alendronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 112 66376-36-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alendronate monosodium salt trihydrate
  • alendronate sodium trihydrate
  • alendronate sodium hydrate
  • alendronate
  • alendronic acid
  • alendronate sodium
  • aminohydroxybutane bisphosphonate
  • MK-217
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
  • Molecular weight: 249.10
  • Formula: C4H13NO7P2
  • CLOGP: -3.79
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 6
  • TPSA: 161.31
  • ALOGS: -1.17
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg O
10 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 45 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.68 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.33 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.22 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 1995 FDA MERCK AND CO INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 6978.14 10.64 3823 324106 33641 50243554
Low turnover osteopathy 3063.39 10.64 1103 326826 2891 50274304
Osteonecrosis 2784.87 10.64 1765 326164 20752 50256443
Osteonecrosis of jaw 2342.10 10.64 1831 326098 30695 50246500
Intramedullary rod insertion 2162.13 10.64 714 327215 1286 50275909
Pemphigus 1925.45 10.64 3068 324861 117098 50160097
Systemic lupus erythematosus 1684.74 10.64 3157 324772 137465 50139730
Glossodynia 1553.42 10.64 2728 325201 112841 50164354
Stress fracture 1526.96 10.64 790 327139 6085 50271110
Atypical femur fracture 1351.73 10.64 653 327276 4263 50272932
Osteoarthritis 1180 10.64 1811 326118 66795 50210400
Fracture nonunion 1158.75 10.64 462 327467 1742 50275453
Hand deformity 1098.70 10.64 2168 325761 98031 50179164
Arthropathy 1008.46 10.64 2762 325167 155144 50122051
Open reduction of fracture 1003.89 10.64 347 327582 768 50276427
Osteomyelitis 999.55 10.64 959 326970 21394 50255801
Abdominal discomfort 979.65 10.64 3511 324418 228130 50049065
Dental caries 977.97 10.64 674 327255 9193 50268002
Wound 950.74 10.64 2110 325819 103684 50173511
Anaemia postoperative 917.11 10.64 386 327543 1725 50275470
Hyperlipidaemia 893.14 10.64 808 327121 16682 50260513
Alopecia 864.47 10.64 3506 324423 241541 50035654
Toxicity to various agents 835.01 10.64 179 327750 212320 50064875
Tooth disorder 808.47 10.64 888 327041 23340 50253855
Impaired healing 806.01 10.64 1544 326385 68242 50208953
Death 736.70 10.64 617 327312 324762 49952433
Pericarditis 728.77 10.64 1589 326340 77100 50200095
Nausea 713.98 10.64 2279 325650 703119 49574076
Spinal osteoarthritis 686.27 10.64 634 327295 13458 50263737
Completed suicide 681.14 10.64 44 327885 131845 50145350
Diarrhoea 667.57 10.64 1801 326128 586675 49690520
Jaw disorder 667.52 10.64 410 327519 4533 50272662
Anti-cyclic citrullinated peptide antibody positive 665.70 10.64 1436 326493 69151 50208044
Oral infection 651.21 10.64 378 327551 3736 50273459
Discomfort 638.40 10.64 1842 326087 106538 50170657
Vomiting 610.04 10.64 1299 326630 459459 49817736
Gastrooesophageal reflux disease 603.21 10.64 1449 326480 74979 50202216
Vitamin D deficiency 594.41 10.64 533 327396 10869 50266326
Bone disorder 560.27 10.64 649 327280 18103 50259092
Osteopenia 559.51 10.64 619 327310 16399 50260796
Hypercholesterolaemia 549.57 10.64 516 327413 11187 50266008
Swelling 542.66 10.64 2656 325273 198216 50078979
Foot fracture 540.33 10.64 659 327270 19432 50257763
Intervertebral disc degeneration 522.88 10.64 535 327394 12926 50264269
Contraindicated product administered 520 10.64 2126 325803 146832 50130363
Off label use 504.61 10.64 1496 326433 472930 49804265
Tooth fracture 494.90 10.64 447 327482 9204 50267991
Bursitis 489.70 10.64 659 327270 21476 50255719
Temporomandibular joint syndrome 458.73 10.64 286 327643 3253 50273942
Fracture delayed union 458.30 10.64 245 327684 2031 50275164
Duodenal ulcer perforation 455.41 10.64 950 326979 44661 50232534
Exostosis of jaw 451.03 10.64 199 327730 1020 50276175
Product dose omission issue 450.51 10.64 321 327608 183517 50093678
Neutropenia 449.39 10.64 198 327731 147767 50129428
Device failure 447.64 10.64 334 327595 5194 50272001
Synovitis 427.48 10.64 1762 326167 122103 50155092
Helicobacter infection 421.05 10.64 969 326960 48733 50228462
Blood cholesterol increased 410.16 10.64 1023 326906 54192 50223003
Acute kidney injury 405.73 10.64 530 327399 227528 50049667
Gingival disorder 405.34 10.64 255 327674 2950 50274245
Pathological fracture 392.32 10.64 355 327574 7327 50269868
Febrile neutropenia 392.07 10.64 78 327851 97589 50179606
Drug interaction 378.04 10.64 442 327487 199179 50078016
Hip arthroplasty 375.58 10.64 693 327236 29736 50247459
Medical device removal 370.27 10.64 170 327759 972 50276223
Knee arthroplasty 367.66 10.64 755 327174 35091 50242104
Headache 364.48 10.64 1868 326061 504667 49772528
Intentional overdose 362.01 10.64 9 327920 62495 50214700
Periodontal disease 359.84 10.64 182 327747 1328 50275867
Infusion related reaction 357.34 10.64 2095 325834 167462 50109733
Adverse event 354.02 10.64 838 327091 42925 50234270
Scoliosis 349.87 10.64 311 327618 6265 50270930
Exostosis 349.23 10.64 404 327525 11249 50265946
Spondylolisthesis 338.72 10.64 226 327703 2911 50274284
Hypotension 332.76 10.64 638 327291 234831 50042364
Diverticulum 331.63 10.64 376 327553 10238 50266957
Maternal exposure during pregnancy 330.08 10.64 1964 325965 157814 50119381
Rheumatoid factor positive 329.33 10.64 884 327045 48975 50228220
Bone density decreased 323.61 10.64 379 327550 10696 50266499
Bone loss 321.49 10.64 206 327723 2466 50274729
Rib fracture 321.09 10.64 501 327428 18720 50258475
Internal fixation of fracture 317.78 10.64 130 327799 532 50276663
Calcium deficiency 316.13 10.64 144 327785 806 50276389
Tooth extraction 313.76 10.64 339 327590 8736 50268459
Fall 309.34 10.64 3423 324506 331509 49945686
Disease progression 309.28 10.64 117 327812 95749 50181446
Dyspnoea 308.83 10.64 2181 325748 545427 49731768
Osteoporosis 303.78 10.64 803 327126 44076 50233119
Drug abuse 300.04 10.64 23 327906 59823 50217372
Pyrexia 293.35 10.64 1367 326562 378836 49898359
Spinal compression fracture 290.96 10.64 384 327545 12272 50264923
Tooth loss 285.76 10.64 270 327659 5900 50271295
Malaise 284.55 10.64 1164 326765 334368 49942827
Hip fracture 283.58 10.64 561 327368 25370 50251825
Lumbar spinal stenosis 277.60 10.64 224 327705 3930 50273265
Rotator cuff syndrome 271.18 10.64 354 327575 11190 50266005
Injection site pain 269.00 10.64 196 327733 110828 50166367
Resorption bone increased 262.01 10.64 129 327800 882 50276313
Jaw fracture 261.17 10.64 175 327754 2271 50274924
Suicide attempt 253.46 10.64 22 327907 51710 50225485
Thrombocytopenia 247.71 10.64 277 327652 127396 50149799
Asthenia 246.56 10.64 1146 326783 317896 49959299
Malignant neoplasm progression 244.60 10.64 69 327860 68055 50209140
Periodontitis 243.08 10.64 183 327746 2886 50274309
Hepatic enzyme increased 240.93 10.64 1620 326309 135760 50141435
White blood cell count decreased 240.14 10.64 241 327688 116481 50160714
Kyphosis 239.78 10.64 162 327767 2133 50275062
Loose tooth 235.93 10.64 184 327745 3066 50274129
Large intestine polyp 234.62 10.64 263 327666 7069 50270126
Basal cell carcinoma 230.16 10.64 484 327445 22872 50254323
Muscle strain 228.10 10.64 255 327674 6833 50270362
Radius fracture 227.16 10.64 179 327750 3030 50274165
Cardiac arrest 226.71 10.64 130 327799 83521 50193674
Bone graft 224.12 10.64 109 327820 723 50276472
Blood loss anaemia 222.10 10.64 269 327660 7870 50269325
Tooth abscess 221.50 10.64 340 327589 12520 50264675
Abortion spontaneous 221.40 10.64 12 327917 41760 50235435
Blood parathyroid hormone decreased 220.52 10.64 251 327678 6863 50270332
Oral disorder 220.18 10.64 263 327666 7581 50269614
Pelvic fracture 216.15 10.64 317 327612 11203 50265992
Gingivitis 210.70 10.64 248 327681 7036 50270159
Fibrocystic breast disease 207.95 10.64 113 327816 971 50276224
Tonsillar disorder 207.33 10.64 111 327818 923 50276272
Granuloma skin 202.30 10.64 218 327711 5600 50271595
Product use issue 201.44 10.64 1656 326273 147819 50129376
Lumbar radiculopathy 198.73 10.64 130 327799 1616 50275579
Wrist fracture 198.27 10.64 304 327625 11183 50266012
Limb asymmetry 197.90 10.64 100 327829 728 50276467
Seizure 197.23 10.64 286 327643 117588 50159607
Hypertension 194.74 10.64 2159 325770 209044 50068151
Tibia fracture 194.32 10.64 189 327740 4286 50272909
Cerumen impaction 194.14 10.64 105 327824 893 50276302
Ulna fracture 193.22 10.64 106 327823 930 50276265
Edentulous 192.83 10.64 70 327859 189 50277006
Tonsillectomy 192.28 10.64 96 327833 679 50276516
Drug intolerance 192.19 10.64 2218 325711 216886 50060309
COVID-19 192.02 10.64 35 327894 46627 50230568
Oral cavity fistula 190.72 10.64 90 327839 553 50276642
Pneumonia 189.62 10.64 1556 326373 376845 49900350
Platelet count decreased 189.43 10.64 224 327705 100502 50176693
Panniculitis 187.79 10.64 253 327676 8250 50268945
Uterine disorder 185.58 10.64 147 327782 2508 50274687
Irritable bowel syndrome 184.53 10.64 741 327188 50700 50226495
Feeling abnormal 183.24 10.64 333 327596 125159 50152036
Cataract 183.18 10.64 698 327231 46602 50230593
Meniscus injury 183.01 10.64 215 327714 6087 50271108
Hyperhidrosis 175.63 10.64 192 327737 89234 50187961
Rheumatic fever 173.77 10.64 356 327573 16511 50260684
Type 2 diabetes mellitus 173.67 10.64 554 327375 33821 50243374
Hospitalisation 172.38 10.64 114 327815 67823 50209372
Fistula discharge 172.07 10.64 95 327834 845 50276350
Cardio-respiratory arrest 171.73 10.64 67 327862 53825 50223370
Sepsis 170.75 10.64 380 327549 132545 50144650
Hypothyroidism 169.70 10.64 547 327382 33578 50243617
Injection site erythema 167.95 10.64 143 327786 74793 50202402
Hiatus hernia 167.95 10.64 369 327560 17975 50259220
Dizziness 166.82 10.64 1439 326490 344930 49932265
Abdominal pain 166.49 10.64 876 327053 235352 50041843
Ligament sprain 164.29 10.64 266 327663 10259 50266936
Rheumatoid nodule 163.39 10.64 295 327634 12440 50264755
Fibula fracture 163.32 10.64 144 327785 2868 50274327
Stress urinary incontinence 163.25 10.64 123 327806 1942 50275253
Synovial cyst 162.39 10.64 231 327698 7935 50269260
Patellofemoral pain syndrome 161.86 10.64 77 327852 483 50276712
Swollen joint count increased 161.67 10.64 321 327608 14552 50262643
Pancytopenia 160.01 10.64 185 327744 83845 50193350
Cataract operation 158.92 10.64 163 327766 3948 50273247
Electrocardiogram QT prolonged 158.06 10.64 69 327860 51817 50225378
Atypical fracture 156.93 10.64 77 327852 522 50276673
Somnolence 155.98 10.64 500 327429 154485 50122710
Osteitis 155.46 10.64 140 327789 2870 50274325
Mitral valve prolapse 154.50 10.64 121 327808 2029 50275166
Haemorrhoids 152.03 10.64 363 327566 18690 50258505
Intentional product misuse 150.74 10.64 57 327872 46677 50230518
Periprosthetic fracture 149.75 10.64 67 327862 357 50276838
Wrong technique in product usage process 149.34 10.64 87 327842 55423 50221772
Flushing 148.82 10.64 129 327800 66886 50210309
Tendonitis 147.27 10.64 331 327598 16374 50260821
Fracture displacement 145.30 10.64 92 327837 1077 50276118
Muscle injury 144.80 10.64 549 327380 36562 50240633
Anaphylactic reaction 143.61 10.64 86 327843 53969 50223226
Removal of internal fixation 143.10 10.64 42 327887 38 50277157
Cardiac murmur 142.44 10.64 253 327676 10531 50266664
Tremor 142.28 10.64 335 327594 114568 50162627
Loss of consciousness 140.93 10.64 290 327639 104063 50173132
Appendix disorder 139.75 10.64 96 327833 1301 50275894
Appendicectomy 139.61 10.64 122 327807 2400 50274795
Breast disorder 139.29 10.64 111 327818 1911 50275284
Premature delivery 138.57 10.64 3 327926 23660 50253535
Drug ineffective 138.55 10.64 4152 323777 815181 49462014
Dental fistula 138.13 10.64 71 327858 538 50276657
Exposed bone in jaw 136.34 10.64 126 327803 2674 50274521
Hypersensitivity 135.53 10.64 2051 325878 213110 50064085
Abscess jaw 135.09 10.64 93 327836 1265 50275930
Dental necrosis 134.24 10.64 46 327883 98 50277097
Ulcer 133.16 10.64 358 327571 19842 50257353
Pruritus 132.04 10.64 1188 326741 282380 49994815
Cystocele 131.12 10.64 84 327845 1005 50276190
Lactic acidosis 130.98 10.64 28 327901 33327 50243868
Atrophic vulvovaginitis 130.49 10.64 97 327832 1499 50275696
Intervertebral disc protrusion 130.01 10.64 357 327572 20036 50257159
Skin necrosis 129.68 10.64 244 327685 10623 50266572
Leukopenia 129.28 10.64 148 327781 67380 50209815
Varicose vein 128.70 10.64 149 327780 4151 50273044
Multiple organ dysfunction syndrome 128.32 10.64 84 327845 50253 50226942
Hypercalcaemia 127.80 10.64 387 327542 22965 50254230
Hyperaesthesia teeth 127.58 10.64 94 327835 1432 50275763
Abscess 127.17 10.64 284 327645 13988 50263207
Neutrophil count decreased 126.87 10.64 70 327859 45956 50231239
Respiratory arrest 126.77 10.64 21 327908 29988 50247207
Pain 126.66 10.64 4761 323168 574142 49703053
Therapeutic product effect incomplete 125.54 10.64 252 327677 91263 50185932
Urticaria 125.50 10.64 425 327504 129136 50148059
Depressed level of consciousness 125.40 10.64 92 327837 51861 50225334
Femoral neck fracture 124.75 10.64 195 327734 7295 50269900
Dental implantation 123.56 10.64 66 327863 546 50276649
Cough 123.41 10.64 986 326943 240278 50036917
Weight decreased 123.19 10.64 883 327046 220362 50056833
Adverse drug reaction 123.04 10.64 693 327236 54529 50222666
Tachycardia 122.59 10.64 292 327637 99471 50177724
Folliculitis 121.96 10.64 541 327388 38684 50238511
Overdose 121.67 10.64 293 327636 99434 50177761
Intentional self-injury 121.36 10.64 7 327922 23105 50254090
Fractured sacrum 120.23 10.64 97 327832 1701 50275494
Dehydration 120.23 10.64 543 327386 151906 50125289
Hysterectomy 119.89 10.64 197 327732 7693 50269502
Sleep disorder due to general medical condition, insomnia type 117.59 10.64 459 327470 30988 50246207
Radiculopathy 116.79 10.64 152 327777 4789 50272406
Drug tolerance decreased 116.00 10.64 211 327718 8949 50268246
Joint effusion 115.90 10.64 259 327670 12762 50264433
Decreased appetite 115.71 10.64 794 327135 200129 50077066
Fistula 115.30 10.64 198 327731 8020 50269175
Seborrhoeic keratosis 115.13 10.64 96 327833 1767 50275428
Spinal fracture 114.99 10.64 288 327641 15285 50261910
Oestrogen deficiency 114.76 10.64 42 327887 117 50277078
Unevaluable event 114.57 10.64 79 327850 45987 50231208
Agitation 113.47 10.64 107 327822 53277 50223918
Neoplasm progression 113.42 10.64 25 327904 29132 50248063
Injection site swelling 113.03 10.64 65 327864 41708 50235487
Mucosal inflammation 112.18 10.64 60 327869 40082 50237113
Drug reaction with eosinophilia and systemic symptoms 111.32 10.64 24 327905 28400 50248795
Jaw operation 111.22 10.64 67 327862 713 50276482
Humerus fracture 110.12 10.64 186 327743 7432 50269763
Bone lesion 108.38 10.64 150 327779 5020 50272175
Rhinitis allergic 108.36 10.64 179 327750 7021 50270174
Psoriasis 108.08 10.64 175 327754 68825 50208370
Sedation 108.02 10.64 32 327897 30578 50246617
Respiratory failure 108.01 10.64 272 327657 90909 50186286
Vertebral foraminal stenosis 107.90 10.64 67 327862 756 50276439
Arthritis 107.83 10.64 944 326985 85777 50191418
Pulmonary embolism 106.60 10.64 322 327607 101382 50175813
Abdominal pain upper 105.41 10.64 603 327326 158706 50118489
Pulpitis dental 104.64 10.64 66 327863 767 50276428
Compression fracture 104.30 10.64 157 327772 5680 50271515
Suicidal ideation 104.27 10.64 123 327806 55262 50221933
Fracture 103.67 10.64 291 327638 16542 50260653
Oesophagitis 103.57 10.64 252 327677 13131 50264064
Multiple sclerosis relapse 102.51 10.64 77 327852 42887 50234308
Periodontal operation 102.01 10.64 28 327901 14 50277181
Hand fracture 100.28 10.64 134 327795 4334 50272861
Oral surgery 100.01 10.64 69 327860 942 50276253
Patella fracture 99.75 10.64 88 327841 1754 50275441
Abscess oral 99.33 10.64 77 327852 1271 50275924
Sopor 98.61 10.64 8 327921 19871 50257324
Dyslipidaemia 98.49 10.64 155 327774 5833 50271362
Vascular calcification 98.32 10.64 59 327870 623 50276572
Essential hypertension 97.78 10.64 132 327797 4312 50272883
Blister 97.62 10.64 913 327016 84505 50192690
Injection site reaction 97.57 10.64 108 327821 49924 50227271
Metabolic acidosis 97.33 10.64 66 327863 38759 50238436
Carotid bruit 96.69 10.64 57 327872 581 50276614
Drug resistance 96.01 10.64 7 327922 18982 50258213
Foot deformity 94.66 10.64 307 327622 18903 50258292
Peptic ulcer 94.62 10.64 121 327808 3745 50273450
Renal failure 94.49 10.64 363 327566 106270 50170925
Cognitive disorder 94.29 10.64 88 327841 44035 50233160
Ankle fracture 94.10 10.64 269 327660 15453 50261742
Accidental exposure to product 93.35 10.64 18 327911 23039 50254156
Osteomyelitis chronic 93.14 10.64 47 327882 341 50276854
Exposure during pregnancy 92.44 10.64 436 327493 120579 50156616
Septic shock 92.40 10.64 142 327787 57033 50220162
Endodontic procedure 92.16 10.64 101 327828 2645 50274550
Feeling hot 91.31 10.64 72 327857 39130 50238065
Gingival recession 91.21 10.64 72 327857 1222 50275973
Product use in unapproved indication 91.00 10.64 413 327516 115406 50161789
Renal impairment 90.93 10.64 224 327705 75437 50201758
Lower limb fracture 90.42 10.64 249 327680 13997 50263198
Gingival bleeding 90.24 10.64 216 327713 11137 50266058
Encephalopathy 89.02 10.64 54 327875 33657 50243538
Rectocele 88.71 10.64 61 327868 828 50276367
Arthralgia 88.38 10.64 3577 324352 435125 49842070
Influenza like illness 87.88 10.64 148 327781 57311 50219884
Haemoglobin decreased 87.69 10.64 475 327454 126741 50150454
Carpal tunnel syndrome 86.90 10.64 274 327655 16619 50260576
Illness 85.97 10.64 26 327903 24514 50252681
Chills 85.11 10.64 330 327599 96357 50180838
Caesarean section 84.43 10.64 4 327925 15635 50261560
Oroantral fistula 83.57 10.64 35 327894 154 50277041
Fracture malunion 83.13 10.64 34 327895 139 50277056
Sciatica 83.13 10.64 316 327613 21066 50256129
Pain in jaw 82.79 10.64 478 327451 37950 50239245
Bone metabolism disorder 82.03 10.64 40 327889 267 50276928
Blood glucose increased 81.97 10.64 216 327713 71108 50206087
Spinal laminectomy 81.89 10.64 52 327877 612 50276583
Extraskeletal ossification 81.86 10.64 30 327899 84 50277111
Oxygen saturation decreased 81.79 10.64 225 327704 73023 50204172
Hepatic failure 80.76 10.64 55 327874 32228 50244967
Blood creatinine increased 80.60 10.64 240 327689 75920 50201275
Acute sinusitis 80.25 10.64 107 327822 3453 50273742
Iliotibial band syndrome 80.23 10.64 34 327895 155 50277040
Drug withdrawal syndrome 80.19 10.64 31 327898 25050 50252145
Spinal disorder 79.86 10.64 170 327759 8100 50269095
Skin discolouration 79.06 10.64 58 327871 32699 50244496
Injection site pruritus 79.05 10.64 87 327842 40324 50236871
Chronic obstructive pulmonary disease 78.97 10.64 605 327324 52830 50224365
Injection site bruising 78.95 10.64 73 327856 36695 50240500
Therapy interrupted 78.95 10.64 17 327912 20135 50257060
Fluid retention 78.81 10.64 129 327800 50520 50226675
Blood pressure increased 78.63 10.64 522 327407 132610 50144585
Aortic arteriosclerosis 78.58 10.64 132 327797 5250 50271945
Spinal stenosis 78.35 10.64 229 327700 13321 50263874
Hepatocellular injury 78.24 10.64 35 327894 25912 50251283
Bradycardia 77.99 10.64 190 327739 64236 50212959
Dental plaque 77.83 10.64 28 327901 73 50277122
