flecainide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
Class I antiarrhythmics, procainamide and lidocaine derivatives	1176	54143-55-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: tambocor flecainide flecaine flecainide acetate	A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS. Molecular weight: 414.35 Formula: C17H20F6N2O3 CLOGP: 4.15 LIPINSKI: 0 HAC: 5 HDO: 2 TPSA: 59.59 ALOGS: -4.11 ROTB: 9 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tambocor
flecainide
flecaine
flecainide acetate

A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.

Molecular weight: 414.35
Formula: C17H20F6N2O3
CLOGP: 4.15
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 59.59
ALOGS: -4.11
ROTB: 9

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.20	g	O
0.20	g	P

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	12.07 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Hosey CM, Chan R, Benet LZ
S (Water solubility)	48.40 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	43 %	Hosey CM, Chan R, Benet LZ
BA (Bioavailability)	95 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	6.10 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	4.90 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.52 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	12 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Oct. 31, 1985	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Electrocardiogram QRS complex prolonged	589.81	14.77	162	16797	5776	63466287
Electrocardiogram QT prolonged	266.19	14.77	177	16782	59353	63412710
Atrial fibrillation	240.27	14.77	219	16740	116417	63355646
Bradycardia	237.60	14.77	179	16780	73048	63399015
Drug interaction	209.92	14.77	281	16678	228850	63243213
Toxicity to various agents	209.60	14.77	292	16667	246958	63225105
Ventricular tachycardia	198.66	14.77	100	16859	19879	63452184
Cardiac arrest	175.44	14.77	166	16793	92379	63379684
Arrhythmia	157.45	14.77	108	16851	38032	63434031
Atrial flutter	124.56	14.77	58	16901	9714	63462349
Torsade de pointes	115.86	14.77	61	16898	13290	63458773
Atrioventricular block first degree	114.41	14.77	50	16909	7223	63464840
Bundle branch block right	100.79	14.77	41	16918	4957	63467106
Ventricular fibrillation	82.96	14.77	47	16912	11820	63460243
Device pacing issue	80.45	14.77	15	16944	82	63471981
Rectal polyp	79.16	14.77	24	16935	1215	63470848
Hypotension	72.34	14.77	197	16762	272407	63199656
Syncope	69.96	14.77	118	16841	117267	63354796
Cardiogenic shock	69.79	14.77	49	16910	17883	63454180
Hyponatraemia	66.04	14.77	112	16847	111788	63360275
Change of bowel habit	65.71	14.77	24	16935	2169	63469894
Injection site discomfort	63.75	14.77	29	16930	4601	63467462
Bundle branch block left	63.37	14.77	33	16926	7026	63465037
Sinus bradycardia	61.89	14.77	42	16917	14509	63457554
Ventricular dyssynchrony	59.65	14.77	11	16948	56	63472007
Tachycardia	59.08	14.77	110	16849	118046	63354017
Device capturing issue	57.71	14.77	10	16949	33	63472030
Defect conduction intraventricular	56.31	14.77	12	16947	140	63471923
Thalamic infarction	56.20	14.77	15	16944	477	63471586
Intestinal haemorrhage	55.84	14.77	25	16934	3822	63468241
Sensitisation	55.60	14.77	24	16935	3362	63468701
Brugada syndrome	54.79	14.77	14	16945	374	63471689
Tachyarrhythmia	52.36	14.77	25	16934	4425	63467638
Stress cardiomyopathy	51.82	14.77	32	16927	9418	63462645
Cardiac failure	50.97	14.77	88	16871	89054	63383009
Needle issue	46.65	14.77	31	16928	10345	63461718
Urine odour abnormal	46.54	14.77	26	16933	6363	63465700
