flecainide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
Class I antiarrhythmics, procainamide and lidocaine derivatives 1176 54143-55-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tambocor
  • flecainide
  • flecaine
  • flecainide acetate
A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
  • Molecular weight: 414.35
  • Formula: C17H20F6N2O3
  • CLOGP: 4.15
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 59.59
  • ALOGS: -4.11
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 12.07 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
S (Water solubility) 48.40 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 43 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 95 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 6.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.52 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,BRAF,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MET,NTRK2,PDK2,PDK4,PRKDC 13
kinase-selectivity-class AXL 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 10.116 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 1
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
rat-kpuu-brain Rat brain Kpuu 0.051 % High 1

Approvals:

DateAgencyCompanyOrphan
Oct. 31, 1985 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Electrocardiogram QRS complex prolonged 902.41 14.63 231 21119 7117 90599980
Toxicity to various agents 394.72 14.63 408 20942 287438 90319659
Electrocardiogram QT prolonged 381.11 14.63 228 21122 72228 90534869
Bradycardia 345.57 14.63 226 21124 83621 90523476
Atrial fibrillation 300.66 14.63 250 21100 133361 90473736
Drug interaction 300.53 14.63 347 21003 276106 90330991
Ventricular tachycardia 292.49 14.63 134 21216 24574 90582523
Cardiac arrest 247.79 14.63 202 21148 104733 90502364
Arrhythmia 206.43 14.63 127 21223 42205 90564892
Atrial flutter 181.72 14.63 75 21275 10683 90596414
Torsade de pointes 169.22 14.63 79 21271 15103 90591994
Bundle branch block right 156.75 14.63 56 21294 5397 90601700
Atrioventricular block first degree 135.88 14.63 57 21293 8454 90598643
Cardiogenic shock 128.48 14.63 77 21273 24391 90582706
Syncope 123.21 14.63 154 21196 132509 90474588
Defect conduction intraventricular 121.69 14.63 24 21326 212 90606885
Device pacing issue 119.88 14.63 21 21329 88 90607009
Hypotension 117.00 14.63 245 21105 325152 90281945
Acute kidney injury 93.49 14.63 222 21128 320165 90286932
Hyponatraemia 93.35 14.63 135 21215 133403 90473694
Ventricular fibrillation 89.14 14.63 50 21300 13994 90593103
Completed suicide 84.88 14.63 135 21215 144923 90462174
Sinus bradycardia 80.41 14.63 50 21300 16902 90590195
Bundle branch block left 78.59 14.63 38 21312 7847 90599250
Change of bowel habit 71.53 14.63 25 21325 2258 90604839
Tachycardia 71.46 14.63 131 21219 157542 90449555
Rectal polyp 71.32 14.63 21 21329 1092 90606005
Brugada syndrome 68.52 14.63 17 21333 458 90606639
Cardio-respiratory arrest 67.89 14.63 79 21271 63061 90544036
Device capturing issue 66.43 14.63 11 21339 30 90607067
Ventricular dyssynchrony 65.65 14.63 12 21338 67 90607030
Infusion related reaction 65.52 14.63 10 21340 416770 90190327
Injection site discomfort 63.38 14.63 30 21320 5910 90601187
Cardiac failure 62.79 14.63 101 21249 109395 90497702
Bradyarrhythmia 62.25 14.63 23 21327 2438 90604659
Wound 58.98 14.63 3 21347 302977 90304120
Intentional overdose 58.57 14.63 90 21260 93744 90513353
Intestinal haemorrhage 58.56 14.63 26 21324 4421 90602676
Systemic lupus erythematosus 58.47 14.63 8 21342 361888 90245209
Conduction disorder 58.23 14.63 20 21330 1715 90605382
Atrioventricular block 57.62 14.63 32 21318 8783 90598314
Sensitisation 56.88 14.63 25 21325 4150 90602947
Tachyarrhythmia 56.75 14.63 27 21323 5379 90601718
Sinoatrial block 55.90 14.63 17 21333 988 90606109
Drug intolerance 55.80 14.63 18 21332 447573 90159524
Stress cardiomyopathy 54.92 14.63 36 21314 13319 90593778
Ventricular tachyarrhythmia 53.89 14.63 12 21338 199 90606898
Palpitations 53.80 14.63 107 21243 136621 90470476
Therapeutic product effect decreased 53.24 14.63 3 21347 277568 90329529
Electrocardiogram abnormal 52.99 14.63 32 21318 10266 90596831
Thalamic infarction 52.68 14.63 14 21336 498 90606599
Frustration tolerance decreased 52.53 14.63 29 21321 7867 90599230
Contraindicated product administered 51.89 14.63 7 21343 320132 90286965