Drug ineffective for unapproved indication 77.40 10.64 21 327908 21260 50255935
Acetabulum fracture 77.26 10.64 36 327893 214 50276981
Tooth deposit 76.92 10.64 33 327896 156 50277039
Disturbance in attention 76.86 10.64 54 327875 31132 50246063
Osteoradionecrosis 76.26 10.64 29 327900 93 50277102
Osteopetrosis 76.18 10.64 21 327908 11 50277184
Joint swelling 75.91 10.64 2104 325825 243182 50034013
Peripheral vascular disorder 75.75 10.64 131 327798 5336 50271859
Depressed mood 74.91 10.64 66 327863 33957 50243238
Arthroscopy 74.38 10.64 48 327881 582 50276613
Hepatotoxicity 74.18 10.64 42 327887 27184 50250011
Gastritis 74.17 10.64 415 327514 32568 50244627
Toxic epidermal necrolysis 73.97 10.64 22 327907 20970 50256225
Nasal septum deviation 73.91 10.64 62 327867 1151 50276044
Lumbosacral radiculopathy 73.90 10.64 39 327890 314 50276881
Road traffic accident 73.53 10.64 333 327596 24019 50253176
Alveolar osteitis 73.21 10.64 42 327887 405 50276790
Chest discomfort 73.21 10.64 330 327599 92392 50184803
Renal cyst 73.10 10.64 169 327760 8518 50268677
Oedema mouth 71.32 10.64 81 327848 2209 50274986
Anaphylactic shock 71.25 10.64 21 327908 20134 50257061
Paraesthesia 70.73 10.64 472 327457 119771 50157424
Serotonin syndrome 70.44 10.64 36 327893 24677 50252518
Acquired oesophageal web 70.41 10.64 32 327897 178 50277017
Ascites 70.37 10.64 77 327852 35784 50241411
Breast conserving surgery 70.03 10.64 52 327877 802 50276393
Trismus 69.97 10.64 97 327832 3251 50273944
Generalised tonic-clonic seizure 69.68 10.64 42 327887 26268 50250927
Closed fracture manipulation 69.56 10.64 19 327910 9 50277186
Rash erythematous 69.31 10.64 74 327855 34778 50242417
Memory impairment 69.11 10.64 272 327657 79088 50198107
Posterior reversible encephalopathy syndrome 68.81 10.64 8 327921 14920 50262275
Actinomycosis 68.48 10.64 54 327875 915 50276280
Restlessness 68.34 10.64 39 327890 25134 50252061
Biopsy bone 68.28 10.64 22 327907 35 50277160
Jaw cyst 68.07 10.64 27 327902 100 50277095
Skeletal injury 68.01 10.64 57 327872 1057 50276138
Therapeutic product effect decreased 67.90 10.64 1249 326680 134801 50142394
Bone marrow failure 67.86 10.64 48 327881 27576 50249619
Red blood cell sedimentation rate abnormal 67.79 10.64 12 327917 16331 50260864
Nocturia 66.91 10.64 140 327789 6590 50270605
Pulmonary oedema 66.88 10.64 135 327794 48803 50228392
Clostridium difficile infection 66.82 10.64 41 327888 25398 50251797
Cholestasis 66.64 10.64 41 327888 25360 50251835
Bruxism 66.44 10.64 90 327839 2950 50274245
Carotid artery stenosis 66.39 10.64 114 327815 4617 50272578
Adenotonsillectomy 66.21 10.64 20 327909 22 50277173
Contusion 66.16 10.64 1058 326871 111125 50166070
Hypertonic bladder 65.84 10.64 89 327840 2911 50274284
Cardiac failure 65.34 10.64 262 327667 75778 50201417
Abdominal distension 65.32 10.64 247 327682 72656 50204539
Anaemia 64.36 10.64 1200 326729 251256 50025939
Urge incontinence 64.34 10.64 46 327883 667 50276528
Diabetic ketoacidosis 64.32 10.64 18 327911 17854 50259341
Type V hyperlipidaemia 64.16 10.64 38 327891 391 50276804
Angiopathy 64.09 10.64 104 327825 4018 50273177
Coronary artery disease 63.54 10.64 369 327560 29357 50247838
Eustachian tube dysfunction 63.47 10.64 36 327893 339 50276856
Bone formation decreased 63.12 10.64 23 327906 63 50277132
Epistaxis 63.11 10.64 208 327721 63746 50213449
Anaemia of chronic disease 62.65 10.64 68 327861 1761 50275434
Bone fragmentation 62.62 10.64 45 327884 658 50276537
Arteriosclerosis coronary artery 62.55 10.64 147 327782 7489 50269706
Incorrect dose administered 62.44 10.64 138 327791 48276 50228919
Intervertebral disc disorder 62.42 10.64 106 327823 4254 50272941
Product quality issue 61.95 10.64 65 327864 30793 50246402
Neutropenic sepsis 61.80 10.64 9 327920 14138 50263057
Joint dislocation 61.58 10.64 198 327731 12135 50265060
Therapy cessation 61.55 10.64 47 327882 25964 50251231
Skin ulcer 61.50 10.64 416 327513 34902 50242293
Tenosynovitis stenosans 61.48 10.64 74 327855 2150 50275045
Actinic keratosis 61.40 10.64 74 327855 2153 50275042
Hyperparathyroidism 61.37 10.64 77 327852 2337 50274858
Depression 61.10 10.64 1453 326476 163970 50113225
Osteoma 61.07 10.64 19 327910 25 50277170
Diverticulum intestinal 60.84 10.64 125 327804 5808 50271387
Palmar-plantar erythrodysaesthesia syndrome 60.77 10.64 27 327902 20071 50257124
Erythema 60.57 10.64 631 327298 145783 50131412
Breast calcifications 60.20 10.64 54 327875 1101 50276094
Transaminases increased 60.03 10.64 55 327874 27769 50249426
Burning sensation 59.89 10.64 128 327801 45318 50231877
Emphysema 59.77 10.64 161 327768 8932 50268263
Irritability 59.20 10.64 58 327871 28368 50248827
Polymyalgia rheumatica 59.07 10.64 79 327850 2557 50274638
Neurotoxicity 58.64 10.64 12 327917 14728 50262467
Plantar fasciitis 58.62 10.64 83 327846 2838 50274357
No adverse event 58.58 10.64 79 327850 33499 50243696
Device issue 58.57 10.64 28 327901 19944 50257251
Thoracic vertebral fracture 58.28 10.64 99 327830 3974 50273221
Toothache 57.89 10.64 240 327689 16654 50260541
Body height decreased 57.83 10.64 157 327772 8751 50268444
Oropharyngeal pain 57.82 10.64 283 327646 77518 50199677
Bone sequestrum 57.59 10.64 57 327872 1321 50275874
Influenza 57.53 10.64 342 327587 89196 50187999
Kyphoscoliosis 57.32 10.64 36 327893 415 50276780
Debridement 57.30 10.64 53 327876 1126 50276069
Postmenopause 57.25 10.64 19 327910 35 50277160
Intraocular lens implant 57.11 10.64 30 327899 239 50276956
Abnormal behaviour 56.98 10.64 28 327901 19630 50257565
Dyskinesia 56.71 10.64 58 327871 27803 50249392
Dysarthria 56.58 10.64 97 327832 37306 50239889
Atrophy 56.37 10.64 59 327870 1464 50275731
Upper limb fracture 56.37 10.64 228 327701 15645 50261550
Rash maculo-papular 55.90 10.64 54 327875 26587 50250608
Spinal meningeal cyst 55.36 10.64 18 327911 30 50277165
Oesophageal ulcer 55.28 10.64 95 327834 3850 50273345
Status epilepticus 55.26 10.64 10 327919 13396 50263799
Angioedema 54.92 10.64 100 327829 37576 50239619
Sequestrectomy 54.52 10.64 44 327885 772 50276423
Hyperkalaemia 54.22 10.64 147 327782 47942 50229253
Withdrawal syndrome 54.19 10.64 23 327906 17567 50259628
Aggression 54.13 10.64 35 327894 21081 50256114
Carotid artery disease 54.09 10.64 58 327871 1481 50275714
Vision blurred 53.98 10.64 294 327635 78353 50198842
Drug eruption 53.72 10.64 298 327631 23308 50253887
Heart rate increased 53.45 10.64 288 327641 76962 50200233
Haemorrhage 53.28 10.64 173 327756 53268 50223927
Creatinine renal clearance decreased 53.21 10.64 7 327922 11874 50265321
Hypervolaemia 53.14 10.64 52 327877 25447 50251748
Pleural effusion 52.92 10.64 310 327619 81144 50196051
Disorientation 52.78 10.64 93 327836 35391 50241804
Steroid therapy 52.62 10.64 20 327909 64 50277131
Biopsy breast 52.42 10.64 29 327900 259 50276936
Lung neoplasm 52.39 10.64 111 327818 5271 50271924
Neuropathy peripheral 52.39 10.64 389 327540 96368 50180827
Pernicious anaemia 52.12 10.64 39 327890 609 50276586
Myelosuppression 51.75 10.64 12 327917 13505 50263690
Cholecystectomy 51.67 10.64 155 327774 9148 50268047
Mastication disorder 51.60 10.64 62 327867 1798 50275397
Cytomegalovirus infection 51.44 10.64 26 327903 17936 50259259
Unresponsive to stimuli 51.41 10.64 74 327855 30535 50246660
Blood bilirubin increased 51.35 10.64 80 327849 31958 50245237
Pericardial effusion 51.26 10.64 54 327875 25535 50251660
Bunion operation 51.21 10.64 49 327880 1088 50276107
Blood pressure decreased 51.01 10.64 188 327741 55721 50221474
Psychotic disorder 50.87 10.64 40 327889 21772 50255423
Osteomalacia 50.86 10.64 39 327890 633 50276562
Acute hepatic failure 50.75 10.64 19 327910 15658 50261537
Drug level increased 50.68 10.64 31 327898 19237 50257958
Muscle spasticity 50.54 10.64 24 327905 17160 50260035
Pancreatitis 50.53 10.64 127 327802 42487 50234708
Urinary bladder suspension 50.39 10.64 33 327896 411 50276784
Mycotic allergy 50.19 10.64 42 327887 777 50276418
Red blood cell count decreased 50.04 10.64 89 327840 33746 50243449
Malocclusion 50.03 10.64 20 327909 76 50277119
Lymphocyte count decreased 49.96 10.64 58 327871 26249 50250946
Scapula fracture 49.94 10.64 32 327897 383 50276812
Gastrointestinal disorder 49.87 10.64 875 327054 93581 50183614
Lumbar vertebral fracture 49.69 10.64 99 327830 4498 50272697
Poisoning 49.69 10.64 10 327919 12419 50264776
Purulence 49.62 10.64 53 327876 1347 50275848
Gingival pain 49.61 10.64 116 327813 5890 50271305
Lacrimation increased 49.56 10.64 24 327905 16968 50260227
Joint injury 49.54 10.64 275 327654 21514 50255681
Shock 49.26 10.64 37 327892 20613 50256582
Vaginal haemorrhage 48.96 10.64 52 327877 24499 50252696
Altered state of consciousness 48.84 10.64 42 327887 21868 50255327
Osteogenesis imperfecta 48.75 10.64 29 327900 301 50276894
Pallor 48.70 10.64 47 327882 23152 50254043
Bladder repair 48.40 10.64 19 327910 68 50277127
Heavy menstrual bleeding 48.37 10.64 20 327909 15517 50261678
Scleritis 48.26 10.64 80 327849 3147 50274048
Mydriasis 48.23 10.64 6 327923 10621 50266574
Varicose vein operation 48.05 10.64 14 327915 12 50277183
Spinal fusion surgery 48.04 10.64 90 327839 3905 50273290
Bladder disorder 48.02 10.64 132 327797 7411 50269784
Dental prosthesis placement 47.97 10.64 18 327911 55 50277140
Dry skin 47.96 10.64 133 327796 43058 50234137
Oral fibroma 47.89 10.64 17 327912 42 50277153
Mood swings 47.35 10.64 22 327907 15932 50261263
Nasal congestion 47.23 10.64 171 327758 50949 50226246
Hepatitis 47.18 10.64 82 327847 31371 50245824
Back disorder 47.01 10.64 150 327779 9155 50268040
Crying 46.91 10.64 38 327891 20378 50256817
Meniscus removal 46.89 10.64 15 327914 23 50277172
Comminuted fracture 46.42 10.64 34 327895 513 50276682
Tendon disorder 46.40 10.64 105 327824 5217 50271978
Sjogren's syndrome 46.17 10.64 44 327885 972 50276223
Sinus disorder 46.07 10.64 239 327690 18219 50258976
Myoclonus 46.07 10.64 18 327911 14452 50262743
Injection site mass 45.96 10.64 22 327907 15658 50261537
Thyroid neoplasm 45.96 10.64 82 327847 3425 50273770
Onychomycosis 45.67 10.64 101 327828 4941 50272254
Adenoidal disorder 45.46 10.64 21 327908 122 50277073
Postmenopausal haemorrhage 45.38 10.64 60 327869 1920 50275275
Infusion site pain 45.25 10.64 12 327917 12334 50264861
Dermal cyst 44.99 10.64 52 327877 1446 50275749
Rhabdomyolysis 44.98 10.64 118 327811 38909 50238286
Full blood count decreased 44.93 10.64 47 327882 22299 50254896
Dysgeusia 44.59 10.64 118 327811 38798 50238397
Drug hypersensitivity 44.51 10.64 1262 326667 249748 50027447
Skin exfoliation 44.01 10.64 95 327834 33517 50243678
Acute respiratory distress syndrome 44.00 10.64 43 327886 21056 50256139
Impaired fasting glucose 43.78 10.64 22 327907 158 50277037
Oophorectomy 43.56 10.64 31 327898 446 50276749
Skin cancer 43.48 10.64 147 327782 9247 50267948
Colitis 43.26 10.64 118 327811 38411 50238784
Incisional drainage 43.23 10.64 29 327900 377 50276818
Barrett's oesophagus 43.22 10.64 34 327895 574 50276621
Body temperature increased 43.21 10.64 86 327843 31255 50245940
Goitre 43.13 10.64 102 327827 5218 50271977
Peripheral venous disease 43.10 10.64 105 327824 5475 50271720
Aphasia 43.00 10.64 74 327855 28420 50248775
Dystonia 42.94 10.64 12 327917 11914 50265281
Arteriosclerosis 42.87 10.64 143 327786 8934 50268261
Accidental overdose 42.87 10.64 38 327891 19495 50257700
Hypoglycaemia 42.70 10.64 190 327739 53391 50223804
Thrombosis 42.70 10.64 201 327728 55632 50221563
Injection site urticaria 42.69 10.64 13 327916 12204 50264991
Osteonecrosis of external auditory canal 42.66 10.64 18 327911 81 50277114
Epilepsy 42.65 10.64 46 327883 21521 50255674
Carpal tunnel decompression 42.54 10.64 37 327892 723 50276472
Intermittent claudication 42.41 10.64 53 327876 1602 50275593
Phlebolith 42.36 10.64 21 327908 146 50277049
Groin pain 41.93 10.64 140 327789 8751 50268444
Tooth infection 41.88 10.64 192 327737 13920 50263275
External fixation of fracture 41.87 10.64 11 327918 3 50277192
Tenosynovitis 41.78 10.64 157 327772 10408 50266787
Respiratory distress 41.75 10.64 84 327845 30405 50246790
Oesophageal disorder 41.70 10.64 59 327870 2016 50275179
Akathisia 41.70 10.64 3 327926 8226 50268969
Hypothermia 41.60 10.64 13 327916 12003 50265192
Heart rate decreased 41.57 10.64 111 327818 36386 50240809
Pneumonitis 41.53 10.64 80 327849 29430 50247765
Salpingo-oophorectomy bilateral 41.46 10.64 20 327909 130 50277065
Cerebral small vessel ischaemic disease 41.45 10.64 35 327894 656 50276539
Cytokine release syndrome 41.40 10.64 4 327925 8630 50268565
Injection site warmth 41.34 10.64 19 327910 13847 50263348
Osteomyelitis acute 41.34 10.64 23 327906 208 50276987
Condition aggravated 41.14 10.64 1542 326387 295516 49981679
Rhinorrhoea 41.05 10.64 183 327746 51400 50225795
Liver function test increased 40.98 10.64 64 327865 25542 50251653
Agranulocytosis 40.93 10.64 47 327882 21374 50255821
Iron deficiency anaemia 40.66 10.64 216 327713 16618 50260577
Drug-induced liver injury 40.56 10.64 75 327854 28020 50249175
Hormone therapy 40.46 10.64 10 327919 0 50277195
Breast cyst 40.45 10.64 50 327879 1494 50275701
Facet joint syndrome 40.43 10.64 63 327866 2350 50274845
Therapeutic response decreased 40.40 10.64 163 327766 47068 50230127
Skin laceration 40.33 10.64 234 327695 18608 50258587
Oesophageal stenosis 40.28 10.64 69 327860 2789 50274406
Uterine prolapse 40.10 10.64 43 327886 1098 50276097
Radiotherapy 40.04 10.64 25 327904 285 50276910
Brain oedema 40.03 10.64 15 327914 12355 50264840
COVID-19 pneumonia 39.96 10.64 4 327925 8391 50268804
Ovarian disorder 39.79 10.64 34 327895 648 50276547
Hair follicle tumour benign 39.67 10.64 27 327902 360 50276835
Vitamin B12 deficiency 39.56 10.64 82 327847 3834 50273361
Disease recurrence 39.53 10.64 43 327886 20038 50257157
Dental prosthesis user 39.47 10.64 15 327914 48 50277147
Device dislocation 39.33 10.64 49 327880 21497 50255698
Respiratory disorder 39.31 10.64 90 327839 31097 50246098
Enthesopathy 39.16 10.64 119 327810 7074 50270121
Dermal sinus 39.15 10.64 13 327916 24 50277171
Treatment failure 39.02 10.64 1168 326761 136469 50140726
Plasma cell myeloma 38.99 10.64 91 327838 31231 50245964
Spondylolysis 38.79 10.64 15 327914 51 50277144
Post procedural fever 38.68 10.64 25 327904 304 50276891
Therapeutic response unexpected 38.63 10.64 28 327901 15887 50261308
Neuroleptic malignant syndrome 38.61 10.64 12 327917 11118 50266077
Red blood cell sedimentation rate 38.49 10.64 77 327852 3509 50273686
Benign neoplasm of skin 38.46 10.64 19 327910 131 50277064
Knee deformity 38.40 10.64 40 327889 987 50276208
Rash macular 38.25 10.64 41 327888 19236 50257959
Traumatic ulcer 38.16 10.64 13 327916 27 50277168
Nightmare 38.15 10.64 29 327900 16057 50261138
Stevens-Johnson syndrome 38.12 10.64 51 327878 21701 50255494
Periarthritis 37.99 10.64 55 327874 1920 50275275
Atelectasis 37.88 10.64 225 327704 18045 50259150
Gamma-glutamyltransferase increased 37.73 10.64 85 327844 29538 50247657
Product storage error 37.63 10.64 16 327913 12208 50264987
Bone fistula 37.52 10.64 15 327914 57 50277138
Device difficult to use 37.40 10.64 9 327920 9877 50267318
Post procedural constipation 37.23 10.64 16 327913 76 50277119
Cardiogenic shock 37.15 10.64 28 327901 15571 50261624
Gestational diabetes 37.04 10.64 3 327926 7462 50269733
Cervicobrachial syndrome 36.99 10.64 35 327894 766 50276429
Blood glucose decreased 36.96 10.64 38 327891 18173 50259022
Hypophagia 36.61 10.64 78 327851 27650 50249545
Lethargy 36.61 10.64 180 327749 49252 50227943
Periostitis 36.56 10.64 23 327906 266 50276929
Melanocytic naevus 36.54 10.64 79 327850 3805 50273390
Epicondylitis 36.49 10.64 53 327876 1856 50275339
Tongue disorder 36.48 10.64 137 327792 9079 50268116
Gingival abscess 36.46 10.64 33 327896 681 50276514
Abortion induced 36.36 10.64 8 327921 9336 50267859
Toxic skin eruption 35.81 10.64 14 327915 11237 50265958
Hypercalciuria 35.71 10.64 21 327908 213 50276982
Chondrocalcinosis 35.67 10.64 30 327899 559 50276636
Skin abrasion 35.52 10.64 125 327804 8025 50269170
Inappropriate schedule of product administration 35.07 10.64 297 327632 71534 50205661
Respiratory depression 34.97 10.64 17 327912 11993 50265202
Circulatory collapse 34.94 10.64 47 327882 19953 50257242
Acrochordon 34.88 10.64 35 327894 825 50276370
Injection site rash 34.87 10.64 32 327897 16145 50261050
Cyst 34.83 10.64 164 327765 12023 50265172
Tooth impacted 34.80 10.64 17 327912 114 50277081
Haematotoxicity 34.54 10.64 5 327924 7890 50269305
Senile osteoporosis 34.42 10.64 20 327909 198 50276997
Throat irritation 34.41 10.64 92 327837 30147 50247048
Anuria 34.16 10.64 15 327914 11229 50265966
Hemiparesis 34.13 10.64 48 327881 20000 50257195
Product prescribing error 33.91 10.64 52 327877 20909 50256286
Ilium fracture 33.84 10.64 17 327912 122 50277073
Traumatic fracture 33.76 10.64 29 327900 557 50276638
Post laminectomy syndrome 33.75 10.64 20 327909 206 50276989
Anxiety disorder 33.75 10.64 74 327855 3599 50273596
Glaucoma 33.70 10.64 195 327734 15491 50261704
Throat tightness 33.46 10.64 52 327877 20795 50256400
Trigger finger 33.32 10.64 75 327854 3713 50273482
Cytopenia 33.18 10.64 8 327921 8767 50268428
Neurectomy 33.13 10.64 9 327920 4 50277191
Mood altered 32.97 10.64 21 327908 12752 50264443
Metastases to central nervous system 32.80 10.64 16 327913 11266 50265929
Bone formation increased 32.80 10.64 18 327911 158 50277037
Torsade de pointes 32.61 10.64 18 327911 11817 50265378
Leukoplakia 32.50 10.64 14 327915 67 50277128
Morton's neuralgia 32.50 10.64 14 327915 67 50277128
Neuroma 32.50 10.64 24 327905 367 50276828
Hepatic encephalopathy 32.35 10.64 11 327918 9625 50267570
Chondromalacia 32.31 10.64 21 327908 258 50276937
Mammogram abnormal 32.25 10.64 30 327899 642 50276553
Hallucination 32.23 10.64 174 327755 46483 50230712
Transplant rejection 32.20 10.64 11 327918 9598 50267597
Increased tendency to bruise 32.12 10.64 133 327796 9223 50267972
Left ventricular hypertrophy 32.06 10.64 86 327843 4759 50272436
Stasis dermatitis 31.98 10.64 29 327900 600 50276595
Multiple fractures 31.98 10.64 105 327824 6506 50270689
Frequent bowel movements 31.86 10.64 26 327903 13892 50263303
Labelled drug-drug interaction medication error 31.79 10.64 14 327915 10463 50266732
Tumour lysis syndrome 31.77 10.64 5 327924 7416 50269779
Laboratory test abnormal 31.72 10.64 64 327865 23144 50254051
Schizophrenia 31.64 10.64 5 327924 7392 50269803
Cervical spinal stenosis 31.55 10.64 50 327879 1893 50275302
Radicular pain 31.48 10.64 24 327905 386 50276809
Dental alveolar anomaly 31.44 10.64 13 327916 55 50277140
Thrombotic microangiopathy 31.36 10.64 9 327920 8782 50268413
Right ventricular failure 31.32 10.64 34 327895 15859 50261336
Second primary malignancy 31.14 10.64 4 327925 6910 50270285
Orthostatic hypotension 31.11 10.64 93 327836 29388 50247807
Glucose tolerance impaired 31.04 10.64 88 327841 5030 50272165
Chronic sinusitis 30.99 10.64 99 327830 6046 50271149
Ejection fraction decreased 30.88 10.64 45 327884 18475 50258720
Limb injury 30.87 10.64 231 327698 20019 50257176
Haemorrhoid operation 30.83 10.64 22 327907 318 50276877
Hyperparathyroidism primary 30.77 10.64 22 327907 319 50276876
Metastases to liver 30.53 10.64 52 327877 20052 50257143
Acne 30.39 10.64 50 327879 19545 50257650
Renal injury 30.38 10.64 9 327920 8602 50268593
