folic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1231 59-30-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • folic acid
  • acifolic
  • aspol
  • cytofol
  • folacid
  • pteroylglutamic acid
  • folate sodium
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
  • Molecular weight: 441.40
  • Formula: C19H19N7O6
  • CLOGP: -1.43
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 207.93
  • ALOGS: -3.74
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 mg O
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.43 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 75 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 9.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 52 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1946 FDA LEDERLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1497.13 10.12 3092 399880 117074 50085078
Systemic lupus erythematosus 1393.39 10.12 3301 399671 137321 50064831
Glossodynia 1188.11 10.12 2753 400219 112816 50089336
Maternal exposure during pregnancy 1000.67 10.12 3170 399802 156608 50045544
Rheumatoid arthritis 993.76 10.12 3704 399268 198846 50003306
Hand deformity 943.14 10.12 2307 400665 97892 50104260
Arthropathy 834.32 10.12 2959 400013 154947 50047205
Alopecia 814.02 10.12 3981 398991 241066 49961086
Completed suicide 794.57 10.12 69 402903 131820 50070332
Abdominal discomfort 780.59 10.12 3779 399193 227862 49974290
Wound 771.03 10.12 2215 400757 103579 50098573
Infusion related reaction 599.46 10.12 2806 400166 166751 50035401
Synovitis 598.01 10.12 2255 400717 121610 50080542
Pericarditis 592.05 10.12 1667 401305 77022 50125130
Anti-cyclic citrullinated peptide antibody positive 571.37 10.12 1536 401436 69051 50133101
Discomfort 547.22 10.12 2002 400970 106378 50095774
Contraindicated product administered 539.56 10.12 2483 400489 146475 50055677
Toxicity to various agents 526.79 10.12 549 402423 211950 49990202
Swelling 512.93 10.12 3038 399934 197834 50004318
Death 490.94 10.12 1173 401799 324206 49877946
Joint swelling 486.59 10.12 3481 399491 241805 49960347
Pain 463.97 10.12 6812 396160 572091 49630061
Exposure during pregnancy 397.86 10.12 1962 401010 119053 50083099
Product use issue 367.34 10.12 2239 400733 147236 50054916
Rheumatoid factor positive 346.57 10.12 1027 401945 48832 50153320
Duodenal ulcer perforation 330.92 10.12 954 402018 44657 50157495
Helicobacter infection 316.66 10.12 993 401979 48709 50153443
Arthralgia 304.45 10.12 5042 397930 433660 49768492
Drug abuse 303.02 10.12 55 402917 59791 50142361
Intentional overdose 286.75 10.12 72 402900 62432 50139720
Hepatic enzyme increased 284.90 10.12 1972 401000 135408 50066744
Hip arthroplasty 223.14 10.12 639 402333 29790 50172362
Musculoskeletal stiffness 222.91 10.12 1768 401204 126713 50075439
Foetal exposure during pregnancy 218.83 10.12 593 402379 26766 50175386
Gestational diabetes 213.44 10.12 280 402692 7185 50194967
Drug interaction 211.33 10.12 845 402127 198776 50003376
Knee arthroplasty 208.22 10.12 694 402278 35152 50167000
Drug intolerance 199.16 10.12 2640 400332 216464 49985688
Febrile neutropenia 198.02 10.12 294 402678 97373 50104779
Therapeutic product effect decreased 196.36 10.12 1797 401175 134253 50067899
Overdose 191.87 10.12 311 402661 99416 50102736
Drug hypersensitivity 185.29 10.12 1204 401768 249806 49952346
Treatment failure 183.69 10.12 1788 401184 135849 50066303
Suicide attempt 182.16 10.12 92 402880 51640 50150512
Cardiac arrest 180.33 10.12 241 402731 83410 50118742
Psoriatic arthropathy 170.66 10.12 785 402187 46247 50155905
Malignant neoplasm progression 169.66 10.12 175 402797 67949 50134203
Disease progression 168.92 10.12 316 402656 95550 50106602
Depressed level of consciousness 167.61 10.12 103 402869 51850 50150302
Nasopharyngitis 157.93 10.12 2282 400690 190645 50011507
Nausea 155.03 10.12 4358 398614 701040 49501112
Diarrhoea 154.30 10.12 3542 399430 584934 49617218
Device expulsion 153.65 10.12 23 402949 28799 50173353
Red blood cell sedimentation rate abnormal 153.14 10.12 376 402596 15967 50186185
Constipation 139.88 10.12 885 402087 184823 50017329
Small for dates baby 138.67 10.12 155 402817 3350 50198802
C-reactive protein abnormal 134.51 10.12 507 402465 27302 50174850
Sickle cell anaemia with crisis 130.81 10.12 171 402801 4372 50197780
Impaired healing 129.63 10.12 976 401996 68810 50133342
Sedation 127.94 10.12 42 402930 30568 50171584
Acute kidney injury 126.07 10.12 1184 401788 226874 49975278
Hypersensitivity 125.85 10.12 2409 400563 212752 49989400
Rheumatic fever 125.39 10.12 356 402616 16511 50185641
Anxiety 125.37 10.12 863 402109 176743 50025409
Abortion spontaneous 124.31 10.12 659 402313 41113 50161039
Swollen joint count increased 121.56 10.12 325 402647 14548 50187604
Pregnancy 119.64 10.12 510 402462 29067 50173085
Dizziness 117.99 10.12 1994 400978 344375 49857777
Bradycardia 114.67 10.12 211 402761 64215 50137937
Respiratory arrest 113.96 10.12 48 402924 29961 50172191
Dyspnoea 113.23 10.12 3410 399562 544198 49657954
Tremor 113.05 10.12 500 402472 114403 50087749
Agitation 110.81 10.12 158 402814 53226 50148926
Live birth 108.32 10.12 332 402640 16076 50186076
Electrocardiogram QT prolonged 108.26 10.12 153 402819 51733 50150419
Lactic acidosis 103.65 10.12 69 402903 33286 50168866
Somnolence 102.60 10.12 767 402205 154218 50047934
Asthenia 102.12 10.12 1857 401115 317185 49884967
Multiple sclerosis relapse 98.58 10.12 118 402854 42846 50159306
Neutropenia 96.64 10.12 735 402237 147230 50054922
Hypotension 96.39 10.12 1308 401664 234161 49967991
Neuropathy peripheral 93.98 10.12 423 402549 96334 50105818
Cardiac failure 93.54 10.12 302 402670 75738 50126414
Vomiting 93.44 10.12 2876 400096 457882 49744270
Psoriasis 92.75 10.12 898 402074 68102 50134050
Insomnia 92.69 10.12 917 402055 173948 50028204
Renal failure 89.33 10.12 491 402481 106142 50096010
Hyperhidrosis 89.24 10.12 387 402585 89039 50113113
Arthritis 87.55 10.12 1066 401906 85655 50116497
Sleep disorder due to general medical condition, insomnia type 86.08 10.12 485 402487 30962 50171190
Folliculitis 85.29 10.12 570 402402 38655 50163497
Myalgia 83.81 10.12 612 402360 123707 50078445
Cardio-respiratory arrest 83.60 10.12 191 402781 53701 50148451
Muscle injury 82.95 10.12 543 402429 36568 50165584
Rhabdomyolysis 82.50 10.12 114 402858 38913 50163239
Intentional self-injury 81.50 10.12 41 402931 23071 50179081
Drug ineffective 81.32 10.12 7572 395400 811761 49390391
Neoplasm progression 80.71 10.12 68 402904 29089 50173063
Drug withdrawal syndrome 80.50 10.12 50 402922 25031 50177121
Osteoarthritis 78.94 10.12 865 402107 67741 50134411
Rash 78.86 10.12 4247 398725 433224 49768928
Caesarean section 78.02 10.12 288 402684 15351 50186801
Drug dependence 77.65 10.12 30 402942 19729 50182423
Product quality issue 75.98 10.12 80 402892 30778 50171374
Condition aggravated 75.09 10.12 2984 399988 294074 49908078
Tachycardia 73.72 10.12 478 402494 99285 50102867
Lower respiratory tract infection 73.04 10.12 1114 401858 94087 50108065
Basal cell carcinoma 71.91 10.12 372 402600 22984 50179168
Blister 71.61 10.12 1015 401957 84403 50117749
Palmar-plantar erythrodysaesthesia syndrome 70.35 10.12 36 402936 20062 50182090
Hypoxia 69.36 10.12 194 402778 50929 50151223
Hyponatraemia 69.34 10.12 464 402508 95675 50106477
Cardiac failure congestive 68.79 10.12 392 402580 83990 50118162
Hepatic failure 68.54 10.12 94 402878 32189 50169963
Feeling abnormal 68.19 10.12 654 402318 124838 50077314
Congenital umbilical hernia 68.02 10.12 38 402934 275 50201877
Syncope 67.06 10.12 512 402460 102490 50099662
Drug resistance 66.49 10.12 34 402938 18955 50183197
Fatigue 66.27 10.12 6514 396458 701087 49501065
Injection site erythema 65.87 10.12 898 402074 74038 50128114
Blood pressure fluctuation 65.36 10.12 499 402473 35324 50166828
Joint effusion 65.13 10.12 240 402732 12781 50189371
Urticaria 65.09 10.12 688 402284 128873 50073279
Asthma 65.01 10.12 430 402542 88907 50113245
Balance disorder 64.76 10.12 315 402657 70275 50131877
Serotonin syndrome 64.37 10.12 61 402911 24652 50177500
Drug reaction with eosinophilia and systemic symptoms 64.21 10.12 79 402893 28345 50173807
Muscle spasms 63.36 10.12 666 402306 124887 50077265
No adverse event 63.34 10.12 106 402866 33472 50168680
Atrial septal defect 62.74 10.12 149 402823 6192 50195960
Hypoglycaemia 62.33 10.12 218 402754 53363 50148789
Intentional product misuse 62.18 10.12 179 402793 46555 50155597
Sopor 61.93 10.12 41 402931 19838 50182314
Injection site pruritus 61.91 10.12 541 402431 39870 50162282
Fluid retention 61.70 10.12 202 402770 50447 50151705
Juvenile idiopathic arthritis 61.57 10.12 94 402878 2785 50199367
Ventricular septal defect 61.12 10.12 113 402859 3928 50198224
Premature delivery 60.88 10.12 359 402613 23304 50178848
Disability assessment scale score increased 60.63 10.12 84 402888 2274 50199878
Blood glucose increased 59.40 10.12 329 402643 70995 50131157
Depression 57.92 10.12 947 402025 164476 50037676
Renal impairment 57.69 10.12 359 402613 75302 50126850
Sedation complication 57.37 10.12 3 402969 8763 50193389
Respiratory failure 57.13 10.12 458 402514 90723 50111429
Premature labour 56.96 10.12 211 402761 11265 50190887
Dysmorphism 56.93 10.12 78 402894 2089 50200063
Muscle spasticity 56.92 10.12 33 402939 17151 50185001
Diabetic ketoacidosis 56.85 10.12 36 402936 17836 50184316
Red blood cell sedimentation rate increased 56.63 10.12 415 402557 29001 50173151
Irritable bowel syndrome 56.62 10.12 643 402329 50798 50151354
Pre-eclampsia 56.14 10.12 166 402806 7878 50194274
Coma 55.61 10.12 248 402724 56631 50145521
Joint laxity 55.15 10.12 81 402891 2317 50199835
Foot deformity 55.06 10.12 300 402672 18910 50183242
Pancytopenia 55.03 10.12 958 402014 83072 50119080
Hyperglycaemia 54.87 10.12 131 402841 36274 50165878
Mental status changes 54.29 10.12 131 402841 36141 50166011
Vision blurred 52.58 10.12 388 402584 78259 50123893
Metastases to bone 51.00 10.12 41 402931 17954 50184198
Emotional distress 50.88 10.12 94 402878 28569 50173583
Hallucination 50.23 10.12 196 402776 46461 50155691
Hospitalisation 49.42 10.12 327 402645 67610 50134542
Metabolic acidosis 49.28 10.12 152 402820 38673 50163479
Chest discomfort 49.18 10.12 486 402486 92236 50109916
Neutrophil count decreased 49.13 10.12 194 402778 45832 50156320
Cognitive disorder 49.02 10.12 183 402789 43940 50158212
White blood cell count decreased 48.54 10.12 646 402326 116076 50086076
Blood pressure diastolic abnormal 48.05 10.12 174 402798 9187 50192965
Multiple organ dysfunction syndrome 47.70 10.12 222 402750 50115 50152037
Decreased appetite 47.48 10.12 1227 401745 199696 50002456
Mydriasis 47.28 10.12 13 402959 10614 50191538
Tuberculosis 47.24 10.12 182 402790 9901 50192251
Memory impairment 46.82 10.12 405 402567 78955 50123197
Osteoporosis 46.73 10.12 555 402417 44324 50157828
Myocardial infarction 46.23 10.12 469 402503 88558 50113594
Orthostatic hypotension 46.11 10.12 104 402868 29377 50172775
Injection site swelling 45.90 10.12 522 402450 41251 50160901
Neck deformity 45.76 10.12 67 402905 1911 50200241
Cytomegalovirus infection 44.86 10.12 46 402926 17916 50184236
Respiratory disorder 44.83 10.12 115 402857 31072 50171080
Maternal exposure before pregnancy 44.43 10.12 121 402851 5476 50196676
Respiratory depression 44.35 10.12 20 402952 11990 50190162
Contusion 44.11 10.12 1188 401784 110995 50091157
Anaphylactic reaction 44.10 10.12 251 402721 53804 50148348
Ill-defined disorder 43.63 10.12 644 402328 54010 50148142
Maternal drugs affecting foetus 43.58 10.12 113 402859 4964 50197188
Premature rupture of membranes 43.57 10.12 106 402866 4474 50197678
Creatinine renal clearance decreased 43.54 10.12 20 402952 11861 50190291
Seizure 43.52 10.12 668 402304 117206 50084946
Bone erosion 43.06 10.12 196 402776 11491 50190661
Pain in jaw 42.94 10.12 159 402813 38269 50163883
Acute hepatic failure 42.85 10.12 37 402935 15640 50186512
Poisoning 42.42 10.12 23 402949 12406 50189746
Grip strength decreased 42.25 10.12 200 402772 11921 50190231
Suicidal ideation 42.11 10.12 263 402709 55122 50147030
Polyarthritis 42.10 10.12 149 402823 7778 50194374
Injection site reaction 42.10 10.12 595 402377 49437 50152715
Sinusitis 41.77 10.12 1708 401264 168850 50033302
Dyspnoea exertional 41.74 10.12 238 402734 50995 50151157
Respiratory disorder neonatal 41.38 10.12 44 402928 897 50201255
Abnormal behaviour 40.96 10.12 58 402914 19600 50182552
Unresponsive to stimuli 40.89 10.12 117 402855 30492 50171660
C-reactive protein increased 40.73 10.12 750 402222 65724 50136428
Fibromyalgia 40.33 10.12 541 402431 44437 50157715
Ejection fraction decreased 40.25 10.12 53 402919 18467 50183685
Multiple fractures 40.17 10.12 130 402842 6481 50195671
Loss of personal independence in daily activities 40.06 10.12 782 402190 69268 50132884
Hepatic function abnormal 40.03 10.12 130 402842 32551 50169601
Blood cholesterol increased 40.00 10.12 640 402332 54575 50147577
Encephalopathy 39.99 10.12 136 402836 33575 50168577
Speech disorder 39.77 10.12 147 402825 35401 50166751
Flushing 39.53 10.12 342 402630 66673 50135479
Blood pressure systolic abnormal 39.35 10.12 143 402829 7563 50194589
Type 2 diabetes mellitus 38.88 10.12 432 402540 33943 50168209
Blood pressure decreased 38.73 10.12 273 402699 55636 50146516
Pulmonary embolism 38.35 10.12 574 402398 101130 50101022
Loss of consciousness 38.30 10.12 592 402380 103761 50098391
Angioedema 38.21 10.12 162 402810 37514 50164638
Peripheral swelling 38.09 10.12 2005 400967 203931 49998221
Drug level increased 38.06 10.12 59 402913 19209 50182943
Palpitations 37.86 10.12 527 402445 93979 50108173
Developmental hip dysplasia 37.80 10.12 49 402923 1242 50200910
Blood pressure systolic increased 37.61 10.12 440 402532 35009 50167143
Drug ineffective for unapproved indication 37.59 10.12 70 402902 21211 50180941
Pulmonary arterial hypertension 37.53 10.12 65 402907 20254 50181898
Injection site pain 37.37 10.12 1153 401819 109871 50092281
Dehydration 37.33 10.12 926 402046 151523 50050629
Dysgeusia 37.25 10.12 171 402801 38745 50163407
Chest pain 37.19 10.12 1098 401874 175784 50026368
Device dislocation 37.06 10.12 72 402900 21474 50180678
Blood creatine phosphokinase increased 36.55 10.12 99 402873 26268 50175884
Disturbance in attention 36.19 10.12 127 402845 31059 50171093
Foetal death 36.18 10.12 145 402827 8035 50194117
Platelet count decreased 35.76 10.12 575 402397 100151 50102001
