flecainide ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Class I antiarrhythmics, procainamide and lidocaine derivatives 1176 54143-55-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tambocor
  • flecainide
  • flecaine
  • flecainide acetate
A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
  • Molecular weight: 414.35
  • Formula: C17H20F6N2O3
  • CLOGP: 4.15
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 59.59
  • ALOGS: -4.11
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 12.07 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
S (Water solubility) 48.40 mg/mL Hosey CM, Chan R, Benet LZ
EoM (Fraction excreted unchanged in urine) 43 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 95 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 6.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.52 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 31, 1985 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Electrocardiogram QRS complex prolonged 510.86 14.90 143 14067 5201 50585713
Electrocardiogram QT prolonged 248.39 14.90 164 14046 51722 50539192
Bradycardia 220.82 14.90 166 14044 64260 50526654
Drug interaction 199.57 14.90 262 13948 199359 50391555
Atrial fibrillation 191.90 14.90 186 14024 101559 50489355
Toxicity to various agents 172.01 14.90 252 13958 212247 50378667
Cardiac arrest 165.37 14.90 157 14053 83494 50507420
Ventricular tachycardia 164.65 14.90 83 14127 15738 50575176
Arrhythmia 156.68 14.90 104 14106 33028 50557886
Torsade de pointes 117.04 14.90 60 14150 11775 50579139
Atrioventricular block first degree 113.01 14.90 48 14162 6153 50584761
Bundle branch block right 98.29 14.90 40 14170 4605 50586309
Atrial flutter 97.13 14.90 48 14162 8715 50582199
Ventricular fibrillation 85.91 14.90 47 14163 10512 50580402
Device pacing issue 82.78 14.90 15 14195 64 50590850
Hypotension 68.88 14.90 182 14028 235287 50355627
Hyponatraemia 66.20 14.90 106 14104 96033 50494881
Cardiogenic shock 64.27 14.90 45 14165 15554 50575360
Ventricular dyssynchrony 58.18 14.90 10 14200 29 50590885
Device capturing issue 57.93 14.90 10 14200 30 50590884
Thalamic infarction 56.88 14.90 15 14195 432 50590482
Defect conduction intraventricular 53.56 14.90 11 14199 100 50590814
Syncope 53.15 14.90 100 14110 102902 50488012
Stress cardiomyopathy 53.05 14.90 31 14179 7856 50583058
Sinus bradycardia 51.92 14.90 37 14173 13146 50577768
Brugada syndrome 51.37 14.90 13 14197 317 50590597
Tachyarrhythmia 50.03 14.90 24 14186 4081 50586833
Acute kidney injury 47.24 14.90 156 14054 227902 50363012
Completed suicide 45.88 14.90 109 14101 131780 50459134
Conduction disorder 44.76 14.90 16 14194 1292 50589622
Pain 44.14 14.90 59 14151 578844 50012070
Palpitations 42.97 14.90 87 14123 94419 50496495
Cardio-respiratory arrest 42.07 14.90 63 14147 53829 50537085
Bundle branch block left 40.62 14.90 24 14186 6206 50584708
Sinoatrial block 40.39 14.90 13 14197 762 50590152
Ventricular arrhythmia 39.28 14.90 19 14191 3290 50587624
Cerebral venous thrombosis 39.19 14.90 16 14194 1855 50589059
Tubulointerstitial nephritis 38.77 14.90 33 14177 15178 50575736
Overdose 37.50 14.90 85 14125 99642 50491272
Atrioventricular block 37.19 14.90 23 14187 6455 50584459
Cardiac failure 36.96 14.90 72 14138 75968 50514946
Bradyarrhythmia 35.66 14.90 15 14195 1875 50589039
Tachycardia 35.27 14.90 83 14127 99680 50491234
Bifascicular block 35.16 14.90 8 14202 122 50590792
Cutaneous T-cell lymphoma 34.17 14.90 13 14197 1251 50589663
Electrocardiogram PR prolongation 34.06 14.90 11 14199 652 50590262
Intentional overdose 32.61 14.90 61 14149 62443 50528471
Electrocardiogram abnormal 31.46 14.90 22 14188 7583 50583331
