folic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1231 59-30-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • folic acid
  • acifolic
  • aspol
  • cytofol
  • folacid
  • pteroylglutamic acid
  • folate sodium
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
  • Molecular weight: 441.40
  • Formula: C19H19N7O6
  • CLOGP: -1.43
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 207.93
  • ALOGS: -3.74
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 mg O
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.43 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 75 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 9.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 52 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1946 FDA LEDERLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1680.41 10.10 3884 460498 153328 55674357
Rheumatoid arthritis 1592.21 10.10 6803 457579 375801 55451884
Systemic lupus erythematosus 1566.51 10.10 4111 460271 175967 55651718
Glossodynia 1385.63 10.10 3539 460843 148919 55678766
Hand deformity 1121.55 10.10 3024 461358 131468 55696217
Maternal exposure during pregnancy 1041.52 10.10 3684 460698 185869 55641816
Arthropathy 1019.71 10.10 3797 460585 196478 55631207
Alopecia 954.30 10.10 4860 459522 288598 55539087
Wound 932.05 10.10 2888 461494 135916 55691769
Abdominal discomfort 931.02 10.10 4634 459748 272640 55555045
Completed suicide 842.13 10.10 70 464312 133763 55693922
Synovitis 743.27 10.10 2964 461418 158341 55669344
Pericarditis 733.36 10.10 2269 462113 106654 55721031
Anti-cyclic citrullinated peptide antibody positive 706.97 10.10 2100 462282 96500 55731185
Infusion related reaction 691.36 10.10 3479 460903 205452 55622233
Discomfort 689.58 10.10 2650 461732 139111 55688574
Contraindicated product administered 667.08 10.10 3173 461209 183113 55644572
Swelling 652.20 10.10 3784 460598 235987 55591698
Joint swelling 612.97 10.10 4290 460092 285510 55542175
Toxicity to various agents 597.26 10.10 583 463799 223981 55603704
Death 570.25 10.10 1230 463152 340196 55487489
Pain 519.78 10.10 8005 456377 655179 55172506
Product use issue 454.37 10.10 2856 461526 183185 55644500
Duodenal ulcer perforation 438.82 10.10 1401 462981 66941 55760744
Helicobacter infection 423.13 10.10 1449 462933 71819 55755866
Rheumatoid factor positive 422.01 10.10 1392 462990 67668 55760017
Exposure during pregnancy 408.04 10.10 2209 462173 134133 55693552
Hepatic enzyme increased 395.63 10.10 2594 461788 168790 55658895
Arthralgia 349.32 10.10 5942 458440 495727 55331958
Drug abuse 349.02 10.10 67 464315 67543 55760142
Intentional overdose 334.14 10.10 76 464306 68041 55759644
Therapeutic product effect decreased 291.85 10.10 2392 461990 167060 55660625
Musculoskeletal stiffness 287.10 10.10 2236 462146 153771 55673914
Drug intolerance 283.51 10.10 3385 460997 261433 55566252
Drug interaction 252.75 10.10 885 463497 208870 55618815
Treatment failure 251.05 10.10 2324 462058 168068 55659617
Febrile neutropenia 247.15 10.10 304 464078 105241 55722444
Hip arthroplasty 235.39 10.10 778 463604 37845 55789840
Knee arthroplasty 225.24 10.10 840 463542 43419 55784266
Suicide attempt 222.58 10.10 99 464283 57737 55769948
Psoriatic arthropathy 216.42 10.10 1192 463190 72816 55754869
Disease progression 209.41 10.10 340 464042 104833 55722852
Foetal exposure during pregnancy 205.83 10.10 681 463701 33142 55794543
Cardiac arrest 203.77 10.10 247 464135 86067 55741618
Malignant neoplasm progression 203.61 10.10 184 464198 73403 55754282
Depressed level of consciousness 202.83 10.10 106 464276 56327 55771358
Overdose 202.51 10.10 351 464031 105479 55722206
Gestational diabetes 197.69 10.10 286 464096 7778 55819907
Nausea 196.78 10.10 4805 459577 759373 55068312
Hypersensitivity 194.73 10.10 3083 461299 253325 55574360
Constipation 194.37 10.10 930 463452 201013 55626672
Diarrhoea 189.14 10.10 3927 460455 634580 55193105
Impaired healing 184.31 10.10 1288 463094 85553 55742132
Nasopharyngitis 179.30 10.10 2687 461695 218272 55609413
Rheumatic fever 177.73 10.10 583 463799 28244 55799441
Device expulsion 173.26 10.10 23 464359 30426 55797259
Acute kidney injury 168.35 10.10 1228 463154 239535 55588150
Red blood cell sedimentation rate abnormal 164.52 10.10 429 463953 18244 55809441
Anxiety 163.74 10.10 929 463453 192243 55635442
Sedation 161.00 10.10 44 464338 34810 55792875
Swollen joint count increased 159.91 10.10 501 463881 23683 55804002
Drug hypersensitivity 150.53 10.10 1497 462885 273708 55553977
Folliculitis 145.91 10.10 863 463519 54116 55773569
Muscle injury 142.50 10.10 829 463553 51671 55776014
Sickle cell anaemia with crisis 139.13 10.10 189 464193 4839 55822846
Tremor 136.45 10.10 525 463857 120564 55707121
Blister 135.34 10.10 1434 462948 107453 55720232
C-reactive protein abnormal 135.02 10.10 632 463750 36177 55791508
Sleep disorder due to general medical condition, insomnia type 134.77 10.10 710 463672 42628 55785057
Pregnancy 134.52 10.10 585 463797 32448 55795237
Small for dates baby 133.29 10.10 155 464227 3375 55824310
Bradycardia 132.68 10.10 220 464162 67284 55760401
Electrocardiogram QT prolonged 132.25 10.10 153 464229 54435 55773250
Neutropenia 132.20 10.10 764 463618 157403 55670282
Hypotension 130.64 10.10 1378 463004 249130 55578555
Somnolence 129.90 10.10 802 463580 162611 55665074
Agitation 129.46 10.10 163 464219 55873 55771812
Asthenia 126.40 10.10 2029 462353 340944 55486741
Dyspnoea 124.87 10.10 3831 460551 588746 55238939
Dizziness 124.80 10.10 2268 462114 373872 55453813
Neuropathy peripheral 123.21 10.10 435 463947 102458 55725227
Respiratory arrest 121.69 10.10 50 464332 30575 55797110
Lactic acidosis 118.94 10.10 72 464310 35274 55792411
Abortion spontaneous 116.87 10.10 688 463694 43065 55784620
Cardiac failure 114.49 10.10 324 464058 81769 55745916
Multiple sclerosis relapse 113.00 10.10 122 464260 44781 55782904
Hyperhidrosis 112.50 10.10 398 463984 93690 55733995
Irritable bowel syndrome 111.61 10.10 955 463427 67503 55760182
Lower respiratory tract infection 110.77 10.10 1440 462942 113354 55714331
Vomiting 109.81 10.10 3201 461181 495027 55332658
Rash 108.80 10.10 5039 459343 488008 55339677
Asthma 108.59 10.10 519 463863 112251 55715434
Renal failure 107.31 10.10 507 463875 109993 55717692
Live birth 103.84 10.10 377 464005 19228 55808457
Myalgia 103.32 10.10 651 463731 131374 55696311
Neoplasm progression 98.58 10.10 72 464310 31944 55795741
Rhabdomyolysis 98.44 10.10 114 464268 40544 55787141
Condition aggravated 98.17 10.10 3622 460760 341276 55486409
Intentional self-injury 97.38 10.10 42 464340 24950 55802735
Osteoarthritis 97.20 10.10 1052 463330 79244 55748441
Drug dependence 95.87 10.10 33 464349 22500 55805185
Arthritis 95.66 10.10 1251 463131 98601 55729084
Cardio-respiratory arrest 93.94 10.10 197 464185 55124 55772561
Syncope 91.24 10.10 521 463861 107678 55720007
Drug withdrawal syndrome 90.80 10.10 50 464332 25807 55801878
Tachycardia 90.26 10.10 508 463874 105368 55722317
Insomnia 90.24 10.10 1080 463302 190780 55636905
Hyponatraemia 89.85 10.10 485 463897 101654 55726031
Drug ineffective 89.34 10.10 8764 455618 910225 54917460
Cardiac failure congestive 86.03 10.10 401 463981 87319 55740366
Product quality issue 85.82 10.10 81 464301 31655 55796030
Hypoxia 85.71 10.10 199 464183 53698 55773987
Balance disorder 85.37 10.10 333 464049 76187 55751498
Depression 85.05 10.10 1013 463369 179104 55648581
Plasma cell myeloma 84.45 10.10 160 464222 46486 55781199
Fatigue 83.84 10.10 7569 456813 780983 55046702
Sedation complication 82.89 10.10 3 464379 11669 55816016
Feeling abnormal 82.31 10.10 705 463677 132897 55694788
Drug reaction with eosinophilia and systemic symptoms 78.87 10.10 80 464302 30224 55797461
Hepatic failure 78.81 10.10 96 464286 33390 55794295
Serotonin syndrome 78.45 10.10 62 464320 26428 55801257
No adverse event 77.73 10.10 112 464270 36262 55791423
Drug resistance 77.71 10.10 36 464346 20506 55807179
Blood cholesterol increased 77.51 10.10 928 463454 71651 55756034
Hypoglycaemia 75.83 10.10 223 464159 55592 55772093
Type 2 diabetes mellitus 75.45 10.10 652 463730 46210 55781475
Palmar-plantar erythrodysaesthesia syndrome 75.04 10.10 40 464342 21025 55806660
Renal impairment 73.92 10.10 378 464004 80335 55747350
Pulmonary arterial hypertension 73.61 10.10 66 464316 26437 55801248
Cognitive disorder 72.94 10.10 188 464194 48945 55778740
Sopor 71.26 10.10 42 464340 20880 55806805
Respiratory failure 71.17 10.10 475 463907 94587 55733098
Caesarean section 70.97 10.10 292 464090 15799 55811886
Foot deformity 70.44 10.10 385 463997 23440 55804245
Seizure 69.78 10.10 677 463705 124442 55703243
Coma 69.53 10.10 255 464127 59400 55768285
Ill-defined disorder 69.12 10.10 867 463515 67676 55760009
Red blood cell sedimentation rate increased 68.94 10.10 528 463854 36095 55791590
Joint effusion 68.61 10.10 274 464108 14624 55813061
Blood pressure fluctuation 68.40 10.10 568 463814 39792 55787893
Blood glucose increased 68.23 10.10 353 464029 74798 55752887
Vision blurred 67.99 10.10 403 463979 82540 55745145
Fluid retention 67.85 10.10 224 464158 53854 55773831
Hyperglycaemia 67.82 10.10 133 464249 38148 55789537
Basal cell carcinoma 67.60 10.10 397 463985 24824 55802861
Orthostatic hypotension 67.29 10.10 106 464276 33093 55794592
Chest discomfort 67.16 10.10 508 463874 98349 55729336
Congenital umbilical hernia 66.77 10.10 38 464344 275 55827410
Liver injury 65.69 10.10 579 463803 41269 55786416
Urticaria 65.50 10.10 821 463561 143855 55683830
Mental status changes 64.97 10.10 132 464250 37369 55790316
Neutrophil count decreased 64.86 10.10 203 464179 49619 55778066
Muscle spasms 64.67 10.10 773 463609 136598 55691087
Peripheral swelling 64.02 10.10 2454 461928 232272 55595413
White blood cell count decreased 63.58 10.10 698 463684 125292 55702393
Muscle spasticity 62.61 10.10 44 464338 19916 55807769
Creatinine renal clearance decreased 62.50 10.10 21 464361 14538 55813147
Intentional product use issue 62.40 10.10 1163 463219 98570 55729115
Hallucination 62.06 10.10 203 464179 48946 55778739
Atrial septal defect 62.01 10.10 154 464228 6352 55821333
Fibromyalgia 61.42 10.10 757 463625 58846 55768839
Metastases to bone 61.20 10.10 43 464339 19465 55808220
Myocardial infarction 60.86 10.10 482 463900 92388 55735297
Intentional product misuse 60.79 10.10 219 464163 51285 55776400
Metabolic acidosis 60.66 10.10 154 464228 40300 55787385
Disability assessment scale score increased 59.65 10.10 92 464290 2652 55825033
Contusion 58.18 10.10 1429 462953 127001 55700684
Multiple organ dysfunction syndrome 57.99 10.10 231 464151 52539 55775146
Ventricular septal defect 57.61 10.10 114 464268 4024 55823661
Diabetic ketoacidosis 57.37 10.10 43 464339 18828 55808857
Emotional distress 56.63 10.10 99 464283 29664 55798021
Blood pressure diastolic abnormal 56.40 10.10 217 464165 11381 55816304
Dehydration 56.25 10.10 946 463436 157879 55669806
Product dose omission issue 55.98 10.10 1274 463108 203479 55624206
Hospitalisation 55.51 10.10 376 464006 74624 55753061
C-reactive protein increased 55.42 10.10 935 463447 77749 55749936
Macular degeneration 55.06 10.10 45 464337 18863 55808822
Dysmorphism 54.99 10.10 79 464303 2134 55825551
Joint laxity 54.74 10.10 83 464299 2356 55825329
Sinusitis 54.41 10.10 2068 462314 195513 55632172
Bone erosion 54.10 10.10 256 464126 14718 55812967
COVID-19 53.72 10.10 380 464002 74678 55753007
Cytomegalovirus infection 53.65 10.10 48 464334 19248 55808437
Osteoporosis 53.59 10.10 661 463721 51391 55776294
Angioedema 53.18 10.10 170 464212 41283 55786402
Suicidal ideation 53.11 10.10 270 464112 57472 55770213
Mydriasis 52.99 10.10 13 464369 11058 55816627
Flushing 52.60 10.10 350 464032 69750 55757935
Drug ineffective for unapproved indication 52.10 10.10 82 464300 25611 55802074
Premature labour 51.91 10.10 215 464167 11667 55816018
Grip strength decreased 51.68 10.10 268 464114 15988 55811697
Pain in jaw 51.50 10.10 164 464218 39872 55787813
Acute hepatic failure 51.40 10.10 37 464345 16541 55811144
Injection site pruritus 51.01 10.10 550 463832 41381 55786304
Memory impairment 50.97 10.10 462 463920 86095 55741590
Injection site erythema 50.84 10.10 910 463472 76538 55751147
Decreased appetite 50.77 10.10 1398 462984 217833 55609852
Platelet count decreased 50.68 10.10 597 463785 105786 55721899
Blood pressure decreased 49.94 10.10 284 464098 58766 55768919
Ejection fraction decreased 49.81 10.10 54 464328 19787 55807898
Palpitations 49.17 10.10 555 463827 99117 55728568
Schizophrenia 48.96 10.10 13 464369 10486 55817199
Unresponsive to stimuli 48.95 10.10 119 464263 31606 55796079
Pulmonary embolism 48.81 10.10 607 463775 106517 55721168
Anaphylactic reaction 48.68 10.10 286 464096 58709 55768976
Dyspnoea exertional 48.46 10.10 259 464123 54430 55773255
Blood pressure systolic abnormal 48.42 10.10 184 464198 9593 55818092
Thrombocytopenia 48.35 10.10 811 463571 135413 55692272
Infection 48.08 10.10 2065 462317 198141 55629544
Maternal exposure before pregnancy 47.56 10.10 144 464238 6679 55821006
Loss of consciousness 47.45 10.10 626 463756 108723 55718962
Stomatitis 47.39 10.10 1319 463063 119491 55708194
Pre-eclampsia 47.34 10.10 166 464216 8320 55819365
Drug level increased 47.12 10.10 61 464321 20664 55807021
Inflammation 46.91 10.10 816 463566 68255 55759430
Abnormal behaviour 46.78 10.10 59 464323 20213 55807472
Respiratory depression 46.72 10.10 22 464360 12413 55815272
Respiratory disorder 46.61 10.10 135 464247 33822 55793863
Hepatic function abnormal 46.26 10.10 139 464243 34419 55793266
Poisoning 46.13 10.10 24 464358 12789 55814896
Encephalopathy 45.93 10.10 144 464238 35181 55792504
Neck deformity 45.32 10.10 69 464313 1966 55825719
Blood pressure systolic increased 45.29 10.10 526 463856 40310 55787375
Speech disorder 45.19 10.10 158 464224 37335 55790350
Dysgeusia 45.02 10.10 179 464203 40736 55786949
Back pain 44.99 10.10 1553 462829 235617 55592068
Anaemia 44.86 10.10 1778 462604 265733 55561952
Multiple fractures 44.82 10.10 148 464234 7193 55820492
Dysphagia 44.59 10.10 446 463936 81501 55746184
Loss of personal independence in daily activities 44.54 10.10 930 463452 80439 55747246
Blood calcium decreased 44.38 10.10 80 464302 23689 55803996
Cerebrovascular accident 44.29 10.10 565 463817 98705 55728980
Pancytopenia 44.11 10.10 1000 463382 87715 55739970
Polyarthritis 43.84 10.10 165 464217 8563 55819122
Blood creatine phosphokinase increased 43.80 10.10 104 464278 27848 55799837
Bone pain 43.73 10.10 239 464143 49946 55777739
Weight increased 43.65 10.10 2315 462067 227388 55600297
Ascites 42.76 10.10 162 464220 37382 55790303
Tuberculosis 42.38 10.10 192 464190 10837 55816848
Device dislocation 42.28 10.10 76 464306 22530 55805155
Pulmonary fibrosis 42.28 10.10 403 463979 29355 55798330
Premature delivery 42.26 10.10 374 464008 26686 55800999
Product use in unapproved indication 42.00 10.10 864 463518 139958 55687727
Joint range of motion decreased 41.92 10.10 355 464027 25010 55802675
Wrong technique in product usage process 41.86 10.10 294 464088 57874 55769811
Metastases to liver 41.80 10.10 71 464311 21515 55806170
Disturbance in attention 41.36 10.10 134 464248 32406 55795279
Joint destruction 41.35 10.10 113 464269 4942 55822743
Torsade de pointes 40.93 10.10 26 464356 12414 55815271
Maternal drugs affecting foetus 40.82 10.10 113 464269 4980 55822705
Shock 40.68 10.10 73 464309 21655 55806030
Pulmonary oedema 40.59 10.10 251 464131 50892 55776793
Chest pain 40.47 10.10 1224 463158 188573 55639112