Product dose omission issue 35.52 10.12 1154 401818 182684 50019468
Anaemia 34.98 10.12 1648 401324 250808 49951344
Akathisia 34.90 10.12 11 402961 8218 50193934
Torsade de pointes 34.77 10.12 26 402946 11809 50190343
Metastases to liver 34.74 10.12 67 402905 20037 50182115
Infective pulmonary exacerbation of cystic fibrosis 34.58 10.12 10 402962 7899 50194253
Rheumatoid nodule 34.57 10.12 196 402776 12539 50189613
Extrapyramidal disorder 34.39 10.12 26 402946 11744 50190408
Product use in unapproved indication 34.21 10.12 683 402289 115136 50087016
Ascites 34.07 10.12 158 402814 35703 50166449
Brain oedema 34.05 10.12 29 402943 12341 50189811
Large for dates baby 33.85 10.12 29 402943 446 50201706
Shock 33.82 10.12 71 402901 20579 50181573
Pulmonary tuberculosis 33.54 10.12 92 402880 4181 50197971
Joint destruction 33.45 10.12 87 402885 3829 50198323
Hypothermia 33.28 10.12 28 402944 11988 50190164
Neuroleptic malignant syndrome 33.28 10.12 24 402948 11106 50191046
Haemorrhage 33.20 10.12 269 402703 53172 50148980
Inflammation 33.10 10.12 637 402335 56275 50145877
Latent tuberculosis 33.02 10.12 62 402910 2181 50199971
Bone pain 33.01 10.12 230 402742 46999 50155153
Back pain 32.98 10.12 1424 401548 218606 49983546
Product administration error 32.88 10.12 67 402905 19632 50182520
Talipes 32.86 10.12 48 402924 1366 50200786
Thrombocytopenia 32.76 10.12 770 402202 126903 50075249
Dysarthria 32.53 10.12 170 402802 37233 50164919
Malignant melanoma 32.51 10.12 163 402809 9945 50192207
Cerebrovascular accident 32.45 10.12 544 402428 94136 50108016
Restlessness 32.34 10.12 98 402874 25075 50177077
Neurotoxicity 32.22 10.12 42 402930 14698 50187454
Altered state of consciousness 32.10 10.12 80 402892 21830 50180322
Limb deformity 31.94 10.12 83 402889 3651 50198501
Wrong technique in product usage process 31.54 10.12 286 402686 55224 50146928
Localised infection 31.48 10.12 326 402646 25159 50176993
Enthesopathy 31.41 10.12 127 402845 7066 50195086
Device difficult to use 31.32 10.12 20 402952 9866 50192286
Joint stiffness 31.19 10.12 374 402598 29934 50172218
Posterior reversible encephalopathy syndrome 31.15 10.12 44 402928 14884 50187268
Blood bilirubin increased 31.12 10.12 140 402832 31898 50170254
Aspartate aminotransferase increased 30.87 10.12 436 402536 77562 50124590
Dysphagia 30.79 10.12 433 402539 77085 50125067
Blood alkaline phosphatase increased 30.74 10.12 174 402798 37352 50164800
Nodule 30.54 10.12 236 402736 16767 50185385
Blood pressure diastolic decreased 30.18 10.12 233 402739 16548 50185604
Headache 30.13 10.12 3553 399419 502982 49699170
Skin ulcer 30.11 10.12 421 402551 34897 50167255
Withdrawal syndrome 30.07 10.12 59 402913 17531 50184621
Infection 30.00 10.12 1674 401298 171280 50030872
Ventricular fibrillation 30.00 10.12 24 402948 10535 50191617
Weight increased 29.75 10.12 1926 401046 199965 50002187
Femur fracture 29.72 10.12 441 402531 37023 50165129
Arrhythmia 29.72 10.12 149 402823 32983 50169169
Chronic kidney disease 29.64 10.12 190 402782 39581 50162571
Mania 29.55 10.12 26 402946 10890 50191262
Synovial cyst 29.38 10.12 136 402836 8030 50194122
Foetal anticonvulsant syndrome 29.24 10.12 29 402943 543 50201609
Alanine aminotransferase increased 29.21 10.12 511 402461 87848 50114304
Pulmonary oedema 29.19 10.12 249 402723 48689 50153463
Pulmonary fibrosis 28.97 10.12 310 402662 24127 50178025
Irritability 28.96 10.12 122 402850 28304 50173848
Intentional product use issue 28.93 10.12 810 402162 76108 50126044
Ventricular tachycardia 28.87 10.12 51 402921 15770 50186382
Psychotic disorder 28.68 10.12 84 402888 21728 50180424
Macular degeneration 28.47 10.12 44 402928 14344 50187808
Disorientation 28.28 10.12 166 402806 35318 50166834
Injection site rash 28.21 10.12 223 402749 15954 50186198
Schizophrenia 27.81 10.12 12 402960 7385 50194767
Anaphylactic shock 27.69 10.12 76 402896 20079 50182073
Musculoskeletal pain 27.69 10.12 762 402210 71415 50130737
Osteonecrosis of jaw 27.64 10.12 149 402823 32377 50169775
Tenderness 27.63 10.12 247 402725 18318 50183834
Nightmare 27.46 10.12 54 402918 16032 50186120
Polyhydramnios 27.39 10.12 54 402918 1971 50200181
Tenosynovitis stenosans 27.34 10.12 57 402915 2167 50199985
Obstructive airways disorder 27.19 10.12 52 402920 15600 50186552
Hypokalaemia 27.16 10.12 515 402457 87477 50114675
Blood calcium decreased 27.04 10.12 80 402892 20626 50181526
Joint range of motion decreased 26.89 10.12 245 402727 18267 50183885
Haematotoxicity 26.38 10.12 15 402957 7880 50194272
Device use error 26.30 10.12 5 402967 5261 50196891
Pulmonary hypertension 26.28 10.12 157 402815 33260 50168892
Disability 26.19 10.12 183 402789 12592 50189560
Unevaluable event 25.88 10.12 238 402734 45828 50156324
Patent ductus arteriosus 25.87 10.12 78 402894 3742 50198410
Metastases to central nervous system 25.86 10.12 31 402941 11251 50190901
Dyskinesia 25.73 10.12 124 402848 27737 50174415
Arthritis infective 25.66 10.12 100 402872 5469 50196683
Smear cervix abnormal 25.61 10.12 63 402909 2678 50199474
Placental disorder 25.52 10.12 43 402929 1387 50200765
Birth mark 25.31 10.12 15 402957 123 50202029
Muscular weakness 25.22 10.12 570 402402 94443 50107709
Respiratory distress 25.18 10.12 141 402831 30348 50171804
Injection site bruising 25.07 10.12 422 402550 36346 50165806
Pleural effusion 25.06 10.12 477 402495 80977 50121175
Lethargy 25 10.12 262 402710 49170 50152982
Graft versus host disease 24.83 10.12 9 402963 6157 50195995
Bradyphrenia 24.74 10.12 9 402963 6143 50196009
Transplant rejection 24.69 10.12 24 402948 9585 50192567
Depressed mood 24.62 10.12 164 402808 33859 50168293
Product adhesion issue 24.61 10.12 3 402969 4389 50197763
Coagulopathy 24.40 10.12 68 402904 17876 50184276
Bronchospasm 24.39 10.12 51 402921 14803 50187349
Speech disorder developmental 24.35 10.12 27 402945 578 50201574
Dystonia 24.05 10.12 36 402936 11890 50190262
Complication of device insertion 24.02 10.12 9 402963 6032 50196120
Disseminated intravascular coagulation 24.00 10.12 64 402908 17071 50185081
Atrioventricular block complete 23.93 10.12 14 402958 7241 50194911
Tenosynovitis 23.85 10.12 155 402817 10410 50191742
Fear 23.84 10.12 50 402922 14499 50187653
Heart rate decreased 23.84 10.12 416 402556 36081 50166071
Hypervolaemia 23.84 10.12 113 402859 25386 50176766
Crying 23.78 10.12 83 402889 20333 50181819
Herpes zoster 23.78 10.12 735 402237 70051 50132101
Skin papilloma 23.77 10.12 81 402891 4148 50198004
COVID-19 23.73 10.12 247 402725 46415 50155737
Panic attack 23.65 10.12 77 402895 19265 50182887
Complication associated with device 23.49 10.12 51 402921 14604 50187548
Accidental exposure to product 23.47 10.12 99 402873 22958 50179194
Delirium 23.37 10.12 193 402779 37999 50164153
International normalised ratio increased 23.37 10.12 225 402747 42927 50159225
Premature baby 23.33 10.12 236 402736 18101 50184051
Acute respiratory failure 23.28 10.12 134 402838 28648 50173504
Post transplant lymphoproliferative disorder 23.24 10.12 3 402969 4201 50197951
Blood pressure diastolic increased 23.22 10.12 119 402853 7324 50194828
Cardiac failure acute 23.13 10.12 19 402953 8231 50193921
Neck mass 23.11 10.12 69 402903 3292 50198860
Hypomania 23.10 10.12 4 402968 4501 50197651
Wheezing 23.10 10.12 351 402621 61696 50140456
Laryngitis 23.09 10.12 158 402814 10798 50191354
Agitation neonatal 22.98 10.12 24 402948 479 50201673
Deep vein thrombosis 22.94 10.12 428 402544 72876 50129276
Cytokine release syndrome 22.85 10.12 21 402951 8613 50193539
Blood creatinine increased 22.82 10.12 448 402524 75712 50126440
Exomphalos 22.82 10.12 25 402947 528 50201624
Wheelchair user 22.69 10.12 89 402883 4883 50197269
Substance abuse 22.66 10.12 3 402969 4121 50198031
Abortion late 22.62 10.12 13 402959 100 50202052
Hypomagnesaemia 22.61 10.12 101 402871 23055 50179097
Fracture 22.56 10.12 219 402753 16614 50185538
Hyperlipidaemia 22.53 10.12 68 402904 17422 50184730
Gastrointestinal haemorrhage 22.36 10.12 430 402542 72891 50129261
Pancreatitis 22.32 10.12 224 402748 42390 50159762
Nervousness 22.23 10.12 129 402843 27522 50174630
Cardiogenic shock 22.05 10.12 58 402914 15541 50186611
Second primary malignancy 21.89 10.12 14 402958 6900 50195252
Gamma-glutamyltransferase increased 21.83 10.12 142 402830 29481 50172671
Infantile vomiting 21.79 10.12 13 402959 108 50202044
Asphyxia 21.72 10.12 8 402964 5419 50196733
Parkinsonism 21.71 10.12 23 402949 8824 50193328
Uterine perforation 21.70 10.12 12 402960 6403 50195749
Neonatal respiratory distress syndrome 21.69 10.12 58 402914 2596 50199556
Inappropriate antidiuretic hormone secretion 21.68 10.12 45 402927 13098 50189054
Haemorrhage intracranial 21.59 10.12 41 402931 12333 50189819
Atrial fibrillation 21.51 10.12 631 402341 101114 50101038
Vertigo 21.48 10.12 287 402685 51545 50150607
Acute graft versus host disease 21.46 10.12 3 402969 3955 50198197
Infusion site pain 21.46 10.12 41 402931 12305 50189847
Glycosylated haemoglobin increased 21.40 10.12 32 402940 10574 50191578
Venoocclusive liver disease 21.38 10.12 4 402968 4257 50197895
Synovial fluid analysis 21.34 10.12 43 402929 1595 50200557
Polyneuropathy 21.34 10.12 40 402932 12091 50190061
Stillbirth 21.32 10.12 99 402873 5853 50196299
Aggression 21.28 10.12 91 402881 21025 50181127
Stomatitis 21.26 10.12 999 401973 100345 50101807
Haemorrhage in pregnancy 21.24 10.12 44 402928 1665 50200487
Genital haemorrhage 21.24 10.12 13 402959 6561 50195591
Blood potassium decreased 21.14 10.12 190 402782 36755 50165397
Drug tolerance decreased 21.05 10.12 135 402837 9025 50193127
Anhedonia 20.96 10.12 27 402945 9497 50192655
Abdominal distension 20.90 10.12 432 402540 72471 50129681
Malaise 20.73 10.12 2347 400625 333185 49868967
Sepsis 20.58 10.12 857 402115 132068 50070084
Disease recurrence 20.57 10.12 86 402886 19995 50182157
Spinal stenosis 20.54 10.12 181 402791 13369 50188783
Tardive dyskinesia 20.11 10.12 17 402955 7262 50194890
Breast feeding 20.02 10.12 29 402943 819 50201333
Infusion site erythema 19.98 10.12 24 402948 8703 50193449
Rotator cuff repair 19.96 10.12 43 402929 1673 50200479
Loose body in joint 19.93 10.12 35 402937 1168 50200984
Oedema peripheral 19.93 10.12 1041 401931 156920 50045232
Accidental overdose 19.80 10.12 84 402888 19449 50182703
Abortion threatened 19.77 10.12 23 402949 520 50201632
Serum ferritin increased 19.73 10.12 88 402884 5114 50197038
Tumour lysis syndrome 19.70 10.12 18 402954 7403 50194749
Cholecystitis chronic 19.68 10.12 29 402943 9640 50192512
Multiple allergies 19.67 10.12 23 402949 8440 50193712
Normal newborn 19.51 10.12 105 402867 6586 50195566
Therapeutic response decreased 19.36 10.12 503 402469 46728 50155424
Acute chest syndrome 19.34 10.12 25 402947 632 50201520
Exposure to toxic agent 19.31 10.12 3 402969 3655 50198497
Thrombotic microangiopathy 19.26 10.12 25 402947 8766 50193386
Mood altered 19.22 10.12 46 402926 12727 50189425
Hyperkalaemia 18.95 10.12 269 402703 47820 50154332
Learning disorder 18.95 10.12 24 402948 594 50201558
Stress cardiomyopathy 18.80 10.12 21 402951 7866 50194286
Bradycardia neonatal 18.63 10.12 28 402944 818 50201334
Paralysis 18.62 10.12 25 402947 8639 50193513
Sinus tachycardia 18.60 10.12 97 402875 21257 50180895
Cholestasis 18.60 10.12 122 402850 25279 50176873
Leukopenia 18.52 10.12 403 402569 67125 50135027
Muscle twitching 18.47 10.12 62 402910 15369 50186783
Plasma cell myeloma 18.40 10.12 160 402812 31162 50170990
Dry skin 18.32 10.12 238 402734 42953 50159199
Oropharyngeal pain 18.08 10.12 775 402197 77026 50125126
Immunosuppression 18.04 10.12 111 402861 7315 50194837
Face oedema 17.90 10.12 77 402895 17762 50184390
Cerebral haemorrhage 17.81 10.12 134 402838 26918 50175234
Mouth ulceration 17.80 10.12 318 402654 27706 50174446
Postoperative wound infection 17.73 10.12 122 402850 8353 50193799
Erythema multiforme 17.60 10.12 28 402944 9022 50193130
Cholestasis of pregnancy 17.58 10.12 32 402940 1099 50201053
Congenital hydronephrosis 17.58 10.12 19 402953 395 50201757
Abortion missed 17.57 10.12 39 402933 1549 50200603
Aspergillus infection 17.57 10.12 17 402955 6804 50195348
B-cell lymphoma 17.51 10.12 58 402914 2927 50199225
Hemiparesis 17.50 10.12 91 402881 19957 50182195
Bronchioloalveolar carcinoma 17.50 10.12 10 402962 76 50202076
Skin exfoliation 17.47 10.12 177 402795 33435 50168717
Blood glucose decreased 17.44 10.12 80 402892 18131 50184021
Scleritis 17.43 10.12 61 402911 3166 50198986
Clear cell renal cell carcinoma 17.40 10.12 33 402939 1170 50200982
Body height below normal 17.37 10.12 44 402928 1905 50200247
Pathogen resistance 17.36 10.12 12 402960 5677 50196475
Hypophosphataemia 17.36 10.12 25 402947 8389 50193763
Status epilepticus 17.35 10.12 52 402920 13354 50188798
Catheter site erythema 17.34 10.12 5 402967 3957 50198195
Joint dislocation 17.30 10.12 162 402810 12171 50189981
Cushingoid 17.21 10.12 101 402871 6544 50195608
Cytopenia 17.20 10.12 27 402945 8748 50193404
Lupus-like syndrome 17.19 10.12 132 402840 9359 50192793
Body temperature decreased 17.17 10.12 203 402769 16192 50185960
Tachypnoea 17.16 10.12 59 402913 14518 50187634
Metastases to lung 17.13 10.12 39 402933 10981 50191171
Febrile bone marrow aplasia 17.12 10.12 15 402957 6296 50195856
Myopathy 17.10 10.12 29 402943 9110 50193042
Congenital arterial malformation 17.07 10.12 17 402955 320 50201832
Device related infection 17.06 10.12 96 402876 20639 50181513
Proteinuria 17.05 10.12 71 402901 16526 50185626
Induced labour 17.00 10.12 28 402944 886 50201266
Complication of device removal 16.90 10.12 6 402966 4158 50197994
Ketoacidosis 16.89 10.12 5 402967 3890 50198262
Fracture delayed union 16.88 10.12 48 402924 2228 50199924
Arthritis bacterial 16.87 10.12 89 402883 5540 50196612
Atrioventricular block 16.86 10.12 16 402956 6462 50195690
Oral herpes 16.84 10.12 245 402727 20480 50181672
Sleep apnoea syndrome 16.79 10.12 116 402856 23752 50178400
Muscle rigidity 16.77 10.12 33 402939 9796 50192356
Blood iron increased 16.75 10.12 35 402937 1333 50200819
Incorrect route of product administration 16.71 10.12 84 402888 18582 50183570
Oedema 16.70 10.12 428 402544 69753 50132399
Stevens-Johnson syndrome 16.68 10.12 103 402869 21649 50180503
Antinuclear antibody positive 16.68 10.12 96 402876 6176 50195976
Respiration abnormal 16.61 10.12 10 402962 5092 50197060
Dactylitis 16.57 10.12 42 402930 1819 50200333