Rheumatoid arthritis 31.36 14.90 9 14201 202541 50388373
Contraindicated product administered 30.98 14.90 3 14207 148955 50441959
Rectal polyp 30.06 14.90 11 14199 950 50589964
Injection site discomfort 28.44 14.90 16 14194 3774 50587140
Drug intolerance 28.40 14.90 13 14197 219091 50371823
Therapeutic product effect decreased 27.61 14.90 3 14207 136047 50454867
Medication error 26.46 14.90 41 14169 36063 50554851
Metabolic acidosis 25.58 14.90 42 14168 38783 50552131
Pulmonary alveolar haemorrhage 24.92 14.90 15 14195 4012 50586902
Sensitisation 24.75 14.90 11 14199 1571 50589343
Bundle branch block 24.31 14.90 9 14201 803 50590111
Slow response to stimuli 23.72 14.90 9 14201 860 50590054
Infusion related reaction 23.67 14.90 9 14201 169548 50421366
Device malfunction 23.58 14.90 25 14185 15096 50575818
Change of bowel habit 23.49 14.90 11 14199 1773 50589141
Ventricular extrasystoles 23.16 14.90 21 14189 10495 50580419
Subdural haematoma 23.08 14.90 23 14187 12924 50577990
Dermatitis exfoliative generalised 22.92 14.90 13 14197 3113 50587801
Intracranial haematoma 22.86 14.90 7 14203 348 50590566
Subarachnoid haemorrhage 22.72 14.90 21 14189 10755 50580159
Arthralgia 22.42 14.90 57 14153 438645 50152269
Pericardial haemorrhage 22.37 14.90 10 14200 1448 50589466
Swelling 21.60 14.90 15 14195 200857 50390057
Drug-device interaction 21.46 14.90 5 14205 85 50590829
Needle issue 21.07 14.90 17 14193 7258 50583656
Heart rate irregular 20.14 14.90 26 14184 19334 50571580
Intestinal haemorrhage 20.08 14.90 12 14198 3168 50587746
Wound 19.85 14.90 3 14207 105791 50485123
Pacemaker syndrome 19.46 14.90 3 14207 3 50590911
Mixed liver injury 19.17 14.90 12 14198 3439 50587475
Drug-disease interaction 18.89 14.90 6 14204 337 50590577
Systemic lupus erythematosus 18.75 14.90 8 14202 140614 50450300
Dizziness 18.06 14.90 162 14048 346207 50244707
Drug level above therapeutic 17.77 14.90 12 14198 3908 50587006
Musculoskeletal stiffness 17.63 14.90 7 14203 128474 50462440
Phospholipidosis 17.58 14.90 4 14206 61 50590853
Cerebral haemorrhage 17.46 14.90 29 14181 27023 50563891
Anaemia macrocytic 17.05 14.90 10 14200 2549 50588365
Accidental overdose 16.92 14.90 24 14186 19509 50571405
Bicytopenia 16.81 14.90 9 14201 1927 50588987
Arthropathy 16.69 14.90 12 14198 157894 50433020
Urine odour abnormal 16.51 14.90 13 14197 5360 50585554
Rash pustular 16.39 14.90 14 14196 6467 50584447
Electrocardiogram QT interval 16.20 14.90 4 14206 88 50590826
Cholestasis 16.09 14.90 27 14183 25374 50565540
Ischaemic stroke 15.94 14.90 21 14189 15927 50574987
Extrasystoles 15.92 14.90 12 14198 4643 50586271
Hyperkalaemia 15.89 14.90 39 14171 48050 50542864
Frustration tolerance decreased 15.89 14.90 13 14197 5661 50585253
Heart rate decreased 15.86 14.90 33 14177 36464 50554450
Joint swelling 15.73 14.90 28 14182 245258 50345656
Cerebral congestion 15.56 14.90 3 14207 19 50590895
Sinus node dysfunction 15.34 14.90 11 14199 3944 50586970
Cerebral haematoma 14.97 14.90 10 14200 3201 50587713

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Electrocardiogram QRS complex prolonged 229.30 15.42 75 9462 4035 29560955
Bradycardia 179.76 15.42 157 9380 65472 29499518
Brugada syndrome 136.74 15.42 34 9503 667 29564323
Ventricular tachycardia 112.16 15.42 77 9460 22497 29542493
Atrial flutter 105.55 15.42 62 9475 13832 29551158
Atrial fibrillation 104.14 15.42 148 9389 105498 29459492
Electrocardiogram QT prolonged 60.26 15.42 66 9471 36071 29528919
Tachyarrhythmia 54.30 15.42 24 9513 2945 29562045
Atrioventricular block first degree 51.95 15.42 28 9509 5291 29559699
Toxicity to various agents 49.37 15.42 145 9392 173516 29391474
Tachycardia 47.08 15.42 84 9453 72326 29492664