Contraindicated product administered	46.34	14.77	3	16956	217645	63254418
Completed suicide	45.48	14.77	112	16847	145561	63326502
Acute kidney injury	45.40	14.77	164	16795	263251	63208812
Cardio-respiratory arrest	44.98	14.77	67	16892	59892	63412171
Pain	44.91	14.77	81	16878	740547	62731516
Frustration tolerance decreased	44.37	14.77	26	16933	6962	63465101
Conduction disorder	43.75	14.77	16	16943	1451	63470612
Polyp	43.36	14.77	25	16934	6496	63465567
Proctalgia	42.16	14.77	24	16935	6086	63465977
Duodenal ulcer	41.86	14.77	26	16933	7730	63464333
Palpitations	40.96	14.77	92	16867	112678	63359385
Rheumatoid arthritis	40.73	14.77	9	16950	253810	63218253
Furuncle	40.56	14.77	24	16935	6542	63465521
Therapeutic product effect decreased	40.14	14.77	3	16956	193184	63278879
Sinoatrial block	39.29	14.77	13	16946	875	63471188
Urine abnormality	39.08	14.77	24	16935	6995	63465068
Cerebral venous thrombosis	38.37	14.77	16	16943	2058	63470005
Tubulointerstitial nephritis	38.20	14.77	36	16923	19867	63452196
Electrocardiogram PR prolongation	37.73	14.77	12	16947	712	63471351
Ventricular arrhythmia	37.55	14.77	19	16940	3809	63468254
Atrioventricular block	37.19	14.77	24	16935	7623	63464440
Infusion related reaction	36.87	14.77	10	16949	245511	63226552
Thyroid disorder	36.17	14.77	31	16928	15131	63456932
Bladder disorder	36.10	14.77	25	16934	8921	63463142
Intentional overdose	35.75	14.77	68	16891	74084	63397979
Drug intolerance	35.68	14.77	19	16940	308642	63163421
Bifascicular block	35.49	14.77	8	16951	123	63471940
Overdose	35.39	14.77	88	16871	114990	63357073
Bradyarrhythmia	34.76	14.77	15	16944	2100	63469963
Cutaneous T-cell lymphoma	33.69	14.77	13	16946	1367	63470696
Swelling	33.25	14.77	16	16943	275362	63196701
Wound	32.63	14.77	3	16956	163260	63308803
Systemic lupus erythematosus	32.33	14.77	8	16951	208910	63263153
Ventricular extrasystoles	32.25	14.77	26	16933	11661	63460402
Full blood count decreased	31.84	14.77	37	16922	25987	63446076
Peripheral coldness	31.33	14.77	26	16933	12139	63459924
Postoperative wound infection	29.50	14.77	24	16935	10901	63461162
Arthropathy	29.33	14.77	13	16946	234779	63237284
Electrocardiogram abnormal	28.74	14.77	22	16937	9157	63462906
Heart rate decreased	28.71	14.77	47	16912	45513	63426550
Musculoskeletal stiffness	25.05	14.77	9	16950	184609	63287454
Mass	24.37	14.77	24	16935	13976	63458087
Blood glucose decreased	24.32	14.77	29	16930	20923	63451140
Subdural haematoma	23.90	14.77	24	16935	14304	63457759
Bundle branch block	23.78	14.77	9	16950	898	63471165
Pulmonary alveolar haemorrhage	23.56	14.77	15	16944	4653	63467410
Gallbladder disorder	23.40	14.77	27	16932	18815	63453248
Electrocardiogram QT interval	23.31	14.77	6	16953	165	63471898
Device malfunction	22.87	14.77	26	16933	17831	63454232
Musculoskeletal discomfort	22.74	14.77	26	16933	17941	63454122
Slow response to stimuli	22.65	14.77	9	16950	1023	63471040
Hepatic enzyme increased	22.57	14.77	13	16946	202315	63269748
Cerebral haemorrhage	22.55	14.77	34	16925	30695	63441368
Metabolic acidosis	22.55	14.77	42	16917	45027	63427036
Pericarditis	22.48	14.77	4	16955	131575	63340488
Intracranial haematoma	22.21	14.77	7	16952	403	63471660
Subarachnoid haemorrhage	22.15	14.77	23	16936	14260	63457803
Cutaneous vasculitis	21.91	14.77	15	16944	5254	63466809
Pericardial haemorrhage	21.84	14.77	10	16949	1609	63470454
Drug-device interaction	21.39	14.77	5	16954	91	63471972
Exostosis	21.19	14.77	25	16934	17837	63454226
Dermatitis exfoliative generalised	21.15	14.77	13	16946	3794	63468269
Jaundice	20.95	14.77	32	16927	29219	63442844