Coronary artery disease 16.52 10.12 154 402818 29572 50172580
Gastroenteritis viral 16.44 10.12 225 402747 18561 50183591
Pulmonary congestion 16.44 10.12 64 402908 15183 50186969
Immune reconstitution inflammatory syndrome 16.36 10.12 12 402960 5504 50196648
Melaena 16.33 10.12 136 402836 26728 50175424
Gestational hypertension 16.28 10.12 46 402926 2127 50200025
Red blood cell sedimentation rate 16.21 10.12 64 402908 3522 50198630
Infusion site swelling 16.15 10.12 20 402952 7156 50194996
Anger 16.12 10.12 42 402930 11291 50190861
Off label use 16.11 10.12 3436 399536 470990 49731162
Lymphocyte count decreased 16.07 10.12 133 402839 26174 50175978
Lip swelling 16.06 10.12 123 402849 24613 50177539
Foetal growth restriction 16.06 10.12 99 402873 6528 50195624
Hepatotoxicity 16.02 10.12 139 402833 27087 50175065
Myocarditis 16.02 10.12 24 402948 7923 50194229
Injection site warmth 16.01 10.12 175 402797 13691 50188461
Synovial disorder 15.98 10.12 27 402945 873 50201279
Squamous cell carcinoma 15.95 10.12 111 402861 7628 50194524
Colitis microscopic 15.94 10.12 17 402955 6503 50195649
Miosis 15.94 10.12 16 402956 6294 50195858
Maternal exposure timing unspecified 15.87 10.12 64 402908 3556 50198596
Hypoglycaemia neonatal 15.80 10.12 27 402945 881 50201271
Hypertelorism 15.75 10.12 18 402954 399 50201753
Right ventricular failure 15.71 10.12 69 402903 15824 50186328
Hypophagia 15.69 10.12 143 402829 27585 50174567
Swollen tongue 15.62 10.12 149 402823 28481 50173671
Skin cancer 15.56 10.12 128 402844 9266 50192886
Foetal distress syndrome 15.41 10.12 32 402940 1213 50200939
Joint noise 15.40 10.12 63 402909 3524 50198628
Congenital hypertrichosis 15.36 10.12 4 402968 0 50202152
Chondropathy 15.29 10.12 44 402928 2056 50200096
Dysuria 15.27 10.12 149 402823 28355 50173797
Acidosis 15.25 10.12 37 402935 10190 50191962
Hyperprolactinaemia 15.19 10.12 4 402968 3361 50198791
Bradypnoea 15.18 10.12 3 402969 3071 50199081
Vascular device infection 15.12 10.12 8 402964 4376 50197776
Diabetes mellitus 15.12 10.12 287 402685 48746 50153406
Autism spectrum disorder 15.10 10.12 23 402949 680 50201472
Hallucination, auditory 15.08 10.12 40 402932 10688 50191464
Hot flush 15.06 10.12 254 402718 43915 50158237
Crohn's disease 14.99 10.12 76 402896 4657 50197495
Pseudomonas infection 14.96 10.12 33 402939 9397 50192755
Diabetes mellitus inadequate control 14.94 10.12 54 402918 13091 50189061
Mental disorder 14.92 10.12 108 402864 21883 50180269
Dementia 14.89 10.12 71 402901 15926 50186226
Polyuria 14.85 10.12 21 402951 7100 50195052
Immunodeficiency 14.83 10.12 182 402790 14646 50187506
Placental insufficiency 14.79 10.12 32 402940 1249 50200903
Fear of injection 14.68 10.12 91 402881 6012 50196140
Device breakage 14.67 10.12 34 402938 9513 50192639
Jaundice 14.65 10.12 137 402835 26292 50175860
Maternal exposure during breast feeding 14.65 10.12 58 402914 3196 50198956
Renal injury 14.62 10.12 29 402943 8582 50193570
Oliguria 14.53 10.12 27 402945 8189 50193963
Delusion 14.41 10.12 40 402932 10529 50191623
Catheter site pain 14.31 10.12 6 402966 3756 50198396
Toxic epidermal necrolysis 14.29 10.12 103 402869 20889 50181263
Visual impairment 14.28 10.12 424 402548 67851 50134301
Lung adenocarcinoma 14.25 10.12 68 402904 4066 50198086
Twin pregnancy 14.24 10.12 29 402943 1084 50201068
Amniotic fluid volume increased 14.17 10.12 11 402961 146 50202006
Transplant dysfunction 14.14 10.12 10 402962 4674 50197478
Lordosis 14.08 10.12 14 402958 263 50201889
Pharyngitis streptococcal 14.05 10.12 119 402853 8689 50193463
Pericardial effusion 14.03 10.12 133 402839 25456 50176696
Oligohydramnios 14.00 10.12 86 402886 5664 50196488
Angina pectoris 13.99 10.12 137 402835 26051 50176101
Acute myeloid leukaemia 13.97 10.12 67 402905 15007 50187145
Naevus flammeus 13.93 10.12 10 402962 117 50202035
Dislocation of vertebra 13.88 10.12 55 402917 3032 50199120
Infusion site pruritus 13.86 10.12 7 402965 3930 50198222
Retrognathia 13.86 10.12 17 402955 407 50201745
Pain in extremity 13.85 10.12 2422 400550 270443 49931709
Pemphigoid 13.79 10.12 16 402956 5891 50196261
Joint injury 13.75 10.12 247 402725 21542 50180610
Injection site haematoma 13.74 10.12 89 402883 5971 50196181
Human antichimeric antibody positive 13.68 10.12 34 402938 1455 50200697
Disseminated tuberculosis 13.64 10.12 48 402924 2498 50199654
Antibody test positive 13.64 10.12 45 402927 2266 50199886
Product preparation error 13.64 10.12 9 402963 4363 50197789
General physical health deterioration 13.59 10.12 1314 401658 141120 50061032
Treatment noncompliance 13.59 10.12 164 402808 29986 50172166
Anaemia macrocytic 13.50 10.12 48 402924 2511 50199641
Therapy change 13.49 10.12 13 402959 5212 50196940
Drug abuser 13.47 10.12 3 402969 2825 50199327
Cardiotoxicity 13.42 10.12 22 402950 7005 50195147
Cleft palate 13.41 10.12 26 402946 937 50201215
Renal disorder 13.41 10.12 147 402825 27358 50174794
Leukocytosis 13.41 10.12 115 402857 22464 50179688
Personality disorder 13.36 10.12 9 402963 4315 50197837
Pregnancy with contraceptive device 13.27 10.12 8 402964 4071 50198081
Tumour marker increased 13.26 10.12 7 402965 3833 50198319
Autoimmune haemolytic anaemia 13.23 10.12 65 402907 3934 50198218
Salivary hypersecretion 13.19 10.12 20 402952 6571 50195581
Hygroma colli 13.18 10.12 5 402967 12 50202140
Threatened labour 13.17 10.12 23 402949 764 50201388
Myelosuppression 13.17 10.12 59 402913 13458 50188694
Potentiating drug interaction 13.11 10.12 7 402965 3809 50198343
Clostridium difficile colitis 13.10 10.12 85 402887 17657 50184495
Product complaint 13.10 10.12 47 402925 11419 50190733
Multiple-drug resistance 13.07 10.12 5 402967 3309 50198843
Somnambulism 13.00 10.12 12 402960 4912 50197240
Wound infection 12.98 10.12 151 402821 11997 50190155
Sexual dysfunction 12.93 10.12 5 402967 3287 50198865
Subdural haematoma 12.92 10.12 56 402916 12891 50189261
Anuria 12.90 10.12 46 402926 11198 50190954
Joint lock 12.90 10.12 41 402931 2024 50200128
Restless legs syndrome 12.86 10.12 74 402898 15823 50186329
Catheter management 12.86 10.12 3 402969 2736 50199416
Acute generalised exanthematous pustulosis 12.81 10.12 33 402939 8905 50193247
Multiple sclerosis 12.79 10.12 103 402869 20390 50181762
Pyrexia 12.75 10.12 2755 400217 377448 49824704
Haemoptysis 12.74 10.12 136 402836 25437 50176715
Product substitution issue 12.73 10.12 63 402909 13994 50188158
Cyanosis 12.66 10.12 70 402902 15114 50187038
Abdominal pain upper 12.64 10.12 1094 401878 158215 50043937
Occult blood 12.64 10.12 29 402943 1178 50200974
Catatonia 12.62 10.12 7 402965 3729 50198423
Abdominal pain 12.61 10.12 1668 401304 234560 49967592
Corneal degeneration 12.61 10.12 8 402964 75 50202077
Labelled drug-drug interaction medication error 12.61 10.12 42 402930 10435 50191717
Failed induction of labour 12.58 10.12 14 402958 301 50201851
Pulseless electrical activity 12.53 10.12 22 402950 6819 50195333
Bronchopulmonary aspergillosis 12.52 10.12 26 402946 7566 50194586
Laryngospasm 12.51 10.12 3 402969 2685 50199467
Low birth weight baby 12.50 10.12 85 402887 5796 50196356
Pneumonia viral 12.50 10.12 22 402950 6812 50195340
Aphasia 12.46 10.12 156 402816 28338 50173814
Abnormal dreams 12.41 10.12 36 402936 9341 50192811
Klebsiella infection 12.41 10.12 24 402948 7170 50194982
Cerebral infarction 12.40 10.12 111 402861 21493 50180659
Fine motor skill dysfunction 12.38 10.12 65 402907 4038 50198114
Head injury 12.27 10.12 127 402845 23893 50178259
Peripheral sensory neuropathy 12.25 10.12 21 402951 6570 50195582
Tonsillitis 12.22 10.12 74 402898 4849 50197303
Visual acuity reduced 12.22 10.12 102 402870 20037 50182115
Tubulointerstitial nephritis 12.20 10.12 71 402901 15140 50187012
Confusional state 12.19 10.12 1295 401677 184633 50017519
Device issue 12.19 10.12 101 402871 19871 50182281
Poor venous access 12.17 10.12 131 402841 10209 50191943
Breast cancer metastatic 12.16 10.12 42 402930 10322 50191830
Joint warmth 12.15 10.12 31 402941 1348 50200804
Coronary arterial stent insertion 12.14 10.12 3 402969 2631 50199521
Affective disorder 12.13 10.12 14 402958 5167 50196985
Product physical issue 12.11 10.12 10 402962 4322 50197830
Bone lesion 12.07 10.12 14 402958 5156 50196996
Drug screen positive 12.05 10.12 6 402966 3396 50198756
Small cell carcinoma 12.04 10.12 10 402962 147 50202005
Rash erythematous 12.02 10.12 200 402772 34652 50167500
Congenital skin dimples 12.01 10.12 9 402963 113 50202039
Neonatal seizure 11.98 10.12 15 402957 367 50201785
Cervical incompetence 11.96 10.12 19 402953 583 50201569
Human herpesvirus 6 infection 11.95 10.12 3 402969 2603 50199549
Syndactyly 11.95 10.12 14 402958 319 50201833
Lymphoma 11.94 10.12 123 402849 9478 50192674
Toxoplasma serology positive 11.93 10.12 5 402967 17 50202135
Haematoma 11.90 10.12 171 402801 30339 50171813
Hypoplastic left heart syndrome 11.90 10.12 11 402961 188 50201964
Ataxia 11.80 10.12 63 402909 13723 50188429
Anal prolapse 11.78 10.12 8 402964 85 50202067
Body temperature increased 11.76 10.12 177 402795 31164 50170988
Inflammatory marker increased 11.72 10.12 81 402891 5553 50196599
Embedded device 11.67 10.12 4 402968 2833 50199319
Chills 11.66 10.12 640 402332 96047 50106105
Pancreatic steatosis 11.64 10.12 24 402948 905 50201247
Toxic skin eruption 11.64 10.12 48 402924 11203 50190949
Wound infection pseudomonas 11.62 10.12 29 402943 1244 50200908
Hepatic cytolysis 11.55 10.12 30 402942 8073 50194079
Congenital pulmonary artery anomaly 11.52 10.12 3 402969 0 50202152
Double ureter 11.52 10.12 3 402969 0 50202152
Tendonitis 11.49 10.12 192 402780 16513 50185639
Malignant mediastinal neoplasm 11.48 10.12 18 402954 546 50201606
Paranoia 11.44 10.12 43 402929 10305 50191847
Oxygen consumption increased 11.42 10.12 7 402965 3529 50198623
Hereditary angioedema 11.39 10.12 16 402956 5426 50196726
Respiratory acidosis 11.39 10.12 19 402953 6009 50196143
Lymphatic fistula 11.38 10.12 21 402951 729 50201423
Ulcer 11.37 10.12 225 402747 19975 50182177
Hyperthyroidism 11.35 10.12 54 402918 12121 50190031
Congenital cerebral cyst 11.35 10.12 11 402961 200 50201952
Amylase increased 11.33 10.12 16 402956 5414 50196738
Human anti-human antibody test 11.28 10.12 15 402957 390 50201762
Prothrombin consumption time prolonged 11.27 10.12 6 402966 39 50202113
Dialysis 11.24 10.12 38 402934 9400 50192752
Femoral hernia incarcerated 11.16 10.12 21 402951 740 50201412
Bronchitis 11.16 10.12 969 402003 103190 50098962
Throat tightness 11.16 10.12 109 402863 20738 50181414
Congenital tricuspid valve atresia 11.14 10.12 6 402966 40 50202112
Colitis 11.13 10.12 228 402744 38301 50163851
Knee deformity 11.11 10.12 25 402947 1002 50201150
Cardiac disorder 11.07 10.12 259 402713 42720 50159432
Generalised oedema 11.07 10.12 64 402908 13667 50188485
Paraesthesia 11.04 10.12 816 402156 119427 50082725
Full blood count abnormal 11.01 10.12 126 402846 23262 50178890
Aphthous ulcer 11.00 10.12 131 402841 10466 50191686
Teratoma benign 11 10.12 7 402965 66 50202086
Taste disorder 10.98 10.12 32 402940 8292 50193860
Hypernatraemia 10.98 10.12 21 402951 6300 50195852
Cleft lip and palate 10.98 10.12 14 402958 349 50201803
Neonatal infection 10.97 10.12 9 402963 130 50202022
Food allergy 10.94 10.12 31 402941 8106 50194046
Bone disorder 10.94 10.12 210 402762 18542 50183610
Amniotic fluid volume decreased 10.91 10.12 16 402956 457 50201695
Pulmonary haemorrhage 10.90 10.12 22 402950 6470 50195682
Sinus bradycardia 10.87 10.12 61 402911 13122 50189030
Myoclonus 10.85 10.12 69 402903 14401 50187751
Cardiomyopathy 10.84 10.12 76 402896 15510 50186642
Abortion induced 10.82 10.12 118 402854 9226 50192926
Eating disorder 10.79 10.12 75 402897 15334 50186818
Toxic encephalopathy 10.78 10.12 17 402955 5498 50196654
Tendon disorder 10.77 10.12 76 402896 5246 50196906
Rebound effect 10.74 10.12 6 402966 3183 50198969
Psychomotor hyperactivity 10.71 10.12 38 402934 9263 50192889
Anterior chamber cleavage syndrome 10.67 10.12 10 402962 174 50201978
Neonatal hypoxia 10.66 10.12 16 402956 467 50201685
Lymphadenectomy 10.57 10.12 23 402949 901 50201251
Ingrown hair 10.51 10.12 16 402956 473 50201679
Plasma cell myeloma recurrent 10.50 10.12 4 402968 2654 50199498
Ankylosing spondylitis 10.49 10.12 95 402877 7070 50195082
Hypotonia neonatal 10.49 10.12 24 402948 973 50201179
Congenital oesophageal anomaly 10.43 10.12 4 402968 10 50202142
Systemic inflammatory response syndrome 10.42 10.12 15 402957 5034 50197118
Foot fracture 10.39 10.12 221 402751 19870 50182282
Renal aplasia 10.36 10.12 11 402961 224 50201928
Rheumatoid lung 10.35 10.12 43 402929 2422 50199730
Polydipsia 10.34 10.12 6 402966 3118 50199034
Application site pain 10.34 10.12 9 402963 3789 50198363
Limb reduction defect 10.27 10.12 14 402958 373 50201779
Forceps delivery 10.27 10.12 10 402962 183 50201969
Purging 10.24 10.12 6 402966 48 50202104
Chronic graft versus host disease 10.24 10.12 5 402967 2862 50199290
Selective eating disorder 10.22 10.12 35 402937 1797 50200355
Eosinophil count increased 10.22 10.12 36 402936 8794 50193358
Congenital oral malformation 10.18 10.12 10 402962 185 50201967
Ventricular hypoplasia 10.17 10.12 9 402963 145 50202007
Haematocrit decreased 10.15 10.12 357 402615 34619 50167533
Crystal nephropathy 10.15 10.12 21 402951 794 50201358
Renal mass 10.14 10.12 36 402936 1882 50200270

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 744.71 10.12 908 155931 32959 29384729
Rheumatoid arthritis 479.97 10.12 714 156125 31438 29386250
Drug abuse 331.24 10.12 24 156815 79859 29337829
Toxicity to various agents 279.01 10.12 306 156533 173355 29244333
Completed suicide 245.46 10.12 86 156753 90160 29327528
Dysmorphism 197.10 10.12 147 156692 2824 29414864
Atrial septal defect 192.92 10.12 208 156631 6581 29411107
Arthralgia 175.47 10.12 1304 155535 138313 29279375
Hypospadias 163.17 10.12 132 156707 2870 29414818
Premature baby 159.59 10.12 310 156529 16970 29400718
Small for dates baby 144.97 10.12 133 156706 3446 29414242
Psoriatic arthropathy 138.66 10.12 266 156573 14425 29403263
Speech disorder developmental 114.69 10.12 89 156750 1818 29415870
Ventricular septal defect 114.36 10.12 116 156723 3413 29414275
Sickle cell anaemia with crisis 111.68 10.12 100 156739 2508 29415180
Death 106.09 10.12 1233 155606 340851 29076837
Maternal exposure during pregnancy 99.46 10.12 116 156723 4007 29413681
Cryptorchism 98.44 10.12 82 156757 1860 29415828
Drug interaction 96.94 10.12 631 156208 196754 29220934