Sinus node dysfunction 50.69 14.63 25 21325 5387 90601710
Swelling 50.24 14.63 18 21332 419040 90188057
Duodenal ulcer 49.97 14.63 30 21320 9522 90597575
Electrocardiogram PR prolongation 49.61 14.63 15 21335 855 90606242
Urine odour abnormal 49.28 14.63 27 21323 7217 90599880
Pericarditis 48.66 14.63 4 21346 270147 90336950
Rheumatoid arthritis 48.07 14.63 13 21337 362601 90244496
Overdose 47.77 14.63 111 21239 157598 90449499
Atrial conduction time prolongation 47.26 14.63 8 21342 26 90607071
Needle issue 46.46 14.63 33 21317 13901 90593196
Hepatic enzyme increased 45.85 14.63 14 21336 360722 90246375
Polyp 45.23 14.63 26 21324 7618 90599479
Musculoskeletal stiffness 44.61 14.63 8 21342 296524 90310573
Cerebral haemorrhage 43.62 14.63 47 21303 34475 90572622
Furuncle 42.83 14.63 25 21325 7536 90599561
Urine abnormality 42.30 14.63 25 21325 7712 90599385
Bifascicular block 42.11 14.63 9 21341 122 90606975
Arthropathy 41.78 14.63 17 21333 366225 90240872
Proctalgia 40.96 14.63 25 21325 8173 90598924
Pain 40.96 14.63 111 21239 996230 89610867
Ventricular arrhythmia 40.59 14.63 20 21330 4301 90602796
Cholestasis 39.98 14.63 46 21304 36253 90570844
Nodal arrhythmia 39.79 14.63 14 21336 1289 90605808
Thyroid disorder 39.32 14.63 33 21317 17752 90589345
Ventricular extrasystoles 38.78 14.63 29 21321 13221 90593876
Heart rate decreased 38.68 14.63 55 21295 53450 90553647
BRASH syndrome 38.29 14.63 15 21335 1864 90605233
Blister 38.09 14.63 7 21343 254991 90352106
Bladder disorder 37.05 14.63 26 21324 10746 90596351
Cutaneous T-cell lymphoma 36.82 14.63 14 21336 1606 90605491
Cerebral venous thrombosis 35.19 14.63 15 21335 2313 90604784
Mobility decreased 35.14 14.63 8 21342 250726 90356371
Lower respiratory tract infection 35.12 14.63 8 21342 250651 90356446
Irritable bowel syndrome 34.91 14.63 4 21346 207444 90399653
Accidental overdose 34.86 14.63 38 21312 28235 90578862
Hypersensitivity 34.22 14.63 34 21316 454643 90152454
Full blood count decreased 33.33 14.63 38 21312 29651 90577446
Peripheral coldness 33.26 14.63 27 21323 13865 90593232
Tubulointerstitial nephritis 32.89 14.63 35 21315 25308 90581789
Fibromyalgia 32.27 14.63 5 21345 206264 90400833
Hepatic cytolysis 32.08 14.63 38 21312 30878 90576219
Weight increased 31.74 14.63 31 21319 417896 90189201
Subdural haematoma 30.98 14.63 28 21322 16617 90590480
Stomatitis 30.91 14.63 13 21337 274685 90332412
Anticoagulation drug level abnormal 30.74 14.63 7 21343 129 90606968
Ill-defined disorder 30.04 14.63 4 21346 184887 90422210
Impaired healing 29.90 14.63 9 21341 234190 90372907
Alopecia 29.86 14.63 44 21306 495027 90112070
Postoperative wound infection 29.86 14.63 25 21325 13401 90593696
Pulseless electrical activity 29.43 14.63 21 21329 8911 90598186
Metabolic acidosis 28.73 14.63 49 21301 55627 90551470
Gallbladder disorder 28.67 14.63 29 21321 19774 90587323
Mass 28.59 14.63 26 21324 15551 90591546
Haemodynamic instability 28.50 14.63 23 21327 11716 90595381
Blood glucose decreased 28.03 14.63 31 21319 23398 90583699
Dermatitis exfoliative generalised 27.80 14.63 17 21333 5576 90601521
Rhythm idioventricular 27.65 14.63 8 21342 391 90606706
Hypertensive crisis 27.51 14.63 27 21323 17757 90589340
Type 2 diabetes mellitus 27.46 14.63 7 21343 203237 90403860
Device malfunction 27.27 14.63 29 21321 20948 90586149
Psoriatic arthropathy 27.01 14.63 10 21340 228325 90378772
Fall 26.98 14.63 200 21150 481610 90125487
Hyperkalaemia 26.94 14.63 52 21298 64912 90542185
Respiratory arrest 26.71 14.63 36 21314 33275 90573822
Drug-device interaction 26.23 14.63 6 21344 113 90606984
Heart rate irregular 25.46 14.63 30 21320 24238 90582859
Drug level above therapeutic 24.72 14.63 16 21334 5793 90601304
Bundle branch block 24.58 14.63 9 21341 930 90606167
Injection site mass 24.33 14.63 28 21322 22062 90585035
Musculoskeletal discomfort 23.79 14.63 27 21323 20964 90586133
Supraventricular tachycardia 23.79 14.63 24 21326 16312 90590785
Dizziness 23.64 14.63 227 21123 589057 90018040
Intracranial haematoma 23.25 14.63 7 21343 393 90606704
Tachycardia foetal 23.22 14.63 6 21344 191 90606906
Electrocardiogram QT interval 23.10 14.63 6 21344 195 90606902
C-reactive protein increased 23.10 14.63 7 21343 181382 90425715
Unresponsive to stimuli 22.98 14.63 36 21314 38085 90569012
Shock 22.92 14.63 31 21319 28747 90578350
Jaundice 22.87 14.63 33 21317 32484 90574613
Wheezing 22.70 14.63 14 21336 238066 90369031