Electrocardiogram abnormal 46.14 15.42 29 9508 7293 29557697
Hypotension 43.98 15.42 150 9387 194204 29370786
Syncope 42.52 15.42 86 9451 81285 29483705
Cardiac flutter 38.82 15.42 16 9521 1654 29563336
Bundle branch block right 38.34 15.42 25 9512 6692 29558298
Ventricular fibrillation 37.53 15.42 35 9502 15798 29549192
Cardiac arrest 37.26 15.42 84 9453 85507 29479483
Drug interaction 35.11 15.42 141 9396 197244 29367746
Electrocardiogram QRS complex shortened 32.26 15.42 8 9529 155 29564835
High frequency ablation 31.65 15.42 8 9529 168 29564822
Electrocardiogram PR prolongation 31.51 15.42 11 9526 720 29564270
Intentional overdose 30.73 15.42 49 9488 38479 29526511
Overdose 30.01 15.42 74 9463 79745 29485245
Atrioventricular block complete 29.89 15.42 23 9514 7988 29557002
Amaurosis 29.33 15.42 10 9527 610 29564380
Drug level increased 29.03 15.42 33 9504 18754 29546236
Interstitial lung disease 28.93 15.42 60 9477 57658 29507332
Electrocardiogram QRS complex abnormal 27.21 15.42 8 9529 300 29564690
Device pacing issue 26.78 15.42 5 9532 22 29564968
Supraventricular tachycardia 25.66 15.42 23 9514 9861 29555129
Arrhythmia 25.21 15.42 40 9497 31273 29533717
Pulseless electrical activity 25.17 15.42 19 9518 6415 29558575
Defect conduction intraventricular 24.85 15.42 7 9530 225 29564765
Atrioventricular block 23.79 15.42 19 9518 6963 29558027
Splenic rupture 21.13 15.42 10 9527 1436 29563554
Device capturing issue 21.12 15.42 3 9534 0 29564990
Acute respiratory distress syndrome 20.85 15.42 31 9506 22904 29542086
Accidental overdose 20.82 15.42 27 9510 17566 29547424
Sinus bradycardia 20.73 15.42 22 9515 11581 29553409
Microcytic anaemia 20.69 15.42 11 9526 2020 29562970
Cardiogenic shock 20.48 15.42 28 9509 19162 29545828
Pelvic pain 20.45 15.42 11 9526 2068 29562922
Reflexes abnormal 18.20 15.42 6 9531 330 29564660
Bradyarrhythmia 18.13 15.42 10 9527 1975 29563015
Peripheral T-cell lymphoma unspecified recurrent 18.07 15.42 4 9533 46 29564944
Hypoglycaemic coma 17.33 15.42 10 9527 2153 29562837
Hypomania 17.28 15.42 10 9527 2165 29562825
Eosinophilic pneumonia 17.24 15.42 11 9526 2835 29562155
Completed suicide 17.22 15.42 66 9471 90180 29474810
Shock haemorrhagic 16.87 15.42 18 9519 9533 29555457
Suicide attempt 16.54 15.42 35 9502 34075 29530915
Vertigo 16.33 15.42 27 9510 21834 29543156
Calcium ionised increased 15.92 15.42 3 9534 14 29564976
Atrial tachycardia 15.62 15.42 9 9528 1932 29563058
Ventricular dyssynchrony 15.59 15.42 3 9534 16 29564974

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Electrocardiogram QRS complex prolonged 649.02 13.55 202 21076 9042 64468412
Bradycardia 365.05 13.55 306 20972 117913 64359541
Ventricular tachycardia 265.25 13.55 156 21122 34109 64443345
Atrial fibrillation 240.72 13.55 289 20989 170800 64306654
Electrocardiogram QT prolonged 237.45 13.55 202 21076 79246 64398208
Atrial flutter 178.84 13.55 99 21179 19281 64458173
Brugada syndrome 178.08 13.55 46 21232 1032 64476422
Toxicity to various agents 170.55 13.55 372 20906 363141 64114313
Cardiac arrest 168.81 13.55 230 21048 153834 64323620
Drug interaction 166.98 13.55 368 20910 361715 64115739
Arrhythmia 146.70 13.55 129 21149 52815 64424639
Atrioventricular block first degree 133.63 13.55 67 21211 10667 64466787
Bundle branch block right 113.05 13.55 59 21219 10210 64467244
Ventricular fibrillation 111.18 13.55 79 21199 23781 64453673
Tachyarrhythmia 100.54 13.55 46 21232 5980 64471474
Torsade de pointes 96.27 13.55 64 21214 17299 64460155
Hypotension 91.84 13.55 305 20973 380669 64096785
Syncope 90.94 13.55 176 21102 157459 64319995
Device pacing issue 90.62 13.55 17 21261 75 64477379
Device capturing issue 75.68 13.55 13 21265 30 64477424