Foetal anticonvulsant syndrome 96.57 10.12 66 156773 1098 29416590
Neonatal respiratory distress syndrome 94.94 10.12 109 156730 3701 29413987
Intentional overdose 92.84 10.12 44 156795 38484 29379204
Psoriasis 89.93 10.12 374 156465 31853 29385835
Congenital umbilical hernia 88.25 10.12 39 156800 254 29417434
Joint swelling 86.82 10.12 504 156335 49126 29368562
Enthesopathy 83.19 10.12 101 156738 3642 29414046
Pancytopenia 82.73 10.12 737 156102 82431 29335257
Autism spectrum disorder 81.30 10.12 75 156764 1957 29415731
Low birth weight baby 78.13 10.12 132 156707 6476 29411212
Respiratory disorder neonatal 76.06 10.12 62 156777 1363 29416325
Exposure during pregnancy 75.99 10.12 151 156688 8403 29409285
Hypoglycaemia neonatal 75.60 10.12 67 156772 1657 29416031
Learning disorder 71.01 10.12 52 156787 970 29416718
Tenosynovitis 70.69 10.12 93 156746 3640 29414048
Maternal drugs affecting foetus 70.67 10.12 95 156744 3798 29413890
Agitation neonatal 69.49 10.12 52 156787 1004 29416684
Hypotonia neonatal 68.44 10.12 55 156784 1184 29416504
Developmental delay 66.08 10.12 74 156765 2444 29415244
Talipes 65.68 10.12 63 156776 1729 29415959
Foot deformity 65.41 10.12 93 156746 3922 29413766
Musculoskeletal stiffness 63.94 10.12 378 156461 37080 29380608
Syndactyly 62.07 10.12 43 156796 732 29416956
Suicide attempt 58.11 10.12 57 156782 34053 29383635
Renal aplasia 55.81 10.12 38 156801 628 29417060
Language disorder 55.61 10.12 60 156779 1899 29415789
Blood pressure fluctuation 54.03 10.12 229 156610 19665 29398023
Overdose 53.12 10.12 230 156609 79589 29338099
Drug resistance 52.81 10.12 24 156815 21516 29396172
Intellectual disability 51.48 10.12 45 156794 1092 29416596
Nasopharyngitis 51.43 10.12 513 156326 59152 29358536
Synovitis 50.95 10.12 150 156689 10740 29406948
Drug reaction with eosinophilia and systemic symptoms 49.77 10.12 45 156794 27947 29389741
Rhabdomyolysis 49.03 10.12 162 156677 60646 29357042
Serotonin syndrome 48.75 10.12 16 156823 17496 29400192
Product use in unapproved indication 48.18 10.12 267 156572 86608 29331080
Drug dependence 47.49 10.12 26 156813 20955 29396733
Rheumatoid nodule 46.74 10.12 57 156782 2065 29415623
Febrile neutropenia 46.66 10.12 376 156463 111864 29305824
Joint laxity 46.63 10.12 28 156811 368 29417320
Coma 45.92 10.12 87 156752 39363 29378325
Drug withdrawal syndrome neonatal 45.81 10.12 72 156767 3323 29414365
Palmar-plantar erythrodysaesthesia syndrome 45.70 10.12 11 156828 14748 29402940
Selective eating disorder 45.58 10.12 50 156789 1613 29416075
Maternal exposure during breast feeding 44.82 10.12 47 156792 1439 29416249
Hepatic function abnormal 44.46 10.12 88 156751 39171 29378517
Exposure via breast milk 44.39 10.12 50 156789 1662 29416026
Foetal growth restriction 44.22 10.12 75 156764 3691 29413997
Basal cell carcinoma 43.88 10.12 192 156647 16718 29400970
Intentional product misuse 43.44 10.12 73 156766 34588 29383100
Hyperbilirubinaemia neonatal 43.26 10.12 34 156805 708 29416980
Nasal disorder 42.23 10.12 45 156794 1404 29416284
C-reactive protein abnormal 41.69 10.12 101 156738 6435 29411253
Tongue disorder 41.37 10.12 82 156757 4554 29413134
Hypertonia neonatal 41.28 10.12 26 156813 374 29417314
Behaviour disorder 41.12 10.12 71 156768 3545 29414143
Dysgraphia 40.50 10.12 52 156787 1986 29415702
Bradycardia neonatal 40.16 10.12 36 156803 904 29416784
Hypertelorism 40.10 10.12 29 156810 530 29417158
Large for dates baby 39.95 10.12 35 156804 852 29416836
Pain 39.75 10.12 1190 155649 170242 29247446
Constipation 38.13 10.12 404 156435 113756 29303932
Motor developmental delay 37.96 10.12 30 156809 630 29417058
General physical health deterioration 37.69 10.12 760 156079 102097 29315591
Patent ductus arteriosus 37.62 10.12 63 156776 3068 29414620
Disease progression 37.54 10.12 267 156572 81649 29336039
Drug withdrawal syndrome 36.92 10.12 25 156814 17959 29399729
Birth mark 36.90 10.12 18 156821 151 29417537
Pulmonary fibrosis 36.75 10.12 172 156667 15410 29402278
Ear disorder 36.13 10.12 39 156800 1235 29416453
Strabismus 36.11 10.12 41 156798 1375 29416313
Haemangioma congenital 36.06 10.12 26 156813 473 29417215
Plagiocephaly 35.92 10.12 26 156813 476 29417212
Psychomotor retardation 35.92 10.12 60 156779 2916 29414772
Arthritis 35.56 10.12 241 156598 24778 29392910
Suicidal ideation 34.22 10.12 84 156755 34632 29383056
Congenital hydronephrosis 34.22 10.12 29 156810 674 29417014
Hypermobility syndrome 33.80 10.12 22 156817 336 29417352
Osteoarthritis 33.71 10.12 187 156652 17916 29399772
Caesarean section 33.50 10.12 46 156793 1877 29415811
Renal failure 33.32 10.12 436 156403 118163 29299525
Off label use 32.86 10.12 1284 155555 299516 29118172
Congenital hand malformation 32.54 10.12 26 156813 555 29417133
Bronchiolitis 32.52 10.12 55 156784 2700 29414988
Pectus excavatum 32.19 10.12 18 156821 205 29417483
Respiratory arrest 31.82 10.12 55 156784 25778 29391910
Spina bifida 31.59 10.12 21 156818 333 29417355
Sedation 30.92 10.12 28 156811 17377 29400311
Polydactyly 30.77 10.12 34 156805 1106 29416582
Bradycardia 30.51 10.12 213 156626 65416 29352272
Arthropathy 30.26 10.12 207 156632 21347 29396341
Abnormal palmar/plantar creases 29.93 10.12 17 156822 200 29417488
Attention deficit hyperactivity disorder 29.89 10.12 47 156792 2170 29415518
Jaundice neonatal 29.73 10.12 35 156804 1221 29416467
Astigmatism 29.67 10.12 31 156808 945 29416743
Cardiac arrest 29.34 10.12 301 156538 85290 29332398
Joint effusion 29.24 10.12 67 156772 4117 29413571
Urticaria 29.20 10.12 170 156669 54490 29363198
Knee deformity 29.08 10.12 24 156815 537 29417151
Blood creatine phosphokinase increased 28.96 10.12 114 156725 40530 29377158
Kidney duplex 28.89 10.12 21 156818 387 29417301
Agitation 28.79 10.12 157 156682 51147 29366541
Altered state of consciousness 28.70 10.12 38 156801 19851 29397837
Delirium 28.39 10.12 110 156729 39287 29378401
Otitis media 28.36 10.12 50 156789 2539 29415149
Poisoning 28.04 10.12 9 156830 9984 29407704
Angioedema 27.85 10.12 82 156757 31833 29385855
Low set ears 27.60 10.12 21 156818 416 29417272
Blood pressure systolic increased 27.46 10.12 168 156671 16677 29401011
Pathogen resistance 27.28 10.12 5 156834 8111 29409577
Single umbilical artery 27.27 10.12 16 156823 201 29417487
Alanine aminotransferase abnormal 27.23 10.12 53 156786 2904 29414784
Hydrocele 27.16 10.12 42 156797 1911 29415777
Dyspraxia 26.95 10.12 20 156819 381 29417307
Congenital tricuspid valve incompetence 26.86 10.12 14 156825 137 29417551
Blood pressure systolic abnormal 26.66 10.12 44 156795 2117 29415571
C-reactive protein increased 26.63 10.12 355 156484 43908 29373780
Neuroleptic malignant syndrome 26.35 10.12 28 156811 16120 29401568
Serum ferritin increased 26.17 10.12 77 156762 5511 29412177
Cleft lip and palate 26.05 10.12 18 156821 305 29417383
Tendonitis 25.92 10.12 97 156742 7864 29409824
Hyperglycaemia 25.84 10.12 94 156745 34193 29383495
Ear infection 25.80 10.12 98 156741 8002 29409686
Haemoglobin decreased 25.54 10.12 754 156085 107621 29310067
Electrocardiogram QT prolonged 25.34 10.12 102 156737 36035 29381653
Polyarthritis 25.20 10.12 61 156778 3884 29413804
Drug intolerance 25.09 10.12 378 156461 48001 29369687
Microcephaly 24.94 10.12 25 156814 725 29416963
Lower respiratory tract infection 24.85 10.12 232 156607 26270 29391418
Scoliosis 24.65 10.12 44 156795 2256 29415432
Medical device implantation 24.53 10.12 22 156817 553 29417135
Developmental coordination disorder 24.20 10.12 14 156825 171 29417517
Congenital knee deformity 24.17 10.12 12 156827 105 29417583
Foetal disorder 24.03 10.12 25 156814 758 29416930
Somnolence 24.01 10.12 352 156487 93603 29324085
Fine motor skill dysfunction 23.91 10.12 35 156804 1516 29416172
Anal fistula 23.80 10.12 62 156777 4133 29413555
Neonatal seizure 23.63 10.12 20 156819 464 29417224
Psychotic disorder 23.58 10.12 45 156794 20309 29397379
Infusion related reaction 23.58 10.12 345 156494 43541 29374147
Musculoskeletal pain 23.52 10.12 246 156593 28707 29388981
Weight decrease neonatal 23.26 10.12 17 156822 316 29417372
Congenital astigmatism 23.24 10.12 8 156831 23 29417665
Substance abuse 23.21 10.12 4 156835 6783 29410905
Hand deformity 23.15 10.12 41 156798 2089 29415599
Folate deficiency 22.99 10.12 29 156810 1088 29416600
Tuberculosis 22.86 10.12 87 156752 7109 29410579
Skin cancer 22.62 10.12 97 156742 8371 29409317
Dermatitis psoriasiform 22.56 10.12 29 156810 1109 29416579
Cleft palate 22.29 10.12 21 156818 563 29417125
Educational problem 22.16 10.12 20 156819 507 29417181
Ectopic kidney 22.07 10.12 8 156831 28 29417660
Knee arthroplasty 21.66 10.12 74 156765 5735 29411953
Acute kidney injury 21.51 10.12 1169 155670 264098 29153590
Sopor 21.39 10.12 16 156823 10918 29406770
Enuresis 21.23 10.12 39 156800 2045 29415643
Dyslexia 21.07 10.12 16 156823 316 29417372
Shock 20.93 10.12 52 156787 21352 29396336
Prognathism 20.65 10.12 11 156828 113 29417575
Infective pulmonary exacerbation of cystic fibrosis 20.62 10.12 4 156835 6232 29411456
Wrong technique in product usage process 20.62 10.12 91 156748 31337 29386351
Ankyloglossia congenital 20.38 10.12 15 156824 282 29417406
Vitamin B12 deficiency 20.28 10.12 50 156789 3221 29414467
Vitamin D deficiency 20.24 10.12 70 156769 5459 29412229
Hepatic failure 20.22 10.12 92 156747 31420 29386268
Unresponsive to stimuli 20.20 10.12 67 156772 25059 29392629
Congenital myopia 20.19 10.12 9 156830 60 29417628
Wound 20.10 10.12 121 156718 11942 29405746
Pyelocaliectasis 20.03 10.12 27 156812 1082 29416606
Pain in extremity 20.03 10.12 745 156094 109688 29308000
Clinodactyly 19.98 10.12 14 156825 243 29417445
Joint range of motion decreased 19.90 10.12 74 156765 5980 29411708
Hallucination 19.86 10.12 147 156692 44565 29373123
Depressed level of consciousness 19.67 10.12 115 156724 36827 29380861
Pyloric stenosis 19.61 10.12 22 156817 728 29416960
Hypoglycaemia 19.59 10.12 163 156676 48183 29369505
Pulmonary artery stenosis congenital 19.56 10.12 18 156821 468 29417220
Foetal heart rate deceleration abnormality 19.47 10.12 18 156821 471 29417217
Product quality issue 19.43 10.12 34 156805 15861 29401827
Respiratory failure 19.26 10.12 381 156458 96750 29320938
Congenital bladder anomaly 19.22 10.12 14 156825 259 29417429
Strabismus congenital 19.21 10.12 7 156832 25 29417663
Acute hepatic failure 19.19 10.12 21 156818 11931 29405757
Limb reduction defect 19.17 10.12 14 156825 260 29417428
Congenital anomaly 19.09 10.12 29 156810 1299 29416389
No adverse event 19.08 10.12 40 156799 17438 29400250
Psychomotor skills impaired 19.03 10.12 43 156796 2618 29415070
Oesophageal fibrosis 18.97 10.12 12 156827 174 29417514
Inguinal hernia 18.94 10.12 78 156761 6610 29411078
Kinematic imbalances due to suboccipital strain 18.94 10.12 6 156833 12 29417676
Malignant neoplasm progression 18.76 10.12 277 156562 73582 29344106
Loss of personal independence in daily activities 18.75 10.12 212 156627 25228 29392460
Floppy infant 18.75 10.12 10 156829 103 29417585
Cytomegalovirus infection 18.60 10.12 62 156777 23153 29394535
Neonatal respiratory distress 18.59 10.12 18 156821 500 29417188
Congenital foot malformation 18.42 10.12 16 156823 385 29417303
Multiple congenital abnormalities 18.41 10.12 18 156821 506 29417182
Blood pressure increased 18.34 10.12 517 156322 73286 29344402
Red blood cell sedimentation rate increased 18.06 10.12 83 156756 7378 29410310
Blood pressure diastolic abnormal 17.99 10.12 41 156798 2510 29415178
Bronchial carcinoma 17.86 10.12 23 156816 881 29416807
Kyphosis congenital 17.79 10.12 5 156834 5 29417683
Epispadias 17.72 10.12 11 156828 154 29417534
Ear malformation 17.67 10.12 14 156825 295 29417393
Hypermetropia 17.58 10.12 16 156823 410 29417278
Body temperature decreased 17.16 10.12 106 156733 10558 29407130
Arthritis bacterial 17.15 10.12 57 156782 4356 29413332
Prominent epicanthal folds 17.13 10.12 11 156828 164 29417524
Lacrimal disorder 17.13 10.12 14 156825 309 29417379
Post procedural infection 17.08 10.12 56 156783 4249 29413439
Tooth malformation 17.07 10.12 11 156828 165 29417523
Cleft lip 17.01 10.12 14 156825 312 29417376
Multiple organ dysfunction syndrome 16.99 10.12 234 156605 62882 29354806
Hernia congenital 16.98 10.12 4 156835 0 29417688
Colitis ulcerative 16.96 10.12 121 156718 12648 29405040
Lung neoplasm malignant 16.78 10.12 132 156707 14225 29403463
Prostate cancer 16.73 10.12 208 156631 25319 29392369
Juvenile idiopathic arthritis 16.68 10.12 28 156811 1366 29416322
Crohn's disease 16.59 10.12 44 156795 2965 29414723
Diabetic ketoacidosis 16.55 10.12 38 156801 16035 29401653
Pseudolymphoma 16.49 10.12 17 156822 510 29417178
Neurotoxicity 16.33 10.12 33 156806 14580 29403108
Camptodactyly congenital 16.21 10.12 9 156830 101 29417587
Grip strength decreased 16.18 10.12 37 156802 2270 29415418
Blood pressure diastolic decreased 16.18 10.12 77 156762 6945 29410743
Immunosuppression 16.05 10.12 63 156776 5223 29412465
Fine motor delay 15.98 10.12 12 156827 233 29417455
Accessory spleen 15.93 10.12 10 156829 143 29417545
Micropenis 15.92 10.12 7 156832 45 29417643
Maternal exposure before pregnancy 15.85 10.12 16 156823 468 29417220
Microphthalmos 15.84 10.12 11 156828 188 29417500
Diverticular perforation 15.81 10.12 43 156796 2941 29414747
Joint stiffness 15.77 10.12 95 156744 9378 29408310
Heart disease congenital 15.71 10.12 26 156813 1254 29416434
Peripheral swelling 15.70 10.12 446 156393 63293 29354395
Toxic epidermal necrolysis 15.58 10.12 47 156792 18106 29399582
Respiratory depression 15.58 10.12 30 156809 13493 29404195
Spinal disorder 15.51 10.12 49 156790 3646 29414042
Neck mass 15.45 10.12 28 156811 1453 29416235
Malignant melanoma 15.41 10.12 77 156762 7084 29410604
Lower respiratory tract congestion 15.36 10.12 23 156816 1017 29416671
Inflammation 15.24 10.12 186 156653 22542 29395146
Poor sucking reflex 15.20 10.12 13 156826 306 29417382
Haemangioma 15.16 10.12 30 156809 1664 29416024
Cerebral haemorrhage neonatal 15.10 10.12 12 156827 254 29417434
Venoocclusive liver disease 15.04 10.12 9 156830 6908 29410780
Renal impairment 14.95 10.12 323 156516 81010 29336678
Diaphragmatic disorder 14.91 10.12 22 156817 960 29416728
Hepatic cyst 14.91 10.12 36 156803 2289 29415399
Hypotension 14.90 10.12 861 155978 193493 29224195
Haematocrit decreased 14.75 10.12 226 156613 28796 29388892
Arthrodesis 14.74 10.12 15 156824 443 29417245
Oropharyngeal discomfort 14.73 10.12 38 156801 2518 29415170