Cardiac ablation 22.56 14.63 10 21340 1694 90605403
Hypokalaemia 22.47 14.63 75 21275 131041 90476056
Discomfort 22.42 14.63 19 21331 274316 90332781
Drug level increased 22.25 14.63 30 21320 27732 90579365
Sinusitis 22.16 14.63 29 21321 343059 90264038
Urinary incontinence 21.99 14.63 35 21315 37531 90569566
Pulmonary alveolar haemorrhage 21.85 14.63 15 21335 5983 90601114
Pericardial haemorrhage 21.64 14.63 10 21340 1866 90605231
Spinal epidural haematoma 21.51 14.63 9 21341 1325 90605772
Arthralgia 21.13 14.63 103 21247 778419 89828678
Cardiotoxicity 20.88 14.63 19 21331 11370 90595727
Lung neoplasm malignant 20.64 14.63 27 21323 24246 90582851
Presyncope 20.53 14.63 31 21319 31774 90575323
Extrasystoles 20.26 14.63 14 21336 5643 90601454
Subarachnoid haemorrhage 20.24 14.63 23 21327 17881 90589216
Cardiac failure acute 20.13 14.63 19 21331 11910 90595187
Bone disorder 20.10 14.63 26 21324 23094 90584003
Pacemaker syndrome 19.98 14.63 3 21347 3 90607094
Gait inability 19.86 14.63 5 21345 146451 90460646
Diffuse alveolar damage 19.74 14.63 8 21342 1087 90606010
Slow response to stimuli 19.73 14.63 8 21342 1088 90606009
Rash 19.54 14.63 109 21241 795991 89811106
Liver injury 19.29 14.63 8 21342 170559 90436538
Joint swelling 19.18 14.63 58 21292 503242 90103855
Dry mouth 18.72 14.63 10 21340 184049 90423048
Cerebral haematoma 18.71 14.63 12 21338 4277 90602820
Urticaria 18.63 14.63 28 21322 312706 90294391
Nasopharyngitis 18.48 14.63 43 21307 407061 90200036
Cardiac disorder 18.27 14.63 41 21309 56831 90550266
Renal failure 18.23 14.63 70 21280 130937 90476160
Adverse event 18.01 14.63 3 21347 117415 90489682
Rash pustular 17.92 14.63 15 21335 8034 90599063
Intentional product use issue 17.74 14.63 15 21335 216877 90390220
Therapeutic product effect incomplete 17.66 14.63 12 21338 193884 90413213
Coma 17.62 14.63 47 21303 72585 90534512
Atrioventricular block complete 17.27 14.63 16 21334 9795 90597302
Cutaneous vasculitis 17.26 14.63 14 21336 7179 90599918
Accelerated idioventricular rhythm 16.89 14.63 4 21346 88 90607009
Alkalosis 16.79 14.63 6 21344 578 90606519
Osteoarthritis 16.68 14.63 13 21337 195717 90411380
Haematemesis 16.50 14.63 29 21321 33697 90573400
International normalised ratio increased 16.21 14.63 35 21315 47281 90559816
Insomnia 16.13 14.63 34 21316 333440 90273657
Foetal death 16.01 14.63 22 21328 20701 90586396
Depression 15.97 14.63 29 21321 300572 90306525
Haemorrhage 15.94 14.63 44 21306 69325 90537772
Cardiac tamponade 15.76 14.63 12 21338 5620 90601477
Hepatocellular injury 15.62 14.63 26 21324 28932 90578165
Hallucination, visual 15.61 14.63 23 21327 23069 90584028
Gravitational oedema 15.59 14.63 7 21343 1222 90605875
Antisynthetase syndrome 15.55 14.63 4 21346 125 90606972
Hyperammonaemic encephalopathy 15.49 14.63 9 21341 2690 90604407
Product administered to patient of inappropriate age 15.47 14.63 11 21339 4642 90602455
Infection 15.06 14.63 40 21310 362054 90245043
Cardioactive drug level above therapeutic 14.95 14.63 4 21346 146 90606951
Ischaemic stroke 14.87 14.63 22 21328 22144 90584953
Cardioversion 14.86 14.63 7 21343 1363 90605734
Feeling abnormal 14.71 14.63 78 21272 167157 90439940
Asthenia 14.69 14.63 191 21159 533560 90073537

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Electrocardiogram QRS complex prolonged 403.57 15.26 125 13469 5698 42602043
Bradycardia 220.92 15.26 197 13397 85287 42522454
Brugada syndrome 175.81 15.26 45 13549 1008 42606733
Ventricular tachycardia 168.03 15.26 110 13484 30050 42577691
Toxicity to various agents 149.51 15.26 264 13330 228872 42378869
Atrial flutter 126.61 15.26 75 13519 17176 42590565
Electrocardiogram QT prolonged 118.73 15.26 108 13486 47837 42559904
Atrial fibrillation 113.85 15.26 178 13416 139415 42468326
Atrioventricular block first degree 98.79 15.26 46 13548 6445 42601296
Bundle branch block right 91.97 15.26 47 13547 8059 42599682
Tachyarrhythmia 69.72 15.26 31 13563 3901 42603840
Sinus bradycardia 63.37 15.26 46 13548 14807 42592934
Hypotension 62.40 15.26 202 13392 257429 42350312
Electrocardiogram abnormal 58.89 15.26 38 13556 10107 42597634
Syncope 58.77 15.26 110 13484 99296 42508445
Cardiac arrest 58.55 15.26 116 13478 109204 42498537
Tachycardia 57.46 15.26 110 13484 100977 42506764
Drug interaction 51.33 15.26 194 13400 266805 42340936
Hydrops foetalis 48.54 15.26 16 13578 889 42606852
