lercanidipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 4157 100427-26-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lercanidipine hydrochloride
  • lercanidipine
  • masnidipine
  • zanidip
  • lercanidipine HCl
  • Molecular weight: 611.74
  • Formula: C36H41N3O6
  • CLOGP: 8
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 1
  • TPSA: 111.01
  • ALOGS: -6.59
  • ROTB: 14

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 10 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 455.75 16.86 464 17847 262951 63207760
Hyponatraemia 376.42 16.86 288 18023 111612 63359099
General physical health deterioration 169.59 16.86 247 18064 201155 63269556
Hyperkalaemia 163.48 16.86 131 18180 54072 63416639
Lactic acidosis 133.82 16.86 101 18210 38186 63432525
Hypokalaemia 130.23 16.86 155 18156 103649 63367062
Fall 122.82 16.86 316 17995 392018 63078693
Pemphigoid 119.84 16.86 53 18258 7291 63463420
Hypotension 119.80 16.86 251 18060 272353 63198358
Hypertensive crisis 114.41 16.86 65 18246 15221 63455490
Cholestasis 99.20 16.86 76 18235 29358 63441353
Anaemia 96.51 16.86 241 18070 293189 63177522
Product prescribing error 95.51 16.86 71 18240 26218 63444493
Labelled drug-drug interaction medication error 79.38 16.86 49 18262 13350 63457361
Hepatocellular injury 77.90 16.86 64 18247 27317 63443394
Drug ineffective 75.54 16.86 116 18195 1044649 62426062
Eosinophilia 72.84 16.86 57 18254 22699 63448012
Pain 71.88 16.86 65 18246 740563 62730148
Cell death 70.52 16.86 27 18284 2574 63468137
Drug interaction 69.86 16.86 183 18128 228948 63241763
Labile hypertension 69.54 16.86 18 18293 468 63470243
Atrial fibrillation 69.03 16.86 122 18189 116514 63354197
Pallor 67.83 16.86 62 18249 30506 63440205
Anuria 67.08 16.86 43 18268 12508 63458203
Abdominal discomfort 65.16 16.86 8 18303 320877 63149834
Ischaemic stroke 64.11 16.86 48 18263 17909 63452802
Medication error 62.10 16.86 76 18235 52208 63418503
Sprue-like enteropathy 61.98 16.86 18 18293 725 63469986
Vasoplegia syndrome 58.42 16.86 21 18290 1678 63469033
Bradycardia 57.41 16.86 87 18224 73140 63397571
Infusion related reaction 55.44 16.86 4 18307 245517 63225194
Confusional state 52.88 16.86 169 18142 236211 63234500
Arthropathy 52.51 16.86 4 18307 234788 63235923
Rheumatoid arthritis 49.89 16.86 7 18304 253812 63216899
Alopecia 49.14 16.86 18 18293 337518 63133193
Tachycardia 48.51 16.86 106 18205 118050 63352661
Drug hypersensitivity 47.95 16.86 15 18296 310672 63160039
Toxic skin eruption 47.24 16.86 35 18276 12850 63457861
Sinusitis 45.14 16.86 6 18305 226647 63244064
Swelling 44.87 16.86 12 18299 275366 63195345
Therapeutic product effect decreased 44.03 16.86 3 18308 193184 63277527
Orthostatic hypotension 43.64 16.86 53 18258 36107 63434604
Treatment failure 42.83 16.86 4 18307 199039 63271672
Product dose omission issue 42.61 16.86 8 18303 234305 63236406
Creutzfeldt-Jakob disease 42.50 16.86 10 18301 173 63470538
Death 42.36 16.86 28 18283 374353 63096358
Sopor 41.62 16.86 41 18270 22123 63448588
Hyperlactacidaemia 41.51 16.86 19 18292 2830 63467881
Tongue oedema 41.19 16.86 22 18289 4564 63466147
Haematochezia 41.08 16.86 63 18248 53481 63417230
Electrocardiogram QT prolonged 38.76 16.86 65 18246 59465 63411246
Product monitoring error 38.70 16.86 21 18290 4495 63466216
Renin increased 36.78 16.86 9 18302 185 63470526
Therapeutic drug monitoring analysis not performed 36.53 16.86 14 18297 1338 63469373
Haematemesis 35.77 16.86 44 18267 30368 63440343
Renal artery stenosis 35.13 16.86 15 18296 1894 63468817
Peripheral ischaemia 34.50 16.86 20 18291 4858 63465853