Congenital cerebral cyst 14.62 10.12 5 156834 14 29417674
C-reactive protein decreased 14.53 10.12 28 156811 1523 29416165
Congenital megaureter 14.50 10.12 9 156830 126 29417562
Hypoxia 14.48 10.12 171 156668 47208 29370480
Coarctation of the aorta 14.44 10.12 15 156824 454 29417234
Kyphosis 14.36 10.12 23 156816 1079 29416609
Oesophageal atresia 14.34 10.12 15 156824 458 29417230
Drug ineffective for unapproved indication 14.32 10.12 34 156805 14180 29403508
Cerebral ventricle dilatation 14.31 10.12 20 156819 830 29416858
Umbilical hernia 14.30 10.12 48 156791 3687 29414001
Anal atresia 14.26 10.12 12 156827 276 29417412
Incorrect route of product administration 14.23 10.12 22 156817 10779 29406909
Developmental hip dysplasia 14.16 10.12 12 156827 279 29417409
Septic arthritis staphylococcal 14.07 10.12 15 156824 468 29417220
Oesophageal adenocarcinoma 14.01 10.12 19 156820 766 29416922
Hydrops foetalis 14.00 10.12 11 156828 229 29417459
Abnormal labour affecting foetus 13.91 10.12 5 156834 17 29417671
Brain stem auditory evoked response abnormal 13.91 10.12 5 156834 17 29417671
Emphysema 13.83 10.12 86 156753 8585 29409103
Peritoneal tuberculosis 13.82 10.12 13 156826 348 29417340
Pulmonary valve stenosis 13.82 10.12 13 156826 348 29417340
Blood pressure diastolic increased 13.78 10.12 47 156792 3639 29414049
Finger deformity 13.78 10.12 23 156816 1117 29416571
Infantile apnoea 13.69 10.12 20 156819 865 29416823
Latent tuberculosis 13.66 10.12 22 156817 1037 29416651
Micrognathia 13.57 10.12 12 156827 296 29417392
Encopresis 13.52 10.12 9 156830 143 29417545
Sexual dysfunction 13.46 10.12 7 156832 5807 29411881
Neutropenia neonatal 13.43 10.12 17 156822 640 29417048
Maternal exposure timing unspecified 13.43 10.12 13 156826 361 29417327
Vomiting 13.41 10.12 957 155882 211303 29206385
Neuropathy peripheral 13.36 10.12 281 156558 70746 29346942
Temperature regulation disorder 13.33 10.12 16 156823 570 29417118
Mean cell volume increased 13.32 10.12 36 156803 2453 29415235
Intentional self-injury 13.20 10.12 29 156810 12432 29405256
Arnold-Chiari malformation 13.17 10.12 12 156827 308 29417380
Congenital mitral valve incompetence 13.07 10.12 8 156831 109 29417579
Obsessive-compulsive disorder 13.06 10.12 4 156835 4572 29413116
Haemolysis 13.04 10.12 72 156767 6884 29410804
Hernia pain 13.00 10.12 11 156828 255 29417433
Therapeutic product effect decreased 12.98 10.12 224 156615 29227 29388461
Lung cancer metastatic 12.89 10.12 35 156804 2392 29415296
Ankylosing spondylitis 12.87 10.12 50 156789 4126 29413562
Hyperammonaemia 12.84 10.12 7 156832 5656 29412032
Proteinuria 12.80 10.12 42 156797 15762 29401926
Cardio-respiratory arrest 12.77 10.12 190 156649 50411 29367277
Immunodeficiency 12.75 10.12 52 156787 4388 29413300
Umbilical granuloma 12.73 10.12 3 156836 0 29417688
Gross motor delay 12.72 10.12 11 156828 263 29417425
Dactylitis 12.69 10.12 17 156822 677 29417011
Back disorder 12.69 10.12 64 156775 5909 29411779
Heart rate decreased 12.66 10.12 194 156645 24718 29392970
Bursitis 12.64 10.12 55 156784 4777 29412911
Glycosylated haemoglobin increased 12.61 10.12 19 156820 9407 29408281
Aspergillus infection 12.60 10.12 23 156816 10558 29407130
Weight decreased 12.60 10.12 946 155893 149959 29267729
Stevens-Johnson syndrome 12.58 10.12 45 156794 16452 29401236
Poikiloderma 12.56 10.12 9 156830 162 29417526
Mouth ulceration 12.54 10.12 96 156743 10259 29407429
Cystitis haemorrhagic 12.50 10.12 5 156834 4837 29412851
Meningeal disorder 12.46 10.12 12 156827 331 29417357
Communication disorder 12.45 10.12 34 156805 2331 29415357
Suspected suicide 12.44 10.12 3 156836 4017 29413671
Acquired plagiocephaly 12.44 10.12 6 156833 49 29417639
Visuospatial deficit 12.42 10.12 7 156832 81 29417607
Pleural fibrosis 12.38 10.12 24 156815 1311 29416377
Vascular insufficiency 12.37 10.12 12 156827 334 29417354
Cardiac failure 12.32 10.12 323 156516 78964 29338724
Squamous cell carcinoma of lung 12.32 10.12 27 156812 1610 29416078
Duodenal atresia 12.31 10.12 4 156835 9 29417679
Pharyngeal disorder 12.26 10.12 16 156823 621 29417067
Pyrexia 12.25 10.12 1337 155502 286285 29131403
Myopia 12.21 10.12 20 156819 956 29416732
Radiation inflammation 12.18 10.12 10 156829 222 29417466
Cholelithiasis 12.17 10.12 152 156687 18520 29399168
Nausea 12.00 10.12 1347 155492 287908 29129780
Blood insulin increased 12.00 10.12 12 156827 347 29417341
Meconium in amniotic fluid 11.94 10.12 5 156834 28 29417660
Ligament laxity 11.94 10.12 5 156834 28 29417660
Cytogenetic abnormality 11.94 10.12 18 156821 801 29416887
BK virus infection 11.92 10.12 5 156834 4702 29412986
Congenital eye disorder 11.92 10.12 8 156831 129 29417559
Erectile dysfunction 11.90 10.12 52 156787 17957 29399731
Akinesia 11.90 10.12 30 156809 1960 29415728
Foetal distress syndrome 11.87 10.12 20 156819 979 29416709
Blood parathyroid hormone decreased 11.85 10.12 18 156821 806 29416882
Lordosis 11.85 10.12 10 156829 231 29417457
Respiratory rate increased 11.85 10.12 83 156756 8625 29409063
Iron deficiency 11.84 10.12 39 156800 2966 29414722
Pulmonary valve stenosis congenital 11.81 10.12 8 156831 131 29417557
Muscle spasms 11.80 10.12 259 156580 64823 29352865
Placental insufficiency 11.72 10.12 7 156832 91 29417597
Joint contracture 11.68 10.12 28 156811 1772 29415916
Peripheral artery thrombosis 11.67 10.12 31 156808 2091 29415597
Myalgia 11.64 10.12 301 156538 73718 29343970
Poor venous access 11.55 10.12 40 156799 3121 29414567
Nose deformity 11.55 10.12 9 156830 185 29417503
Tonsil cancer 11.54 10.12 19 156820 912 29416776
Palindromic rheumatism 11.51 10.12 9 156830 186 29417502
Skin indentation 11.50 10.12 4 156835 12 29417676
Foetal hypokinesia 11.48 10.12 12 156827 366 29417322
Laryngomalacia 11.46 10.12 11 156828 302 29417386
Craniosynostosis 11.46 10.12 11 156828 302 29417386
Learning disability 11.32 10.12 11 156828 307 29417381
Gangrene neonatal 11.27 10.12 9 156830 192 29417496
Abnormal behaviour 11.27 10.12 74 156765 23053 29394635
Gastric haemorrhage 11.26 10.12 20 156819 9277 29408411
Irritability 11.24 10.12 70 156769 22082 29395606
Acute chest syndrome 11.23 10.12 11 156828 310 29417378
Steatorrhoea 11.19 10.12 16 156823 678 29417010
Pallor 11.18 10.12 165 156674 20859 29396829
Haptoglobin decreased 11.16 10.12 14 156825 522 29417166
Thinking abnormal 11.12 10.12 7 156832 5229 29412459
Hypotony maculopathy 11.04 10.12 4 156835 14 29417674
Congenital cystic kidney disease 10.99 10.12 12 156827 385 29417303
Scleroderma renal crisis 10.98 10.12 7 156832 103 29417585
Therapy partial responder 10.98 10.12 7 156832 5192 29412496
Lipase increased 10.97 10.12 17 156822 8320 29409368
Oxygen saturation decreased 10.94 10.12 314 156525 44623 29373065
Excessive cerumen production 10.93 10.12 10 156829 258 29417430
Scleroedema 10.89 10.12 5 156834 36 29417652
Congenital aortic valve incompetence 10.89 10.12 8 156831 150 29417538
Muscle tone disorder 10.84 10.12 8 156831 151 29417537
Adenomatous polyposis coli 10.84 10.12 8 156831 151 29417537
Adenovirus infection 10.83 10.12 5 156834 4442 29413246
Autosomal chromosome anomaly 10.83 10.12 4 156835 15 29417673
Intestinal stenosis 10.81 10.12 28 156811 1860 29415828
Red blood cell sedimentation rate 10.80 10.12 14 156825 540 29417148
Potentiating drug interaction 10.79 10.12 5 156834 4433 29413255
Dermatitis acneiform 10.79 10.12 8 156831 5483 29412205
Reticulocytosis 10.77 10.12 10 156829 263 29417425
Congenital torticollis 10.76 10.12 6 156833 68 29417620
High arched palate 10.76 10.12 6 156833 68 29417620
Status epilepticus 10.73 10.12 26 156813 10768 29406920
Neurodevelopmental disorder 10.70 10.12 11 156828 329 29417359
Neuroendocrine tumour of the lung metastatic 10.69 10.12 7 156832 108 29417580
Gastrooesophageal sphincter insufficiency 10.68 10.12 6 156833 69 29417619
Ultrasound antenatal screen 10.67 10.12 3 156836 3 29417685
Urinary tract malformation 10.67 10.12 3 156836 3 29417685
Akathisia 10.66 10.12 12 156827 6730 29410958
Neonatal infection 10.60 10.12 12 156827 401 29417287
Oropharyngeal pain 10.57 10.12 216 156623 29069 29388619
Arthritis infective 10.55 10.12 36 156803 2788 29414900
Granuloma skin 10.54 10.12 15 156824 633 29417055
Peritoneal dialysis complication 10.53 10.12 25 156814 1572 29416116
Personal relationship issue 10.53 10.12 10 156829 271 29417417
Hypotelorism of orbit 10.48 10.12 7 156832 112 29417576
Depression 10.47 10.12 358 156481 84789 29332899
Paranoia 10.45 10.12 23 156816 9854 29407834
Foetal heart rate abnormal 10.45 10.12 8 156831 160 29417528
Pulmonary tuberculosis 10.44 10.12 48 156791 4267 29413421
Congenital melanocytic naevus 10.44 10.12 4 156835 17 29417671
Anaphylactic shock 10.42 10.12 36 156803 13300 29404388
Neonatal hyponatraemia 10.39 10.12 6 156833 73 29417615
Body dysmorphic disorder 10.37 10.12 7 156832 114 29417574
Dysgeusia 10.33 10.12 74 156765 22600 29395088
Anaemia vitamin B12 deficiency 10.32 10.12 10 156829 278 29417410
Fracture 10.27 10.12 61 156778 5992 29411696
Aorticopulmonary septal defect 10.26 10.12 4 156835 18 29417670
Reticulocyte count increased 10.24 10.12 13 156826 491 29417197
Brain oedema 10.23 10.12 32 156807 12188 29405500
Tachycardia 10.21 10.12 299 156540 72111 29345577
Aplasia cutis congenita 10.16 10.12 7 156832 118 29417570
Hospitalisation 10.16 10.12 177 156662 45811 29371877
JC virus CSF test positive 10.16 10.12 7 156832 118 29417570
Transplant rejection 10.13 10.12 21 156818 9191 29408497

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1201.69 9.79 3045 419689 161249 63914749
Completed suicide 978.18 9.79 151 422583 224263 63851735
Toxicity to various agents 776.95 9.79 743 421991 362770 63713228
Pemphigus 736.65 9.79 1381 421353 59320 64016678
Systemic lupus erythematosus 713.95 9.79 1574 421160 76038 63999960
Arthropathy 711.33 9.79 2070 420664 118897 63957101
Hand deformity 679.76 9.79 1361 421373 61410 64014588
Maternal exposure during pregnancy 677.31 9.79 1755 420979 94129 63981869
Joint swelling 676.97 9.79 3001 419733 212381 63863617
Synovitis 651.54 9.79 1766 420968 97324 63978674
Drug abuse 622.15 9.79 70 422664 132304 63943694
Glossodynia 610.80 9.79 1326 421408 63370 64012628
Arthralgia 575.36 9.79 4899 417835 437361 63638637
Infusion related reaction 526.59 9.79 2305 420429 162162 63913836
Anti-cyclic citrullinated peptide antibody positive 503.82 9.79 1047 421687 48515 64027483
Wound 501.60 9.79 1362 421372 75115 64000883
Pericarditis 482.83 9.79 1184 421550 61332 64014666
Exposure during pregnancy 452.29 9.79 1325 421409 76350 63999648
Death 407.25 9.79 1705 421029 481000 63594998
Pain 391.27 9.79 5429 417305 548082 63527916
Abdominal discomfort 373.94 9.79 2256 420478 180066 63895932
Alopecia 360.24 9.79 2082 420652 163608 63912390
Therapeutic product effect decreased 348.88 9.79 1590 421144 113761 63962237
Swelling 339.06 9.79 1999 420735 158219 63917779
Discomfort 336.84 9.79 1231 421503 79647 63996351
Nasopharyngitis 336.28 9.79 2319 420415 193754 63882244
Contraindicated product administered 326.59 9.79 1487 421247 106342 63969656
Intentional overdose 307.10 9.79 103 422631 89841 63986157
Rheumatoid factor positive 298.12 9.79 688 422046 34250 64041748
Duodenal ulcer perforation 292.33 9.79 679 422055 33946 64042052
Helicobacter infection 286.04 9.79 717 422017 37645 64038353
Musculoskeletal stiffness 277.40 9.79 1563 421171 121643 63954355
Drug intolerance 266.26 9.79 2125 420609 185867 63890131
Hepatic enzyme increased 259.97 9.79 1598 421136 128345 63947653
Drug interaction 254.42 9.79 1365 421369 360718 63715280
Gestational diabetes 232.88 9.79 232 422502 5358 64070640
Psoriatic arthropathy 222.53 9.79 707 422027 42574 64033424
Febrile neutropenia 218.24 9.79 575 422159 187082 63888916
C-reactive protein abnormal 209.35 9.79 536 422198 28511 64047487
Cardiac arrest 199.69 9.79 446 422288 153618 63922380
Impaired healing 198.93 9.79 855 421879 59618 64016380
Overdose 191.61 9.79 481 422253 159085 63916913
Product use issue 185.08 9.79 1659 421075 150056 63925942
Sinusitis 183.83 9.79 1607 421127 144321 63931677
Sickle cell anaemia with crisis 176.94 9.79 196 422538 5136 64070862
Red blood cell sedimentation rate abnormal 173.34 9.79 351 422383 15955 64060043
Abortion spontaneous 170.98 9.79 454 422280 24689 64051309
Suicide attempt 165.94 9.79 133 422601 70874 64005124
Lower respiratory tract infection 159.58 9.79 1115 421619 93499 63982499
Depressed level of consciousness 155 9.79 183 422551 81253 63994745
Peripheral swelling 154.53 9.79 2070 420664 207083 63868915
Muscle injury 153.79 9.79 451 422283 25986 64050012
Arthritis 152.25 9.79 1006 421728 82808 63993190
Blood pressure fluctuation 151.51 9.79 708 422026 51163 64024835
Respiratory arrest 148.45 9.79 81 422653 52904 64023094
Hypersensitivity 145.40 9.79 1945 420789 194507 63881491
Psoriasis 145.32 9.79 885 421849 70818 64005180
Folliculitis 142.61 9.79 478 422256 29599 64046399
Pregnancy 142.13 9.79 377 422357 20488 64055510
Knee arthroplasty 139.65 9.79 442 422292 26557 64049441
Disease progression 138.80 9.79 470 422264 141210 63934788
Treatment failure 138.65 9.79 1270 421464 115546 63960452
Hip arthroplasty 137.62 9.79 378 422356 20973 64055025
Bradycardia 136.03 9.79 364 422370 117855 63958143
Sleep disorder due to general medical condition, insomnia type 134.90 9.79 429 422305 25841 64050157
Rhabdomyolysis 129.35 9.79 253 422481 91473 63984525
Sedation 128.94 9.79 55 422679 41407 64034591
Malignant neoplasm progression 128.76 9.79 349 422385 112522 63963476
Irritable bowel syndrome 128.03 9.79 535 422199 36834 64039164
Acute kidney injury 126.51 9.79 2127 420607 447113 63628885
Osteoarthritis 124.11 9.79 775 421959 62561 64013437
Pancytopenia 122.70 9.79 1458 421276 141851 63934147
Weight increased 116.67 9.79 2006 420728 211342 63864656
Constipation 111.69 9.79 963 421771 228374 63847624
Drug reaction with eosinophilia and systemic symptoms 110.68 9.79 115 422619 54102 64021896
Blister 109.99 9.79 907 421827 80060 63995938
Drug resistance 108.46 9.79 47 422687 35055 64040943
Renal failure 108.31 9.79 721 422013 180967 63895031
Agitation 105.54 9.79 267 422467 88100 63987898
Drug dependence 103.89 9.79 44 422690 33268 64042730
Red blood cell sedimentation rate increased 101.45 9.79 440 422294 30795 64045203
Serotonin syndrome 98.97 9.79 68 422666 39214 64036784
Injection site erythema 98.80 9.79 798 421936 70002 64005996
Cardio-respiratory arrest 97.30 9.79 325 422409 98068 63977930