Premature rupture of membranes 40.47 10.10 108 464274 4657 55823028
Respiratory disorder neonatal 39.98 10.10 44 464338 900 55826785
Akathisia 39.81 10.10 11 464371 8641 55819044
Blood alkaline phosphatase increased 39.38 10.10 176 464206 38769 55788916
Headache 39.27 10.10 4026 460356 555018 55272667
Dysarthria 39.23 10.10 180 464202 39370 55788315
Extrapyramidal disorder 39.07 10.10 27 464355 12329 55815356
Altered state of consciousness 39.06 10.10 82 464300 22939 55804746
Device difficult to use 38.97 10.10 20 464362 10741 55816944
Breast cancer metastatic 38.94 10.10 42 464340 15427 55812258
Multiple sclerosis 38.54 10.10 110 464272 27692 55799993
Restlessness 38.49 10.10 103 464279 26483 55801202
Hypothermia 38.44 10.10 28 464354 12442 55815243
Aspartate aminotransferase increased 38.40 10.10 466 463916 82136 55745549
Infective pulmonary exacerbation of cystic fibrosis 38.23 10.10 10 464372 8147 55819538
Drug tolerance decreased 37.83 10.10 214 464168 13197 55814488
Pulmonary hypertension 37.83 10.10 160 464222 35784 55791901
General physical health deterioration 37.82 10.10 1740 462642 168270 55659415
Neuroleptic malignant syndrome 37.75 10.10 24 464358 11454 55816231
Haemorrhage 37.73 10.10 291 464091 56106 55771579
Withdrawal syndrome 37.36 10.10 59 464323 18403 55809282
Chronic kidney disease 37.35 10.10 199 464183 41857 55785828
Anaphylactic shock 37.25 10.10 77 464305 21663 55806022
Disability 37.01 10.10 240 464142 15540 55812145
Blood bilirubin increased 36.65 10.10 146 464236 33208 55794477
Psychotic disorder 36.63 10.10 88 464294 23470 55804215
Blood pressure diastolic decreased 36.59 10.10 279 464103 19044 55808641
Atrial fibrillation 36.48 10.10 655 463727 108242 55719443
Neurotoxicity 36.41 10.10 46 464336 15749 55811936
Rheumatoid nodule 36.10 10.10 228 464154 14629 55813056
Developmental hip dysplasia 35.85 10.10 49 464333 1262 55826423
Juvenile idiopathic arthritis 35.42 10.10 103 464279 4670 55823015
Injection site reaction 35.42 10.10 627 463755 52620 55775065
Cytokine release syndrome 35.41 10.10 23 464359 10852 55816833
Mania 35.34 10.10 26 464356 11494 55816191
Arrhythmia 35.20 10.10 159 464223 34924 55792761
Alanine aminotransferase increased 35.08 10.10 552 463830 93110 55734575
Hypokalaemia 34.23 10.10 560 463822 93877 55733808
Ventricular tachycardia 34.21 10.10 54 464328 16847 55810838
Osteonecrosis of jaw 34.18 10.10 150 464232 33208 55794477
Joint stiffness 33.97 10.10 444 463938 34981 55792704
Disorientation 33.78 10.10 171 464211 36442 55791243
Latent tuberculosis 33.72 10.10 68 464314 2434 55825251
Sepsis 33.58 10.10 887 463495 138953 55688732
Brain oedema 33.45 10.10 36 464346 13235 55814450
Injection site swelling 33.34 10.10 525 463857 43053 55784632
Posterior reversible encephalopathy syndrome 33.26 10.10 50 464332 15910 55811775
Lethargy 33.22 10.10 268 464114 51173 55776512
Accidental exposure to product 33.09 10.10 99 464283 24548 55803137
Deep vein thrombosis 32.90 10.10 442 463940 76535 55751150
Irritability 32.84 10.10 129 464253 29459 55798226
Large for dates baby 32.76 10.10 29 464353 450 55827235
Pleural effusion 32.28 10.10 503 463879 84977 55742708
Dyskinesia 32.24 10.10 127 464255 28981 55798704
Ventricular fibrillation 31.97 10.10 26 464356 10926 55816759
Blood creatinine increased 31.95 10.10 467 463915 79724 55747961
Depressed mood 31.76 10.10 173 464209 36186 55791499
Obstructive airways disorder 31.52 10.10 59 464323 17223 55810462
Haematotoxicity 31.23 10.10 15 464367 8368 55819317
Foetal death 31.16 10.10 147 464235 8440 55819245
Product administration error 31.12 10.10 80 464302 20849 55806836
Nightmare 31.08 10.10 57 464325 16769 55810916
Talipes 30.86 10.10 48 464334 1394 55826291
Enthesopathy 30.71 10.10 140 464242 7923 55819762
Unevaluable event 30.53 10.10 249 464133 47438 55780247
Disease recurrence 30.50 10.10 98 464284 23762 55803923
Respiratory distress 30.31 10.10 146 464236 31521 55796164
Acute respiratory failure 30.19 10.10 142 464240 30852 55796833
Joint dislocation 30.01 10.10 228 464154 15545 55812140
Bronchospasm 29.92 10.10 52 464330 15617 55812068
Limb deformity 29.82 10.10 85 464297 3810 55823875
Laryngitis 29.75 10.10 207 464175 13723 55813962
Nodule 29.41 10.10 258 464124 18361 55809324
Complication associated with device 29.26 10.10 51 464331 15299 55812386
International normalised ratio increased 29.11 10.10 228 464154 43813 55783872
Coagulopathy 29.03 10.10 70 464312 18646 55809039
Device use error 29.02 10.10 5 464377 5451 55822234
Pulmonary tuberculosis 28.92 10.10 92 464290 4384 55823301
Dystonia 28.82 10.10 36 464346 12385 55815300
Dry skin 28.80 10.10 249 464133 46860 55780825
Skin ulcer 28.73 10.10 463 463919 38145 55789540
Gastrointestinal haemorrhage 28.65 10.10 447 463935 75504 55752181
Musculoskeletal pain 28.52 10.10 874 463508 80278 55747407
Transplant rejection 28.48 10.10 24 464358 9910 55817775
Disseminated intravascular coagulation 28.46 10.10 66 464316 17819 55809866
Vertigo 28.45 10.10 300 464082 54272 55773413
Foetal anticonvulsant syndrome 28.38 10.10 29 464353 543 55827142
Metastases to central nervous system 28.34 10.10 35 464347 12101 55815584
Leukopenia 28.31 10.10 413 463969 70527 55757158
Panic attack 28.27 10.10 81 464301 20366 55807319
Tenderness 28.16 10.10 272 464110 19883 55807802
Complication of device insertion 28.04 10.10 9 464373 6415 55821270
Hyperkalaemia 28.01 10.10 276 464106 50589 55777096
Fear 27.99 10.10 50 464332 14858 55812827
Gamma-glutamyltransferase increased 27.93 10.10 146 464236 30859 55796826
Post transplant lymphoproliferative disorder 27.88 10.10 3 464379 4669 55823016
Localised infection 27.73 10.10 347 464035 27065 55800620
Hypervolaemia 27.70 10.10 118 464264 26340 55801345
Nervousness 27.63 10.10 134 464248 28881 55798804
Malignant melanoma 27.62 10.10 167 464215 10552 55817133
Blood potassium decreased 27.56 10.10 196 464186 38476 55789209
Status epilepticus 27.34 10.10 52 464330 15089 55812596
Hypomania 27.19 10.10 4 464378 4898 55822787
Hyperlipidaemia 27.10 10.10 69 464313 18040 55809645
Polyneuropathy 27.08 10.10 41 464341 13009 55814676
Graft versus host disease 27.05 10.10 11 464371 6770 55820915
Cardiogenic shock 26.99 10.10 59 464323 16266 55811419
Femur fracture 26.95 10.10 465 463917 38830 55788855
Substance abuse 26.77 10.10 3 464379 4522 55823163
Lupus-like syndrome 26.74 10.10 185 464197 12242 55815443
Product adhesion issue 26.45 10.10 3 464379 4480 55823205
Second primary malignancy 26.45 10.10 14 464368 7388 55820297
Glycosylated haemoglobin increased 26.28 10.10 32 464350 11133 55816552
Parkinsonism 26.24 10.10 24 464358 9522 55818163
Tardive dyskinesia 26.13 10.10 17 464365 8014 55819671
Tenosynovitis stenosans 26.11 10.10 63 464319 2551 55825134
Crying 26.07 10.10 90 464292 21350 55806335
Cardiac failure acute 25.98 10.10 21 464361 8852 55818833
Infusion site pain 25.98 10.10 46 464336 13716 55813969
Synovial cyst 25.97 10.10 147 464235 9067 55818618
Muscular weakness 25.74 10.10 660 463722 103792 55723893
Gastrointestinal disorder 25.59 10.10 1156 463226 111546 55716139
Haemorrhage intracranial 25.58 10.10 41 464341 12714 55814971
Atrioventricular block complete 25.58 10.10 15 464367 7479 55820206
Asphyxia 25.47 10.10 8 464374 5781 55821904
Tenosynovitis 25.35 10.10 183 464199 12278 55815407
Placental disorder 25.21 10.10 44 464338 1409 55826276
Inappropriate antidiuretic hormone secretion 25.06 10.10 47 464335 13709 55813976
Hemiparesis 24.94 10.10 92 464290 21398 55806287
Anhedonia 24.87 10.10 27 464355 9887 55817798
Birth mark 24.82 10.10 15 464367 123 55827562
Heart rate decreased 24.77 10.10 470 463912 39957 55787728
Psoriasis 24.72 10.10 967 463415 91725 55735960
Hepatotoxicity 24.66 10.10 153 464229 31000 55796685
Genital haemorrhage 24.49 10.10 13 464369 6849 55820836
Polyhydramnios 24.46 10.10 54 464328 2061 55825624
Bradyphrenia 24.43 10.10 12 464370 6608 55821077
Abdominal distension 24.41 10.10 472 463910 77154 55750531
Thrombotic microangiopathy 24.31 10.10 25 464357 9386 55818299
Muscle twitching 24.22 10.10 62 464320 16180 55811505
Tumour lysis syndrome 24.15 10.10 18 464364 7905 55819780
Acute graft versus host disease 24.12 10.10 3 464379 4172 55823513
Blood pressure diastolic increased 23.75 10.10 136 464246 8425 55819260
Uterine perforation 23.69 10.10 12 464370 6493 55821192
Venoocclusive liver disease 23.63 10.10 4 464378 4417 55823268
Smear cervix abnormal 23.58 10.10 63 464319 2718 55824967
Sinus tachycardia 23.56 10.10 100 464282 22344 55805341
Hypomagnesaemia 23.55 10.10 116 464266 24899 55802786
Myelosuppression 23.51 10.10 70 464312 17385 55810300
Malaise 23.51 10.10 2666 461716 365194 55462491
Arthritis infective 23.12 10.10 104 464278 5852 55821833
Pancreatitis 23.02 10.10 249 464133 44831 55782854
Cholestasis 22.99 10.10 129 464253 26784 55800901
Cerebral haemorrhage 22.90 10.10 140 464242 28466 55799219
Sleep apnoea syndrome 22.76 10.10 124 464258 25937 55801748
Abortion late 22.75 10.10 14 464368 119 55827566
Aspergillus infection 22.70 10.10 17 464365 7448 55820237
Patent ductus arteriosus 22.66 10.10 78 464304 3873 55823812
Speech disorder developmental 22.62 10.10 27 464355 605 55827080
Skin exfoliation 22.57 10.10 195 464187 36705 55790980
Aggression 22.52 10.10 99 464283 21907 55805778
Swollen tongue 22.44 10.10 152 464230 30172 55797513
Wheelchair user 22.40 10.10 97 464285 5369 55822316
Injection site rash 22.30 10.10 226 464156 16732 55810953
Agitation neonatal 22.27 10.10 24 464358 479 55827206
Paralysis 22.21 10.10 25 464357 9007 55818678
Accidental overdose 22.20 10.10 90 464292 20371 55807314
Exomphalos 22.09 10.10 25 464357 528 55827157
Face oedema 22.07 10.10 78 464304 18374 55809311
Maternal exposure timing unspecified 22.04 10.10 96 464286 5327 55822358
Stevens-Johnson syndrome 21.97 10.10 104 464278 22559 55805126
Blood glucose decreased 21.96 10.10 82 464300 19005 55808680
Proteinuria 21.88 10.10 73 464309 17497 55810188
Cytopenia 21.88 10.10 29 464353 9726 55817959
Melaena 21.85 10.10 140 464242 28150 55799535
Cholecystitis chronic 21.84 10.10 29 464353 9719 55817966
Lymphocyte count decreased 21.71 10.10 138 464244 27801 55799884
Stress cardiomyopathy 21.70 10.10 22 464360 8314 55819371
Muscle rigidity 21.69 10.10 34 464348 10637 55817048
Therapeutic response decreased 21.52 10.10 579 463803 52179 55775506
Device related infection 21.45 10.10 100 464282 21780 55805905
Pulmonary congestion 21.44 10.10 65 464317 16050 55811635
Tachypnoea 21.42 10.10 61 464321 15369 55812316
Infantile vomiting 21.37 10.10 13 464369 108 55827577
Injection site pain 21.34 10.10 1176 463206 115942 55711743
Angina pectoris 21.32 10.10 139 464243 27837 55799848
Delirium 21.25 10.10 236 464146 42281 55785404
Anaemia macrocytic 21.17 10.10 65 464317 3038 55824647
Myopathy 21.17 10.10 30 464352 9782 55817903
Skin papilloma 21.02 10.10 83 464299 4406 55823279
Adverse event 20.97 10.10 602 463780 54774 55772911
Neck mass 20.92 10.10 69 464313 3351 55824334
Erythema multiforme 20.82 10.10 29 464353 9525 55818160
Lip swelling 20.81 10.10 129 464253 26143 55801542
Hot flush 20.81 10.10 266 464116 46460 55781225
Multiple allergies 20.81 10.10 34 464348 10462 55817223
Synovial fluid analysis 20.76 10.10 48 464334 1890 55825795
Hypophagia 20.75 10.10 146 464236 28730 55798955
Diabetes mellitus 20.69 10.10 308 464074 52427 55775258
Mood altered 20.68 10.10 50 464332 13305 55814380
Dislocation of vertebra 20.61 10.10 94 464288 5321 55822364
Atrioventricular block 20.54 10.10 16 464366 6871 55820814
Retinitis 20.51 10.10 79 464303 4145 55823540
Metastases to lung 20.51 10.10 41 464341 11677 55816008
Pathogen resistance 20.49 10.10 12 464370 5988 55821697
Red blood cell sedimentation rate 20.45 10.10 80 464302 4228 55823457
Exposure to toxic agent 20.40 10.10 3 464379 3675 55824010
Dysuria 20.34 10.10 159 464223 30570 55797115
Loose body in joint 20.27 10.10 37 464345 1228 55826457
Mental disorder 20.24 10.10 113 464269 23491 55804194
Complication of device removal 20.22 10.10 6 464376 4498 55823187
Myocarditis 20.21 10.10 26 464356 8832 55818853
Haemorrhage in pregnancy 20.15 10.10 45 464337 1731 55825954
Acute myeloid leukaemia 20.13 10.10 72 464310 16900 55810785
Infusion site erythema 20.11 10.10 30 464352 9576 55818109
Coronary artery disease 20.08 10.10 160 464222 30636 55797049
Colitis 19.76 10.10 235 464147 41576 55786109
Respiration abnormal 19.67 10.10 11 464371 5630 55822055
Personality disorder 19.67 10.10 9 464373 5164 55822521
Hypophosphataemia 19.64 10.10 31 464351 9671 55818014
Chills 19.62 10.10 671 463711 101933 55725752
Pseudomonas infection 19.61 10.10 33 464349 10038 55817647
Abdominal pain 19.59 10.10 1853 462529 256952 55570733
Hallucination, auditory 19.59 10.10 41 464341 11483 55816202
Body temperature decreased 19.52 10.10 232 464150 17876 55809809
Infusion site swelling 19.40 10.10 22 464360 7899 55819786
Vascular device infection 19.35 10.10 11 464371 5579 55822106
Dermatitis atopic 19.31 10.10 24 464358 8275 55819410
Breast cancer stage I 19.19 10.10 14 464368 6216 55821469
Breast feeding 19.18 10.10 29 464353 821 55826864
Jaundice 19.12 10.10 139 464243 27155 55800530
Acute chest syndrome 19.10 10.10 26 464356 667 55827018
Ketoacidosis 19.09 10.10 5 464377 4070 55823615
Right ventricular failure 19.09 10.10 70 464312 16309 55811376
Neonatal respiratory distress syndrome 19.08 10.10 58 464324 2696 55824989
Catheter site erythema 19.06 10.10 5 464377 4065 55823620
Hereditary angioedema 19.00 10.10 17 464365 6818 55820867
Dementia 18.92 10.10 75 464307 17083 55810602
Miosis 18.81 10.10 16 464366 6576 55821109
Abortion threatened 18.77 10.10 23 464359 530 55827155
Stillbirth 18.76 10.10 101 464281 6113 55821572
Injection site bruising 18.76 10.10 433 463949 38088 55789597
Pericardial effusion 18.75 10.10 139 464243 27036 55800649
Febrile bone marrow aplasia 18.69 10.10 16 464366 6556 55821129
Fracture 18.62 10.10 229 464153 17789 55809896
Cough 18.60 10.10 1869 462513 258092 55569593
Premature baby 18.53 10.10 241 464141 18964 55808721
Aphasia 18.48 10.10 161 464221 30254 55797431
Immune reconstitution inflammatory syndrome 18.48 10.10 12 464370 5662 55822023
Incorrect route of product administration 18.34 10.10 102 464280 21227 55806458
Rotator cuff repair 18.29 10.10 45 464337 1845 55825840
Device breakage 18.19 10.10 35 464347 10112 55817573
Clostridium difficile colitis 18.16 10.10 86 464296 18652 55809033
Acidosis 18.16 10.10 37 464345 10464 55817221
Toxic epidermal necrolysis 18.10 10.10 107 464275 21935 55805750
Lip dry 18.09 10.10 140 464242 9600 55818085
Learning disorder 18.07 10.10 24 464358 601 55827084
Mouth ulceration 17.96 10.10 344 464038 29296 55798389
Fall 17.94 10.10 2631 461751 354879 55472806
Renal disorder 17.86 10.10 157 464225 29448 55798237
Anger 17.83 10.10 44 464338 11628 55816057
Leukocytosis 17.73 10.10 119 464263 23672 55804013
Acute generalised exanthematous pustulosis 17.73 10.10 34 464348 9835 55817850
Peripheral venous disease 17.69 10.10 143 464239 9936 55817749
Bradycardia neonatal 17.61 10.10 28 464354 829 55826856
Oedema peripheral 17.60 10.10 1196 463186 170058 55657627
Spinal stenosis 17.59 10.10 185 464197 13829 55813856
Haematoma 17.52 10.10 174 464208 31845 55795840
Wound infection 17.43 10.10 197 464185 14996 55812689
Renal injury 17.42 10.10 29 464353 8858 55818827
Product preparation error 17.37 10.10 9 464373 4807 55822878
Delusion 17.35 10.10 42 464340 11173 55816512
Body height below normal 17.33 10.10 46 464336 1977 55825708
Infusion site pruritus 17.31 10.10 9 464373 4798 55822887
Bronchopulmonary aspergillosis 17.11 10.10 26 464356 8238 55819447