Rhabdomyolysis 34.12 16.86 52 18259 43899 63426812
Cerebral haematoma 34.01 16.86 18 18293 3665 63467046
Joint swelling 33.80 16.86 27 18284 327639 63143072
Diabetic metabolic decompensation 33.34 16.86 14 18297 1696 63469015
Hallucination, visual 33.12 16.86 34 18277 19264 63451447
Nasopharyngitis 33.06 16.86 16 18295 254241 63216470
Epileptic encephalopathy 32.98 16.86 9 18302 288 63470423
Arthralgia 32.32 16.86 73 18238 569637 62901074
Poisoning deliberate 31.43 16.86 26 18285 11192 63459519
Immune-mediated pancreatitis 29.08 16.86 7 18304 134 63470577
Cardiac failure 28.95 16.86 73 18238 89069 63381642
Walking disability 28.89 16.86 12 18299 1415 63469296
Helplessness 28.20 16.86 8 18303 296 63470415
Syncope 28.10 16.86 86 18225 117299 63353412
Renal failure 27.99 16.86 86 18225 117566 63353145
Hallucination, gustatory 27.94 16.86 6 18305 67 63470644
Discomfort 27.80 16.86 7 18304 167367 63303344
Necrotising myositis 27.40 16.86 9 18302 548 63470163
Myopathy 27.39 16.86 24 18287 11167 63459544
Convulsive threshold lowered 27.04 16.86 8 18303 344 63470367
Spontaneous haematoma 26.85 16.86 10 18301 883 63469828
Mental status changes postoperative 26.65 16.86 7 18304 193 63470518
Oesophageal food impaction 26.08 16.86 7 18304 210 63470501
Hypersensitivity 25.60 16.86 28 18283 292657 63178054
Radiation fibrosis 25.50 16.86 5 18306 34 63470677
Pulmonary vein occlusion 25.43 16.86 6 18305 105 63470606
Drug intolerance 25.41 16.86 31 18280 308630 63162081
Disturbance in attention 25.26 16.86 42 18269 38147 63432564
Confusion postoperative 25.21 16.86 7 18304 239 63470472
Rash maculo-papular 25.12 16.86 38 18273 31858 63438853
Presyncope 24.63 16.86 35 18276 27750 63442961
Hepatic enzyme increased 24.42 16.86 14 18297 202314 63268397
Polyuria 24.35 16.86 20 18291 8522 63462189
Retroperitoneal fibrosis 23.64 16.86 7 18304 302 63470409
Acute pulmonary oedema 23.05 16.86 19 18292 8139 63462572
Contraindicated product prescribed 23.03 16.86 10 18301 1315 63469396
Therapeutic drug monitoring analysis incorrectly performed 22.90 16.86 7 18304 337 63470374
Arterial spasm 22.87 16.86 5 18306 61 63470650
Altered state of consciousness 22.69 16.86 32 18279 25198 63445513
Haematoma 22.63 16.86 38 18273 34782 63435929
Blood creatinine increased 22.57 16.86 66 18245 87778 63382933
Hypocalcaemia 22.49 16.86 36 18275 31677 63439034
Hyperglycaemic hyperosmolar nonketotic syndrome 22.35 16.86 9 18302 980 63469731
Lip oedema 22.35 16.86 14 18297 3910 63466801
Haemorrhagic thyroid cyst 22.17 16.86 4 18307 16 63470695
Rhonchi 22.13 16.86 12 18299 2564 63468147
Hypertension 22.10 16.86 147 18164 279156 63191555
Prothrombin time shortened 22.04 16.86 11 18300 1984 63468727
Polyneuropathy 22.01 16.86 24 18287 14565 63456146
Pseudophaeochromocytoma 21.79 16.86 5 18306 77 63470634
Oedema peripheral 21.68 16.86 110 18201 189401 63281310
Degenerative mitral valve disease 21.28 16.86 4 18307 21 63470690
Nocturia 21.02 16.86 18 18293 8123 63462588
Wrong product administered 20.99 16.86 16 18295 6125 63464586
Arthritis 20.96 16.86 4 18307 115917 63354794
White blood cell count decreased 20.93 16.86 7 18304 139097 63331614
Hypovolaemic shock 20.76 16.86 16 18295 6225 63464486
Intestinal villi atrophy 20.60 16.86 6 18305 244 63470467
Oesophageal achalasia 20.52 16.86 7 18304 479 63470232
Product use issue 20.52 16.86 20 18291 220500 63250211
Miosis 20.51 16.86 17 18294 7336 63463375
Adenocarcinoma metastatic 20.42 16.86 5 18306 103 63470608
Eastern Cooperative Oncology Group performance status worsened 20.29 16.86 9 18302 1245 63469466
Metabolic acidosis 20.28 16.86 42 18269 45027 63425684