Enthesopathy 97.17 9.79 203 422531 9435 64066563
Hepatic failure 94.57 9.79 135 422599 55259 64020739
Ill-defined disorder 94.55 9.79 552 422182 43500 64032498
Infection 94.51 9.79 1720 421014 183160 63892838
Live birth 93.76 9.79 219 422515 10985 64065013
Drug ineffective 93.65 9.79 6546 416188 833701 63242297
Hepatic function abnormal 91.87 9.79 176 422558 64137 64011861
Respiratory failure 91.42 9.79 649 422085 160534 63915464
Caesarean section 90.69 9.79 217 422517 11057 64064941
Intentional product misuse 90.61 9.79 213 422521 72082 64003916
Joint effusion 89.30 9.79 241 422493 13232 64062766
Juvenile idiopathic arthritis 88.57 9.79 118 422616 3761 64072237
Hypotension 88.50 9.79 1864 420870 379110 63696888
Condition aggravated 87.54 9.79 3121 419613 369305 63706693
Injection site pruritus 87.11 9.79 483 422251 37343 64038655
Contusion 85.75 9.79 1132 421602 112833 63963165
C-reactive protein increased 84.04 9.79 972 421762 93937 63982061
Cardiac failure 83.62 9.79 516 422218 131857 63944141
Electrocardiogram QT prolonged 83.03 9.79 256 422478 79192 63996806
Blood pressure systolic increased 82.88 9.79 582 422152 48871 64027127
Osteoporosis 80.62 9.79 512 422222 41568 64034430
Intentional self-injury 80.48 9.79 45 422689 28999 64046999
Blood pressure diastolic abnormal 79.82 9.79 214 422520 11703 64064295
Rheumatoid nodule 79.58 9.79 222 422512 12429 64063569
Hypoglycaemia 79.56 9.79 311 422423 89581 63986417
Poisoning 78.32 9.79 23 422711 21856 64054142
Palmar-plantar erythrodysaesthesia syndrome 77.93 9.79 46 422688 28773 64047225
Disability assessment scale score increased 77.14 9.79 89 422645 2441 64073557
Basal cell carcinoma 76.58 9.79 402 422332 30436 64045562
Hyperglycaemia 76.10 9.79 180 422554 60788 64015210
Lactic acidosis 76.10 9.79 182 422552 61228 64014770
Hypoxia 76.09 9.79 308 422426 87841 63988157
Device expulsion 76.06 9.79 22 422712 21114 64054884
Blood pressure systolic abnormal 75.32 9.79 187 422547 9755 64066243
Somnolence 75.23 9.79 913 421821 202732 63873266
Multiple organ dysfunction syndrome 75.14 9.79 375 422359 101038 63974960
Drug withdrawal syndrome 75.13 9.79 57 422677 31234 64044764
Coma 74.46 9.79 308 422426 87307 63988691
Rheumatic fever 73.80 9.79 178 422556 9116 64066882
Tenosynovitis 73.79 9.79 207 422527 11626 64064372
Musculoskeletal pain 72.61 9.79 834 421900 80460 63995538
Premature delivery 72.38 9.79 277 422457 18312 64057686
Cardiac failure congestive 71.51 9.79 531 422203 130049 63945949
Respiratory depression 71.46 9.79 32 422702 23411 64052587
Cytomegalovirus infection 71.40 9.79 83 422651 37116 64038882
Neuropathy peripheral 70.19 9.79 466 422268 117059 63958939
Injection site pain 69.19 9.79 1070 421664 110338 63965660
Injection site swelling 68.90 9.79 486 422248 40867 64035131
Neutropenia 68.77 9.79 1130 421604 238494 63837504
Sopor 68.73 9.79 56 422678 29605 64046393
Swollen joint count increased 68.44 9.79 154 422580 7535 64068463
Grip strength decreased 68.18 9.79 200 422534 11524 64064474
Injection site reaction 67.85 9.79 531 422203 46133 64029865
Foot deformity 67.63 9.79 250 422484 16254 64059744
Product use in unapproved indication 67.46 9.79 786 421948 175832 63900166
Joint laxity 66.55 9.79 79 422655 2235 64073763
Renal impairment 65.65 9.79 567 422167 134450 63941548
Inflammation 65.24 9.79 685 422049 64615 64011383
Neoplasm progression 64.00 9.79 106 422628 40858 64035140
Blood creatine phosphokinase increased 63.84 9.79 185 422549 58373 64017625
Polyarthritis 63.61 9.79 173 422561 9542 64066456
Blood pressure diastolic decreased 63.35 9.79 302 422432 21999 64053999
Fibromyalgia 63.12 9.79 426 422308 35305 64040693
Tachycardia 62.96 9.79 651 422083 148928 63927070
Hyperhidrosis 62.80 9.79 520 422214 124400 63951598
Pre-eclampsia 60.22 9.79 129 422605 6102 64069896
Joint stiffness 59.52 9.79 372 422362 30032 64045966
Neuroleptic malignant syndrome 59.42 9.79 46 422688 24950 64051048
Pain in extremity 59.32 9.79 2490 420244 300595 63775403
Rash 58.84 9.79 3617 419117 454932 63621066
Fracture 57.72 9.79 260 422474 18495 64057503
Shock 56.06 9.79 103 422631 38137 64037861
Acute hepatic failure 56.03 9.79 53 422681 26059 64049939
Localised infection 55.94 9.79 364 422370 29797 64046201
Tremor 55.31 9.79 663 422071 147567 63928431
Myalgia 55.24 9.79 720 422014 157897 63918101
Femur fracture 55.02 9.79 398 422336 33737 64042261
Diabetic ketoacidosis 54.73 9.79 69 422665 29776 64046222
Heart rate decreased 54.23 9.79 576 422158 54491 64021507
Fatigue 54.23 9.79 5650 417084 743080 63332918
Premature rupture of membranes 54.13 9.79 92 422642 3652 64072346
Mental status changes 53.86 9.79 212 422522 60950 64015048
Bone erosion 53.83 9.79 183 422551 11412 64064586
Herpes zoster 53.62 9.79 772 421962 78415 63997583
Maternal exposure before pregnancy 53.58 9.79 88 422646 3395 64072603
Myocardial infarction 52.97 9.79 766 421968 165055 63910943
Syncope 52.91 9.79 721 422013 156914 63919084
Anxiety 52.55 9.79 973 421761 201676 63874322
Premature labour 52.21 9.79 138 422596 7482 64068516
Hyponatraemia 52.15 9.79 672 422062 147667 63928331
Stomatitis 51.92 9.79 1008 421726 108597 63967401
Angioedema 51.48 9.79 219 422515 61602 64014396
Infective pulmonary exacerbation of cystic fibrosis 51.17 9.79 8 422726 11788 64064210
Unresponsive to stimuli 50.81 9.79 165 422569 50228 64025770
Immune reconstitution inflammatory syndrome 50.73 9.79 10 422724 12460 64063538
Altered state of consciousness 50.48 9.79 108 422626 37794 64038204
Gastrointestinal disorder 50.23 9.79 847 421887 88862 63987136
Sedation complication 49.83 9.79 5 422729 10349 64065649
Mydriasis 49.74 9.79 19 422715 15293 64060705
Loss of personal independence in daily activities 49.71 9.79 708 422026 71746 64004252
Neurotoxicity 49.58 9.79 64 422670 27340 64048658
Disseminated intravascular coagulation 49.34 9.79 85 422649 32263 64043735
Hallucination 48.98 9.79 278 422456 72510 64003488
Tuberculosis 48.90 9.79 192 422542 12846 64063152
Tongue disorder 48.68 9.79 182 422552 11898 64064100
Dizziness 48.57 9.79 2314 420420 427849 63648149
Latent tuberculosis 48.40 9.79 74 422660 2683 64073315
Nausea 48.03 9.79 4467 418267 781333 63294665
Skin ulcer 47.61 9.79 469 422265 43505 64032493
Injection site bruising 47.53 9.79 404 422330 35969 64040029
Abnormal behaviour 47.15 9.79 93 422641 33529 64042469
Blood glucose increased 47.15 9.79 413 422321 97660 63978338
Pulmonary fibrosis 46.80 9.79 346 422388 29532 64046466
Synovial cyst 46.28 9.79 133 422601 7574 64068424
Blood pressure increased 45.75 9.79 1467 421267 171085 63904913
Joint destruction 45.66 9.79 84 422650 3552 64072446
Urticaria 45.49 9.79 685 422049 146632 63929366
Nodule 45.28 9.79 235 422499 17712 64058286
Drug hypersensitivity 45.27 9.79 1199 421535 236616 63839382
Oropharyngeal pain 45.09 9.79 826 421908 88041 63987957
Blood pressure diastolic increased 45.01 9.79 164 422570 10588 64065410
Post transplant lymphoproliferative disorder 44.92 9.79 5 422729 9539 64066459
Neutrophil count decreased 44.63 9.79 309 422425 76887 63999111
Foetal death 44.36 9.79 111 422623 5819 64070179
Brain oedema 43.73 9.79 48 422686 22027 64053971
Vomiting 43.56 9.79 3068 419666 548049 63527949
Substance abuse 43.41 9.79 5 422729 9287 64066711
Multiple sclerosis relapse 43.36 9.79 132 422602 41003 64034995
Fluid retention 43.23 9.79 222 422512 59384 64016614
Ventricular fibrillation 42.89 9.79 56 422678 23804 64052194
Tendonitis 42.77 9.79 253 422481 20029 64055969
Speech disorder 42.59 9.79 168 422566 48273 64027725
Ventricular tachycardia 42.09 9.79 102 422632 34163 64041835
Bronchitis 42.07 9.79 971 421763 107772 63968226
Dyspnoea 41.95 9.79 4099 418635 714575 63361423
Pathogen resistance 41.70 9.79 15 422719 12528 64063470
Body temperature decreased 41.61 9.79 302 422432 25626 64050372
Delirium 41.48 9.79 274 422460 68920 64007078
Foetal exposure during pregnancy 41.36 9.79 91 422643 4385 64071613
Joint range of motion decreased 41.25 9.79 242 422492 19101 64056897
Cognitive disorder 41.19 9.79 203 422531 54884 64021114
Injection site rash 41.02 9.79 208 422526 15534 64060464
Neck deformity 40.51 9.79 53 422681 1659 64074339
Seizure 40.30 9.79 811 421923 166081 63909917
Product quality issue 39.61 9.79 85 422649 29714 64046284
Irritability 39.39 9.79 117 422617 36629 64039369
Encephalopathy 38.85 9.79 226 422508 58593 64017405
Orthostatic hypotension 38.04 9.79 167 422567 46571 64029427
Drug ineffective for unapproved indication 37.99 9.79 93 422641 31040 64044958
Malignant melanoma 37.87 9.79 177 422557 12787 64063211
Limb deformity 37.70 9.79 74 422660 3287 64072711
Torsade de pointes 37.54 9.79 35 422699 17328 64058670
Red blood cell sedimentation rate 37.18 9.79 78 422656 3636 64072362
Suicidal ideation 37.17 9.79 269 422465 66273 64009725
Laryngitis 37.05 9.79 157 422577 10874 64065124
Disability 36.90 9.79 168 422566 12004 64063994
Alanine aminotransferase abnormal 36.75 9.79 114 422620 6774 64069224
Balance disorder 36.65 9.79 362 422372 83564 63992434
Aspergillus infection 36.63 9.79 32 422702 16347 64059651
Tenderness 36.61 9.79 237 422497 19365 64056633
Diarrhoea 36.24 9.79 4166 418568 718538 63357460
Oral herpes 36.11 9.79 259 422475 21893 64054105
Mouth ulceration 36.09 9.79 348 422386 32096 64043902
Multiple fractures 36.04 9.79 104 422630 5936 64070062
Neck mass 36.00 9.79 81 422653 3963 64072035
Arthritis infective 35.36 9.79 114 422620 6916 64069082
Hypothermia 35.28 9.79 47 422687 19809 64056189
Venoocclusive liver disease 34.99 9.79 11 422723 10004 64065994
Metabolic acidosis 34.91 9.79 297 422437 70661 64005337
Pulmonary arterial hypertension 34.86 9.79 71 422663 25296 64050702
Akathisia 34.63 9.79 16 422718 11494 64064504
Skin papilloma 34.41 9.79 93 422641 5110 64070888
Joint injury 34.40 9.79 263 422471 22684 64053314
Psychotic disorder 34.31 9.79 114 422620 34464 64041534
Transplant rejection 34.29 9.79 38 422696 17363 64058635
Emotional distress 34.28 9.79 121 422613 35917 64040081
General physical health deterioration 33.95 9.79 1652 421082 202773 63873225
Smear cervix abnormal 33.88 9.79 58 422676 2316 64073682
Respiratory distress 33.54 9.79 203 422531 52128 64023870
Muscle spasms 33.53 9.79 687 422047 140336 63935662
Cardiogenic shock 33.51 9.79 105 422629 32322 64043676
Ear infection 33.29 9.79 265 422469 23139 64052859
Skin cancer 33.18 9.79 161 422573 11813 64064185
Drug level increased 33.08 9.79 114 422620 34082 64041916
Haematotoxicity 32.92 9.79 22 422712 12874 64063124
Normal newborn 32.83 9.79 96 422638 5521 64070477
Asphyxia 32.56 9.79 11 422723 9555 64066443
Pulmonary tuberculosis 32.47 9.79 113 422621 7131 64068867
Poor venous access 32.31 9.79 164 422570 12253 64063745
Spinal stenosis 32.14 9.79 178 422556 13753 64062245
Extrapyramidal disorder 32.05 9.79 49 422685 19503 64056495
No adverse event 32.03 9.79 89 422645 28472 64047526
Decreased appetite 31.92 9.79 1512 421222 279777 63796221
Mucormycosis 31.80 9.79 5 422729 7336 64068662
Asthma 31.77 9.79 436 422298 94789 63981209
Asthenia 31.65 9.79 2396 420338 425648 63650350
Anaphylactic shock 31.48 9.79 98 422636 30230 64045768
Vision blurred 31.41 9.79 410 422324 89906 63986092
Immunodeficiency 31.38 9.79 197 422537 15927 64060071
Forced expiratory volume decreased 31.33 9.79 4 422730 6863 64069135
Restlessness 31.27 9.79 144 422590 39641 64036357
Coronary artery disease 31.07 9.79 250 422484 60183 64015815
Cerebrovascular accident 31.02 9.79 676 422058 136907 63939091
Disturbance in attention 30.91 9.79 151 422583 40923 64035075
Graft versus host disease 30.87 9.79 27 422707 13786 64062212
White blood cell count decreased 30.75 9.79 793 421941 157044 63918954
Blood creatinine increased 30.66 9.79 667 422067 135115 63940883
Disorientation 30.55 9.79 227 422507 55601 64020397
Unintentional medical device removal 30.53 9.79 4 422730 6730 64069268
Depression 30.33 9.79 942 421792 182349 63893649
Second primary malignancy 30.23 9.79 22 422712 12315 64063683
BK virus infection 30.03 9.79 6 422728 7406 64068592
Small for dates baby 29.79 9.79 24 422710 415 64075583
Cytokine release syndrome 29.74 9.79 57 422677 20772 64055226
Tumour lysis syndrome 29.72 9.79 51 422683 19389 64056609
Withdrawal syndrome 29.60 9.79 69 422665 23423 64052575
Tenosynovitis stenosans 29.45 9.79 49 422685 1911 64074087
Wheelchair user 29.40 9.79 82 422652 4590 64071408
Dystonia 29.30 9.79 49 422685 18816 64057182
Proteinuria 29.19 9.79 89 422645 27634 64048364
Coagulopathy 29.15 9.79 109 422625 31811 64044187
Bone disorder 29.11 9.79 199 422535 16560 64059438
Polyhydramnios 29.10 9.79 42 422692 1445 64074553
Fear 28.98 9.79 55 422679 20116 64055882
Creatinine renal clearance decreased 28.96 9.79 31 422703 14390 64061608
Ascites 28.96 9.79 263 422471 61738 64014260
Fear of injection 28.95 9.79 95 422639 5817 64070181
Immunosuppression 28.71 9.79 143 422591 10603 64065395
Status epilepticus 28.62 9.79 62 422672 21601 64054397
Mania 28.48 9.79 39 422695 16247 64059751
Inappropriate antidiuretic hormone secretion 28.46 9.79 65 422669 22224 64053774
Gastrointestinal haemorrhage 28.44 9.79 655 422079 131657 63944341
Anaphylactic reaction 27.99 9.79 301 422433 68363 64007635
Haemorrhage intracranial 27.86 9.79 73 422661 23811 64052187
Pulmonary oedema 27.78 9.79 356 422378 78318 63997680
Posterior reversible encephalopathy syndrome 27.64 9.79 69 422665 22877 64053121
Product administration error 27.52 9.79 91 422643 27552 64048446
Cerebral infarction 27.48 9.79 157 422577 40887 64035111
Aggression 27.24 9.79 184 422550 46048 64029950
Wrong technique in product usage process 27.23 9.79 283 422451 64691 64011307
Therapeutic response decreased 27.14 9.79 487 422247 51701 64024297
Atrial fibrillation 26.93 9.79 885 421849 170204 63905794
Arrhythmia 26.77 9.79 220 422514 52724 64023274
Aphthous ulcer 26.58 9.79 160 422574 12746 64063252
Drug use disorder 26.50 9.79 4 422730 6050 64069948
Cerebral haemorrhage 26.42 9.79 211 422523 50879 64025119
Glycosylated haemoglobin increased 26.40 9.79 40 422694 15979 64060019
Ulcer 26.26 9.79 248 422486 22742 64053256
Gastroenteritis viral 26.23 9.79 220 422514 19509 64056489
Myoclonus 26.19 9.79 81 422653 25037 64050961
Stillbirth 26.13 9.79 67 422667 3566 64072432
Abortion late 26.09 9.79 12 422722 68 64075930
Foot fracture 26.05 9.79 206 422528 17951 64058047
Joint noise 26.04 9.79 62 422672 3149 64072849
Synovial fluid analysis 25.99 9.79 41 422693 1528 64074470
Influenza 25.99 9.79 897 421837 105634 63970364