Cerebral infarction 17.06 10.10 112 464270 22393 55805292
Tubulointerstitial nephritis 17.03 10.10 75 464307 16590 55811095
Congenital hydronephrosis 17.02 10.10 19 464363 395 55827290
Head injury 16.92 10.10 129 464253 24937 55802748
Bradypnoea 16.90 10.10 3 464379 3200 55824485
Restless legs syndrome 16.88 10.10 77 464305 16870 55810815
Chronic obstructive pulmonary disease 16.88 10.10 353 464029 57062 55770623
Subdural haematoma 16.87 10.10 56 464326 13443 55814242
Haemoptysis 16.86 10.10 139 464243 26421 55801264
Bronchioloalveolar carcinoma 16.85 10.10 10 464372 79 55827606
Treatment noncompliance 16.73 10.10 180 464202 32443 55795242
Fracture delayed union 16.72 10.10 50 464332 2303 55825382
Multiple-drug resistance 16.60 10.10 6 464376 3968 55823717
Congenital arterial malformation 16.56 10.10 17 464365 320 55827365
Cushingoid 16.52 10.10 111 464271 7273 55820412
Serum ferritin increased 16.50 10.10 90 464292 5475 55822210
Malignant mediastinal neoplasm 16.48 10.10 28 464354 877 55826808
Klebsiella infection 16.45 10.10 24 464358 7732 55819953
Clear cell renal cell carcinoma 16.39 10.10 34 464348 1242 55826443
Polyuria 16.38 10.10 23 464359 7528 55820157
Eating disorder 16.29 10.10 79 464303 17026 55810659
Herpes zoster 16.27 10.10 774 463608 75115 55752570
Facet joint syndrome 16.27 10.10 103 464279 6614 55821071
Cyanosis 16.25 10.10 71 464311 15739 55811946
Immunosuppression 16.22 10.10 117 464265 7847 55819838
Hyperprolactinaemia 16.21 10.10 5 464377 3656 55824029
Induced labour 16.16 10.10 28 464354 891 55826794
Taste disorder 16.15 10.10 35 464347 9680 55818005
Oliguria 16.12 10.10 28 464354 8412 55819273
Colitis microscopic 16.09 10.10 25 464357 7850 55819835
Scleritis 16.09 10.10 67 464315 3644 55824041
Abortion missed 16.07 10.10 39 464343 1585 55826100
Device issue 16.02 10.10 105 464277 21001 55806684
Pemphigoid 15.98 10.10 17 464365 6283 55821402
Joint noise 15.97 10.10 68 464314 3736 55823949
Cardiotoxicity 15.91 10.10 24 464358 7626 55820059
Off label use 15.85 10.10 4214 460168 551966 55275719
Rash erythematous 15.80 10.10 214 464168 37007 55790678
Cholestasis of pregnancy 15.80 10.10 32 464350 1149 55826536
Synovial disorder 15.71 10.10 31 464351 1092 55826593
Hyperthyroidism 15.60 10.10 57 464325 13295 55814390
Body temperature increased 15.59 10.10 194 464188 34048 55793637
Potentiating drug interaction 15.58 10.10 7 464375 4059 55823626
Catheter site pain 15.51 10.10 8 464374 4285 55823400
Transplant dysfunction 15.50 10.10 10 464372 4736 55822949
Affective disorder 15.50 10.10 14 464368 5589 55822096
Diabetes mellitus inadequate control 15.48 10.10 61 464321 13919 55813766
Visual acuity reduced 15.28 10.10 104 464278 20622 55807063
Peripheral sensory neuropathy 15.28 10.10 21 464361 6935 55820750
Anuria 15.24 10.10 48 464334 11712 55815973
Congenital hypertrichosis 15.22 10.10 4 464378 0 55827685
Gastroenteritis viral 15.22 10.10 245 464137 20179 55807506
Visual impairment 15.19 10.10 481 463901 73721 55753964
Schizoaffective disorder 15.05 10.10 3 464379 2946 55824739
Blood iron increased 15.02 10.10 35 464347 1385 55826300
Foetal distress syndrome 14.99 10.10 33 464349 1257 55826428
Pregnancy with contraceptive device 14.92 10.10 8 464374 4191 55823494
Tinnitus 14.92 10.10 167 464215 29875 55797810
Catatonia 14.91 10.10 7 464375 3957 55823728
Prescribed underdose 14.88 10.10 246 464136 20371 55807314
Hypoglycaemia neonatal 14.83 10.10 27 464355 894 55826791
Salivary hypersecretion 14.77 10.10 22 464360 7028 55820657
Product substitution issue 14.74 10.10 66 464316 14533 55813152
Pulseless electrical activity 14.64 10.10 22 464360 7002 55820683
Colorectal cancer 14.62 10.10 5 464377 3424 55824261
Fear of injection 14.62 10.10 98 464284 6417 55821268
Product complaint 14.55 10.10 49 464333 11711 55815974
Paranoia 14.53 10.10 43 464339 10701 55816984
Mobility decreased 14.48 10.10 975 463407 98016 55729669
Full blood count decreased 14.46 10.10 123 464259 23226 55804459
Anti-cyclic citrullinated peptide antibody 14.45 10.10 65 464317 3658 55824027
Dactylitis 14.44 10.10 44 464338 2048 55825637
Drug abuser 14.40 10.10 3 464379 2856 55824829
Full blood count abnormal 14.39 10.10 144 464238 26318 55801367
Generalised oedema 14.38 10.10 66 464316 14435 55813250
Retrognathia 14.35 10.10 18 464364 425 55827260
Lymphoedema 14.35 10.10 42 464340 10488 55817197
Sexual dysfunction 14.35 10.10 5 464377 3383 55824302
Throat tightness 14.34 10.10 117 464265 22290 55805395
Epistaxis 14.32 10.10 432 463950 66591 55761094
Abnormal dreams 14.26 10.10 37 464345 9612 55818073
Pyrexia 14.23 10.10 3147 461235 415626 55412059
Antinuclear antibody positive 14.22 10.10 101 464281 6740 55820945
Incorrect product administration duration 14.21 10.10 41 464341 10285 55817400
Postoperative wound infection 14.17 10.10 128 464254 9185 55818500
Amylase increased 14.16 10.10 16 464366 5755 55821930
Hypertelorism 14.13 10.10 18 464364 432 55827253
Cardiac disorder 14.12 10.10 280 464102 45607 55782078
Adjustment disorder with depressed mood 14.11 10.10 81 464301 5022 55822663
Sleep disorder due to a general medical condition 14.10 10.10 34 464348 9056 55818629
Tumour marker increased 14.09 10.10 9 464373 4284 55823401
Immunodeficiency 14.05 10.10 199 464183 15958 55811727
Injection site haematoma 14 10.10 94 464288 6158 55821527
Toxic encephalopathy 14.00 10.10 17 464365 5921 55821764
Flatulence 13.97 10.10 178 464204 31110 55796575
Autism spectrum disorder 13.94 10.10 24 464358 760 55826925
Procedural pain 13.89 10.10 78 464304 16193 55811492
Human antichimeric antibody positive 13.86 10.10 36 464346 1527 55826158
Cardiomyopathy 13.85 10.10 78 464304 16180 55811505
Amniotic fluid volume increased 13.83 10.10 11 464371 146 55827539
Paraesthesia 13.82 10.10 909 463473 129605 55698080
Toxic skin eruption 13.79 10.10 50 464332 11689 55815996
Somnambulism 13.76 10.10 13 464369 5079 55822606
Dialysis 13.73 10.10 38 464344 9664 55818021
Gestational hypertension 13.72 10.10 46 464336 2253 55825432
Urinary incontinence 13.70 10.10 167 464215 29418 55798267
Therapy change 13.70 10.10 15 464367 5473 55822212
Normal newborn 13.67 10.10 107 464275 7363 55820322
Hypothyroidism 13.67 10.10 227 464155 37969 55789716
Congenital tricuspid valve atresia 13.64 10.10 7 464375 40 55827645
Naevus flammeus 13.61 10.10 10 464372 117 55827568
Presyncope 13.59 10.10 140 464242 25442 55802243
Urinary retention 13.57 10.10 157 464225 27917 55799768
Hypernatraemia 13.54 10.10 21 464361 6599 55821086
Psychomotor hyperactivity 13.50 10.10 39 464343 9781 55817904
Chronic graft versus host disease 13.46 10.10 5 464377 3251 55824434
Tendonitis 13.45 10.10 217 464165 17880 55809805
Pneumonia viral 13.44 10.10 24 464358 7134 55820551
Ataxia 13.44 10.10 67 464315 14336 55813349
Embedded device 13.41 10.10 4 464378 2989 55824696
Bone lesion 13.39 10.10 15 464367 5415 55822270
Sinus bradycardia 13.37 10.10 62 464320 13524 55814161
Lordosis 13.37 10.10 14 464368 270 55827415
Twin pregnancy 13.36 10.10 29 464353 1094 55826591
Abdominal pain upper 13.29 10.10 1278 463104 177035 55650650
Middle insomnia 13.29 10.10 46 464336 10904 55816781
Product physical issue 13.22 10.10 11 464371 4571 55823114
Drug screen positive 13.21 10.10 6 464376 3458 55824227
Pharyngitis streptococcal 13.18 10.10 128 464254 9370 55818315
Respiratory acidosis 13.14 10.10 19 464363 6144 55821541
Skin cancer 13.14 10.10 137 464245 10218 55817467
Pancreatitis acute 13.14 10.10 138 464244 24986 55802699
Human herpesvirus 6 infection 13.13 10.10 3 464379 2679 55825006
Bursitis 13.11 10.10 309 464073 27273 55800412
Antibody test positive 13.09 10.10 47 464335 2384 55825301
B-cell lymphoma 13.07 10.10 59 464323 3325 55824360
Injection site warmth 13.02 10.10 177 464205 14066 55813619
Hygroma colli 13.01 10.10 5 464377 12 55827673
Arthritis bacterial 12.98 10.10 89 464293 5872 55821813
Exostosis 12.98 10.10 184 464198 14759 55812926
Placental insufficiency 12.98 10.10 32 464350 1314 55826371
Ear pain 12.97 10.10 178 464204 30712 55796973
Chondropathy 12.92 10.10 44 464338 2173 55825512
Myoclonus 12.91 10.10 73 464309 15130 55812555
Ankylosing spondylitis 12.90 10.10 132 464250 9798 55817887
Oxygen consumption increased 12.78 10.10 7 464375 3624 55824061
Laryngospasm 12.66 10.10 4 464378 2880 55824805
Foetal growth restriction 12.61 10.10 101 464281 6998 55820687
Systemic inflammatory response syndrome 12.56 10.10 15 464367 5263 55822422
Pain in extremity 12.52 10.10 2705 461677 294726 55532959
Folate deficiency 12.50 10.10 43 464339 2134 55825551
Paraesthesia oral 12.48 10.10 69 464313 14380 55813305
Acute myocardial infarction 12.45 10.10 176 464206 30217 55797468
Fine motor skill dysfunction 12.43 10.10 71 464311 4394 55823291
Squamous cell carcinoma 12.40 10.10 112 464270 8036 55819649
Blood sodium decreased 12.37 10.10 121 464261 22213 55805472
Cleft palate 12.37 10.10 26 464356 959 55826726
Progressive multifocal leukoencephalopathy 12.32 10.10 54 464328 11959 55815726
Oral herpes 12.31 10.10 261 464121 22629 55805056
Catheter management 12.26 10.10 4 464378 2822 55824863
Feeling hot 12.26 10.10 257 464125 41530 55786155
Threatened labour 12.25 10.10 23 464359 780 55826905
Food allergy 12.17 10.10 35 464347 8789 55818896
Ileus 12.15 10.10 66 464316 13816 55813869
Ageusia 12.15 10.10 57 464325 12394 55815291
Heart rate increased 12.14 10.10 562 463820 82711 55744974
Obesity 12.09 10.10 256 464126 22192 55805493
Ear infection 12.07 10.10 341 464041 30954 55796731
Sickle cell anaemia 12.06 10.10 19 464363 558 55827127
Arnold-Chiari malformation 12.06 10.10 20 464362 614 55827071
Plasma cell myeloma recurrent 11.91 10.10 4 464378 2770 55824915
Application site pain 11.83 10.10 9 464373 3911 55823774
Occult blood 11.80 10.10 29 464353 1188 55826497
Madarosis 11.77 10.10 4 464378 2749 55824936
Haemophagocytic lymphohistiocytosis 11.76 10.10 40 464342 9532 55818153
Toxoplasma serology positive 11.76 10.10 5 464377 17 55827668
Corneal degeneration 11.76 10.10 8 464374 82 55827603
Breast cancer female 11.74 10.10 57 464325 12281 55815404
Polydipsia 11.73 10.10 6 464376 3229 55824456
Congenital skin dimples 11.72 10.10 9 464373 113 55827572
Blood pressure inadequately controlled 11.71 10.10 12 464370 4512 55823173
Pulmonary haemorrhage 11.64 10.10 24 464358 6759 55820926
Small cell carcinoma 11.63 10.10 10 464372 149 55827536
Rectal haemorrhage 11.59 10.10 257 464125 41210 55786475
Laboratory test abnormal 11.59 10.10 139 464243 24556 55803129
Rheumatoid lung 11.57 10.10 54 464328 3086 55824599
Hypoplastic left heart syndrome 11.57 10.10 11 464371 188 55827497
Syndactyly 11.55 10.10 14 464368 319 55827366
Extra dose administered 11.55 10.10 17 464365 5456 55822229
Rebound effect 11.53 10.10 9 464373 3861 55823824
Anal prolapse 11.52 10.10 8 464374 85 55827600
Pancreatic steatosis 11.52 10.10 25 464357 943 55826742
Thrombosis 11.50 10.10 388 463994 59039 55768646
Coronary arterial stent insertion 11.47 10.10 4 464378 2706 55824979
Graft versus host disease in skin 11.45 10.10 4 464378 2703 55824982
Human anti-human antibody test 11.45 10.10 16 464366 421 55827264
Hypoplastic right heart syndrome 11.42 10.10 7 464375 59 55827626
Congenital pulmonary artery anomaly 11.42 10.10 3 464379 0 55827685
Double ureter 11.42 10.10 3 464379 0 55827685
Cervical incompetence 11.41 10.10 19 464363 585 55827100
Lung transplant 11.40 10.10 5 464377 2942 55824743
Rhinitis allergic 11.40 10.10 34 464348 8440 55819245
Influenza like illness 11.39 10.10 400 463982 60588 55767097
Adenovirus infection 11.38 10.10 7 464375 3401 55824284
Trigeminal neuralgia 11.38 10.10 7 464375 3400 55824285
Wound infection pseudomonas 11.37 10.10 30 464352 1285 55826400
Troponin increased 11.36 10.10 35 464347 8600 55819085
Lymphatic fistula 11.36 10.10 22 464360 764 55826921
Eosinophil count increased 11.35 10.10 41 464341 9596 55818089
Device deployment issue 11.35 10.10 8 464374 3616 55824069
Labelled drug-drug interaction medication error 11.33 10.10 53 464329 11533 55816152
Motor dysfunction 11.30 10.10 40 464342 9417 55818268
Aspiration 11.29 10.10 41 464341 9580 55818105
Rash maculo-papular 11.28 10.10 169 464213 28738 55798947
Autoimmune haemolytic anaemia 11.26 10.10 67 464315 4209 55823476
Bacteraemia 11.24 10.10 79 464303 15552 55812133
Paradoxical drug reaction 11.24 10.10 9 464373 3811 55823874
Joint warmth 11.23 10.10 32 464350 1434 55826251
Inadequate analgesia 11.21 10.10 4 464378 2667 55825018
Hepatic cytolysis 11.20 10.10 49 464333 10857 55816828
Swelling face 11.11 10.10 365 464017 55704 55771981
Breast cancer stage II 11.09 10.10 19 464363 5739 55821946
Femoral hernia incarcerated 11.07 10.10 22 464360 779 55826906
Prothrombin consumption time prolonged 11.07 10.10 6 464376 39 55827646
Embolism 11.06 10.10 28 464354 7336 55820349
Oligohydramnios 11.04 10.10 86 464296 5908 55821777
Ulcer 11.02 10.10 253 464129 22232 55805453
Congenital cerebral cyst 11.02 10.10 11 464371 200 55827485
Forceps delivery 10.93 10.10 11 464371 202 55827483
Joint lock 10.86 10.10 41 464341 2131 55825554
Mental impairment 10.85 10.10 61 464321 12661 55815024
Oropharyngeal pain 10.83 10.10 817 463565 82971 55744714
Maternal exposure during breast feeding 10.82 10.10 59 464323 3588 55824097
Teratoma benign 10.77 10.10 7 464375 66 55827619
Failed induction of labour 10.77 10.10 14 464368 343 55827342
Product administered to patient of inappropriate age 10.76 10.10 5 464377 2843 55824842
Intracranial pressure increased 10.73 10.10 13 464369 4532 55823153
Post-traumatic stress disorder 10.69 10.10 13 464369 4525 55823160
Post procedural haemorrhage 10.68 10.10 29 464353 7420 55820265
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.62 10.10 4 464378 2579 55825106
Acute coronary syndrome 10.58 10.10 43 464339 9725 55817960
Hypertransaminasaemia 10.55 10.10 14 464368 4693 55822992
Mycobacterium tuberculosis complex test positive 10.51 10.10 38 464344 1934 55825751
Haemodialysis 10.49 10.10 36 464346 8555 55819130
Amniotic fluid volume decreased 10.45 10.10 16 464366 458 55827227
Deep vein thrombosis postoperative 10.44 10.10 63 464319 3978 55823707
Multiple drug therapy 10.40 10.10 5 464377 2787 55824898
Anterior chamber cleavage syndrome 10.37 10.10 10 464372 174 55827511
Disseminated tuberculosis 10.36 10.10 48 464334 2735 55824950
Neonatal infection 10.36 10.10 9 464373 136 55827549
Onychomycosis 10.35 10.10 91 464291 6481 55821204
Congenital oesophageal anomaly 10.30 10.10 4 464378 10 55827675
Pyelonephritis acute 10.25 10.10 66 464316 4263 55823422
Nail injury 10.25 10.10 17 464365 522 55827163
Tonsillitis 10.24 10.10 76 464306 5144 55822541
Erythema 10.21 10.10 1128 463254 154811 55672874
Eosinophilia 10.21 10.10 111 464271 19966 55807719
Wrong technique in device usage process 10.18 10.10 6 464376 2984 55824701
Tongue disorder 10.13 10.10 127 464255 9909 55817776
Pharyngeal oedema 10.13 10.10 66 464316 13219 55814466

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 808.17 10.12 1037 166400 39839 31490068
Rheumatoid arthritis 451.14 10.12 863 166574 46946 31482961
Drug abuse 346.58 10.12 32 167405 87726 31442181
Toxicity to various agents 285.50 10.12 323 167114 181164 31348743
Completed suicide 249.40 10.12 86 167351 91428 31438479
Arthralgia 204.79 10.12 1435 166002 149989 31379918
Dysmorphism 204.33 10.12 152 167285 2920 31526987
Atrial septal defect 195.37 10.12 211 167226 6716 31523191
Premature baby 161.55 10.12 319 167118 17747 31512160
Hypospadias 161.39 10.12 133 167304 2983 31526924
Small for dates baby 148.85 10.12 136 167301 3519 31526388