Hallucination, olfactory 20.26 16.86 6 18305 259 63470452
Mobility decreased 20.25 16.86 5 18306 121154 63349557
Lichenoid keratosis 20.19 16.86 10 18301 1773 63468938
Suicide attempt 19.89 16.86 50 18261 60868 63409843
Shock haemorrhagic 19.88 16.86 19 18292 9876 63460835
Arrhythmia 18.90 16.86 37 18274 38103 63432608
Traumatic haematoma 18.84 16.86 9 18302 1476 63469235
Morbid thoughts 18.82 16.86 7 18304 616 63470095
Postural tremor 18.60 16.86 6 18305 345 63470366
Overdose 18.57 16.86 74 18237 115004 63355707
Dysaesthesia 18.31 16.86 13 18298 4465 63466246
Frontotemporal dementia 18.24 16.86 6 18305 367 63470344
Ultrasound liver abnormal 18.21 16.86 4 18307 50 63470661
Infection 17.83 16.86 24 18287 229149 63241562
Hyperparathyroidism primary 17.83 16.86 6 18305 394 63470317
Mixed liver injury 17.66 16.86 13 18298 4722 63465989
Lymphopenia 17.61 16.86 24 18287 18303 63452408
Obstructive pancreatitis 17.50 16.86 6 18305 417 63470294
Pharyngeal haematoma 17.47 16.86 4 18307 61 63470650
Dyspnoea 17.30 16.86 277 18034 661036 62809675
Helicobacter infection 17.21 16.86 3 18308 92782 63377929
Cerebral salt-wasting syndrome 17.18 16.86 4 18307 66 63470645
Injection site pain 17.11 16.86 8 18303 129792 63340919
Splenic haemorrhage 17.11 16.86 5 18306 206 63470505
Accelerated hypertension 17.02 16.86 6 18305 453 63470258
Lymphocele 16.98 16.86 7 18304 810 63469901
Claudication of jaw muscles 16.96 16.86 4 18307 70 63470641
Depression 16.95 16.86 19 18292 196473 63274238
Neutropenia 16.90 16.86 97 18214 174908 63295803

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 254.24 15.51 467 14868 304521 34637075
General physical health deterioration 106.77 15.51 197 15138 128072 34813524
Lactic acidosis 86.97 15.51 91 15244 34681 34906915
Hyperkalaemia 78.08 15.51 122 15213 69267 34872329
Pemphigoid 62.74 15.51 42 15293 8624 34932972
Death 62.60 15.51 50 15285 397999 34543597
Hepatic vein dilatation 60.01 15.51 15 15320 217 34941379
Syncope 59.72 15.51 127 15208 91324 34850272
Inappropriate antidiuretic hormone secretion 58.68 15.51 47 15288 12706 34928890
Liver palpable 56.38 15.51 15 15320 281 34941315
Drug ineffective 56.26 15.51 71 15264 456680 34484916
Bradycardia 54.23 15.51 109 15226 75309 34866287
Metabolic acidosis 53.61 15.51 80 15255 43600 34897996
Narrow anterior chamber angle 52.34 15.51 12 15323 117 34941479
Atrial enlargement 48.21 15.51 16 15319 656 34940940
Hyponatraemia 45.18 15.51 107 15228 82584 34859012
Haematochezia 43.11 15.51 75 15260 46459 34895137
Hypoglycaemia 42.93 15.51 82 15253 54558 34887038
Inferior vena cava dilatation 42.44 15.51 15 15320 745 34940851
Product dose omission issue 41.01 15.51 3 15332 119708 34821888
Ventricular enlargement 40.51 15.51 14 15321 650 34940946
Hypomagnesaemia 38.96 15.51 48 15287 21803 34919793
Transient aphasia 38.74 15.51 12 15323 393 34941203
Eosinophilia 38.01 15.51 52 15283 26170 34915426
Lens dislocation 37.95 15.51 9 15326 103 34941493
Hypertensive crisis 37.62 15.51 31 15304 8720 34932876
Product prescribing error 37.12 15.51 48 15287 22879 34918717
Hypokalaemia 36.99 15.51 80 15255 58134 34883462
Meningorrhagia 36.34 15.51 9 15326 125 34941471
Vascular purpura 36.18 15.51 17 15318 1761 34939835
Drug interaction 35.02 15.51 193 15142 225753 34715843
Rash maculo-papular 34.74 15.51 52 15283 28399 34913197
Pancreatitis acute 32.33 15.51 50 15285 28091 34913505
Retinal artery occlusion 32.24 15.51 16 15319 1869 34939727
Electrocardiogram abnormal 32.12 15.51 29 15306 9218 34932378
Supine hypertension 31.67 15.51 10 15325 349 34941247
Dyspnoea at rest 31.24 15.51 20 15315 3808 34937788