Atrioventricular block 46.14 15.26 32 13562 9583 42598158
Intentional overdose 45.17 15.26 68 13526 51388 42556353
Electrocardiogram QRS complex shortened 43.77 15.26 11 13583 228 42607513
Supraventricular tachycardia 43.12 15.26 34 13560 12374 42595367
Electrocardiogram PR prolongation 42.97 15.26 15 13579 993 42606748
Atrioventricular block complete 41.35 15.26 32 13562 11332 42596409
Gastric ischaemia 39.67 15.26 8 13586 57 42607684
Enzyme inhibition 37.62 15.26 8 13586 76 42607665
Overdose 37.53 15.26 95 13499 105169 42502572
Palmoplantar pustulosis 35.84 15.26 11 13583 484 42607257
Cardiac flutter 35.16 15.26 16 13578 2124 42605617
Cardiogenic shock 34.01 15.26 49 13545 35591 42572150
Shock haemorrhagic 33.31 15.26 33 13561 16209 42591532
Drug level increased 32.61 15.26 41 13553 26159 42581582
Splenic rupture 32.49 15.26 14 13580 1633 42606108
Arrhythmia 32.18 15.26 51 13543 40266 42567475
High frequency ablation 31.30 15.26 8 13586 178 42607563
Secondary hypogonadism 30.85 15.26 11 13583 775 42606966
Treatment failure 30.57 15.26 64 13530 62560 42545181
Interstitial lung disease 30.26 15.26 73 13521 78389 42529352
Inflammatory pain 30.17 15.26 10 13584 565 42607176
Ventricular fibrillation 29.60 15.26 42 13552 30081 42577660
Lymphostasis 29.44 15.26 5 13589 11 42607730
Endocarditis fibroplastica 28.33 15.26 5 13589 15 42607726
Completed suicide 28.27 15.26 81 13513 96384 42511357
Device capturing issue 28.20 15.26 4 13590 0 42607741
Ventricular arrhythmia 28.04 15.26 20 13574 6259 42601482
Device pacing issue 27.85 15.26 6 13588 61 42607680
Overflow diarrhoea 27.67 15.26 6 13588 63 42607678
Amaurosis 26.36 15.26 10 13584 839 42606902
Blood thyroid stimulating hormone increased 26.30 15.26 18 13576 5274 42602467
Accidental overdose 25.65 15.26 38 13556 28292 42579449
Microcytic anaemia 24.38 15.26 14 13580 3021 42604720
Electrocardiogram QRS complex abnormal 24.05 15.26 8 13586 457 42607284
Defect conduction intraventricular 23.79 15.26 8 13586 473 42607268
Product administered to patient of inappropriate age 23.20 15.26 16 13578 4745 42602996
Gastrointestinal ischaemia 22.81 15.26 7 13587 308 42607433
Extrasystoles 22.55 15.26 15 13579 4194 42603547
Ejection fraction decreased 22.00 15.26 31 13563 22056 42585685
Lentigo maligna 21.25 15.26 7 13587 388 42607353
Arrhythmia supraventricular 20.93 15.26 10 13584 1483 42606258
Pulseless electrical activity 20.84 15.26 19 13575 8418 42599323
Torsade de pointes 20.54 15.26 19 13575 8575 42599166
Pleurothotonus 19.73 15.26 9 13585 1202 42606539
Palpitations 19.29 15.26 47 13547 50750 42556991
Acute respiratory distress syndrome 18.61 15.26 34 13560 30074 42577667
Heart rate 18.54 15.26 4 13590 41 42607700
Peripheral T-cell lymphoma unspecified recurrent 18.12 15.26 4 13590 46 42607695
Bradyarrhythmia 17.98 15.26 11 13583 2664 42605077
Pneumonia 17.72 15.26 72 13522 422077 42185664
Tachycardia foetal 17.38 15.26 6 13588 384 42607357
Reflexes abnormal 17.35 15.26 6 13588 386 42607355
Suicide attempt 16.81 15.26 42 13552 46058 42561683
Bundle branch block left 16.81 15.26 15 13579 6461 42601280
Plantar fasciitis 16.59 15.26 11 13583 3059 42604682
Retinal vascular occlusion 16.21 15.26 5 13589 224 42607517
Foetal exposure during pregnancy 16.11 15.26 42 13552 47269 42560472
Hypomania 16.06 15.26 10 13584 2498 42605243
Pelvic pain 16.01 15.26 11 13583 3243 42604498
Ventricular dyssynchrony 15.62 15.26 3 13591 16 42607725
Calcium ionised increased 15.32 15.26 3 13591 18 42607723

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Electrocardiogram QRS complex prolonged 1136.53 13.70 325 30940 12696 110545338
Bradycardia 522.57 13.70 397 30868 155120 110402914
Toxicity to various agents 473.19 13.70 628 30637 479927 110078107
Ventricular tachycardia 454.58 13.70 240 31025 49769 110508265
Electrocardiogram QT prolonged 378.69 13.70 284 30981 108676 110449358
Atrial fibrillation 345.60 13.70 373 30892 229269 110328765
Atrial flutter 268.43 13.70 133 31132 24129 110533905
Drug interaction 263.57 13.70 491 30774 499692 110058342
Cardiac arrest 260.44 13.70 299 30966 196454 110361580
Brugada syndrome 239.12 13.70 61 31204 1527 110556507
Bundle branch block right 229.54 13.70 97 31168 12194 110545840
Atrioventricular block first degree 203.25 13.70 93 31172 14132 110543902
Arrhythmia 197.46 13.70 161 31104 69414 110488620
Syncope 180.78 13.70 253 31012 202283 110355751