Psoriatic arthropathy 143.91 10.12 322 167115 19561 31510346
Sickle cell anaemia with crisis 125.93 10.12 112 167325 2795 31527112
Ventricular septal defect 117.98 10.12 120 167317 3557 31526350
Speech disorder developmental 111.97 10.12 91 167346 2000 31527907
Death 109.24 10.12 1300 166137 359269 31170638
Drug interaction 106.68 10.12 655 166782 207888 31322019
Joint swelling 105.48 10.12 559 166878 52872 31477035
Cryptorchism 103.30 10.12 85 167352 1902 31528005
Maternal exposure during pregnancy 99.61 10.12 123 167314 4533 31525374
Foetal anticonvulsant syndrome 96.55 10.12 66 167371 1103 31528804
Intentional overdose 94.95 10.12 50 167387 41339 31488568
Neonatal respiratory distress syndrome 93.56 10.12 109 167328 3776 31526131
Congenital umbilical hernia 90.99 10.12 40 167397 258 31529649
Musculoskeletal stiffness 86.15 10.12 439 166998 40886 31489021
Enthesopathy 84.95 10.12 109 167328 4178 31525729
Pancytopenia 83.58 10.12 765 166672 86551 31443356
Autism spectrum disorder 80.39 10.12 77 167360 2118 31527789
Hypoglycaemia neonatal 79.87 10.12 70 167367 1712 31528195
Respiratory disorder neonatal 77.82 10.12 64 167373 1431 31528476
Exposure during pregnancy 75.86 10.12 151 167286 8447 31521460
Tenosynovitis 75.62 10.12 102 167335 4108 31525799
Low birth weight baby 74.67 10.12 133 167304 6837 31523070
Hypotonia neonatal 72.28 10.12 58 167379 1251 31528656
Learning disorder 71.91 10.12 53 167384 1003 31528904
Maternal drugs affecting foetus 70.77 10.12 95 167342 3808 31526099
Talipes 69.97 10.12 66 167371 1780 31528127
Developmental delay 69.37 10.12 77 167360 2528 31527379
Foot deformity 69.22 10.12 97 167340 4052 31525855
Agitation neonatal 68.50 10.12 52 167385 1031 31528876
Suicide attempt 67.97 10.12 58 167379 37190 31492717
Syndactyly 67.12 10.12 47 167390 818 31529089
Blood pressure fluctuation 65.68 10.12 266 167171 22470 31507437
Synovitis 65.55 10.12 177 167260 12106 31517801
Product use in unapproved indication 61.35 10.12 292 167145 98879 31431028
Drug resistance 57.32 10.12 26 167411 23427 31506480
Nasopharyngitis 55.45 10.12 544 166893 62701 31467206
Language disorder 55.24 10.12 62 167375 2061 31527846
Rheumatoid nodule 54.44 10.12 69 167368 2612 31527295
Renal aplasia 54.14 10.12 38 167399 664 31529243
Serotonin syndrome 54.00 10.12 16 167421 18757 31511150
Drug dependence 53.69 10.12 26 167411 22553 31507354
Febrile neutropenia 52.60 10.12 402 167035 121447 31408460
Intellectual disability 52.54 10.12 47 167390 1182 31528725
Rhabdomyolysis 52.26 10.12 167 167270 63414 31466493
C-reactive protein abnormal 51.98 10.12 122 167315 7647 31522260
Overdose 51.36 10.12 251 167186 84413 31445494
Coma 50.76 10.12 87 167350 41063 31488844
Disease progression 49.93 10.12 277 167160 90187 31439720
Palmar-plantar erythrodysaesthesia syndrome 48.73 10.12 11 167426 15472 31514435
Maternal exposure during breast feeding 48.69 10.12 50 167387 1499 31528408
Psoriasis 48.62 10.12 417 167020 46302 31483605
Arthropathy 48.37 10.12 253 167184 23798 31506109
Joint laxity 48.34 10.12 29 167408 382 31529525
Hepatic function abnormal 48.28 10.12 90 167347 41132 31488775
Selective eating disorder 47.81 10.12 52 167385 1668 31528239
Pain 47.49 10.12 1307 166130 185452 31344455
Nasal disorder 47.44 10.12 52 167385 1683 31528224
Exposure via breast milk 46.15 10.12 53 167384 1807 31528100
Drug reaction with eosinophilia and systemic symptoms 45.36 10.12 55 167382 29963 31499944
Foetal growth restriction 45.05 10.12 76 167361 3739 31526168
Drug withdrawal syndrome neonatal 44.51 10.12 72 167365 3420 31526487
Basal cell carcinoma 44.27 10.12 202 167235 17977 31511930
Tongue disorder 44.12 10.12 88 167349 4929 31524978
Hypertonia neonatal 44.07 10.12 28 167409 411 31529496
Dysgraphia 44.03 10.12 56 167381 2127 31527780
Hyperbilirubinaemia neonatal 43.38 10.12 34 167403 708 31529199
Arthritis 43.20 10.12 270 167167 27115 31502792
C-reactive protein increased 41.92 10.12 417 167020 48233 31481674
Alanine aminotransferase abnormal 41.60 10.12 75 167362 3892 31526015
Blood pressure systolic increased 40.67 10.12 207 167230 19263 31510644
Pulmonary fibrosis 40.48 10.12 185 167252 16475 31513432
Hypertelorism 40.07 10.12 29 167408 533 31529374
Large for dates baby 39.97 10.12 35 167402 855 31529052
Bradycardia neonatal 39.96 10.12 36 167401 914 31528993
General physical health deterioration 39.80 10.12 830 166607 112605 31417302
Plagiocephaly 39.18 10.12 28 167409 504 31529403
Suicidal ideation 38.77 10.12 84 167353 36322 31493585
Ear disorder 38.42 10.12 42 167395 1355 31528552
Motor developmental delay 38.06 10.12 30 167407 630 31529277
Constipation 37.72 10.12 446 166991 123545 31406362
Intentional product misuse 37.63 10.12 91 167346 37860 31492047
Birth mark 36.96 10.12 18 167419 151 31529756
Patent ductus arteriosus 36.89 10.12 63 167374 3130 31526777
Osteoarthritis 36.58 10.12 198 167239 18869 31511038
Renal failure 36.22 10.12 447 166990 122883 31407024
Haemangioma congenital 36.15 10.12 26 167411 473 31529434
Drug withdrawal syndrome 35.69 10.12 28 167409 18722 31511185
Behaviour disorder 35.57 10.12 74 167363 4273 31525634
Strabismus 35.28 10.12 43 167394 1563 31528344
Blood pressure diastolic abnormal 35.24 10.12 70 167367 3909 31525998
Bradycardia 35.20 10.12 218 167219 69109 31460798
Joint effusion 33.85 10.12 75 167362 4524 31525383
Hypermobility syndrome 33.77 10.12 22 167415 338 31529569
Congenital hydronephrosis 33.75 10.12 29 167408 690 31529217
Psychomotor retardation 33.49 10.12 61 167376 3191 31526716
Caesarean section 33.40 10.12 46 167391 1890 31528017
Blood pressure systolic abnormal 33.18 10.12 59 167378 3028 31526879
Astigmatism 32.90 10.12 34 167403 1027 31528880
Respiratory arrest 32.85 10.12 55 167382 26202 31503705
Sedation 32.83 10.12 31 167406 18934 31510973
Cleft lip and palate 32.57 10.12 24 167413 454 31529453
Hand deformity 32.45 10.12 58 167379 2989 31526918
Altered state of consciousness 32.41 10.12 38 167399 21013 31508894
Congenital hand malformation 32.27 10.12 26 167411 564 31529343
Pectus excavatum 31.96 10.12 18 167419 209 31529698
Bronchiolitis 31.86 10.12 56 167381 2848 31527059
Infusion related reaction 31.81 10.12 391 167046 47664 31482243
Spina bifida 31.66 10.12 21 167416 333 31529574
Angioedema 31.48 10.12 83 167354 33535 31496372
Off label use 31.46 10.12 1507 165930 345767 31184140
Blood creatine phosphokinase increased 31.26 10.12 115 167322 41859 31488048
Drug intolerance 30.91 10.12 415 167022 51618 31478289
Cardiac arrest 30.81 10.12 311 167126 88751 31441156
Ear infection 30.67 10.12 110 167327 8771 31521136
Jaundice neonatal 30.51 10.12 36 167401 1264 31528643
Delirium 30.51 10.12 114 167323 41307 31488600
Abnormal palmar/plantar creases 29.99 10.12 17 167420 200 31529707
Pathogen resistance 29.88 10.12 5 167432 8696 31521211
Knee deformity 29.73 10.12 25 167412 577 31529330
Poisoning 29.62 10.12 9 167428 10382 31519525
Polydactyly 29.59 10.12 34 167403 1160 31528747
Somnolence 29.35 10.12 360 167077 99085 31430822
Low set ears 29.12 10.12 22 167415 433 31529474
Kidney duplex 28.97 10.12 21 167416 387 31529520
Tendonitis 28.70 10.12 105 167332 8453 31521454
Urticaria 28.61 10.12 182 167255 57335 31472572
Psychotic disorder 28.54 10.12 46 167391 22247 31507660
Dyspraxia 28.47 10.12 21 167416 398 31529509
Otitis media 28.12 10.12 50 167387 2566 31527341
Folate deficiency 27.74 10.12 33 167404 1169 31528738
Agitation 27.66 10.12 170 167267 53999 31475908
Red blood cell sedimentation rate increased 27.66 10.12 102 167335 8244 31521663
Polyarthritis 27.61 10.12 66 167371 4186 31525721
Neuroleptic malignant syndrome 27.57 10.12 29 167408 16840 31513067
Single umbilical artery 27.32 10.12 16 167421 201 31529706
Attention deficit hyperactivity disorder 27.29 10.12 47 167390 2351 31527556
Lower respiratory tract infection 27.28 10.12 248 167189 27989 31501918
Pain in extremity 27.20 10.12 805 166632 115398 31414509
Congenital tricuspid valve incompetence 26.91 10.12 14 167423 137 31529770
Hydrocele 26.80 10.12 42 167395 1941 31527966
Anal fistula 26.61 10.12 70 167367 4713 31525194
Plasma cell myeloma 26.05 10.12 183 167254 56348 31473559
Knee arthroplasty 25.95 10.12 85 167352 6473 31523434
Microcephaly 25.47 10.12 26 167411 774 31529133
Electrocardiogram QT prolonged 25.17 10.12 109 167328 37878 31492029
Blood pressure diastolic decreased 24.95 10.12 96 167341 7917 31521990
Substance abuse 24.83 10.12 4 167433 7154 31522753
Serum ferritin increased 24.67 10.12 77 167360 5715 31524192
Scoliosis 24.57 10.12 47 167390 2552 31527355
Fine motor skill dysfunction 24.54 10.12 37 167400 1653 31528254
Acute kidney injury 24.47 10.12 1218 166219 278496 31251411
Haemoglobin decreased 24.35 10.12 773 166664 111902 31418005
Congenital knee deformity 24.21 10.12 12 167425 105 31529802
Developmental coordination disorder 24.18 10.12 14 167423 172 31529735
Neonatal seizure 23.70 10.12 20 167417 464 31529443
Respiratory failure 23.64 10.12 385 167052 101064 31428843
Sopor 23.61 10.12 16 167421 11536 31518371
Educational problem 23.61 10.12 21 167416 524 31529383
Shock 23.49 10.12 53 167384 22592 31507315
Musculoskeletal pain 23.46 10.12 251 167186 29577 31500330
Foetal disorder 23.41 10.12 25 167412 785 31529122
Hyperglycaemia 23.36 10.12 106 167331 36370 31493537
Congenital astigmatism 23.28 10.12 8 167429 23 31529884
Multiple organ dysfunction syndrome 23.23 10.12 239 167198 67964 31461943
Weight decrease neonatal 23.23 10.12 17 167420 318 31529589
Medical device implantation 23.18 10.12 22 167415 598 31529309
Inflammation 23.03 10.12 219 167218 25022 31504885
Grip strength decreased 22.78 10.12 46 167391 2600 31527307
Heart rate decreased 22.77 10.12 239 167198 28027 31501880
Blood pressure increased 22.70 10.12 566 166871 79067 31450840
Enuresis 22.53 10.12 41 167396 2143 31527764
Acute hepatic failure 22.28 10.12 21 167416 12838 31517069
Vitamin B12 deficiency 22.18 10.12 54 167383 3465 31526442
Ectopic kidney 22.11 10.12 8 167429 28 31529879
Post transplant lymphoproliferative disorder 21.99 10.12 3 167434 6073 31523834
Vitamin D deficiency 21.80 10.12 75 167362 5857 31524050
Joint range of motion decreased 21.73 10.12 81 167356 6580 31523327
Peripheral swelling 21.67 10.12 490 166947 67375 31462532
Infective pulmonary exacerbation of cystic fibrosis 21.66 10.12 4 167433 6480 31523427
Cytomegalovirus infection 21.64 10.12 63 167374 24644 31505263
Malignant neoplasm progression 21.45 10.12 291 167146 78707 31451200
Dermatitis psoriasiform 21.44 10.12 29 167408 1171 31528736
Depressed level of consciousness 21.39 10.12 118 167319 38483 31491424
No adverse event 21.12 10.12 45 167392 19580 31510327
Body temperature decreased 21.09 10.12 120 167317 11650 31518257
Cleft palate 21.07 10.12 21 167416 607 31529300
Dyslexia 21.04 10.12 16 167421 318 31529589
Unresponsive to stimuli 21.02 10.12 68 167369 25732 31504175
Hepatic failure 20.96 10.12 95 167342 32607 31497300
Foetal heart rate deceleration abnormality 20.87 10.12 19 167418 489 31529418
Joint stiffness 20.55 10.12 106 167331 9915 31519992
Hallucination 20.52 10.12 152 167285 46258 31483649
Prognathism 20.52 10.12 11 167426 115 31529792
Skin cancer 20.46 10.12 101 167336 9284 31520623
Ankyloglossia congenital 20.44 10.12 15 167422 282 31529625
Appendicolith 20.34 10.12 3 167434 5728 31524179
Congenital myopia 20.22 10.12 9 167428 60 31529847
Hypoglycaemia 20.15 10.12 172 167265 50774 31479133
Wrong technique in product usage process 20.11 10.12 99 167338 33244 31496663
Pyelocaliectasis 20.08 10.12 27 167410 1084 31528823
Clinodactyly 20.03 10.12 14 167423 243 31529664
Product quality issue 19.92 10.12 34 167403 16077 31513830
Drug ineffective for unapproved indication 19.82 10.12 40 167397 17750 31512157
Tuberculosis 19.80 10.12 92 167345 8249 31521658
Psychomotor skills impaired 19.73 10.12 48 167389 3079 31526828
Multiple congenital abnormalities 19.70 10.12 19 167418 527 31529380
Inguinal hernia 19.66 10.12 81 167356 6894 31523013
Pulmonary artery stenosis congenital 19.62 10.12 18 167419 468 31529439
Diaphragmatic disorder 19.52 10.12 27 167410 1114 31528793
Therapeutic product effect decreased 19.52 10.12 254 167183 31368 31498539
Wound 19.48 10.12 126 167311 12802 31517105
Congenital bladder anomaly 19.26 10.12 14 167423 259 31529648
Pyloric stenosis 19.25 10.12 22 167415 746 31529161
Limb reduction defect 19.22 10.12 14 167423 260 31529647
Congenital anomaly 19.06 10.12 29 167408 1306 31528601
Oesophageal fibrosis 19.01 10.12 12 167425 174 31529733
Kinematic imbalances due to suboccipital strain 18.96 10.12 6 167431 12 31529895
Strabismus congenital 18.82 10.12 7 167430 27 31529880
Tooth malformation 18.72 10.12 12 167425 179 31529728
Respiratory depression 18.51 10.12 30 167407 14480 31515427
Floppy infant 18.46 10.12 10 167427 107 31529800
Hydrops foetalis 18.44 10.12 17 167420 445 31529462
Toxic epidermal necrolysis 18.43 10.12 48 167389 19476 31510431
Hypermetropia 18.31 10.12 17 167420 449 31529458
Post procedural infection 18.23 10.12 59 167378 4464 31525443
Congenital foot malformation 18.20 10.12 16 167421 393 31529514
Neonatal respiratory distress 18.04 10.12 18 167419 521 31529386
Umbilical hernia 17.93 10.12 56 167381 4158 31525749
Blood parathyroid hormone decreased 17.87 10.12 28 167409 1294 31528613
Squamous cell carcinoma of lung 17.83 10.12 34 167403 1842 31528065
Kyphosis congenital 17.80 10.12 5 167432 5 31529902
Epispadias 17.76 10.12 11 167426 154 31529753
Ear malformation 17.72 10.12 14 167423 295 31529612
Neurotoxicity 17.64 10.12 37 167400 16189 31513718
Maternal exposure before pregnancy 17.44 10.12 20 167417 681 31529226
Camptodactyly congenital 17.40 10.12 10 167427 121 31529786
Loss of personal independence in daily activities 17.36 10.12 227 167210 28061 31501846
Radiation inflammation 17.25 10.12 18 167419 550 31529357
Lacrimal disorder 17.17 10.12 14 167423 309 31529598
Prominent epicanthal folds 17.17 10.12 11 167426 164 31529743
Weight decreased 17.09 10.12 1020 166417 158932 31370975
Cleft lip 17.06 10.12 14 167423 312 31529595
Hernia congenital 17.00 10.12 4 167433 0 31529907
Red blood cell sedimentation rate 16.95 10.12 24 167413 1012 31528895
Venoocclusive liver disease 16.92 10.12 9 167428 7403 31522504
Bronchial carcinoma 16.90 10.12 23 167414 934 31528973
Arthritis bacterial 16.84 10.12 58 167379 4532 31525375
Granuloma skin 16.76 10.12 25 167412 1106 31528801
Latent tuberculosis 16.65 10.12 26 167411 1198 31528709
Finger deformity 16.63 10.12 26 167411 1199 31528708
Cardiac failure 16.62 10.12 337 167100 85616 31444291
Spinal disorder 16.59 10.12 52 167385 3868 31526039
Haemangioma 16.57 10.12 32 167405 1750 31528157
Blood pressure diastolic increased 16.56 10.12 55 167382 4218 31525689
Lung neoplasm malignant 16.42 10.12 144 167293 16086 31513821
Diabetic ketoacidosis 16.39 10.12 41 167396 16864 31513043
Poor venous access 16.25 10.12 53 167384 4027 31525880
Accessory spleen 15.96 10.12 10 167427 143 31529764
Micropenis 15.94 10.12 7 167430 45 31529862
Temperature regulation disorder 15.90 10.12 18 167419 604 31529303
Microphthalmos 15.88 10.12 11 167426 188 31529719
Pseudolymphoma 15.86 10.12 17 167420 536 31529371
Neck mass 15.68 10.12 29 167408 1535 31528372
Intentional self-injury 15.65 10.12 29 167408 13286 31516621
Vomiting 15.58 10.12 997 166440 222976 31306931
Fine motor delay 15.55 10.12 12 167425 244 31529663
Haematocrit decreased 15.54 10.12 234 167203 29827 31500080
Aspergillus infection 15.51 10.12 23 167414 11505 31518402
Kyphosis 15.41 10.12 24 167413 1103 31528804
Poor sucking reflex 15.25 10.12 13 167424 306 31529601
