufficiency 9.85 9.71 10 580145 212 79164021
Hospitalisation 9.81 9.71 573 579582 93663 79070570
Visual acuity reduced 9.78 9.71 153 580002 29316 79134917
Reversible cerebral vasoconstriction syndrome 9.78 9.71 5 580150 3052 79161181
Squamous cell carcinoma of lung 9.77 9.71 38 580117 2276 79161957
Urine ketone body present 9.77 9.71 7 580148 3558 79160675
Carotid artery thrombosis 9.76 9.71 5 580150 3048 79161185
Vascular device infection 9.75 9.71 40 580115 10236 79153997
Tumour marker increased 9.74 9.71 10 580145 4262 79159971
Cervix haematoma uterine 9.73 9.71 3 580152 3 79164230
Coloboma 9.73 9.71 3 580152 3 79164230
Product preparation error 9.71 9.71 17 580138 5776 79158457

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Small for dates baby 17.38 16.49 150 2722 2659 84261

Pharmacologic Action:

SourceCodeDescription
ATC B03AD01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
ATC B03AD02 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
ATC B03AD03 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
ATC B03AD04 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
ATC B03AD05 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE02 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03BB01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Folic acid and derivatives
ATC B03BB51 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Folic acid and derivatives
ATC V04CX02 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Other diagnostic agents
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Vitamin deficiency indication 85670002
Iron deficiency anemia indication 87522002
Mineral deficiency indication 111379007
Folic acid deficiency indication 190633005
Pregnancy, function indication 289908002
Breastfeeding (mother) indication 413712001
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Prevention of Vitamin B12 Deficiency indication
Homocystinuria off-label use 11282001 DOID:9263
Homocystinemia off-label use 52311001
Prevention of Fetal Neural Tube Defects during Pregnancy off-label use
Peptic ulcer contraindication 13200003 DOID:750
Bipolar disorder contraindication 13746004 DOID:3312
Constipation contraindication 14760008 DOID:2089
Operation on stomach contraindication 16453004
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hemosiderosis contraindication 39011001 DOID:12119
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Diabetes mellitus contraindication 73211009 DOID:9351
Phototoxicity contraindication 84326006
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Osteolysis contraindication 203522001
Hypomania contraindication 231496004
Esophageal dysmotility contraindication 266434009 DOID:9192
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.46 acidic
pKa2 5.15 acidic
pKa3 12.96 acidic
pKa4 4.55 Basic
pKa5 4.15 Basic
pKa6 2.28 Basic
pKa7 1.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thymidylate synthase Enzyme Ki 4.40 CHEMBL
Aldose reductase Enzyme IC50 4.28 CHEMBL
Dihydrofolate reductase Enzyme Kd 6.09 CHEMBL
Dihydrofolate reductase Enzyme Kd 6.09 CHEMBL

External reference:

IDSource
4017507 VUID
N0000145892 NUI
D00070 KEGG_DRUG
6484-89-5 SECONDARY_CAS_RN
4017507 VANDF
C0016410 UMLSCUI
CHEBI:27470 CHEBI
FA PDB_CHEM_ID
CHEMBL1622 ChEMBL_ID
CHEMBL2107429 ChEMBL_ID
D005492 MESH_DESCRIPTOR_UI
DB00158 DRUGBANK_ID
4563 IUPHAR_LIGAND_ID
68 INN_ID
935E97BOY8 UNII
135398658 PUBCHEM_CID
1300473 RXNORM
264 MMSL
4759 MMSL
d00241 MMSL
001049 NDDF
126224002 SNOMEDCT_US
6247001 SNOMEDCT_US
63718003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 1 mg ORAL unapproved drug other 17 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 1 mg ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 1 mg ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 1 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 1.40 mg ORAL unapproved drug other 15 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 1.40 mg ORAL unapproved drug other 15 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 1.40 mg ORAL unapproved drug other 15 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 1 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 1 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 1 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 1 mg ORAL Unapproved drug other 9 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 1 mg ORAL Unapproved drug other 11 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-7814 TABLET 1 mg ORAL ANDA 12 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-7814 TABLET 1 mg ORAL ANDA 12 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-8427 TABLET 1 mg ORAL ANDA 11 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1700 ug ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 0.40 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1 mg ORAL Unapproved drug other 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 680 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 680 ug ORAL UNAPPROVED DRUG OTHER 13 sections