Hypotension 160.83 13.70 414 30851 523435 110034599
Torsade de pointes 157.22 13.70 91 31174 22509 110535525
Sinus bradycardia 139.78 13.70 93 31172 29390 110528644
Cardiogenic shock 136.61 13.70 120 31145 57218 110500816
Tachycardia 127.18 13.70 229 31036 226416 110331618
Device pacing issue 125.75 13.70 24 31241 142 110557892
Tachyarrhythmia 121.13 13.70 55 31210 8206 110549828
Electrocardiogram abnormal 111.01 13.70 68 31197 18641 110539393
Completed suicide 105.51 13.70 220 31045 242161 110315873
Ventricular fibrillation 103.52 13.70 89 31176 41224 110516810
Intentional overdose 102.81 13.70 155 31110 132346 110425688
Defect conduction intraventricular 100.28 13.70 26 31239 695 110557339
Atrioventricular block 99.27 13.70 61 31204 16816 110541218
Bundle branch block left 92.58 13.70 53 31212 12835 110545199
Device capturing issue 92.14 13.70 15 31250 27 110558007
Overdose 87.83 13.70 200 31065 233594 110324440
Bradyarrhythmia 75.99 13.70 34 31231 4900 110553134
Hyponatraemia 71.76 13.70 177 31088 217476 110340558
Acute kidney injury 69.71 13.70 359 30906 635071 109922963
Ventricular dyssynchrony 66.99 13.70 13 31252 85 110557949
Change of bowel habit 64.98 13.70 26 31239 2843 110555191
Rectal polyp 64.74 13.70 22 31243 1518 110556516
Electrocardiogram PR prolongation 60.87 13.70 22 31243 1821 110556213
Palpitations 58.42 13.70 135 31130 159077 110398957
Infusion related reaction 57.68 13.70 18 31247 381144 110176890
Cardio-respiratory arrest 57.34 13.70 111 31154 115725 110442309
Atrioventricular block complete 55.94 13.70 46 31219 20036 110537998
Ventricular arrhythmia 55.63 13.70 35 31230 10052 110547982
Injection site discomfort 53.93 13.70 30 31235 6877 110551157
Drug level increased 53.92 13.70 67 31198 47652 110510382
Sensitisation 52.65 13.70 25 31240 4126 110553908
Accidental overdose 52.61 13.70 69 31196 51765 110506269
Sinus node dysfunction 51.42 13.70 32 31233 9015 110549019
Swelling 50.62 13.70 18 31247 351023 110207011
BRASH syndrome 49.00 13.70 23 31242 3700 110554334
Drug intolerance 48.94 13.70 27 31238 406485 110151549
Wound 48.42 13.70 5 31260 234432 110323602
Glossodynia 47.81 13.70 4 31261 222000 110336034
Electrocardiogram QRS complex shortened 47.78 13.70 15 31250 805 110557229
Rheumatoid arthritis 47.42 13.70 13 31252 299600 110258434
Intestinal haemorrhage 46.94 13.70 28 31237 7313 110550721
Nodal arrhythmia 46.73 13.70 19 31246 2165 110555869
Sinoatrial block 46.57 13.70 17 31248 1448 110556586
Musculoskeletal stiffness 46.48 13.70 11 31254 279811 110278223
Cardiac failure 46.15 13.70 137 31128 187489 110370545
Pulseless electrical activity 45.88 13.70 38 31227 16719 110541315
Thyroid disorder 45.46 13.70 38 31227 16931 110541103
Stress cardiomyopathy 43.60 13.70 36 31229 15770 110542264
Duodenal ulcer 42.81 13.70 39 31226 19475 110538559
Frustration tolerance decreased 42.48 13.70 28 31237 8703 110549331
Systemic lupus erythematosus 42.24 13.70 10 31255 254328 110303706
Mobility decreased 42.16 13.70 8 31257 237414 110320620
Therapeutic product effect decreased 41.79 13.70 9 31256 244307 110313727
Urine odour abnormal 41.57 13.70 26 31239 7389 110550645
Ventricular extrasystoles 41.56 13.70 41 31224 22600 110535434
Conduction disorder 41.22 13.70 21 31244 4034 110554000
Gastric ischaemia 40.63 13.70 8 31257 57 110557977
Hepatic enzyme increased 40.56 13.70 20 31245 320872 110237162
Pain 40.33 13.70 137 31128 954818 109603216
Atrial conduction time prolongation 39.49 13.70 8 31257 67 110557967
Bifascicular block 39.36 13.70 11 31254 393 110557641
Hyperkalaemia 39.11 13.70 105 31160 135691 110422343
Extrasystoles 38.84 13.70 26 31239 8292 110549742
Lower respiratory tract infection 37.63 13.70 11 31254 243095 110314939
Suicide attempt 37.17 13.70 87 31178 103307 110454727
Anticoagulation drug level abnormal 37.15 13.70 10 31255 310 110557724
Fibromyalgia 37.01 13.70 3 31262 170906 110387128
Thalamic infarction 36.80 13.70 14 31251 1338 110556696
Cardiac ablation 36.63 13.70 17 31248 2665 110555369
Furuncle 35.52 13.70 25 31240 8643 110549391
Weight increased 35.25 13.70 40 31225 419604 110138430
Irritable bowel syndrome 35.24 13.70 3 31262 164212 110393822
Secondary hypogonadism 34.99 13.70 12 31253 851 110557183
Subdural haematoma 34.65 13.70 47 31218 36407 110521627
Polyp 34.57 13.70 26 31239 9954 110548080
Interstitial lung disease 34.50 13.70 102 31163 139232 110418802