Lower respiratory tract congestion 15.23 10.12 23 167414 1029 31528878
Nodule 15.20 10.12 65 167372 5625 31524282
Cerebral haemorrhage neonatal 15.10 10.12 12 167425 255 31529652
Pallor 15.07 10.12 183 167254 22241 31507666
Incorrect route of product administration 15.02 10.12 24 167413 11649 31518258
Encopresis 15 10.12 10 167427 160 31529747
Heart disease congenital 14.98 10.12 26 167411 1309 31528598
C-reactive protein decreased 14.97 10.12 31 167406 1784 31528123
Cholelithiasis 14.89 10.12 163 167274 19316 31510591
Myopia 14.88 10.12 23 167414 1050 31528857
Juvenile idiopathic arthritis 14.77 10.12 30 167407 1703 31528204
Cerebral ventricle dilatation 14.74 10.12 21 167416 891 31529016
Arthrodesis 14.73 10.12 15 167422 445 31529462
Pharyngeal disorder 14.67 10.12 18 167419 659 31529248
Congenital cerebral cyst 14.64 10.12 5 167432 14 31529893
Arnold-Chiari malformation 14.60 10.12 13 167424 325 31529582
Obsessive-compulsive disorder 14.58 10.12 4 167433 4933 31524974
Haemolysis 14.57 10.12 76 167361 7140 31522767
Oesophageal adenocarcinoma 14.46 10.12 20 167417 825 31529082
Cardiogenic shock 14.41 10.12 65 167372 22343 31507564
Cystitis haemorrhagic 14.34 10.12 5 167432 5284 31524623
Coarctation of the aorta 14.33 10.12 15 167422 460 31529447
Diverticular perforation 14.31 10.12 43 167394 3126 31526781
Craniosynostosis 14.30 10.12 13 167424 334 31529573
Hepatic cyst 14.27 10.12 36 167401 2362 31527545
Oesophageal atresia 14.25 10.12 15 167422 463 31529444
Iron deficiency 14.22 10.12 44 167393 3250 31526657
Oropharyngeal discomfort 14.21 10.12 39 167398 2692 31527215
Gross motor delay 14.20 10.12 12 167425 279 31529628
Hypoxia 14.14 10.12 184 167253 50129 31479778
Erectile dysfunction 14.12 10.12 53 167384 19182 31510725
Malignant melanoma 14.09 10.12 79 167358 7628 31522279
Immunosuppression 14.08 10.12 63 167374 5560 31524347
Anaemia 14.07 10.12 1310 166127 212212 31317695
Anal fissure 14.07 10.12 45 167392 3384 31526523
Blood folate decreased 14.06 10.12 18 167419 688 31529219
Anal atresia 14.05 10.12 12 167425 283 31529624
Stevens-Johnson syndrome 14.00 10.12 46 167391 17326 31512581
Sexual dysfunction 13.99 10.12 7 167430 5961 31523946
Oropharyngeal pain 13.99 10.12 239 167198 31244 31498663
Developmental hip dysplasia 13.98 10.12 12 167425 285 31529622
Visuospatial deficit 13.98 10.12 8 167429 96 31529811
Oxygen saturation decreased 13.96 10.12 349 167088 48766 31481141
Depression 13.93 10.12 369 167068 90446 31439461
Brain stem auditory evoked response abnormal 13.93 10.12 5 167432 17 31529890
Abnormal labour affecting foetus 13.93 10.12 5 167432 17 31529890
Foetal distress syndrome 13.89 10.12 22 167415 1026 31528881
Pulmonary valve stenosis 13.86 10.12 13 167424 348 31529559
Haematochezia 13.81 10.12 295 167142 40169 31489738
Communication disorder 13.77 10.12 36 167401 2414 31527493
Muscle spasms 13.76 10.12 266 167171 68052 31461855
Peritoneal tuberculosis 13.65 10.12 13 167424 355 31529552
Immunodeficiency 13.52 10.12 55 167382 4654 31525253
Cardio-respiratory arrest 13.51 10.12 192 167245 51534 31478373
Micrognathia 13.51 10.12 12 167425 299 31529608
Congenital megaureter 13.50 10.12 9 167428 144 31529763
BK virus infection 13.50 10.12 5 167432 5090 31524817
Septic arthritis staphylococcal 13.47 10.12 15 167422 494 31529413
Renal impairment 13.47 10.12 350 167087 85999 31443908
Hyperammonaemia 13.44 10.12 7 167430 5826 31524081
Maternal exposure timing unspecified 13.44 10.12 13 167424 362 31529545
Trisomy 18 13.44 10.12 13 167424 362 31529545
Asthma 13.43 10.12 152 167285 42459 31487448
Hypotension 13.18 10.12 917 166520 203701 31326206
Congenital mitral valve incompetence 13.10 10.12 8 167429 109 31529798
Proteinuria 13.09 10.12 45 167392 16718 31513189
Dactylitis 13.02 10.12 19 167418 824 31529083
Hepatitis E antibody positive 13.01 10.12 11 167426 256 31529651
Neutropenia neonatal 13.00 10.12 17 167420 664 31529243
Bursitis 12.99 10.12 57 167380 4988 31524919
Infantile apnoea 12.93 10.12 20 167417 914 31528993
Emphysema 12.88 10.12 86 167351 8832 31521075
Hernia pain 12.79 10.12 11 167426 262 31529645
Suspected suicide 12.76 10.12 3 167434 4104 31525803
Umbilical granuloma 12.75 10.12 3 167434 0 31529907
Pyrexia 12.73 10.12 1408 166029 302432 31227475
Respiratory rate increased 12.66 10.12 88 167349 9157 31520750
Irritability 12.66 10.12 70 167367 22819 31507088
Hepatic enzyme increased 12.65 10.12 263 167174 35645 31494262
Myalgia 12.63 10.12 311 167126 76947 31452960
Poikiloderma 12.59 10.12 9 167428 162 31529745
Abnormal behaviour 12.57 10.12 74 167363 23754 31506153
Ventricular fibrillation 12.53 10.12 54 167383 18794 31511113
Neuropathy peripheral 12.50 10.12 304 167133 75345 31454562
Acquired plagiocephaly 12.46 10.12 6 167431 49 31529858
Anaphylactic shock 12.44 10.12 36 167401 14109 31515798
Meningeal disorder 12.41 10.12 12 167425 334 31529573
Paranoia 12.39 10.12 23 167414 10532 31519375
Thinking abnormal 12.39 10.12 7 167430 5566 31524341
Akathisia 12.38 10.12 12 167425 7241 31522666
Duodenal atresia 12.33 10.12 4 167433 9 31529898
Synovial cyst 12.29 10.12 31 167406 2034 31527873
Vascular insufficiency 12.26 10.12 12 167425 339 31529568
Learning disability 12.26 10.12 12 167425 339 31529568
Back disorder 12.18 10.12 64 167373 6029 31523878
Hypotelorism of orbit 12.16 10.12 8 167429 125 31529782
Acute chest syndrome 12.15 10.12 12 167425 343 31529564
Pleural fibrosis 12.10 10.12 24 167413 1339 31528568
Mean cell volume increased 12.06 10.12 38 167399 2834 31527073
Hepatitis E virus test positive 12.06 10.12 11 167426 284 31529623
Adenovirus infection 12.04 10.12 5 167432 4749 31525158
Blood insulin increased 12.04 10.12 12 167425 347 31529560
Meconium in amniotic fluid 11.96 10.12 5 167432 28 31529879
Ligament laxity 11.96 10.12 5 167432 28 31529879
Congenital eye disorder 11.95 10.12 8 167429 129 31529778
Dysphonia 11.93 10.12 62 167375 20529 31509378
Cytogenetic abnormality 11.91 10.12 18 167419 806 31529101
Mouth ulceration 11.90 10.12 98 167339 10750 31519157
Nausea 11.88 10.12 1435 166002 306512 31223395
Personal relationship issue 11.87 10.12 11 167426 290 31529617
Pulmonary valve stenosis congenital 11.84 10.12 8 167429 131 31529776
Akinesia 11.80 10.12 30 167407 1978 31527929
Placental insufficiency 11.75 10.12 7 167430 91 31529816
Joint contracture 11.72 10.12 28 167409 1775 31528132
Seizure 11.72 10.12 420 167017 99348 31430559
Transplant rejection 11.54 10.12 21 167416 9687 31520220
Skin indentation 11.51 10.12 4 167433 12 31529895
Palindromic rheumatism 11.50 10.12 9 167428 187 31529720
Axonal neuropathy 11.46 10.12 20 167417 1011 31528896
Nose deformity 11.46 10.12 9 167428 188 31529719
Gastrointestinal infection 11.44 10.12 53 167384 4747 31525160
Lung cancer metastatic 11.43 10.12 35 167402 2571 31527336
Rheumatoid lung 11.38 10.12 17 167420 753 31529154
Foetal hypokinesia 11.36 10.12 12 167425 372 31529535
Arthritis infective 11.34 10.12 38 167399 2927 31526980
Tooth injury 11.33 10.12 21 167416 1113 31528794
Gangrene neonatal 11.30 10.12 9 167428 192 31529715
Aplasia pure red cell 11.29 10.12 60 167377 5677 31524230
Potentiating drug interaction 11.20 10.12 5 167432 4548 31525359
Peritoneal dialysis complication 11.20 10.12 26 167411 1618 31528289
Lordosis 11.19 10.12 10 167427 251 31529656
Laryngomalacia 11.15 10.12 11 167426 314 31529593
Haptoglobin decreased 11.13 10.12 14 167423 526 31529381
End stage renal disease 11.08 10.12 16 167421 8093 31521814
Steatorrhoea 11.07 10.12 16 167421 688 31529219
Cardiac septal defect 11.06 10.12 10 167427 255 31529652
Hypotony maculopathy 11.05 10.12 4 167433 14 31529893
Hypotonia 11.04 10.12 70 167367 7063 31522844
Infection 11.04 10.12 534 166903 81397 31448510
Drug level increased 11.02 10.12 62 167375 20124 31509783
Congenital cystic kidney disease 11.01 10.12 12 167425 386 31529521
Aggression 10.99 10.12 135 167302 37156 31492751
Gastric haemorrhage 10.96 10.12 22 167415 9783 31520124
Crohn's disease 10.95 10.12 47 167390 4074 31525833
Peripheral artery thrombosis 10.93 10.12 31 167406 2181 31527726
Congenital aortic valve incompetence 10.92 10.12 8 167429 150 31529757
Scleroedema 10.91 10.12 5 167432 36 31529871
Anaemia folate deficiency 10.91 10.12 5 167432 36 31529871
Adenomatous polyposis coli 10.87 10.12 8 167429 151 31529756
Muscle tone disorder 10.87 10.12 8 167429 151 31529756
Autosomal chromosome anomaly 10.84 10.12 4 167433 15 31529892
Reticulocytosis 10.81 10.12 10 167427 263 31529644
Congenital torticollis 10.78 10.12 6 167431 68 31529839
High arched palate 10.78 10.12 6 167431 68 31529839
Panniculitis 10.73 10.12 27 167410 1769 31528138
Infected dermal cyst 10.72 10.12 17 167420 794 31529113
Gastrooesophageal sphincter insufficiency 10.70 10.12 6 167431 69 31529838
Renal dysplasia 10.69 10.12 9 167428 208 31529699
Urinary tract malformation 10.68 10.12 3 167434 3 31529904
Central nervous system mass 10.55 10.12 7 167430 111 31529796
Congenital genital malformation 10.55 10.12 7 167430 111 31529796
Dystonia 10.55 10.12 24 167413 10201 31519706
Neonatal infection 10.55 10.12 12 167425 405 31529502
Wall motion score index abnormal 10.50 10.12 7 167430 112 31529795
Second primary malignancy 10.50 10.12 13 167424 7019 31522888
Dermatitis acneiform 10.49 10.12 9 167428 5758 31524149
Neurodevelopmental disorder 10.45 10.12 12 167425 409 31529498
Congenital melanocytic naevus 10.45 10.12 4 167433 17 31529890
Localised infection 10.44 10.12 125 167312 15140 31514767
Neonatal hyponatraemia 10.41 10.12 6 167431 73 31529834
Excessive cerumen production 10.41 10.12 10 167427 276 31529631
Body dysmorphic disorder 10.39 10.12 7 167430 114 31529793
Neuroendocrine tumour of the lung metastatic 10.34 10.12 7 167430 115 31529792
Aorticopulmonary septal defect 10.27 10.12 4 167433 18 31529889
Glycosylated haemoglobin increased 10.26 10.12 25 167412 10375 31519532
Foetal heart rate abnormal 10.23 10.12 8 167429 166 31529741
Cardiotoxicity 10.22 10.12 7 167430 5020 31524887
JC virus CSF test positive 10.19 10.12 7 167430 118 31529789
Aplasia cutis congenita 10.19 10.12 7 167430 118 31529789
Intestinal stenosis 10.18 10.12 28 167409 1935 31527972
Pulmonary arterial hypertension 10.17 10.12 23 167414 9798 31520109
Complications of transplanted kidney 10.17 10.12 5 167432 4300 31525607
Tonsil cancer 10.16 10.12 19 167418 1014 31528893

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1631.04 9.96 4991 473412 286814 70163227
Completed suicide 1030.80 9.96 152 478251 226983 70223058
Pemphigus 881.94 9.96 1816 476587 81220 70368821
Arthropathy 870.62 9.96 2603 475800 147454 70302587
Toxicity to various agents 855.60 9.96 791 477612 381381 70068660
Systemic lupus erythematosus 854.43 9.96 2027 476376 99875 70350166
Joint swelling 848.49 9.96 3669 474734 249542 70200499
Hand deformity 848.42 9.96 1831 476572 84651 70365390
Synovitis 825.02 9.96 2320 476083 126908 70323133
Glossodynia 758.41 9.96 1751 476652 84736 70365305
Maternal exposure during pregnancy 739.36 9.96 2074 476329 113271 70336770
Drug abuse 687.97 9.96 90 478313 147166 70302875
Arthralgia 674.98 9.96 5740 472663 497650 69952391
Anti-cyclic citrullinated peptide antibody positive 646.40 9.96 1449 476954 68736 70381305
Wound 635.32 9.96 1778 476625 96954 70353087
Pericarditis 626.32 9.96 1606 476797 83099 70366942
Infusion related reaction 620.09 9.96 2808 475595 194726 70255315
Abdominal discomfort 485.28 9.96 2783 475620 211875 70238166
Therapeutic product effect decreased 473.41 9.96 2066 476337 140952 70309089
Death 472.59 9.96 1807 476596 508254 69941787
Discomfort 470.35 9.96 1673 476730 103763 70346278
Alopecia 464.20 9.96 2597 475806 195893 70254148
Exposure during pregnancy 458.50 9.96 1468 476935 86249 70363792
Swelling 457.06 9.96 2491 475912 186048 70263993
Pain 451.45 9.96 6332 472071 622484 69827557
Contraindicated product administered 422.41 9.96 1914 476489 132698 70317343
Duodenal ulcer perforation 399.53 9.96 990 477413 50122 70399919
Helicobacter infection 391.55 9.96 1036 477367 54620 70395421
Nasopharyngitis 380.13 9.96 2684 475719 219522 70230519
Rheumatoid factor positive 372.55 9.96 932 477471 47468 70402573
Musculoskeletal stiffness 372.06 9.96 1973 476430 145787 70304254
Hepatic enzyme increased 368.19 9.96 2056 476347 154934 70295107
Drug intolerance 365.83 9.96 2691 475712 222996 70227045
Intentional overdose 351.15 9.96 113 478290 98322 70351719
Drug interaction 306.06 9.96 1427 476976 380014 70070027
Febrile neutropenia 271.57 9.96 610 477793 203708 70246333
Impaired healing 271.24 9.96 1107 477296 73267 70376774
Psoriatic arthropathy 252.18 9.96 984 477419 63787 70386254
C-reactive protein abnormal 232.64 9.96 679 477724 37900 70412141
Product use issue 228.07 9.96 2029 476374 177908 70272133
Cardiac arrest 224.98 9.96 462 477941 159372 70290669
Gestational diabetes 224.15 9.96 238 478165 5763 70444278
Muscle injury 224.02 9.96 669 477734 37825 70412216
Sinusitis 218.10 9.96 1915 476488 167280 70282761
Hypersensitivity 214.76 9.96 2433 475970 227379 70222662
Folliculitis 213.79 9.96 703 477700 41867 70408174
Peripheral swelling 212.80 9.96 2486 475917 234077 70215964
Lower respiratory tract infection 212.10 9.96 1387 477016 110526 70339515
Treatment failure 210.01 9.96 1677 476726 142465 70307576
Suicide attempt 207.09 9.96 141 478262 79369 70370672
Irritable bowel syndrome 201.59 9.96 777 477626 50073 70399968
Overdose 200.99 9.96 538 477865 169207 70280834
Sickle cell anaemia with crisis 198.75 9.96 223 478180 5755 70444286
Red blood cell sedimentation rate abnormal 198.69 9.96 417 477986 18886 70431155
Sleep disorder due to general medical condition, insomnia type 194.83 9.96 607 477796 35125 70414916
Depressed level of consciousness 185.82 9.96 189 478214 87242 70362799
Blister 184.50 9.96 1236 477167 99290 70350751
Disease progression 183.64 9.96 499 477904 156173 70293868
Arthritis 181.81 9.96 1208 477195 96772 70353269
Acute kidney injury 173.38 9.96 2210 476193 472414 69977627
Abortion spontaneous 172.26 9.96 479 477924 26000 70424041
Knee arthroplasty 170.94 9.96 565 477838 33736 70416305
Blood pressure fluctuation 165.86 9.96 813 477590 58199 70391842
Pregnancy 164.49 9.96 440 477963 23341 70426700
Bradycardia 161.47 9.96 377 478026 124238 70325803
Osteoarthritis 161.16 9.96 952 477451 73195 70376846
Hip arthroplasty 160.96 9.96 485 477918 27555 70422486
Sedation 160.79 9.96 57 478346 46674 70403367
Respiratory arrest 158.21 9.96 83 478320 53850 70396191
Malignant neoplasm progression 157.18 9.96 369 478034 121370 70328671
Weight increased 156.27 9.96 2398 476005 239933 70210108
Rhabdomyolysis 153.13 9.96 256 478147 95504 70354537
Constipation 150.93 9.96 1039 477364 251399 70198642
Renal failure 132.26 9.96 741 477662 188329 70261712
Infection 128.32 9.96 2066 476337 208719 70241322
Red blood cell sedimentation rate increased 127.50 9.96 558 477845 38084 70411957
Ill-defined disorder 126.88 9.96 715 477688 54026 70396015
Drug dependence 125.89 9.96 47 478356 37274 70412767
Rheumatic fever 124.42 9.96 329 478074 17331 70432710
Drug resistance 124.04 9.96 51 478352 38139 70411902
Drug reaction with eosinophilia and systemic symptoms 122.59 9.96 126 478277 57887 70392154
C-reactive protein increased 120.83 9.96 1208 477195 109309 70340732
Agitation 120.54 9.96 283 478120 93092 70356949
Serotonin syndrome 117.46 9.96 69 478334 42045 70407996
Condition aggravated 116.98 9.96 3741 474662 423894 70026147
Respiratory failure 113.34 9.96 670 477733 168065 70281976
Hypotension 112.95 9.96 1983 476420 402398 70047643
Cardio-respiratory arrest 108.90 9.96 333 478070 100344 70349697
Cardiac failure 108.47 9.96 548 477855 142993 70307048