Hypoxia 30.38 10.64 200 327729 50923 50226272
Hyperbilirubinaemia 30.31 10.64 12 327917 9558 50267637
Device malfunction 30.18 10.64 32 327897 15089 50262106
Oliguria 30.08 10.64 8 327921 8208 50268987
Vertebroplasty 30.05 10.64 21 327908 293 50276902
Metastases to lung 30.02 10.64 17 327912 11003 50266192
Acute myeloid leukaemia 29.98 10.64 32 327897 15042 50262153
Breast mass 29.92 10.64 101 327828 6348 50270847
Gingivectomy 29.84 10.64 8 327921 3 50277192
Normal newborn 29.83 10.64 4 327925 6687 50270508
Vaginal disorder 29.73 10.64 29 327900 660 50276535
Avulsion fracture 29.69 10.64 20 327909 262 50276933
Haematochezia 29.66 10.64 145 327784 39737 50237458
Bone atrophy 29.60 10.64 10 327919 20 50277175
Incorrect route of product administration 29.54 10.64 47 327882 18619 50258576
Eosinophilia 29.48 10.64 47 327882 18605 50258590
Mitral valve incompetence 29.35 10.64 204 327725 17267 50259928
Synovial fluid analysis 29.18 10.64 44 327885 1594 50275601
Jaw fistula 29.16 10.64 12 327917 50 50277145
Genital haemorrhage 29.14 10.64 4 327925 6570 50270625
Petechiae 29.11 10.64 23 327906 12489 50264706
Palpitations 29.01 10.64 434 327495 94072 50183123
Affect lability 28.97 10.64 11 327918 8987 50268208
Gingival swelling 28.87 10.64 71 327858 3724 50273471
Taste disorder 28.83 10.64 9 327920 8315 50268880
Tardive dyskinesia 28.80 10.64 6 327923 7273 50269922
Lipoma 28.35 10.64 50 327879 2069 50275126
Ischaemic stroke 28.35 10.64 37 327892 15911 50261284
Benign breast lump removal 28.32 10.64 7 327922 0 50277195
Syncope 28.28 10.64 483 327446 102519 50174676
Enterocele 28.27 10.64 12 327917 55 50277140
Vertigo positional 28.26 10.64 55 327874 2456 50274739
Rectal polyp 28.26 10.64 33 327896 928 50276267
Poor dental condition 28.21 10.64 20 327909 286 50276909
Mental impairment 28.19 10.64 22 327907 12022 50265173
Dyspnoea exertional 28.19 10.64 205 327724 51028 50226167
Face oedema 28.15 10.64 45 327884 17794 50259401
Urinary tract infection 28.13 10.64 1176 326753 222844 50054351
Urethral caruncle 28.08 10.64 13 327916 76 50277119
Dialysis 28.03 10.64 13 327916 9425 50267770
Granuloma 27.99 10.64 82 327847 4776 50272419
Amenorrhoea 27.94 10.64 10 327919 8474 50268721
Rhinoplasty 27.93 10.64 8 327921 6 50277189
White blood cell count increased 27.83 10.64 160 327769 42080 50235115
Tachypnoea 27.83 10.64 32 327897 14545 50262650
Immunodeficiency 27.83 10.64 33 327896 14795 50262400
Blood pressure abnormal 27.73 10.64 25 327904 12722 50264473
Rotator cuff repair 27.64 10.64 44 327885 1672 50275523
Oesophageal discomfort 27.48 10.64 16 327913 159 50277036
Uterine dilation and curettage 27.42 10.64 31 327898 841 50276354
Blood 25-hydroxycholecalciferol decreased 27.28 10.64 12 327917 61 50277134
Hyperthermia 27.23 10.64 8 327921 7688 50269507
Blood creatine phosphokinase increased 27.23 10.64 84 327845 26283 50250912
Haemophagocytic lymphohistiocytosis 27.06 10.64 11 327918 8622 50268573
Muscle rigidity 27.01 10.64 15 327914 9814 50267381
Pulmonary arterial hypertension 26.96 10.64 57 327872 20262 50256933
Sialoadenitis 26.95 10.64 39 327890 1361 50275834
Product dispensing error 26.79 10.64 12 327917 8879 50268316
Eye pruritus 26.77 10.64 25 327904 12509 50264686
Meralgia paraesthetica 26.74 10.64 15 327914 138 50277057
Oesophageal carcinoma 26.69 10.64 34 327895 1048 50276147
International normalised ratio increased 26.57 10.64 167 327762 42985 50234210
Myofascial pain syndrome 26.40 10.64 48 327881 2035 50275160
Joint dislocation reduction 26.39 10.64 8 327921 9 50277186
Neuritis 26.19 10.64 30 327899 826 50276369
Weight increased 26.16 10.64 1056 326873 200835 50076360
Impaired quality of life 26.11 10.64 4 327925 6052 50271143
Rhinitis perennial 26.01 10.64 9 327920 20 50277175
Lymphopenia 26.00 10.64 38 327891 15583 50261612
Raynaud's phenomenon 25.98 10.64 35 327894 1141 50276054
Head discomfort 25.96 10.64 20 327909 10999 50266196
Infusion site erythema 25.95 10.64 12 327917 8715 50268480
Lip neoplasm 25.94 10.64 8 327921 10 50277185
Pancreatitis acute 25.94 10.64 74 327855 23738 50253457
Injection site induration 25.83 10.64 11 327918 8386 50268809
Restless legs syndrome 25.76 10.64 184 327745 15713 50261482
Hypersomnia 25.74 10.64 37 327892 15277 50261918
Face injury 25.72 10.64 56 327873 2710 50274485
Cataract nuclear 25.71 10.64 30 327899 843 50276352
Mixed incontinence 25.66 10.64 12 327917 72 50277123
Constipation 25.66 10.64 964 326965 184744 50092451
Skin fissures 25.65 10.64 12 327917 8656 50268539
Clavicle fracture 25.64 10.64 58 327871 2881 50274314
Therapeutic response shortened 25.57 10.64 8 327921 7381 50269814
Haemodynamic instability 25.51 10.64 10 327919 8014 50269181
Vulvovaginal dryness 25.49 10.64 49 327880 2168 50275027
Osteosclerosis 25.47 10.64 64 327865 3403 50273792
Bone scan abnormal 25.41 10.64 20 327909 338 50276857
Miosis 25.39 10.64 5 327924 6305 50270890
Haemoptysis 25.34 10.64 83 327846 25490 50251705
Nasal disorder 25.30 10.64 50 327879 2258 50274937
Forearm fracture 25.29 10.64 22 327907 430 50276765
Cervical polyp 25.29 10.64 16 327913 187 50277008
Intestinal obstruction 25.20 10.64 87 327842 26296 50250899
Myocarditis 25.11 10.64 10 327919 7937 50269258
Reversible airways obstruction 25.08 10.64 32 327897 988 50276207
Injection site haemorrhage 25.01 10.64 64 327865 21282 50255913
Cerebrovascular disorder 24.90 10.64 53 327876 2525 50274670
Fibroadenoma of breast 24.63 10.64 20 327909 354 50276841
Skin burning sensation 24.62 10.64 18 327911 10167 50267028
Hallucination, auditory 24.61 10.64 20 327909 10708 50266487
Menopausal symptoms 24.53 10.64 46 327883 1997 50275198
Enchondromatosis 24.53 10.64 11 327918 59 50277136
Pulmonary congestion 24.50 10.64 38 327891 15209 50261986
Bradyphrenia 24.49 10.64 5 327924 6147 50271048
Trigeminal neuralgia 24.47 10.64 59 327870 3056 50274139
Grief reaction 24.38 10.64 16 327913 200 50276995
Dupuytren's contracture 24.38 10.64 12 327917 82 50277113
Malpositioned teeth 24.36 10.64 8 327921 14 50277181
Progressive multifocal leukoencephalopathy 24.30 10.64 23 327906 11434 50265761
Metastases to bone 24.28 10.64 50 327879 17945 50259250
Tendon sheath lesion excision 24.27 10.64 6 327923 0 50277195
Traumatic occlusion 24.27 10.64 6 327923 0 50277195
Radiotherapy to breast 24.27 10.64 6 327923 0 50277195
Generalised oedema 24.26 10.64 32 327897 13699 50263496
Blood lactate dehydrogenase increased 24.21 10.64 57 327872 19505 50257690
Adenoidectomy 24.19 10.64 13 327916 109 50277086
Dental pulp disorder 24.02 10.64 7 327922 6 50277189
Fracture reduction 24.02 10.64 7 327922 6 50277189
Pre-existing condition improved 24 10.64 8 327921 7089 50270106
Nasopharyngitis 23.95 10.64 1014 326915 191913 50085282
Photosensitivity reaction 23.94 10.64 29 327900 12882 50264313
Incision site haematoma 23.94 10.64 11 327918 63 50277132
Uterine leiomyoma 23.89 10.64 108 327821 7783 50269412
Complication of device insertion 23.86 10.64 5 327924 6036 50271159
Aplastic anaemia 23.84 10.64 10 327919 7693 50269502
Leukoplakia oral 23.81 10.64 14 327915 142 50277053
Osteitis deformans 23.79 10.64 16 327913 209 50276986
Device occlusion 23.76 10.64 5 327924 6018 50271177
Pain in extremity 23.76 10.64 2065 325864 270800 50006395
Inflammatory marker increased 23.67 10.64 4 327925 5630 50271565
Palatal disorder 23.63 10.64 17 327912 249 50276946
Myocardial infarction 23.63 10.64 420 327509 88607 50188588
Coma 23.55 10.64 245 327684 56634 50220561
Hyperkeratosis 23.49 10.64 79 327850 4956 50272239
Hypertensive heart disease 23.48 10.64 48 327881 2222 50274973
Urine calcium increased 23.36 10.64 10 327919 47 50277148
Joint arthroplasty 23.28 10.64 46 327883 2077 50275118
Dementia Alzheimer's type 23.19 10.64 31 327898 1003 50276192
Bacteraemia 23.16 10.64 36 327893 14397 50262798
Bone infarction 23.16 10.64 16 327913 219 50276976
Hormone level abnormal 22.89 10.64 46 327883 2103 50275092
Hypertensive crisis 22.89 10.64 31 327898 13123 50264072
Glomerular filtration rate decreased 22.88 10.64 25 327904 11627 50265568
Swelling face 22.83 10.64 224 327705 52371 50224824
Reflux laryngitis 22.80 10.64 12 327917 96 50277099
Hepatic cytolysis 22.80 10.64 12 327917 8091 50269104
Night sweats 22.75 10.64 126 327803 33448 50243747
Maternal drugs affecting foetus 22.72 10.64 3 327926 5074 50272121
Presbyopia 22.71 10.64 21 327908 446 50276749
Haemodialysis 22.63 10.64 13 327916 8349 50268846
Productive cough 22.63 10.64 225 327704 52469 50224726
Sinus tarsi syndrome 22.59 10.64 7 327922 9 50277186
Oophorectomy bilateral 22.55 10.64 9 327920 34 50277161
Aortic stenosis 22.47 10.64 69 327860 4125 50273070
Muscle twitching 22.45 10.64 41 327888 15390 50261805
Neutrophil count increased 22.22 10.64 36 327893 14159 50263036
Red cell distribution width increased 22.19 10.64 14 327915 8545 50268650
Benign neoplasm 22.18 10.64 28 327901 855 50276340
Mental status changes 22.01 10.64 141 327788 36131 50241064
Cervical radiculopathy 21.99 10.64 27 327902 801 50276394
Persistent depressive disorder 21.98 10.64 28 327901 863 50276332
Benign bone neoplasm 21.97 10.64 9 327920 37 50277158
Cataract cortical 21.97 10.64 9 327920 37 50277158
Pharyngeal oedema 21.94 10.64 32 327897 13133 50264062
Mania 21.90 10.64 23 327906 10893 50266302
Pathogen resistance 21.88 10.64 5 327924 5684 50271511
Osteorrhagia 21.86 10.64 6 327923 3 50277192
Incision site cellulitis 21.85 10.64 13 327916 135 50277060
Dystrophic calcification 21.80 10.64 12 327917 106 50277089
Hyperaesthesia 21.71 10.64 13 327916 8160 50269035
Spondylitis 21.65 10.64 53 327876 2772 50274423
Anger 21.50 10.64 25 327904 11308 50265887
Ventricular fibrillation 21.46 10.64 22 327907 10537 50266658
Hypoaesthesia 21.46 10.64 644 327285 126613 50150582
Odontogenic cyst 21.43 10.64 8 327921 24 50277171
Laryngeal ulceration 21.41 10.64 7 327922 12 50277183
Splenic granuloma 21.41 10.64 7 327922 12 50277183
Bone sarcoma 21.41 10.64 7 327922 12 50277183
Mental disorder 21.36 10.64 72 327857 21919 50255276
Kidney infection 21.35 10.64 57 327872 18689 50258506
Lenticular opacities 21.33 10.64 14 327915 175 50277020
Therapy change 21.32 10.64 4 327925 5221 50271974
Injection site extravasation 21.27 10.64 11 327918 7490 50269705
Extrapyramidal disorder 21.24 10.64 27 327902 11743 50265452
Metatarsalgia 21.21 10.64 16 327913 253 50276942
Acute respiratory failure 21.20 10.64 105 327824 28677 50248518
Infusion site swelling 21.14 10.64 10 327919 7166 50270029
Otitis externa 21.12 10.64 37 327892 1523 50275672
Musculoskeletal discomfort 21.07 10.64 167 327762 14731 50262464
Wound drainage 20.97 10.64 25 327904 719 50276476
Eye swelling 20.93 10.64 64 327865 20080 50257115
Inguinal hernia repair 20.90 10.64 9 327920 43 50277152
Renal tubular necrosis 20.88 10.64 21 327908 10147 50267048
Intervertebral disc space narrowing 20.87 10.64 28 327901 909 50276286
Blood pressure fluctuation 20.85 10.64 141 327788 35682 50241513
Bone marrow oedema 20.75 10.64 26 327903 788 50276407
Adjustment disorder with depressed mood 20.73 10.64 52 327877 2762 50274433
Cardiac failure acute 20.71 10.64 14 327915 8236 50268959
Facial bones fracture 20.63 10.64 56 327873 3121 50274074
Drug tolerance 20.56 10.64 75 327854 4901 50272294
Psychomotor hyperactivity 20.52 10.64 18 327911 9283 50267912
Traumatic arthritis 20.51 10.64 8 327921 28 50277167
Dysstasia 20.43 10.64 54 327875 17765 50259430
Vital capacity decreased 20.43 10.64 28 327901 928 50276267
Hospice care 20.43 10.64 6 327923 5766 50271429
Infective pulmonary exacerbation of cystic fibrosis 20.42 10.64 13 327916 7896 50269299
Tooth resorption 20.42 10.64 9 327920 46 50277149
Delusion 20.40 10.64 23 327906 10546 50266649
Oesophageal injury 20.30 10.64 8 327921 29 50277166
Emotional distress 20.29 10.64 106 327823 28557 50248638
SARS-CoV-2 test positive 20.27 10.64 3 327926 4656 50272539
Blood potassium decreased 20.24 10.64 148 327781 36797 50240398
End stage renal disease 20.24 10.64 6 327923 5731 50271464
Fibrous dysplasia of bone 20.23 10.64 5 327924 0 50277195
Chondroplasty 20.23 10.64 5 327924 0 50277195
Apicectomy 20.23 10.64 5 327924 0 50277195
Gastrooesophageal cancer 20.23 10.64 5 327924 0 50277195
Hypoparathyroidism 20.20 10.64 22 327907 572 50276623
Parathyroidectomy 20.17 10.64 15 327914 232 50276963
Actinic elastosis 20.15 10.64 6 327923 6 50277189
Infusion site extravasation 20.12 10.64 10 327919 6966 50270229
Oesophageal ulcer haemorrhage 20.11 10.64 18 327911 366 50276829
Breath odour 20.10 10.64 32 327897 1216 50275979
X-ray of pelvis and hip abnormal 20.10 10.64 7 327922 16 50277179
Underdose 19.96 10.64 66 327863 20212 50256983
Skin plaque 19.93 10.64 8 327921 6320 50270875
Spinal decompression 19.78 10.64 13 327916 163 50277032
Uterovaginal prolapse 19.77 10.64 10 327919 73 50277122
Denture wearer 19.76 10.64 14 327915 200 50276995
Bedridden 19.63 10.64 19 327910 9348 50267847
Lacunar infarction 19.63 10.64 54 327875 3033 50274162
Joint surgery 19.60 10.64 17 327912 331 50276864
Foreign body 19.59 10.64 41 327888 1930 50275265
Sickle cell anaemia with crisis 19.59 10.64 3 327926 4540 50272655
Nervous system disorder 19.50 10.64 48 327881 16175 50261020
Pharyngitis streptococcal 19.49 10.64 17 327912 8791 50268404
Paranoia 19.45 10.64 23 327906 10325 50266870
Bladder prolapse 19.42 10.64 39 327890 1782 50275413
Pneumonia viral 19.41 10.64 10 327919 6824 50270371
Drug level decreased 19.40 10.64 9 327920 6524 50270671
Abdominal hernia 19.36 10.64 68 327861 4361 50272834
Hemiplegia 19.24 10.64 12 327917 7369 50269826
Otitis media 19.21 10.64 67 327862 4282 50272913
Bronchitis chronic 19.13 10.64 62 327867 3815 50273380
Graft versus host disease 19.09 10.64 8 327921 6158 50271037
Therapy non-responder 19.05 10.64 225 327704 50797 50226398
Immune reconstitution inflammatory syndrome 19.04 10.64 6 327923 5510 50271685
Stress 19.03 10.64 240 327689 53553 50223642
Gingival ulceration 18.98 10.64 25 327904 797 50276398
Electrolyte imbalance 18.96 10.64 53 327876 17116 50260079
Intestinal perforation 18.95 10.64 24 327905 10455 50266740
Oesophageal perforation 18.93 10.64 15 327914 256 50276939
Aortic valve incompetence 18.92 10.64 78 327851 5398 50271797
Retching 18.87 10.64 34 327895 12828 50264367
Bone cyst 18.85 10.64 41 327888 1983 50275212
Labyrinthitis 18.85 10.64 43 327886 2148 50275047
Labile hypertension 18.80 10.64 19 327910 452 50276743
Sight disability 18.75 10.64 11 327918 111 50277084
Haematocrit decreased 18.74 10.64 141 327788 34835 50242360
Thermohypoaesthesia 18.67 10.64 11 327918 112 50277083
Increased appetite 18.67 10.64 16 327913 8345 50268850
Benign breast neoplasm 18.67 10.64 29 327900 1079 50276116
Hereditary angioedema 18.64 10.64 6 327923 5436 50271759
Colitis ulcerative 18.63 10.64 52 327877 16802 50260393
Muscle spasms 18.63 10.64 646 327283 124907 50152288
Multiple sclerosis 18.63 10.64 69 327860 20424 50256771
Cold sweat 18.61 10.64 25 327904 10619 50266576
Jaundice 18.57 10.64 98 327831 26331 50250864
Hypocalcaemia 18.52 10.64 100 327829 26716 50250479
Purulent discharge 18.50 10.64 66 327863 4266 50272929
Spinal claudication 18.47 10.64 9 327920 60 50277135
Klebsiella infection 18.34 10.64 12 327917 7182 50270013
Skin graft 18.33 10.64 20 327909 521 50276674
Bursa disorder 18.26 10.64 11 327918 117 50277078
Oral pain 18.25 10.64 245 327684 24788 50252407
Oral discharge 18.22 10.64 12 327917 151 50277044
Cyanosis 18.19 10.64 45 327884 15139 50262056
Suspected suicide 18.18 10.64 6 327923 5351 50271844
Electrocardiogram QRS complex prolonged 18.11 10.64 6 327923 5338 50271857
Mouth cyst 18.11 10.64 10 327919 89 50277106
Sacroiliitis 18.10 10.64 47 327882 2550 50274645
Catheter site infection 18.10 10.64 3 327926 4283 50272912
Device extrusion 18.06 10.64 7 327922 24 50277171
Aortic aneurysm 17.96 10.64 54 327875 3191 50274004
Liver function test abnormal 17.94 10.64 192 327737 44147 50233048
Central nervous system lesion 17.93 10.64 21 327908 9468 50267727
Blood creatinine decreased 17.93 10.64 5 327924 4971 50272224
Vaginal prolapse 17.86 10.64 17 327912 375 50276820
Speech disorder 17.79 10.64 146 327783 35402 50241793
Major depression 17.78 10.64 90 327839 6794 50270401
Temperature regulation disorder 17.76 10.64 3 327926 4224 50272971
Tendon sheath incision 17.76 10.64 9 327920 66 50277129
Ill-defined disorder 17.75 10.64 472 327457 54182 50223013
Carotid endarterectomy 17.72 10.64 11 327918 124 50277071
Dislocation of vertebra 17.68 10.64 52 327877 3035 50274160
Parathyroid disorder 17.65 10.64 20 327909 544 50276651
Vertebrobasilar insufficiency 17.64 10.64 9 327920 67 50277128
Parathyroid tumour benign 17.64 10.64 21 327908 603 50276592
Localised infection 17.62 10.64 95 327834 25390 50251805
Clonus 17.46 10.64 3 327926 4172 50273023
Glycosylated haemoglobin increased 17.46 10.64 26 327903 10580 50266615
Shock haemorrhagic 17.40 10.64 17 327912 8327 50268868
Large intestine benign neoplasm 17.38 10.64 10 327919 97 50277098
Cerebrovascular accident 17.26 10.64 474 327455 94206 50182989
Hepatomegaly 17.24 10.64 27 327902 10766 50266429
Gouty arthritis 17.23 10.64 19 327910 501 50276694
Hot flush 17.18 10.64 193 327736 43976 50233219
Haemolytic anaemia 17.10 10.64 21 327908 9271 50267924
Skin haemorrhage 17.02 10.64 12 327917 6906 50270289
Artificial crown procedure 17.00 10.64 14 327915 253 50276942
Tongue geographic 17.00 10.64 9 327920 73 50277122
Oesophageal haemorrhage 17.00 10.64 19 327910 509 50276686
Chondrocalcinosis pyrophosphate 16.98 10.64 27 327902 1025 50276170
Atrial septal defect 16.96 10.64 10 327919 6331 50270864
White blood cell count abnormal 16.94 10.64 7 327922 5433 50271762
Breast fibrosis 16.85 10.64 6 327923 15 50277180
Respiratory acidosis 16.85 10.64 9 327920 6019 50271176
Neurosensory hypoacusis 16.80 10.64 13 327916 214 50276981
Dermatitis acneiform 16.78 10.64 3 327926 4054 50273141
Emotional disorder 16.73 10.64 32 327897 11804 50265391
Pulmonary granuloma 16.73 10.64 30 327899 1258 50275937
Hypergammaglobulinaemia benign monoclonal 16.69 10.64 21 327908 639 50276556
Anxiety 16.69 10.64 1352 326577 176254 50100941
Fallopian tube disorder 16.69 10.64 14 327915 260 50276935
Expired product administered 16.64 10.64 7 327922 5375 50271820
Cholecystitis chronic 16.61 10.64 23 327906 9646 50267549
Mastoid disorder 16.58 10.64 6 327923 16 50277179
Gastric ulcer 16.57 10.64 211 327718 21094 50256101
Aspergillus infection 16.56 10.64 12 327917 6809 50270386
Hyperammonaemia 16.55 10.64 5 327924 4719 50272476
Ureterolithiasis 16.55 10.64 35 327894 1660 50275535
Feeding disorder 16.53 10.64 27 327902 10586 50266609
Intermenstrual bleeding 16.52 10.64 12 327917 6802 50270393
Wrong product administered 16.52 10.64 7 327922 5353 50271842
Vascular operation 16.40 10.64 9 327920 79 50277116
Urinary tract discomfort 16.40 10.64 13 327916 222 50276973
Foot operation 16.37 10.64 75 327854 5435 50271760
Thalassaemia beta 16.32 10.64 5 327924 6 50277189
Mastectomy 16.32 10.64 32 327897 1437 50275758
Atrioventricular block 16.25 10.64 11 327918 6467 50270728
Tooth discolouration 16.22 10.64 24 327905 855 50276340
Rash papular 16.19 10.64 36 327893 12568 50264627
Apathy 16.18 10.64 15 327914 7533 50269662
Reaction to food additive 16.18 10.64 4 327925 0 50277195
Uterine cervix atrophy 16.18 10.64 4 327925 0 50277195
Loss of anatomical alignment after fracture reduction 16.18 10.64 4 327925 0 50277195