Haematoma 30.12 15.51 46 15289 25559 34916037
Torsade de pointes 29.87 15.51 25 15310 7184 34934412
Completed suicide 29.61 15.51 4 15331 98164 34843432
Electrocardiogram QT prolonged 29.18 15.51 59 15276 40893 34900703
Sprue-like enteropathy 28.17 15.51 10 15325 503 34941093
Oedema peripheral 27.73 15.51 115 15220 119697 34821899
Hypotension 27.08 15.51 178 15157 221471 34720125
Cholestasis 25.68 15.51 44 15291 26904 34914692
Mesenteric artery thrombosis 25.60 15.51 9 15326 440 34941156
Coronary artery stenosis 25.52 15.51 26 15309 9590 34932006
Abdominal compartment syndrome 25.39 15.51 11 15324 942 34940654
Wrong drug 24.52 15.51 6 15329 79 34941517
Hemiplegia 24.48 15.51 22 15313 6950 34934646
Duplicate therapy error 24.44 15.51 7 15328 174 34941422
Cardiac failure chronic 24.06 15.51 23 15312 7856 34933740
Melaena 24.05 15.51 50 15285 35330 34906266
Nephroangiosclerosis 23.88 15.51 7 15328 189 34941407
Coma 23.73 15.51 58 15277 45620 34895976
Renal artery arteriosclerosis 23.67 15.51 5 15330 32 34941564
Hepatocellular injury 23.49 15.51 38 15297 22173 34919423
Renal impairment 22.87 15.51 92 15243 94421 34847175
Implant site inflammation 22.83 15.51 6 15329 107 34941489
Pneumonia 22.27 15.51 83 15252 362544 34579052
Product monitoring error 21.99 15.51 17 15318 4364 34937232
Pain 21.91 15.51 35 15300 204640 34736956
Platelet count decreased 21.42 15.51 13 15322 119704 34821892
Renal artery restenosis 21.39 15.51 4 15331 12 34941584
Post thrombotic syndrome 21.39 15.51 6 15329 138 34941458
Laryngeal leukoplakia 21.26 15.51 5 15330 55 34941541
Cerebral haematoma 21.21 15.51 17 15318 4598 34936998
Vasoplegia syndrome 21.10 15.51 12 15323 1844 34939752
Cell death 20.95 15.51 13 15322 2344 34939252
Presyncope 20.69 15.51 33 15302 19026 34922570
Mesenteric vein thrombosis 20.04 15.51 9 15326 840 34940756
Renal failure 19.82 15.51 111 15224 130446 34811150
Renal cyst 19.57 15.51 22 15313 9071 34932525
Systemic infection 19.40 15.51 17 15318 5195 34936401
Bundle branch block right 19.36 15.51 20 15315 7496 34934100
Anti factor VIII antibody positive 19.30 15.51 5 15330 84 34941512
Respiratory alkalosis 19.30 15.51 11 15324 1698 34939898
Retinal vein occlusion 19.24 15.51 11 15324 1708 34939888
Ischaemic stroke 18.99 15.51 31 15304 18219 34923377
Disease progression 18.97 15.51 12 15323 108065 34833531
Schizophrenia 18.70 15.51 21 15314 8645 34932951
Interstitial lung disease 18.63 15.51 67 15268 65215 34876381
Constipation 18.14 15.51 20 15315 136962 34804634
Toxicity to various agents 18.11 15.51 38 15297 200324 34741272
Hyperlactacidaemia 18.03 15.51 13 15322 3003 34938593
Cardiac failure congestive 17.99 15.51 7 15328 83263 34858333
Cerebral haemorrhage 17.76 15.51 44 15291 34893 34906703
Autoimmune enteropathy 17.64 15.51 4 15331 37 34941559
Splenomegaly 17.55 15.51 27 15308 15090 34926506
Gallbladder enlargement 17.46 15.51 9 15326 1139 34940457
Electrolyte imbalance 17.10 15.51 26 15309 14386 34927210
Hypoglycaemic encephalopathy 17.07 15.51 6 15329 293 34941303
Traumatic haemothorax 17.01 15.51 6 15329 296 34941300
Hepatic cytolysis 16.99 15.51 26 15309 14470 34927126
Dizziness 16.94 15.51 158 15177 218363 34723233
Fall 16.90 15.51 149 15186 202736 34738860
Nasopharyngitis 16.64 15.51 5 15330 69963 34871633
Basal ganglia haematoma 16.62 15.51 4 15331 49 34941547
Agranulocytosis 16.58 15.51 34 15301 23787 34917809
Bradyphrenia 16.57 15.51 15 15320 4783 34936813
Livedo reticularis 16.52 15.51 11 15324 2238 34939358
Body mass index abnormal 16.31 15.51 5 15330 158 34941438
Vertigo 16.09 15.51 35 15300 25501 34916095