Pancytopenia 107.80 9.96 1522 476881 149585 70300456
Hepatic failure 106.81 9.96 139 478264 57486 70392555
Blood pressure systolic increased 106.21 9.96 706 477697 56553 70393488
Blood pressure diastolic abnormal 105.35 9.96 285 478118 15219 70434822
Contusion 105.15 9.96 1323 477080 126713 70323328
Hepatic function abnormal 103.94 9.96 187 478216 67809 70382232
Joint effusion 102.67 9.96 282 478121 15195 70434846
Swollen joint count increased 102.44 9.96 261 478142 13439 70436602
Electrocardiogram QT prolonged 100.85 9.96 262 478141 83255 70366786
Somnolence 100.44 9.96 949 477454 214657 70235384
Osteoporosis 99.30 9.96 617 477786 48290 70401751
Enthesopathy 98.42 9.96 223 478180 10646 70439395
Multiple organ dysfunction syndrome 97.16 9.96 389 478014 108126 70341915
Intentional self-injury 96.90 9.96 46 478357 31604 70418437
Neutropenia 96.83 9.96 1189 477214 255967 70194074
Fibromyalgia 96.60 9.96 603 477800 47271 70402770
Plasma cell myeloma 95.97 9.96 220 478183 72981 70377060
Inflammation 94.43 9.96 877 477526 77788 70372253
Foot deformity 93.93 9.96 330 478073 20325 70429716
Live birth 93.33 9.96 253 478150 13526 70436515
Hypoglycaemia 93.14 9.96 325 478078 94039 70356002
Drug ineffective 92.70 9.96 7445 470958 932307 69517734
Blood pressure systolic abnormal 92.48 9.96 242 478161 12667 70437374
Lactic acidosis 92.24 9.96 187 478216 64837 70385204
Coma 91.54 9.96 315 478088 91529 70358512
Rheumatoid nodule 90.64 9.96 265 478138 14802 70435239
Cardiac failure congestive 89.82 9.96 540 477863 134917 70315124
Hypoxia 89.78 9.96 325 478078 93019 70357022
Grip strength decreased 89.73 9.96 271 478132 15414 70434627
Stomatitis 89.09 9.96 1288 477115 127223 70322818
Neuropathy peripheral 87.80 9.96 499 477904 126397 70323644
Caesarean section 86.66 9.96 221 478182 11386 70438655
Intentional product misuse 86.27 9.96 263 478140 79332 70370709
Hyperglycaemia 85.89 9.96 193 478210 64479 70385562
Device expulsion 85.83 9.96 22 478381 22224 70427817
Rash 85.74 9.96 4237 474166 506325 69943716
Cytomegalovirus infection 84.39 9.96 86 478317 39672 70410369
Poisoning 84.21 9.96 24 478379 22598 70427443
Palmar-plantar erythrodysaesthesia syndrome 83.73 9.96 50 478353 30197 70419844
Injection site erythema 83.05 9.96 804 477599 72120 70377921
Drug withdrawal syndrome 82.55 9.96 60 478343 32655 70417386
Musculoskeletal pain 81.40 9.96 950 477453 89377 70360664
Hyperhidrosis 80.85 9.96 537 477866 131049 70318992
Product use in unapproved indication 80.49 9.96 953 477450 206525 70243516
Tenosynovitis 80.45 9.96 242 478161 13734 70436307
Blood pressure diastolic decreased 80.32 9.96 366 478037 25414 70424627
Neoplasm progression 79.87 9.96 113 478290 45115 70404926
Renal impairment 79.38 9.96 606 477797 143331 70306710
Sopor 79.34 9.96 57 478346 31210 70418831
Respiratory depression 79.29 9.96 34 478369 24797 70425244
Disability assessment scale score increased 79.19 9.96 99 478304 2872 70447169
Gastrointestinal disorder 78.85 9.96 1071 477332 104356 70345685
Injection site pruritus 77.94 9.96 492 477911 38718 70411323
Basal cell carcinoma 76.66 9.96 438 477965 33260 70416781
Blood creatine phosphokinase increased 74.87 9.96 191 478212 61072 70388969
Bone erosion 74.76 9.96 249 478154 14924 70435117
Tachycardia 73.74 9.96 698 477705 157848 70292193
Hyponatraemia 72.67 9.96 709 477694 159378 70290663
Joint stiffness 72.18 9.96 445 477958 34731 70415310
Syncope 71.86 9.96 742 477661 164967 70285074
Sedation complication 70.98 9.96 5 478398 13405 70436636
Anxiety 70.53 9.96 1053 477350 219277 70230764
Polyarthritis 69.38 9.96 194 478209 10562 70439479
Tremor 69.07 9.96 693 477710 154931 70295110
Myalgia 68.68 9.96 762 477641 167130 70282911
Pulmonary arterial hypertension 68.68 9.96 72 478331 32783 70417258
Angioedema 67.36 9.96 227 478176 66383 70383658
Fatigue 67.21 9.96 6441 471962 817878 69632163
Acute hepatic failure 66.94 9.96 53 478350 27619 70422422
Myocardial infarction 66.71 9.96 788 477615 170857 70279184
Shock 66.54 9.96 106 478297 40319 70409722
Neuroleptic malignant syndrome 66.53 9.96 47 478356 25960 70424081
Pain in extremity 66.35 9.96 2775 475628 325307 70124734
Nausea 66.20 9.96 4902 473501 847186 69602855
Seizure 65.75 9.96 826 477577 177136 70272905
Joint laxity 65.66 9.96 80 478323 2259 70447782
Heart rate decreased 65.42 9.96 673 477730 61342 70388699
Injection site reaction 64.53 9.96 565 477838 49287 70400754
Psoriasis 64.46 9.96 977 477426 97456 70352585
Juvenile idiopathic arthritis 62.86 9.96 128 478275 5672 70444369
Mental status changes 62.48 9.96 217 478186 62884 70387157
Joint range of motion decreased 62.33 9.96 343 478060 25683 70424358
Altered state of consciousness 61.22 9.96 110 478293 39912 70410129
Asthma 59.54 9.96 524 477879 120269 70329772
Joint destruction 58.93 9.96 110 478293 4568 70445473
Unresponsive to stimuli 58.87 9.96 168 478235 51763 70398278
Pulmonary fibrosis 58.84 9.96 415 477988 33895 70416146
Loss of personal independence in daily activities 58.82 9.96 851 477552 84059 70365982
Hallucination 58.81 9.96 289 478114 75971 70374070
Neutrophil count decreased 58.63 9.96 327 478076 83229 70366812
Premature delivery 58.06 9.96 291 478112 21013 70429028
Localised infection 58.00 9.96 403 478000 32755 70417286
General physical health deterioration 57.30 9.96 2037 476366 233994 70216047
Mydriasis 56.78 9.96 19 478384 16134 70433907
Vomiting 56.63 9.96 3349 475054 589762 69860279
Diabetic ketoacidosis 56.37 9.96 78 478325 31434 70418607
Drug ineffective for unapproved indication 56.23 9.96 109 478294 38429 70411612
Immune reconstitution inflammatory syndrome 55.92 9.96 10 478393 12980 70437061
Injection site swelling 55.79 9.96 489 477914 42668 70407373
Cognitive disorder 55.51 9.96 217 478186 60739 70389302
Infective pulmonary exacerbation of cystic fibrosis 55.39 9.96 8 478395 12150 70437891
Abnormal behaviour 55.27 9.96 93 478310 34616 70415425
Neurotoxicity 55.21 9.96 72 478331 29754 70420287
Blood cholesterol increased 54.91 9.96 672 477731 63932 70386109
Blood glucose increased 54.70 9.96 438 477965 102544 70347497
Disseminated intravascular coagulation 54.45 9.96 89 478314 33509 70416532
Pre-eclampsia 54.27 9.96 129 478274 6356 70443685
Latent tuberculosis 53.30 9.96 84 478319 3037 70447004
Femur fracture 52.89 9.96 421 477982 35711 70414330
Fracture 52.65 9.96 270 478133 19674 70430367
Maternal exposure before pregnancy 52.21 9.96 93 478310 3723 70446318
Premature rupture of membranes 52.06 9.96 94 478309 3804 70446237
Nodule 51.79 9.96 269 478134 19700 70430341
Ventricular tachycardia 51.44 9.96 105 478298 36318 70413723
Multiple sclerosis relapse 51.12 9.96 136 478267 42881 70407160
Injection site pain 50.99 9.96 1094 477309 116525 70333516
Tongue disorder 50.68 9.96 200 478203 13027 70437014
Ventricular fibrillation 50.64 9.96 65 478338 27046 70422995
Skin ulcer 50.55 9.96 522 477881 47623 70402418
Depression 50.37 9.96 992 477411 197982 70252059
Premature labour 50.34 9.96 143 478260 7857 70442184
Post transplant lymphoproliferative disorder 50.29 9.96 6 478397 10539 70439502
Orthostatic hypotension 49.85 9.96 180 478223 51563 70398478
Tendonitis 49.31 9.96 286 478117 21836 70428205
Disability 49.14 9.96 216 478187 14767 70435274
Foetal exposure during pregnancy 49.10 9.96 114 478289 5531 70444510
Balance disorder 48.95 9.96 381 478022 89747 70360294
Dyspnoea 48.94 9.96 4501 473902 765559 69684482
Dizziness 48.60 9.96 2597 475806 461544 69988497
Substance abuse 48.43 9.96 5 478398 9832 70440209
Intentional product use issue 48.14 9.96 1105 477298 119037 70331004
Red blood cell sedimentation rate 48.13 9.96 104 478299 4806 70445235
Blood pressure diastolic increased 48.00 9.96 188 478215 12203 70437838
Pathogen resistance 47.77 9.96 15 478388 13264 70436777
Diarrhoea 47.73 9.96 4593 473810 778748 69671293
Cardiogenic shock 47.68 9.96 109 478294 36198 70413843
Suicidal ideation 47.41 9.96 275 478128 69321 70380720
Speech disorder 47.39 9.96 178 478225 50402 70399639
Metabolic acidosis 47.38 9.96 300 478103 74046 70375995
Herpes zoster 47.22 9.96 823 477580 84412 70365629
Synovial cyst 47.18 9.96 148 478255 8594 70441447
Body temperature decreased 46.96 9.96 343 478060 28329 70421712
Laryngitis 46.61 9.96 199 478204 13432 70436609
Psychotic disorder 46.48 9.96 117 478286 37584 70412457
Aspergillus infection 46.09 9.96 32 478371 17836 70432205
Fluid retention 45.60 9.96 246 478157 63139 70386902
Irritability 45.31 9.96 121 478282 38104 70411937
Blood pressure increased 45.01 9.96 1624 476779 186893 70263148
Product quality issue 44.97 9.96 86 478317 30475 70419566
Alanine aminotransferase abnormal 44.94 9.96 138 478265 7921 70442120
Delirium 44.56 9.96 307 478096 74307 70375734
Encephalopathy 43.98 9.96 240 478163 61421 70388620
Multiple fractures 43.62 9.96 122 478281 6643 70443398
Torsade de pointes 43.44 9.96 35 478368 18081 70431960
Ascites 42.82 9.96 273 478130 67274 70382767
Creatinine renal clearance decreased 42.81 9.96 32 478371 17168 70432873
Drug level increased 42.80 9.96 116 478287 36353 70413688
Tuberculosis 42.73 9.96 206 478197 14642 70435399
Atrial fibrillation 42.26 9.96 934 477469 183414 70266627
Ear infection 41.93 9.96 331 478072 28005 70422036
Brain oedema 41.86 9.96 58 478345 23360 70426681
No adverse event 41.84 9.96 97 478306 32056 70417985
Anaphylactic shock 41.49 9.96 99 478304 32391 70417650
Urticaria 41.22 9.96 813 477590 162236 70287805
Neck deformity 41.18 9.96 55 478348 1706 70448335
Cerebrovascular accident 41.08 9.96 700 477703 142770 70307271
Vision blurred 40.87 9.96 426 477977 94558 70355483
Foetal death 40.71 9.96 113 478290 6126 70443915
Akathisia 40.60 9.96 16 478387 12277 70437764
Drug use disorder 40.50 9.96 4 478399 8147 70441894
Venoocclusive liver disease 40.36 9.96 11 478392 10667 70439374
Asthenia 40.33 9.96 2603 475800 455063 69994978
Injection site bruising 40.23 9.96 413 477990 37619 70412422
Transplant rejection 40.07 9.96 38 478365 18133 70431908
Respiratory distress 39.92 9.96 211 478192 54439 70395602
Tenderness 39.61 9.96 262 478141 20948 70429093
White blood cell count decreased 39.58 9.96 860 477543 169281 70280760
Oropharyngeal pain 39.26 9.96 888 477515 95422 70354619
Hypothermia 38.86 9.96 49 478354 20545 70429496
Extrapyramidal disorder 38.50 9.96 50 478353 20700 70429341
Asphyxia 38.44 9.96 11 478392 10331 70439710
Restlessness 38.34 9.96 150 478253 41978 70408063
Disorientation 38.32 9.96 231 478172 57692 70392349
Coronary artery disease 37.53 9.96 258 478145 62478 70387563
Emotional distress 37.41 9.96 127 478276 37061 70412980
Blood creatinine increased 37.38 9.96 709 477694 142292 70307749
Graft versus host disease 37.32 9.96 28 478375 14995 70435046
Mouth ulceration 37.29 9.96 375 478028 33974 70416067
Mucormycosis 37.15 9.96 5 478398 8009 70442032
Limb deformity 37.00 9.96 76 478327 3389 70446652
Bursitis 36.99 9.96 307 478096 26366 70423675
Withdrawal syndrome 36.71 9.96 70 478333 24834 70425207
Dehydration 36.38 9.96 1205 477198 224937 70225104
Pulmonary oedema 36.23 9.96 367 478036 81911 70368130
Haematotoxicity 35.93 9.96 24 478379 13650 70436391
Platelet count decreased 35.86 9.96 921 477482 177301 70272740
Disturbance in attention 35.76 9.96 158 478245 42736 70407305
Second primary malignancy 35.53 9.96 22 478381 13029 70437012
Colorectal cancer 35.44 9.96 7 478396 8463 70441578
Forced expiratory volume decreased 35.29 9.96 4 478399 7310 70442731
Wrong technique in product usage process 35.19 9.96 295 478108 68403 70381638
Injection site rash 35.19 9.96 210 478193 16200 70433841
Mobility decreased 35.17 9.96 927 477476 102072 70347969
Cytokine release syndrome 35.12 9.96 79 478324 26388 70423653
Dystonia 35.03 9.96 49 478354 19657 70430384
Proteinuria 34.80 9.96 93 478310 29281 70420760
BK virus infection 34.72 9.96 6 478397 7983 70442058
Coagulopathy 34.51 9.96 112 478291 33137 70416904
Joint dislocation 34.46 9.96 191 478212 14340 70435701
Sepsis 34.34 9.96 1325 477078 243220 70206821
Tumour lysis syndrome 34.23 9.96 57 478346 21303 70428738
Gastrointestinal haemorrhage 34.17 9.96 687 477716 136721 70313320
Unintentional medical device removal 34.11 9.96 4 478399 7120 70442921
Lupus-like syndrome 34.04 9.96 161 478242 11354 70438687
Arrhythmia 34.02 9.96 230 478173 55913 70394128
Bronchitis 33.86 9.96 1033 477370 116210 70333831
Type 2 diabetes mellitus 33.85 9.96 450 477953 43630 70406411
Fear 33.84 9.96 55 478348 20756 70429285
Therapeutic response decreased 33.68 9.96 568 477835 57885 70392156
Neck mass 33.67 9.96 82 478321 4104 70445937
Mania 33.31 9.96 40 478363 17134 70432907
Pulmonary hypertension 33.26 9.96 181 478222 46355 70403686
Maternal exposure timing unspecified 33.19 9.96 84 478319 4307 70445734
Poor venous access 33.01 9.96 193 478210 14778 70435263
Inappropriate antidiuretic hormone secretion 32.95 9.96 67 478336 23209 70426832
Haemorrhage intracranial 32.84 9.96 74 478329 24703 70425338
Aggression 32.69 9.96 192 478211 48254 70401787
Cerebral infarction 32.57 9.96 164 478239 42845 70407196
Arthritis infective 32.48 9.96 117 478286 7295 70442746
Cerebral haemorrhage 32.47 9.96 221 478182 53643 70396398
Skin papilloma 32.44 9.96 95 478308 5311 70444730
Fear of injection 32.43 9.96 109 478294 6563 70443478
Adverse event 32.39 9.96 491 477912 48970 70401071
Oral herpes 32.28 9.96 276 478127 23910 70426131
Smear cervix abnormal 32.28 9.96 58 478345 2338 70447703
Immunodeficiency 32.27 9.96 216 478187 17339 70432702
Joint injury 32.17 9.96 300 478103 26632 70423409
Blood parathyroid hormone decreased 31.84 9.96 133 478270 8891 70441150
Malignant melanoma 31.83 9.96 181 478222 13719 70436322
Myoclonus 31.56 9.96 83 478320 26272 70423769
Loss of consciousness 31.51 9.96 804 477599 154912 70295129
Leukocytosis 31.35 9.96 149 478254 39519 70410522
Flushing 31.23 9.96 379 478024 81793 70368248
Toxic epidermal necrolysis 31.02 9.96 149 478254 39408 70410633
Muscle spasms 31 9.96 796 477607 153250 70296791
Dysarthria 30.83 9.96 270 478133 62043 70387998
Wheelchair user 30.69 9.96 91 478312 5123 70444918
Posterior reversible encephalopathy syndrome 30.65 9.96 75 478328 24327 70425714
Granuloma skin 30.12 9.96 117 478286 7565 70442476
Decreased appetite 29.70 9.96 1717 476686 303063 70146978
Ejection fraction decreased 29.64 9.96 107 478296 30655 70419386
Tenosynovitis stenosans 29.56 9.96 55 478348 2278 70447763
Chest discomfort 29.41 9.96 627 477776 123754 70326287
Ulcer 29.34 9.96 284 478119 25470 70424571
Exostosis 29.13 9.96 181 478222 14164 70435877
Paradoxical drug reaction 28.80 9.96 5 478398 6631 70443410
Status epilepticus 28.79 9.96 78 478325 24448 70425593
Muscle rigidity 28.76 9.96 51 478352 18599 70431442
Small for dates baby 28.71 9.96 24 478379 425 70449616
Tachypnoea 28.67 9.96 98 478305 28540 70421501
Pulmonary embolism 28.61 9.96 816 477587 155051 70294990
Spinal stenosis 28.58 9.96 183 478220 14470 70435571
Blood bilirubin increased 28.57 9.96 262 478141 59639 70390402
Anaphylactic reaction 28.42 9.96 346 478057 74628 70375413
Dyskinesia 28.13 9.96 162 478241 40912 70409129
Thrombocytopenia 28.03 9.96 1322 477081 237788 70212253
Haemorrhage 28.03 9.96 397 478006 83418 70366623
Potentiating drug interaction 28.01 9.96 10 478393 8154 70441887
Dysgeusia 27.94 9.96 207 478196 49295 70400746
Psychomotor hyperactivity 27.81 9.96 38 478365 15395 70434646
Polyhydramnios 27.78 9.96 42 478361 1464 70448577
Appendicolith 27.67 9.96 3 478400 5677 70444364
Acute graft versus host disease 27.62 9.96 15 478388 9547 70440494
Skin cancer 27.61 9.96 171 478232 13365 70436676
Chronic kidney disease 27.44 9.96 271 478132 60786 70389255