Urine abnormality 34.44 13.70 25 31240 9071 110548963
Bladder disorder 34.18 13.70 27 31238 11110 110546924
Needle issue 34.04 13.70 33 31232 17807 110540227
Stomatitis 33.91 13.70 17 31248 270225 110287809
Enzyme inhibition 33.81 13.70 8 31257 145 110557889
Pericarditis 33.75 13.70 10 31255 219104 110338930
Cardiotoxicity 33.68 13.70 32 31233 16849 110541185
Heart rate decreased 33.50 13.70 73 31192 82683 110475351
Electrocardiogram QRS complex abnormal 32.20 13.70 11 31254 771 110557263
Blister 32.19 13.70 12 31253 227364 110330670
Contraindicated product administered 32.09 13.70 15 31250 248252 110309782
Nasopharyngitis 31.61 13.70 39 31226 394322 110163712
Hypersensitivity 31.30 13.70 41 31224 403957 110154077
Cerebral haemorrhage 30.62 13.70 61 31204 64907 110493127
Hypertensive crisis 30.43 13.70 36 31229 24336 110533698
Shock haemorrhagic 30.36 13.70 38 31227 27209 110530825
Proctalgia 30.13 13.70 27 31238 13195 110544839
International normalised ratio increased 30.09 13.70 72 31193 86700 110471334
Dizziness 29.84 13.70 315 30950 697878 109860156
Cholestasis 29.71 13.70 60 31205 64458 110493576
Palmoplantar pustulosis 29.71 13.70 11 31254 975 110557059
Cardiac flutter 29.32 13.70 19 31246 5738 110552296
Arthropathy 29.30 13.70 23 31242 287499 110270535
Loss of consciousness 28.88 13.70 121 31144 196185 110361849
Ill-defined disorder 28.46 13.70 5 31260 156848 110401186
Rhythm idioventricular 28.30 13.70 10 31255 775 110557259
Therapeutic product effect incomplete 28.19 13.70 14 31251 223791 110334243
Cerebral venous thrombosis 27.76 13.70 15 31250 3247 110554787
Ejection fraction decreased 27.75 13.70 45 31220 40835 110517199
Intentional product use issue 27.66 13.70 18 31247 247888 110310146
Peripheral coldness 27.59 13.70 30 31235 18510 110539524
Metabolic acidosis 27.59 13.70 76 31189 99668 110458366
Hepatic cytolysis 27.53 13.70 53 31212 55000 110503034
Alopecia 27.25 13.70 38 31227 364715 110193319
Cutaneous T-cell lymphoma 27.25 13.70 15 31250 3369 110554665
Electrocardiogram T wave inversion 27.11 13.70 18 31247 5662 110552372
Drug level above therapeutic 27.08 13.70 24 31241 11564 110546470
Endocarditis fibroplastica 26.91 13.70 5 31260 25 110558009
C-reactive protein increased 26.90 13.70 14 31251 217905 110340129
Impaired healing 26.82 13.70 11 31254 196706 110361328
High frequency ablation 26.80 13.70 8 31257 362 110557672
Cerebral haematoma 26.69 13.70 22 31243 9610 110548424
Wheezing 26.54 13.70 20 31245 255210 110302824
Bundle branch block 26.42 13.70 12 31253 1791 110556243
Bursitis 26.23 13.70 3 31262 129915 110428119
Gallbladder disorder 26.15 13.70 31 31234 20998 110537036
Haemodynamic instability 25.63 13.70 32 31233 22856 110535178
Supraventricular tachycardia 25.54 13.70 33 31232 24389 110533645
Atrial tachycardia 25.51 13.70 21 31244 9157 110548877
Lymphostasis 25.47 13.70 5 31260 35 110557999
Splenic rupture 24.91 13.70 13 31252 2624 110555410
Diffuse alveolar damage 24.75 13.70 15 31250 4032 110554002
Dry mouth 24.45 13.70 13 31252 199935 110358099
Cardiac failure acute 24.35 13.70 32 31233 24046 110533988
Postoperative wound infection 24.34 13.70 26 31239 15727 110542307
Blood cholesterol increased 24.13 13.70 11 31254 184774 110373260
Full blood count decreased 24.09 13.70 37 31228 32062 110525972
Ventricular tachyarrhythmia 23.93 13.70 8 31257 525 110557509
Unmasking of previously unidentified disease 23.88 13.70 13 31252 2855 110555179
Spinal epidural haematoma 23.77 13.70 11 31254 1714 110556320
Pericardial haemorrhage 23.62 13.70 16 31249 5201 110552833
Microcytic anaemia 23.34 13.70 17 31248 6201 110551833
Unresponsive to stimuli 23.28 13.70 54 31211 63736 110494298
Urticaria 23.04 13.70 34 31231 318823 110239211
Cardiac disorder 22.98 13.70 60 31205 76220 110481814
Fall 22.89 13.70 266 30999 603216 109954818
Vertigo 22.85 13.70 65 31200 86805 110471229
Type 2 diabetes mellitus 22.45 13.70 11 31254 177221 110380813
Mental status changes 22.05 13.70 59 31206 76063 110481971
Obesity 21.95 13.70 3 31262 113348 110444686
Inflammatory pain 21.70 13.70 10 31255 1543 110556491
Amaurosis 21.48 13.70 10 31255 1579 110556455
Drug hypersensitivity 21.32 13.70 62 31203 454028 110104006
Overflow diarrhoea 21.29 13.70 6 31259 221 110557813
Depression 20.89 13.70 36 31229 317299 110240735
Cardioversion 20.66 13.70 11 31254 2312 110555722
Shock 20.26 13.70 46 31219 53542 110504492