Electrocardiogram abnormal 75.48 13.55 50 21228 13431 64464023
Tachycardia 74.33 13.55 157 21121 149422 64328032
Cardiogenic shock 72.27 13.55 70 21208 32357 64445097
Overdose 65.28 13.55 155 21123 159411 64318043
Sinus bradycardia 63.80 13.55 56 21222 22837 64454617
Intentional overdose 62.64 13.55 109 21169 89835 64387619
Ventricular dyssynchrony 59.70 13.55 11 21267 43 64477411
Atrioventricular block 58.79 13.55 41 21237 11974 64465480
Hyponatraemia 53.16 13.55 137 21141 148202 64329252
Completed suicide 52.44 13.55 178 21100 224236 64253218
Bradyarrhythmia 51.35 13.55 25 21253 3733 64473721
Bundle branch block left 50.88 13.55 35 21243 9999 64467455
Electrocardiogram PR prolongation 48.56 13.55 18 21260 1369 64476085
Palpitations 45.43 13.55 104 21174 104384 64373070
Stress cardiomyopathy 43.92 13.55 31 21247 9226 64468228
Defect conduction intraventricular 43.51 13.55 12 21266 348 64477106
Thalamic infarction 41.04 13.55 15 21263 1097 64476357
Pain 37.67 13.55 79 21199 553432 63924022
Accidental overdose 33.52 13.55 48 21230 33509 64443945
Pulseless electrical activity 33.18 13.55 30 21248 12709 64464745
Sinoatrial block 33.15 13.55 13 21265 1153 64476301
Drug level increased 32.82 13.55 48 21230 34148 64443306
Cerebral venous thrombosis 32.64 13.55 16 21262 2425 64475029
Cardio-respiratory arrest 32.30 13.55 88 21190 98305 64379149
Atrioventricular block complete 31.88 13.55 31 21247 14387 64463067
Rheumatoid arthritis 30.95 13.55 8 21270 164286 64313168
Ventricular extrasystoles 30.27 13.55 33 21245 17496 64459958
Bifascicular block 30.10 13.55 9 21269 350 64477104
Cardiac flutter 29.59 13.55 18 21260 4171 64473283
Acute kidney injury 29.17 13.55 250 21028 448990 64028464
Ventricular arrhythmia 28.78 13.55 22 21256 7393 64470061
Rectal polyp 28.55 13.55 12 21266 1272 64476182
Medication error 27.79 13.55 55 21223 49911 64427543
High frequency ablation 27.56 13.55 8 21270 280 64477174
Cutaneous T-cell lymphoma 27.28 13.55 14 21264 2338 64475116
Bundle branch block 27.23 13.55 12 21266 1428 64476026
Atrial tachycardia 26.97 13.55 16 21262 3543 64473911
Cardiac failure 26.60 13.55 100 21178 132273 64345181
Tubulointerstitial nephritis 26.27 13.55 41 21237 30868 64446586
International normalised ratio increased 26.17 13.55 71 21207 79096 64398358
Electrocardiogram QRS complex shortened 24.97 13.55 9 21269 632 64476822
Pericardial haemorrhage 24.76 13.55 16 21262 4120 64473334
Injection site discomfort 24.39 13.55 16 21262 4225 64473229
Drug intolerance 24.39 13.55 16 21262 187976 64289478
Conduction disorder 24.23 13.55 14 21264 2954 64474500
Infusion related reaction 24.19 13.55 12 21266 164455 64312999
Interstitial lung disease 24.09 13.55 79 21199 97653 64379801
Amaurosis 24.03 13.55 10 21268 1034 64476420
Drug level above therapeutic 23.60 13.55 19 21259 6882 64470572
Subdural haematoma 23.55 13.55 37 21241 28017 64449437
Cardiotoxicity 22.55 13.55 22 21256 10252 64467202
Electrocardiogram QRS complex abnormal 22.42 13.55 8 21270 546 64476908
Sensitisation 22.11 13.55 11 21267 1720 64475734
Cardiac ablation 21.87 13.55 11 21267 1761 64475693
Device malfunction 21.83 13.55 28 21250 17605 64459849
Suicide attempt 21.81 13.55 62 21216 70945 64406509
Musculoskeletal stiffness 21.36 13.55 7 21271 123199 64354255
Change of bowel habit 21.24 13.55 12 21266 2426 64475028
Arthralgia 21.11 13.55 75 21203 442185 64035269
Therapeutic product effect decreased 21.00 13.55 6 21272 115345 64362109
Hyperkalaemia 20.81 13.55 77 21201 101052 64376402
Loss of consciousness 20.45 13.55 100 21178 148265 64329189
Swelling 20.29 13.55 14 21264 160204 64317250
Slow response to stimuli 20.16 13.55 10 21268 1555 64475899
Sinus node dysfunction 19.62 13.55 17 21261 6811 64470643