Foot fracture 27.40 9.96 226 478177 19374 70430667
Joint noise 27.37 9.96 67 478336 3364 70446677
Glycosylated haemoglobin increased 27.32 9.96 47 478356 17344 70432697
Pain in jaw 27.27 9.96 172 478231 42497 70407544
Miosis 27.18 9.96 33 478370 14068 70435973
Acute chest syndrome 27.16 9.96 33 478370 929 70449112
Bronchospasm 27.12 9.96 72 478331 22720 70427321
Panniculitis 27.12 9.96 143 478260 10533 70439508
Bronchopulmonary aspergillosis 26.81 9.96 64 478339 20938 70429103
Aphthous ulcer 26.74 9.96 180 478223 14476 70435565
Hypokalaemia 26.63 9.96 677 477726 130511 70319530
Stevens-Johnson syndrome 26.58 9.96 138 478265 35769 70414272
Pneumatosis intestinalis 26.53 9.96 4 478399 5883 70444158
Endophthalmitis 26.53 9.96 5 478398 6250 70443791
Thrombotic microangiopathy 26.46 9.96 50 478353 17798 70432243
Pulmonary tuberculosis 26.42 9.96 114 478289 7731 70442310
Normal newborn 26.39 9.96 98 478305 6202 70443839
Haemoptysis 26.32 9.96 221 478182 51231 70398810
Product administration error 26.30 9.96 106 478297 29417 70420624
Rotator cuff repair 26.23 9.96 43 478360 1608 70448433
Synovial fluid analysis 26.15 9.96 46 478357 1823 70448218
Gastroenteritis viral 26.14 9.96 240 478163 21215 70428826
Respiration abnormal 26.07 9.96 7 478396 6857 70443184
Device difficult to use 25.96 9.96 21 478382 10828 70439213
Muscle spasticity 25.94 9.96 59 478344 19630 70430411
Adenovirus infection 25.83 9.96 10 478393 7758 70442283
Retinitis 25.82 9.96 74 478329 4086 70445955
Abortion late 25.76 9.96 12 478391 68 70449973
Bone disorder 25.71 9.96 204 478199 17286 70432755
Blood pressure decreased 25.71 9.96 448 477955 91067 70358974
Feeling abnormal 25.63 9.96 747 477656 141572 70308469
Lip dry 25.50 9.96 132 478271 9653 70440388
Acidosis 25.49 9.96 53 478350 18210 70431831
Loose body in joint 25.46 9.96 37 478366 1244 70448797
Fracture delayed union 25.42 9.96 48 478355 2011 70448030
Tardive dyskinesia 25.32 9.96 18 478385 9911 70440130
Hyperkalaemia 25.29 9.96 537 477866 106054 70343987
Immunosuppression 25.24 9.96 148 478255 11344 70438697
Device use error 25.11 9.96 7 478396 6689 70443352
Folate deficiency 25.06 9.96 60 478343 2970 70447071
Scleritis 25.03 9.96 67 478336 3555 70446486
Peripheral venous disease 25.02 9.96 140 478263 10547 70439494
Klebsiella infection 24.94 9.96 36 478367 14256 70435785
Cyanosis 24.91 9.96 77 478326 23129 70426912
Respiratory disorder 24.85 9.96 158 478245 38965 70411076
Schizophrenia 24.83 9.96 47 478356 16721 70433320
Blood alkaline phosphatase increased 24.55 9.96 264 478139 58257 70391784
Subdural haematoma 24.37 9.96 108 478295 29190 70420851
Nocardiosis 24.26 9.96 3 478400 5126 70444915
Metastases to bone 24.19 9.96 74 478329 22302 70427739
Nightmare 24.15 9.96 73 478330 22083 70427958
Exposure to toxic agent 24.14 9.96 6 478397 6188 70443853
Cystitis haemorrhagic 24.07 9.96 14 478389 8579 70441462
Chest pain 24.01 9.96 1418 476985 249842 70200199
Abortion threatened 23.99 9.96 21 478382 397 70449644
Stillbirth 23.93 9.96 68 478335 3737 70446304
Foetal distress syndrome 23.87 9.96 22 478381 446 70449595
Dactylitis 23.87 9.96 49 478354 2184 70447857
Drug hypersensitivity 23.71 9.96 1489 476914 260970 70189071
International normalised ratio increased 23.71 9.96 392 478011 80334 70369707
Incorrect route of product administration 23.68 9.96 95 478308 26397 70423644
Sinus tachycardia 23.63 9.96 133 478270 33780 70416261
Aphasia 23.39 9.96 183 478220 43066 70406975
Cardiac failure acute 23.36 9.96 52 478351 17435 70432606
Delusion 23.22 9.96 60 478343 19105 70430936
Erythema multiforme 23.18 9.96 48 478355 16516 70433525
Post procedural infection 23.17 9.96 134 478269 10219 70439822
Pancreatitis 23.07 9.96 291 478112 62377 70387664
Facet joint syndrome 23.07 9.96 92 478311 6021 70444020
Pleural effusion 23.02 9.96 701 477702 132163 70317878
Clostridium difficile colitis 22.86 9.96 109 478294 28887 70421154
Anuria 22.70 9.96 63 478340 19590 70430451
Palpitations 22.62 9.96 571 477832 110182 70339859
Pulmonary congestion 22.61 9.96 90 478313 25064 70424977
Lethargy 22.56 9.96 364 478039 74886 70375155
Acute respiratory failure 22.55 9.96 242 478161 53423 70396618
Angina pectoris 22.48 9.96 213 478190 48170 70401871
Anaemia macrocytic 22.27 9.96 81 478322 5074 70444967
Antinuclear antibody positive 22.02 9.96 98 478305 6735 70443306
Hypervolaemia 21.95 9.96 167 478236 39539 70410502
Injection site warmth 21.85 9.96 164 478239 13661 70436380
Cytomegalovirus viraemia 21.84 9.96 28 478375 11657 70438384
Bone pain 21.83 9.96 228 478175 50594 70399447
Dermatitis acneiform 21.80 9.96 17 478386 8928 70441113
Cholestasis 21.71 9.96 212 478191 47660 70402381
Bradyphrenia 21.70 9.96 21 478382 9925 70440116
Acute respiratory distress syndrome 21.65 9.96 176 478227 41078 70408963
Haemorrhage in pregnancy 21.60 9.96 35 478368 1296 70448745
Aspartate aminotransferase increased 21.50 9.96 672 477731 126306 70323735
Breast feeding 21.48 9.96 25 478378 672 70449369
Respiratory disorder neonatal 21.42 9.96 10 478393 57 70449984
Dyspnoea exertional 21.37 9.96 386 478017 78044 70371997
Disease recurrence 21.34 9.96 157 478246 37446 70412595
Blood calcium decreased 21.27 9.96 111 478292 28735 70421306
Accidental overdose 21.22 9.96 144 478259 34977 70415064
Dislocation of vertebra 21.18 9.96 77 478326 4823 70445218
Placental disorder 21.12 9.96 28 478375 862 70449179
Lymphocyte count decreased 20.95 9.96 190 478213 43349 70406692
Dysmorphism 20.94 9.96 22 478381 526 70449515
Hypomagnesaemia 20.89 9.96 175 478228 40589 70409452
Sciatica 20.85 9.96 256 478147 24371 70425670
Anger 20.72 9.96 49 478354 16083 70433958
Synovial disorder 20.68 9.96 31 478372 1072 70448969
Renal injury 20.58 9.96 49 478354 16045 70433996
Induced labour 20.57 9.96 27 478376 823 70449218
Oligohydramnios 20.47 9.96 58 478345 3182 70446859
Pseudomonas infection 20.40 9.96 63 478340 18931 70431110
Polyuria 20.36 9.96 37 478366 13369 70436672
Compartment syndrome 20.33 9.96 3 478400 4483 70445558
Pulmonary alveolar haemorrhage 20.27 9.96 24 478379 10345 70439696
Atrioventricular block 20.20 9.96 34 478369 12654 70437387
Sexual dysfunction 20.01 9.96 10 478393 6671 70443370
Rheumatoid lung 20.01 9.96 60 478343 3399 70446642
Speech disorder developmental 20.00 9.96 23 478380 610 70449431
Malignant mediastinal neoplasm 19.96 9.96 27 478376 848 70449193
Placental insufficiency 19.94 9.96 30 478373 1041 70449000
Hyperammonaemia 19.93 9.96 24 478379 10269 70439772
Electrocardiogram QRS complex prolonged 19.93 9.96 22 478381 9784 70440257
Melaena 19.89 9.96 264 478139 56091 70393950
Jaundice 19.85 9.96 229 478174 49879 70400162
Anti-cyclic citrullinated peptide antibody 19.85 9.96 59 478344 3326 70446715
Right ventricular failure 19.83 9.96 80 478323 22194 70427847
Insomnia 19.78 9.96 1235 477168 216571 70233470
Muscle twitching 19.75 9.96 68 478335 19759 70430282
Coordination abnormal 19.69 9.96 50 478353 16016 70434025
Anal fistula 19.67 9.96 87 478316 5963 70444078
Cytopenia 19.66 9.96 56 478347 17267 70432774
Acute myeloid leukaemia 19.63 9.96 125 478278 30815 70419226
Pulseless electrical activity 19.61 9.96 37 478366 13178 70436863
Hyperlactacidaemia 19.60 9.96 5 478398 5067 70444974
Off label use 19.54 9.96 4578 473825 738482 69711559
Hallucination, auditory 19.54 9.96 61 478342 18267 70431774
Myelosuppression 19.53 9.96 121 478282 30024 70420017
Low birth weight baby 19.51 9.96 22 478381 571 70449470
Dysphagia 19.38 9.96 596 477807 112238 70337803
Drug tolerance decreased 19.30 9.96 123 478280 9710 70440331
Hospitalisation 19.29 9.96 417 477986 82151 70367890
Diabetes insipidus 19.25 9.96 4 478399 4667 70445374
Oliguria 19.11 9.96 46 478357 15005 70435036
Influenza 19.07 9.96 944 477459 112756 70337285
Cushingoid 19.06 9.96 109 478294 8279 70441762
Pulmonary haemorrhage 18.81 9.96 40 478363 13633 70436408
Bacteraemia 18.81 9.96 118 478285 29191 70420850
Sinus bradycardia 18.51 9.96 89 478314 23534 70426507
Pemphigoid 18.49 9.96 42 478361 13980 70436061
Breast cancer stage I 18.48 9.96 9 478394 6093 70443948
Fine motor skill dysfunction 18.47 9.96 75 478328 4949 70445092
Lip swelling 18.46 9.96 144 478259 33910 70416131
Anhedonia 18.39 9.96 43 478360 14170 70435871
Erectile dysfunction 18.39 9.96 40 478363 13522 70436519
Unevaluable event 18.34 9.96 244 478159 51819 70398222
Febrile bone marrow aplasia 18.30 9.96 33 478370 11958 70438083
Gastric haemorrhage 18.29 9.96 43 478360 14142 70435899
Multiple sclerosis 18.26 9.96 98 478305 25187 70424854
Cardiotoxicity 18.24 9.96 29 478374 11041 70439000
Deep vein thrombosis 18.24 9.96 590 477813 110452 70339589
Surgery 18.23 9.96 294 478109 29695 70420346
Hepatic encephalopathy 18.11 9.96 82 478321 22036 70428005
Paranoia 18.10 9.96 58 478345 17230 70432811
Adjustment disorder with depressed mood 17.95 9.96 66 478337 4157 70445884
Ingrown hair 17.82 9.96 22 478381 630 70449411
Pharyngitis streptococcal 17.82 9.96 117 478286 9331 70440710
Foetal anticonvulsant syndrome 17.77 9.96 14 478389 227 70449814
Metastases to liver 17.76 9.96 102 478301 25776 70424265
Paralysis 17.73 9.96 34 478369 12038 70438003
Endodontic procedure 17.60 9.96 47 478356 2490 70447551
End stage renal disease 17.57 9.96 30 478373 11103 70438938
Frequent bowel movements 17.52 9.96 219 478184 20934 70429107
Human antichimeric antibody positive 17.49 9.96 34 478369 1456 70448585
Haematocrit decreased 17.47 9.96 508 477895 56750 70393291
Arthritis bacterial 17.42 9.96 105 478298 8128 70441913
Wound infection 17.38 9.96 188 478215 17354 70432687
Rhinorrhoea 17.38 9.96 578 477825 65793 70384248
Abortion missed 17.38 9.96 30 478373 1171 70448870
Oxygen saturation decreased 17.37 9.96 956 477447 115473 70334568
Coronary arterial stent insertion 17.35 9.96 9 478394 5878 70444163
Memory impairment 17.25 9.96 484 477919 92157 70357884
Drug abuser 17.23 9.96 9 478394 5855 70444186
Osteonecrosis of jaw 17.18 9.96 185 478218 40817 70409224
COVID-19 17.11 9.96 563 477840 105194 70344847
Myopathy 17.11 9.96 66 478337 18546 70431495
Drug screen positive 17.10 9.96 9 478394 5831 70444210
Postoperative wound infection 17.08 9.96 133 478270 11205 70438836
Dyslipidaemia 17.05 9.96 25 478378 9835 70440206
Hepatotoxicity 17.04 9.96 202 478201 43784 70406257
Peripheral sensory neuropathy 17.02 9.96 35 478368 12075 70437966
Accidental exposure to product 16.95 9.96 115 478288 27936 70422105
Blood lactic acid increased 16.83 9.96 31 478372 11142 70438899
Bronchial carcinoma 16.77 9.96 30 478373 1205 70448836
Tuberculin test positive 16.65 9.96 54 478349 3192 70446849
Axonal neuropathy 16.62 9.96 39 478364 1905 70448136
Bradypnoea 16.61 9.96 8 478395 5451 70444590
Lower respiratory tract congestion 16.58 9.96 55 478348 3289 70446752
Tubulointerstitial nephritis 16.50 9.96 143 478260 32933 70417108
Progressive multifocal leukoencephalopathy 16.49 9.96 70 478333 19144 70430897
Polydipsia 16.43 9.96 10 478393 5978 70444063
Spinal osteoarthritis 16.39 9.96 167 478236 15181 70434860
Alanine aminotransferase increased 16.37 9.96 820 477583 146660 70303381
Oesophageal fibrosis 16.35 9.96 12 478391 174 70449867
Rebound effect 16.34 9.96 10 478393 5961 70444080
Breast cancer metastatic 16.33 9.96 27 478376 10119 70439922
Alcohol abuse 16.29 9.96 7 478396 5100 70444941
Sickle cell anaemia 16.15 9.96 21 478382 634 70449407
Stress cardiomyopathy 16.10 9.96 26 478377 9836 70440205
Twin pregnancy 16.08 9.96 24 478379 827 70449214
Lipase increased 16.07 9.96 51 478352 15195 70434846
Hepatitis B reactivation 16.06 9.96 8 478395 5347 70444694
Metastases to central nervous system 16.05 9.96 50 478353 14984 70435057
Bronchioloalveolar carcinoma 16.03 9.96 8 478395 54 70449987
Temperature regulation disorder 16.02 9.96 5 478398 4439 70445602
Graft versus host disease in skin 16.02 9.96 9 478394 5621 70444420
Respiratory acidosis 15.95 9.96 28 478375 10253 70439788
Complication of device insertion 15.94 9.96 8 478395 5324 70444717
Cardiac failure chronic 15.91 9.96 28 478375 10241 70439800
Ileus 15.85 9.96 97 478306 24140 70425901
Musculoskeletal disorder 15.80 9.96 205 478198 19766 70430275
Lacrimal disorder 15.78 9.96 18 478385 473 70449568
Cytomegalovirus chorioretinitis 15.76 9.96 8 478395 5290 70444751
Device leakage 15.70 9.96 24 478379 9284 70440757
Red blood cell count decreased 15.70 9.96 462 477941 51699 70398342
Blood glucose decreased 15.64 9.96 97 478306 24062 70425979
Pneumothorax 15.60 9.96 106 478297 25740 70424301
Hyperthyroidism 15.56 9.96 76 478327 20015 70430026
Hydrops foetalis 15.56 9.96 13 478390 230 70449811
Nephropathy toxic 15.55 9.96 68 478335 18446 70431595
Heparin-induced thrombocytopenia 15.54 9.96 23 478380 9014 70441027
Acute coronary syndrome 15.53 9.96 76 478327 20003 70430038
Mental disorder 15.50 9.96 119 478284 28121 70421920
Abdominal distension 15.36 9.96 564 477839 104105 70345936
Skin exfoliation 15.32 9.96 233 478170 48393 70401648
Haemophagocytic lymphohistiocytosis 15.30 9.96 74 478329 19538 70430503
Hemiparesis 15.28 9.96 137 478266 31332 70418709
Panic attack 15.27 9.96 87 478316 22032 70428009
Onychomycosis 15.24 9.96 89 478314 6812 70443229
Tooth abscess 15.23 9.96 158 478245 14431 70435610
Lung disorder 15.22 9.96 593 477810 68891 70381150
Acute lymphocytic leukaemia recurrent 15.21 9.96 7 478396 4897 70445144
Lung transplant 15.16 9.96 5 478398 4285 70445756
Body height below normal 15.11 9.96 37 478366 1858 70448183
Cholestasis of pregnancy 15.08 9.96 25 478378 944 70449097
Cardiomyopathy 15.02 9.96 110 478293 26263 70423778
Ankle arthroplasty 15.01 9.96 28 478375 1162 70448879
Hepatic cirrhosis 15.01 9.96 291 478112 30440 70419601
Mycobacterium tuberculosis complex test positive 14.97 9.96 42 478361 2291 70447750
Affective disorder 14.96 9.96 17 478386 7462 70442579
Anaemia folate deficiency 14.95 9.96 14 478389 290 70449751
Hypophosphataemia 14.94 9.96 58 478345 16268 70433773
Spinal disorder 14.93 9.96 110 478293 9110 70440931
Haematoma 14.92 9.96 233 478170 48185 70401856
Pleuritic pain 14.89 9.96 107 478296 8790 70441251
Hepatitis C 14.83 9.96 41 478362 12766 70437275
Accidental death 14.82 9.96 4 478399 3904 70446137
Amylase increased 14.78 9.96 29 478374 10179 70439862
Tonsillitis 14.75 9.96 81 478322 6059 70443982
Haemodynamic instability 14.73 9.96 55 478348 15603 70434438
Myocarditis 14.61 9.96 71 478332 18722 70431319
Uterine perforation 14.61 9.96 11 478392 5880 70444161
Transplant dysfunction 14.60 9.96 15 478388 6894 70443147
Breast cancer stage II 14.57 9.96 9 478394 5337 70444704
Acute generalised exanthematous pustulosis 14.54 9.96 54 478349 15343 70434698
Acute graft versus host disease in skin 14.52 9.96 16 478387 7121 70442920
Peritoneal dialysis complication 14.41 9.96 41 478362 2255 70447786
Multiple-drug resistance 14.40 9.96 17 478386 7338 70442703
Ventricular arrhythmia 14.39 9.96 19 478384 7811 70442230
Polyneuropathy 14.38 9.96 85 478318 21330 70428711
Obstructive airways disorder 14.35 9.96 110 478293 26003 70424038
Hyperlipidaemia 14.34 9.96 98 478305 23765 70426276
Lymphatic fistula 14.32 9.96 22 478381 778 70449263
Obesity 14.29 9.96 257 478146 26514 70423527
Gamma-glutamyltransferase increased 14.27 9.96 248 478155 50437 70399604
Genital haemorrhage 14.24 9.96 11 478392 5804 70444237
Myocardial ischaemia 14.23 9.96 100 478303 24100 70425941
Hypertransaminasaemia 14.20 9.96 24 478379 8919 70441122
Deep vein thrombosis postoperative 14.19 9.96 55 478348 3552 70446489
Metastases to lung 14.18 9.96 60 478343 16424 70433617
Renal disorder 14.18 9.96 176 478227 37833 70412208
Femoral hernia incarcerated 14.17 9.96 22 478381 785 70449256