Cholangiocarcinoma 16.09 15.51 9 15326 1340 34940256
Drug abuse 16.06 15.51 12 15323 99084 34842512
Blood triglycerides increased 16.04 15.51 25 15310 14134 34927462
Glycosylated haemoglobin abnormal 15.77 15.51 5 15330 177 34941419
Bundle branch block left 15.56 15.51 16 15319 5963 34935633

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 633.97 13.88 909 31634 518495 79193350
Hyponatraemia 326.47 13.88 382 32161 177466 79534379
General physical health deterioration 265.19 13.88 433 32110 274805 79437040
Hyperkalaemia 213.47 13.88 248 32295 114150 79597695
Lactic acidosis 190.62 13.88 186 32357 70173 79641672
Pemphigoid 164.47 13.88 93 32450 15222 79696623
Hypokalaemia 125.59 13.88 217 32326 143823 79568022
Hypotension 118.03 13.88 421 32122 439896 79271949
Product prescribing error 114.88 13.88 115 32428 44698 79667147
Drug ineffective 113.07 13.88 167 32376 1080746 78631099
Hypertensive crisis 110.39 13.88 81 32462 20689 79691156
Fall 109.03 13.88 440 32103 487189 79224656
Cholestasis 107.34 13.88 119 32424 51990 79659855
Eosinophilia 99.39 13.88 107 32436 45238 79666607
Bradycardia 97.57 13.88 188 32355 135369 79576476
Pain 87.68 13.88 95 32448 703707 79008138
Hepatocellular injury 86.70 13.88 102 32441 47491 79664354
Anaemia 85.78 13.88 384 32159 444631 79267214
Syncope 84.75 13.88 210 32333 179239 79532606
Completed suicide 83.55 13.88 4 32539 245763 79466082
Cell death 83.45 13.88 40 32503 4659 79707186
Sprue-like enteropathy 83.22 13.88 28 32515 1290 79710555
Drug interaction 81.31 13.88 360 32183 414823 79297022
Death 80.39 13.88 68 32475 566446 79145399
Haematochezia 80.23 13.88 135 32408 87510 79624335
Vasoplegia syndrome 70.91 13.88 33 32510 3597 79708248
Ischaemic stroke 70.53 13.88 77 32466 33054 79678791
Metabolic acidosis 68.83 13.88 122 32421 82407 79629438
Product dose omission issue 68.02 13.88 10 32533 247527 79464318
Anuria 67.42 13.88 61 32482 20902 79690943
Inappropriate antidiuretic hormone secretion 66.46 13.88 67 32476 26246 79685599
Infusion related reaction 66.36 13.88 8 32535 230229 79481616
Electrocardiogram QT prolonged 64.57 13.88 125 32418 90261 79621584
Labelled drug-drug interaction medication error 63.68 13.88 67 32476 27583 79684262
Nasopharyngitis 61.71 13.88 14 32529 253867 79457978
Labile hypertension 61.18 13.88 18 32525 531 79711314
Pallor 61.01 13.88 88 32455 49974 79661871
Hepatic vein dilatation 60.08 13.88 15 32528 233 79711612
Drug hypersensitivity 59.11 13.88 24 32519 298892 79412953
Sinusitis 58.34 13.88 6 32537 195495 79516350
Arthropathy 56.77 13.88 4 32539 177107 79534738
Rash maculo-papular 56.19 13.88 90 32453 55988 79655857
Liver palpable 54.50 13.88 15 32528 346 79711499
Atrial fibrillation 53.50 13.88 190 32353 197696 79514149
Abdominal discomfort 53.15 13.88 18 32525 250709 79461136
Oedema peripheral 52.53 13.88 223 32320 252065 79459780
Hyperlactacidaemia 52.16 13.88 31 32512 5564 79706281
Alopecia 51.92 13.88 15 32528 231340 79480505
Medication error 51.57 13.88 97 32446 68545 79643300
Cerebral haematoma 51.54 13.88 35 32508 7907 79703938
Product monitoring error 50.20 13.88 36 32507 8870 79702975
Renal failure 50.14 13.88 188 32355 200780 79511065
Confusional state 50.01 13.88 259 32284 317738 79394107
Haematoma 49.89 13.88 82 32461 52113 79659732
Narrow anterior chamber angle 49.10 13.88 12 32531 170 79711675
Treatment failure 48.93 13.88 6 32537 170480 79541365
Hypoglycaemia 48.03 13.88 119 32424 101475 79610370
Electrocardiogram abnormal 46.69 13.88 45 32498 16692 79695153
Orthostatic hypotension 45.50 13.88 82 32461 56082 79655763
Presyncope 45.46 13.88 69 32474 40985 79670860