Metatarsus primus varus 16.18 10.64 4 327925 0 50277195
Intervertebral disc annular tear 16.18 10.64 4 327925 0 50277195
Impacted fracture 16.18 10.64 4 327925 0 50277195
Arthrotomy 16.18 10.64 4 327925 0 50277195
Lipoma of breast 16.18 10.64 4 327925 0 50277195
Peripheral coldness 16.17 10.64 26 327903 10257 50266938
Needle issue 16.15 10.64 14 327915 7261 50269934
Ear disorder 16.13 10.64 52 327877 3191 50274004
Salivary gland mass 16.12 10.64 9 327920 82 50277113
Inflammation 16.12 10.64 483 327446 56429 50220766
Spinal deformity 16.11 10.64 25 327904 929 50276266
Menstruation irregular 16.09 10.64 10 327919 6152 50271043
Rosacea 16.06 10.64 57 327872 3674 50273521
Disseminated intravascular coagulation 16.03 10.64 57 327872 17078 50260117
Repetitive strain injury 16.02 10.64 11 327918 149 50277046
Injection site discolouration 16.00 10.64 13 327916 6961 50270234
Incorrect product administration duration 16.00 10.64 22 327907 9253 50267942
Urinary bladder polyp 15.97 10.64 8 327921 57 50277138
Embolism 15.97 10.64 13 327916 6955 50270240
Sputum culture positive 15.95 10.64 31 327898 1383 50275812
Fibromyalgia 15.95 10.64 393 327536 44585 50232610
Hepatic necrosis 15.94 10.64 7 327922 5241 50271954
Cushingoid 15.87 10.64 85 327844 6560 50270635
Urinary incontinence 15.85 10.64 264 327665 27944 50249251
Eustachian tube disorder 15.85 10.64 9 327920 85 50277110
Vitreous degeneration 15.83 10.64 6 327923 19 50277176
Blood alkaline phosphatase increased 15.79 10.64 161 327768 37365 50239830
Erosive oesophagitis 15.73 10.64 33 327896 1556 50275639
Inappropriate antidiuretic hormone secretion 15.71 10.64 39 327890 13104 50264091
Dermatitis bullous 15.68 10.64 14 327915 7159 50270036
Middle insomnia 15.68 10.64 25 327904 9896 50267299
Live birth 15.64 10.64 169 327760 16239 50260956
Staphylococcal bacteraemia 15.64 10.64 6 327923 4871 50272324
Delirium 15.61 10.64 165 327764 38027 50239168
Post transplant lymphoproliferative disorder 15.57 10.64 4 327925 4200 50272995
Uterine polyp 15.54 10.64 35 327894 1733 50275462
Tumour marker increased 15.54 10.64 3 327926 3837 50273358
Cerebral haemorrhage 15.49 10.64 107 327822 26945 50250250
Hip deformity 15.43 10.64 12 327917 199 50276996
Stress cardiomyopathy 15.40 10.64 17 327912 7870 50269325
Pelvic floor muscle weakness 15.39 10.64 7 327922 39 50277156
Intervertebral disc displacement 15.38 10.64 16 327913 394 50276801
Haemolysis 15.38 10.64 10 327919 6006 50271189
Hyponatraemia 15.36 10.64 490 327439 95649 50181546
Sensitivity to weather change 15.31 10.64 10 327919 5991 50271204
Insulin-requiring type 2 diabetes mellitus 15.20 10.64 8 327921 64 50277131
Respiratory syncytial virus infection 15.20 10.64 7 327922 5095 50272100
Coccydynia 15.18 10.64 28 327901 1200 50275995
Parathyroid gland operation 15.17 10.64 6 327923 22 50277173
Electrocardiogram ST-T change 15.14 10.64 25 327904 980 50276215
Benign gastric neoplasm 15.14 10.64 5 327924 9 50277186
Tympanosclerosis 15.14 10.64 5 327924 9 50277186
Feeling cold 15.11 10.64 70 327859 19461 50257734
Supraventricular extrasystoles 15.09 10.64 58 327871 3886 50273309
Coma scale abnormal 15.08 10.64 6 327923 4765 50272430
Anhedonia 15.05 10.64 24 327905 9500 50267695
Proteinuria 15.01 10.64 56 327873 16541 50260654
Elbow operation 14.99 10.64 13 327916 253 50276942
Intentional dose omission 14.93 10.64 7 327922 5043 50272152
Hypereosinophilic syndrome 14.86 10.64 13 327916 256 50276939
Vascular headache 14.83 10.64 7 327922 43 50277152
Symphysiolysis 14.80 10.64 5 327924 10 50277185
Procedural hypotension 14.74 10.64 26 327903 1076 50276119
Gait inability 14.71 10.64 161 327768 36866 50240329
Full blood count abnormal 14.66 10.64 90 327839 23298 50253897
Breast hyperplasia 14.66 10.64 13 327916 261 50276934
Menstrual disorder 14.65 10.64 5 327924 4365 50272830
Transplant dysfunction 14.63 10.64 6 327923 4678 50272517
Poor personal hygiene 14.63 10.64 14 327915 311 50276884
Dental discomfort 14.60 10.64 15 327914 364 50276831
Bone trimming 14.58 10.64 6 327923 25 50277170
Poliomyelitis 14.57 10.64 7 327922 45 50277150
Hypomagnesaemia 14.57 10.64 89 327840 23067 50254128
Cubital tunnel syndrome 14.57 10.64 12 327917 217 50276978
Ventricular tachycardia 14.56 10.64 53 327876 15768 50261427
Nystagmus 14.55 10.64 9 327920 5552 50271643
Hypersensitivity vasculitis 14.53 10.64 4 327925 4011 50273184
Neoplasm skin 14.51 10.64 25 327904 1015 50276180
Peritonitis bacterial 14.51 10.64 6 327923 4655 50272540
Lip and/or oral cavity cancer 14.44 10.64 14 327915 316 50276879
Tooth dislocation 14.40 10.64 6 327923 26 50277169
Mammoplasty 14.39 10.64 17 327912 484 50276711
Kidney transplant rejection 14.38 10.64 4 327925 3983 50273212
Hallucination, visual 14.32 10.64 57 327872 16525 50260670
Encephalitis 14.31 10.64 16 327913 7364 50269831
Red blood cell sedimentation rate increased 14.28 10.64 269 327660 29147 50248048
Breast operation 14.27 10.64 15 327914 374 50276821
Hepatic function abnormal 14.26 10.64 139 327790 32542 50244653
Retinal operation 14.22 10.64 6 327923 27 50277168
Pyogenic granuloma 14.22 10.64 13 327916 272 50276923
Pulmonary fibrosis 14.21 10.64 230 327699 24207 50252988
Oesophagitis chemical 14.19 10.64 5 327924 12 50277183
Presbyoesophagus 14.19 10.64 5 327924 12 50277183
Piriformis syndrome 14.16 10.64 10 327919 142 50277053
Pregnancy 14.11 10.64 123 327806 29454 50247741
Costochondritis 14.05 10.64 39 327890 2202 50274993
Ovarian cystectomy 14.05 10.64 10 327919 144 50277051
Retinitis 14.04 10.64 35 327894 1852 50275343
Lipase increased 14.00 10.64 21 327908 8520 50268675
Visual impairment 13.99 10.64 336 327593 67939 50209256
Joint irrigation 13.96 10.64 4 327925 3 50277192
Intestinal adhesion lysis 13.96 10.64 4 327925 3 50277192
Ammonia increased 13.96 10.64 5 327924 4236 50272959
Osteodystrophy 13.96 10.64 4 327925 3 50277192
Medication error 13.95 10.64 158 327771 35946 50241249
Motor dysfunction 13.90 10.64 19 327910 8012 50269183
Anticoagulant therapy 13.88 10.64 6 327923 29 50277166
Ketoacidosis 13.87 10.64 4 327925 3891 50273304
Insomnia 13.84 10.64 961 326968 173904 50103291
Pulmonary haemorrhage 13.80 10.64 13 327916 6479 50270716
Large intestinal polypectomy 13.77 10.64 11 327918 190 50277005
Poor venous access 13.72 10.64 29 327900 10311 50266884
Respiration abnormal 13.71 10.64 8 327921 5094 50272101
Swollen tongue 13.69 10.64 119 327810 28511 50248684
Wound dehiscence 13.66 10.64 60 327869 4270 50272925
Anaemia vitamin B12 deficiency 13.65 10.64 14 327915 339 50276856
Hormone replacement therapy 13.64 10.64 5 327924 14 50277181
Vulva cyst 13.64 10.64 5 327924 14 50277181
Lithotripsy 13.64 10.64 5 327924 14 50277181
Sleep apnoea syndrome 13.64 10.64 224 327705 23644 50253551
Sneezing 13.63 10.64 46 327883 13998 50263197
Haematemesis 13.62 10.64 254 327675 27471 50249724
Umbilical hernia repair 13.62 10.64 8 327921 81 50277114
Blepharitis 13.57 10.64 38 327891 2157 50275038
Neurogenic bowel 13.55 10.64 9 327920 115 50277080
Paralysis 13.54 10.64 22 327907 8642 50268553
Pseudarthrosis 13.53 10.64 15 327914 398 50276797
Candida infection 13.49 10.64 93 327836 23430 50253765
Callus formation delayed 13.39 10.64 5 327924 15 50277180
Post procedural hypothyroidism 13.35 10.64 9 327920 118 50277077
Abscess neck 13.33 10.64 18 327911 588 50276607
Acidosis 13.31 10.64 29 327900 10198 50266997
Bone operation 13.26 10.64 11 327918 201 50276994
Vascular insufficiency 13.17 10.64 12 327917 250 50276945
Sebaceous hyperplasia 13.16 10.64 5 327924 16 50277179
Vascular device infection 13.08 10.64 6 327923 4378 50272817
Fatigue 13.06 10.64 4246 323683 703355 49573840
Spider vein 13.01 10.64 12 327917 254 50276941
Catatonia 13.01 10.64 4 327925 3732 50273463
Euphoric mood 12.98 10.64 5 327924 4050 50273145
Breast disorder female 12.98 10.64 8 327921 89 50277106
Osteochondroma 12.97 10.64 4 327925 5 50277190
Galactorrhoea 12.94 10.64 4 327925 3719 50273476
Cystocele repair 12.93 10.64 5 327924 17 50277178
Device intolerance 12.90 10.64 7 327922 60 50277135
Pulmonary thrombosis 12.89 10.64 18 327911 7523 50269672
Brain injury 12.84 10.64 12 327917 6002 50271193
Respiratory tract infection 12.81 10.64 139 327790 31878 50245317
Squamous cell carcinoma 12.78 10.64 90 327839 7649 50269546
Acute pulmonary oedema 12.77 10.64 17 327912 7250 50269945
Injection site nodule 12.76 10.64 3 327926 3345 50273850
Gastrointestinal tract adenoma 12.74 10.64 13 327916 313 50276882
Intestinal ischaemia 12.72 10.64 15 327914 6742 50270453
Rectocele repair 12.71 10.64 5 327924 18 50277177
Jaw clicking 12.71 10.64 5 327924 18 50277177
Left ventricular dysfunction 12.70 10.64 31 327898 10475 50266720
Epstein-Barr virus infection 12.68 10.64 16 327913 6981 50270214
Alanine aminotransferase abnormal 12.67 10.64 57 327872 4099 50273096
Rash pustular 12.62 10.64 14 327915 6467 50270728
Intestinal polyp 12.61 10.64 25 327904 1132 50276063
Urinary tract disorder 12.61 10.64 39 327890 2341 50274854
Medical device pain 12.59 10.64 29 327900 1458 50275737
Blood pressure systolic abnormal 12.58 10.64 19 327910 7687 50269508
Dysplastic naevus syndrome 12.56 10.64 4 327925 6 50277189
Ventricular arrhythmia 12.54 10.64 3 327926 3306 50273889
Dermatitis exfoliative 12.54 10.64 9 327920 5133 50272062
Haemangioma of liver 12.48 10.64 23 327906 985 50276210
Hunger 12.46 10.64 6 327923 4257 50272938
Vaginal dysplasia 12.44 10.64 6 327923 39 50277156
Dacryostenosis acquired 12.39 10.64 16 327913 500 50276695
Personality change 12.36 10.64 11 327918 5634 50271561
Allergy to vaccine 12.36 10.64 10 327919 176 50277019
Blood calcium decreased 12.30 10.64 81 327848 20625 50256570
Diabetic neuropathy 12.29 10.64 51 327878 3540 50273655
Pneumocystis jirovecii pneumonia 12.29 10.64 51 327878 14612 50262583
Ecchymosis 12.26 10.64 110 327819 10059 50267136
Papilloma 12.23 10.64 11 327918 225 50276970
Myofascitis 12.18 10.64 4 327925 7 50277188
Vascular skin disorder 12.18 10.64 4 327925 7 50277188
Modified radical mastectomy 12.18 10.64 4 327925 7 50277188
Oesophagitis haemorrhagic 12.18 10.64 14 327915 387 50276808
Upper-airway cough syndrome 12.18 10.64 96 327833 8454 50268741
Neutrophilia 12.14 10.64 4 327925 3571 50273624
Epidural fibrosis 12.14 10.64 3 327926 0 50277195
Intestinal mucosal tear 12.14 10.64 3 327926 0 50277195
Benign neoplasm of spinal cord 12.14 10.64 3 327926 0 50277195
Alcohol detoxification 12.14 10.64 3 327926 0 50277195
Dental examination abnormal 12.14 10.64 3 327926 0 50277195
Mastoid abscess 12.14 10.64 3 327926 0 50277195
Articular disc disorder 12.14 10.64 3 327926 0 50277195
Deafness traumatic 12.14 10.64 3 327926 0 50277195
Spinal corpectomy 12.14 10.64 3 327926 0 50277195
Traumatic arthropathy 12.14 10.64 3 327926 0 50277195
Arterial bruit 12.14 10.64 3 327926 0 50277195
Arcus lipoides 12.14 10.64 3 327926 0 50277195
Erythroplasia 12.14 10.64 3 327926 0 50277195
Prolapse repair 12.14 10.64 3 327926 0 50277195
Femoral hernia repair 12.14 10.64 3 327926 0 50277195
Vaginal stricture 12.14 10.64 3 327926 0 50277195
Fracture debridement 12.14 10.64 3 327926 0 50277195
Immobile 12.13 10.64 9 327920 5045 50272150
Leriche syndrome 12.12 10.64 5 327924 21 50277174
Lipoma excision 12.12 10.64 5 327924 21 50277174
Chromaturia 12.07 10.64 51 327878 14539 50262656
Oesophageal irritation 12.06 10.64 8 327921 102 50277093
Fibroma 12.05 10.64 19 327910 716 50276479
Peripheral sensory neuropathy 12.02 10.64 15 327914 6576 50270619
Breast necrosis 12.00 10.64 9 327920 141 50277054
Arthrofibrosis 11.94 10.64 5 327924 22 50277173
Pericoronitis 11.94 10.64 5 327924 22 50277173
Gingival operation 11.93 10.64 8 327921 104 50277091
Scab 11.89 10.64 15 327914 6547 50270648
Drug dependence 11.89 10.64 77 327852 19682 50257513
Tongue oedema 11.86 10.64 5 327924 3834 50273361
Pulmonary hypertension 11.85 10.64 149 327780 33268 50243927
Allergy to arthropod sting 11.84 10.64 9 327920 144 50277051
Hypophosphatasia 11.84 10.64 4 327925 8 50277187
Osteoporotic fracture 11.83 10.64 46 327883 3099 50274096
Bundle branch block left 11.83 10.64 75 327854 6155 50271040
Hepatic cyst 11.79 10.64 59 327870 4434 50272761
Tympanic membrane perforation 11.78 10.64 30 327899 1608 50275587
Toxic encephalopathy 11.78 10.64 11 327918 5504 50271691
Laparoscopy 11.76 10.64 5 327924 23 50277172
Lip neoplasm malignant stage unspecified 11.76 10.64 5 327924 23 50277172
Open angle glaucoma 11.73 10.64 11 327918 238 50276957
Laryngeal neoplasm 11.72 10.64 6 327923 45 50277150
Hepatitis acute 11.72 10.64 21 327908 7940 50269255
Peritonitis 11.69 10.64 56 327873 15430 50261765
Chondropathy 11.67 10.64 35 327894 2065 50275130
Pain of skin 11.66 10.64 21 327908 7926 50269269
Incisional hernia 11.66 10.64 27 327902 1362 50275833
Hypokalaemia 11.65 10.64 459 327470 87533 50189662
Metaplasia 11.60 10.64 14 327915 408 50276787
Product preparation error 11.55 10.64 7 327922 4365 50272830
Mineral metabolism disorder 11.53 10.64 4 327925 9 50277186
Salivary gland adenoma 11.53 10.64 4 327925 9 50277186
Tonsillitis 11.51 10.64 9 327920 4914 50272281
Hypovolaemic shock 11.50 10.64 10 327919 5178 50272017
Hypotonia 11.49 10.64 22 327907 8112 50269083
Mixed liver injury 11.48 10.64 4 327925 3447 50273748
Haemoglobin increased 11.47 10.64 3 327926 3112 50274083
Alanine aminotransferase increased 11.46 10.64 462 327467 87897 50189298
Catheter site pain 11.46 10.64 5 327924 3757 50273438
Breast cancer metastatic 11.44 10.64 32 327897 10332 50266863
Cutis laxa 11.44 10.64 9 327920 152 50277043
Nail operation 11.39 10.64 15 327914 478 50276717
Eyelid oedema 11.38 10.64 28 327901 9438 50267757
Immune thrombocytopenia 11.38 10.64 26 327903 8991 50268204
Blood prolactin increased 11.38 10.64 3 327926 3096 50274099
Loss of employment 11.36 10.64 29 327900 1557 50275638
Lentigo 11.36 10.64 11 327918 248 50276947
Stomatitis necrotising 11.31 10.64 8 327921 114 50277081
Lip swelling 11.31 10.64 104 327825 24632 50252563
Pharyngo-oesophageal diverticulum 11.24 10.64 4 327925 10 50277185
Dental care 11.21 10.64 21 327908 911 50276284
Bronchial secretion retention 11.19 10.64 28 327901 1485 50275710
Focal segmental glomerulosclerosis 11.19 10.64 26 327903 1315 50275880
Initial insomnia 11.16 10.64 10 327919 5105 50272090
Gastric ulcer haemorrhage 11.15 10.64 58 327871 4426 50272769
Jaundice cholestatic 11.15 10.64 10 327919 5101 50272094
Breast cancer in situ 11.13 10.64 27 327902 1404 50275791
Gingival atrophy 11.12 10.64 5 327924 27 50277168
Device leakage 11.12 10.64 13 327916 5865 50271330
Acute generalised exanthematous pustulosis 11.10 10.64 26 327903 8912 50268283
Calcinosis 11.07 10.64 32 327897 1850 50275345
Peroneal nerve palsy 11.07 10.64 56 327873 4227 50272968
Drug specific antibody present 11.04 10.64 4 327925 3364 50273831
Vitreous detachment 11.03 10.64 31 327898 1763 50275432
Gastrointestinal infection 11.02 10.64 18 327911 7056 50270139
Conjunctivitis allergic 11.01 10.64 18 327911 700 50276495
Antinuclear antibody positive 10.99 10.64 74 327855 6198 50270997
Pedal pulse decreased 10.97 10.64 5 327924 28 50277167
Pulse absent 10.97 10.64 9 327920 4797 50272398
Borderline glaucoma 10.97 10.64 4 327925 11 50277184
Immune system disorder 10.94 10.64 23 327906 8194 50269001
Procedural nausea 10.93 10.64 18 327911 704 50276491
Influenza B virus test positive 10.91 10.64 11 327918 261 50276934
Hypertrophy 10.90 10.64 13 327916 374 50276821
Device breakage 10.87 10.64 102 327827 9445 50267750
Blood potassium increased 10.86 10.64 62 327867 16336 50260859
Infusion site haemorrhage 10.86 10.64 3 327926 3001 50274194
Wisdom teeth removal 10.86 10.64 14 327915 437 50276758
Gastrointestinal tract mucosal pigmentation 10.85 10.64 16 327913 568 50276627
Urinary retention postoperative 10.81 10.64 6 327923 54 50277141
Joint stiffness 10.80 10.64 135 327794 30173 50247022
Soft tissue inflammation 10.77 10.64 11 327918 265 50276930
Generalised anxiety disorder 10.75 10.64 31 327898 1789 50275406
Balance disorder 10.74 10.64 362 327567 70228 50206967
Lordosis 10.74 10.64 11 327918 266 50276929
Urine calcium decreased 10.72 10.64 4 327925 12 50277183
Renal cyst haemorrhage 10.72 10.64 6 327923 55 50277140
Hypervitaminosis 10.69 10.64 5 327924 30 50277165
IVth nerve paralysis 10.69 10.64 5 327924 30 50277165
Hypertransaminasaemia 10.68 10.64 5 327924 3606 50273589
Family stress 10.67 10.64 16 327913 577 50276618

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis 376.23 11.00 223 35615 13296 29525393
Osteonecrosis of jaw 316.07 11.00 215 35623 16295 29522394
Femur fracture 269.86 11.00 143 35695 6848 29531841
Atypical femur fracture 173.59 11.00 45 35793 246 29538443
Low turnover osteopathy 168.77 11.00 36 35802 65 29538624
Impaired healing 125.34 11.00 115 35723 13443 29525246
Osteomyelitis 124.25 11.00 115 35723 13594 29525095
Dental caries 108.56 11.00 66 35772 4114 29534575
Toxicity to various agents 106.11 11.00 39 35799 173622 29365067
Intramedullary rod insertion 105.59 11.00 20 35818 11 29538678
Bone density decreased 99.48 11.00 46 35792 1634 29537055
Open reduction of fracture 98.72 11.00 23 35815 73 29538616
Atypical fracture 97.35 11.00 24 35814 103 29538586
Osteoporosis 96.93 11.00 90 35748 10679 29528010
Completed suicide 92.28 11.00 4 35834 90242 29448447
Stress fracture 81.35 11.00 32 35806 756 29537933
Drug abuse 77.10 11.00 5 35833 79878 29458811
Tooth disorder 69.55 11.00 71 35767 9458 29529231
Osteoarthritis 69.21 11.00 97 35741 18006 29520683
Febrile neutropenia 68.84 11.00 25 35813 112215 29426474
Death 65.09 11.00 206 35632 341878 29196811
Periodontal disease 62.66 11.00 26 35812 708 29537981
Tibia fracture 58.92 11.00 30 35808 1320 29537369
Hypophosphataemic osteomalacia 58.59 11.00 16 35822 110 29538579
Osteopenia 58.49 11.00 45 35793 4123 29534566
Tooth fracture 57.74 11.00 40 35798 3116 29535573
Rheumatoid arthritis 55.18 11.00 121 35717 32031 29506658
Tooth loss 54.50 11.00 41 35797 3633 29535056
Exostosis of jaw 53.18 11.00 14 35824 82 29538607
Drug ineffective 52.12 11.00 245 35593 362925 29175764
Jaw disorder 50.30 11.00 31 35807 1979 29536710
Hypercalciuria 50.18 11.00 17 35821 258 29538431
Gastrooesophageal reflux disease 47.90 11.00 113 35725 31383 29507306
Craniotabes 47.48 11.00 9 35829 5 29538684
Blood parathyroid hormone decreased 47.04 11.00 22 35816 802 29537887
Internal fixation of fracture 46.28 11.00 11 35827 39 29538650
Bone fissure 45.88 11.00 10 35828 21 29538668
Exposed bone in jaw 45.23 11.00 26 35812 1460 29537229
Fracture nonunion 44.64 11.00 14 35824 164 29538525
Jaw fracture 44.35 11.00 22 35816 915 29537774
Neutropenia 44.06 11.00 57 35781 131654 29407035
Spinal compression fracture 43.73 11.00 45 35793 6049 29532640
Fall 42.64 11.00 363 35475 176815 29361874
Arthralgia 42.42 11.00 302 35536 139315 29399374
Anaemia postoperative 41.59 11.00 17 35821 445 29538244
Spinal fracture 41.40 11.00 45 35793 6441 29532248
Exostosis 40.28 11.00 34 35804 3555 29535134
Asthma 39.60 11.00 110 35728 33739 29504950
Blood immunoglobulin E increased 38.76 11.00 26 35812 1921 29536768
Cataract 38.14 11.00 84 35754 22294 29516395
Tooth abscess 37.75 11.00 38 35800 4976 29533713
Lumbar vertebral fracture 35.89 11.00 24 35814 1764 29536925
Oral infection 35.50 11.00 24 35814 1796 29536893
Pain in jaw 35.34 11.00 56 35782 11585 29527104
Hyperlipidaemia 34.74 11.00 58 35780 12532 29526157
Sleep apnoea syndrome 34.56 11.00 70 35768 17529 29521160