Lung neoplasm malignant	20.88	14.77	26	16933	19607	63452456
Hypersensitivity	20.49	14.77	29	16930	292656	63179407
Shock	20.19	14.77	28	16931	23435	63448628
Cardiac failure acute	19.77	14.77	18	16941	9505	63462558
Heart rate irregular	19.66	14.77	27	16932	22394	63449669
Pacemaker syndrome	19.61	14.77	3	16956	3	63472060
Alopecia	19.41	14.77	38	16921	337498	63134565
Injection site mass	18.72	14.77	24	16935	18632	63453431
Dizziness	18.68	14.77	186	16773	429739	63042324
Supraventricular tachycardia	18.65	14.77	21	16938	14250	63457813
Hypokalaemia	18.15	14.77	65	16894	103739	63368324
Presyncope	17.96	14.77	29	16930	27756	63444307
Arthralgia	17.81	14.77	85	16874	569625	62902438
Rash pustular	17.59	14.77	15	16944	7267	63464796
Extrasystoles	17.56	14.77	13	16946	5147	63466916
Unresponsive to stimuli	17.52	14.77	32	16927	33784	63438279
Accidental overdose	17.40	14.77	26	16933	23283	63448780
Sinusitis	17.35	14.77	21	16938	226632	63245431
Medication error	17.14	14.77	41	16918	52243	63419820
Weight increased	17.13	14.77	27	16932	260765	63211298
Neovascular age-related macular degeneration	16.99	14.77	5	16954	228	63471835
Antisynthetase syndrome	16.85	14.77	4	16955	78	63471985
Drug-disease interaction	16.65	14.77	6	16953	522	63471541
Blister	16.50	14.77	7	16952	129807	63342256
Drug level increased	16.46	14.77	25	16934	22711	63449352
Cardiac ablation	16.43	14.77	8	16951	1477	63470586
Sinus node dysfunction	16.38	14.77	12	16947	4673	63467390
Mobility decreased	16.27	14.77	6	16953	121153	63350910
Mixed liver injury	16.27	14.77	12	16947	4723	63467340
Bone disorder	16.22	14.77	24	16935	21302	63450761
Urinary incontinence	16.22	14.77	30	16929	31984	63440079
Rash	16.20	14.77	86	16873	560785	62911278
Hyperkalaemia	16.18	14.77	41	16918	54162	63417901
Drug level above therapeutic	16.11	14.77	12	16947	4793	63467270
Discomfort	15.68	14.77	13	16946	167361	63304702
Hepatocellular injury	15.59	14.77	27	16932	27354	63444709
Coma	15.51	14.77	45	16914	64319	63407744
Lower respiratory tract infection	15.48	14.77	8	16951	132299	63339764
Hyperammonaemic encephalopathy	15.30	14.77	9	16950	2425	63469638
Limb discomfort	15.25	14.77	28	16931	29688	63442375
Nodal arrhythmia	15.12	14.77	7	16952	1156	63470907
Bicytopenia	15.06	14.77	9	16950	2496	63469567
Cerebral congestion	14.89	14.77	3	16956	26	63472037
Gravitational oedema	14.83	14.77	7	16952	1207	63470856
Ischaemic stroke	14.81	14.77	21	16938	17936	63454127

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Electrocardiogram QRS complex prolonged	287.58	14.80	92	10741	4802	34941296
Bradycardia	189.70	14.80	169	10664	75249	34870849
Brugada syndrome	158.54	14.80	39	10794	762	34945336
Atrial fibrillation	113.32	14.80	163	10670	122230	34823868
Ventricular tachycardia	112.64	14.80	81	10752	26498	34919600
Atrial flutter	106.42	14.80	64	10769	15510	34930588
Toxicity to various agents	67.97	14.80	174	10659	200188	34745910
Electrocardiogram QT prolonged	65.83	14.80	72	10761	40880	34905218
Atrioventricular block first degree	57.68	14.80	31	10802	6061	34940037
Hypotension	56.93	14.80	174	10659	221475	34724623
Tachyarrhythmia	50.74	14.80	24	10809	3584	34942514
Syncope	49.68	14.80	96	10737	91355	34854743
Hydrops foetalis	49.67	14.80	16	10817	851	34945247
Bundle branch block right	49.04	14.80	30	10803	7486	34938612
Cardiac arrest	48.68	14.80	98	10735	96061	34850037
Tachycardia	44.83	14.80	88	10745	84684	34861414
Electrocardiogram PR prolongation	41.19	14.80	14	10819	881	34945217
Electrocardiogram abnormal	41.02	14.80	29	10804	9218	34936880
Intentional overdose	38.58	14.80	57	10776	43617	34902481