Swelling 45.16 13.88 16 32527 216695 79495150
Therapeutic product effect decreased 44.13 13.88 7 32536 163856 79547989
Inferior vena cava dilatation 41.50 13.88 15 32528 856 79710989
Toxic skin eruption 40.95 13.88 48 32495 22245 79689600
Rheumatoid arthritis 40.77 13.88 17 32526 208453 79503392
Ventricular enlargement 40.16 13.88 14 32529 718 79711127
Pancreatitis acute 39.64 13.88 72 32471 49532 79662313
Tachycardia 37.64 13.88 158 32385 177610 79534235
Transient aphasia 37.58 13.88 12 32531 468 79711377
Creutzfeldt-Jakob disease 37.45 13.88 10 32533 205 79711640
Drug intolerance 37.01 13.88 32 32511 264087 79447758
Renal artery stenosis 36.98 13.88 21 32522 3461 79708384
Cardiac failure 36.26 13.88 142 32401 154700 79557145
Renin increased 36.20 13.88 10 32533 234 79711611
Tongue oedema 36.11 13.88 27 32516 7090 79704755
Hypocalcaemia 35.58 13.88 69 32474 49855 79661990
Lens dislocation 35.40 13.88 9 32534 151 79711694
Atrial enlargement 35.33 13.88 14 32529 1029 79710816
Hypomagnesaemia 34.86 13.88 66 32477 46845 79665000
Supine hypertension 34.85 13.88 11 32532 413 79711432
Coma 34.69 13.88 105 32438 100544 79611301
Sopor 34.47 13.88 54 32489 32956 79678889
White blood cell count decreased 34.25 13.88 17 32526 188271 79523574
Vascular purpura 33.76 13.88 19 32524 3079 79708766
Therapeutic drug monitoring analysis not performed 32.93 13.88 16 32527 1920 79709925
Acute pulmonary oedema 31.91 13.88 34 32509 14196 79697649
Mobility decreased 31.18 13.88 6 32537 122169 79589676
Dyspnoea at rest 31.16 13.88 25 32518 7277 79704568
Arthralgia 31.13 13.88 124 32419 571679 79140166
Melaena 30.55 13.88 73 32470 60817 79651028
Asthma 29.85 13.88 9 32534 135086 79576759
Platelet count decreased 29.24 13.88 22 32521 194642 79517203
Meningorrhagia 29.04 13.88 9 32534 318 79711527
Interstitial lung disease 28.61 13.88 106 32437 112494 79599351
Therapeutic product effect incomplete 28.59 13.88 11 32532 141634 79570211
Helplessness 27.89 13.88 9 32534 363 79711482
Retinal artery occlusion 27.48 13.88 17 32526 3277 79708568
Peripheral ischaemia 27.47 13.88 26 32517 9431 79702414
Shock haemorrhagic 27.01 13.88 37 32506 20023 79691822
Altered state of consciousness 26.98 13.88 57 32486 43765 79668080
Hypovolaemic shock 26.94 13.88 29 32514 12247 79699598
Overdose 26.84 13.88 147 32396 184059 79527786
Pneumonia 26.77 13.88 159 32384 660087 79051758
Hypersensitivity 26.75 13.88 41 32502 262198 79449647
Mesenteric artery thrombosis 26.68 13.88 10 32533 632 79711213
Renal impairment 26.50 13.88 131 32412 157652 79554193
Injection site pain 26.34 13.88 10 32533 129828 79582017
Pulmonary vein occlusion 26.28 13.88 7 32536 142 79711703
Disease progression 26.23 13.88 22 32521 184340 79527505
Arrhythmia 26.07 13.88 69 32474 61203 79650642
Renal cyst 25.87 13.88 31 32512 14701 79697144
Hallucination, gustatory 25.78 13.88 6 32537 68 79711777
Cardiac failure congestive 25.68 13.88 13 32530 142389 79569456
Hallucination, visual 25.51 13.88 47 32496 32682 79679163
Epileptic encephalopathy 25.36 13.88 9 32534 487 79711358
Acute generalised exanthematous pustulosis 25.03 13.88 33 32510 17221 79694624
Coronary artery stenosis 24.82 13.88 28 32515 12456 79699389
Nephroangiosclerosis 24.37 13.88 8 32535 341 79711504
Cardiac failure chronic 23.90 13.88 26 32517 11109 79700736
Bundle branch block right 23.68 13.88 26 32517 11225 79700620
Cerebral haemorrhage 23.58 13.88 64 32479 57609 79654236
Haematemesis 23.41 13.88 60 32483 52204 79659641
Radiation fibrosis 23.40 13.88 5 32538 37 79711808
Neutrophil count decreased 23.18 13.88 5 32538 93954 79617891
Headache 23.16 13.88 164 32379 653608 79058237