Hypophosphatasia 34.43 11.00 8 35830 25 29538664
Thrombocytopenia 34.17 11.00 70 35768 134753 29403936
Spinal osteoarthritis 33.61 11.00 40 35798 6316 29532373
Dental fistula 33.40 11.00 10 35828 99 29538590
Foot fracture 33.29 11.00 32 35806 3963 29534726
Resorption bone increased 33.16 11.00 11 35827 156 29538533
Temporomandibular joint syndrome 33.09 11.00 17 35821 762 29537927
Medical device removal 31.97 11.00 10 35828 116 29538573
Periodontitis 30.85 11.00 22 35816 1795 29536894
Device breakage 29.45 11.00 21 35817 1713 29536976
Rib fracture 29.14 11.00 54 35784 12664 29526025
Bone disorder 28.31 11.00 35 35803 5748 29532941
Nerve degeneration 28.00 11.00 10 35828 179 29538510
Fibula fracture 27.82 11.00 15 35823 743 29537946
Nausea 27.82 11.00 221 35617 289034 29249655
Hip fracture 27.18 11.00 47 35791 10445 29528244
Tooth extraction 26.97 11.00 29 35809 4100 29534589
Leukopenia 26.64 11.00 17 35821 55186 29483503
Alveolar osteitis 26.30 11.00 8 35830 84 29538605
Thoracic vertebral fracture 26.24 11.00 18 35820 1380 29537309
Red blood cell sedimentation rate 26.20 11.00 13 35825 541 29538148
Intervertebral disc degeneration 26.00 11.00 32 35806 5232 29533457
Periprosthetic fracture 25.85 11.00 9 35829 149 29538540
Bone metabolism disorder 25.39 11.00 10 35828 237 29538452
Hypotension 24.97 11.00 136 35702 194218 29344471
Gingival disorder 24.95 11.00 17 35821 1289 29537400
Dental necrosis 24.88 11.00 6 35832 23 29538666
Nasal polyps 24.60 11.00 19 35819 1750 29536939
Pyrexia 24.41 11.00 227 35611 287395 29251294
Acetabulum fracture 24.39 11.00 10 35828 264 29538425
Granuloma skin 24.28 11.00 13 35825 635 29538054
Scoliosis 24.20 11.00 21 35817 2279 29536410
Abscess jaw 23.65 11.00 13 35825 669 29538020
Gingivitis 23.45 11.00 23 35815 2919 29535770
Disease progression 22.96 11.00 40 35798 81876 29456813
Vomiting 22.85 11.00 157 35681 212103 29326586
Back pain 22.69 11.00 206 35632 102078 29436611
Infusion related reaction 22.45 11.00 109 35729 43777 29494912
Renal mass 22.43 11.00 17 35821 1523 29537166
Oesophageal ulcer 22.31 11.00 23 35815 3097 29535592
Coma 22.18 11.00 10 35828 39440 29499249
Ankle fracture 21.98 11.00 24 35814 3452 29535237
Basal cell carcinoma 21.82 11.00 57 35781 16853 29521836
Lumbar spinal stenosis 21.80 11.00 20 35818 2335 29536354
Bursitis 21.68 11.00 28 35810 4804 29533885
Gastritis 21.42 11.00 62 35776 19455 29519234
Arthropathy 21.32 11.00 66 35772 21488 29517201
Renal cyst 21.24 11.00 36 35802 7871 29530818
Diverticulitis 21.16 11.00 58 35780 17646 29521043
Benign prostatic hyperplasia 21.14 11.00 45 35793 11665 29527024
Fracture delayed union 20.96 11.00 6 35832 50 29538639
Bone loss 20.83 11.00 11 35827 522 29538167
Pain 20.78 11.00 307 35531 171125 29367564
Intentional product misuse 20.75 11.00 8 35830 34653 29504036
Kyphosis 20.24 11.00 14 35824 1088 29537601
Suicide attempt 20.21 11.00 8 35830 34102 29504587
Off label use 20.04 11.00 251 35587 300549 29238140
Pathological fracture 19.96 11.00 24 35814 3831 29534858
Lactic acidosis 19.81 11.00 6 35832 30241 29508448
Acute kidney injury 19.73 11.00 216 35622 265051 29273638
Chronic obstructive pulmonary disease 19.72 11.00 100 35738 40855 29497834
Rhabdomyolysis 19.61 11.00 27 35811 60781 29477908
Rheumatoid nodule 19.60 11.00 18 35820 2104 29536585
Pulmonary fibrosis 19.58 11.00 52 35786 15530 29523159
Nasal septum deviation 19.56 11.00 13 35825 946 29537743
Diarrhoea 19.51 11.00 285 35553 332413 29206276
Extraskeletal ossification 19.18 11.00 5 35833 28 29538661
Sequestrectomy 19.14 11.00 8 35830 222 29538467
Skin ulcer 18.93 11.00 58 35780 18782 29519907
Rhinitis 18.85 11.00 26 35812 4752 29533937
Corneal abrasion 18.84 11.00 8 35830 231 29538458
Cardiac arrest 18.78 11.00 48 35790 85543 29453146
Chronic sinusitis 18.77 11.00 16 35822 1695 29536994
Oral cavity fistula 18.60 11.00 7 35831 146 29538543
Tendonitis 18.49 11.00 34 35804 7927 29530762
Hiatus hernia 18.48 11.00 31 35807 6721 29531968
Calcium deficiency 18.47 11.00 7 35831 149 29538540
Device failure 18.43 11.00 17 35821 1999 29536690
Obstructive airways disorder 18.37 11.00 41 35797 10975 29527714
Pelvic cyst 18.23 11.00 5 35833 35 29538654
Central nervous system mass 17.96 11.00 6 35832 87 29538602
Mouth swelling 17.83 11.00 15 35823 1561 29537128
Wall motion score index abnormal 17.36 11.00 6 35832 97 29538592
Pneumonectomy 17.23 11.00 5 35833 44 29538645
Dental prosthesis placement 17.15 11.00 3 35835 0 29538689
Poor dental condition 17.13 11.00 7 35831 183 29538506
Oral disorder 17.05 11.00 22 35816 3771 29534918
Bone abscess 17.03 11.00 7 35831 186 29538503
Pelvic fracture 16.96 11.00 17 35821 2214 29536475
Polymyalgia rheumatica 16.83 11.00 13 35825 1198 29537491
Joint dislocation 16.75 11.00 20 35818 3169 29535520
Panniculitis 16.73 11.00 13 35825 1208 29537481
White blood cell count decreased 16.61 11.00 49 35789 83313 29455376
Clumsiness 16.35 11.00 14 35824 1492 29537197
Atopy 16.04 11.00 6 35832 123 29538566
Compression fracture 16.03 11.00 18 35820 2670 29536019
Overdose 15.84 11.00 47 35791 79772 29458917
Loose tooth 15.81 11.00 12 35826 1077 29537612
Osteomalacia 15.78 11.00 11 35827 865 29537824
Restrictive pulmonary disease 15.74 11.00 12 35826 1084 29537605
Carpal tunnel syndrome 15.65 11.00 22 35816 4092 29534597
Liver function test abnormal 15.64 11.00 73 35765 28845 29509844
Femoral neck fracture 15.42 11.00 18 35820 2785 29535904
Bone infarction 15.39 11.00 7 35831 239 29538450
Renal neoplasm 15.39 11.00 12 35826 1121 29537568
Cardiac septal defect 15.31 11.00 7 35831 242 29538447
Airway remodelling 15.28 11.00 6 35832 141 29538548
Idiopathic pulmonary fibrosis 15.23 11.00 19 35819 3149 29535540
Systemic lupus erythematosus 14.99 11.00 17 35821 2549 29536140
Enterocolitis bacterial 14.75 11.00 7 35831 264 29538425
Myelomalacia 14.63 11.00 5 35833 78 29538611
Osteitis 14.63 11.00 13 35825 1456 29537233
Dermal sinus 14.61 11.00 3 35835 4 29538685
Sinus polyp 14.61 11.00 6 35832 159 29538530
Vertebroplasty 14.46 11.00 4 35834 29 29538660
Groin pain 14.45 11.00 23 35815 4775 29533914
Rhinitis allergic 14.39 11.00 17 35821 2663 29536026
Penile erythema 14.37 11.00 6 35832 166 29538523
Cellulitis 14.37 11.00 100 35738 45740 29492949
Foetal exposure during pregnancy 14.30 11.00 12 35826 33855 29504834
Mycobacterium chelonae infection 14.26 11.00 9 35829 599 29538090
Fracture 14.24 11.00 26 35812 6027 29532662
Oesophagitis 14.18 11.00 39 35799 11884 29526805
Nasopharyngitis 14.16 11.00 122 35716 59543 29479146
Intervertebral disc protrusion 14.15 11.00 32 35806 8638 29530051
Arthritis 14.15 11.00 64 35774 24955 29513734
Migraine 14.14 11.00 40 35798 12390 29526299
Fistula discharge 14.12 11.00 8 35830 437 29538252
Actinic keratosis 14.04 11.00 20 35818 3766 29534923
Limb asymmetry 13.92 11.00 5 35833 91 29538598
COVID-19 13.74 11.00 14 35824 36000 29502689
Animal scratch 13.67 11.00 6 35832 188 29538501
Bladder pain 13.58 11.00 8 35830 470 29538219
Acute on chronic liver failure 13.48 11.00 5 35833 100 29538589
Lenticular opacities 13.47 11.00 6 35832 195 29538494
Lung neoplasm 13.34 11.00 21 35817 4319 29534370
Erythrasma 13.33 11.00 4 35834 40 29538649
Eosinophilic granulomatosis with polyangiitis 13.28 11.00 12 35826 1374 29537315
Mobility decreased 13.16 11.00 64 35774 25716 29512973
Lower limb fracture 13.11 11.00 19 35819 3633 29535056
Loose body in joint 13.06 11.00 4 35834 43 29538646
Rectal haemorrhage 13.05 11.00 79 35759 34470 29504219
Urinary tract discomfort 13.00 11.00 5 35833 111 29538578
Wound complication 12.93 11.00 14 35824 1995 29536694
Herpes zoster 12.84 11.00 71 35767 29981 29508708
Amino acid level increased 12.81 11.00 7 35831 356 29538333
JC virus CSF test positive 12.64 11.00 5 35833 120 29538569
Ulcer 12.62 11.00 27 35811 7024 29531665
Oesophageal carcinoma 12.61 11.00 21 35817 4526 29534163
Renal failure 12.60 11.00 88 35750 118511 29420178
Langerhans' cell histiocytosis 12.59 11.00 4 35834 49 29538640
Abdominal rigidity 12.53 11.00 11 35827 1213 29537476
Bronchitis 12.49 11.00 82 35756 36786 29501903
Pulpitis dental 12.43 11.00 7 35831 378 29538311
Laryngeal ulceration 12.37 11.00 5 35833 127 29538562
Jaw cyst 12.34 11.00 3 35835 12 29538677
Fracture malunion 12.34 11.00 3 35835 12 29538677
Aortic arteriosclerosis 12.25 11.00 19 35819 3857 29534832
Reversible airways obstruction 12.20 11.00 6 35832 245 29538444
Oral pustule 12.20 11.00 6 35832 245 29538444
Pulmonary vasculitis 12.19 11.00 5 35833 132 29538557
Microangiopathy 12.10 11.00 9 35829 784 29537905
Gastric ulcer 12.05 11.00 41 35797 14020 29524669
Dental plaque 11.96 11.00 3 35835 14 29538675
Sinus pain 11.90 11.00 8 35830 593 29538096
Spinal stenosis 11.90 11.00 20 35818 4343 29534346
Fracture displacement 11.73 11.00 4 35834 62 29538627
Phlebosclerosis 11.72 11.00 5 35833 146 29538543
Body mass index increased 11.71 11.00 9 35829 823 29537866
Musculoskeletal disorder 11.69 11.00 22 35816 5218 29533471
Upper gastrointestinal haemorrhage 11.61 11.00 55 35783 21859 29516830
Suicidal ideation 11.61 11.00 15 35823 34701 29503988
Tooth impacted 11.56 11.00 4 35834 65 29538624
Spinal fusion surgery 11.55 11.00 9 35829 840 29537849
Bronchiectasis 11.53 11.00 25 35813 6560 29532129
Eyelid disorder 11.48 11.00 7 35831 438 29538251
Tunnel vision 11.48 11.00 7 35831 438 29538251
Peripheral sensorimotor neuropathy 11.40 11.00 11 35827 1368 29537321
Iron deficiency anaemia 11.39 11.00 30 35808 8912 29529777
Eosinophilic myocarditis 11.34 11.00 7 35831 448 29538241
Pruritus 11.31 11.00 89 35749 116760 29421929
Rotator cuff repair 11.26 11.00 6 35832 290 29538399
Eosinophilic pneumonia chronic 11.24 11.00 5 35833 162 29538527
Lichen myxoedematosus 11.20 11.00 3 35835 19 29538670
Tooth discolouration 11.19 11.00 6 35832 294 29538395
Periarthritis 11.13 11.00 9 35829 886 29537803
Eosinophilic pustular folliculitis 11.13 11.00 4 35834 73 29538616
Diverticulum 11.05 11.00 24 35814 6308 29532381
Trismus 11.04 11.00 14 35824 2359 29536330
Hypercholesterolaemia 11.03 11.00 26 35812 7212 29531477
Malignant neoplasm progression 11.01 11.00 49 35789 73810 29464879

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 4048.09 10.58 2185 252087 31950 64212510
Osteonecrosis of jaw 2880.97 10.58 1852 252420 37973 64206487
Osteonecrosis 2595.25 10.58 1530 252742 26699 64217761
Atypical femur fracture 1565.41 10.58 617 253655 4081 64240379
Low turnover osteopathy 1341.75 10.58 434 253838 1439 64243021
Pemphigus 1258.76 10.58 1368 252904 59333 64185127
Osteomyelitis 1188.85 10.58 936 253336 26651 64217809
Stress fracture 1168.59 10.58 528 253744 5096 64239364
Systemic lupus erythematosus 1141.14 10.58 1467 252805 76145 64168315
Impaired healing 1076.58 10.58 1259 253013 59214 64185246
Dental caries 1075.82 10.58 617 253655 10183 64234277
Glossodynia 1071.20 10.58 1298 252974 63398 64181062
Hand deformity 982.06 10.58 1224 253048 61547 64182913
Arthropathy 971.51 10.58 1724 252548 119243 64125217
Tooth disorder 894.65 10.58 727 253545 21675 64222785
Toxicity to various agents 876.53 10.58 183 254089 363330 63881130
Jaw disorder 796.19 10.58 381 253891 4236 64240224
Anti-cyclic citrullinated peptide antibody positive 769.60 10.58 963 253309 48599 64195861
Pericarditis 768.01 10.58 1083 253189 61433 64183027
Wound 741.37 10.58 1186 253086 75291 64169169
Oral infection 739.01 10.58 366 253906 4411 64240049
Completed suicide 710.05 10.58 44 254228 224370 64020090
Osteoarthritis 679.08 10.58 1029 253243 62307 64182153
Death 671.40 10.58 552 253720 482153 63762307
Abdominal discomfort 619.35 10.58 1849 252423 180473 64063987
Alopecia 592.02 10.58 1711 252561 163979 64080481
Fracture nonunion 590.17 10.58 221 254051 1245 64243215
Synovitis 569.37 10.58 1227 253045 97863 64146597
Duodenal ulcer perforation 545.79 10.58 678 253594 33947 64210513
Tooth fracture 539.15 10.58 387 253885 9540 64234920
Exostosis of jaw 535.95 10.58 195 254077 999 64243461
Bone disorder 522.48 10.58 472 253800 16287 64228173
Discomfort 520.14 10.58 1049 253223 79829 64164631
Temporomandibular joint syndrome 516.44 10.58 257 254015 3131 64241329
Acute kidney injury 513.52 10.58 610 253662 448630 63795830
Helicobacter infection 503.06 10.58 686 253586 37676 64206784
Swelling 469.35 10.58 1544 252728 158674 64085786
Febrile neutropenia 458.93 10.58 91 254181 187566 64056894
Hyperlipidaemia 438.28 10.58 496 253776 22480 64221980
Neutropenia 432.16 10.58 202 254070 239422 64005038
Drug abuse 430.69 10.58 22 254250 132352 64112108
Gingival disorder 429.48 10.58 226 254046 3118 64241342
Off label use 408.12 10.58 1216 253056 631590 63612870
Gastrooesophageal reflux disease 404.51 10.58 964 253308 82179 64162281
Infusion related reaction 402.06 10.58 1493 252779 162974 64081486
Bone density decreased 393.10 10.58 321 253951 9631 64234829
Pathological fracture 393.10 10.58 308 253964 8697 64235763
Exostosis 392.15 10.58 340 253932 11098 64233362
Periodontal disease 390.54 10.58 171 254101 1520 64242940
Tooth loss 377.51 10.58 260 254012 5987 64238473
Contraindicated product administered 370.87 10.58 1099 253173 106730 64137730
Irritable bowel syndrome 365.28 10.58 582 253690 36787 64207673
Hypotension 360.40 10.58 592 253680 380382 63864078
Intervertebral disc degeneration 355.90 10.58 342 253930 12778 64231682
Anaemia postoperative 355.55 10.58 162 254110 1596 64242864
Drug intolerance 352.54 10.58 1572 252700 186420 64058040
Rheumatoid factor positive 344.06 10.58 546 253726 34392 64210068
Drug interaction 343.99 10.58 561 253711 361522 63882938
Adverse event 341.51 10.58 582 253690 38907 64205553
Spinal osteoarthritis 341.13 10.58 348 253924 13993 64230467
Bone loss 330.04 10.58 164 254108 1991 64242469
Resorption bone increased 318.96 10.58 133 254139 1035 64243425
Muscle injury 315.62 10.58 452 253820 25985 64218475
Thrombocytopenia 311.54 10.58 255 254017 223546 64020914
Foot fracture 311.20 10.58 371 253901 17786 64226674
Intentional overdose 309.13 10.58 10 254262 89934 64154526
Vomiting 308.07 10.58 1127 253145 549990 63694470
Fracture delayed union 306.78 10.58 152 254120 1833 64242627
Jaw fracture 304.68 10.58 169 254103 2605 64241855
Tooth abscess 304.60 10.58 322 253950 13504 64230956
Blood parathyroid hormone decreased 302.37 10.58 243 254029 7123 64237337
Bursitis 291.96 10.58 391 253881 21094 64223366
Hepatic enzyme increased 288.99 10.58 1145 253127 128798 64115662
Diarrhoea 281.77 10.58 1685 252587 721019 63523441
Adverse drug reaction 277.15 10.58 577 253695 44887 64199573
Oral disorder 275.58 10.58 250 254022 8671 64235789
Nausea 274.85 10.58 1894 252378 783906 63460554
Loose tooth 274.57 10.58 161 254111 2773 64241687
Granuloma skin 272.17 10.58 211 254061 5863 64238597
Cardiac arrest 271.29 10.58 134 254138 153930 64090530
Blood cholesterol increased 270.38 10.58 605 253667 49461 64194999
Hypersensitivity 269.07 10.58 1503 252769 194949 64049511
Osteopenia 263.81 10.58 316 253956 15224 64229236
Folliculitis 263.64 10.58 446 253826 29631 64214829
Gingivitis 263.22 10.58 228 254044 7431 64237029
Maternal exposure during pregnancy 260.16 10.58 901 253371 94983 64149477
Rheumatoid nodule 259.99 10.58 284 253988 12367 64232093
Arthralgia 259.36 10.58 2773 251499 439487 63804973
Therapeutic product effect decreased 254.51 10.58 1014 253258 114337 64130123
Diverticulum 250.13 10.58 284 253988 12914 64231546
Atypical fracture 249.96 10.58 95 254177 561 64243899
Spondylolisthesis 247.55 10.58 148 254124 2646 64241814
Panniculitis 245.65 10.58 234 254038 8645 64235815
Sleep disorder due to general medical condition, insomnia type 245.60 10.58 401 253871 25869 64218591
Disease progression 245.29 10.58 126 254146 141554 64102906
Fall 245.02 10.58 2615 251657 414211 63830249
Periodontitis 244.03 10.58 170 254102 3989 64240471
Hip fracture 243.06 10.58 406 253866 26693 64217767
Joint swelling 234.73 10.58 1553 252719 213829 64030631
Pyrexia 232.16 10.58 1275 252997 557369 63687091
Edentulous 224.88 10.58 69 254203 182 64244278
Device failure 223.55 10.58 183 254089 5509 64238951
Hypercholesterolaemia 221.58 10.58 288 253984 15085 64229375
Oral cavity fistula 218.94 10.58 87 254185 589 64243871
Uterine disorder 214.21 10.58 116 254156 1701 64242759
Cataract 212.09 10.58 559 253713 50703 64193757
Vitamin D deficiency 202.16 10.58 240 254032 11452 64233008
Product dose omission issue 201.77 10.58 284 253988 194463 64049997
Scoliosis 200.86 10.58 177 254095 5905 64238555
Cardio-respiratory arrest 199.96 10.58 69 254203 98324 64146136
Suicide attempt 199.58 10.58 23 254249 70984 64173476
Blister 196.74 10.58 734 253538 80233 64164227
Basal cell carcinoma 195.73 10.58 398 253874 30440 64214020
Rib fracture 193.10 10.58 343 253929 23695 64220765
Tonsillar disorder 192.27 10.58 89 254183 912 64243548
Malignant neoplasm progression 191.48 10.58 103 254169 112768 64131692
Fistula discharge 189.25 10.58 88 254184 912 64243548
Rotator cuff syndrome 187.40 10.58 235 254037 11872 64232588
Spinal compression fracture 187.28 10.58 260 254012 14515 64229945
Ulcer 187.20 10.58 330 253942 22660 64221800
Pelvic fracture 186.23 10.58 219 254053 10344 64234116
Exposed bone in jaw 184.90 10.58 134 254138 3353 64241107
Osteitis 180.34 10.58 134 254138 3488 64240972
Hip arthroplasty 179.73 10.58 311 253961 21040 64223420
Osteoporosis 178.29 10.58 463 253809 41617 64202843
Fibrocystic breast disease 176.08 10.58 72 254200 530 64243930
Fracture displacement 174.62 10.58 88 254184 1103 64243357
Tibia fracture 172.73 10.58 146 254126 4599 64239861
Abscess jaw 172.63 10.58 97 254175 1535 64242925
White blood cell count decreased 168.67 10.58 225 254047 157612 64086848
Hiatus hernia 168.39 10.58 291 253981 19666 64224794
Cerumen impaction 167.93 10.58 85 254187 1076 64243384
Pain in jaw 167.13 10.58 443 253829 40312 64204148
Sepsis 163.92 10.58 421 253851 229920 64014540
Breast disorder 161.79 10.58 94 254178 1590 64242870
Intramedullary rod insertion 160.86 10.58 49 254223 125 64244335
Platelet count decreased 160.70 10.58 258 254014 167453 64077007
Dental fistula 159.98 10.58 64 254208 442 64244018
Knee arthroplasty 156.79 10.58 336 253936 26663 64217797
Lactic acidosis 155.96 10.58 27 254245 61383 64183077
COVID-19 150.16 10.58 36 254236 65104 64179356
Muscle strain 149.66 10.58 173 254099 8021 64236439
Haemorrhoids 149.04 10.58 307 253965 23694 64220766
Intentional product misuse 148.09 10.58 50 254222 72245 64172215
Pneumonia 147.42 10.58 1453 252819 558123 63686337
Ulna fracture 147.22 10.58 74 254198 922 64243538
Abscess 145.56 10.58 268 254004 19036 64225424
Large intestine polyp 145.35 10.58 196 254076 10641 64233819
Skin necrosis 145.28 10.58 227 254045 14102 64230358
Fistula 144.01 10.58 185 254087 9576 64234884
Tendonitis 143.50 10.58 274 253998 20008 64224452
Multiple organ dysfunction syndrome 141.67 10.58 115 254157 101298 64143162
Seizure 141.59 10.58 277 253995 166615 64077845
Lumbar spinal stenosis 141.06 10.58 129 254143 4521 64239939
Gastrointestinal disorder 140.83 10.58 713 253559 88996 64155464
Pain 140.66 10.58 3007 251265 550504 63693956
Dental necrosis 138.66 10.58 43 254229 119 64244341
Spinal fracture 138.28 10.58 229 254043 14945 64229515
Renal failure 137.94 10.58 321 253951 181367 64063093
Stress urinary incontinence 137.31 10.58 83 254189 1515 64242945
Asthenia 136.80 10.58 1057 253215 426987 63817473