Drug interaction	38.53	14.80	155	10678	225791	34720307
Cardiac flutter	37.82	14.80	16	10817	1837	34944261
Atrioventricular block	37.43	14.80	26	10807	8037	34938061
Interstitial lung disease	34.77	14.80	68	10765	65214	34880884
Atrioventricular block complete	34.05	14.80	26	10807	9293	34936805
High frequency ablation	31.61	14.80	8	10825	176	34945922
Electrocardiogram QRS complex shortened	31.23	14.80	8	10825	185	34945913
Ventricular fibrillation	31.17	14.80	37	10796	22917	34923181
Drug level increased	30.63	14.80	36	10797	22060	34924038
Sinus bradycardia	30.41	14.80	28	10805	12935	34933163
Supraventricular tachycardia	30.02	14.80	26	10807	11091	34935007
Amaurosis	28.64	14.80	10	10823	682	34945416
Overdose	26.63	14.80	75	10758	90984	34855114
Defect conduction intraventricular	26.04	14.80	8	10825	364	34945734
Electrocardiogram QRS complex abnormal	26.04	14.80	8	10825	364	34945734
Overflow diarrhoea	24.77	14.80	5	10828	37	34946061
Splenic rupture	23.99	14.80	11	10822	1530	34944568
Pulseless electrical activity	23.91	14.80	19	10814	7192	34938906
Arrhythmia	23.72	14.80	41	10792	35767	34910331
Device pacing issue	23.61	14.80	5	10828	48	34946050
Suicide attempt	22.36	14.80	42	10791	39074	34907024
Lentigo maligna	21.94	14.80	7	10826	361	34945737
Gastrointestinal ischaemia	20.93	14.80	6	10827	214	34945884
Palpitations	20.49	14.80	41	10792	39945	34906153
Bradyarrhythmia	20.32	14.80	11	10822	2180	34943918
Accidental overdose	20.29	14.80	28	10805	20112	34925986
Microcytic anaemia	19.38	14.80	11	10822	2389	34943709
Device capturing issue	19.16	14.80	3	10830	3	34946095
Pelvic pain	19.05	14.80	11	10822	2469	34943629
Heart rate	18.93	14.80	4	10829	38	34946060
Acute respiratory distress syndrome	18.88	14.80	31	10802	25938	34920160
Tachycardia foetal	18.31	14.80	6	10827	337	34945761
Reflexes abnormal	18.26	14.80	6	10827	340	34945758
Peripheral T-cell lymphoma unspecified recurrent	18.23	14.80	4	10829	46	34946052
Hypomania	16.89	14.80	10	10823	2349	34943749
Pleurothotonus	16.89	14.80	8	10825	1197	34944901
Retinal vascular occlusion	16.82	14.80	5	10828	203	34945895
Hypoglycaemic coma	16.62	14.80	10	10823	2421	34943677
Vertigo	16.60	14.80	29	10804	25507	34920591
Shock haemorrhagic	16.57	14.80	19	10814	11335	34934763
Completed suicide	16.38	14.80	67	10766	98101	34847997
Foetal exposure during pregnancy	15.97	14.80	36	10797	38065	34908033
Torsade de pointes	15.81	14.80	15	10818	7194	34938904
Ventricular dyssynchrony	15.71	14.80	3	10830	16	34946082
BRASH syndrome	15.58	14.80	6	10827	540	34945558
Eosinophilic pneumonia	15.57	14.80	11	10822	3490	34942608
Panic reaction	15.36	14.80	8	10825	1467	34944631
Calcium ionised increased	15.14	14.80	3	10830	20	34946078

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Electrocardiogram QRS complex prolonged	736.79	13.40	228	24634	10605	79708921
Bradycardia	385.96	13.40	327	24535	135230	79584296
Ventricular tachycardia	300.41	13.40	178	24684	41757	79677769
Atrial fibrillation	289.91	13.40	332	24530	197554	79521972
Electrocardiogram QT prolonged	261.03	13.40	220	24642	90166	79629360
Toxicity to various agents	212.94	13.40	430	24432	421110	79298416
Atrial flutter	209.70	13.40	112	24750	21513	79698013
Brugada syndrome	203.41	13.40	52	24810	1186	79718340
Cardiac arrest	192.26	13.40	252	24610	171844	79547682
Drug interaction	173.19	13.40	392	24470	414791	79304735
Arrhythmia	146.40	13.40	134	24728	61138	79658388
Atrioventricular block first degree	142.02	13.40	72	24790	12419	79707107
Bundle branch block right	128.35	13.40	65	24797	11186	79708340
Torsade de pointes	115.26	13.40	73	24789	19239	79700287