Hypospadias 14.16 9.96 10 478393 136 70449905
Hyperprolactinaemia 14.16 9.96 6 478397 4407 70445634
Skin necrosis 14.07 9.96 170 478233 16121 70433920
Device related infection 13.98 9.96 144 478259 32041 70418000
Motor developmental delay 13.92 9.96 12 478391 222 70449819
Hyperbilirubinaemia 13.90 9.96 92 478311 22476 70427565
Alcohol interaction 13.88 9.96 7 478396 4646 70445395
Blood folate increased 13.82 9.96 17 478386 485 70449556
Amniotic fluid volume increased 13.80 9.96 10 478393 142 70449899
Wound infection pseudomonas 13.79 9.96 32 478371 1552 70448489
Foetal growth restriction 13.77 9.96 36 478367 1883 70448158
Acute myocardial infarction 13.77 9.96 380 478023 72507 70377534
Strongyloidiasis 13.76 9.96 4 478399 3719 70446322
Type 1 diabetes mellitus 13.70 9.96 13 478390 6201 70443840
Radiation inflammation 13.68 9.96 18 478385 550 70449491
Ataxia 13.63 9.96 96 478307 23121 70426920
Hypercapnia 13.56 9.96 22 478381 8307 70441734
Taste disorder 13.52 9.96 36 478367 11349 70438692
Cervical incompetence 13.50 9.96 17 478386 497 70449544
Dry skin 13.49 9.96 281 478122 55650 70394391
Renal cancer 13.48 9.96 38 478365 11758 70438283
Finger deformity 13.46 9.96 79 478324 6057 70443984
Pancreatic steatosis 13.45 9.96 25 478378 1035 70449006
Pyelonephritis acute 13.40 9.96 73 478330 5444 70444597
Epstein-Barr virus infection 13.32 9.96 45 478358 13153 70436888
Leukopenia 13.31 9.96 585 477818 105975 70344066
Clear cell renal cell carcinoma 13.30 9.96 40 478363 2270 70447771
Joint warmth 13.26 9.96 31 478372 1511 70448530
Oesophageal carcinoma 13.22 9.96 27 478376 9339 70440702
Serum ferritin increased 13.22 9.96 105 478298 8900 70441141
Gestational hypertension 13.15 9.96 34 478369 1766 70448275
Joint lock 13.14 9.96 47 478356 2920 70447121
Hepatitis fulminant 13.12 9.96 15 478388 6566 70443475
Product preparation error 13.09 9.96 7 478396 4495 70445546
Injection site urticaria 13.09 9.96 128 478275 11510 70438531
Delivery 13.08 9.96 18 478385 575 70449466
Haemoglobin decreased 13.07 9.96 1578 476825 203581 70246460
Hepatic cyst 13.06 9.96 73 478330 5498 70444543
Ankylosing spondylitis 13.05 9.96 128 478275 11518 70438523
C-reactive protein decreased 13.04 9.96 41 478362 2383 70447658
Foot operation 12.99 9.96 66 478337 4791 70445250
Intestinal stenosis 12.97 9.96 51 478352 3316 70446725
Angina unstable 12.97 9.96 59 478344 15834 70434207
Visual acuity reduced 12.95 9.96 123 478280 27807 70422234
Mood altered 12.95 9.96 62 478341 16413 70433628
Capillary fragility 12.92 9.96 11 478392 200 70449841
Bladder cancer 12.91 9.96 66 478337 17176 70432865
Mass 12.88 9.96 165 478238 15861 70434180
Antibody test positive 12.88 9.96 42 478361 2489 70447552
Anal fissure 12.88 9.96 79 478324 6154 70443887
Human anti-human antibody test 12.84 9.96 15 478388 405 70449636
Prostatic specific antigen increased 12.77 9.96 28 478375 9438 70440603
Head injury 12.77 9.96 158 478245 33983 70416058
Maternal exposure during breast feeding 12.74 9.96 39 478364 2235 70447806
Virologic failure 12.73 9.96 5 478398 3845 70446196
Eyelid ptosis 12.73 9.96 31 478372 10071 70439970
Dermatitis atopic 12.69 9.96 26 478377 8981 70441060
Breast abscess 12.68 9.96 27 478376 1235 70448806
Labelled drug-drug interaction medication error 12.63 9.96 103 478300 24024 70426017
Oxygen consumption increased 12.59 9.96 8 478395 4672 70445369
Postpartum haemorrhage 12.58 9.96 30 478373 1481 70448560
Swollen tongue 12.55 9.96 175 478228 36871 70413170
Sleep disorder due to a general medical condition 12.54 9.96 33 478370 10443 70439598
Cyst 12.46 9.96 136 478267 12583 70437458
Cellulitis 12.43 9.96 800 477603 98128 70351913
Salivary hypersecretion 12.42 9.96 45 478358 12880 70437161
Knee operation 12.41 9.96 67 478336 4980 70445061
Complications of transplanted kidney 12.41 9.96 13 478390 5921 70444120
Intracranial pressure increased 12.38 9.96 19 478384 7337 70442704
Reticulocyte count increased 12.35 9.96 27 478376 1258 70448783
Defaecation disorder 12.30 9.96 18 478385 609 70449432
Metastases to meninges 12.29 9.96 3 478400 3133 70446908
Iodine allergy 12.26 9.96 17 478386 547 70449494
Plasmacytoma 12.24 9.96 6 478397 4048 70445993
Enterocolitis 12.22 9.96 46 478357 13020 70437021
Hypoxic-ischaemic encephalopathy 12.18 9.96 19 478384 7289 70442752
Immune-mediated myositis 12.18 9.96 3 478400 3113 70446928
Depressed mood 12.15 9.96 215 478188 43605 70406436
Metastasis 12.12 9.96 14 478389 6100 70443941
Prothrombin consumption time prolonged 12.08 9.96 6 478397 40 70450001
Toothache 12.08 9.96 183 478220 18247 70431794
Chondropathy 12.08 9.96 40 478363 2390 70447651
Accessory spleen 12.06 9.96 10 478393 175 70449866
Urinary retention 12.05 9.96 266 478137 52254 70397787
Dry eye 12.03 9.96 294 478109 31988 70418053
Bone density abnormal 12.03 9.96 45 478358 2858 70447183
Weight decreased 12.02 9.96 2322 476081 308166 70141875
Ketoacidosis 12.02 9.96 19 478384 7250 70442791
Vertigo 11.99 9.96 326 478077 62317 70387724
Atrioventricular block complete 11.95 9.96 57 478346 15106 70434935
Failed induction of labour 11.90 9.96 12 478391 273 70449768
Threatened labour 11.89 9.96 17 478386 563 70449478
Chronic graft versus host disease 11.87 9.96 17 478386 6753 70443288
COVID-19 pneumonia 11.86 9.96 93 478310 21876 70428165
Colitis microscopic 11.85 9.96 27 478376 8978 70441063
Immune effector cell-associated neurotoxicity syndrome 11.85 9.96 6 478397 3972 70446069
Tooth infection 11.79 9.96 166 478237 16297 70433744
Personality disorder 11.77 9.96 12 478391 5536 70444505
Persecutory delusion 11.77 9.96 8 478395 4509 70445532
Respiratory syncytial virus infection 11.74 9.96 21 478382 7634 70442407
Heart rate irregular 11.73 9.96 273 478130 29470 70420571
Toxoplasma serology positive 11.72 9.96 6 478397 43 70449998
Purging 11.72 9.96 6 478397 43 70449998
Arthropod bite 11.69 9.96 87 478316 7228 70442813
Generalised tonic-clonic seizure 11.68 9.96 204 478199 41457 70408584
Tendon disorder 11.68 9.96 80 478323 6471 70443570
Left ventricular dysfunction 11.67 9.96 72 478331 17885 70432156
Troponin increased 11.66 9.96 65 478338 16549 70433492
Euglycaemic diabetic ketoacidosis 11.64 9.96 14 478389 5993 70444048
Respiratory tract infection viral 11.58 9.96 51 478352 3490 70446551
Anal prolapse 11.56 9.96 7 478396 72 70449969
Diverticular perforation 11.52 9.96 70 478333 5434 70444607
Diaphragmatic disorder 11.51 9.96 30 478373 1566 70448475
Device occlusion 11.48 9.96 35 478368 10560 70439481
B-cell lymphoma 11.44 9.96 77 478326 6192 70443849
Mesothelioma 11.42 9.96 13 478390 341 70449700
Anticholinergic syndrome 11.39 9.96 3 478400 2977 70447064
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.38 9.96 4 478399 3293 70446748
Device dislocation 11.36 9.96 97 478306 22410 70427631
Anaemia 11.35 9.96 2477 475926 400946 70049095
Umbilical hernia 11.34 9.96 67 478336 5149 70444892
Hyperuricaemia 11.34 9.96 37 478366 10929 70439112
Epstein-Barr virus associated lymphoproliferative disorder 11.33 9.96 4 478399 3285 70446756
Rheumatic disorder 11.33 9.96 39 478364 2377 70447664
Lymphoproliferative disorder 11.30 9.96 68 478335 5261 70444780
Hypothyroidism 11.29 9.96 229 478174 45526 70404515
Abortion induced 11.28 9.96 80 478323 6545 70443496
Muscular weakness 11.27 9.96 792 477611 137544 70312497
Coronary artery bypass 11.26 9.96 14 478389 5906 70444135
Osteoporotic fracture 11.25 9.96 53 478350 3731 70446310
Incoherent 11.24 9.96 20 478383 7286 70442755
Hepatic cancer 11.21 9.96 31 478372 9652 70440389
Hypophagia 11.19 9.96 205 478198 41365 70408676
Drug specific antibody 11.18 9.96 38 478365 2301 70447740
Inadequate analgesia 11.15 9.96 7 478396 4115 70445926
Iron deficiency 11.15 9.96 90 478313 7666 70442375
Nail injury 11.14 9.96 16 478387 532 70449509
Haemodialysis 11.10 9.96 70 478333 17296 70432745
Congenital umbilical hernia 11.08 9.96 4 478399 10 70450031
Hypoventilation 11.08 9.96 17 478386 6565 70443476
Squamous cell carcinoma of lung 11.04 9.96 37 478366 2225 70447816
Face oedema 11.02 9.96 115 478288 25524 70424517
Mitochondrial toxicity 10.99 9.96 3 478400 2907 70447134
Pyrexia 10.97 9.96 3799 474604 603153 69846888
Cytomegalovirus infection reactivation 10.95 9.96 18 478385 6763 70443278
Hepatic cytolysis 10.95 9.96 80 478323 19112 70430929
Ileus paralytic 10.95 9.96 27 478376 8734 70441307
Plasma cell myeloma recurrent 10.93 9.96 8 478395 4338 70445703
Hyperhomocysteinaemia 10.86 9.96 14 478389 419 70449622
Hydrocephalus 10.84 9.96 24 478379 8061 70441980
Stress at work 10.83 9.96 23 478380 1050 70448991
Tooth disorder 10.80 9.96 224 478179 23714 70426327
Multiple drug therapy 10.80 9.96 4 478399 3188 70446853
Hyperthermia 10.76 9.96 67 478336 16604 70433437
Complication associated with device 10.74 9.96 62 478341 15651 70434390
Kidney transplant rejection 10.73 9.96 33 478370 9928 70440113
Medical device site joint infection 10.71 9.96 11 478392 256 70449785
Myofascial pain syndrome 10.70 9.96 32 478371 1810 70448231
Upper respiratory tract infection 10.68 9.96 645 477758 78629 70371412
Hypertelorism 10.67 9.96 8 478395 120 70449921
Hepatitis E antibody positive 10.67 9.96 11 478392 257 70449784
Therapy change 10.66 9.96 18 478385 6691 70443350
Hypernatraemia 10.64 9.96 47 478356 12714 70437327
Catheter management 10.63 9.96 5 478398 3454 70446587
Haemolysis 10.63 9.96 122 478281 11429 70438612
Gastrooesophageal sphincter insufficiency 10.60 9.96 10 478393 209 70449832
Skin ulcer haemorrhage 10.60 9.96 15 478388 492 70449549
Drug tolerance 10.57 9.96 86 478317 7342 70442699
Personality change 10.57 9.96 28 478375 8842 70441199
Nervousness 10.54 9.96 147 478256 30973 70419068
Liver transplant 10.53 9.96 8 478395 4258 70445783
Vanishing twin syndrome 10.51 9.96 7 478396 86 70449955
Vacuum extractor delivery 10.51 9.96 8 478395 123 70449918
Multiple allergies 10.43 9.96 23 478380 7737 70442304
Invasive ductal breast carcinoma 10.39 9.96 71 478332 5738 70444303
Pelvic fracture 10.39 9.96 119 478284 11142 70438899
Gastroenteritis 10.38 9.96 280 478123 30933 70419108
Therapy partial responder 10.36 9.96 46 478357 12428 70437613
Corneal degeneration 10.35 9.96 8 478395 126 70449915
Skin neoplasm excision 10.34 9.96 21 478382 929 70449112
Pericardial effusion 10.34 9.96 209 478194 41567 70408474
Dermatitis allergic 10.33 9.96 162 478241 16269 70433772
Ligament rupture 10.30 9.96 43 478360 2874 70447167
Photophobia 10.29 9.96 180 478223 18470 70431571
Cleft lip and palate 10.29 9.96 9 478394 170 70449871
Injection site haemorrhage 10.28 9.96 235 478168 25292 70424749
Presyncope 10.28 9.96 184 478219 37254 70412787
Extra dose administered 10.26 9.96 21 478382 7256 70442785
Injection site extravasation 10.23 9.96 97 478306 8649 70441392
Device breakage 10.22 9.96 31 478372 9367 70440674
Catatonia 10.21 9.96 25 478378 8108 70441933
Urine ketone body present 10.21 9.96 5 478398 3374 70446667
Osteochondrosis 10.20 9.96 29 478374 1594 70448447
Chills 10.20 9.96 839 477564 143947 70306094
Catheter site erythema 10.17 9.96 11 478392 4937 70445104
Skin graft failure 10.15 9.96 10 478393 221 70449820
Cholecystitis chronic 10.14 9.96 31 478372 9345 70440696
Laryngospasm 10.11 9.96 6 478397 3637 70446404
Mean cell volume increased 10.11 9.96 69 478334 5575 70444466
Abortion incomplete 10.09 9.96 4 478399 3058 70446983
Lordosis 10.04 9.96 12 478391 332 70449709
Epistaxis 10.00 9.96 578 477825 102049 70347992
Swollen joint count 9.99 9.96 21 478382 952 70449089
Complication of pregnancy 9.98 9.96 12 478391 334 70449707
Post-traumatic stress disorder 9.97 9.96 9 478394 4398 70445643

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Small for dates baby 17.38 16.49 150 2722 2659 84261

Pharmacologic Action:

SourceCodeDescription
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE02 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03BB01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Folic acid and derivatives
ATC B03BB51 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Folic acid and derivatives
ATC V04CX02 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Other diagnostic agents
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Vitamin deficiency indication 85670002
Iron deficiency anemia indication 87522002
Mineral deficiency indication 111379007
Folic acid deficiency indication 190633005
Pregnancy, function indication 289908002
Breastfeeding (mother) indication 413712001
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Prevention of Vitamin B12 Deficiency indication
Homocystinuria off-label use 11282001 DOID:9263
Homocystinemia off-label use 52311001
Prevention of Fetal Neural Tube Defects during Pregnancy off-label use
Peptic ulcer contraindication 13200003 DOID:750
Bipolar disorder contraindication 13746004 DOID:3312
Constipation contraindication 14760008 DOID:2089
Operation on stomach contraindication 16453004
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hemosiderosis contraindication 39011001 DOID:12119
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Diabetes mellitus contraindication 73211009 DOID:9351
Phototoxicity contraindication 84326006
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Osteolysis contraindication 203522001
Hypomania contraindication 231496004
Esophageal dysmotility contraindication 266434009 DOID:9192
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.46 acidic
pKa2 5.15 acidic
pKa3 12.96 acidic
pKa4 4.55 Basic
pKa5 4.15 Basic
pKa6 2.28 Basic
pKa7 1.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thymidylate synthase Enzyme Ki 4.40 CHEMBL
Aldose reductase Enzyme IC50 4.28 CHEMBL
Dihydrofolate reductase Enzyme Kd 6.09 CHEMBL
Dihydrofolate reductase Enzyme Kd 6.09 CHEMBL

External reference:

IDSource
4017507 VUID
N0000145892 NUI
D00070 KEGG_DRUG
6484-89-5 SECONDARY_CAS_RN
4017507 VANDF
C0016410 UMLSCUI
CHEBI:27470 CHEBI
FA PDB_CHEM_ID
CHEMBL1622 ChEMBL_ID
CHEMBL2107429 ChEMBL_ID
D005492 MESH_DESCRIPTOR_UI
DB00158 DRUGBANK_ID
4563 IUPHAR_LIGAND_ID
68 INN_ID
935E97BOY8 UNII
135398658 PUBCHEM_CID
1300473 RXNORM
264 MMSL
4759 MMSL
d00241 MMSL
001049 NDDF
126224002 SNOMEDCT_US
6247001 SNOMEDCT_US
63718003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 1 mg ORAL unapproved drug other 17 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 1 mg ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 1 mg ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 1 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 1.40 mg ORAL unapproved drug other 15 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 1.40 mg ORAL unapproved drug other 15 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 1 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 1 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 1 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 1 mg ORAL Unapproved drug other 9 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 1 mg ORAL Unapproved drug other 11 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-7814 TABLET 1 mg ORAL ANDA 12 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-7814 TABLET 1 mg ORAL ANDA 12 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-8427 TABLET 1 mg ORAL ANDA 11 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1700 ug ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 0.40 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 680 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 680 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 0.40 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 1 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 1700 ug ORAL UNAPPROVED DRUG OTHER 14 sections