Pancytopenia 136.77 10.58 221 254051 143088 64101372
Synovial cyst 136.22 10.58 160 254112 7547 64236913
Radius fracture 134.86 10.58 107 254165 3077 64241383
Overdose 134.36 10.58 266 254006 159300 64085160
Hyperaesthesia teeth 134.12 10.58 81 254191 1476 64242984
Rheumatic fever 132.20 10.58 173 254099 9121 64235339
Contusion 130.85 10.58 833 253439 113132 64131328
Abscess oral 129.61 10.58 72 254200 1113 64243347
Kyphosis 129.26 10.58 93 254179 2300 64242160
Respiratory arrest 128.77 10.58 26 254246 52959 64191501
Meniscus injury 125.56 10.58 135 254137 5772 64238688
Hyperhidrosis 125.55 10.58 186 254086 124734 64119726
Lumbar radiculopathy 125.12 10.58 81 254191 1676 64242784
Periprosthetic fracture 124.85 10.58 56 254216 530 64243930
Wrist fracture 123.79 10.58 174 254098 9827 64234633
Appendix disorder 121.29 10.58 76 254196 1483 64242977
Leukopenia 120.11 10.58 133 254139 101109 64143351
Electrocardiogram QT prolonged 120.09 10.58 83 254189 79365 64165095
Respiratory failure 118.97 10.58 289 253983 160894 64083566
Ligament sprain 118.59 10.58 178 254094 10674 64233786
Hypercalcaemia 118.32 10.58 331 253941 31085 64213375
Swollen joint count increased 117.02 10.58 148 254124 7541 64236919
Foot deformity 116.81 10.58 223 254049 16281 64228179
Fibula fracture 116.50 10.58 97 254175 2991 64241469
Intervertebral disc protrusion 114.63 10.58 249 254023 19942 64224518
Gingival bleeding 112.98 10.58 207 254065 14647 64229813
Metabolic acidosis 111.47 10.58 71 254201 70887 64173573
Septic shock 110.89 10.58 152 254120 105285 64139175
Dyspnoea 110.60 10.58 2083 252189 716591 63527869
Injection site pain 109.90 10.58 168 254104 111240 64133220
Rhinitis allergic 109.71 10.58 147 254125 7931 64236529
Neutrophil count decreased 108.48 10.58 87 254185 77109 64167351
Drug reaction with eosinophilia and systemic symptoms 108.45 10.58 39 254233 54178 64190282
Drug tolerance decreased 106.98 10.58 135 254137 6863 64237597
Pulpitis dental 106.25 10.58 60 254212 959 64243501
Hyperkalaemia 106.14 10.58 146 254126 100983 64143477
Rhabdomyolysis 106.08 10.58 123 254149 91603 64152857
Skin ulcer 105.40 10.58 397 253875 43577 64200883
Alveolar osteitis 105.06 10.58 45 254227 377 64244083
Mucosal inflammation 104.82 10.58 58 254214 62526 64181934
Agitation 103.82 10.58 117 254155 88250 64156210
Carpal tunnel syndrome 103.67 10.58 207 254065 15621 64228839
Sedation 103.61 10.58 19 254253 41443 64203017
Tachycardia 103.58 10.58 277 253995 149302 64095158
Depressed level of consciousness 103.34 10.58 101 254171 81335 64163125
Oesophagitis 103.16 10.58 249 254023 21381 64223079
Cystocele 102.82 10.58 52 254220 657 64243803
Jaw operation 102.33 10.58 53 254219 706 64243754
Atrophic vulvovaginitis 102.22 10.58 62 254210 1139 64243321
Patellofemoral pain syndrome 101.99 10.58 45 254227 408 64244052
Anaemia 101.75 10.58 978 253294 377702 63866758
Bradycardia 101.29 10.58 195 254077 118024 64126436
Encephalopathy 100.72 10.58 53 254219 58766 64185694
Fractured sacrum 100.15 10.58 66 254206 1409 64243051
Bone lesion 99.82 10.58 112 254160 5025 64239435
Loss of consciousness 99.56 10.58 279 253993 148086 64096374
Osteoradionecrosis 97.81 10.58 30 254242 79 64244381
Blood creatinine increased 97.42 10.58 247 254025 135535 64108925
Tooth extraction 97.19 10.58 152 254120 9449 64235011
Arthritis 96.41 10.58 613 253659 83201 64161259
Toothache 95.36 10.58 212 254060 17247 64227213
Joint effusion 94.06 10.58 181 254091 13292 64231168
Pulmonary embolism 92.55 10.58 283 253989 146073 64098387
Haemoglobin decreased 92.20 10.58 425 253847 194638 64049822
Femoral neck fracture 90.95 10.58 140 254132 8584 64235876
Radiculopathy 90.74 10.58 112 254160 5566 64238894
Hepatic failure 90.39 10.58 53 254219 55341 64189119
Nasal septum deviation 90.18 10.58 63 254209 1485 64242975
Drug resistance 90.08 10.58 15 254257 35087 64209373
Sinusitis 89.36 10.58 924 253348 145004 64099456
Sopor 87.50 10.58 8 254264 29653 64214807
Osteomyelitis chronic 87.41 10.58 44 254228 550 64243910
Lower limb fracture 87.34 10.58 176 254096 13369 64231091
Calcium deficiency 86.68 10.58 47 254225 691 64243769
Mitral valve prolapse 86.46 10.58 67 254205 1860 64242600
Gingival recession 86.39 10.58 54 254218 1049 64243411
Actinomycosis 86.33 10.58 51 254221 891 64243569
Ill-defined disorder 85.88 10.58 373 253899 43679 64200781
Oesophageal ulcer 85.86 10.58 114 254158 6096 64238364
Oedema mouth 85.78 10.58 79 254193 2794 64241666
Product use in unapproved indication 85.75 10.58 381 253891 176237 64068223
Ascites 85.71 10.58 71 254201 61930 64182530
Compression fracture 84.83 10.58 109 254163 5643 64238817
Hepatocellular injury 84.77 10.58 36 254236 45199 64199261
Lung neoplasm 84.51 10.58 114 254158 6191 64238269
Wrong technique in product usage process 84.28 10.58 79 254193 64895 64179565
Flushing 84.09 10.58 112 254160 78536 64165924
Type 2 diabetes mellitus 83.92 10.58 310 253962 33710 64210750
Seborrhoeic keratosis 83.09 10.58 67 254205 1973 64242487
Intentional self-injury 82.63 10.58 9 254263 29035 64215425
Hospitalisation 82.57 10.58 105 254167 75102 64169358
Aggression 81.64 10.58 40 254232 46192 64198268
Somnolence 81.40 10.58 470 253802 203175 64041285
Dehydration 81.02 10.58 511 253761 216252 64028208
Sinus disorder 81.01 10.58 195 254077 16713 64227747
Sciatica 80.77 10.58 218 254054 20046 64224414
Anaphylactic reaction 80.56 10.58 91 254181 68573 64175887
Infection 79.83 10.58 1095 253177 183785 64060675
Cardiac failure 79.46 10.58 262 254010 132111 64112349
Neoplasm progression 79.36 10.58 31 254241 40933 64203527
Jaw cyst 79.36 10.58 27 254245 109 64244351
Varicose vein 79.28 10.58 85 254187 3622 64240838
Tenosynovitis stenosans 79.04 10.58 64 254208 1896 64242564
Carotid bruit 78.84 10.58 43 254229 640 64243820
Bone marrow failure 78.07 10.58 46 254226 47906 64196554
Eustachian tube dysfunction 77.93 10.58 33 254239 268 64244192
Gastritis 77.90 10.58 354 253918 42264 64202196
Cardiac murmur 77.87 10.58 153 254119 11410 64233050
Rectocele 77.69 10.58 40 254232 526 64243934
Limb asymmetry 77.49 10.58 40 254232 529 64243931
Trismus 77.24 10.58 96 254176 4805 64239655
Oroantral fistula 75.84 10.58 35 254237 356 64244104
Lower respiratory tract infection 75.46 10.58 634 253638 93980 64150480
Headache 74.78 10.58 1556 252716 527911 63716549
Stomatitis 74.35 10.58 709 253563 108896 64135564
Tooth infection 73.87 10.58 172 254100 14429 64230031
Bone sequestrum 73.70 10.58 50 254222 1122 64243338
Tremor 73.62 10.58 317 253955 147913 64096547
Pulmonary oedema 72.54 10.58 124 254148 78550 64165910
Spinal disorder 72.03 10.58 126 254146 8596 64235864
Tooth deposit 71.80 10.58 29 254243 206 64244254
Sjogren's syndrome 71.70 10.58 41 254231 672 64243788
Cytomegalovirus infection 70.67 10.58 29 254243 37170 64207290
Feeling abnormal 70.54 10.58 279 253993 133323 64111137
Red blood cell sedimentation rate 70.50 10.58 80 254192 3634 64240826
Gingival pain 70.38 10.58 105 254167 6262 64238198
Fibromyalgia 70.00 10.58 303 253969 35428 64209032
Product use issue 69.37 10.58 908 253364 150807 64093653
Spinal stenosis 69.27 10.58 163 254109 13768 64230692
Fracture 69.05 10.58 196 254076 18559 64225901
Decreased appetite 68.65 10.58 743 253529 280546 63963914
Bone fragmentation 68.49 10.58 38 254234 586 64243874
Thoracic vertebral fracture 68.28 10.58 87 254185 4466 64239994
Renal cyst 67.94 10.58 152 254120 12418 64232042
Renal impairment 67.50 10.58 288 253984 134729 64109731
Dental plaque 66.97 10.58 21 254251 61 64244399
Mastication disorder 66.38 10.58 63 254209 2316 64242144
Acute sinusitis 66.29 10.58 82 254190 4084 64240376
Abortion spontaneous 66.20 10.58 10 254262 25133 64219327
Rash maculo-papular 66.06 10.58 53 254219 46973 64197487
Lumbar vertebral fracture 65.55 10.58 94 254178 5408 64239052
Neurotoxicity 65.44 10.58 14 254258 27390 64217070
Bruxism 65.32 10.58 76 254196 3548 64240912
Sequestrectomy 65.08 10.58 41 254231 808 64243652
Tenosynovitis 64.98 10.58 144 254128 11689 64232771
Ankle fracture 64.50 10.58 164 254108 14546 64229914
Depression 64.45 10.58 1048 253224 182243 64062217
Diabetic ketoacidosis 64.03 10.58 19 254253 29826 64214634
Unevaluable event 63.60 10.58 63 254209 50426 64194034
Blood glucose increased 63.16 10.58 188 254084 97885 64146575
Purulence 62.60 10.58 56 254216 1906 64242554
Cholestasis 62.50 10.58 51 254221 44821 64199639
Anaphylactic shock 62.06 10.58 21 254251 30307 64214153
Accidental exposure to product 61.88 10.58 14 254258 26350 64218110
Malaise 61.78 10.58 1145 253127 395102 63849358
Transaminases increased 61.72 10.58 51 254221 44543 64199917
Internal fixation of fracture 61.52 10.58 28 254244 275 64244185
Polymyalgia rheumatica 61.48 10.58 71 254201 3288 64241172
Clostridium difficile infection 61.30 10.58 33 254239 36130 64208330
Drug ineffective for unapproved indication 61.24 10.58 23 254249 31110 64213350
Acetabulum fracture 60.75 10.58 33 254239 487 64243973
Bone metabolism disorder 60.72 10.58 31 254241 400 64244060
Premature delivery 60.71 10.58 3 254269 18586 64225874
Abdominal pain 60.48 10.58 867 253405 311508 63932952
Cardiogenic shock 60.45 10.58 26 254246 32401 64212059
Cytokine release syndrome 60.43 10.58 6 254266 20823 64223637
Drug ineffective 60.40 10.58 2704 251568 837543 63406917
Vertebral foraminal stenosis 60.12 10.58 42 254230 990 64243470
Peptic ulcer 60.08 10.58 89 254183 5274 64239186
Abnormal behaviour 59.50 10.58 29 254243 33593 64210867
Suicidal ideation 59.42 10.58 107 254165 66435 64178025
Joint injury 59.04 10.58 212 254060 22735 64221725
Mycotic allergy 59.03 10.58 41 254231 957 64243503
Joint dislocation 59.03 10.58 136 254136 11329 64233131
Thyroid neoplasm 58.73 10.58 62 254210 2595 64241865
Posterior reversible encephalopathy syndrome 58.45 10.58 10 254262 22936 64221524
Dermal sinus 58.27 10.58 15 254257 14 64244446
Kyphoscoliosis 57.50 10.58 25 254247 218 64244242
Poisoning 56.92 10.58 9 254263 21870 64222590
Oral pain 56.84 10.58 237 254035 27256 64217204
Postmenopause 56.65 10.58 14 254258 9 64244451
Bone formation decreased 56.26 10.58 18 254254 57 64244403
Hypoglycaemia 55.97 10.58 175 254097 89717 64154743
Toxic epidermal necrolysis 55.92 10.58 39 254233 37127 64207333
Restlessness 55.68 10.58 45 254227 39740 64204720
Blood bilirubin increased 55.58 10.58 88 254184 57465 64186995
Palmar-plantar erythrodysaesthesia syndrome 55.51 10.58 22 254250 28797 64215663
Injection site erythema 55.37 10.58 123 254149 70677 64173783
Hepatotoxicity 54.94 10.58 46 254226 39916 64204544
Myocardial infarction 54.93 10.58 405 253867 165416 64079044
Pleural effusion 54.43 10.58 285 253987 126274 64118186
Breast calcifications 54.41 10.58 36 254236 774 64243686
Back disorder 54.21 10.58 121 254151 9869 64234591
Aortic arteriosclerosis 54.12 10.58 102 254170 7374 64237086
Bladder disorder 53.80 10.58 104 254168 7663 64236797
Chronic sinusitis 53.40 10.58 92 254180 6200 64238260
Serotonin syndrome 53.05 10.58 46 254226 39236 64205224
Oral fibroma 52.95 10.58 14 254258 16 64244444
Iliotibial band syndrome 52.76 10.58 15 254257 27 64244433
Cognitive disorder 52.47 10.58 85 254187 55002 64189458
Patella fracture 52.26 10.58 46 254226 1532 64242928
Road traffic accident 52.23 10.58 250 254022 30495 64213965
Angioedema 52.04 10.58 103 254169 61718 64182742
Postmenopausal haemorrhage 51.92 10.58 44 254228 1391 64243069
Hair follicle tumour benign 51.92 10.58 28 254244 407 64244053
Status epilepticus 51.87 10.58 11 254261 21652 64222808
Osteogenesis imperfecta 51.71 10.58 22 254250 181 64244279
Scleritis 51.46 10.58 61 254211 2905 64241555
Shock 51.37 10.58 45 254227 38195 64206265
Skeletal injury 51.29 10.58 41 254231 1192 64243268
Rash erythematous 51.22 10.58 70 254202 48563 64195897
Epistaxis 51.11 10.58 206 254066 97925 64146535
Generalised tonic-clonic seizure 51.05 10.58 49 254223 39808 64204652
Barrett's oesophagus 50.98 10.58 34 254238 741 64243719
Anaemia of chronic disease 50.97 10.58 53 254219 2179 64242281
Oesophageal stenosis 50.89 10.58 69 254203 3765 64240695
Acute respiratory distress syndrome 50.89 10.58 47 254225 38888 64205572
Disturbance in attention 50.88 10.58 52 254220 41022 64203438
Treatment failure 50.43 10.58 692 253580 116124 64128336
Tongue disorder 50.21 10.58 132 254140 11948 64232512
Acquired oesophageal web 49.97 10.58 24 254248 269 64244191
Neuroleptic malignant syndrome 49.95 10.58 18 254254 24978 64219482
Drug eruption 49.69 10.58 277 253995 35859 64208601
Myelosuppression 49.64 10.58 16 254256 23814 64220646
Psoriasis 49.44 10.58 133 254139 71570 64172890
Enthesopathy 49.26 10.58 114 254158 9524 64234936
Hypervolaemia 49.12 10.58 47 254225 38238 64206222
Acute myocardial infarction 49.07 10.58 128 254144 69590 64174870
Disorientation 48.75 10.58 91 254181 55737 64188723
Tumour lysis syndrome 48.37 10.58 9 254263 19431 64225029
Osteonecrosis of external auditory canal 48.27 10.58 18 254254 100 64244360
Gingival abscess 48.12 10.58 32 254240 694 64243766
Red blood cell sedimentation rate increased 48.10 10.58 247 254025 30988 64213472
Neutropenic sepsis 47.81 10.58 16 254256 23256 64221204
Upper limb fracture 47.73 10.58 148 254124 14718 64229742
Inflammation 47.58 10.58 429 253843 64871 64179589
Plantar fasciitis 47.29 10.58 57 254215 2763 64241697
Pericardial effusion 47.16 10.58 51 254221 39203 64205257
Cervicobrachial syndrome 46.97 10.58 36 254236 983 64243477
Humerus fracture 46.78 10.58 99 254173 7786 64236674
Gingival swelling 46.74 10.58 67 254205 3853 64240607
Respiratory depression 46.65 10.58 17 254255 23426 64221034
Oestrogen deficiency 46.56 10.58 16 254256 67 64244393
Dermal cyst 46.47 10.58 49 254223 2048 64242412
Chronic obstructive pulmonary disease 46.40 10.58 456 253816 70592 64173868
Dystonia 46.37 10.58 9 254263 18856 64225604
Hypertension 46.29 10.58 1344 252928 257917 63986543
Musculoskeletal stiffness 46.13 10.58 712 253560 122494 64121966
Brain oedema 45.66 10.58 15 254257 22060 64222400
Steroid therapy 45.61 10.58 14 254258 37 64244423
Epilepsy 45.60 10.58 39 254233 33492 64210968
Skin discolouration 45.56 10.58 43 254229 35212 64209248
Pancreatitis 45.44 10.58 105 254167 59502 64184958
Uterine prolapse 45.22 10.58 31 254241 708 64243752
Urge incontinence 45.20 10.58 34 254238 902 64243558
Injection site swelling 45.11 10.58 58 254214 41295 64203165
Dysarthria 45.00 10.58 105 254167 59301 64185159
Pain in extremity 44.87 10.58 1536 252736 301549 63942911
COVID-19 pneumonia 44.77 10.58 6 254266 16498 64227962
Blood creatine phosphokinase increased 44.76 10.58 103 254169 58455 64186005
Synovial fluid analysis 44.64 10.58 42 254230 1527 64242933
Lumbosacral radiculopathy 44.52 10.58 25 254247 395 64244065
Accidental overdose 44.46 10.58 40 254232 33517 64210943
Intervertebral disc disorder 44.33 10.58 70 254202 4387 64240073
Breast mass 44.23 10.58 77 254195 5233 64239227
Respiratory distress 44.21 10.58 87 254185 52244 64192216
Iron deficiency anaemia 43.93 10.58 187 254085 21702 64222758
Feeling hot 43.92 10.58 70 254202 45593 64198867
Dupuytren's contracture 43.89 10.58 13 254259 29 64244431
Acute myeloid leukaemia 43.78 10.58 27 254245 27436 64217024
Withdrawal syndrome 43.53 10.58 19 254253 23473 64220987
Carotid artery disease 43.47 10.58 48 254224 2115 64242345
Fluid retention 43.06 10.58 108 254164 59498 64184962
Osteomalacia 43.00 10.58 39 254233 1352 64243108
Osteomyelitis acute 42.92 10.58 25 254247 425 64244035
Hyperbilirubinaemia 42.84 10.58 15 254257 21190 64223270
Melanocytic naevus 42.78 10.58 66 254206 4054 64240406
Open reduction of fracture 42.78 10.58 20 254252 210 64244250
Goitre 42.58 10.58 73 254199 4900 64239560
Unresponsive to stimuli 42.38 10.58 84 254188 50309 64194151
Hypoxia 42.24 10.58 191 254081 87958 64156502
Depressed mood 42.22 10.58 60 254212 40952 64203508
Comminuted fracture 42.19 10.58 28 254244 605 64243855
Ovarian disorder 42.16 10.58 25 254247 440 64244020
Groin pain 41.88 10.58 119 254153 11274 64233186
Colitis 41.85 10.58 107 254165 58567 64185893
Peripheral vascular disorder 41.73 10.58 90 254182 7171 64237289
Spinal meningeal cyst 41.73 10.58 12 254260 23 64244437
Pallor 41.68 10.58 55 254217 38726 64205734
Dyslipidaemia 41.53 10.58 104 254168 9138 64235322
Morton's neuralgia 40.91 10.58 13 254259 40 64244420
Osteopetrosis 40.86 10.58 9 254263 0 64244460
Bacteraemia 40.80 10.58 28 254244 26883 64217577
Malocclusion 40.55 10.58 16 254256 106 64244354
Mydriasis 40.52 10.58 6 254266 15306 64229154
Therapy cessation 40.39 10.58 41 254231 32448 64212012
Haemophagocytic lymphohistiocytosis 40.05 10.58 10 254262 17599 64226861
Dizziness 40.03 10.58 1342 252930 428821 63815639
Trigger finger 39.95 10.58 59 254213 3486 64240974
Pneumonitis 39.79 10.58 87 254185 50278 64194182
Irritability 39.60 10.58 52 254220 36694 64207766
Drug withdrawal syndrome 39.46 10.58 39 254233 31252 64213208
Haematotoxicity 39.35 10.58 3 254269 12893 64231567
Reversible airways obstruction 39.35 10.58 34 254238 1104 64243356
Actinic keratosis 39.30 10.58 72 254200 5093 64239367
Diverticulum intestinal 39.29 10.58 89 254183 7331 64237129
Psychotic disorder 39.29 10.58 47 254225 34531 64209929
Benign neoplasm of skin 39.27 10.58 15 254257 90 64244370
Hepatitis 39.19 10.58 75 254197 45507 64198953
Weight decreased 38.97 10.58 844 253428 284895 63959565
Blood pressure decreased 38.82 10.58 191 254081 86008 64158452
Multiple sclerosis relapse 38.68 10.58 64 254208 41071 64203389
Haemorrhage 38.58 10.58 171 254101 79180 64165280
Menopausal symptoms 38.57 10.58 39 254233 1551 64242909
Nocturia 38.51 10.58 114 254158 11051 64233409
Raynaud's phenomenon 38.51 10.58 32 254240 984 64243476
Hypothermia 38.50 10.58 15 254257 19841 64224619
Oesophageal disorder 38.32 10.58 47 254225 2320 64242140
Drug level increased 38.30 10.58 47 254225 34149 64210311
Dental alveolar anomaly 38.28 10.58 11 254261 21 64244439
Myoclonus 38.26 10.58 26 254246 25092 64219368
Dyskinesia 38.24 10.58 60 254212 39328 64205132
Aphasia 38.14 10.58 64 254208 40842 64203618
Bone fistula 37.96 10.58 14 254258 75 64244385
Eosinophilia 37.93 10.58 57 254215 38019 64206441
Emphysema 37.93 10.58 132 254140 13937 64230523
Oliguria 37.91 10.58 6 254266 14570 64229890
Device issue 37.90 10.58 21 254251 22627 64221833
Vaginal disorder 37.83 10.58 24 254248 479 64243981
Angiopathy 37.56 10.58 79 254193 6186 64238274
Skin laceration 37.54 10.58 193 254079 24224 64220236
Altered state of consciousness 37.51 10.58 57 254215 37845 64206615
Traumatic ulcer 37.50 10.58 12 254260 38 64244422
Cough 37.40 10.58 906 253366 301242 63943218
Increased tendency to bruise 37.32 10.58 100 254172 9155 64235305
Uterine leiomyoma 37.32 10.58 72 254200 5297 64239163
Illness 37.21 10.58 20 254252 21918 64222542
Dementia Alzheimer's type 37.09 10.58 31 254241 961 64243499
Thrombotic microangiopathy 36.85 10.58 10 254262 16645 64227815
Lymphocyte count decreased 36.73 10.58 65 254207 40634 64203826
Hypothyroidism 36.54 10.58 279 253993 40178 64204282
Agranulocytosis 36.40 10.58 59 254213 38170 64206290
Oxygen saturation decreased 36.33 10.58 260 254012 106916 64137544
Breast cyst 36.27 10.58 32 254240 1069 64243391
Atrophy 36.07 10.58 41 254231 1866 64242594
Body height decreased 36.06 10.58 87 254185 7467 64236993
Acute hepatic failure 35.96 10.58 30 254242 26082 64218378
Ventricular fibrillation 35.95 10.58 25 254247 23835 64220625