Syncope	113.72	13.40	202	24660	179247	79540279
Hypotension	107.39	13.40	341	24521	439976	79279550
Tachycardia	99.87	13.40	190	24672	177578	79541948
Tachyarrhythmia	99.74	13.40	47	24815	6915	79712611
Ventricular fibrillation	98.87	13.40	81	24781	31845	79687681
Device pacing issue	84.94	13.40	17	24845	119	79719407
Sinus bradycardia	84.42	13.40	67	24795	25180	79694346
Device capturing issue	75.54	13.40	13	24849	33	79719493
Bundle branch block left	74.96	13.40	46	24816	11467	79708059
Atrioventricular block	73.77	13.40	49	24813	13992	79705534
Intentional overdose	73.22	13.40	124	24738	105836	79613690
Rectal polyp	72.22	13.40	25	24837	1652	79717874
Electrocardiogram abnormal	68.25	13.40	50	24812	16687	79702839
Cardiogenic shock	67.45	13.40	74	24788	41840	79677686
Ventricular dyssynchrony	61.42	13.40	12	24850	73	79719453
Overdose	60.55	13.40	159	24703	184047	79535479
Change of bowel habit	60.13	13.40	25	24837	2732	79716794
Injection site discomfort	56.46	13.40	29	24833	5137	79714389
Bradyarrhythmia	53.34	13.40	26	24836	4120	79715406
Sensitisation	52.55	13.40	24	24838	3287	79716239
Completed suicide	52.30	13.40	182	24680	245585	79473941
Electrocardiogram PR prolongation	50.86	13.40	19	24843	1564	79717962
Defect conduction intraventricular	48.77	13.40	14	24848	499	79719027
Palpitations	48.64	13.40	116	24746	126494	79593032
Hyponatraemia	47.13	13.40	142	24720	177706	79541820
Intestinal haemorrhage	45.24	13.40	27	24835	6399	79713127
Drug level increased	44.06	13.40	58	24804	39593	79679933
Stress cardiomyopathy	42.49	13.40	32	24830	11134	79708392
Thyroid disorder	42.07	13.40	35	24827	14044	79705482
Thalamic infarction	39.50	13.40	15	24847	1292	79718234
Pain	38.80	13.40	103	24759	703699	79015827
Rheumatoid arthritis	38.26	13.40	9	24853	208461	79511065
Urine odour abnormal	38.14	13.40	24	24838	6249	79713277
Atrioventricular block complete	37.08	13.40	35	24827	16575	79702951
Frustration tolerance decreased	36.58	13.40	25	24837	7477	79712049
Needle issue	36.00	13.40	31	24831	13037	79706489
Cardio-respiratory arrest	34.95	13.40	93	24769	108417	79611109
Cardiac failure	34.95	13.40	117	24745	154725	79564801
Polyp	34.83	13.40	25	24837	8082	79711444
Bladder disorder	34.28	13.40	26	24836	9139	79710387
Furuncle	34.08	13.40	24	24838	7530	79711996
Ventricular extrasystoles	33.82	13.40	36	24826	19668	79699858
Infusion related reaction	33.36	13.40	15	24847	230222	79489304
Therapeutic product effect decreased	32.28	13.40	6	24856	163857	79555669
Proctalgia	32.27	13.40	26	24836	9975	79709551
Urine abnormality	32.26	13.40	24	24838	8195	79711331
Sinoatrial block	32.01	13.40	13	24849	1338	79718188
Pulseless electrical activity	31.92	13.40	30	24832	14130	79705396
Cerebral venous thrombosis	31.67	13.40	16	24846	2737	79716789
Drug intolerance	31.38	13.40	22	24840	264097	79455429
Accidental overdose	30.94	13.40	49	24813	39532	79679994
Bifascicular block	30.35	13.40	9	24853	360	79719166
Swelling	30.04	13.40	15	24847	216696	79502830
Interstitial lung disease	29.90	13.40	90	24772	112510	79607016
Musculoskeletal stiffness	29.39	13.40	9	24853	174999	79544527
Electrocardiogram QRS complex shortened	28.06	13.40	10	24852	720	79718806
Cardiac flutter	27.75	13.40	18	24844	4936	79714590
Acute kidney injury	27.67	13.40	265	24597	519139	79200387
High frequency ablation	27.61	13.40	8	24854	295	79719231
Peripheral coldness	27.09	13.40	29	24833	15941	79703585
Tubulointerstitial nephritis	26.72	13.40	45	24817	38190	79681336
Bundle branch block	26.67	13.40	12	24850	1588	79717938