Rotator cuff repair 25.99 9.79 40 422694 1459 64074539
Acute chest syndrome 25.90 9.79 31 422703 885 64075113
Muscle rigidity 25.67 9.79 47 422687 17426 64058572
Haemorrhage 25.51 9.79 366 422368 78985 63997013
Leukocytosis 25.46 9.79 144 422590 37596 64038402
Dysarthria 25.20 9.79 258 422476 59148 64016850
Fracture delayed union 25.11 9.79 46 422688 1939 64074059
Potentiating drug interaction 25.08 9.79 10 422724 7842 64068156
Dysgeusia 24.94 9.79 193 422541 46854 64029144
Chest pain 24.90 9.79 1278 421456 234702 63841296
Platelet count decreased 24.89 9.79 874 421860 166837 63909161
Tachypnoea 24.75 9.79 90 422644 26481 64049517
Abortion threatened 24.73 9.79 21 422713 392 64075606
Loose body in joint 24.72 9.79 35 422699 1183 64074815
Paradoxical drug reaction 24.70 9.79 5 422729 6115 64069883
Injection site warmth 24.67 9.79 162 422572 13300 64062698
Bursitis 24.66 9.79 232 422502 21253 64054745
Dactylitis 24.62 9.79 45 422689 1893 64074105
Insomnia 24.55 9.79 1053 421681 196783 63879215
Flushing 24.51 9.79 365 422369 78283 63997715
Post procedural infection 24.44 9.79 126 422608 9471 64066527
Antinuclear antibody positive 24.22 9.79 93 422641 6157 64069841
Toxic epidermal necrolysis 23.91 9.79 144 422590 37022 64038976
Acute graft versus host disease 23.86 9.79 15 422719 9069 64066929
Maternal exposure timing unspecified 23.85 9.79 54 422680 2653 64073345
Respiratory disorder 23.71 9.79 139 422595 35972 64040026
Surgery 23.65 9.79 286 422448 27927 64048071
Pain in jaw 23.62 9.79 163 422571 40592 64035406
Cyanosis 23.41 9.79 71 422663 22084 64053914
Haemorrhage in pregnancy 23.38 9.79 35 422699 1245 64074753
Pulmonary embolism 23.29 9.79 756 421978 145600 63930398
Loss of consciousness 23.22 9.79 768 421966 147597 63928401
Blood bilirubin increased 23.18 9.79 253 422481 57300 64018698
Foetal distress syndrome 23.09 9.79 21 422713 431 64075567
Psychomotor hyperactivity 22.94 9.79 37 422697 14414 64061584
Exposure to toxic agent 22.93 9.79 6 422728 6153 64069845
Speech disorder developmental 22.92 9.79 23 422711 536 64075462
Oligohydramnios 22.87 9.79 58 422676 3066 64072932
Device use error 22.80 9.79 7 422727 6464 64069534
Scleritis 22.69 9.79 56 422678 2910 64073088
Dehydration 22.66 9.79 1175 421559 215588 63860410
Blood parathyroid hormone decreased 22.58 9.79 102 422632 7264 64068734
Endophthalmitis 22.47 9.79 4 422730 5361 64070637
Pulmonary hypertension 22.38 9.79 178 422556 42961 64033037
Blood cholesterol increased 22.21 9.79 456 422278 49610 64026388
Pancreatitis 22.07 9.79 267 422467 59340 64016658
Breast feeding 22.06 9.79 25 422709 672 64075326
Miosis 21.98 9.79 33 422701 13233 64062765
Adenovirus infection 21.96 9.79 10 422724 7245 64068753
Respiration abnormal 21.95 9.79 7 422727 6308 64069690
Ejection fraction decreased 21.91 9.79 105 422629 28602 64047396
Bronchospasm 21.85 9.79 71 422663 21611 64054387
Acidosis 21.83 9.79 53 422681 17742 64058256
Muscle spasticity 21.78 9.79 48 422686 16621 64059377
Dysmorphism 21.74 9.79 22 422712 518 64075480
Placental insufficiency 21.73 9.79 30 422704 990 64075008
Respiratory disorder neonatal 21.70 9.79 10 422724 57 64075941
Pneumatosis intestinalis 21.68 9.79 4 422730 5225 64070773
Incorrect route of product administration 21.64 9.79 79 422655 23219 64052779
Dyskinesia 21.62 9.79 160 422574 39228 64036770
Bradyphrenia 21.49 9.79 18 422716 9388 64066610
Chest discomfort 21.38 9.79 588 422146 115518 63960480
Induced labour 21.29 9.79 27 422707 819 64075179
Chronic kidney disease 21.23 9.79 260 422474 57659 64018339
Nocardiosis 21.22 9.79 3 422731 4764 64071234
Low birth weight baby 21.13 9.79 22 422712 536 64075462
Bronchopulmonary aspergillosis 21.01 9.79 60 422674 19025 64056973
Haemoptysis 20.81 9.79 213 422521 48835 64027163
Feeling abnormal 20.81 9.79 692 422042 132910 63943088
Arthritis bacterial 20.72 9.79 104 422630 7735 64068263
Placental disorder 20.69 9.79 27 422707 843 64075155
Hypokalaemia 20.52 9.79 625 422109 121278 63954720
Tardive dyskinesia 20.44 9.79 18 422716 9160 64066838
Synovial disorder 20.37 9.79 28 422706 920 64075078
Stevens-Johnson syndrome 20.33 9.79 136 422598 34113 64041885
Rhinorrhoea 20.33 9.79 526 422208 59443 64016555
Klebsiella infection 20.16 9.79 35 422699 13246 64062752
Thrombotic microangiopathy 20.12 9.79 50 422684 16605 64059393
Lupus-like syndrome 20.06 9.79 112 422622 8679 64067319
Granuloma skin 20.05 9.79 86 422648 5988 64070010
Sinus tachycardia 20.03 9.79 126 422608 32062 64043936
Hypomagnesaemia 19.96 9.79 153 422581 37223 64038775
Thrombocytopenia 19.95 9.79 1232 421502 222569 63853429
Folate deficiency 19.92 9.79 51 422683 2712 64073286
Erythema multiforme 19.87 9.79 46 422688 15655 64060343
Metastases to bone 19.85 9.79 68 422666 20367 64055631
Cardiac failure acute 19.80 9.79 49 422685 16295 64059703
Device difficult to use 19.75 9.79 21 422713 9777 64066221
Blood alkaline phosphatase increased 19.74 9.79 255 422479 56024 64019974
Cystitis haemorrhagic 19.74 9.79 14 422720 7942 64068056
Frequent bowel movements 19.70 9.79 195 422539 18110 64057888
Nightmare 19.62 9.79 71 422663 20922 64055076
Panniculitis 19.53 9.79 112 422622 8767 64067231
Dermatitis acneiform 19.49 9.79 16 422718 8427 64067571
Anal fistula 19.41 9.79 77 422657 5176 64070822
Postoperative wound infection 19.32 9.79 125 422609 10211 64065787
Blood pressure decreased 19.29 9.79 424 422310 85775 63990223
Anuria 19.18 9.79 62 422672 18902 64057096
Bronchial carcinoma 19.12 9.79 30 422704 1113 64074885
Oxygen saturation decreased 19.02 9.79 872 421862 106304 63969694
Intentional product use issue 18.95 9.79 785 421949 94579 63981419
Subdural haematoma 18.95 9.79 107 422627 27947 64048051
Pleural effusion 18.90 9.79 659 422075 125900 63950098
Delusion 18.84 9.79 58 422676 17956 64058042
Pharyngitis streptococcal 18.84 9.79 109 422625 8559 64067439
Cushingoid 18.80 9.79 99 422635 7504 64068494
Acute respiratory failure 18.74 9.79 223 422511 49711 64026287
Colitis ulcerative 18.68 9.79 232 422502 22796 64053202
Joint dislocation 18.66 9.79 134 422600 11331 64064667
Hospitalisation 18.58 9.79 364 422370 74843 64001155
Abortion missed 18.55 9.79 30 422704 1142 64074856
Anger 18.44 9.79 48 422686 15693 64060305
Foetal anticonvulsant syndrome 18.39 9.79 14 422720 222 64075776
Mobility decreased 18.31 9.79 712 422022 85128 63990870
Tooth abscess 18.29 9.79 154 422580 13672 64062326
Fine motor skill dysfunction 18.27 9.79 70 422664 4629 64071369
Palpitations 18.26 9.79 533 422201 103955 63972043
Accidental overdose 18.10 9.79 137 422597 33420 64042578
Compartment syndrome 18.07 9.79 3 422731 4229 64071769
Aphasia 18.04 9.79 176 422558 40730 64035268
Sepsis 18.00 9.79 1283 421451 229058 63846940
Sexual dysfunction 17.97 9.79 10 422724 6461 64069537
Endodontic procedure 17.92 9.79 44 422690 2279 64073719
Pulmonary congestion 17.85 9.79 88 422646 23792 64052206
International normalised ratio increased 17.83 9.79 389 422345 78778 63997220
Polyuria 17.70 9.79 35 422699 12608 64063390
Diabetes insipidus 17.62 9.79 4 422730 4517 64071481
Hypervolaemia 17.62 9.79 163 422571 38122 64037876
Hyperlactacidaemia 17.51 9.79 5 422729 4839 64071159
Haemoglobin decreased 17.44 9.79 1495 421239 193568 63882430
Tonsillitis 17.40 9.79 80 422654 5740 64070258
Renal injury 17.36 9.79 48 422686 15381 64060617
Dry eye 17.35 9.79 277 422457 28742 64047256
Electrocardiogram QRS complex prolonged 17.34 9.79 21 422713 9223 64066775
Dyspnoea exertional 17.27 9.79 360 422374 73370 64002628
Haematocrit decreased 17.27 9.79 475 422259 54180 64021818
Clostridium difficile colitis 17.23 9.79 106 422628 27117 64048881
Aspartate aminotransferase increased 17.14 9.79 627 422107 119161 63956837
B-cell lymphoma 17.05 9.79 76 422658 5381 64070617
Hyperammonaemia 17.04 9.79 24 422710 9880 64066118
Coronary arterial stent insertion 16.99 9.79 8 422726 5684 64070314
Cytomegalovirus viraemia 16.93 9.79 28 422706 10800 64065198
Pulmonary haemorrhage 16.92 9.79 38 422696 13071 64062927
Human antichimeric antibody positive 16.89 9.79 32 422702 1384 64074614
Bone pain 16.89 9.79 215 422519 47357 64028641
Lip swelling 16.86 9.79 131 422603 31776 64044222
Lethargy 16.84 9.79 355 422379 72239 64003759
Febrile bone marrow aplasia 16.78 9.79 30 422704 11225 64064773
Right ventricular failure 16.70 9.79 78 422656 21393 64054605
Twin pregnancy 16.69 9.79 24 422710 823 64075175
Ingrown hair 16.68 9.79 20 422714 572 64075426
Oesophageal fibrosis 16.66 9.79 12 422722 174 64075824
Oliguria 16.66 9.79 45 422689 14531 64061467
Gastric haemorrhage 16.66 9.79 40 422694 13441 64062557
Cellulitis 16.62 9.79 762 421972 92895 63983103
Off label use 16.57 9.79 3784 418950 629022 63446976
Exostosis 16.53 9.79 130 422604 11308 64064690
Coordination abnormal 16.51 9.79 47 422687 14917 64061081
Cholestasis of pregnancy 16.48 9.79 25 422709 900 64075098
Pemphigoid 16.47 9.79 38 422696 12948 64063050
Maternal exposure during breast feeding 16.43 9.79 39 422695 1977 64074021
Hyperkalaemia 16.41 9.79 521 422213 100608 63975390
Pulseless electrical activity 16.38 9.79 37 422697 12702 64063296
Pulmonary alveolar haemorrhage 16.35 9.79 24 422710 9714 64066284
Bronchioloalveolar carcinoma 16.25 9.79 8 422726 54 64075944
Lacrimal disorder 16.21 9.79 18 422716 473 64075525
Atrioventricular block 16.19 9.79 34 422700 11981 64064017
Serum ferritin increased 16.19 9.79 103 422631 8365 64067633
Unevaluable event 16.18 9.79 233 422501 50256 64025742
Drug abuser 16.09 9.79 9 422725 5799 64070199
Lipase increased 16.06 9.79 45 422689 14357 64061641
Spinal disorder 16.01 9.79 105 422629 8617 64067381
Obstructive airways disorder 15.89 9.79 88 422646 23097 64052901
Jaundice 15.86 9.79 223 422511 48289 64027709
Alcohol abuse 15.80 9.79 6 422728 4846 64071152
Lower respiratory tract congestion 15.79 9.79 49 422685 2912 64073086
Drug screen positive 15.69 9.79 9 422725 5720 64070278
Cardiotoxicity 15.67 9.79 27 422707 10247 64065751
Tuberculin test positive 15.65 9.79 50 422684 3018 64072980
Injection site urticaria 15.57 9.79 126 422608 11055 64064943
Hepatic encephalopathy 15.53 9.79 78 422656 20988 64055010
Memory impairment 15.50 9.79 435 422299 85247 63990751
Cholestasis 15.49 9.79 204 422530 44668 64031330
Muscle twitching 15.39 9.79 68 422666 18930 64057068
Gestational hypertension 15.33 9.79 34 422700 1647 64074351
Angina pectoris 15.18 9.79 206 422528 44875 64031123
Melaena 15.17 9.79 253 422481 53295 64022703
Anhedonia 15.15 9.79 43 422691 13663 64062335
Breast cancer 15.15 9.79 272 422462 28876 64047122
Red blood cell count decreased 15.14 9.79 420 422314 47966 64028032
Mass 15.13 9.79 160 422574 15116 64060882
Pseudomonas infection 15.10 9.79 63 422671 17820 64058178
Rheumatoid lung 15.10 9.79 43 422691 2436 64073562
Sinus bradycardia 15.09 9.79 88 422646 22805 64053193
Disease recurrence 15 9.79 133 422601 31377 64044621
Acute respiratory distress syndrome 14.95 9.79 173 422561 38762 64037236
Muscular weakness 14.92 9.79 682 422052 126656 63949342
Sickle cell anaemia 14.81 9.79 19 422715 583 64075415
Hypospadias 14.80 9.79 10 422724 130 64075868
Polydipsia 14.76 9.79 10 422724 5811 64070187
Motor developmental delay 14.73 9.79 12 422722 211 64075787
Metastases to lung 14.68 9.79 51 422683 15213 64060785
Foetal growth restriction 14.68 9.79 34 422700 1696 64074302
Cytopenia 14.68 9.79 52 422682 15419 64060579
Pneumothorax 14.67 9.79 96 422638 24202 64051796
Paralysis 14.65 9.79 34 422700 11561 64064437
Body height below normal 14.63 9.79 35 422699 1783 64074215
Weight decreased 14.62 9.79 2111 420623 283628 63792370
Nephropathy toxic 14.60 9.79 62 422672 17452 64058546
Rebound effect 14.54 9.79 7 422727 4910 64071088
Cytomegalovirus chorioretinitis 14.51 9.79 7 422727 4905 64071093
Lung neoplasm malignant 14.47 9.79 209 422525 21239 64054759
Clear cell renal cell carcinoma 14.46 9.79 39 422695 2140 64073858
Lymphocyte count decreased 14.42 9.79 184 422550 40515 64035483
Erectile dysfunction 14.42 9.79 39 422695 12588 64063410
Stress cardiomyopathy 14.42 9.79 24 422710 9233 64066765
Wound infection 14.40 9.79 155 422579 14709 64061289
Hepatitis B reactivation 14.40 9.79 7 422727 4882 64071116
Diverticular perforation 14.38 9.79 70 422664 5143 64070855
Dyslipidaemia 14.36 9.79 24 422710 9218 64066780
Joint lock 14.32 9.79 46 422688 2785 64073213
Intestinal stenosis 14.29 9.79 50 422684 3164 64072834
Bradypnoea 14.28 9.79 8 422726 5151 64070847
Bone density abnormal 14.25 9.79 45 422689 2700 64073298
Lymphatic fistula 14.24 9.79 21 422713 737 64075261
Dislocation of vertebra 14.23 9.79 49 422685 3075 64072923
Toothache 14.21 9.79 176 422558 17283 64058715
Femoral hernia incarcerated 14.18 9.79 21 422713 740 64075258
C-reactive protein decreased 14.17 9.79 38 422696 2078 64073920
Spinal osteoarthritis 14.11 9.79 150 422584 14191 64061807
Hallucination, auditory 14.10 9.79 60 422674 16879 64059119
Amniotic fluid volume increased 14.06 9.79 10 422724 142 64075856
Temperature regulation disorder 14.06 9.79 5 422729 4206 64071792
Postpartum haemorrhage 14.03 9.79 30 422704 1417 64074581
Tooth infection 14.03 9.79 152 422582 14449 64061549
Wound infection pseudomonas 13.98 9.79 31 422703 1502 64074496
Cervical incompetence 13.94 9.79 17 422717 495 64075503
Peritoneal dialysis complication 13.92 9.79 39 422695 2189 64073809
Hypercapnia 13.89 9.79 18 422716 7676 64068322
Peripheral sensory neuropathy 13.87 9.79 34 422700 11344 64064654
Failed induction of labour 13.87 9.79 12 422722 230 64075768
Cyst 13.87 9.79 130 422604 11897 64064101
End stage renal disease 13.82 9.79 30 422704 10445 64065553
Graft versus host disease in skin 13.81 9.79 9 422725 5338 64070660
Metastases to liver 13.75 9.79 96 422638 23845 64052153
Progressive multifocal leukoencephalopathy 13.73 9.79 67 422667 18165 64057833
Abortion induced 13.67 9.79 80 422654 6308 64069690
Arthropod bite 13.63 9.79 83 422651 6638 64069360
Hypophosphataemia 13.62 9.79 50 422684 14670 64061328
Chondropathy 13.59 9.79 40 422694 2309 64073689
Adverse event 13.57 9.79 347 422387 39142 64036856
Pancreatic steatosis 13.57 9.79 24 422710 984 64075014
Paranoia 13.56 9.79 58 422676 16294 64059704
Complication of device insertion 13.55 9.79 8 422726 5004 64070994
Anaemia folate deficiency 13.53 9.79 12 422722 238 64075760
Iodine allergy 13.52 9.79 17 422717 511 64075487
Bacteraemia 13.52 9.79 112 422622 26799 64049199
Lung transplant 13.51 9.79 5 422729 4103 64071895
Sciatica 13.49 9.79 197 422537 20067 64055931