Insomnia 20.20 13.70 45 31220 360545 110197489
Sinusitis 20.14 13.70 33 31232 296655 110261379
Arrhythmia supraventricular 20.13 13.70 11 31254 2435 110555599
Device malfunction 19.94 13.70 30 31235 25528 110532506
Gastrointestinal ischaemia 19.92 13.70 7 31258 534 110557500
Migraine 19.78 13.70 12 31253 171640 110386394
Mass 19.71 13.70 26 31239 19604 110538430
Drug-device interaction 19.64 13.70 5 31260 124 110557910
Pacemaker syndrome 19.44 13.70 3 31262 3 110558031
Membrane stabilising effect 19.44 13.70 3 31262 3 110558031
Hypokalaemia 19.17 13.70 102 31163 182346 110375688
Rash 19.01 13.70 145 31120 820819 109737215
Condition aggravated 18.85 13.70 126 31139 734710 109823324
Tubulointerstitial nephritis 18.77 13.70 45 31220 54239 110503795
Colitis microscopic 18.77 13.70 21 31244 13373 110544661
Asthma 18.76 13.70 26 31239 250265 110307769
Haematoma 18.66 13.70 47 31218 58429 110499605
Discomfort 18.52 13.70 20 31245 214687 110343347
Psoriatic arthropathy 18.50 13.70 17 31248 196744 110361290
Joint swelling 18.31 13.70 64 31201 442781 110115253
Haemorrhage 18.28 13.70 69 31196 106623 110451411
Hypoglycaemic coma 18.25 13.70 14 31251 5519 110552515
Bone disorder 18.16 13.70 26 31239 21166 110536868
Infection 18.08 13.70 48 31217 362152 110195882
Liver injury 18.07 13.70 10 31255 150403 110407631
Cardiac tamponade 18.07 13.70 19 31246 11288 110546746
Gait inability 17.99 13.70 8 31257 136368 110421666
Blood pressure systolic increased 17.97 13.70 58 31207 82933 110475101
Vomiting 17.87 13.70 168 31097 910507 109647527
Peripheral T-cell lymphoma unspecified recurrent 17.87 13.70 4 31261 56 110557978
Wound infection 17.66 13.70 3 31262 96462 110461572
Lactic acidosis 17.57 13.70 62 31203 92749 110465285
Pneumonia 17.52 13.70 161 31104 876553 109681481
Musculoskeletal discomfort 17.48 13.70 27 31238 23511 110534523
Ischaemic stroke 17.38 13.70 37 31228 41226 110516808
Alkalosis 17.20 13.70 7 31258 799 110557235
Sinus arrest 16.84 13.70 12 31253 4230 110553804
Coma 16.82 13.70 72 31193 117797 110440237
Blood glucose decreased 16.76 13.70 30 31235 29458 110528576
Dermatitis exfoliative generalised 16.76 13.70 18 31247 10954 110547080
Inflammation 16.67 13.70 18 31247 193220 110364814
Slow response to stimuli 16.52 13.70 9 31256 1979 110556055
Haematuria 16.19 13.70 56 31209 82949 110475085
Arthralgia 16.08 13.70 142 31123 779490 109778544
Potentiating drug interaction 15.88 13.70 18 31247 11625 110546409
Injection site reaction 15.81 13.70 3 31262 89067 110468967
Asthenia 15.79 13.70 278 30987 688721 109869313
Pruritus 15.78 13.70 98 31167 581462 109976572
Neovascular age-related macular degeneration 15.69 13.70 6 31259 581 110557453
Product administered to patient of inappropriate age 15.59 13.70 15 31250 8021 110550013
Medication error 15.53 13.70 65 31200 105301 110452733
Intracranial haematoma 15.52 13.70 7 31258 1027 110557007
Reflexes abnormal 15.44 13.70 7 31258 1040 110556994
Prescribed overdose 15.44 13.70 3 31262 87578 110470456
Subarachnoid haemorrhage 15.35 13.70 29 31236 29673 110528361
Product administration error 15.25 13.70 33 31232 37184 110520850
Acute respiratory distress syndrome 15.17 13.70 41 31224 53157 110504877
Lung neoplasm malignant 15.02 13.70 31 31234 33811 110524223
Plantar fasciitis 14.87 13.70 12 31253 5089 110552945
Lentigo maligna 14.82 13.70 6 31259 676 110557358
Injury 14.75 13.70 17 31248 177248 110380786
Respiratory arrest 14.73 13.70 43 31222 58256 110499778
Pleurothotonus 14.61 13.70 9 31256 2489 110555545
Neutrophil count decreased 14.58 13.70 8 31257 120933 110437101
Disease progression 14.03 13.70 30 31235 244004 110314030
Drug-disease interaction 14.01 13.70 8 31257 1928 110556106
Poisoning deliberate 13.97 13.70 26 31239 26305 110531729
Injection site mass 13.94 13.70 25 31240 24588 110533446

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01BC04 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class Ic
FDA EPC N0000175426 Antiarrhythmic
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D061567 Voltage-Gated Sodium Channel Blockers
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:38070 anti-arrhythmia drug

Related Drugs by ATC class:

C01BC Antiarrhythmics, class Ic 4 drugs
encainideethacizinelorcainidepropafenone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Atrial fibrillation indication 49436004 DOID:0060224
Paroxysmal atrial fibrillation indication 282825002