International normalised ratio increased	26.66	13.40	72	24790	84649	79634877
Ventricular arrhythmia	26.46	13.40	22	24840	8818	79710708
Cutaneous T-cell lymphoma	26.19	13.40	14	24848	2689	79716837
Conduction disorder	25.90	13.40	15	24847	3364	79716162
Cardiotoxicity	25.82	13.40	25	24837	12214	79707312
Cardiac ablation	25.64	13.40	13	24849	2240	79717286
Suicide attempt	25.61	13.40	70	24792	82862	79636664
Electrocardiogram QRS complex abnormal	25.57	13.40	9	24853	625	79718901
Hyperkalaemia	25.41	13.40	86	24776	114312	79605214
Loss of consciousness	24.83	13.40	111	24751	167832	79551694
Duodenal ulcer	24.78	13.40	28	24834	16341	79703185
Subdural haematoma	24.68	13.40	39	24823	31395	79688131
Postoperative wound infection	24.61	13.40	25	24837	12936	79706590
Pericardial haemorrhage	24.37	13.40	16	24846	4479	79715047
Full blood count decreased	23.49	13.40	35	24827	26784	79692742
Extrasystoles	23.33	13.40	19	24843	7400	79712126
Amaurosis	23.31	13.40	10	24852	1181	79718345
Nasopharyngitis	23.17	13.40	27	24835	253854	79465672
Weight increased	22.73	13.40	32	24830	277354	79442172
Medication error	22.26	13.40	59	24803	68583	79650943
Glossodynia	22.11	13.40	3	24859	103334	79616192
Atrial tachycardia	21.87	13.40	18	24844	7115	79712411
Contraindicated product administered	21.69	13.40	11	24851	157527	79561999
Heart rate decreased	21.36	13.40	59	24803	70257	79649269
Wound	21.34	13.40	5	24857	116174	79603352
Unresponsive to stimuli	21.28	13.40	51	24811	55737	79663789
Gallbladder disorder	21.03	13.40	28	24834	19312	79700214
Sinus node dysfunction	20.67	13.40	18	24844	7683	79711843
Drug level above therapeutic	20.66	13.40	19	24843	8704	79710822
Hepatic enzyme increased	20.66	13.40	16	24846	182594	79536932
Dizziness	20.34	13.40	252	24610	526189	79193337
Shock	20.17	13.40	43	24819	43505	79676021
Lower respiratory tract infection	19.38	13.40	8	24854	129212	79590314
Mobility decreased	19.25	13.40	7	24855	122168	79597358
Asthma	19.25	13.40	9	24853	135086	79584440
Slow response to stimuli	19.24	13.40	10	24852	1815	79717711
Pacemaker syndrome	19.14	13.40	3	24859	3	79719523
Membrane stabilising effect	19.14	13.40	3	24859	3	79719523
Supraventricular tachycardia	18.97	13.40	28	24834	21242	79698284
Hypoglycaemic coma	18.91	13.40	14	24848	4746	79714780
Hypersensitivity	18.87	13.40	33	24829	262206	79457320
Cardiac disorder	18.82	13.40	54	24808	65703	79653823
Device malfunction	18.79	13.40	28	24834	21420	79698106
Nodal arrhythmia	18.48	13.40	10	24852	1968	79717558
Peripheral T-cell lymphoma unspecified recurrent	18.13	13.40	4	24858	47	79719479
Cardioversion	17.93	13.40	10	24852	2088	79717438
Cardiac tamponade	17.81	13.40	18	24844	9258	79710268
Arthralgia	17.80	13.40	105	24757	571698	79147828
Overflow diarrhoea	17.73	13.40	5	24857	167	79719359
Stomatitis	17.72	13.40	12	24850	146745	79572781
Exostosis	17.71	13.40	24	24838	16834	79702692
Cutaneous vasculitis	17.68	13.40	17	24845	8235	79711291
Microcytic anaemia	17.63	13.40	14	24848	5260	79714266
Musculoskeletal discomfort	17.53	13.40	26	24836	19809	79699717
Electrocardiogram T wave inversion	17.41	13.40	14	24848	5358	79714168
Neovascular age-related macular degeneration	17.31	13.40	6	24856	398	79719128
Poisoning deliberate	17.10	13.40	25	24837	18803	79700723
Mass	17.05	13.40	24	24838	17448	79702078
Splenic rupture	16.57	13.40	10	24852	2419	79717107
Sinusitis	16.56	13.40	22	24840	195479	79524047
Therapeutic product effect incomplete	16.55	13.40	12	24850	141633	79577893
Blood pressure systolic increased	16.34	13.40	52	24810	66934	79652592
Cerebral haematoma	16.33	13.40	16	24846	7926	79711600