Product prescribing error 35.91 10.58 52 254220 35217 64209243
Therapy interrupted 35.88 10.58 17 254255 20019 64224441
Anuria 35.68 10.58 15 254257 18949 64225511
Pathogen resistance 35.39 10.58 4 254268 12539 64231921
Adenoidal disorder 35.30 10.58 15 254257 123 64244337
Cyst 35.21 10.58 116 254156 11911 64232549
Therapeutic product effect incomplete 35.09 10.58 251 254021 103231 64141229
Bone graft 35.07 10.58 25 254247 609 64243851
Tooth impacted 34.99 10.58 15 254257 126 64244334
Jaw fistula 34.83 10.58 14 254258 98 64244362
Peripheral swelling 34.81 10.58 1075 253197 208078 64036382
Red blood cell count decreased 34.69 10.58 88 254184 48298 64196162
Incorrect dose administered 34.59 10.58 123 254149 60642 64183818
Hypophosphatasia 34.58 10.58 11 254261 34 64244426
Hormone level abnormal 34.33 10.58 38 254234 1679 64242781
Bronchitis 34.27 10.58 611 253661 108132 64136328
Akathisia 34.23 10.58 3 254269 11507 64232953
Injection site reaction 34.13 10.58 84 254188 46580 64197880
Red blood cell sedimentation rate abnormal 33.87 10.58 11 254261 16295 64228165
Traumatic fracture 33.78 10.58 27 254245 785 64243675
Peripheral venous disease 33.54 10.58 76 254196 6262 64238198
Ventricular tachycardia 33.46 10.58 52 254220 34213 64210247
Hand fracture 33.44 10.58 65 254207 4809 64239651
Mental status changes 33.37 10.58 126 254146 61036 64183424
Drug tolerance 33.35 10.58 74 254198 6011 64238449
Intermittent claudication 33.23 10.58 50 254222 3004 64241456
Urticaria 33.19 10.58 396 253876 146921 64097539
Myocarditis 32.84 10.58 13 254259 17030 64227430
Facet joint syndrome 32.69 10.58 39 254233 1870 64242590
Gingival ulceration 32.69 10.58 27 254245 823 64243637
Bone formation increased 32.58 10.58 12 254260 64 64244396
Device dislocation 32.16 10.58 22 254250 21156 64223304
Plasma cell myeloma 32.11 10.58 85 254187 45990 64198470
Labelled drug-drug interaction medication error 32.08 10.58 24 254248 22038 64222422
Lethargy 32.03 10.58 162 254110 72432 64172028
Stevens-Johnson syndrome 31.55 10.58 54 254218 34195 64210265
Bronchitis chronic 31.43 10.58 56 254216 3876 64240584
Hyperthermia 31.41 10.58 11 254261 15539 64228921
Haemodialysis 31.34 10.58 14 254258 17063 64227397
X-ray of pelvis and hip abnormal 31.32 10.58 8 254264 7 64244453
Creatinine renal clearance decreased 31.27 10.58 9 254263 14412 64230048
Miosis 31.23 10.58 7 254265 13259 64231201
Trigeminal neuralgia 31.16 10.58 49 254223 3060 64241400
Vulvovaginal dryness 31.14 10.58 35 254237 1573 64242887
Poor dental condition 31.10 10.58 20 254252 409 64244051
Mammogram abnormal 30.97 10.58 20 254252 412 64244048
Renal tubular necrosis 30.95 10.58 25 254247 22085 64222375
Hypercalciuria 30.93 10.58 20 254252 413 64244047
Transplant rejection 30.80 10.58 15 254257 17386 64227074
Sialoadenitis 30.70 10.58 35 254237 1598 64242862
Arteriosclerosis coronary artery 30.65 10.58 132 254140 15397 64229063
Ear disorder 30.57 10.58 49 254223 3111 64241349
Immune reconstitution inflammatory syndrome 30.54 10.58 6 254266 12464 64231996
Maternal exposure timing unspecified 30.43 10.58 45 254227 2662 64241798
Hemiparesis 30.35 10.58 44 254228 29783 64214677
Product quality issue 30.28 10.58 44 254228 29755 64214705
Leukoplakia 30.23 10.58 12 254260 81 64244379
Carotid artery stenosis 30.22 10.58 84 254188 7857 64236603
Hallucination 30.12 10.58 166 254106 72622 64171838
Haematochezia 29.92 10.58 147 254125 66226 64178234
Chest discomfort 29.77 10.58 303 253969 115803 64128657
Nasal disorder 29.67 10.58 46 254226 2838 64241622
Enterocele 29.66 10.58 10 254262 39 64244421
Aplastic anaemia 29.61 10.58 9 254263 13911 64230549
Ear pain 29.60 10.58 185 254087 24951 64219509
Tooth resorption 29.53 10.58 9 254263 23 64244437
Purulent discharge 29.47 10.58 66 254206 5395 64239065
Haemoptysis 29.46 10.58 97 254175 48951 64195509
Renal injury 29.35 10.58 12 254260 15417 64229043
Dialysis 29.33 10.58 15 254257 16905 64227555
Vascular calcification 29.31 10.58 27 254245 955 64243505
Adjustment disorder with depressed mood 29.30 10.58 42 254230 2415 64242045
Hepatic encephalopathy 29.26 10.58 24 254248 21042 64223418
Tendon disorder 29.24 10.58 72 254200 6260 64238200
Phlebolith 29.22 10.58 11 254261 63 64244397
Gamma-glutamyltransferase increased 29.10 10.58 96 254176 48414 64196046
Chills 29.03 10.58 374 253898 136890 64107570
Injection site mass 28.92 10.58 16 254256 17254 64227206
Anxiety disorder 28.90 10.58 53 254219 3752 64240708
Extraskeletal ossification 28.80 10.58 11 254261 66 64244394
Onychomycosis 28.27 10.58 63 254209 5133 64239327
Dislocation of vertebra 28.26 10.58 47 254225 3077 64241383
Neuritis 28.09 10.58 29 254243 1182 64243278
Lenticular opacities 28.06 10.58 19 254253 425 64244035
Cerebral haemorrhage 28.03 10.58 105 254167 50985 64193475
Toxic skin eruption 28.01 10.58 21 254251 19263 64225197
Myofascial pain syndrome 27.98 10.58 35 254237 1763 64242697
End stage renal disease 27.96 10.58 4 254268 10471 64233989
Injection site bruising 27.78 10.58 64 254208 36309 64208151
Haematocrit decreased 27.66 10.58 116 254156 54539 64189921
Otitis externa 27.62 10.58 38 254234 2103 64242357
Asthma 27.55 10.58 528 253744 94697 64149763
Graft versus host disease 27.51 10.58 10 254262 13803 64230657
Musculoskeletal discomfort 27.39 10.58 132 254140 16145 64228315
Blood loss anaemia 27.35 10.58 118 254154 13774 64230686
Breast fibrosis 27.24 10.58 6 254266 0 64244460
Cardiac failure congestive 27.17 10.58 357 253915 130223 64114237
Pulmonary haemorrhage 26.95 10.58 9 254263 13100 64231360
Osteoma 26.92 10.58 9 254263 34 64244426
International normalised ratio increased 26.85 10.58 192 254080 78975 64165485
Skin exfoliation 26.80 10.58 89 254183 44796 64199664
Anxiety 26.75 10.58 1014 253258 201635 64042825
Mixed incontinence 26.72 10.58 9 254263 35 64244425
Ejection fraction decreased 26.68 10.58 45 254227 28662 64215798
Nightmare 26.66 10.58 26 254246 20967 64223493
Abdominal distension 26.51 10.58 246 254026 95748 64148712
Periarthritis 26.48 10.58 41 254231 2526 64241934
Oesophageal discomfort 26.33 10.58 15 254257 244 64244216
Extrapyramidal disorder 26.27 10.58 23 254249 19529 64224931
Fracture malunion 26.27 10.58 12 254260 119 64244341
Pancreatitis acute 26.26 10.58 84 254188 42771 64201689
Cervical polyp 26.18 10.58 12 254260 120 64244340
Inappropriate schedule of product administration 26.14 10.58 235 254037 92051 64152409
Shock haemorrhagic 26.09 10.58 17 254255 16774 64227686
Breast cancer in situ 26.08 10.58 24 254248 848 64243612
Essential hypertension 26.07 10.58 61 254211 5133 64239327
Neuropathy peripheral 26.05 10.58 317 253955 117208 64127252
Thalassaemia beta 26.03 10.58 7 254265 9 64244451
Acrochordon 25.96 10.58 24 254248 853 64243607
Electrocardiogram QRS complex prolonged 25.95 10.58 3 254269 9241 64235219
Hemiplegia 25.85 10.58 9 254263 12759 64231701
Klebsiella infection 25.81 10.58 10 254262 13271 64231189
Gallbladder disorder 25.75 10.58 134 254138 16896 64227564
Coma 25.75 10.58 221 254051 87394 64157066
Bone pain 25.74 10.58 294 253978 47278 64197182
Syncope 25.60 10.58 452 253820 157183 64087277
Vital capacity decreased 25.46 10.58 26 254246 1046 64243414
Muscle rigidity 25.42 10.58 19 254253 17454 64227006
Spondylolysis 25.29 10.58 11 254261 96 64244364
Glomerular filtration rate decreased 25.14 10.58 24 254248 19548 64224912
Torsade de pointes 25.10 10.58 19 254253 17344 64227116
Mood altered 25.07 10.58 16 254256 15963 64228497
Granuloma 25.03 10.58 70 254202 6571 64237889
Urinary tract discomfort 24.93 10.58 16 254256 326 64244134
Aspergillus infection 24.89 10.58 17 254255 16362 64228098
Drug-induced liver injury 24.81 10.58 100 254172 47543 64196917
Neutrophil count increased 24.77 10.58 38 254234 25136 64219324
Psychomotor hyperactivity 24.77 10.58 13 254259 14438 64230022
Limb injury 24.63 10.58 168 254104 23337 64221123
Blood glucose decreased 24.63 10.58 33 254239 23090 64221370
Otitis media 24.41 10.58 61 254211 5352 64239108
Neuroma 24.40 10.58 14 254258 231 64244229
Glucose tolerance impaired 24.37 10.58 68 254204 6375 64238085
Macular degeneration 24.35 10.58 63 254209 5647 64238813
Bone fissure 24.27 10.58 12 254260 144 64244316
Lacrimation increased 24.15 10.58 22 254250 18324 64226136
Mood swings 24.14 10.58 20 254252 17448 64227012
Multiple fractures 24.09 10.58 65 254207 5975 64238485
Tooth discolouration 24.01 10.58 24 254248 941 64243519
Benign bone neoplasm 23.97 10.58 8 254264 30 64244430
Hypertonic bladder 23.96 10.58 46 254226 3372 64241088
Ischaemic stroke 23.90 10.58 49 254223 28986 64215474
Pernicious anaemia 23.84 10.58 19 254253 550 64243910
Dry skin 23.82 10.58 112 254160 51049 64193411
Hyperammonaemia 23.77 10.58 5 254267 9899 64234561
Hypokalaemia 23.66 10.58 338 253934 121565 64122895
Mouth cyst 23.56 10.58 9 254263 54 64244406
Odontogenic cyst 23.52 10.58 7 254265 16 64244444
Laryngitis 23.51 10.58 96 254176 10935 64233525
Memory impairment 23.48 10.58 220 254052 85462 64158998
Blood urea increased 23.42 10.58 92 254180 44061 64200399
Upper-airway cough syndrome 23.40 10.58 82 254190 8688 64235772
Injection site pruritus 23.28 10.58 74 254198 37752 64206708
Face injury 23.27 10.58 43 254229 3062 64241398
Rectal polyp 23.26 10.58 27 254245 1257 64243203
Lipase increased 23.18 10.58 14 254258 14388 64230072
Metastases to central nervous system 23.13 10.58 13 254259 13899 64230561
Neoplasm skin 23.09 10.58 26 254246 1171 64243289
Chondromalacia 23.03 10.58 12 254260 162 64244298
Salivary gland mass 23.02 10.58 9 254263 58 64244402
Frequent bowel movements 22.87 10.58 23 254249 18282 64226178
Costochondritis 22.79 10.58 34 254238 2027 64242433
Hormone therapy 22.70 10.58 5 254267 0 64244460
Therapeutic response shortened 22.70 10.58 6 254266 10164 64234296
Laryngeal ulceration 22.69 10.58 11 254261 126 64244334
Abdominal pain upper 22.69 10.58 521 253751 174509 64069951
Vertigo positional 22.68 10.58 41 254231 2870 64241590
Palatal disorder 22.66 10.58 17 254255 449 64244011
Epicondylitis 22.60 10.58 32 254240 1819 64242641
Inappropriate antidiuretic hormone secretion 22.56 10.58 33 254239 22256 64222204
Alanine aminotransferase abnormal 22.51 10.58 69 254203 6819 64237641
Retinitis 22.50 10.58 34 254238 2051 64242409
Nodule 22.34 10.58 134 254138 17813 64226647
Cytopenia 22.28 10.58 17 254255 15454 64229006
Cardiac failure acute 22.23 10.58 19 254253 16325 64228135
Cataract nuclear 22.15 10.58 23 254249 944 64243516
Osteitis deformans 22.10 10.58 12 254260 177 64244283
Bradyphrenia 22.07 10.58 5 254267 9401 64235059
Foreign body 22.03 10.58 37 254235 2442 64242018
Animal scratch 21.64 10.58 23 254249 970 64243490
Thermohypoaesthesia 21.64 10.58 10 254262 102 64244358
Blood lactic acid increased 21.63 10.58 7 254265 10394 64234066
Pneumocystis jirovecii pneumonia 21.61 10.58 48 254224 27586 64216874
Urethral caruncle 21.59 10.58 9 254263 70 64244390
Menopause 21.56 10.58 30 254242 1678 64242782
Right ventricular failure 21.52 10.58 32 254240 21439 64223021
Peripheral sensory neuropathy 21.40 10.58 9 254263 11369 64233091
Lip neoplasm 21.39 10.58 6 254266 10 64244450
Second primary malignancy 21.29 10.58 11 254261 12326 64232134
Tardive dyskinesia 21.29 10.58 5 254267 9173 64235287
Musculoskeletal pain 21.26 10.58 444 253828 80850 64163610
Type V hyperlipidaemia 21.25 10.58 22 254250 900 64243560
Oesophageal ulcer haemorrhage 21.21 10.58 18 254254 570 64243890
Paranoia 21.06 10.58 20 254252 16332 64228128
Benign breast neoplasm 21.06 10.58 20 254252 736 64243724
Hyperkeratosis 20.97 10.58 66 254206 6615 64237845
Osteosclerosis 20.95 10.58 44 254228 3442 64241018
Liver function test increased 20.93 10.58 58 254214 30912 64213548
Hypernatraemia 20.84 10.58 11 254261 12178 64232282
Troponin increased 20.83 10.58 18 254254 15381 64229079
Sight disability 20.83 10.58 10 254262 112 64244348
Disseminated intravascular coagulation 20.82 10.58 62 254210 32286 64212174
Paraesthesia 20.81 10.58 389 253883 134133 64110327
Hepatic cytolysis 20.79 10.58 15 254257 14034 64230426
Major depression 20.78 10.58 73 254199 7743 64236717
Hyperparathyroidism 20.75 10.58 39 254233 2813 64241647
Conductive deafness 20.75 10.58 9 254263 78 64244382
Fibroadenoma of breast 20.73 10.58 13 254259 254 64244206
Fibroma 20.68 10.58 19 254253 670 64243790
Haematemesis 20.50 10.58 279 253993 46720 64197740
Kidney transplant rejection 20.50 10.58 6 254266 9505 64234955
Heavy menstrual bleeding 20.50 10.58 11 254261 12066 64232394
Full blood count decreased 20.44 10.58 36 254236 22546 64221914
Dental prosthesis user 20.43 10.58 7 254265 29 64244431
Seasonal allergy 20.39 10.58 96 254176 11630 64232830
Dental pulp disorder 20.38 10.58 6 254266 13 64244447
Deafness 20.31 10.58 133 254139 18226 64226234
Coccydynia 20.31 10.58 26 254246 1341 64243119
Proteinuria 20.20 10.58 50 254222 27673 64216787
Gastric ulcer 20.20 10.58 195 254077 30039 64214421
Neurosensory hypoacusis 20.19 10.58 12 254260 212 64244248
Dysgeusia 20.18 10.58 106 254166 46941 64197519
Pseudarthrosis 20.16 10.58 13 254259 267 64244193
Hypersomnia 20.14 10.58 29 254243 19688 64224772
Tachypnoea 20.09 10.58 47 254225 26524 64217936
Arteriosclerosis 20.05 10.58 119 254153 15758 64228702
Device occlusion 20.04 10.58 7 254265 9906 64234554
Atrial fibrillation 19.79 10.58 518 253754 170571 64073889
Substance abuse 19.78 10.58 6 254266 9286 64235174
Spondylitis 19.78 10.58 40 254232 3046 64241414
Red cell distribution width increased 19.76 10.58 12 254260 12297 64232163
Nasal polyps 19.74 10.58 44 254228 3585 64240875
No adverse event 19.67 10.58 53 254219 28508 64215952
Benign neoplasm 19.66 10.58 21 254251 891 64243569
White blood cell count increased 19.62 10.58 166 254106 65848 64178612
Burning sensation 19.61 10.58 115 254157 49549 64194911
Breath odour 19.58 10.58 27 254245 1497 64242963
Parathyroid disorder 19.49 10.58 15 254257 412 64244048
Haemodynamic instability 19.49 10.58 18 254254 14894 64229566
Progressive multifocal leukoencephalopathy 19.44 10.58 26 254246 18206 64226254
Hypophagia 19.43 10.58 85 254187 39502 64204958
Erosive oesophagitis 19.42 10.58 36 254236 2570 64241890
Cushingoid 19.35 10.58 70 254202 7533 64236927
Seronegative arthritis 19.33 10.58 37 254235 2706 64241754
Delirium 19.24 10.58 177 254095 69017 64175443
Arrhythmia 19.14 10.58 126 254146 52818 64191642
Thrombosis 19.09 10.58 182 254090 70460 64174000
Bladder prolapse 19.03 10.58 23 254249 1118 64243342
Cervical spinal stenosis 19.00 10.58 31 254241 1998 64242462
Live birth 18.95 10.58 91 254181 11113 64233347
Psoriatic arthropathy 18.91 10.58 257 254015 43024 64201436
Delusion 18.90 10.58 26 254246 17988 64226472
Haemolysis 18.82 10.58 10 254262 11029 64233431
Mental impairment 18.79 10.58 22 254250 16321 64228139
Blood lactate dehydrogenase increased 18.79 10.58 67 254205 33011 64211449
Amino acid level increased 18.77 10.58 17 254255 588 64243872
Hyperglycaemia 18.72 10.58 152 254120 60816 64183644
Leukoplakia oral 18.68 10.58 12 254260 245 64244215
Pruritus 18.65 10.58 1024 253248 311376 63933084
Orthostatic hypotension 18.57 10.58 108 254164 46630 64197830
Acute pulmonary oedema 18.54 10.58 14 254258 12795 64231665
Periostitis 18.48 10.58 16 254256 521 64243939
Influenza like illness 18.41 10.58 155 254117 61547 64182913
Gastrooesophageal cancer 18.35 10.58 5 254267 7 64244453
Infusion site pain 18.35 10.58 9 254263 10388 64234072
Anger 18.31 10.58 21 254251 15720 64228740
Bone atrophy 18.30 10.58 6 254266 21 64244439
Hyperparathyroidism primary 18.27 10.58 14 254258 382 64244078
Embolism 18.19 10.58 13 254259 12222 64232238
Fear of injection 18.19 10.58 58 254214 5854 64238606
Rash 18.17 10.58 2069 252203 456480 63787980
Uterine cervix atrophy 18.16 10.58 4 254268 0 64244460
Traumatic occlusion 18.16 10.58 4 254268 0 64244460
Metastases to lung 18.15 10.58 20 254252 15244 64229216
Vaginal dysplasia 18.08 10.58 6 254266 22 64244438
Antinuclear antibody positive 18.04 10.58 60 254212 6190 64238270
Knee deformity 17.99 10.58 20 254252 888 64243572
Cerebral small vessel ischaemic disease 17.99 10.58 20 254252 888 64243572
Catatonia 17.98 10.58 4 254268 7616 64236844
Skin cancer 17.96 10.58 94 254178 11880 64232580
Hypomagnesaemia 17.89 10.58 81 254191 37295 64207165
Rash pruritic 17.88 10.58 322 253950 57082 64187378
Uterine polyp 17.86 10.58 24 254248 1298 64243162
Systemic inflammatory response syndrome 17.85 10.58 9 254263 10226 64234234
Rash macular 17.82 10.58 42 254230 23643 64220817
Enterococcal infection 17.81 10.58 17 254255 13849 64230611
Blood pressure increased 17.77 10.58 531 253741 172021 64072439
Suspected suicide 17.69 10.58 6 254266 8648 64235812
Presbyopia 17.66 10.58 16 254256 554 64243906
Mania 17.60 10.58 23 254249 16263 64228197
Osteodystrophy 17.59 10.58 5 254267 9 64244451
Tympanosclerosis 17.59 10.58 5 254267 9 64244451
Hypertensive crisis 17.52 10.58 28 254244 18220 64226240
Tooth dislocation 17.49 10.58 6 254266 25 64244435
Acute respiratory failure 17.47 10.58 120 254152 49814 64194646
Acne 17.31 10.58 41 254231 23040 64221420
Radicular pain 17.31 10.58 13 254259 344 64244116
Atelectasis 17.31 10.58 174 254098 27092 64217368
Wound complication 17.29 10.58 44 254228 3904 64240556
Ventricular arrhythmia 17.28 10.58 4 254268 7411 64237049
BK virus infection 17.27 10.58 4 254268 7408 64237052
Post transplant lymphoproliferative disorder 17.24 10.58 8 254264 9536 64234924
Hallucination, auditory 17.22 10.58 25 254247 16914 64227546
Metatarsalgia 17.19 10.58 11 254261 223 64244237
Hyperaesthesia 17.17 10.58 9 254263 10005 64234455
Device malfunction 16.98 10.58 27 254245 17606 64226854
Transfusion 16.91 10.58 28 254244 17966 64226494
Tympanic membrane perforation 16.82 10.58 24 254248 1374 64243086
Post laminectomy syndrome 16.81 10.58 12 254260 293 64244167
Metastases to liver 16.81 10.58 44 254228 23897 64220563
Pulmonary arterial hypertension 16.78 10.58 48 254224 25319 64219141
Hypoaesthesia oral 16.75 10.58 90 254182 11490 64232970
Pneumonia fungal 16.73 10.58 7 254265 8870 64235590
Back pain 16.73 10.58 1173 253099 248998 63995462
Iodine allergy 16.71 10.58 15 254257 513 64243947
Respiratory acidosis 16.69 10.58 9 254263 9846 64234614
Haemorrhage intracranial 16.69 10.58 44 254228 23840 64220620
Blood 25-hydroxycholecalciferol decreased 16.67 10.58 10 254262 180 64244280
Lymphopenia 16.64 10.58 49 254223 25608 64218852
Petechiae 16.58 10.58 30 254242 18596 64225864
Muscle spasticity 16.56 10.58 25 254247 16644 64227816
Sinus polyp 16.53 10.58 14 254258 442 64244018
Device difficult to use 16.52 10.58 9 254263 9789 64234671
Bronchial secretion retention 16.49 10.58 33 254239 2494 64241966
Injection site urticaria 16.47 10.58 12 254260 11169 64233291
Wrong product administered 16.41 10.58 5 254267 7715 64236745
Loss of employment 16.34 10.58 28 254244 1879 64242581
Bone abscess 16.32 10.58 14 254258 450 64244010
Scapula fracture 16.29 10.58 16 254256 614 64243846
Vaginal prolapse 16.29 10.58 11 254261 245 64244215
Cerebral infarction 16.23 10.58 95 254177 40949 64203511
Multiple-drug resistance 16.20 10.58 3 254269 6499 64237961
Oral discharge 16.13 10.58 11 254261 249 64244211
Impaired quality of life 16.09 10.58 3 254269 6468 64237992
Blood creatinine decreased 16.04 10.58 4 254268 7046 64237414
Tongue geographic 16.01 10.58 7 254265 62 64244398
Hepatic function abnormal 16.00 10.58 169 254103 64144 64180316