Hypoglycaemic coma 19.55 13.55 14 21264 4260 64473194
Asthma 19.19 13.55 4 21274 95221 64382233
Pacemaker syndrome 18.97 13.55 3 21275 3 64477451
Membrane stabilising effect 18.97 13.55 3 21275 3 64477451
Cardiac tamponade 18.89 13.55 18 21260 8146 64469308
Microcytic anaemia 18.53 13.55 14 21264 4624 64472830
Unresponsive to stimuli 18.49 13.55 47 21231 50346 64427108
Thyroid disorder 18.45 13.55 21 21257 11671 64465783
Cardioversion 18.40 13.55 10 21268 1875 64475579
Dizziness 18.07 13.55 219 21059 429944 64047510
Extrasystoles 17.97 13.55 16 21262 6642 64470812
Nasopharyngitis 17.94 13.55 23 21255 196050 64281404
Peripheral T-cell lymphoma unspecified recurrent 17.90 13.55 4 21274 47 64477407
Subarachnoid haemorrhage 17.86 13.55 26 21252 18412 64459042
Electrocardiogram T wave inversion 17.86 13.55 14 21264 4880 64472574
Therapeutic product effect incomplete 17.73 13.55 6 21272 103476 64373978
Ischaemic stroke 17.41 13.55 33 21245 29002 64448452
Contraindicated product administered 17.21 13.55 7 21271 107822 64369632
Rectal haemorrhage 17.09 13.55 52 21226 61765 64415689
Cerebral haematoma 16.93 13.55 16 21262 7169 64470285
Haematoma 16.83 13.55 43 21235 46207 64431247
Unmasking of previously unidentified disease 16.81 13.55 9 21269 1638 64475816
Weight increased 16.62 13.55 28 21250 213320 64264134
Mixed liver injury 16.47 13.55 14 21264 5467 64471987
Intestinal haemorrhage 16.39 13.55 14 21264 5500 64471954
Reflexes abnormal 16.13 13.55 7 21271 803 64476651
Intracranial haematoma 16.10 13.55 7 21271 806 64476648
Acute respiratory distress syndrome 16.08 13.55 38 21240 38897 64438557
Diarrhoea 15.98 13.55 157 21121 722547 63754907
Drug-device interaction 15.82 13.55 4 21274 82 64477372
Dermatitis exfoliative generalised 15.54 13.55 14 21264 5902 64471552
Atrial conduction time prolongation 15.37 13.55 3 21275 17 64477437
Needle issue 15.22 13.55 17 21261 9255 64468199
Hypertensive crisis 15.22 13.55 24 21254 18224 64459230
Coma 15.02 13.55 63 21215 87552 64389902
Supraventricular tachycardia 14.59 13.55 24 21254 18883 64458571
Insomnia 14.47 13.55 27 21251 197809 64279645
Haemodynamic instability 14.40 13.55 21 21257 14891 64462563
Joint swelling 14.38 13.55 31 21247 215351 64262103
Pneumonia 14.36 13.55 117 21161 559459 63917995
Splenic rupture 14.32 13.55 9 21269 2210 64475244
Vomiting 14.24 13.55 115 21163 551002 63926452
Cerebral haemorrhage 14.14 13.55 43 21235 51047 64426407
Phospholipidosis 14.13 13.55 4 21274 128 64477326
Lung disorder 14.01 13.55 48 21230 60652 64416802
Electrocardiogram QT interval 13.67 13.55 4 21274 144 64477310

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01BC04 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class Ic
FDA EPC N0000175426 Antiarrhythmic
CHEBI has role CHEBI:38070 antiarrhythmic agent
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D061567 Voltage-Gated Sodium Channel Blockers

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atrial fibrillation indication 49436004 DOID:0060224
Paroxysmal atrial fibrillation indication 282825002
Paroxysmal atrial flutter indication 427665004
Prevention of Paroxysmal Supraventricular Tachycardia indication
Life-Threatening Ventricular Tachycardia indication
Cardioversion of Atrial Fibrillation off-label use
Hyperkalemia contraindication 14140009
Myocardial infarction contraindication 22298006 DOID:5844
Complete atrioventricular block contraindication 27885002
Sick sinus syndrome contraindication 36083008 DOID:13884
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cardiogenic shock contraindication 89138009
Kidney disease contraindication 90708001 DOID:557
Second degree atrioventricular block contraindication 195042002