Systemic infection 23.11 13.88 24 32519 9728 79702117
Migraine 22.97 13.88 4 32539 87489 79624356
Walking disability 22.96 13.88 13 32530 2130 79709715
Oropharyngeal pain 22.90 13.88 8 32535 109345 79602500
Hepatic cytolysis 22.44 13.88 40 32503 27111 79684734
Diabetic metabolic decompensation 22.37 13.88 15 32528 3317 79708528
Product use issue 22.18 13.88 32 32511 209790 79502055
Torsade de pointes 22.15 13.88 33 32510 19279 79692566
Spontaneous haematoma 21.95 13.88 11 32532 1411 79710434
Discomfort 21.86 13.88 12 32531 125605 79586240
Psoriatic arthropathy 21.76 13.88 3 32540 77996 79633849
Renal artery restenosis 21.68 13.88 4 32539 12 79711833
Laryngeal leukoplakia 21.54 13.88 5 32538 56 79711789
Lip oedema 21.54 13.88 19 32524 6297 79705548
Stomatitis 21.51 13.88 17 32526 146740 79565105
Immune-mediated pancreatitis 21.47 13.88 7 32536 292 79711553
Atrioventricular block complete 21.41 13.88 30 32513 16580 79695265
Duplicate therapy error 21.29 13.88 7 32536 300 79711545
Musculoskeletal stiffness 21.28 13.88 24 32519 174984 79536861
Rhinorrhoea 21.05 13.88 3 32540 76071 79635774
Suicide attempt 21 13.88 78 32465 82854 79628991
Haemorrhagic thyroid cyst 20.79 13.88 4 32539 16 79711829
Abdominal compartment syndrome 20.74 13.88 11 32532 1586 79710259
Mental status changes postoperative 20.33 13.88 6 32537 179 79711666
Inappropriate schedule of product administration 20.20 13.88 15 32528 133613 79578232
Weight increased 20.04 13.88 53 32490 277333 79434512
Arthritis 19.95 13.88 11 32532 114869 79596976
Acute coronary syndrome 19.92 13.88 33 32510 21100 79690745
Bundle branch block left 19.84 13.88 24 32519 11489 79700356
Oesophageal food impaction 19.56 13.88 7 32536 388 79711457
Hospitalisation 19.55 13.88 7 32536 94229 79617616
Joint swelling 19.48 13.88 57 32486 288589 79423256
Dyspnoea 19.47 13.88 472 32071 856553 78855292
Anti factor VIII antibody positive 19.39 13.88 5 32538 89 79711756
Depression 19.26 13.88 37 32506 216753 79495092
Confusion postoperative 19.25 13.88 6 32537 216 79711629
Hypertension 19.18 13.88 213 32330 330779 79381066
Loss of personal independence in daily activities 19.04 13.88 9 32534 102571 79609274
Accelerated hypertension 18.92 13.88 8 32535 694 79711151
Pseudophaeochromocytoma 18.79 13.88 5 32538 101 79711744
Angina pectoris 18.79 13.88 55 32488 51677 79660168
Blister 18.59 13.88 13 32530 119463 79592382
Mixed liver injury 18.59 13.88 19 32524 7559 79704286
Back pain 18.46 13.88 63 32480 304117 79407728
Intestinal villi atrophy 18.39 13.88 7 32536 462 79711383
Hepatic enzyme increased 18.18 13.88 29 32514 182581 79529264
Stress 18.14 13.88 5 32538 79607 79632238
Nocturia 18.07 13.88 25 32518 13656 79698189
Traumatic haematoma 18.05 13.88 11 32532 2065 79709780
Angioedema 18.00 13.88 70 32473 75965 79635880
Implant site inflammation 17.92 13.88 6 32537 272 79711573
Therapeutic response decreased 17.67 13.88 3 32540 66850 79644995
Oxygen saturation decreased 17.62 13.88 16 32527 129031 79582814
Wrong drug 17.55 13.88 6 32537 290 79711555
Necrotising myositis 17.22 13.88 9 32534 1259 79710586
Poisoning deliberate 17.21 13.88 29 32514 18799 79693046
Renal artery arteriosclerosis 16.90 13.88 4 32539 49 79711796
Hyperglycaemia 16.85 13.88 65 32478 70270 79641575
Respiratory alkalosis 16.80 13.88 14 32529 4297 79707548
Arterial spasm 16.64 13.88 5 32538 159 79711686
Convulsive threshold lowered 16.63 13.88 8 32535 939 79710906
Helicobacter infection 16.61 13.88 4 32539 69700 79642145
Frontotemporal dementia 16.55 13.88 7 32536 608 79711237
Amyotrophy 16.50 13.88 7 32536 613 79711232
Autoimmune enteropathy 16.48 13.88 4 32539 55 79711790