Hepatic cyst 13.49 9.79 69 422665 5171 64070827
Uterine perforation 13.47 9.79 11 422723 5809 64070189
Invasive ductal breast carcinoma 13.40 9.79 67 422667 4975 64071023
Delivery 13.39 9.79 17 422717 516 64075482
Malignant mediastinal neoplasm 13.37 9.79 17 422717 517 64075481
Joint warmth 13.32 9.79 29 422705 1387 64074611
Myopathy 13.30 9.79 65 422669 17615 64058383
Hyperprolactinaemia 13.28 9.79 5 422729 4060 64071938
Anaemia 13.21 9.79 2231 420503 376449 63699549
Hyperbilirubinaemia 13.20 9.79 83 422651 21122 64054876
Capillary fragility 13.19 9.79 11 422723 200 64075798
Respiratory acidosis 13.19 9.79 28 422706 9827 64066171
Accidental death 13.18 9.79 4 422730 3721 64072277
Alanine aminotransferase increased 13.15 9.79 761 421973 138270 63937728
Musculoskeletal disorder 13.10 9.79 177 422557 17729 64058269
Breast abscess 13.09 9.79 25 422709 1088 64074910
Panic attack 13.05 9.79 82 422652 20871 64055127
Metastases to central nervous system 13.04 9.79 47 422687 13865 64062133
Blood folate increased 13.04 9.79 16 422718 469 64075529
Lymphoproliferative disorder 13.00 9.79 67 422667 5036 64070962
Antibody test positive 12.99 9.79 40 422694 2367 64073631
Hepatotoxicity 12.96 9.79 184 422550 39778 64036220
Mycobacterium tuberculosis complex test positive 12.95 9.79 36 422698 2011 64073987
Acute coronary syndrome 12.85 9.79 74 422660 19236 64056762
Transplant dysfunction 12.84 9.79 15 422719 6693 64069305
Pleuritic pain 12.82 9.79 94 422640 8002 64067996
Anaemia macrocytic 12.81 9.79 60 422674 4338 64071660
Eyelid ptosis 12.80 9.79 27 422707 9498 64066500
Pyelonephritis acute 12.79 9.79 67 422667 5067 64070931
Colitis microscopic 12.79 9.79 18 422716 7414 64068584
Ankle arthroplasty 12.75 9.79 22 422712 884 64075114
Blood lactic acid increased 12.74 9.79 31 422703 10370 64065628
Ventricular arrhythmia 12.72 9.79 18 422716 7397 64068601
Tendon disorder 12.72 9.79 78 422656 6254 64069744
Osteonecrosis of jaw 12.69 9.79 184 422550 39641 64036357
Atrioventricular block complete 12.67 9.79 50 422684 14368 64061630
Gastroenteritis 12.65 9.79 269 422465 29442 64046556
Purging 12.63 9.79 6 422728 37 64075961
Plasma cell myeloma 12.63 9.79 219 422515 45856 64030142
Threatened labour 12.61 9.79 17 422717 548 64075450
Drug-induced liver injury 12.56 9.79 228 422506 47415 64028583
Abdominal distension 12.51 9.79 508 422226 95486 63980512
Palindromic rheumatism 12.48 9.79 13 422721 317 64075681
Human anti-human antibody test 12.42 9.79 14 422720 374 64075624
Acute graft versus host disease in skin 12.41 9.79 16 422718 6839 64069159
Cystitis 12.40 9.79 367 422367 42308 64033690
Oedema 12.31 9.79 485 422249 91450 63984548
Accessory spleen 12.31 9.79 10 422724 175 64075823
Heparin-induced thrombocytopenia 12.28 9.79 23 422711 8456 64067542
Prothrombin consumption time prolonged 12.25 9.79 6 422728 40 64075958
Persecutory delusion 12.17 9.79 6 422728 4152 64071846
Medical device site joint infection 12.17 9.79 11 422723 224 64075774
Renal disorder 12.12 9.79 161 422573 35204 64040794
Mesothelioma 12.09 9.79 13 422721 329 64075669
Genital haemorrhage 12.09 9.79 11 422723 5511 64070487
Type 2 diabetes mellitus 12 9.79 300 422434 33720 64042278
Tubulointerstitial nephritis 12.00 9.79 137 422597 30772 64045226
Mean cell volume increased 11.99 9.79 65 422669 4981 64071017
Mental disorder 11.99 9.79 113 422621 26332 64049666
Axonal neuropathy 11.96 9.79 31 422703 1661 64074337
Alcohol interaction 11.93 9.79 7 422727 4394 64071604
Labelled drug-drug interaction medication error 11.93 9.79 90 422644 21972 64054026
Toxoplasma serology positive 11.89 9.79 6 422728 43 64075955
Finger deformity 11.79 9.79 66 422668 5120 64070878
Amylase increased 11.76 9.79 29 422705 9656 64066342
Acute myeloid leukaemia 11.76 9.79 119 422615 27344 64048654
Myofascial pain syndrome 11.75 9.79 32 422702 1766 64074232
Anal prolapse 11.75 9.79 7 422727 72 64075926
Blood glucose decreased 11.72 9.79 96 422638 23027 64052971
Knee operation 11.72 9.79 60 422674 4497 64071501
Haemodynamic instability 11.70 9.79 54 422680 14858 64061140
Skin laceration 11.70 9.79 225 422509 24192 64051806
Schizophrenia 11.65 9.79 36 422698 11132 64064866
Taste disorder 11.65 9.79 28 422706 9405 64066593
Cardiomyopathy 11.65 9.79 108 422626 25248 64050750
Tooth disorder 11.63 9.79 209 422525 22193 64053805
Heart rate irregular 11.61 9.79 248 422486 27165 64048833
Adjustment disorder with depressed mood 11.60 9.79 39 422695 2418 64073580
Pelvic fracture 11.60 9.79 113 422621 10450 64065548
Injection site discolouration 11.57 9.79 81 422653 6794 64069204
Ataxia 11.51 9.79 91 422643 21993 64054005
Drug specific antibody 11.48 9.79 35 422699 2060 64073938
Pharyngitis 11.48 9.79 182 422552 18857 64057141
Skin exfoliation 11.46 9.79 216 422518 44669 64031329
Oxygen consumption increased 11.45 9.79 8 422726 4573 64071425
Accidental exposure to product 11.39 9.79 114 422620 26250 64049748
Hyperlipidaemia 11.37 9.79 96 422638 22880 64053118
Stress at work 11.37 9.79 22 422712 967 64075031
Dysphagia 11.34 9.79 578 422156 106234 63969764
Skin ulcer haemorrhage 11.24 9.79 15 422719 479 64075519
Hyperhomocysteinaemia 11.23 9.79 14 422720 417 64075581
Injection site extravasation 11.20 9.79 91 422643 7995 64068003
Congenital umbilical hernia 11.19 9.79 4 422730 10 64075988
Catheter management 11.17 9.79 4 422730 3351 64072647
Myelosuppression 11.16 9.79 101 422633 23729 64052269
Osteoporotic fracture 11.16 9.79 50 422684 3548 64072450
Hepatitis C 11.15 9.79 36 422698 10979 64065019
Foot operation 11.06 9.79 56 422678 4179 64071819
Complication of pregnancy 11.06 9.79 12 422722 307 64075691
Cardiac failure chronic 11.03 9.79 27 422707 9014 64066984
Deep vein thrombosis 11.01 9.79 570 422164 104612 63971386
Hiatus hernia 11.01 9.79 188 422546 19769 64056229
Hepatitis fulminant 11.00 9.79 15 422719 6259 64069739
Angina unstable 10.99 9.79 58 422676 15409 64060589
Myocarditis 10.98 9.79 66 422668 16977 64059021
Gastrooesophageal sphincter insufficiency 10.97 9.79 10 422724 206 64075792
Multiple-drug resistance 10.94 9.79 16 422718 6486 64069512
Large intestinal stenosis 10.91 9.79 38 422696 2399 64073599
Ileus 10.90 9.79 97 422637 22869 64053129
Hyperthyroidism 10.88 9.79 72 422662 18107 64057891
Hypertelorism 10.88 9.79 8 422726 120 64075878
Hypertransaminasaemia 10.87 9.79 19 422715 7172 64068826
Vanishing twin syndrome 10.84 9.79 7 422727 84 64075914
Blood calcium decreased 10.83 9.79 111 422623 25443 64050555
Corneal degeneration 10.82 9.79 8 422726 121 64075877
Lordosis 10.76 9.79 12 422722 317 64075681
Vitamin B12 deficiency 10.74 9.79 67 422667 5405 64070593
Hypoxic-ischaemic encephalopathy 10.72 9.79 19 422715 7133 64068865
Plasmacytoma 10.72 9.79 6 422728 3864 64072134
Vacuum extractor delivery 10.71 9.79 8 422726 123 64075875
Genital herpes 10.71 9.79 32 422702 1863 64074135
Myocardial ischaemia 10.69 9.79 99 422635 23152 64052846
Type 1 diabetes mellitus 10.66 9.79 13 422721 5692 64070306
Retinitis 10.66 9.79 34 422700 2051 64073947
Device related infection 10.65 9.79 139 422595 30487 64045511
Cataract 10.65 9.79 424 422310 50838 64025160
Haemolysis 10.64 9.79 115 422619 10924 64065074
Device leakage 10.64 9.79 24 422710 8242 64067756
Lung adenocarcinoma 10.63 9.79 79 422655 6754 64069244
Iron deficiency 10.61 9.79 82 422652 7095 64068903
Upper respiratory tract infection 10.60 9.79 581 422153 72204 64003794
Skin graft failure 10.58 9.79 10 422724 216 64075782
Complications of transplanted kidney 10.57 9.79 12 422722 5423 64070575
Premature baby 10.55 9.79 46 422688 3226 64072772
Skin neoplasm excision 10.54 9.79 20 422714 866 64075132
Blood iron increased 10.54 9.79 26 422708 1351 64074647
Hemiparesis 10.51 9.79 135 422599 29692 64046306
Ketoacidosis 10.50 9.79 18 422716 6845 64069153
Euglycaemic diabetic ketoacidosis 10.46 9.79 12 422722 5398 64070600
Generalised tonic-clonic seizure 10.43 9.79 191 422543 39666 64036332
Injection site haemorrhage 10.40 9.79 220 422514 24058 64051940
Acute generalised exanthematous pustulosis 10.39 9.79 52 422682 14006 64061992
Cryptorchism 10.37 9.79 5 422729 32 64075966
Head injury 10.37 9.79 152 422582 32690 64043308
Hepatic cytolysis 10.37 9.79 52 422682 13997 64062001
Radiation inflammation 10.36 9.79 10 422724 222 64075776
Affective disorder 10.30 9.79 17 422717 6563 64069435
Visual acuity reduced 10.26 9.79 121 422613 27020 64048978
Osteochondrosis 10.26 9.79 27 422707 1460 64074538
Conjunctivitis 10.25 9.79 189 422545 20165 64055833
Mood altered 10.23 9.79 62 422672 15917 64060081
Swollen joint count 10.23 9.79 16 422718 592 64075406
Nail injury 10.21 9.79 14 422720 459 64075539
Sinusitis bacterial 10.20 9.79 23 422711 1127 64074871
Kidney infection 10.19 9.79 169 422565 17669 64058329
Acute myocardial infarction 10.18 9.79 364 422370 69354 64006644
Vascular rupture 10.16 9.79 25 422709 1297 64074701
Virologic failure 10.15 9.79 5 422729 3461 64072537
Brain herniation 10.12 9.79 17 422717 6516 64069482
Pancreatic duct stenosis 10.10 9.79 10 422724 229 64075769
Acute lymphocytic leukaemia recurrent 10.10 9.79 7 422727 4019 64071979
Coronary artery bypass 10.09 9.79 14 422720 5801 64070197
Intracranial pressure increased 10.09 9.79 19 422715 6970 64069028
Multiple allergies 10.09 9.79 14 422720 5800 64070198
Dermatitis psoriasiform 10.08 9.79 34 422700 2112 64073886
Eye infection 10.05 9.79 99 422635 9182 64066816
Coloboma 10.04 9.79 3 422731 3 64075995
Chromophobe renal cell carcinoma 10.04 9.79 3 422731 3 64075995
Cervix haematoma uterine 10.04 9.79 3 422731 3 64075995
Laryngospasm 10.04 9.79 5 422729 3440 64072558
Salivary hypersecretion 10.03 9.79 43 422691 12070 64063928
Reticulocyte count increased 10.01 9.79 23 422711 1141 64074857
Product preparation error 10.00 9.79 7 422727 3998 64072000
Ankylosing spondylitis 10.00 9.79 90 422644 8144 64067854
Umbilical hernia 9.97 9.79 56 422678 4349 64071649
Benign ovarian tumour 9.97 9.79 11 422723 287 64075711
Pneumobilia 9.97 9.79 9 422725 183 64075815
Cartilage injury 9.95 9.79 25 422709 1314 64074684
Skin infection 9.94 9.79 146 422588 14891 64061107
Epstein-Barr virus infection 9.93 9.79 45 422689 12443 64063555
Lip blister 9.92 9.79 35 422699 2224 64073774
Epstein-Barr virus associated lymphoproliferative disorder 9.92 9.79 4 422730 3115 64072883
Polyneuropathy 9.90 9.79 83 422651 19811 64056187
Scleroedema 9.89 9.79 5 422729 36 64075962
Diverticulitis 9.87 9.79 327 422407 38291 64037707
Inadequate analgesia 9.87 9.79 7 422727 3971 64072027

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE02 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03BB01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Folic acid and derivatives
ATC B03BB51 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Folic acid and derivatives
ATC V04CX02 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Other diagnostic agents
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Vitamin deficiency indication 85670002
Iron deficiency anemia indication 87522002
Mineral deficiency indication 111379007
Folic acid deficiency indication 190633005
Pregnancy, function indication 289908002
Breastfeeding (mother) indication 413712001
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Prevention of Vitamin B12 Deficiency indication
Homocystinuria off-label use 11282001 DOID:9263
Homocystinemia off-label use 52311001
Prevention of Fetal Neural Tube Defects during Pregnancy off-label use
Peptic ulcer contraindication 13200003 DOID:750
Bipolar disorder contraindication 13746004 DOID:3312
Constipation contraindication 14760008 DOID:2089
Operation on stomach contraindication 16453004
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hemosiderosis contraindication 39011001 DOID:12119
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Diabetes mellitus contraindication 73211009 DOID:9351
Phototoxicity contraindication 84326006
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Osteolysis contraindication 203522001
Hypomania contraindication 231496004
Esophageal dysmotility contraindication 266434009 DOID:9192
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.46 acidic
pKa2 5.15 acidic
pKa3 12.96 acidic
pKa4 4.55 Basic
pKa5 4.15 Basic
pKa6 2.28 Basic
pKa7 1.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thymidylate synthase Enzyme Ki 4.40 CHEMBL
Dihydrofolate reductase Enzyme Kd 6.09 CHEMBL
Dihydrofolate reductase Enzyme Kd 6.09 CHEMBL

External reference:

IDSource
4017507 VUID
N0000145892 NUI
D00070 KEGG_DRUG
6484-89-5 SECONDARY_CAS_RN
4017507 VANDF
C0016410 UMLSCUI
CHEBI:27470 CHEBI
FA PDB_CHEM_ID
CHEMBL1622 ChEMBL_ID
CHEMBL2107429 ChEMBL_ID
D005492 MESH_DESCRIPTOR_UI
DB00158 DRUGBANK_ID
4563 IUPHAR_LIGAND_ID
68 INN_ID
935E97BOY8 UNII
135398658 PUBCHEM_CID
1300473 RXNORM
264 MMSL
4759 MMSL
d00241 MMSL
001049 NDDF
126224002 SNOMEDCT_US
6247001 SNOMEDCT_US
63718003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 1 mg ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 1 mg ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 1 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 1.40 mg ORAL unapproved drug other 15 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 1 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 1 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 1 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 1 mg ORAL Unapproved drug other 9 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 10 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 1 mg ORAL Unapproved drug other 11 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-7814 TABLET 1 mg ORAL ANDA 12 sections
Folic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-7814 TABLET 1 mg ORAL ANDA 12 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1700 ug ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 0.40 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 680 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 680 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 0.40 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 1 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 1700 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1 mg ORAL unapproved drug other 7 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 4 0642-7468 STRIP 1 mg ORAL Unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 680 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 1000 ug ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 1 mg ORAL UNAPPROVED DRUG OTHER 10 sections