C-reactive protein increased	16.33	13.40	10	24852	129017	79590509
Cerebral haemorrhage	16.16	13.40	47	24815	57626	79661900
Gastrointestinal ischaemia	16.09	13.40	6	24856	491	79719035
Haematoma	16.06	13.40	44	24818	52151	79667375
Subarachnoid haemorrhage	16.05	13.40	28	24834	24437	79695089
Lung neoplasm malignant	15.93	13.40	30	24832	27762	79691764
Drug-device interaction	15.78	13.40	4	24858	88	79719438
Rectal haemorrhage	15.75	13.40	56	24806	76244	79643282
Ischaemic stroke	15.67	13.40	33	24829	33098	79686428
Haemorrhage	15.61	13.40	63	24799	91055	79628471
Discomfort	15.53	13.40	10	24852	125607	79593919
Intracranial haematoma	15.51	13.40	7	24855	933	79718593
Reflexes abnormal	15.49	13.40	7	24855	936	79718590
Unmasking of previously unidentified disease	15.42	13.40	9	24853	2048	79717478
Bone disorder	15.40	13.40	24	24838	19089	79700437
Lentigo maligna	15.38	13.40	6	24856	556	79718970
Hypertensive crisis	15.25	13.40	25	24837	20745	79698781
Coma	15.23	13.40	67	24795	100582	79618944
Mixed liver injury	15.09	13.40	15	24847	7563	79711963
Rash	15.07	13.40	112	24750	578246	79141280
Respiratory acidosis	15.02	13.40	18	24844	11182	79708344
Alopecia	14.99	13.40	31	24831	231324	79488202
Arthropathy	14.93	13.40	20	24842	177091	79542435
Heart rate	14.93	13.40	4	24858	110	79719416
Blood glucose decreased	14.65	13.40	28	24834	26206	79693320
Vertigo	14.52	13.40	51	24811	69031	79650495
Systemic lupus erythematosus	14.50	13.40	10	24852	121139	79598387
Injection site mass	14.43	13.40	24	24838	20160	79699366
Acute respiratory distress syndrome	14.41	13.40	38	24824	44029	79675497
Hypokalaemia	14.17	13.40	85	24777	143955	79575571
Atrial conduction time prolongation	14.13	13.40	3	24859	29	79719497
Dermatitis exfoliative generalised	13.81	13.40	14	24848	7227	79712299
Vomiting	13.76	13.40	137	24725	665691	79053835

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C01BC04	CARDIOVASCULAR SYSTEM CARDIAC THERAPY ANTIARRHYTHMICS, CLASS I AND III Antiarrhythmics, class Ic
FDA EPC	N0000175426	Antiarrhythmic
CHEBI has role	CHEBI:38070	antiarrhythmic agent
MeSH PA	D000889	Anti-Arrhythmia Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D026941	Sodium Channel Blockers
MeSH PA	D061567	Voltage-Gated Sodium Channel Blockers

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Atrial fibrillation	indication	49436004	DOID:0060224
Paroxysmal atrial fibrillation	indication	282825002
Paroxysmal atrial flutter	indication	427665004
Prevention of Paroxysmal Supraventricular Tachycardia	indication
Life-Threatening Ventricular Tachycardia	indication
Cardioversion of Atrial Fibrillation	off-label use
Hyperkalemia	contraindication	14140009
Myocardial infarction	contraindication	22298006	DOID:5844
Complete atrioventricular block	contraindication	27885002
Sick sinus syndrome	contraindication	36083008	DOID:13884
Hypokalemia	contraindication	43339004
Chronic heart failure	contraindication	48447003
Cardiogenic shock	contraindication	89138009
Kidney disease	contraindication	90708001	DOID:557
Second degree atrioventricular block	contraindication	195042002
Disease of liver	contraindication	235856003	DOID:409
Smokes tobacco daily	contraindication	449868002
Right Bundle Branch Block with Left Hemiblock	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.78	acidic
pKa2	8.94	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Sodium channel protein type 5 subunit alpha	Ion channel	Q14524	SCN5A_HUMAN	BLOCKER	IC50	5.19	CHEMBL	CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	5.41	CHEMBL