Oesophageal carcinoma 15.95 10.58 48 254224 4695 64239765
Disease recurrence 15.86 10.58 67 254205 31443 64213017
Bursa disorder 15.83 10.58 10 254262 198 64244262
Grief reaction 15.83 10.58 11 254261 257 64244203
Nephropathy toxic 15.78 10.58 28 254244 17486 64226974
Condition aggravated 15.76 10.58 1259 253013 371167 63873293
Nerve degeneration 15.72 10.58 11 254261 260 64244200
Respiratory disorder 15.69 10.58 81 254191 36030 64208430
Generalised oedema 15.67 10.58 37 254235 20816 64223644
Mandibular mass 15.66 10.58 10 254262 202 64244258
Avulsion fracture 15.65 10.58 11 254261 262 64244198
Impaired fasting glucose 15.64 10.58 12 254260 328 64244132
Clavicle fracture 15.61 10.58 41 254231 3708 64240752
Injection site warmth 15.61 10.58 18 254254 13444 64231016
Joint range of motion decreased 15.61 10.58 130 254142 19213 64225247
Acute coronary syndrome 15.55 10.58 33 254239 19277 64225183
Photosensitivity reaction 15.53 10.58 30 254242 18143 64226317
Breast neoplasm 15.51 10.58 18 254254 838 64243622
Cytomegalovirus viraemia 15.46 10.58 12 254260 10816 64233644
SARS-CoV-2 test positive 15.45 10.58 3 254269 6283 64238177
Taste disorder 15.42 10.58 9 254263 9424 64235036
Staphylococcal bacteraemia 15.40 10.58 11 254261 10344 64234116
Skin plaque 15.38 10.58 8 254264 8932 64235528
Left ventricular dysfunction 15.37 10.58 27 254245 16927 64227533
Peritonitis 15.37 10.58 49 254223 24974 64219486
Lip neoplasm malignant stage unspecified 15.36 10.58 5 254267 17 64244443
Ilium fracture 15.32 10.58 10 254262 210 64244250
Hepatocellular carcinoma 15.25 10.58 7 254265 8396 64236064
Product storage error 15.24 10.58 18 254254 13300 64231160
Cerebrovascular disorder 15.21 10.58 39 254233 3476 64240984
Hepatomegaly 15.20 10.58 27 254245 16855 64227605
Oesophageal injury 15.18 10.58 7 254265 71 64244389
Toxic encephalopathy 15.16 10.58 10 254262 9805 64234655
Incision site cellulitis 15.16 10.58 8 254264 111 64244349
Electrolyte imbalance 15.11 10.58 50 254222 25193 64219267
Soft tissue inflammation 15.07 10.58 10 254262 216 64244244
Circulatory collapse 15.03 10.58 75 254197 33657 64210803
Parathyroid tumour benign 15.03 10.58 16 254256 676 64243784
Breast necrosis 15.02 10.58 7 254265 73 64244387
Erythema 15.00 10.58 594 253678 186476 64057984
Meniere's disease 15.00 10.58 9 254263 162 64244298
Lacunar infarction 15.00 10.58 52 254220 5480 64238980
Constipation 14.95 10.58 745 253527 228592 64015868
Restrictive pulmonary disease 14.94 10.58 29 254243 2143 64242317
Cellulitis 14.93 10.58 479 253793 93178 64151282
Vascular headache 14.93 10.58 6 254266 42 64244418
Drug dependence 14.88 10.58 74 254198 33238 64211222
Pharyngeal oedema 14.75 10.58 24 254248 15507 64228953
Clonus 14.69 10.58 3 254269 6064 64238396
Lipoma 14.69 10.58 32 254240 2567 64241893
Hypertransaminasaemia 14.67 10.58 5 254267 7186 64237274
Vision blurred 14.64 10.58 259 254013 90057 64154403
Labile hypertension 14.63 10.58 14 254258 520 64243940
Fallopian tube disorder 14.56 10.58 10 254262 229 64244231
Fibrous dysplasia of bone 14.52 10.58 4 254268 6 64244454
Labyrinthitis 14.49 10.58 32 254240 2591 64241869
Throat tightness 14.47 10.58 45 254227 23115 64221345
Actinic elastosis 14.46 10.58 6 254266 46 64244414
Rhinitis 14.45 10.58 82 254190 10683 64233777
Pyogenic granuloma 14.44 10.58 13 254259 446 64244014
Tongue ulceration 14.44 10.58 39 254233 3587 64240873
Persistent depressive disorder 14.44 10.58 19 254253 1007 64243453
Renal tubular disorder 14.42 10.58 3 254269 5984 64238476
Heart rate decreased 14.40 10.58 143 254129 54924 64189536
Hospice care 14.39 10.58 6 254266 7619 64236841
Poliomyelitis 14.35 10.58 6 254266 47 64244413
Amenorrhoea 14.33 10.58 4 254268 6535 64237925
Immunodeficiency 14.33 10.58 26 254246 16098 64228362
Cerebrovascular accident 14.26 10.58 423 253849 137160 64107300
Intestinal perforation 14.23 10.58 24 254248 15289 64229171
Mastoid disorder 14.18 10.58 5 254267 23 64244437
Apathy 14.16 10.58 14 254258 11218 64233242
Staphylococcal sepsis 14.16 10.58 18 254254 12881 64231579
Haemolytic anaemia 14.16 10.58 26 254246 16027 64228433
Osteorrhagia 14.14 10.58 4 254268 7 64244453
Aplasia pure red cell 14.10 10.58 5 254267 7009 64237451
Crying 14.05 10.58 37 254235 20053 64224407
Blood pressure abnormal 14.00 10.58 22 254250 14413 64230047
Dermatitis acneiform 13.88 10.58 8 254264 8435 64236025
Therapeutic response decreased 13.87 10.58 135 254137 52053 64192407
Cystitis haemorrhagic 13.87 10.58 7 254265 7949 64236511
Weight bearing difficulty 13.85 10.58 32 254240 2671 64241789
Abortion induced 13.83 10.58 4 254268 6384 64238076
Hypocalcaemia 13.80 10.58 102 254170 41651 64202809
Giant cell arteritis 13.76 10.58 29 254243 2274 64242186
Nasopharyngitis 13.74 10.58 923 253349 195150 64049310
Oesophagitis chemical 13.73 10.58 6 254266 53 64244407
Ataxia 13.73 10.58 43 254229 22041 64222419
Therapeutic response unexpected 13.73 10.58 29 254243 16972 64227488
Carcinoid tumour pulmonary 13.70 10.58 11 254261 322 64244138
Myelodysplastic syndrome 13.66 10.58 59 254213 27520 64216940
Walking aid user 13.66 10.58 55 254217 6226 64238234
Post procedural constipation 13.64 10.58 6 254266 54 64244406
Osteoporotic fracture 13.63 10.58 38 254234 3560 64240900
Deafness traumatic 13.62 10.58 3 254269 0 64244460
Vulva cyst 13.62 10.58 3 254269 0 64244460
Erythroplasia 13.62 10.58 3 254269 0 64244460
Lipoma of breast 13.62 10.58 3 254269 0 64244460
Vaginal stricture 13.62 10.58 3 254269 0 64244460
External fixation of fracture 13.62 10.58 3 254269 0 64244460
Intestinal mucosal tear 13.62 10.58 3 254269 0 64244460
Bartholin's cyst 13.62 10.58 3 254269 0 64244460
Resorption bone decreased 13.62 10.58 3 254269 0 64244460
Nervous system disorder 13.61 10.58 46 254226 23032 64221428
Hypoalbuminaemia 13.57 10.58 31 254241 17643 64226817
Staphylococcal infection 13.51 10.58 131 254141 50547 64193913
Cutis laxa 13.48 10.58 8 254264 141 64244319
Vitreous detachment 13.43 10.58 26 254246 1918 64242542
Dyspnoea exertional 13.41 10.58 207 254065 73523 64170937
Parophthalmia 13.41 10.58 11 254261 332 64244128
Ileus 13.39 10.58 46 254226 22920 64221540
Sleep apnoea syndrome 13.38 10.58 178 254094 29654 64214806
Oesophagitis haemorrhagic 13.34 10.58 14 254258 582 64243878
Intraocular lens implant 13.30 10.58 11 254261 336 64244124
Hypersensitivity vasculitis 13.29 10.58 5 254267 6756 64237704
Glaucoma 13.26 10.58 110 254162 16238 64228222
Musculoskeletal disorder 13.22 10.58 118 254154 17788 64226672
Oesophageal irritation 13.21 10.58 7 254265 98 64244362
Anhedonia 13.19 10.58 21 254251 13685 64230775
Pulmonary congestion 13.15 10.58 49 254223 23831 64220629
Eustachian tube disorder 13.09 10.58 6 254266 60 64244400
Brain injury 13.06 10.58 12 254260 9953 64234507
Calcinosis 13.02 10.58 26 254246 1962 64242498
Nystagmus 13.01 10.58 10 254262 9058 64235402
Bone callus excessive 12.95 10.58 5 254267 31 64244429
Pharyngeal swelling 12.95 10.58 3 254269 5556 64238904
Peritonitis bacterial 12.94 10.58 10 254262 9033 64235427
Influenza B virus test positive 12.92 10.58 11 254261 350 64244110
Paralysis 12.92 10.58 16 254256 11579 64232881
Deep vein thrombosis postoperative 12.91 10.58 21 254251 1350 64243110
Emotional distress 12.91 10.58 86 254186 35952 64208508
Polyneuropathy 12.90 10.58 38 254234 19856 64224604
Peripheral coldness 12.90 10.58 21 254251 13563 64230897
Face oedema 12.87 10.58 52 254220 24709 64219751
Hepatosplenic T-cell lymphoma 12.79 10.58 16 254256 806 64243654
Anti-cyclic citrullinated peptide antibody 12.78 10.58 21 254251 1361 64243099
Hyponatraemia 12.78 10.58 467 253805 147872 64096588
Cardiomyopathy 12.71 10.58 54 254218 25302 64219158
Heparin-induced thrombocytopenia 12.62 10.58 9 254263 8470 64235990
Hepatic necrosis 12.60 10.58 9 254263 8464 64235996
Prothrombin time prolonged 12.59 10.58 27 254245 15714 64228746
Sudden death 12.59 10.58 39 254233 20057 64224403
Coagulopathy 12.55 10.58 74 254198 31846 64212614
Product dispensing error 12.55 10.58 16 254256 11434 64233026
Rheumatoid arthritis 12.53 10.58 779 253493 163515 64080945
Muscle twitching 12.53 10.58 36 254236 18962 64225498
Animal bite 12.51 10.58 27 254245 2152 64242308
Expired product administered 12.50 10.58 4 254268 5983 64238477
Head discomfort 12.49 10.58 17 254255 11817 64232643
Hepatitis C 12.48 10.58 15 254257 11000 64233460
Skin burning sensation 12.44 10.58 14 254258 10569 64233891
Blood albumin decreased 12.43 10.58 42 254230 21031 64223429
Hepatitis acute 12.43 10.58 21 254251 13368 64231092
Numb chin syndrome 12.42 10.58 4 254268 13 64244447
Tunnel vision 12.40 10.58 18 254254 1047 64243413
Cubital tunnel syndrome 12.39 10.58 10 254262 295 64244165
Leukoencephalopathy 12.34 10.58 6 254266 6961 64237499
Mouth ulceration 12.32 10.58 188 254084 32256 64212204
Ureterolithiasis 12.32 10.58 34 254238 3167 64241293
Gastric ulcer haemorrhage 12.26 10.58 64 254208 8079 64236381
Eyelid disorder 12.24 10.58 21 254251 1410 64243050
Restless legs syndrome 12.23 10.58 112 254160 17004 64227456
Dysplastic naevus syndrome 12.20 10.58 4 254268 14 64244446
Gastric disorder 12.20 10.58 172 254100 29025 64215435
Gastrointestinal tract adenoma 12.14 10.58 12 254260 464 64243996
Drug level below therapeutic 12.14 10.58 7 254265 7377 64237083
Tooth erosion 12.06 10.58 11 254261 384 64244076
Activated partial thromboplastin time prolonged 12.03 10.58 20 254252 12811 64231649
Ketoacidosis 12.02 10.58 6 254266 6857 64237603
Jaw clicking 11.99 10.58 4 254268 15 64244445
Pelvic floor muscle weakness 11.99 10.58 4 254268 15 64244445
Drug abuser 11.92 10.58 4 254268 5804 64238656
Rosacea 11.92 10.58 35 254237 3378 64241082
Dystrophic calcification 11.91 10.58 7 254265 121 64244339
Partial seizures 11.90 10.58 7 254265 7300 64237160
Coma scale abnormal 11.90 10.58 8 254264 7766 64236694
Abdominal hernia 11.88 10.58 45 254227 4950 64239510
Otitis media acute 11.88 10.58 18 254254 1088 64243372
Hypereosinophilic syndrome 11.87 10.58 12 254260 477 64243983
Atrial flutter 11.87 10.58 38 254234 19342 64225118
Facial pain 11.85 10.58 62 254210 7833 64236627
Abdominal abscess 11.84 10.58 5 254267 6299 64238161
Dermatitis exfoliative 11.83 10.58 14 254258 10338 64234122
Erythema marginatum 11.79 10.58 4 254268 16 64244444
Callus formation delayed 11.79 10.58 4 254268 16 64244444
Intestinal ischaemia 11.78 10.58 17 254255 11532 64232928
Parkinson's disease 11.78 10.58 22 254250 1579 64242881
Blood parathyroid hormone increased 11.78 10.58 33 254239 3101 64241359
Crepitations 11.78 10.58 62 254210 7853 64236607
Blepharitis 11.74 10.58 29 254243 2526 64241934
Cold sweat 11.74 10.58 30 254242 16425 64228035
Cardiac failure chronic 11.71 10.58 11 254261 9030 64235430
Skin haemorrhage 11.65 10.58 10 254262 8575 64235885
Eye pruritus 11.62 10.58 20 254252 12639 64231821
Hypovolaemic shock 11.61 10.58 14 254258 10252 64234208
Bradypnoea 11.60 10.58 3 254269 5156 64239304
Polyuria 11.58 10.58 20 254252 12623 64231837
Affect lability 11.57 10.58 11 254261 8979 64235481
Breast hyperplasia 11.57 10.58 7 254265 128 64244332
Urinary tract disorder 11.57 10.58 33 254239 3133 64241327
Enchondromatosis 11.56 10.58 5 254267 43 64244417
Conjunctivitis 11.56 10.58 127 254145 20227 64224233
Macrognathia 11.55 10.58 3 254269 3 64244457
Osteoarthropathy 11.55 10.58 3 254269 3 64244457
Reaction to food additive 11.55 10.58 3 254269 3 64244457
Central nervous system lesion 11.55 10.58 18 254254 11831 64232629
Transplant dysfunction 11.55 10.58 6 254266 6702 64237758
Coronary arterial stent insertion 11.54 10.58 4 254268 5688 64238772
Debridement 11.54 10.58 22 254250 1604 64242856
Gingivitis ulcerative 11.49 10.58 9 254263 254 64244206
Oesophagitis ulcerative 11.48 10.58 16 254256 896 64243564
Cervical dysplasia 11.47 10.58 24 254248 1872 64242588
Jaundice 11.46 10.58 129 254143 48383 64196077
Hypoxic-ischaemic encephalopathy 11.44 10.58 7 254265 7145 64237315
Post-traumatic neck syndrome 11.42 10.58 24 254248 1878 64242582
Dental cyst 11.41 10.58 4 254268 18 64244442
Nasal congestion 11.36 10.58 166 254106 59492 64184968
Diabetic neuropathy 11.35 10.58 48 254224 5553 64238907
Bladder pain 11.31 10.58 23 254249 1758 64242702
Mitral valve incompetence 11.30 10.58 152 254120 25386 64219074
Normal newborn 11.30 10.58 4 254268 5613 64238847
Lip and/or oral cavity cancer 11.26 10.58 12 254260 508 64243952
Rheumatoid lung 11.25 10.58 28 254244 2451 64242009
Epstein-Barr virus infection 11.22 10.58 20 254252 12468 64231992
Parkinsonism 11.21 10.58 25 254247 14348 64230112
Euphoric mood 11.19 10.58 6 254266 6585 64237875
Stomatitis necrotising 11.18 10.58 8 254264 196 64244264
Chondrocalcinosis pyrophosphate 11.18 10.58 22 254250 1642 64242818
Intervertebral disc displacement 11.18 10.58 11 254261 423 64244037
Petit mal epilepsy 11.17 10.58 3 254269 5029 64239431
Poor personal hygiene 11.16 10.58 12 254260 513 64243947
Allergy to arthropod sting 11.15 10.58 7 254265 137 64244323
Stress cardiomyopathy 11.15 10.58 12 254260 9245 64235215
Complication of device insertion 11.10 10.58 3 254269 5009 64239451
Oropharyngeal pain 11.10 10.58 266 254006 88601 64155859
Uterine stenosis 11.09 10.58 3 254269 4 64244456
Pleuritic pain 11.09 10.58 62 254210 8034 64236426
Congenital bowing of long bones 11.07 10.58 4 254268 20 64244440
Salivary gland adenoma 11.07 10.58 4 254268 20 64244440
Abscess neck 11.05 10.58 17 254255 1042 64243418
Haemangioma of liver 11.03 10.58 17 254255 1043 64243417
Osteolysis 11.01 10.58 30 254242 2773 64241687
Corneal abrasion 11.01 10.58 16 254256 932 64243528
Uterovaginal prolapse 11.00 10.58 5 254267 49 64244411
Genital haemorrhage 10.99 10.58 4 254268 5518 64238942
Stupor 10.99 10.58 5 254267 6030 64238430
Meralgia paraesthetica 10.96 10.58 9 254263 272 64244188
Ammonia increased 10.93 10.58 7 254265 6970 64237490
Complications of bone marrow transplant 10.92 10.58 13 254259 622 64243838
Pulseless electrical activity 10.91 10.58 21 254251 12718 64231742
Central nervous system mass 10.90 10.58 6 254266 91 64244369
Mixed liver injury 10.86 10.58 4 254268 5477 64238983
Ganglioneuroma 10.85 10.58 7 254265 144 64244316
Repetitive strain injury 10.85 10.58 7 254265 144 64244316
Bladder diverticulum 10.84 10.58 6 254266 92 64244368
Pulmonary granuloma 10.80 10.58 23 254249 1816 64242644
Gouty arthritis 10.79 10.58 19 254253 1303 64243157
Injury 10.73 10.58 293 253979 55699 64188761
Drug level decreased 10.72 10.58 18 254254 11485 64232975
Therapy change 10.72 10.58 6 254266 6428 64238032
Crohn's disease 10.69 10.58 24 254248 1965 64242495
Bone sarcoma 10.67 10.58 6 254266 95 64244365
Pelvic cyst 10.65 10.58 5 254267 53 64244407
Abdominal bruit 10.61 10.58 4 254268 23 64244437

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BA04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
FDA CS M0006519 Diphosphonates
FDA EPC N0000175579 Bisphosphonate
CHEBI has role CHEBI:50643 dimethylallyltranstransferase inhibitors
CHEBI has role CHEBI:50646 antiosteoporotic
MeSH PA D050071 Bone Density Conservation Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Postmenopausal osteoporosis indication 102447009
Hypogonadal Osteoporosis in Males indication
Prevention of Glucocorticoid-Induced Osteoporosis indication
Glucocorticoid Induced Osteoporosis indication
Complex regional pain syndrome off-label use 128200000 DOID:3223
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Esophagitis contraindication 16761005 DOID:11963
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Vitamin D deficiency contraindication 34713006
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Stricture of esophagus contraindication 63305008
Hypercalcemia contraindication 66931009 DOID:12678
Fracture of femur contraindication 71620000
Duodenitis contraindication 72007001 DOID:8643
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Aseptic necrosis of bone of jaw contraindication 441809006
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Esophageal Obstruction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.27 acidic
pKa2 5.34 acidic
pKa3 6.32 acidic
pKa4 10.39 acidic
pKa5 12.82 acidic
pKa6 10.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 7.35 CHEMBL CHEMBL
Protein farnesyltransferase subunit beta Enzyme IC50 7.30 WOMBAT-PK
Farnesyl pyrophosphate synthase Enzyme Ki 7.02 CHEMBL
Farnesyl pyrophosphate synthase Enzyme IC50 5.77 CHEMBL
Isopentenyl-diphosphate Delta-isomerase 1 Enzyme IC50 5.77 CHEMBL
Farnesyl pyrophosphate synthase Enzyme IC50 4.82 CHEMBL
Farnesyl pyrophosphate synthase, EC 2.5.1.1, EC 2.5.1.10 Unclassified Ki 7.04 CHEMBL

External reference:

IDSource
4020932 VUID
N0000148414 NUI
D00939 KEGG_DRUG
121268-17-5 SECONDARY_CAS_RN
203152 RXNORM
C0771311 UMLSCUI
CHEBI:2567 CHEBI
212 PDB_CHEM_ID
CHEMBL870 ChEMBL_ID
CHEMBL675 ChEMBL_ID
DB00630 DRUGBANK_ID
2088 PUBCHEM_CID
3141 IUPHAR_LIGAND_ID
6462 INN_ID
X1J18R4W8P UNII
131536 MMSL
4146 MMSL
d03849 MMSL
005056 NDDF
005057 NDDF
4020932 VANDF
D019386 MESH_DESCRIPTOR_UI
391729003 SNOMEDCT_US
391730008 SNOMEDCT_US
421552005 SNOMEDCT_US
96290008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FOSAMAX HUMAN PRESCRIPTION DRUG LABEL 1 0006-0031 TABLET 70 mg ORAL NDA 28 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0270 TABLET 70 mg ORAL NDA 27 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0710 TABLET 70 mg ORAL NDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-0282 SOLUTION 70 mg ORAL ANDA 28 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1676 TABLET 5 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1678 TABLET 10 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1679 TABLET 35 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1680 TABLET 40 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1681 TABLET 70 mg ORAL ANDA 29 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 0178-0101 TABLET, EFFERVESCENT 70 mg ORAL NDA 20 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-696 TABLET 35 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-697 TABLET 70 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-718 TABLET 35 mg ORAL ANDA 29 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-719 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-631 TABLET 10 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-632 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-633 TABLET 70 mg ORAL ANDA 27 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 17139-400 TABLET, EFFERVESCENT 70 mg ORAL NDA 21 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-901 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-902 TABLET 70 mg ORAL ANDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-554 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-820 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-993 TABLET 35 mg ORAL ANDA 29 sections
alendronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-1091 TABLET 35 mg ORAL ANDA 27 sections
alendronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-1095 TABLET 70 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-2322 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-2322 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-3126 TABLET 70 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3593 TABLET 35 mg ORAL ANDA 29 sections
ALENDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 50090-4076 TABLET 35 mg ORAL ANDA 24 sections