Paroxysmal atrial flutter indication 427665004
Prevention of Paroxysmal Supraventricular Tachycardia indication
Life-Threatening Ventricular Tachycardia indication
Cardioversion of Atrial Fibrillation off-label use
Hyperkalemia contraindication 14140009
Myocardial infarction contraindication 22298006 DOID:5844
Complete atrioventricular block contraindication 27885002
Sick sinus syndrome contraindication 36083008 DOID:13884
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cardiogenic shock contraindication 89138009
Kidney disease contraindication 90708001 DOID:557
Second degree atrioventricular block contraindication 195042002
Disease of liver contraindication 235856003 DOID:409
Smokes tobacco daily contraindication 449868002
Right Bundle Branch Block with Left Hemiblock contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.78 acidic
pKa2 8.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 5.19 CHEMBL CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.41 CHEMBL
Sodium channel protein type 4 subunit alpha Ion channel Ki 4.75 WOMBAT-PK
Potassium voltage-gated channel subfamily A member 5 Ion channel BLOCKER Kd 4 IUPHAR
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 2.77 WOMBAT-PK
Potassium voltage-gated channel subfamily A member 7 Ion channel BLOCKER Kd 5.10 IUPHAR
Potassium voltage-gated channel subfamily D member 2 Ion channel IC50 5 CHEMBL
Potassium voltage-gated channel subfamily C member 1 Ion channel BLOCKER IC50 4 IUPHAR

External reference:

IDSource
D00638 KEGG_DRUG
54143-56-5 SECONDARY_CAS_RN
4018822 VANDF
4019757 VANDF
C0016229 UMLSCUI
CHEBI:75984 CHEBI
K4D PDB_CHEM_ID
CHEMBL652 ChEMBL_ID
CHEMBL1200822 ChEMBL_ID
D005424 MESH_DESCRIPTOR_UI
DB01195 DRUGBANK_ID
3356 PUBCHEM_CID
2560 IUPHAR_LIGAND_ID
4096 INN_ID
K94FTS1806 UNII
152403 RXNORM
2279 MMSL
43018 MMSL
4730 MMSL
d00234 MMSL
000628 NDDF
004483 NDDF
372751001 SNOMEDCT_US
46576005 SNOMEDCT_US
8886003 SNOMEDCT_US
K94FTS1806 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0010 TABLET 50 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0011 TABLET 100 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0012 TABLET 150 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 42806-817 TABLET 50 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 42806-818 TABLET 100 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 42806-819 TABLET 150 mg ORAL ANDA 18 sections
Flecainide Acetate Human Prescription Drug Label 1 50090-2233 TABLET 100 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2968 TABLET 100 mg ORAL ANDA 19 sections
Flecainide Acetate Human Prescription Drug Label 1 50090-5306 TABLET 50 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50090-6035 TABLET 50 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50090-6810 TABLET 50 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50268-320 TABLET 50 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50268-321 TABLET 100 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50268-322 TABLET 150 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 51407-018 TABLET 50 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 51407-019 TABLET 100 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 51407-020 TABLET 150 mg ORAL ANDA 19 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 53746-641 TABLET 50 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 53746-642 TABLET 100 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 53746-643 TABLET 150 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 54868-5074 TABLET 50 mg ORAL ANDA 17 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 54868-5405 TABLET 100 mg ORAL ANDA 17 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 54868-5586 TABLET 150 mg ORAL ANDA 17 sections
Flecainide Acetate Human Prescription Drug Label 1 57237-063 TABLET 50 mg ORAL ANDA 18 sections
Flecainide Acetate Human Prescription Drug Label 1 57237-064 TABLET 100 mg ORAL ANDA 18 sections
Flecainide Acetate Human Prescription Drug Label 1 57237-065 TABLET 150 mg ORAL ANDA 18 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 62135-660 TABLET 50 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 62135-661 TABLET 100 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 62135-662 TABLET 150 mg ORAL ANDA 12 sections
Flecainide Acetate HUMAN PRESCRIPTION DRUG LABEL 1 62559-380 TABLET 50 mg ORAL ANDA 19 sections