Sodium channel protein type 4 subunit alpha	Ion channel	P35499	SCN4A_HUMAN		Ki	4.75	WOMBAT-PK
Potassium voltage-gated channel subfamily A member 5	Ion channel	P22460	KCNA5_HUMAN	BLOCKER	Kd	4	IUPHAR
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Ion channel	Q9Y3Q4	HCN4_HUMAN		IC50	2.77	WOMBAT-PK
Potassium voltage-gated channel subfamily A member 7	Ion channel	Q96RP8	KCNA7_HUMAN	BLOCKER	Kd	5.10	IUPHAR
Potassium voltage-gated channel subfamily D member 2	Ion channel		KCND2_RAT		IC50	5	CHEMBL
Potassium voltage-gated channel subfamily C member 1	Ion channel		KCNC1_MOUSE	BLOCKER	IC50	4	IUPHAR

External reference:

ID	Source
D00638	KEGG_DRUG
54143-56-5	SECONDARY_CAS_RN
4018822	VANDF
4019757	VANDF
C0016229	UMLSCUI
CHEBI:75984	CHEBI
K4D	PDB_CHEM_ID
CHEMBL652	ChEMBL_ID
CHEMBL398673	ChEMBL_ID
CHEMBL1200822	ChEMBL_ID
D005424	MESH_DESCRIPTOR_UI
DB01195	DRUGBANK_ID
3356	PUBCHEM_CID
2560	IUPHAR_LIGAND_ID
4096	INN_ID
K94FTS1806	UNII
152403	RXNORM
2279	MMSL
43018	MMSL
4730	MMSL
d00234	MMSL
000628	NDDF
004483	NDDF
372751001	SNOMEDCT_US
46576005	SNOMEDCT_US
8886003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0010	TABLET	50 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0010	TABLET	50 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0011	TABLET	100 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0011	TABLET	100 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0012	TABLET	150 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0012	TABLET	150 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	42806-817	TABLET	50 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	42806-817	TABLET	50 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	42806-818	TABLET	100 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	42806-818	TABLET	100 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	42806-819	TABLET	150 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	42806-819	TABLET	150 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1132	TABLET	50 mg	ORAL	ANDA	18 sections
Flecainide Acetate	Human Prescription Drug Label	1	50090-2233	TABLET	100 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2968	TABLET	100 mg	ORAL	ANDA	19 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2968	TABLET	100 mg	ORAL	ANDA	19 sections
Flecainide Acetate	Human Prescription Drug Label	1	50090-5267	TABLET	100 mg	ORAL	ANDA	18 sections
Flecainide Acetate	Human Prescription Drug Label	1	50090-5267	TABLET	100 mg	ORAL	ANDA	18 sections
Flecainide Acetate	Human Prescription Drug Label	1	50090-5306	TABLET	50 mg	ORAL	ANDA	18 sections
Flecainide Acetate	Human Prescription Drug Label	1	50090-5306	TABLET	50 mg	ORAL	ANDA	18 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	50090-6035	TABLET	50 mg	ORAL	ANDA	19 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	50268-320	TABLET	50 mg	ORAL	ANDA	12 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	50268-321	TABLET	100 mg	ORAL	ANDA	12 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	50268-322	TABLET	150 mg	ORAL	ANDA	12 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	51407-018	TABLET	50 mg	ORAL	ANDA	19 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	51407-018	TABLET	50 mg	ORAL	ANDA	19 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	51407-019	TABLET	100 mg	ORAL	ANDA	19 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	51407-019	TABLET	100 mg	ORAL	ANDA	19 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	51407-020	TABLET	150 mg	ORAL	ANDA	19 sections
Flecainide Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	51407-020	TABLET	150 mg	ORAL	ANDA	19 sections