Bradyphrenia 16.45 13.88 21 32522 10619 79701226
Hemiplegia 16.38 13.88 25 32518 14914 79696931
Renal dysplasia 16.28 13.88 4 32539 58 79711787
Toxicity to various agents 16.27 13.88 103 32440 421437 79290408
Basal ganglia haematoma 16.15 13.88 4 32539 60 79711785
Atrioventricular block 16.11 13.88 24 32519 14017 79697828
Adenocarcinoma metastatic 15.88 13.88 5 32538 186 79711659
Vertigo 15.87 13.88 63 32480 69019 79642826
Retroperitoneal fibrosis 15.75 13.88 7 32536 686 79711159
Dermatitis exfoliative generalised 15.70 13.88 17 32526 7224 79704621
Injury 15.66 13.88 6 32537 77490 79634355
Tongue neoplasm malignant stage unspecified 15.60 13.88 8 32535 1076 79710769
Urethral cancer 15.58 13.88 4 32539 70 79711775
Therapeutic drug monitoring analysis incorrectly performed 15.53 13.88 7 32536 709 79711136
Agranulocytosis 15.53 13.88 47 32496 44983 79666862
Rhonchi 15.51 13.88 13 32530 4023 79707822
Rhabdomyolysis 15.48 13.88 83 32460 103048 79608797
Myopathy 15.36 13.88 29 32514 20534 79691311
Livedo reticularis 15.32 13.88 13 32530 4090 79707755
Adverse event 15.27 13.88 3 32540 60211 79651634
Dyspnoea exertional 15.11 13.88 73 32470 87000 79624845
Memory impairment 15.08 13.88 14 32529 111720 79600125
Claudication of jaw muscles 15.07 13.88 4 32539 80 79711765
Intermittent claudication 15.06 13.88 12 32531 3459 79708386
Hyperparathyroidism primary 14.94 13.88 6 32537 457 79711388
Delusional disorder, unspecified type 14.94 13.88 7 32536 775 79711070
Basal ganglia haemorrhage 14.90 13.88 9 32534 1662 79710183
Oesophageal achalasia 14.84 13.88 7 32536 787 79711058
Off label use 14.83 13.88 271 32272 906944 78804901
Glycosylated haemoglobin abnormal 14.80 13.88 5 32538 233 79711612
Xerosis 14.80 13.88 8 32535 1198 79710647
Gallbladder enlargement 14.80 13.88 9 32534 1684 79710161
Morbid thoughts 14.77 13.88 7 32536 795 79711050
Intracranial mass 14.76 13.88 10 32533 2249 79709596
Pneumocystis jirovecii infection 14.73 13.88 11 32532 2883 79708962
Infected lymphocele 14.68 13.88 5 32538 239 79711606
Hallucination, olfactory 14.63 13.88 6 32537 482 79711363
Body mass index abnormal 14.56 13.88 5 32538 245 79711600
Neuropathy peripheral 14.49 13.88 22 32521 141283 79570562
Crowned dens syndrome 14.44 13.88 3 32540 19 79711826
Orthostatic hypertension 14.42 13.88 7 32536 838 79711007
Haemolytic anaemia 14.40 13.88 26 32517 17794 79694051
Electrolyte imbalance 14.40 13.88 36 32507 30845 79681000
Prerenal failure 14.39 13.88 12 32531 3686 79708159
Feeling abnormal 14.28 13.88 27 32516 159172 79552673
Splenic rupture 14.11 13.88 10 32533 2419 79709426
Upper respiratory tract infection 14.08 13.88 10 32533 91158 79620687
Thyroid haemorrhage 14.08 13.88 4 32539 104 79711741
Obstructive pancreatitis 14.08 13.88 7 32536 883 79710962
Infection 14.03 13.88 51 32492 241661 79470184
Miosis 14.01 13.88 24 32519 15765 79696080
Traumatic haemothorax 13.90 13.88 6 32537 548 79711297

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA13 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C09BB02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09DB08 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.96 Basic
pKa2 2.09 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D01849 KEGG_DRUG
132866-11-6 SECONDARY_CAS_RN
C0526399 UMLSCUI
CHEBI:31771 CHEBI
CHEMBL250270 ChEMBL_ID
CHEMBL2106419 ChEMBL_ID
DB00528 DRUGBANK_ID
C060343 MESH_SUPPLEMENTAL_RECORD_UI
6971 INN_ID
V7XTJ4R0BH UNII
65866 PUBCHEM_CID
135056 RXNORM
007361 NDDF
007362 NDDF
356862006 SNOMEDCT_US
395768003 SNOMEDCT_US
395986007 SNOMEDCT_US

Pharmaceutical products:

None