Disease of liver contraindication 235856003 DOID:409
Smokes tobacco daily contraindication 449868002
Right Bundle Branch Block with Left Hemiblock contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.78 acidic
pKa2 8.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 5.19 CHEMBL CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.41 CHEMBL
Sodium channel protein type 4 subunit alpha Ion channel Ki 4.75 WOMBAT-PK
Potassium voltage-gated channel subfamily A member 5 Ion channel BLOCKER Kd 4 IUPHAR
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 2.77 WOMBAT-PK
Potassium voltage-gated channel subfamily A member 7 Ion channel BLOCKER Kd 5.10 IUPHAR
Potassium voltage-gated channel subfamily D member 2 Ion channel IC50 5 CHEMBL
Potassium voltage-gated channel subfamily C member 1 Ion channel BLOCKER IC50 4 IUPHAR

External reference:

IDSource
D00638 KEGG_DRUG
54143-56-5 SECONDARY_CAS_RN
4018822 VANDF
4019757 VANDF
C0016229 UMLSCUI
CHEBI:75984 CHEBI
K4D PDB_CHEM_ID
CHEMBL652 ChEMBL_ID
CHEMBL398673 ChEMBL_ID
CHEMBL1200822 ChEMBL_ID
D005424 MESH_DESCRIPTOR_UI
DB01195 DRUGBANK_ID
3356 PUBCHEM_CID
2560 IUPHAR_LIGAND_ID
4096 INN_ID
K94FTS1806 UNII
152403 RXNORM
2279 MMSL
43018 MMSL
4730 MMSL
d00234 MMSL
000628 NDDF
004483 NDDF
372751001 SNOMEDCT_US
46576005 SNOMEDCT_US
8886003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0010 TABLET 50 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0011 TABLET 100 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0012 TABLET 150 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50090-1132 TABLET 50 mg ORAL ANDA 18 sections
Flecainide Acetate Human Prescription Drug Label 1 50090-2233 TABLET 100 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2968 TABLET 100 mg ORAL ANDA 19 sections
Flecainide Acetate Human Prescription Drug Label 1 50090-5267 TABLET 100 mg ORAL ANDA 18 sections
Flecainide Acetate Human Prescription Drug Label 1 50090-5306 TABLET 50 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50268-320 TABLET 50 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50268-321 TABLET 100 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50268-322 TABLET 150 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 51407-018 TABLET 50 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 51407-019 TABLET 100 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 51407-020 TABLET 150 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 53746-641 TABLET 50 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 53746-642 TABLET 100 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 53746-643 TABLET 150 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 54868-5074 TABLET 50 mg ORAL ANDA 17 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 54868-5405 TABLET 100 mg ORAL ANDA 17 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 54868-5586 TABLET 150 mg ORAL ANDA 17 sections
Flecainide Acetate Human Prescription Drug Label 1 57237-063 TABLET 50 mg ORAL ANDA 18 sections
Flecainide Acetate Human Prescription Drug Label 1 57237-064 TABLET 100 mg ORAL ANDA 18 sections
Flecainide Acetate Human Prescription Drug Label 1 57237-065 TABLET 150 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 62559-380 TABLET 50 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 62559-381 TABLET 100 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 62559-382 TABLET 150 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 63304-794 TABLET 50 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 63304-795 TABLET 100 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 63304-796 TABLET 150 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 63629-1945 TABLET 100 mg ORAL ANDA 19 sections